2GG9A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 86
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg9A00
2B3KA 4ZWPA 1KQ9A 3BIQA 4PV4A 2B3HA 1WL9A 2V3YA 3CB5A 1WY2A 4IKUA 3MR1A 5D6EA 1YJ3A 2GA2A 2BB7A 4IKSA 2GU4A 1R5GA 4IKRA 3PKCA 1YW8A 1KQ0A 1WN1A 4RZYA 3CB6A 4U1BA 1YW9A 1O0XA 1WBQA 4U6WA 3RORA 4B28A 4A6WA 1XGMA 1JAWA 1CHMA 2BWXA 2ZSGA 2NQ6A 3L7GA 3Q6DA 2BHDA 1C21A 4FLKA 4S2TP 2ADUA 4S2RP 5CDEA 4U6ZA 2GG3A 4S01A 2BWTA 1C27A 2BWVA 2GG2A 4IECA 4IF7A 2GG9A 4MATA 4RGZ1 2BH3A 4HXXA 4U6JA 3IU9A 3RVAA 2V6CA 4EGEA 2P99A 4ZWOA 1XGSA 2EA4A 1C23A 3PKBA 2GG5A 2G6PA 1QXWA 4FLIA 2EA2A 2BN7A 3MATA 1QXZA 3PKDA 3TB5A 1XGNA 2Q96A 1W7VA 5JFRA 3BIPA 1R5HA 4FUKA 4RZZA 4U75A 4U76A 2GTXA 2OAZA 2V3ZA 2DFIA 1Y1NA 1YW7A 4PNCA 4A6VA 5CDLA 2OKNA 2GU7A 1QXYA 4FKCA 3TAVA 5JI6A 3IG4A 2IW2A 5D6FA 2BWUA 3FMRA 1KP0A 4JUQA 5E5BA 3IU8A 3FM3A 4KM3A 2BWWA 1XGOA 1BN5A 2B3LA 5CDVA 2GZ5A 3D27A 2Q94A 2V3XA 2BWYA 4IDYA 5CLSA 4FLJA 4U71A 5CIKA 4FLLA 1WL6A 2GGBA 4U6EA 2BHBA 2EVMA 3MX6A 3FMQA 4U6CA 3CTZA 2GU5A 2GU6A 2Q95A 2Q93A 5FCHA 2BWSA 2P9AA 1B59A 5FCFA 1B6AA 5JHUA 2GG0A 3BITA 4ZWUA 1PV9A 2P98A 4FO7A 4IU6A 1R58A 4FO8A 2HOWA 1BOAA 2Q8KA 5CE6A 2GG8A 2Q92A 4R60A 1WLRA 1C24A 3L24A 4IPAA 1WKMA 4IKTA 3S6BA 4U70A 1C22A 2EVOA 4U73A 3PKEA 4Z7MA 4ZNGA 3IU7A 1A16A 1M35A 1MATA 2EVCA 1XNZA 4U69A 1N51A 1W2MA 2GGCA 4S00A 1YVMA 2NQ7A 2MATA 2BHAA 3PKAA 1QZYA 4QR8A 5CNXA 2GG7A 4OOKA 2BHCA
chains in the Genus database with same CATH superfamily
2B3KA 4ZWPA 1KQ9A 3BIQA 4PV4A 2B3HA 1WL9A 2V3YA 3CB5A 1WY2A 4IKUA 3MR1A 5D6EA 1YJ3A 2GA2A 2BB7A 4IKSA 2GU4A 1R5GA 4IKRA 3PKCA 1YW8A 1KQ0A 1WN1A 4RZYA 3CB6A 4U1BA 1YW9A 1O0XA 1WBQA 4U6WA 3RORA 4B28A 4A6WA 1XGMA 1JAWA 1CHMA 2BWXA 2ZSGA 2NQ6A 3L7GA 3Q6DA 2BHDA 1C21A 4FLKA 4S2TP 2ADUA 4S2RP 5CDEA 4U6ZA 2GG3A 4S01A 2BWTA 1C27A 2BWVA 2GG2A 4IECA 4IF7A 2GG9A 4MATA 4RGZ1 2BH3A 4HXXA 4U6JA 3IU9A 3RVAA 2V6CA 4EGEA 2P99A 4ZWOA 1XGSA 2EA4A 1C23A 3PKBA 2GG5A 2G6PA 1QXWA 4FLIA 2EA2A 2BN7A 3MATA 1QXZA 3PKDA 3TB5A 1XGNA 2Q96A 1W7VA 5JFRA 3BIPA 1R5HA 4FUKA 