2FI3I

Crystal structure of a bpti variant (cys14->ser, cys38->ser) in complex with trypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPSKARIIRYFYNAKAGLCQTFVYGGSRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Cationic trypsin
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2005-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2fi3I00
1TCPA 3BTKI 2W8XA 1MTND 1BPTA 1DTXA 3BYBA 1P2OB 1EJMB 3BTEI 7PTIA 5PTIA 1JV9A 2TGPI 3BTQI 3L33E 1BIKA 4NTWB 1T8OB 3AUGA 1BUNB 1TPAI 1T8NB 4NTXB 2KCRA 3TGKI 1SHPA 4WWYC 2CA7A 2UUYB 1P2II 2FI3I 3UOUB 1NAGA 4BD9B 1FY8I 4TPII 4Y0ZI 3BTDI 2ODYE 1AALA 1T7CB 3U1JE 3BTFI 3BTMI 2R9PE 1FAKI 3AUBA 1CBWD 4PTIA 3WNYA 3AUEA 3LDMA 1UUAA 4DG4C 2KAII 4DTGK 1JC6A 3LDIA 1QLQA 2UUXA 3M7QB 3T62D 1BZ5A 2M01A 3P95E 1BHCA 8PTIA 3P92E 5C67C 4NTYB 2TPII 1F5RI 2IJOI 1Y62A 1LD6A 1D0DB 3AUDA 3TGJI 1DTKA 1UUBA 3OFWA 4Y0YI 1YC0I 1LD5A 2ZJXA 1KTHA 3FP6I 2FTLI 3AUIA 1AAPA 1KIGI 3BTHI 1D0DA 5JB5A 1BF0A 1TOCR 1DENA 1OA55 1YLDB 3BTGI 2J6DA 1KNTA 2FI5I 3TPII 3CI7A 9PTIA 2FI4I 4U32X 3BTTI 4BQDA 1ZJDB 1TAPA 1BTIA 1P2JI 1BRBI 5JB4A 1P2MB 2JOTA 1G6XA 2LFKA 1JV8A 1EAWB 2DDIA 2DDJA 1B0CA 1F7ZI 4BNRI 6PTIA 1BRCI 1FANA 1YLCB 3GYMI 1ZR0B 1T8MB 3FP7J 5JB6A 1P2QB 3D65I 4Y10I 2PTCI 2LFLA 2RA3C 1CO7I 4ISOB 3FP8I 1DEMA 1YKTB 5JB7A 1BPIA 3L3TE 4ISNB 1K6UA 2KNTA 1P2KI 2HEXA 2M99A 3LDJA 2ZVXA 3TGII 3OTJI 1CA0D 2FTMB 1P2NB 1IRHA 1T8LB 3UIRC 4WXVC 1OA65 1TAWB 3AUHA 4ISLB 4Y11I 4U30W 1KUNA 3AUCA 1PITA 1ADZA 1TFXC 1BZXI 1BTHP 3BTWI
chains in the Genus database with same CATH superfamily
1TCPA 3BTKI 2W8XA 1MTND 1BPTA 1DTXA 3BYBA 1P2OB 1EJMB 3BTEI 7PTIA 5PTIA 1JV9A 2TGPI 3BTQI 3L33E 1BIKA 4NTWB 1T8OB 3AUGA 1BUNB 1TPAI 1T8NB 4NTXB 2KCRA 3TGKI 1SHPA 4WWYC 2CA7A 2UUYB 1P2II 2FI3I 3UOUB 1NAGA 4BD9B 1FY8I 4TPII 4Y0ZI 3BTDI 2ODYE 1AALA 1T7CB 3U1JE 3BTFI 3BTMI 2R9PE 1FAKI 3AUBA 1CBWD 4PTIA 3WNYA 3AUEA 3LDMA 1UUAA 4DG4C 2KAII 4DTGK 1JC6A 3LDIA 1QLQA 2UUXA 3M7QB 3T62D 1BZ5A 2M01A 3P95E 1BHCA 8PTIA 3P92E 5C67C 4NTYB 2TPII 1F5RI 2IJOI 1Y62A 1LD6A 1D0DB 3AUDA 3TGJI 1DTKA 1UUBA 3OFWA 4Y0YI 1YC0I 1LD5A 2ZJXA 1KTHA 3FP6I 2FTLI 3AUIA 1AAPA 1KIGI 3BTHI 1D0DA 5JB5A 1BF0A 1TOCR 1DENA 1OA55 1YLDB 3BTGI 2J6DA 1KNTA 2FI5I 3TPII 3CI7A 9PTIA 2FI4I 4U32X 3BTTI 4BQDA 1ZJDB 1TAPA 1BTIA 1P2JI 1BRBI 5JB4A 1P2MB 2JOTA 1G6XA 2LFKA 