2FI5I

Crystal structure of a bpti variant (cys38->ser) in complex with trypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGSRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Cationic trypsin
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2005-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2fi5I00
3BYBA 2ZJXA 1BPIA 3TGKI 1F5RI 1BUNB 1JC6A 1NAGA 3BTDI 3BTHI 3L33E 3L3TE 1IRHA 2HEXA 1DTKA 1TAWB 3GYMI 1OA65 1TFXC 1YC0I 4Y0ZI 1T8OB 4NTXB 4U30W 2KCRA 1P2NB 1ZR0B 1FY8I 7PTIA 3BTWI 3CI7A 2J6DA 5C67C 1KUNA 2JOTA 3P95E 3UOUB 1P2MB 3D65I 2TGPI 1T7CB 4ISLB 1BHCA 1BRCI 3T62D 1PITA 4BQDA 3AUCA 1P2OB 2LFLA 2ODYE 2R9PE 3AUEA 3AUBA 1Y62A 1P2JI 3U1JE 1D0DB 1BPTA 4BNRI 1BZ5A 1YLDB 1KIGI 6PTIA 1SHPA 1B0CA 1P2KI 3BTGI 1P2II 3FP8I 3BTTI 4WWYC 2RA3C 3WNYA 1JV8A 4ISNB 3TGII 2CA7A 2FI4I 1OA55 2PTCI 3BTEI 1AAPA 1QLQA 1TCPA 2LFKA 3AUDA 2KAII 1MTND 3UIRC 1EAWB 1UUBA 1FAKI 1YKTB 5JB6A 1EJMB 1P2QB 1ZJDB 1BF0A 1BRBI 3BTQI 1KTHA 3BTKI 3AUGA 3OFWA 4BD9B 1TPAI 1BIKA 1BTHP 1BTIA 3P92E 4Y10I 1CO7I 4DTGK 3FP7J 2FTMB 2ZVXA 2FTLI 3LDIA 2IJOI 9PTIA 1DENA 3LDMA 4PTIA 1AALA 4TPII 2KNTA 1T8NB 1CBWD 2DDJA 4ISOB 2FI3I 1YLCB 1UUAA 1KNTA 8PTIA 5PTIA 1JV9A 3M7QB 1CA0D 4NTWB 5JB4A 1K6UA 1FANA 2W8XA 1T8MB 1BZXI 1DTXA 3AUIA 2FI5I 5JB5A 1TOCR 3TPII 2TPII 1D0DA 1LD6A 3OTJI 4Y0YI 5JB7A 1DEMA 4WXVC 4Y11I 2M99A 4U32X 4NTYB 1T8LB 2UUYB 3FP6I 2UUXA 1ADZA 1F7ZI 2M01A 3BTMI 3LDJA 3BTFI 2DDIA 1TAPA 3TGJI 1LD5A 4DG4C 1G6XA 3AUHA
chains in the Genus database with same CATH superfamily
3BYBA 2ZJXA 1BPIA 3TGKI 1F5RI 1BUNB 1JC6A 1NAGA 3BTDI 3BTHI 3L33E 3L3TE 1IRHA 2HEXA 1DTKA 1TAWB 3GYMI 1OA65 1TFXC 1YC0I 4Y0ZI 1T8OB 4NTXB 4U30W 2KCRA 1P2NB 1ZR0B 1FY8I 7PTIA 3BTWI 3CI7A 2J6DA 5C67C 1KUNA 2JOTA 3P95E 3UOUB 1P2MB 3D65I 2TGPI 1T7CB 4ISLB 1BHCA 1BRCI 3T62D 1PITA 4BQDA 3AUCA 1P2OB 2LFLA 2ODYE 2R9PE 3AUEA 3AUBA 1Y62A 1P2JI 3U1JE 1D0DB 1BPTA 4BNRI 1BZ5A 1YLDB 1KIGI 6PTIA 1SHPA 1B0CA 1P2KI 3BTGI 1P2II 3FP8I 3BTTI 4WWYC 2RA3C 3WNYA 1JV8A 4ISNB 3TGII 2CA7A 2FI4I 1OA55 2PTCI 3BTEI 1AAPA 1QLQA 1TCPA 2LFKA 3AUDA 2KAII 1MTND 3UIRC 1EAWB 1UUBA 1FAKI 1YKTB 5JB6A 1EJMB 1P2QB 1ZJDB 1BF0A 1BRBI 3BTQI 1KTHA 3BTKI 3AUGA 3OFWA 4BD9B 1TPAI 1BIKA 1BTHP 1BTIA 3P92E 4Y10I 1CO7I 4DTGK 3FP7J 2FTMB 2ZVXA 2FTLI 3LDIA 2IJOI 9PTIA 1DENA 3LDMA 4PTIA 1AALA 