4RZZA 4U75A 4U76A 2GTXA 2OAZA 2V3ZA 2DFIA 1Y1NA 1YW7A 4PNCA 4A6VA 5CDLA 2OKNA 2GU7A 1QXYA 4FKCA 3TAVA 5JI6A 3IG4A 2IW2A 5D6FA 2BWUA 3FMRA 1KP0A 4JUQA 5E5BA 3IU8A 3FM3A 4KM3A 2BWWA 1XGOA 1BN5A 2B3LA 5CDVA 2GZ5A 3D27A 2Q94A 2V3XA 2BWYA 4IDYA 5CLSA 4FLJA 4U71A 5CIKA 4FLLA 1WL6A 2GGBA 4U6EA 2BHBA 2EVMA 3MX6A 3FMQA 4U6CA 3CTZA 2GU5A 2GU6A 2Q95A 2Q93A 5FCHA 2BWSA 2P9AA 1B59A 5FCFA 1B6AA 5JHUA 2GG0A 3BITA 4ZWUA 1PV9A 2P98A 4FO7A 4IU6A 1R58A 4FO8A 2HOWA 1BOAA 2Q8KA 5CE6A 2GG8A 2Q92A 4R60A 1WLRA 1C24A 3L24A 4IPAA 1WKMA 4IKTA 3S6BA 4U70A 1C22A 2EVOA 4U73A 3PKEA 4Z7MA 4ZNGA 3IU7A 1A16A 1M35A 1MATA 2EVCA 1XNZA 4U69A 1N51A 1W2MA 2GGCA 4S00A 1YVMA 2NQ7A 2MATA 2BHAA 3PKAA 1QZYA 4QR8A 5CNXA 2GG7A 4OOKA 2BHCA
chains in the Genus database with same CATH topology
2B3KA 4ZWPA 1KQ9A 3BIQA 4PV4A 2B3HA 1WL9A 2V3YA 3CB5A 1WY2A 4IKUA 3MR1A 5D6EA 1YJ3A 2GA2A 2BB7A 4IKSA 2GU4A 1R5GA 4IKRA 3PKCA 1YW8A 1KQ0A 1WN1A 4RZYA 3CB6A 4U1BA 1YW9A 1O0XA 1WBQA 4U6WA 3RORA 4B28A 4A6WA 1XGMA 1JAWA 1CHMA 2BWXA 2ZSGA 2NQ6A 3L7GA 3Q6DA 2BHDA 1C21A 4FLKA 4S2TP 2ADUA 4S2RP 5CDEA 4U6ZA 2GG3A 4S01A 2BWTA 1C27A 2BWVA 2GG2A 4IECA 4IF7A 2GG9A 4MATA 4RGZ1 2BH3A 4HXXA 4U6JA 3IU9A 3RVAA 2V6CA 4EGEA 2P99A 4ZWOA 1XGSA 2EA4A 1C23A 3PKBA 2GG5A 2G6PA 1QXWA 4FLIA 2EA2A 2BN7A 3MATA 1QXZA 3PKDA 3TB5A 1XGNA 2Q96A 1W7VA 5JFRA 3BIPA 1R5HA 4FUKA 4RZZA 4U75A 4U76A 2GTXA 2OAZA 2V3ZA 2DFIA 1Y1NA 1YW7A 4PNCA 4A6VA 5CDLA 2OKNA 2GU7A 1QXYA 4FKCA 3TAVA 5JI6A 3IG4A 2IW2A 5D6FA 2BWUA 3FMRA 1KP0A 4JUQA 5E5BA 3IU8A 3FM3A 4KM3A 2BWWA 1XGOA 1BN5A 2B3LA 5CDVA 2GZ5A 3D27A 2Q94A 2V3XA 2BWYA 4IDYA 5CLSA 4FLJA 4U71A 5CIKA 4FLLA 1WL6A 2GGBA 4U6EA 2BHBA 2EVMA 3MX6A 3FMQA 4U6CA 3CTZA 2GU5A 2GU6A 2Q95A 2Q93A 5FCHA 2BWSA 2P9AA 1B59A 5FCFA 1B6AA 5JHUA 2GG0A 3BITA 4ZWUA 1PV9A 2P98A 4FO7A 4IU6A 1R58A 4FO8A 2HOWA 1BOAA 2Q8KA 5CE6A 2GG8A 2Q92A 4R60A 1WLRA 1C24A 3L24A 4IPAA 1WKMA 4IKTA 3S6BA 4U70A 1C22A 2EVOA 4U73A 3PKEA 4Z7MA 4ZNGA 3IU7A 1A16A 1M35A 1MATA 2EVCA 1XNZA 4U69A 1N51A 1W2MA 2GGCA 4S00A 1YVMA 2NQ7A 2MATA 2BHAA 3PKAA 