1JV8A 1EAWB 2DDIA 2DDJA 1B0CA 1F7ZI 4BNRI 6PTIA 1BRCI 1FANA 1YLCB 3GYMI 1ZR0B 1T8MB 3FP7J 5JB6A 1P2QB 3D65I 4Y10I 2PTCI 2LFLA 2RA3C 1CO7I 4ISOB 3FP8I 1DEMA 1YKTB 5JB7A 1BPIA 3L3TE 4ISNB 1K6UA 2KNTA 1P2KI 2HEXA 2M99A 3LDJA 2ZVXA 3TGII 3OTJI 1CA0D 2FTMB 1P2NB 1IRHA 1T8LB 3UIRC 4WXVC 1OA65 1TAWB 3AUHA 4ISLB 4Y11I 4U30W 1KUNA 3AUCA 1PITA 1ADZA 1TFXC 1BZXI 1BTHP 3BTWI
chains in the Genus database with same CATH topology
1TCPA 3BTKI 2W8XA 1MTND 1BPTA 1DTXA 3BYBA 1P2OB 1EJMB 3BTEI 7PTIA 5PTIA 1JV9A 2TGPI 3BTQI 3L33E 1BIKA 4NTWB 1T8OB 3AUGA 1BUNB 1TPAI 1T8NB 4NTXB 2KCRA 3TGKI 1SHPA 4WWYC 2CA7A 2UUYB 1P2II 2FI3I 3UOUB 1NAGA 4BD9B 1FY8I 4TPII 4Y0ZI 3BTDI 2ODYE 1AALA 1T7CB 3U1JE 3BTFI 3BTMI 2R9PE 1FAKI 3AUBA 1CBWD 4PTIA 3WNYA 3AUEA 3LDMA 1UUAA 4DG4C 2KAII 4DTGK 1JC6A 3LDIA 1QLQA 2UUXA 3M7QB 3T62D 1BZ5A 2M01A 3P95E 1BHCA 8PTIA 3P92E 5C67C 4NTYB 2TPII 1F5RI 2IJOI 1Y62A 1LD6A 1D0DB 3AUDA 3TGJI 1DTKA 1UUBA 3OFWA 4Y0YI 1YC0I 1LD5A 2ZJXA 1KTHA 3FP6I 2FTLI 3AUIA 1AAPA 1KIGI 3BTHI 1D0DA 5JB5A 1BF0A 1TOCR 1DENA 1OA55 1YLDB 3BTGI 2J6DA 1KNTA 2FI5I 3TPII 3CI7A 9PTIA 2FI4I 4U32X 3BTTI 4BQDA 1ZJDB 1TAPA 1BTIA 1P2JI 1BRBI 5JB4A 1P2MB 2JOTA 1G6XA 2LFKA 1JV8A 1EAWB 2DDIA 2DDJA 1B0CA 1F7ZI 4BNRI 6PTIA 1BRCI 1FANA 1YLCB 3GYMI 1ZR0B 1T8MB 3FP7J 5JB6A 1P2QB 3D65I 4Y10I 2PTCI 2LFLA 2RA3C 1CO7I 4ISOB 3FP8I 1DEMA 1YKTB 5JB7A 1BPIA 3L3TE 4ISNB 1K6UA 2KNTA 1P2KI 2HEXA 2M99A 3LDJA 2ZVXA 3TGII 3OTJI 1CA0D 2FTMB 1P2NB 1IRHA 1T8LB 3UIRC 4WXVC 1OA65 1TAWB 3AUHA 4ISLB 4Y11I 4U30W 1KUNA 3AUCA 1PITA 1ADZA 1TFXC 1BZXI 1BTHP 3BTWI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TCP A;  3BTK I;  2W8X A;  1MTN D;  1BPT A;  1DTX A;  3BYB A;  1P2O B;  1EJM B;  3BTE I;  7PTI A;  5PTI A;  1JV9 A;  2TGP I;  3BTQ I;  3L33 E;  1BIK A;  4NTW B;  1T8O B;  3AUG A;  1BUN B;  1TPA I;  1T8N B;  4NTX B;  2KCR A;  3TGK I;  1SHP A;  4WWY C;  2CA7 A;  2UUY B;  1P2I I;  2FI3 I;  3UOU B;  1NAG A;  4BD9 B;  1FY8 I;  4TPI I;  4Y0Z I;  3BTD I;  2ODY E;  1AAL A;  1T7C B;  3U1J E;  3BTF I;  3BTM I;  2R9P E;  1FAK I;  3AUB A;  1CBW D;  4PTI A;  3WNY A;  3AUE A;  3LDM A;  1UUA A;  4DG4 C;  2KAI I;  4DTG K;  1JC6 A;  3LDI A;  1QLQ A;  2UUX A;  3M7Q B;  3T62 D;  1BZ5 A;  2M01 A;  3P95 E;  1BHC A;  8PTI A;  3P92 E;  5C67 C;  4NTY B;  2TPI I;  1F5R I;  2IJO I;  