2GG8A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 88
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg8A00
4Z7MA 4HXXA 2BHBA 1W2MA 1WKMA 1QXYA 3PKEA 3CTZA 2GG5A 2GG9A 3FM3A 4IKTA 4MATA 4FUKA 1B59A 5E5BA 4RZYA 2EA4A 4FLKA 4U76A 3PKBA 4U69A 1MATA 1BOAA 5CIKA 3S6BA 3L7GA 2GU5A 2B3LA 4RGZ1 3BITA 3CB5A 5CDLA 4U70A 1WL6A 2BWWA 4IF7A 2OKNA 1YJ3A 1YW7A 2BWTA 4RZZA 3D27A 1YVMA 2GA2A 3MX6A 2GU7A 1KP0A 1KQ9A 1R5HA 2ZSGA 3TAVA 1C23A 1A16A 2BWUA 3IU7A 2GGCA 2BWSA 1QXZA 1XGOA 2Q93A 4FO7A 4IPAA 2BWXA 1QXWA 3PKAA 4QR8A 2ADUA 3MATA 5FCHA 2MATA 1WL9A 4KM3A 1YW9A 4U1BA 1PV9A 1WLRA 1C22A 5D6FA 2HOWA 2Q96A 1KQ0A 1WY2A 4U6CA 2GTXA 4A6WA 2GG8A 5JHUA 3TB5A 4IKSA 4ZNGA 4R60A 4IDYA 2V3ZA 1C24A 2BH3A 2NQ7A 3FMRA 2G6PA 1N51A 2BHCA 2BN7A 3BIQA 2GZ5A 4U6JA 2GG2A 2GU4A 4IKUA 2BHDA 3PKDA 1BN5A 5CLSA 1W7VA 1JAWA 2EVCA 3CB6A 5JI6A 4U75A 2B3HA 4A6VA 4U6EA 3L24A 4U73A 2DFIA 3PKCA 2EA2A 4ZWUA 4FLLA 2BB7A 1C27A 4S2RP 2P9AA 2Q8KA 1XNZA 4FLIA 3RORA 3BIPA 1XGMA 2P98A 1Y1NA 1O0XA 2EVMA 5D6EA 1XGNA 2GG3A 4S2TP 4U6ZA 1R58A 4IECA 1C21A 3IG4A 5FCFA 1M35A 4FLJA 4ZWPA 2OAZA 2GG0A 4FO8A 2BWVA 5CE6A 2GU6A 1WN1A 1WBQA 2EVOA 2B3KA 2BWYA 3IU9A 4B28A 4PV4A 3Q6DA 2Q95A 4U6WA 2GGBA 5CDVA 3IU8A 4JUQA 3MR1A 4ZWOA 4EGEA 2V3XA 4OOKA 1B6AA 1YW8A 2NQ6A 4IKRA 4FKCA 4S01A 5CDEA 5JFRA 4PNCA 2V6CA 1CHMA 4U71A 1XGSA 2IW2A 2Q94A 2BHAA 4S00A 1QZYA 3FMQA 2P99A 2V3YA 2GG7A 3RVAA 4IU6A 5CNXA 1R5GA 2Q92A
chains in the Genus database with same CATH superfamily
4Z7MA 4HXXA 2BHBA 1W2MA 1WKMA 1QXYA 3PKEA 3CTZA 2GG5A 2GG9A 3FM3A 4IKTA 4MATA 4FUKA 1B59A 5E5BA 4RZYA 2EA4A 4FLKA 4U76A 3PKBA 4U69A 1MATA 1BOAA 5CIKA 3S6BA 3L7GA 2GU5A 2B3LA 4RGZ1 3BITA 3CB5A 5CDLA 4U70A 1WL6A 2BWWA 4IF7A 2OKNA 1YJ3A 1YW7A 2BWTA 4RZZA 3D27A 1YVMA 2GA2A 3MX6A 2GU7A 1KP0A 1KQ9A 1R5HA 2ZSGA 3TAVA 1C23A 1A16A 2BWUA 3IU7A 2GGCA 2BWSA 1QXZA 1XGOA 2Q93A 4FO7A 4IPAA 2BWXA 1QXWA 3PKAA 4QR8A 2ADUA 3MATA 5FCHA 2MATA 1WL9A 4KM3A 1YW9A 4U1BA 1PV9A 1WLRA 1C22A 5D6FA 2HOWA 2Q96A 1KQ0A 1WY2A 4U6CA 2GTXA 4A6WA 2GG8A 5JHUA 3TB5A 4IKSA 4ZNGA 