2GG5A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 81
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg5A00
4FLKA 2BB7A 1YVMA 4IECA 1N51A 1XGNA 4ZWOA 2BWXA 4U1BA 1O0XA 2EVOA 4KM3A 2GU6A 4FLJA 3S6BA 1XGOA 4U76A 4U6ZA 2GGCA 1C24A 1R58A 1WN1A 3L7GA 1W2MA 2G6PA 2GGBA 3Q6DA 4Z7MA 5D6EA 5CDVA 2V6CA 4ZNGA 1QXYA 2OAZA 2NQ6A 5FCFA 1WL9A 2B3HA 1KP0A 3BIQA 1MATA 2B3LA 3L24A 4FLLA 1YW9A 3IG4A 1C21A 4RZZA 1XNZA 5CE6A 4PV4A 4B28A 3PKCA 4IDYA 3BIPA 2DFIA 5E5BA 5FCHA 1CHMA 4U70A 2BHDA 2BHBA 3MR1A 2GTXA 3IU7A 1QXZA 2GG5A 3IU8A 5CDEA 2BWVA 4U69A 4A6VA 2BH3A 2BWWA 3MX6A 4IKUA 4PNCA 1BOAA 1XGSA 2GG0A 1R5GA 4A6WA 4JUQA 1WKMA 4U71A 1A16A 1Y1NA 2BWUA 4U75A 1B59A 2P98A 1C27A 2GG2A 1WLRA 3CB5A 2EA4A 2Q96A 1M35A 1PV9A 2GG7A 3TB5A 5CLSA 1YW8A 2BWSA 2GG3A 3CTZA 1C22A 3FM3A 2BN7A 3MATA 2GG9A 4RGZ1 1W7VA 4S01A 5CDLA 2GA2A 3RORA 4EGEA 2IW2A 3PKAA 3BITA 1R5HA 2B3KA 1WL6A 4S2RP 4QR8A 4FLIA 3RVAA 2Q93A 2BWTA 1KQ9A 4U6EA 2HOWA 2NQ7A 4IPAA 2GU7A 5CIKA 2P9AA 1BN5A 3TAVA 4IKSA 2BWYA 2BHAA 3PKEA 2Q95A 4FUKA 1WY2A 2ADUA 4OOKA 1YJ3A 4U6WA 4U6CA 4FO7A 4ZWPA 3IU9A 2Q8KA 1QXWA 2MATA 4IF7A 4IU6A 3D27A 2V3YA 4MATA 1JAWA 1QZYA 2Q92A 1C23A 5CNXA 1KQ0A 4FO8A 5JI6A 3FMRA 4HXXA 2BHCA 4U73A 1YW7A 2EVCA 2OKNA 2GZ5A 1B6AA 4ZWUA 1WBQA 4S2TP 3CB6A 3PKBA 4FKCA 2GU4A 4U6JA 1XGMA 2Q94A 5D6FA 2V3ZA 4IKTA 4S00A 2GG8A 2GU5A 2EVMA 5JHUA 4RZYA 4IKRA 2EA2A 5JFRA 3PKDA 4R60A 3FMQA 2V3XA 2P99A 2ZSGA
chains in the Genus database with same CATH superfamily
4FLKA 2BB7A 1YVMA 4IECA 1N51A 1XGNA 4ZWOA 2BWXA 4U1BA 1O0XA 2EVOA 4KM3A 2GU6A 4FLJA 3S6BA 1XGOA 4U76A 4U6ZA 2GGCA 1C24A 1R58A 1WN1A 3L7GA 1W2MA 2G6PA 2GGBA 3Q6DA 4Z7MA 5D6EA 5CDVA 2V6CA 4ZNGA 1QXYA 2OAZA 2NQ6A 5FCFA 1WL9A 2B3HA 1KP0A 3BIQA 1MATA 2B3LA 3L24A 4FLLA 1YW9A 3IG4A 1C21A 4RZZA 1XNZA 5CE6A 4PV4A 4B28A 3PKCA 4IDYA 3BIPA 2DFIA 5E5BA 5FCHA 1CHMA 4U70A 2BHDA 2BHBA 3MR1A 2GTXA 3IU7A 1QXZA 2GG5A 3IU8A 5CDEA 2BWVA 4U69A 4A6VA 2BH3A 2BWWA 3MX6A 4IKUA 4PNCA 1BOAA 1XGSA 2GG0A 1R5GA 4A6WA 4JUQA 1WKMA 4U71A 1A16A 1Y1NA 2BWUA 4U75A 1B59A 2P98A 