1Y62 A;  1LD6 A;  1D0D B;  3AUD A;  3TGJ I;  1DTK A;  1UUB A;  3OFW A;  4Y0Y I;  1YC0 I;  1LD5 A;  2ZJX A;  1KTH A;  3FP6 I;  2FTL I;  3AUI A;  1AAP A;  1KIG I;  3BTH I;  1D0D A;  5JB5 A;  1BF0 A;  1TOC R;  1DEN A;  1OA5 5;  1YLD B;  3BTG I;  2J6D A;  1KNT A;  2FI5 I;  3TPI I;  3CI7 A;  9PTI A;  2FI4 I;  4U32 X;  3BTT I;  4BQD A;  1ZJD B;  1TAP A;  1BTI A;  1P2J I;  1BRB I;  5JB4 A;  1P2M B;  2JOT A;  1G6X A;  2LFK A;  1JV8 A;  1EAW B;  2DDI A;  2DDJ A;  1B0C A;  1F7Z I;  4BNR I;  6PTI A;  1BRC I;  1FAN A;  1YLC B;  3GYM I;  1ZR0 B;  1T8M B;  3FP7 J;  5JB6 A;  1P2Q B;  3D65 I;  4Y10 I;  2PTC I;  2LFL A;  2RA3 C;  1CO7 I;  4ISO B;  3FP8 I;  1DEM A;  1YKT B;  5JB7 A;  1BPI A;  3L3T E;  4ISN B;  1K6U A;  2KNT A;  1P2K I;  2HEX A;  2M99 A;  3LDJ A;  2ZVX A;  3TGI I;  3OTJ I;  1CA0 D;  2FTM B;  1P2N B;  1IRH A;  1T8L B;  3UIR C;  4WXV C;  1OA6 5;  1TAW B;  3AUH A;  4ISL B;  4Y11 I;  4U30 W;  1KUN A;  3AUC A;  1PIT A;  1ADZ A;  1TFX C;  1BZX I;  1BTH P;  3BTW I; 
#chains in the Genus database with same CATH topology
 1TCP A;  3BTK I;  2W8X A;  1MTN D;  1BPT A;  1DTX A;  3BYB A;  1P2O B;  1EJM B;  3BTE I;  7PTI A;  5PTI A;  1JV9 A;  2TGP I;  3BTQ I;  3L33 E;  1BIK A;  4NTW B;  1T8O B;  3AUG A;  1BUN B;  1TPA I;  1T8N B;  4NTX B;  2KCR A;  3TGK I;  1SHP A;  4WWY C;  2CA7 A;  2UUY B;  1P2I I;  2FI3 I;  3UOU B;  1NAG A;  4BD9 B;  1FY8 I;  4TPI I;  4Y0Z I;  3BTD I;  2ODY E;  1AAL A;  1T7C B;  3U1J E;  3BTF I;  3BTM I;  2R9P E;  1FAK I;  3AUB A;  1CBW D;  4PTI A;  3WNY A;  3AUE A;  3LDM A;  1UUA A;  4DG4 C;  2KAI I;  4DTG K;  1JC6 A;  3LDI A;  1QLQ A;  2UUX A;  3M7Q B;  3T62 D;  1BZ5 A;  2M01 A;  3P95 E;  1BHC A;  8PTI A;  3P92 E;  5C67 C;  4NTY B;  2TPI I;  1F5R I;  2IJO I;  1Y62 A;  1LD6 A;  1D0D B;  3AUD A;  3TGJ I;  1DTK A;  1UUB A;  3OFW A;  4Y0Y I;  1YC0 I;  1LD5 A;  2ZJX A;  1KTH A;  3FP6 I;  2FTL I;  3AUI A;  1AAP A;  1KIG I;  3BTH I;  1D0D A;  5JB5 A;  1BF0 A;  1TOC R;  1DEN A;  1OA5 5;  1YLD B;  3BTG I;  2J6D A;  1KNT A;  2FI5 I;  3TPI I;  3CI7 A;  9PTI A;  2FI4 I;  4U32 X;  3BTT I;  4BQD A;  1ZJD B;  1TAP A;  1BTI A;  1P2J I;  1BRB I;  5JB4 A;  1P2M B;  2JOT A;  1G6X A;  2LFK A;  1JV8 A;  1EAW B;  2DDI A;  2DDJ A;  1B0C A;  1F7Z I;  4BNR I;  6PTI A;  1BRC I;  1FAN A;  1YLC B;  3GYM I;  1ZR0 