2GG7A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 85
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg7A00
4U69A 2GA2A 1WBQA 4U6ZA 4ZNGA 4FO8A 3PKDA 5FCFA 1C24A 2G6PA 3MATA 4HXXA 2EA4A 3BIPA 3MR1A 2GU5A 4S2TP 4FUKA 1W2MA 1QXWA 1XGMA 1YW9A 4IKTA 4ZWOA 4ZWUA 5CDLA 2B3HA 4S00A 2P99A 5CDVA 2GGBA 4ZWPA 3PKCA 3L7GA 5D6EA 2P9AA 3PKAA 4U70A 2NQ7A 2DFIA 1XGSA 2GTXA 2OKNA 2BWXA 4EGEA 1C22A 4U6EA 4PNCA 1MATA 1R5GA 5D6FA 1BOAA 5CIKA 2EA2A 4IKSA 1C27A 1N51A 4RZYA 1WN1A 2GU7A 2MATA 1YVMA 3CTZA 2IW2A 4U6WA 1KP0A 2V3YA 3TAVA 4IU6A 5JHUA 1YW7A 2P98A 1WLRA 3BITA 5FCHA 4U6JA 1QXZA 2EVOA 1XGOA 2BWUA 2Q95A 2BH3A 2GG9A 2GG5A 1WKMA 2GU6A 2B3KA 4RGZ1 1W7VA 3PKEA 3PKBA 5CE6A 1QXYA 4IECA 2BHCA 4MATA 4Z7MA 4RZZA 3IU9A 1BN5A 1O0XA 3RVAA 3Q6DA 2V3ZA 5E5BA 4U6CA 2OAZA 2BWYA 2GU4A 4U75A 1B6AA 2HOWA 2V3XA 2GG7A 2BHDA 1PV9A 3CB6A 4FKCA 4U73A 3S6BA 1YW8A 2ZSGA 3FMRA 2BHBA 2NQ6A 1WL6A 4FLKA 5JFRA 1Y1NA 2Q92A 4IKRA 2GG3A 1KQ0A 3IU7A 2BN7A 2BWWA 4U76A 3TB5A 4QR8A 4PV4A 3D27A 3MX6A 5CNXA 1KQ9A 3CB5A 4U71A 4IF7A 2B3LA 2GG0A 1WL9A 1M35A 3L24A 4IKUA 4KM3A 4OOKA 2Q8KA 3RORA 2BHAA 2BWVA 4FO7A 4R60A 2V6CA 1B59A 3IU8A 2BWSA 2BWTA 5CDEA 5CLSA 3FM3A 1WY2A 2Q93A 4FLJA 4S01A 1JAWA 1XNZA 1R5HA 4JUQA 4B28A 2BB7A 3IG4A 2ADUA 2GG8A 2Q96A 4IPAA 4S2RP 3BIQA 1C23A 1C21A 4U1BA 4FLLA 2EVMA 2GGCA 2GG2A 4IDYA 2Q94A 1A16A 1XGNA 1YJ3A 1QZYA 1R58A 2EVCA 4A6VA 1CHMA 4FLIA 3FMQA 5JI6A 2GZ5A 4A6WA
chains in the Genus database with same CATH superfamily
4U69A 2GA2A 1WBQA 4U6ZA 4ZNGA 4FO8A 3PKDA 5FCFA 1C24A 2G6PA 3MATA 4HXXA 2EA4A 3BIPA 3MR1A 2GU5A 4S2TP 4FUKA 1W2MA 1QXWA 1XGMA 1YW9A 4IKTA 4ZWOA 4ZWUA 5CDLA 2B3HA 4S00A 2P99A 5CDVA 2GGBA 4ZWPA 3PKCA 3L7GA 5D6EA 2P9AA 3PKAA 4U70A 2NQ7A 2DFIA 1XGSA 2GTXA 2OKNA 2BWXA 4EGEA 1C22A 4U6EA 4PNCA 1MATA 1R5GA 5D6FA 1BOAA 5CIKA 2EA2A 4IKSA 1C27A 1N51A 4RZYA 1WN1A 2GU7A 2MATA 1YVMA 3CTZA 2IW2A 4U6WA 1KP0A 2V3YA 3TAVA 4IU6A 5JHUA 1YW7A 2P98A 1WLRA 3BITA 5FCHA 4U6JA 1QXZA 2EVOA 1XGOA 2BWUA 2Q95A 2BH3A 2GG9A 2GG5A 1WKMA 2GU6A 2B3KA 4RGZ1 1W7VA 3PKEA 3PKBA 