1C27A 2GG2A 1WLRA 3CB5A 2EA4A 2Q96A 1M35A 1PV9A 2GG7A 3TB5A 5CLSA 1YW8A 2BWSA 2GG3A 3CTZA 1C22A 3FM3A 2BN7A 3MATA 2GG9A 4RGZ1 1W7VA 4S01A 5CDLA 2GA2A 3RORA 4EGEA 2IW2A 3PKAA 3BITA 1R5HA 2B3KA 1WL6A 4S2RP 4QR8A 4FLIA 3RVAA 2Q93A 2BWTA 1KQ9A 4U6EA 2HOWA 2NQ7A 4IPAA 2GU7A 5CIKA 2P9AA 1BN5A 3TAVA 4IKSA 2BWYA 2BHAA 3PKEA 2Q95A 4FUKA 1WY2A 2ADUA 4OOKA 1YJ3A 4U6WA 4U6CA 4FO7A 4ZWPA 3IU9A 2Q8KA 1QXWA 2MATA 4IF7A 4IU6A 3D27A 2V3YA 4MATA 1JAWA 1QZYA 2Q92A 1C23A 5CNXA 1KQ0A 4FO8A 5JI6A 3FMRA 4HXXA 2BHCA 4U73A 1YW7A 2EVCA 2OKNA 2GZ5A 1B6AA 4ZWUA 1WBQA 4S2TP 3CB6A 3PKBA 4FKCA 2GU4A 4U6JA 1XGMA 2Q94A 5D6FA 2V3ZA 4IKTA 4S00A 2GG8A 2GU5A 2EVMA 5JHUA 4RZYA 4IKRA 2EA2A 5JFRA 3PKDA 4R60A 3FMQA 2V3XA 2P99A 2ZSGA
chains in the Genus database with same CATH topology
4FLKA 2BB7A 1YVMA 4IECA 1N51A 1XGNA 4ZWOA 2BWXA 4U1BA 1O0XA 2EVOA 4KM3A 2GU6A 4FLJA 3S6BA 1XGOA 4U76A 4U6ZA 2GGCA 1C24A 1R58A 1WN1A 3L7GA 1W2MA 2G6PA 2GGBA 3Q6DA 4Z7MA 5D6EA 5CDVA 2V6CA 4ZNGA 1QXYA 2OAZA 2NQ6A 5FCFA 1WL9A 2B3HA 1KP0A 3BIQA 1MATA 2B3LA 3L24A 4FLLA 1YW9A 3IG4A 1C21A 4RZZA 1XNZA 5CE6A 4PV4A 4B28A 3PKCA 4IDYA 3BIPA 2DFIA 5E5BA 5FCHA 1CHMA 4U70A 2BHDA 2BHBA 3MR1A 2GTXA 3IU7A 1QXZA 2GG5A 3IU8A 5CDEA 2BWVA 4U69A 4A6VA 2BH3A 2BWWA 3MX6A 4IKUA 4PNCA 1BOAA 1XGSA 2GG0A 1R5GA 4A6WA 4JUQA 1WKMA 4U71A 1A16A 1Y1NA 2BWUA 4U75A 1B59A 2P98A 1C27A 2GG2A 1WLRA 3CB5A 2EA4A 2Q96A 1M35A 1PV9A 2GG7A 3TB5A 5CLSA 1YW8A 2BWSA 2GG3A 3CTZA 1C22A 3FM3A 2BN7A 3MATA 2GG9A 4RGZ1 1W7VA 4S01A 5CDLA 2GA2A 3RORA 4EGEA 2IW2A 3PKAA 3BITA 1R5HA 2B3KA 1WL6A 4S2RP 4QR8A 4FLIA 3RVAA 2Q93A 2BWTA 1KQ9A 4U6EA 2HOWA 2NQ7A 4IPAA 2GU7A 5CIKA 2P9AA 1BN5A 3TAVA 4IKSA 2BWYA 2BHAA 3PKEA 2Q95A 4FUKA 1WY2A 2ADUA 4OOKA 1YJ3A 4U6WA 4U6CA 4FO7A 4ZWPA 3IU9A 2Q8KA 1QXWA 2MATA 4IF7A 4IU6A 3D27A 2V3YA 4MATA 1JAWA 1QZYA 2Q92A 1C23A 5CNXA 1KQ0A 4FO8A 5JI6A 3FMRA 4HXXA 2BHCA 4U73A 1YW7A 2EVCA 2OKNA 2GZ5A 1B6AA 4ZWUA 1WBQA 4S2TP 3CB6A 3PKBA 4FKCA 2GU4A 4U6JA 1XGMA 2Q94A 5D6FA 2V3ZA 4IKTA 4S00A 2GG8A 2GU5A 2EVMA 5JHUA 4RZYA 4IKRA 2EA2A 5JFRA 3PKDA 