4R60A 4IDYA 2V3ZA 1C24A 2BH3A 2NQ7A 3FMRA 2G6PA 1N51A 2BHCA 2BN7A 3BIQA 2GZ5A 4U6JA 2GG2A 2GU4A 4IKUA 2BHDA 3PKDA 1BN5A 5CLSA 1W7VA 1JAWA 2EVCA 3CB6A 5JI6A 4U75A 2B3HA 4A6VA 4U6EA 3L24A 4U73A 2DFIA 3PKCA 2EA2A 4ZWUA 4FLLA 2BB7A 1C27A 4S2RP 2P9AA 2Q8KA 1XNZA 4FLIA 3RORA 3BIPA 1XGMA 2P98A 1Y1NA 1O0XA 2EVMA 5D6EA 1XGNA 2GG3A 4S2TP 4U6ZA 1R58A 4IECA 1C21A 3IG4A 5FCFA 1M35A 4FLJA 4ZWPA 2OAZA 2GG0A 4FO8A 2BWVA 5CE6A 2GU6A 1WN1A 1WBQA 2EVOA 2B3KA 2BWYA 3IU9A 4B28A 4PV4A 3Q6DA 2Q95A 4U6WA 2GGBA 5CDVA 3IU8A 4JUQA 3MR1A 4ZWOA 4EGEA 2V3XA 4OOKA 1B6AA 1YW8A 2NQ6A 4IKRA 4FKCA 4S01A 5CDEA 5JFRA 4PNCA 2V6CA 1CHMA 4U71A 1XGSA 2IW2A 2Q94A 2BHAA 4S00A 1QZYA 3FMQA 2P99A 2V3YA 2GG7A 3RVAA 4IU6A 5CNXA 1R5GA 2Q92A
chains in the Genus database with same CATH topology
4Z7MA 4HXXA 2BHBA 1W2MA 1WKMA 1QXYA 3PKEA 3CTZA 2GG5A 2GG9A 3FM3A 4IKTA 4MATA 4FUKA 1B59A 5E5BA 4RZYA 2EA4A 4FLKA 4U76A 3PKBA 4U69A 1MATA 1BOAA 5CIKA 3S6BA 3L7GA 2GU5A 2B3LA 4RGZ1 3BITA 3CB5A 5CDLA 4U70A 1WL6A 2BWWA 4IF7A 2OKNA 1YJ3A 1YW7A 2BWTA 4RZZA 3D27A 1YVMA 2GA2A 3MX6A 2GU7A 1KP0A 1KQ9A 1R5HA 2ZSGA 3TAVA 1C23A 1A16A 2BWUA 3IU7A 2GGCA 2BWSA 1QXZA 1XGOA 2Q93A 4FO7A 4IPAA 2BWXA 1QXWA 3PKAA 4QR8A 2ADUA 3MATA 5FCHA 2MATA 1WL9A 4KM3A 1YW9A 4U1BA 1PV9A 1WLRA 1C22A 5D6FA 2HOWA 2Q96A 1KQ0A 1WY2A 4U6CA 2GTXA 4A6WA 2GG8A 5JHUA 3TB5A 4IKSA 4ZNGA 4R60A 4IDYA 2V3ZA 1C24A 2BH3A 2NQ7A 3FMRA 2G6PA 1N51A 2BHCA 2BN7A 3BIQA 2GZ5A 4U6JA 2GG2A 2GU4A 4IKUA 2BHDA 3PKDA 1BN5A 5CLSA 1W7VA 1JAWA 2EVCA 3CB6A 5JI6A 4U75A 2B3HA 4A6VA 4U6EA 3L24A 4U73A 2DFIA 3PKCA 2EA2A 4ZWUA 4FLLA 2BB7A 1C27A 4S2RP 2P9AA 2Q8KA 1XNZA 4FLIA 3RORA 3BIPA 1XGMA 2P98A 1Y1NA 1O0XA 2EVMA 5D6EA 1XGNA 2GG3A 4S2TP 4U6ZA 1R58A 4IECA 1C21A 3IG4A 5FCFA 1M35A 4FLJA 4ZWPA 2OAZA 2GG0A 4FO8A 2BWVA 5CE6A 2GU6A 1WN1A 1WBQA 2EVOA 2B3KA 2BWYA 3IU9A 4B28A 4PV4A 3Q6DA 2Q95A 4U6WA 2GGBA 5CDVA 3IU8A 4JUQA 3MR1A 4ZWOA 4EGEA 2V3XA 4OOKA 1B6AA 1YW8A 2NQ6A 4IKRA 4FKCA 4S01A 5CDEA 5JFRA 4PNCA 2V6CA 1CHMA 4U71A 1XGSA 2IW2A 2Q94A 2BHAA 4S00A 1QZYA 3FMQA 2P99A 2V3YA 2GG7A 