5CE6A 1QXYA 4IECA 2BHCA 4MATA 4Z7MA 4RZZA 3IU9A 1BN5A 1O0XA 3RVAA 3Q6DA 2V3ZA 5E5BA 4U6CA 2OAZA 2BWYA 2GU4A 4U75A 1B6AA 2HOWA 2V3XA 2GG7A 2BHDA 1PV9A 3CB6A 4FKCA 4U73A 3S6BA 1YW8A 2ZSGA 3FMRA 2BHBA 2NQ6A 1WL6A 4FLKA 5JFRA 1Y1NA 2Q92A 4IKRA 2GG3A 1KQ0A 3IU7A 2BN7A 2BWWA 4U76A 3TB5A 4QR8A 4PV4A 3D27A 3MX6A 5CNXA 1KQ9A 3CB5A 4U71A 4IF7A 2B3LA 2GG0A 1WL9A 1M35A 3L24A 4IKUA 4KM3A 4OOKA 2Q8KA 3RORA 2BHAA 2BWVA 4FO7A 4R60A 2V6CA 1B59A 3IU8A 2BWSA 2BWTA 5CDEA 5CLSA 3FM3A 1WY2A 2Q93A 4FLJA 4S01A 1JAWA 1XNZA 1R5HA 4JUQA 4B28A 2BB7A 3IG4A 2ADUA 2GG8A 2Q96A 4IPAA 4S2RP 3BIQA 1C23A 1C21A 4U1BA 4FLLA 2EVMA 2GGCA 2GG2A 4IDYA 2Q94A 1A16A 1XGNA 1YJ3A 1QZYA 1R58A 2EVCA 4A6VA 1CHMA 4FLIA 3FMQA 5JI6A 2GZ5A 4A6WA
chains in the Genus database with same CATH topology
4U69A 2GA2A 1WBQA 4U6ZA 4ZNGA 4FO8A 3PKDA 5FCFA 1C24A 2G6PA 3MATA 4HXXA 2EA4A 3BIPA 3MR1A 2GU5A 4S2TP 4FUKA 1W2MA 1QXWA 1XGMA 1YW9A 4IKTA 4ZWOA 4ZWUA 5CDLA 2B3HA 4S00A 2P99A 5CDVA 2GGBA 4ZWPA 3PKCA 3L7GA 5D6EA 2P9AA 3PKAA 4U70A 2NQ7A 2DFIA 1XGSA 2GTXA 2OKNA 2BWXA 4EGEA 1C22A 4U6EA 4PNCA 1MATA 1R5GA 5D6FA 1BOAA 5CIKA 2EA2A 4IKSA 1C27A 1N51A 4RZYA 1WN1A 2GU7A 2MATA 1YVMA 3CTZA 2IW2A 4U6WA 1KP0A 2V3YA 3TAVA 4IU6A 5JHUA 1YW7A 2P98A 1WLRA 3BITA 5FCHA 4U6JA 1QXZA 2EVOA 1XGOA 2BWUA 2Q95A 2BH3A 2GG9A 2GG5A 1WKMA 2GU6A 2B3KA 4RGZ1 1W7VA 3PKEA 3PKBA 5CE6A 1QXYA 4IECA 2BHCA 4MATA 4Z7MA 4RZZA 3IU9A 1BN5A 1O0XA 3RVAA 3Q6DA 2V3ZA 5E5BA 4U6CA 2OAZA 2BWYA 2GU4A 4U75A 1B6AA 2HOWA 2V3XA 2GG7A 2BHDA 1PV9A 3CB6A 4FKCA 4U73A 3S6BA 1YW8A 2ZSGA 3FMRA 2BHBA 2NQ6A 1WL6A 4FLKA 5JFRA 1Y1NA 2Q92A 4IKRA 2GG3A 1KQ0A 3IU7A 2BN7A 2BWWA 4U76A 3TB5A 4QR8A 4PV4A 3D27A 3MX6A 5CNXA 1KQ9A 3CB5A 4U71A 4IF7A 2B3LA 2GG0A 1WL9A 1M35A 3L24A 4IKUA 4KM3A 4OOKA 2Q8KA 3RORA 2BHAA 2BWVA 4FO7A 4R60A 2V6CA 1B59A 3IU8A 2BWSA 2BWTA 5CDEA 5CLSA 3FM3A 1WY2A 2Q93A 4FLJA 4S01A 1JAWA 1XNZA 1R5HA 4JUQA 4B28A 2BB7A 3IG4A 2ADUA 2GG8A 2Q96A 4IPAA 4S2RP 3BIQA 1C23A 1C21A 4U1BA 4FLLA 2EVMA 2GGCA 2GG2A 4IDYA 2Q94A 1A16A 1XGNA 1YJ3A 1QZYA 1R58A 2EVCA 4A6VA 1CHMA 