2GLQA

X-ray structure of human alkaline phosphatase in complex with strontium
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
478
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 172
structure length 478
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2glqA00
1ZEFA 1SHQA 2W5TA 4LRBA 4N7TA 3NKOA 3TWZA 4GTZA 3KD8A 1O99A 4KAYA 4MIVA 4ZGAA 1SHNA 1EW8A 4KJGA 3LXQA 2ANHA 4UPHA 4CYSA 1ELXA 1ALIA 1AJCA 3MK0A 3TX0A 5AJ9A 2IUCA 4NWJA 1AJDA 1KHKA 3WBHA 4ZG7A 4B56A 1HQAA 1B8JA 1ELYA 3CMRA 3WAYA 4LRDA 4KM4A 2GSOA 3TG0A 5LIAA 1Y7AA 3MK1A 1N2KA 3UN5A 4CXSA 4QAXA 2VQRA 4UPIA 1O98A 1E2SP 5TJ3A 2GSNA 3NKMA 1ANIA 1P49A 3NKRA 4LRAA 3M8YA 4KAVA 5IJSA 3T02A 3M7VA 3NKQA 1K7HA 3M8WA 4GTYA 2W5QA 5GOVA 3MK2A 1KH5A 4FDJA 1ANJA 3B5QA 3UN3A 2IFYA 5DLWA 1ALKA 3WAVA 3WAWA 4ZG9A 4LR7A 4UORA 1EW2A 1HDHA 1ZEBA 1URAA 2GSUA 2IUCB 2W5XA 3A52A 3BDGA 3NKPA 5K4PA 3T01A 3UNYA 4GTWA 4CYRA 4LR9A 1HJKA 2G9YA 4YR1A 2W5WA 1ALJA 3IDDA 1E1ZP 5LQQA 5C66A 2GLQA 2W5VA 1EJJA 4UOPA 5L0EA 3DPCA 5DLTA 1KH7A 1KH4A 3IGZB 1URBA 2XRGA 3Q3QA 2D1GA 1EW9A 4LRFA 1ED8A 1Y6VA 2W5RA 4MY4A 1ELZA 4LREA 3NKNA 1EI6A 3DYCA 5L0BA 5HRTA 3SZYA 5L0KA 1FSUA 4GTXA 4LRCA 4ZG6A 1E33P 3BDFA 3M8ZA 3T00A 4TN0A 4CXUA 3BDGB 5DLVA 1KH9A 3UO0A 3OT9A 3WAXA 4UPLA 3IGYB 4LR8A 1EQJA 1ED9A 4LR2A 4UOOA 2W8DA 4LQYA 2XR9A 2QZUA 1AJBA 1ALHA 2ZKTA 1KHJA 2X98A 3SZZA 1ZEDA 4KJDA 3ED4A 3UN2A 5INHA 5KXAA 1E3CP 4NWXA 5EGHA 2W8SA 5GRRA 1AJAA 5IJQA 1KHLA 1N2LA 4FDIA 2W5SA 5EGEA 2GA3A 4MHXA 5LRNA 3BDHA 3E2DA 5LRMA 2RH6A 4CXKA 1KHNA 4UPKA 1AUKA 3NVLA
chains in the Genus database with same CATH superfamily
1ZEFA 1SHQA 2W5TA 4LRBA 4N7TA 3NKOA 3TWZA 4GTZA 3KD8A 1O99A 4KAYA 4MIVA 4ZGAA 1SHNA 1EW8A 4KJGA 3LXQA 2ANHA 4UPHA 4CYSA 1ELXA 1ALIA 1AJCA 3MK0A 3TX0A 5AJ9A 2IUCA 4NWJA 1AJDA 1KHKA 3WBHA 4ZG7A 4B56A 1HQAA 1B8JA 1ELYA 3CMRA 3WAYA 4LRDA 4KM4A 2GSOA 3TG0A 5LIAA 1Y7AA 3MK1A 1N2KA 3UN5A 4CXSA 4QAXA 2VQRA 4UPIA 1O98A 1E2SP 5TJ3A 2GSNA 3NKMA 1ANIA 1P49A 3NKRA 4LRAA 3M8YA 4KAVA 5IJSA 3T02A 3M7VA 3NKQA 1K7HA 3M8WA 4GTYA 2W5QA 5GOVA 3MK2A 1KH5A 4FDJA 1ANJA 3B5QA 3UN3A 2IFYA 5DLWA 1ALKA 3WAVA 3WAWA 4ZG9A 4LR7A 4UORA 1EW2A 1HDHA 1ZEBA 1URAA 2GSUA 2IUCB 2W5XA 3A52A 3BDGA 3NKPA 5K4PA 3T01A 3UNYA 4GTWA 4CYRA 4LR9A 1HJKA 2G9YA 4YR1A 2W5WA 1ALJA 3IDDA 1E1ZP 5LQQA 