4R60A 3FMQA 2V3XA 2P99A 2ZSGA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4FLK A;  2BB7 A;  1YVM A;  4IEC A;  1N51 A;  1XGN A;  4ZWO A;  2BWX A;  4U1B A;  1O0X A;  2EVO A;  4KM3 A;  2GU6 A;  4FLJ A;  3S6B A;  1XGO A;  4U76 A;  4U6Z A;  2GGC A;  1C24 A;  1R58 A;  1WN1 A;  3L7G A;  1W2M A;  2G6P A;  2GGB A;  3Q6D A;  4Z7M A;  5D6E A;  5CDV A;  2V6C A;  4ZNG A;  1QXY A;  2OAZ A;  2NQ6 A;  5FCF A;  1WL9 A;  2B3H A;  1KP0 A;  3BIQ A;  1MAT A;  2B3L A;  3L24 A;  4FLL A;  1YW9 A;  3IG4 A;  1C21 A;  4RZZ A;  1XNZ A;  5CE6 A;  4PV4 A;  4B28 A;  3PKC A;  4IDY A;  3BIP A;  2DFI A;  5E5B A;  5FCH A;  1CHM A;  4U70 A;  2BHD A;  2BHB A;  3MR1 A;  2GTX A;  3IU7 A;  1QXZ A;  2GG5 A;  3IU8 A;  5CDE A;  2BWV A;  4U69 A;  4A6V A;  2BH3 A;  2BWW A;  3MX6 A;  4IKU A;  4PNC A;  1BOA A;  1XGS A;  2GG0 A;  1R5G A;  4A6W A;  4JUQ A;  1WKM A;  4U71 A;  1A16 A;  1Y1N A;  2BWU A;  4U75 A;  1B59 A;  2P98 A;  1C27 A;  2GG2 A;  1WLR A;  3CB5 A;  2EA4 A;  2Q96 A;  1M35 A;  1PV9 A;  2GG7 A;  3TB5 A;  5CLS A;  1YW8 A;  2BWS A;  2GG3 A;  3CTZ A;  1C22 A;  3FM3 A;  2BN7 A;  3MAT A;  2GG9 A;  4RGZ 1;  1W7V A;  4S01 A;  5CDL A;  2GA2 A;  3ROR A;  4EGE A;  2IW2 A;  3PKA A;  3BIT A;  1R5H A;  2B3K A;  1WL6 A;  4S2R P;  4QR8 A;  4FLI A;  3RVA A;  2Q93 A;  2BWT A;  1KQ9 A;  4U6E A;  2HOW A;  2NQ7 A;  4IPA A;  2GU7 A;  5CIK A;  2P9A A;  1BN5 A;  3TAV A;  4IKS A;  2BWY A;  2BHA A;  3PKE A;  2Q95 A;  4FUK A;  1WY2 A;  2ADU A;  4OOK A;  1YJ3 A;  4U6W A;  4U6C A;  4FO7 A;  4ZWP A;  3IU9 A;  2Q8K A;  1QXW A;  2MAT A;  4IF7 A;  4IU6 A;  3D27 A;  2V3Y A;  4MAT A;  1JAW A;  1QZY A;  2Q92 A;  1C23 A;  5CNX A;  1KQ0 A;  4FO8 A;  5JI6 A;  3FMR A;  4HXX A;  2BHC A;  4U73 A;  1YW7 A;  2EVC A;  2OKN A;  2GZ5 A;  1B6A A;  4ZWU A;  1WBQ A;  4S2T P;  3CB6 A;  3PKB A;  4FKC A;  2GU4 A;  4U6J A;  1XGM A;  2Q94 A;  5D6F A;  2V3Z A;  4IKT A;  4S00 A;  2GG8 A;  2GU5 A;  2EVM A;  5JHU A;  4RZY A;  4IKR A;  2EA2 A;  5JFR A;  3PKD A;  4R60 A;  3FMQ A;  2V3X A;  2P99 A;  2ZSG A; 