4FLIA 3FMQA 5JI6A 2GZ5A 4A6WA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4U69 A;  2GA2 A;  1WBQ A;  4U6Z A;  4ZNG A;  4FO8 A;  3PKD A;  5FCF A;  1C24 A;  2G6P A;  3MAT A;  4HXX A;  2EA4 A;  3BIP A;  3MR1 A;  2GU5 A;  4S2T P;  4FUK A;  1W2M A;  1QXW A;  1XGM A;  1YW9 A;  4IKT A;  4ZWO A;  4ZWU A;  5CDL A;  2B3H A;  4S00 A;  2P99 A;  5CDV A;  2GGB A;  4ZWP A;  3PKC A;  3L7G A;  5D6E A;  2P9A A;  3PKA A;  4U70 A;  2NQ7 A;  2DFI A;  1XGS A;  2GTX A;  2OKN A;  2BWX A;  4EGE A;  1C22 A;  4U6E A;  4PNC A;  1MAT A;  1R5G A;  5D6F A;  1BOA A;  5CIK A;  2EA2 A;  4IKS A;  1C27 A;  1N51 A;  4RZY A;  1WN1 A;  2GU7 A;  2MAT A;  1YVM A;  3CTZ A;  2IW2 A;  4U6W A;  1KP0 A;  2V3Y A;  3TAV A;  4IU6 A;  5JHU A;  1YW7 A;  2P98 A;  1WLR A;  3BIT A;  5FCH A;  4U6J A;  1QXZ A;  2EVO A;  1XGO A;  2BWU A;  2Q95 A;  2BH3 A;  2GG9 A;  2GG5 A;  1WKM A;  2GU6 A;  2B3K A;  4RGZ 1;  1W7V A;  3PKE A;  3PKB A;  5CE6 A;  1QXY A;  4IEC A;  2BHC A;  4MAT A;  4Z7M A;  4RZZ A;  3IU9 A;  1BN5 A;  1O0X A;  3RVA A;  3Q6D A;  2V3Z A;  5E5B A;  4U6C A;  2OAZ A;  2BWY A;  2GU4 A;  4U75 A;  1B6A A;  2HOW A;  2V3X A;  2GG7 A;  2BHD A;  1PV9 A;  3CB6 A;  4FKC A;  4U73 A;  3S6B A;  1YW8 A;  2ZSG A;  3FMR A;  2BHB A;  2NQ6 A;  1WL6 A;  4FLK A;  5JFR A;  1Y1N A;  2Q92 A;  4IKR A;  2GG3 A;  1KQ0 A;  3IU7 A;  2BN7 A;  2BWW A;  4U76 A;  3TB5 A;  4QR8 A;  4PV4 A;  3D27 A;  3MX6 A;  5CNX A;  1KQ9 A;  3CB5 A;  4U71 A;  4IF7 A;  2B3L A;  2GG0 A;  1WL9 A;  1M35 A;  3L24 A;  4IKU A;  4KM3 A;  4OOK A;  2Q8K A;  3ROR A;  2BHA A;  2BWV A;  4FO7 A;  4R60 A;  2V6C A;  1B59 A;  3IU8 A;  2BWS A;  2BWT A;  5CDE A;  5CLS A;  3FM3 A;  1WY2 A;  2Q93 A;  4FLJ A;  4S01 A;  1JAW A;  1XNZ A;  1R5H A;  4JUQ A;  4B28 A;  2BB7 A;  3IG4 A;  2ADU A;  2GG8 A;  2Q96 A;  4IPA A;  4S2R P;  3BIQ A;  1C23 A;  1C21 A;  4U1B A;  4FLL A;  2EVM A;  2GGC A;  2GG2 A;  4IDY A;  2Q94 A;  1A16 A;  1XGN A;  1YJ3 A;  1QZY A;  1R58 A;  2EVC A;  4A6V A;  1CHM A;  4FLI A;  3FMQ A;  5JI6 A;  2GZ5 A;  4A6W A; 