1QZYA 4QR8A 5CNXA 2GG7A 4OOKA 2BHCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B3K A;  4ZWP A;  1KQ9 A;  3BIQ A;  4PV4 A;  2B3H A;  1WL9 A;  2V3Y A;  3CB5 A;  1WY2 A;  4IKU A;  3MR1 A;  5D6E A;  1YJ3 A;  2GA2 A;  2BB7 A;  4IKS A;  2GU4 A;  1R5G A;  4IKR A;  3PKC A;  1YW8 A;  1KQ0 A;  1WN1 A;  4RZY A;  3CB6 A;  4U1B A;  1YW9 A;  1O0X A;  1WBQ A;  4U6W A;  3ROR A;  4B28 A;  4A6W A;  1XGM A;  1JAW A;  1CHM A;  2BWX A;  2ZSG A;  2NQ6 A;  3L7G A;  3Q6D A;  2BHD A;  1C21 A;  4FLK A;  4S2T P;  2ADU A;  4S2R P;  5CDE A;  4U6Z A;  2GG3 A;  4S01 A;  2BWT A;  1C27 A;  2BWV A;  2GG2 A;  4IEC A;  4IF7 A;  2GG9 A;  4MAT A;  4RGZ 1;  2BH3 A;  4HXX A;  4U6J A;  3IU9 A;  3RVA A;  2V6C A;  4EGE A;  2P99 A;  4ZWO A;  1XGS A;  2EA4 A;  1C23 A;  3PKB A;  2GG5 A;  2G6P A;  1QXW A;  4FLI A;  2EA2 A;  2BN7 A;  3MAT A;  1QXZ A;  3PKD A;  3TB5 A;  1XGN A;  2Q96 A;  1W7V A;  5JFR A;  3BIP A;  1R5H A;  4FUK A;  4RZZ A;  4U75 A;  4U76 A;  2GTX A;  2OAZ A;  2V3Z A;  2DFI A;  1Y1N A;  1YW7 A;  4PNC A;  4A6V A;  5CDL A;  2OKN A;  2GU7 A;  1QXY A;  4FKC A;  3TAV A;  5JI6 A;  3IG4 A;  2IW2 A;  5D6F A;  2BWU A;  3FMR A;  1KP0 A;  4JUQ A;  5E5B A;  3IU8 A;  3FM3 A;  4KM3 A;  2BWW A;  1XGO A;  1BN5 A;  2B3L A;  5CDV A;  2GZ5 A;  3D27 A;  2Q94 A;  2V3X A;  2BWY A;  4IDY A;  5CLS A;  4FLJ A;  4U71 A;  5CIK A;  4FLL A;  1WL6 A;  2GGB A;  4U6E A;  2BHB A;  2EVM A;  3MX6 A;  3FMQ A;  4U6C A;  3CTZ A;  2GU5 A;  2GU6 A;  2Q95 A;  2Q93 A;  5FCH A;  2BWS A;  2P9A A;  1B59 A;  5FCF A;  1B6A A;  5JHU A;  2GG0 A;  3BIT A;  4ZWU A;  1PV9 A;  2P98 A;  4FO7 A;  4IU6 A;  1R58 A;  4FO8 A;  2HOW A;  1BOA A;  2Q8K A;  5CE6 A;  2GG8 A;  2Q92 A;  4R60 A;  1WLR A;  1C24 A;  3L24 A;  4IPA A;  1WKM A;  4IKT A;  3S6B A;  4U70 A;  1C22 A;  2EVO A;  4U73 A;  3PKE A;  4Z7M A;  4ZNG A;  3IU7 A;  1A16 A;  1M35 A;  1MAT A;  2EVC A;  1XNZ A;  4U69 A;  1N51 A;  1W2M A;  2GGC A;  4S00 A;  1YVM A;  2NQ7 A;  2MAT A;  2BHA A;  3PKA A;  1QZY A;  4QR8 A;  5CNX A;  2GG7 A;  4OOK A;  2BHC A; 