B;  1T8M B;  3FP7 J;  5JB6 A;  1P2Q B;  3D65 I;  4Y10 I;  2PTC I;  2LFL A;  2RA3 C;  1CO7 I;  4ISO B;  3FP8 I;  1DEM A;  1YKT B;  5JB7 A;  1BPI A;  3L3T E;  4ISN B;  1K6U A;  2KNT A;  1P2K I;  2HEX A;  2M99 A;  3LDJ A;  2ZVX A;  3TGI I;  3OTJ I;  1CA0 D;  2FTM B;  1P2N B;  1IRH A;  1T8L B;  3UIR C;  4WXV C;  1OA6 5;  1TAW B;  3AUH A;  4ISL B;  4Y11 I;  4U30 W;  1KUN A;  3AUC A;  1PIT A;  1ADZ A;  1TFX C;  1BZX I;  1BTH P;  3BTW I; 
#chains in the Genus database with same CATH homology
 1TCP A;  3BTK I;  2W8X A;  1MTN D;  1BPT A;  1DTX A;  3BYB A;  1P2O B;  1EJM B;  3BTE I;  7PTI A;  5PTI A;  1JV9 A;  2TGP I;  3BTQ I;  3L33 E;  1BIK A;  4NTW B;  1T8O B;  3AUG A;  1BUN B;  1TPA I;  1T8N B;  4NTX B;  2KCR A;  3TGK I;  1SHP A;  4WWY C;  2CA7 A;  2UUY B;  1P2I I;  2FI3 I;  3UOU B;  1NAG A;  4BD9 B;  1FY8 I;  4TPI I;  4Y0Z I;  3BTD I;  2ODY E;  1AAL A;  1T7C B;  3U1J E;  3BTF I;  3BTM I;  2R9P E;  1FAK I;  3AUB A;  1CBW D;  4PTI A;  3WNY A;  3AUE A;  3LDM A;  1UUA A;  4DG4 C;  2KAI I;  4DTG K;  1JC6 A;  3LDI A;  1QLQ A;  2UUX A;  3M7Q B;  3T62 D;  1BZ5 A;  2M01 A;  3P95 E;  1BHC A;  8PTI A;  3P92 E;  5C67 C;  4NTY B;  2TPI I;  1F5R I;  2IJO I;  1Y62 A;  1LD6 A;  1D0D B;  3AUD A;  3TGJ I;  1DTK A;  1UUB A;  3OFW A;  4Y0Y I;  1YC0 I;  1LD5 A;  2ZJX A;  1KTH A;  3FP6 I;  2FTL I;  3AUI A;  1AAP A;  1KIG I;  3BTH I;  1D0D A;  5JB5 A;  1BF0 A;  1TOC R;  1DEN A;  1OA5 5;  1YLD B;  3BTG I;  2J6D A;  1KNT A;  2FI5 I;  3TPI I;  3CI7 A;  9PTI A;  2FI4 I;  4U32 X;  3BTT I;  4BQD A;  1ZJD B;  1TAP A;  1BTI A;  1P2J I;  1BRB I;  5JB4 A;  1P2M B;  2JOT A;  1G6X A;  2LFK A;  1JV8 A;  1EAW B;  2DDI A;  2DDJ A;  1B0C A;  1F7Z I;  4BNR I;  6PTI A;  1BRC I;  1FAN A;  1YLC B;  3GYM I;  1ZR0 B;  1T8M B;  3FP7 J;  5JB6 A;  1P2Q B;  3D65 I;  4Y10 I;  2PTC I;  2LFL A;  2RA3 C;  1CO7 I;  4ISO B;  3FP8 I;  1DEM A;  1YKT B;  5JB7 A;  1BPI A;  3L3T E;  4ISN B;  1K6U A;  2KNT A;  1P2K I;  2HEX A;  2M99 A;  3LDJ A;  2ZVX A;  3TGI I;  3OTJ I;  1CA0 D;  2FTM B;  1P2N B;  1IRH A;  1T8L B;  3UIR C;  4WXV C;  1OA6 5;  1TAW B;  3AUH A;  4ISL B;  4Y11 I;  4U30 W;  1KUN A;  3AUC A;  1PIT A;  1ADZ A;  1TFX C;  1BZX I;  1BTH P;  3BTW I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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