#chains in the Genus database with same CATH topology
 4U69 A;  2GA2 A;  1WBQ A;  4U6Z A;  4ZNG A;  4FO8 A;  3PKD A;  5FCF A;  1C24 A;  2G6P A;  3MAT A;  4HXX A;  2EA4 A;  3BIP A;  3MR1 A;  2GU5 A;  4S2T P;  4FUK A;  1W2M A;  1QXW A;  1XGM A;  1YW9 A;  4IKT A;  4ZWO A;  4ZWU A;  5CDL A;  2B3H A;  4S00 A;  2P99 A;  5CDV A;  2GGB A;  4ZWP A;  3PKC A;  3L7G A;  5D6E A;  2P9A A;  3PKA A;  4U70 A;  2NQ7 A;  2DFI A;  1XGS A;  2GTX A;  2OKN A;  2BWX A;  4EGE A;  1C22 A;  4U6E A;  4PNC A;  1MAT A;  1R5G A;  5D6F A;  1BOA A;  5CIK A;  2EA2 A;  4IKS A;  1C27 A;  1N51 A;  4RZY A;  1WN1 A;  2GU7 A;  2MAT A;  1YVM A;  3CTZ A;  2IW2 A;  4U6W A;  1KP0 A;  2V3Y A;  3TAV A;  4IU6 A;  5JHU A;  1YW7 A;  2P98 A;  1WLR A;  3BIT A;  5FCH A;  4U6J A;  1QXZ A;  2EVO A;  1XGO A;  2BWU A;  2Q95 A;  2BH3 A;  2GG9 A;  2GG5 A;  1WKM A;  2GU6 A;  2B3K A;  4RGZ 1;  1W7V A;  3PKE A;  3PKB A;  5CE6 A;  1QXY A;  4IEC A;  2BHC A;  4MAT A;  4Z7M A;  4RZZ A;  3IU9 A;  1BN5 A;  1O0X A;  3RVA A;  3Q6D A;  2V3Z A;  5E5B A;  4U6C A;  2OAZ A;  2BWY A;  2GU4 A;  4U75 A;  1B6A A;  2HOW A;  2V3X A;  2GG7 A;  2BHD A;  1PV9 A;  3CB6 A;  4FKC A;  4U73 A;  3S6B A;  1YW8 A;  2ZSG A;  3FMR A;  2BHB A;  2NQ6 A;  1WL6 A;  4FLK A;  5JFR A;  1Y1N A;  2Q92 A;  4IKR A;  2GG3 A;  1KQ0 A;  3IU7 A;  2BN7 A;  2BWW A;  4U76 A;  3TB5 A;  4QR8 A;  4PV4 A;  3D27 A;  3MX6 A;  5CNX A;  1KQ9 A;  3CB5 A;  4U71 A;  4IF7 A;  2B3L A;  2GG0 A;  1WL9 A;  1M35 A;  3L24 A;  4IKU A;  4KM3 A;  4OOK A;  2Q8K A;  3ROR A;  2BHA A;  2BWV A;  4FO7 A;  4R60 A;  2V6C A;  1B59 A;  3IU8 A;  2BWS A;  2BWT A;  5CDE A;  5CLS A;  3FM3 A;  1WY2 A;  2Q93 A;  4FLJ A;  4S01 A;  1JAW A;  1XNZ A;  1R5H A;  4JUQ A;  4B28 A;  2BB7 A;  3IG4 A;  2ADU A;  2GG8 A;  2Q96 A;  4IPA A;  4S2R P;  3BIQ A;  1C23 A;  1C21 A;  4U1B A;  4FLL A;  2EVM A;  2GGC A;  2GG2 A;  4IDY A;  2Q94 A;  1A16 A;  1XGN A;  1YJ3 A;  1QZY A;  1R58 A;  2EVC A;  4A6V A;  1CHM A;  4FLI A;  3FMQ A;  5JI6 A;  2GZ5 A;  4A6W A; 
#chains in the Genus database with same CATH homology