#chains in the Genus database with same CATH topology
 4FLK A;  2BB7 A;  1YVM A;  4IEC A;  1N51 A;  1XGN A;  4ZWO A;  2BWX A;  4U1B A;  1O0X A;  2EVO A;  4KM3 A;  2GU6 A;  4FLJ A;  3S6B A;  1XGO A;  4U76 A;  4U6Z A;  2GGC A;  1C24 A;  1R58 A;  1WN1 A;  3L7G A;  1W2M A;  2G6P A;  2GGB A;  3Q6D A;  4Z7M A;  5D6E A;  5CDV A;  2V6C A;  4ZNG A;  1QXY A;  2OAZ A;  2NQ6 A;  5FCF A;  1WL9 A;  2B3H A;  1KP0 A;  3BIQ A;  1MAT A;  2B3L A;  3L24 A;  4FLL A;  1YW9 A;  3IG4 A;  1C21 A;  4RZZ A;  1XNZ A;  5CE6 A;  4PV4 A;  4B28 A;  3PKC A;  4IDY A;  3BIP A;  2DFI A;  5E5B A;  5FCH A;  1CHM A;  4U70 A;  2BHD A;  2BHB A;  3MR1 A;  2GTX A;  3IU7 A;  1QXZ A;  2GG5 A;  3IU8 A;  5CDE A;  2BWV A;  4U69 A;  4A6V A;  2BH3 A;  2BWW A;  3MX6 A;  4IKU A;  4PNC A;  1BOA A;  1XGS A;  2GG0 A;  1R5G A;  4A6W A;  4JUQ A;  1WKM A;  4U71 A;  1A16 A;  1Y1N A;  2BWU A;  4U75 A;  1B59 A;  2P98 A;  1C27 A;  2GG2 A;  1WLR A;  3CB5 A;  2EA4 A;  2Q96 A;  1M35 A;  1PV9 A;  2GG7 A;  3TB5 A;  5CLS A;  1YW8 A;  2BWS A;  2GG3 A;  3CTZ A;  1C22 A;  3FM3 A;  2BN7 A;  3MAT A;  2GG9 A;  4RGZ 1;  1W7V A;  4S01 A;  5CDL A;  2GA2 A;  3ROR A;  4EGE A;  2IW2 A;  3PKA A;  3BIT A;  1R5H A;  2B3K A;  1WL6 A;  4S2R P;  4QR8 A;  4FLI A;  3RVA A;  2Q93 A;  2BWT A;  1KQ9 A;  4U6E A;  2HOW A;  2NQ7 A;  4IPA A;  2GU7 A;  5CIK A;  2P9A A;  1BN5 A;  3TAV A;  4IKS A;  2BWY A;  2BHA A;  3PKE A;  2Q95 A;  4FUK A;  1WY2 A;  2ADU A;  4OOK A;  1YJ3 A;  4U6W A;  4U6C A;  4FO7 A;  4ZWP A;  3IU9 A;  2Q8K A;  1QXW A;  2MAT A;  4IF7 A;  4IU6 A;  3D27 A;  2V3Y A;  4MAT A;  1JAW A;  1QZY A;  2Q92 A;  1C23 A;  5CNX A;  1KQ0 A;  4FO8 A;  5JI6 A;  3FMR A;  4HXX A;  2BHC A;  4U73 A;  1YW7 A;  2EVC A;  2OKN A;  2GZ5 A;  1B6A A;  4ZWU A;  1WBQ A;  4S2T P;  3CB6 A;  3PKB A;  4FKC A;  2GU4 A;  4U6J A;  1XGM A;  2Q94 A;  5D6F A;  2V3Z A;  4IKT A;  4S00 A;  2GG8 A;  2GU5 A;  2EVM A;  5JHU A;  4RZY A;  4IKR A;  2EA2 A;  5JFR A;  3PKD A;  4R60 A;  3FMQ A;  2V3X A;  2P99 A;  2ZSG A; 
#chains in the Genus database with same CATH homology