#chains in the Genus database with same CATH topology
 2B3K A;  4ZWP A;  1KQ9 A;  3BIQ A;  4PV4 A;  2B3H A;  1WL9 A;  2V3Y A;  3CB5 A;  1WY2 A;  4IKU A;  3MR1 A;  5D6E A;  1YJ3 A;  2GA2 A;  2BB7 A;  4IKS A;  2GU4 A;  1R5G A;  4IKR A;  3PKC A;  1YW8 A;  1KQ0 A;  1WN1 A;  4RZY A;  3CB6 A;  4U1B A;  1YW9 A;  1O0X A;  1WBQ A;  4U6W A;  3ROR A;  4B28 A;  4A6W A;  1XGM A;  1JAW A;  1CHM A;  2BWX A;  2ZSG A;  2NQ6 A;  3L7G A;  3Q6D A;  2BHD A;  1C21 A;  4FLK A;  4S2T P;  2ADU A;  4S2R P;  5CDE A;  4U6Z A;  2GG3 A;  4S01 A;  2BWT A;  1C27 A;  2BWV A;  2GG2 A;  4IEC A;  4IF7 A;  2GG9 A;  4MAT A;  4RGZ 1;  2BH3 A;  4HXX A;  4U6J A;  3IU9 A;  3RVA A;  2V6C A;  4EGE A;  2P99 A;  4ZWO A;  1XGS A;  2EA4 A;  1C23 A;  3PKB A;  2GG5 A;  2G6P A;  1QXW A;  4FLI A;  2EA2 A;  2BN7 A;  3MAT A;  1QXZ A;  3PKD A;  3TB5 A;  1XGN A;  2Q96 A;  1W7V A;  5JFR A;  3BIP A;  1R5H A;  4FUK A;  4RZZ A;  4U75 A;  4U76 A;  2GTX A;  2OAZ A;  2V3Z A;  2DFI A;  1Y1N A;  1YW7 A;  4PNC A;  4A6V A;  5CDL A;  2OKN A;  2GU7 A;  1QXY A;  4FKC A;  3TAV A;  5JI6 A;  3IG4 A;  2IW2 A;  5D6F A;  2BWU A;  3FMR A;  1KP0 A;  4JUQ A;  5E5B A;  3IU8 A;  3FM3 A;  4KM3 A;  2BWW A;  1XGO A;  1BN5 A;  2B3L A;  5CDV A;  2GZ5 A;  3D27 A;  2Q94 A;  2V3X A;  2BWY A;  4IDY A;  5CLS A;  4FLJ A;  4U71 A;  5CIK A;  4FLL A;  1WL6 A;  2GGB A;  4U6E A;  2BHB A;  2EVM A;  3MX6 A;  3FMQ A;  4U6C A;  3CTZ A;  2GU5 A;  2GU6 A;  2Q95 A;  2Q93 A;  5FCH A;  2BWS A;  2P9A A;  1B59 A;  5FCF A;  1B6A A;  5JHU A;  2GG0 A;  3BIT A;  4ZWU A;  1PV9 A;  2P98 A;  4FO7 A;  4IU6 A;  1R58 A;  4FO8 A;  2HOW A;  1BOA A;  2Q8K A;  5CE6 A;  2GG8 A;  2Q92 A;  4R60 A;  1WLR A;  1C24 A;  3L24 A;  4IPA A;  1WKM A;  4IKT A;  3S6B A;  4U70 A;  1C22 A;  2EVO A;  4U73 A;  3PKE A;  4Z7M A;  4ZNG A;  3IU7 A;  1A16 A;  1M35 A;  1MAT A;  2EVC A;  1XNZ A;  4U69 A;  1N51 A;  1W2M A;  2GGC A;  4S00 A;  1YVM A;  2NQ7 A;  2MAT A;  2BHA A;  3PKA A;  1QZY A;  4QR8 A;  5CNX A;  2GG7 A;  4OOK A;  2BHC A; 
#chains in the Genus database with same CATH homology