4TPII 2KNTA 1T8NB 1CBWD 2DDJA 4ISOB 2FI3I 1YLCB 1UUAA 1KNTA 8PTIA 5PTIA 1JV9A 3M7QB 1CA0D 4NTWB 5JB4A 1K6UA 1FANA 2W8XA 1T8MB 1BZXI 1DTXA 3AUIA 2FI5I 5JB5A 1TOCR 3TPII 2TPII 1D0DA 1LD6A 3OTJI 4Y0YI 5JB7A 1DEMA 4WXVC 4Y11I 2M99A 4U32X 4NTYB 1T8LB 2UUYB 3FP6I 2UUXA 1ADZA 1F7ZI 2M01A 3BTMI 3LDJA 3BTFI 2DDIA 1TAPA 3TGJI 1LD5A 4DG4C 1G6XA 3AUHA
chains in the Genus database with same CATH topology
3BYBA 2ZJXA 1BPIA 3TGKI 1F5RI 1BUNB 1JC6A 1NAGA 3BTDI 3BTHI 3L33E 3L3TE 1IRHA 2HEXA 1DTKA 1TAWB 3GYMI 1OA65 1TFXC 1YC0I 4Y0ZI 1T8OB 4NTXB 4U30W 2KCRA 1P2NB 1ZR0B 1FY8I 7PTIA 3BTWI 3CI7A 2J6DA 5C67C 1KUNA 2JOTA 3P95E 3UOUB 1P2MB 3D65I 2TGPI 1T7CB 4ISLB 1BHCA 1BRCI 3T62D 1PITA 4BQDA 3AUCA 1P2OB 2LFLA 2ODYE 2R9PE 3AUEA 3AUBA 1Y62A 1P2JI 3U1JE 1D0DB 1BPTA 4BNRI 1BZ5A 1YLDB 1KIGI 6PTIA 1SHPA 1B0CA 1P2KI 3BTGI 1P2II 3FP8I 3BTTI 4WWYC 2RA3C 3WNYA 1JV8A 4ISNB 3TGII 2CA7A 2FI4I 1OA55 2PTCI 3BTEI 1AAPA 1QLQA 1TCPA 2LFKA 3AUDA 2KAII 1MTND 3UIRC 1EAWB 1UUBA 1FAKI 1YKTB 5JB6A 1EJMB 1P2QB 1ZJDB 1BF0A 1BRBI 3BTQI 1KTHA 3BTKI 3AUGA 3OFWA 4BD9B 1TPAI 1BIKA 1BTHP 1BTIA 3P92E 4Y10I 1CO7I 4DTGK 3FP7J 2FTMB 2ZVXA 2FTLI 3LDIA 2IJOI 9PTIA 1DENA 3LDMA 4PTIA 1AALA 4TPII 2KNTA 1T8NB 1CBWD 2DDJA 4ISOB 2FI3I 1YLCB 1UUAA 1KNTA 8PTIA 5PTIA 1JV9A 3M7QB 1CA0D 4NTWB 5JB4A 1K6UA 1FANA 2W8XA 1T8MB 1BZXI 1DTXA 3AUIA 2FI5I 5JB5A 1TOCR 3TPII 2TPII 1D0DA 1LD6A 3OTJI 4Y0YI 5JB7A 1DEMA 4WXVC 4Y11I 2M99A 4U32X 4NTYB 1T8LB 2UUYB 3FP6I 2UUXA 1ADZA 1F7ZI 2M01A 3BTMI 3LDJA 3BTFI 2DDIA 1TAPA 3TGJI 1LD5A 4DG4C 1G6XA 3AUHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BYB A;  2ZJX A;  1BPI A;  3TGK I;  1F5R I;  1BUN B;  1JC6 A;  1NAG A;  3BTD I;  3BTH I;  3L33 E;  3L3T E;  1IRH A;  2HEX A;  1DTK A;  1TAW B;  3GYM I;  1OA6 5;  1TFX C;  1YC0 I;  4Y0Z I;  1T8O B;  4NTX B;  4U30 W;  2KCR A;  1P2N B;  1ZR0 B;  1FY8 I;  7PTI A;  3BTW I;  3CI7 A;  2J6D A;  5C67 C;  1KUN A;  2JOT A;  3P95 E;  3UOU B;  1P2M B;  3D65 I;  2TGP I;  1T7C B;  4ISL B;  1BHC A;  1BRC I;  3T62 D;  1PIT A;  4BQD A;  3AUC A;  1P2O B;  2LFL A;  2ODY E;  2R9P E;  3AUE A;  3AUB A;  1Y62 A;  1P2J I;  3U1J E;  1D0D B;  1BPT A;  4BNR I;  1BZ5 A;  1YLD B;  1KIG I;  6PTI A;  1SHP A;  1B0C A;  1P2K I;  3BTG I;  1P2I I;  3FP8 I;  3BTT I;  4WWY C;  2RA3 C;  3WNY A;  1JV8 A;  4ISN B;  