5C66A 2GLQA 2W5VA 1EJJA 4UOPA 5L0EA 3DPCA 5DLTA 1KH7A 1KH4A 3IGZB 1URBA 2XRGA 3Q3QA 2D1GA 1EW9A 4LRFA 1ED8A 1Y6VA 2W5RA 4MY4A 1ELZA 4LREA 3NKNA 1EI6A 3DYCA 5L0BA 5HRTA 3SZYA 5L0KA 1FSUA 4GTXA 4LRCA 4ZG6A 1E33P 3BDFA 3M8ZA 3T00A 4TN0A 4CXUA 3BDGB 5DLVA 1KH9A 3UO0A 3OT9A 3WAXA 4UPLA 3IGYB 4LR8A 1EQJA 1ED9A 4LR2A 4UOOA 2W8DA 4LQYA 2XR9A 2QZUA 1AJBA 1ALHA 2ZKTA 1KHJA 2X98A 3SZZA 1ZEDA 4KJDA 3ED4A 3UN2A 5INHA 5KXAA 1E3CP 4NWXA 5EGHA 2W8SA 5GRRA 1AJAA 5IJQA 1KHLA 1N2LA 4FDIA 2W5SA 5EGEA 2GA3A 4MHXA 5LRNA 3BDHA 3E2DA 5LRMA 2RH6A 4CXKA 1KHNA 4UPKA 1AUKA 3NVLA
chains in the Genus database with same CATH topology
1ZEFA 1SHQA 2W5TA 4LRBA 4N7TA 3NKOA 3TWZA 4GTZA 3KD8A 1O99A 4KAYA 4MIVA 4ZGAA 1SHNA 1EW8A 4KJGA 3LXQA 2ANHA 4UPHA 4CYSA 1ELXA 1ALIA 1AJCA 3MK0A 3TX0A 5AJ9A 2IUCA 4NWJA 1AJDA 1KHKA 3WBHA 4ZG7A 4B56A 1HQAA 1B8JA 1ELYA 3CMRA 3WAYA 4LRDA 4KM4A 2GSOA 3TG0A 5LIAA 1Y7AA 3MK1A 1N2KA 3UN5A 4CXSA 4QAXA 2VQRA 4UPIA 1O98A 1E2SP 5TJ3A 2GSNA 3NKMA 1ANIA 1P49A 3NKRA 4LRAA 3M8YA 4KAVA 5IJSA 3T02A 3M7VA 3NKQA 1K7HA 3M8WA 4GTYA 2W5QA 5GOVA 3MK2A 1KH5A 4FDJA 1ANJA 3B5QA 3UN3A 2IFYA 5DLWA 1ALKA 3WAVA 3WAWA 4ZG9A 4LR7A 4UORA 1EW2A 1HDHA 1ZEBA 1URAA 2GSUA 2IUCB 2W5XA 3A52A 3BDGA 3NKPA 5K4PA 3T01A 3UNYA 4GTWA 4CYRA 4LR9A 1HJKA 2G9YA 4YR1A 2W5WA 1ALJA 3IDDA 1E1ZP 5LQQA 5C66A 2GLQA 2W5VA 1EJJA 4UOPA 5L0EA 3DPCA 5DLTA 1KH7A 1KH4A 3IGZB 1URBA 2XRGA 3Q3QA 2D1GA 1EW9A 4LRFA 1ED8A 1Y6VA 2W5RA 4MY4A 1ELZA 4LREA 3NKNA 1EI6A 3DYCA 5L0BA 5HRTA 3SZYA 5L0KA 1FSUA 4GTXA 4LRCA 4ZG6A 1E33P 3BDFA 3M8ZA 3T00A 4TN0A 4CXUA 3BDGB 5DLVA 1KH9A 3UO0A 3OT9A 3WAXA 4UPLA 3IGYB 4LR8A 1EQJA 1ED9A 4LR2A 4UOOA 2W8DA 4LQYA 2XR9A 2QZUA 1AJBA 1ALHA 2ZKTA 1KHJA 2X98A 3SZZA 1ZEDA 4KJDA 3ED4A 3UN2A 5INHA 5KXAA 1E3CP 4NWXA 5EGHA 2W8SA 5GRRA 1AJAA 5IJQA 1KHLA 1N2LA 4FDIA 2W5SA 5EGEA 2GA3A 4MHXA 5LRNA 3BDHA 3E2DA 5LRMA 2RH6A 4CXKA 1KHNA 4UPKA 1AUKA 3NVLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZEF A;  1SHQ A;  2W5T A;  4LRB A;  4N7T A;  3NKO A;  3TWZ A;  4GTZ A;  3KD8 A;  1O99 A;  4KAY A;  4MIV A;  4ZGA A;  1SHN A;  1EW8 A;  4KJG A;  3LXQ A;  2ANH A;  4UPH A;  4CYS A;  1ELX A;  1ALI A;  1AJC A;  3MK0 A;  3TX0 A;  5AJ9 A;  2IUC A;  4NWJ A;  1AJD A;  1KHK A;  3WBH A;  4ZG7 A;  4B56 A;  1HQA A;  1B8J A;  1ELY A;  3CMR