 2B3K A;  4ZWP A;  1KQ9 A;  3BIQ A;  4PV4 A;  2B3H A;  1WL9 A;  2V3Y A;  3CB5 A;  1WY2 A;  4IKU A;  3MR1 A;  5D6E A;  1YJ3 A;  2GA2 A;  2BB7 A;  4IKS A;  2GU4 A;  1R5G A;  4IKR A;  3PKC A;  1YW8 A;  1KQ0 A;  1WN1 A;  4RZY A;  3CB6 A;  4U1B A;  1YW9 A;  1O0X A;  1WBQ A;  4U6W A;  3ROR A;  4B28 A;  4A6W A;  1XGM A;  1JAW A;  1CHM A;  2BWX A;  2ZSG A;  2NQ6 A;  3L7G A;  3Q6D A;  2BHD A;  1C21 A;  4FLK A;  4S2T P;  2ADU A;  4S2R P;  5CDE A;  4U6Z A;  2GG3 A;  4S01 A;  2BWT A;  1C27 A;  2BWV A;  2GG2 A;  4IEC A;  4IF7 A;  2GG9 A;  4MAT A;  4RGZ 1;  2BH3 A;  4HXX A;  4U6J A;  3IU9 A;  3RVA A;  2V6C A;  4EGE A;  2P99 A;  4ZWO A;  1XGS A;  2EA4 A;  1C23 A;  3PKB A;  2GG5 A;  2G6P A;  1QXW A;  4FLI A;  2EA2 A;  2BN7 A;  3MAT A;  1QXZ A;  3PKD A;  3TB5 A;  1XGN A;  2Q96 A;  1W7V A;  5JFR A;  3BIP A;  1R5H A;  4FUK A;  4RZZ A;  4U75 A;  4U76 A;  2GTX A;  2OAZ A;  2V3Z A;  2DFI A;  1Y1N A;  1YW7 A;  4PNC A;  4A6V A;  5CDL A;  2OKN A;  2GU7 A;  1QXY A;  4FKC A;  3TAV A;  5JI6 A;  3IG4 A;  2IW2 A;  5D6F A;  2BWU A;  3FMR A;  1KP0 A;  4JUQ A;  5E5B A;  3IU8 A;  3FM3 A;  4KM3 A;  2BWW A;  1XGO A;  1BN5 A;  2B3L A;  5CDV A;  2GZ5 A;  3D27 A;  2Q94 A;  2V3X A;  2BWY A;  4IDY A;  5CLS A;  4FLJ A;  4U71 A;  5CIK A;  4FLL A;  1WL6 A;  2GGB A;  4U6E A;  2BHB A;  2EVM A;  3MX6 A;  3FMQ A;  4U6C A;  3CTZ A;  2GU5 A;  2GU6 A;  2Q95 A;  2Q93 A;  5FCH A;  2BWS A;  2P9A A;  1B59 A;  5FCF A;  1B6A A;  5JHU A;  2GG0 A;  3BIT A;  4ZWU A;  1PV9 A;  2P98 A;  4FO7 A;  4IU6 A;  1R58 A;  4FO8 A;  2HOW A;  1BOA A;  2Q8K A;  5CE6 A;  2GG8 A;  2Q92 A;  4R60 A;  1WLR A;  1C24 A;  3L24 A;  4IPA A;  1WKM A;  4IKT A;  3S6B A;  4U70 A;  1C22 A;  2EVO A;  4U73 A;  3PKE A;  4Z7M A;  4ZNG A;  3IU7 A;  1A16 A;  1M35 A;  1MAT A;  2EVC A;  1XNZ A;  4U69 A;  1N51 A;  1W2M A;  2GGC A;  4S00 A;  1YVM A;  2NQ7 A;  2MAT A;  2BHA A;  3PKA A;  1QZY A;  4QR8 A;  5CNX A;  2GG7 A;  4OOK A;  2BHC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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