3TGI I;  2CA7 A;  2FI4 I;  1OA5 5;  2PTC I;  3BTE I;  1AAP A;  1QLQ A;  1TCP A;  2LFK A;  3AUD A;  2KAI I;  1MTN D;  3UIR C;  1EAW B;  1UUB A;  1FAK I;  1YKT B;  5JB6 A;  1EJM B;  1P2Q B;  1ZJD B;  1BF0 A;  1BRB I;  3BTQ I;  1KTH A;  3BTK I;  3AUG A;  3OFW A;  4BD9 B;  1TPA I;  1BIK A;  1BTH P;  1BTI A;  3P92 E;  4Y10 I;  1CO7 I;  4DTG K;  3FP7 J;  2FTM B;  2ZVX A;  2FTL I;  3LDI A;  2IJO I;  9PTI A;  1DEN A;  3LDM A;  4PTI A;  1AAL A;  4TPI I;  2KNT A;  1T8N B;  1CBW D;  2DDJ A;  4ISO B;  2FI3 I;  1YLC B;  1UUA A;  1KNT A;  8PTI A;  5PTI A;  1JV9 A;  3M7Q B;  1CA0 D;  4NTW B;  5JB4 A;  1K6U A;  1FAN A;  2W8X A;  1T8M B;  1BZX I;  1DTX A;  3AUI A;  2FI5 I;  5JB5 A;  1TOC R;  3TPI I;  2TPI I;  1D0D A;  1LD6 A;  3OTJ I;  4Y0Y I;  5JB7 A;  1DEM A;  4WXV C;  4Y11 I;  2M99 A;  4U32 X;  4NTY B;  1T8L B;  2UUY B;  3FP6 I;  2UUX A;  1ADZ A;  1F7Z I;  2M01 A;  3BTM I;  3LDJ A;  3BTF I;  2DDI A;  1TAP A;  3TGJ I;  1LD5 A;  4DG4 C;  1G6X A;  3AUH A; 
#chains in the Genus database with same CATH topology
 3BYB A;  2ZJX A;  1BPI A;  3TGK I;  1F5R I;  1BUN B;  1JC6 A;  1NAG A;  3BTD I;  3BTH I;  3L33 E;  3L3T E;  1IRH A;  2HEX A;  1DTK A;  1TAW B;  3GYM I;  1OA6 5;  1TFX C;  1YC0 I;  4Y0Z I;  1T8O B;  4NTX B;  4U30 W;  2KCR A;  1P2N B;  1ZR0 B;  1FY8 I;  7PTI A;  3BTW I;  3CI7 A;  2J6D A;  5C67 C;  1KUN A;  2JOT A;  3P95 E;  3UOU B;  1P2M B;  3D65 I;  2TGP I;  1T7C B;  4ISL B;  1BHC A;  1BRC I;  3T62 D;  1PIT A;  4BQD A;  3AUC A;  1P2O B;  2LFL A;  2ODY E;  2R9P E;  3AUE A;  3AUB A;  1Y62 A;  1P2J I;  3U1J E;  1D0D B;  1BPT A;  4BNR I;  1BZ5 A;  1YLD B;  1KIG I;  6PTI A;  1SHP A;  1B0C A;  1P2K I;  3BTG I;  1P2I I;  3FP8 I;  3BTT I;  4WWY C;  2RA3 C;  3WNY A;  1JV8 A;  4ISN B;  3TGI I;  2CA7 A;  2FI4 I;  1OA5 5;  2PTC I;  3BTE I;  1AAP A;  1QLQ A;  1TCP A;  2LFK A;  3AUD A;  2KAI I;  1MTN D;  3UIR C;  1EAW B;  1UUB A;  1FAK I;  1YKT B;  5JB6 A;  1EJM B;  1P2Q B;  1ZJD B;  1BF0 A;  1BRB I;  3BTQ I;  1KTH A;  3BTK I;  3AUG A;  3OFW A;  4BD9 B;  1TPA I;  1BIK A;  1BTH P;  1BTI A;  3P92 E;  4Y10 I;  1CO7 I;  4DTG K;  3FP7 J;  2FTM B;  2ZVX A;  2FTL I;  3LDI A;  2IJO I;  9PTI A;  1DEN A;  3LDM A;  4PTI A;  1AAL A;  4TPI I;  2KNT A;  1T8N B;  1CBW D;  2DDJ A;  4ISO B;  2FI3 I;  1YLC B;  1UUA A;  1KNT