3RVAA 4IU6A 5CNXA 1R5GA 2Q92A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4Z7M A;  4HXX A;  2BHB A;  1W2M A;  1WKM A;  1QXY A;  3PKE A;  3CTZ A;  2GG5 A;  2GG9 A;  3FM3 A;  4IKT A;  4MAT A;  4FUK A;  1B59 A;  5E5B A;  4RZY A;  2EA4 A;  4FLK A;  4U76 A;  3PKB A;  4U69 A;  1MAT A;  1BOA A;  5CIK A;  3S6B A;  3L7G A;  2GU5 A;  2B3L A;  4RGZ 1;  3BIT A;  3CB5 A;  5CDL A;  4U70 A;  1WL6 A;  2BWW A;  4IF7 A;  2OKN A;  1YJ3 A;  1YW7 A;  2BWT A;  4RZZ A;  3D27 A;  1YVM A;  2GA2 A;  3MX6 A;  2GU7 A;  1KP0 A;  1KQ9 A;  1R5H A;  2ZSG A;  3TAV A;  1C23 A;  1A16 A;  2BWU A;  3IU7 A;  2GGC A;  2BWS A;  1QXZ A;  1XGO A;  2Q93 A;  4FO7 A;  4IPA A;  2BWX A;  1QXW A;  3PKA A;  4QR8 A;  2ADU A;  3MAT A;  5FCH A;  2MAT A;  1WL9 A;  4KM3 A;  1YW9 A;  4U1B A;  1PV9 A;  1WLR A;  1C22 A;  5D6F A;  2HOW A;  2Q96 A;  1KQ0 A;  1WY2 A;  4U6C A;  2GTX A;  4A6W A;  2GG8 A;  5JHU A;  3TB5 A;  4IKS A;  4ZNG A;  4R60 A;  4IDY A;  2V3Z A;  1C24 A;  2BH3 A;  2NQ7 A;  3FMR A;  2G6P A;  1N51 A;  2BHC A;  2BN7 A;  3BIQ A;  2GZ5 A;  4U6J A;  2GG2 A;  2GU4 A;  4IKU A;  2BHD A;  3PKD A;  1BN5 A;  5CLS A;  1W7V A;  1JAW A;  2EVC A;  3CB6 A;  5JI6 A;  4U75 A;  2B3H A;  4A6V A;  4U6E A;  3L24 A;  4U73 A;  2DFI A;  3PKC A;  2EA2 A;  4ZWU A;  4FLL A;  2BB7 A;  1C27 A;  4S2R P;  2P9A A;  2Q8K A;  1XNZ A;  4FLI A;  3ROR A;  3BIP A;  1XGM A;  2P98 A;  1Y1N A;  1O0X A;  2EVM A;  5D6E A;  1XGN A;  2GG3 A;  4S2T P;  4U6Z A;  1R58 A;  4IEC A;  1C21 A;  3IG4 A;  5FCF A;  1M35 A;  4FLJ A;  4ZWP A;  2OAZ A;  2GG0 A;  4FO8 A;  2BWV A;  5CE6 A;  2GU6 A;  1WN1 A;  1WBQ A;  2EVO A;  2B3K A;  2BWY A;  3IU9 A;  4B28 A;  4PV4 A;  3Q6D A;  2Q95 A;  4U6W A;  2GGB A;  5CDV A;  3IU8 A;  4JUQ A;  3MR1 A;  4ZWO A;  4EGE A;  2V3X A;  4OOK A;  1B6A A;  1YW8 A;  2NQ6 A;  4IKR A;  4FKC A;  4S01 A;  5CDE A;  5JFR A;  4PNC A;  2V6C A;  1CHM A;  4U71 A;  1XGS A;  2IW2 A;  2Q94 A;  2BHA A;  4S00 A;  1QZY A;  3FMQ A;  2P99 A;  2V3Y A;  2GG7 A;  3RVA A;  4IU6 A;  5CNX A;  1R5G A;  2Q92 A; 