 4U69 A;  2GA2 A;  1WBQ A;  4U6Z A;  4ZNG A;  4FO8 A;  3PKD A;  5FCF A;  1C24 A;  2G6P A;  3MAT A;  4HXX A;  2EA4 A;  3BIP A;  3MR1 A;  2GU5 A;  4S2T P;  4FUK A;  1W2M A;  1QXW A;  1XGM A;  1YW9 A;  4IKT A;  4ZWO A;  4ZWU A;  5CDL A;  2B3H A;  4S00 A;  2P99 A;  5CDV A;  2GGB A;  4ZWP A;  3PKC A;  3L7G A;  5D6E A;  2P9A A;  3PKA A;  4U70 A;  2NQ7 A;  2DFI A;  1XGS A;  2GTX A;  2OKN A;  2BWX A;  4EGE A;  1C22 A;  4U6E A;  4PNC A;  1MAT A;  1R5G A;  5D6F A;  1BOA A;  5CIK A;  2EA2 A;  4IKS A;  1C27 A;  1N51 A;  4RZY A;  1WN1 A;  2GU7 A;  2MAT A;  1YVM A;  3CTZ A;  2IW2 A;  4U6W A;  1KP0 A;  2V3Y A;  3TAV A;  4IU6 A;  5JHU A;  1YW7 A;  2P98 A;  1WLR A;  3BIT A;  5FCH A;  4U6J A;  1QXZ A;  2EVO A;  1XGO A;  2BWU A;  2Q95 A;  2BH3 A;  2GG9 A;  2GG5 A;  1WKM A;  2GU6 A;  2B3K A;  4RGZ 1;  1W7V A;  3PKE A;  3PKB A;  5CE6 A;  1QXY A;  4IEC A;  2BHC A;  4MAT A;  4Z7M A;  4RZZ A;  3IU9 A;  1BN5 A;  1O0X A;  3RVA A;  3Q6D A;  2V3Z A;  5E5B A;  4U6C A;  2OAZ A;  2BWY A;  2GU4 A;  4U75 A;  1B6A A;  2HOW A;  2V3X A;  2GG7 A;  2BHD A;  1PV9 A;  3CB6 A;  4FKC A;  4U73 A;  3S6B A;  1YW8 A;  2ZSG A;  3FMR A;  2BHB A;  2NQ6 A;  1WL6 A;  4FLK A;  5JFR A;  1Y1N A;  2Q92 A;  4IKR A;  2GG3 A;  1KQ0 A;  3IU7 A;  2BN7 A;  2BWW A;  4U76 A;  3TB5 A;  4QR8 A;  4PV4 A;  3D27 A;  3MX6 A;  5CNX A;  1KQ9 A;  3CB5 A;  4U71 A;  4IF7 A;  2B3L A;  2GG0 A;  1WL9 A;  1M35 A;  3L24 A;  4IKU A;  4KM3 A;  4OOK A;  2Q8K A;  3ROR A;  2BHA A;  2BWV A;  4FO7 A;  4R60 A;  2V6C A;  1B59 A;  3IU8 A;  2BWS A;  2BWT A;  5CDE A;  5CLS A;  3FM3 A;  1WY2 A;  2Q93 A;  4FLJ A;  4S01 A;  1JAW A;  1XNZ A;  1R5H A;  4JUQ A;  4B28 A;  2BB7 A;  3IG4 A;  2ADU A;  2GG8 A;  2Q96 A;  4IPA A;  4S2R P;  3BIQ A;  1C23 A;  1C21 A;  4U1B A;  4FLL A;  2EVM A;  2GGC A;  2GG2 A;  4IDY A;  2Q94 A;  1A16 A;  1XGN A;  1YJ3 A;  1QZY A;  1R58 A;  2EVC A;  4A6V A;  1CHM A;  4FLI A;  3FMQ A;  5JI6 A;  2GZ5 A;  4A6W A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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