A;  8PTI A;  5PTI A;  1JV9 A;  3M7Q B;  1CA0 D;  4NTW B;  5JB4 A;  1K6U A;  1FAN A;  2W8X A;  1T8M B;  1BZX I;  1DTX A;  3AUI A;  2FI5 I;  5JB5 A;  1TOC R;  3TPI I;  2TPI I;  1D0D A;  1LD6 A;  3OTJ I;  4Y0Y I;  5JB7 A;  1DEM A;  4WXV C;  4Y11 I;  2M99 A;  4U32 X;  4NTY B;  1T8L B;  2UUY B;  3FP6 I;  2UUX A;  1ADZ A;  1F7Z I;  2M01 A;  3BTM I;  3LDJ A;  3BTF I;  2DDI A;  1TAP A;  3TGJ I;  1LD5 A;  4DG4 C;  1G6X A;  3AUH A; 
#chains in the Genus database with same CATH homology
 3BYB A;  2ZJX A;  1BPI A;  3TGK I;  1F5R I;  1BUN B;  1JC6 A;  1NAG A;  3BTD I;  3BTH I;  3L33 E;  3L3T E;  1IRH A;  2HEX A;  1DTK A;  1TAW B;  3GYM I;  1OA6 5;  1TFX C;  1YC0 I;  4Y0Z I;  1T8O B;  4NTX B;  4U30 W;  2KCR A;  1P2N B;  1ZR0 B;  1FY8 I;  7PTI A;  3BTW I;  3CI7 A;  2J6D A;  5C67 C;  1KUN A;  2JOT A;  3P95 E;  3UOU B;  1P2M B;  3D65 I;  2TGP I;  1T7C B;  4ISL B;  1BHC A;  1BRC I;  3T62 D;  1PIT A;  4BQD A;  3AUC A;  1P2O B;  2LFL A;  2ODY E;  2R9P E;  3AUE A;  3AUB A;  1Y62 A;  1P2J I;  3U1J E;  1D0D B;  1BPT A;  4BNR I;  1BZ5 A;  1YLD B;  1KIG I;  6PTI A;  1SHP A;  1B0C A;  1P2K I;  3BTG I;  1P2I I;  3FP8 I;  3BTT I;  4WWY C;  2RA3 C;  3WNY A;  1JV8 A;  4ISN B;  3TGI I;  2CA7 A;  2FI4 I;  1OA5 5;  2PTC I;  3BTE I;  1AAP A;  1QLQ A;  1TCP A;  2LFK A;  3AUD A;  2KAI I;  1MTN D;  3UIR C;  1EAW B;  1UUB A;  1FAK I;  1YKT B;  5JB6 A;  1EJM B;  1P2Q B;  1ZJD B;  1BF0 A;  1BRB I;  3BTQ I;  1KTH A;  3BTK I;  3AUG A;  3OFW A;  4BD9 B;  1TPA I;  1BIK A;  1BTH P;  1BTI A;  3P92 E;  4Y10 I;  1CO7 I;  4DTG K;  3FP7 J;  2FTM B;  2ZVX A;  2FTL I;  3LDI A;  2IJO I;  9PTI A;  1DEN A;  3LDM A;  4PTI A;  1AAL A;  4TPI I;  2KNT A;  1T8N B;  1CBW D;  2DDJ A;  4ISO B;  2FI3 I;  1YLC B;  1UUA A;  1KNT A;  8PTI A;  5PTI A;  1JV9 A;  3M7Q B;  1CA0 D;  4NTW B;  5JB4 A;  1K6U A;  1FAN A;  2W8X A;  1T8M B;  1BZX I;  1DTX A;  3AUI A;  2FI5 I;  5JB5 A;  1TOC R;  3TPI I;  2TPI I;  1D0D A;  1LD6 A;  3OTJ I;  4Y0Y I;  5JB7 A;  1DEM A;  4WXV C;  4Y11 I;  2M99 A;  4U32 X;  4NTY B;  1T8L B;  2UUY B;  3FP6 I;  2UUX A;  1ADZ A;  1F7Z I;  2M01 A;  3BTM I;  3LDJ A;  3BTF I;  2DDI A;  1TAP A;  3TGJ I;  1LD5 A;  4DG4 C;  1G6X A;  3AUH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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