#chains in the Genus database with same CATH topology
 4Z7M A;  4HXX A;  2BHB A;  1W2M A;  1WKM A;  1QXY A;  3PKE A;  3CTZ A;  2GG5 A;  2GG9 A;  3FM3 A;  4IKT A;  4MAT A;  4FUK A;  1B59 A;  5E5B A;  4RZY A;  2EA4 A;  4FLK A;  4U76 A;  3PKB A;  4U69 A;  1MAT A;  1BOA A;  5CIK A;  3S6B A;  3L7G A;  2GU5 A;  2B3L A;  4RGZ 1;  3BIT A;  3CB5 A;  5CDL A;  4U70 A;  1WL6 A;  2BWW A;  4IF7 A;  2OKN A;  1YJ3 A;  1YW7 A;  2BWT A;  4RZZ A;  3D27 A;  1YVM A;  2GA2 A;  3MX6 A;  2GU7 A;  1KP0 A;  1KQ9 A;  1R5H A;  2ZSG A;  3TAV A;  1C23 A;  1A16 A;  2BWU A;  3IU7 A;  2GGC A;  2BWS A;  1QXZ A;  1XGO A;  2Q93 A;  4FO7 A;  4IPA A;  2BWX A;  1QXW A;  3PKA A;  4QR8 A;  2ADU A;  3MAT A;  5FCH A;  2MAT A;  1WL9 A;  4KM3 A;  1YW9 A;  4U1B A;  1PV9 A;  1WLR A;  1C22 A;  5D6F A;  2HOW A;  2Q96 A;  1KQ0 A;  1WY2 A;  4U6C A;  2GTX A;  4A6W A;  2GG8 A;  5JHU A;  3TB5 A;  4IKS A;  4ZNG A;  4R60 A;  4IDY A;  2V3Z A;  1C24 A;  2BH3 A;  2NQ7 A;  3FMR A;  2G6P A;  1N51 A;  2BHC A;  2BN7 A;  3BIQ A;  2GZ5 A;  4U6J A;  2GG2 A;  2GU4 A;  4IKU A;  2BHD A;  3PKD A;  1BN5 A;  5CLS A;  1W7V A;  1JAW A;  2EVC A;  3CB6 A;  5JI6 A;  4U75 A;  2B3H A;  4A6V A;  4U6E A;  3L24 A;  4U73 A;  2DFI A;  3PKC A;  2EA2 A;  4ZWU A;  4FLL A;  2BB7 A;  1C27 A;  4S2R P;  2P9A A;  2Q8K A;  1XNZ A;  4FLI A;  3ROR A;  3BIP A;  1XGM A;  2P98 A;  1Y1N A;  1O0X A;  2EVM A;  5D6E A;  1XGN A;  2GG3 A;  4S2T P;  4U6Z A;  1R58 A;  4IEC A;  1C21 A;  3IG4 A;  5FCF A;  1M35 A;  4FLJ A;  4ZWP A;  2OAZ A;  2GG0 A;  4FO8 A;  2BWV A;  5CE6 A;  2GU6 A;  1WN1 A;  1WBQ A;  2EVO A;  2B3K A;  2BWY A;  3IU9 A;  4B28 A;  4PV4 A;  3Q6D A;  2Q95 A;  4U6W A;  2GGB A;  5CDV A;  3IU8 A;  4JUQ A;  3MR1 A;  4ZWO A;  4EGE A;  2V3X A;  4OOK A;  1B6A A;  1YW8 A;  2NQ6 A;  4IKR A;  4FKC A;  4S01 A;  5CDE A;  5JFR A;  4PNC A;  2V6C A;  1CHM A;  4U71 A;  1XGS A;  2IW2 A;  2Q94 A;  2BHA A;  4S00 A;  1QZY A;  3FMQ A;  2P99 A;  2V3Y A;  2GG7 A;  3RVA A;  4IU6 A;  5CNX A;  1R5G A;  2Q92 A; 
#chains in the Genus database with same CATH homology