 4FLK A;  2BB7 A;  1YVM A;  4IEC A;  1N51 A;  1XGN A;  4ZWO A;  2BWX A;  4U1B A;  1O0X A;  2EVO A;  4KM3 A;  2GU6 A;  4FLJ A;  3S6B A;  1XGO A;  4U76 A;  4U6Z A;  2GGC A;  1C24 A;  1R58 A;  1WN1 A;  3L7G A;  1W2M A;  2G6P A;  2GGB A;  3Q6D A;  4Z7M A;  5D6E A;  5CDV A;  2V6C A;  4ZNG A;  1QXY A;  2OAZ A;  2NQ6 A;  5FCF A;  1WL9 A;  2B3H A;  1KP0 A;  3BIQ A;  1MAT A;  2B3L A;  3L24 A;  4FLL A;  1YW9 A;  3IG4 A;  1C21 A;  4RZZ A;  1XNZ A;  5CE6 A;  4PV4 A;  4B28 A;  3PKC A;  4IDY A;  3BIP A;  2DFI A;  5E5B A;  5FCH A;  1CHM A;  4U70 A;  2BHD A;  2BHB A;  3MR1 A;  2GTX A;  3IU7 A;  1QXZ A;  2GG5 A;  3IU8 A;  5CDE A;  2BWV A;  4U69 A;  4A6V A;  2BH3 A;  2BWW A;  3MX6 A;  4IKU A;  4PNC A;  1BOA A;  1XGS A;  2GG0 A;  1R5G A;  4A6W A;  4JUQ A;  1WKM A;  4U71 A;  1A16 A;  1Y1N A;  2BWU A;  4U75 A;  1B59 A;  2P98 A;  1C27 A;  2GG2 A;  1WLR A;  3CB5 A;  2EA4 A;  2Q96 A;  1M35 A;  1PV9 A;  2GG7 A;  3TB5 A;  5CLS A;  1YW8 A;  2BWS A;  2GG3 A;  3CTZ A;  1C22 A;  3FM3 A;  2BN7 A;  3MAT A;  2GG9 A;  4RGZ 1;  1W7V A;  4S01 A;  5CDL A;  2GA2 A;  3ROR A;  4EGE A;  2IW2 A;  3PKA A;  3BIT A;  1R5H A;  2B3K A;  1WL6 A;  4S2R P;  4QR8 A;  4FLI A;  3RVA A;  2Q93 A;  2BWT A;  1KQ9 A;  4U6E A;  2HOW A;  2NQ7 A;  4IPA A;  2GU7 A;  5CIK A;  2P9A A;  1BN5 A;  3TAV A;  4IKS A;  2BWY A;  2BHA A;  3PKE A;  2Q95 A;  4FUK A;  1WY2 A;  2ADU A;  4OOK A;  1YJ3 A;  4U6W A;  4U6C A;  4FO7 A;  4ZWP A;  3IU9 A;  2Q8K A;  1QXW A;  2MAT A;  4IF7 A;  4IU6 A;  3D27 A;  2V3Y A;  4MAT A;  1JAW A;  1QZY A;  2Q92 A;  1C23 A;  5CNX A;  1KQ0 A;  4FO8 A;  5JI6 A;  3FMR A;  4HXX A;  2BHC A;  4U73 A;  1YW7 A;  2EVC A;  2OKN A;  2GZ5 A;  1B6A A;  4ZWU A;  1WBQ A;  4S2T P;  3CB6 A;  3PKB A;  4FKC A;  2GU4 A;  4U6J A;  1XGM A;  2Q94 A;  5D6F A;  2V3Z A;  4IKT A;  4S00 A;  2GG8 A;  2GU5 A;  2EVM A;  5JHU A;  4RZY A;  4IKR A;  2EA2 A;  5JFR A;  3PKD A;  4R60 A;  3FMQ A;  2V3X A;  2P99 A;  2ZSG A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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