 4Z7M A;  4HXX A;  2BHB A;  1W2M A;  1WKM A;  1QXY A;  3PKE A;  3CTZ A;  2GG5 A;  2GG9 A;  3FM3 A;  4IKT A;  4MAT A;  4FUK A;  1B59 A;  5E5B A;  4RZY A;  2EA4 A;  4FLK A;  4U76 A;  3PKB A;  4U69 A;  1MAT A;  1BOA A;  5CIK A;  3S6B A;  3L7G A;  2GU5 A;  2B3L A;  4RGZ 1;  3BIT A;  3CB5 A;  5CDL A;  4U70 A;  1WL6 A;  2BWW A;  4IF7 A;  2OKN A;  1YJ3 A;  1YW7 A;  2BWT A;  4RZZ A;  3D27 A;  1YVM A;  2GA2 A;  3MX6 A;  2GU7 A;  1KP0 A;  1KQ9 A;  1R5H A;  2ZSG A;  3TAV A;  1C23 A;  1A16 A;  2BWU A;  3IU7 A;  2GGC A;  2BWS A;  1QXZ A;  1XGO A;  2Q93 A;  4FO7 A;  4IPA A;  2BWX A;  1QXW A;  3PKA A;  4QR8 A;  2ADU A;  3MAT A;  5FCH A;  2MAT A;  1WL9 A;  4KM3 A;  1YW9 A;  4U1B A;  1PV9 A;  1WLR A;  1C22 A;  5D6F A;  2HOW A;  2Q96 A;  1KQ0 A;  1WY2 A;  4U6C A;  2GTX A;  4A6W A;  2GG8 A;  5JHU A;  3TB5 A;  4IKS A;  4ZNG A;  4R60 A;  4IDY A;  2V3Z A;  1C24 A;  2BH3 A;  2NQ7 A;  3FMR A;  2G6P A;  1N51 A;  2BHC A;  2BN7 A;  3BIQ A;  2GZ5 A;  4U6J A;  2GG2 A;  2GU4 A;  4IKU A;  2BHD A;  3PKD A;  1BN5 A;  5CLS A;  1W7V A;  1JAW A;  2EVC A;  3CB6 A;  5JI6 A;  4U75 A;  2B3H A;  4A6V A;  4U6E A;  3L24 A;  4U73 A;  2DFI A;  3PKC A;  2EA2 A;  4ZWU A;  4FLL A;  2BB7 A;  1C27 A;  4S2R P;  2P9A A;  2Q8K A;  1XNZ A;  4FLI A;  3ROR A;  3BIP A;  1XGM A;  2P98 A;  1Y1N A;  1O0X A;  2EVM A;  5D6E A;  1XGN A;  2GG3 A;  4S2T P;  4U6Z A;  1R58 A;  4IEC A;  1C21 A;  3IG4 A;  5FCF A;  1M35 A;  4FLJ A;  4ZWP A;  2OAZ A;  2GG0 A;  4FO8 A;  2BWV A;  5CE6 A;  2GU6 A;  1WN1 A;  1WBQ A;  2EVO A;  2B3K A;  2BWY A;  3IU9 A;  4B28 A;  4PV4 A;  3Q6D A;  2Q95 A;  4U6W A;  2GGB A;  5CDV A;  3IU8 A;  4JUQ A;  3MR1 A;  4ZWO A;  4EGE A;  2V3X A;  4OOK A;  1B6A A;  1YW8 A;  2NQ6 A;  4IKR A;  4FKC A;  4S01 A;  5CDE A;  5JFR A;  4PNC A;  2V6C A;  1CHM A;  4U71 A;  1XGS A;  2IW2 A;  2Q94 A;  2BHA A;  4S00 A;  1QZY A;  3FMQ A;  2P99 A;  2V3Y A;  2GG7 A;  3RVA A;  4IU6 A;  5CNX A;  1R5G A;  2Q92 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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