A;  3WAY A;  4LRD A;  4KM4 A;  2GSO A;  3TG0 A;  5LIA A;  1Y7A A;  3MK1 A;  1N2K A;  3UN5 A;  4CXS A;  4QAX A;  2VQR A;  4UPI A;  1O98 A;  1E2S P;  5TJ3 A;  2GSN A;  3NKM A;  1ANI A;  1P49 A;  3NKR A;  4LRA A;  3M8Y A;  4KAV A;  5IJS A;  3T02 A;  3M7V A;  3NKQ A;  1K7H A;  3M8W A;  4GTY A;  2W5Q A;  5GOV A;  3MK2 A;  1KH5 A;  4FDJ A;  1ANJ A;  3B5Q A;  3UN3 A;  2IFY A;  5DLW A;  1ALK A;  3WAV A;  3WAW A;  4ZG9 A;  4LR7 A;  4UOR A;  1EW2 A;  1HDH A;  1ZEB A;  1URA A;  2GSU A;  2IUC B;  2W5X A;  3A52 A;  3BDG A;  3NKP A;  5K4P A;  3T01 A;  3UNY A;  4GTW A;  4CYR A;  4LR9 A;  1HJK A;  2G9Y A;  4YR1 A;  2W5W A;  1ALJ A;  3IDD A;  1E1Z P;  5LQQ A;  5C66 A;  2GLQ A;  2W5V A;  1EJJ A;  4UOP A;  5L0E A;  3DPC A;  5DLT A;  1KH7 A;  1KH4 A;  3IGZ B;  1URB A;  2XRG A;  3Q3Q A;  2D1G A;  1EW9 A;  4LRF A;  1ED8 A;  1Y6V A;  2W5R A;  4MY4 A;  1ELZ A;  4LRE A;  3NKN A;  1EI6 A;  3DYC A;  5L0B A;  5HRT A;  3SZY A;  5L0K A;  1FSU A;  4GTX A;  4LRC A;  4ZG6 A;  1E33 P;  3BDF A;  3M8Z A;  3T00 A;  4TN0 A;  4CXU A;  3BDG B;  5DLV A;  1KH9 A;  3UO0 A;  3OT9 A;  3WAX A;  4UPL A;  3IGY B;  4LR8 A;  1EQJ A;  1ED9 A;  4LR2 A;  4UOO A;  2W8D A;  4LQY A;  2XR9 A;  2QZU A;  1AJB A;  1ALH A;  2ZKT A;  1KHJ A;  2X98 A;  3SZZ A;  1ZED A;  4KJD A;  3ED4 A;  3UN2 A;  5INH A;  5KXA A;  1E3C P;  4NWX A;  5EGH A;  2W8S A;  5GRR A;  1AJA A;  5IJQ A;  1KHL A;  1N2L A;  4FDI A;  2W5S A;  5EGE A;  2GA3 A;  4MHX A;  5LRN A;  3BDH A;  3E2D A;  5LRM A;  2RH6 A;  4CXK A;  1KHN A;  4UPK A;  1AUK A;  3NVL A; 
#chains in the Genus database with same CATH topology
 1ZEF A;  1SHQ A;  2W5T A;  4LRB A;  4N7T A;  3NKO A;  3TWZ A;  4GTZ A;  3KD8 A;  1O99 A;  4KAY A;  4MIV A;  4ZGA A;  1SHN A;  1EW8 A;  4KJG A;  3LXQ A;  2ANH A;  4UPH A;  4CYS A;  1ELX A;  1ALI A;  1AJC A;  3MK0 A;  3TX0 A;  5AJ9 A;  2IUC A;  4NWJ A;  1AJD A;  1KHK A;  3WBH A;  4ZG7 A;  4B56 A;  1HQA A;  1B8J A;  1ELY A;  3CMR A;  3WAY A;  4LRD A;  4KM4 A;  2GSO A;  3TG0 A;  5LIA A;  1Y7A A;  3MK1 A;  1N2K A;  3UN5 A;  4CXS A;  4QAX A;  2VQR A;  4UPI A;  1O98 A;  1E2S P;  5TJ3 A;  2GSN A;  3NKM A;  1ANI A;  1P49 A;  3NKR A;  4LRA A;  3M8Y A;  4KAV A;  5IJS A;  3T02 A;  3M7V A;  3NKQ A;  1K7H A;  3M8W A;  4GTY A;  2W5Q A;  5GOV A;  3MK2 A;  1KH5 A;  4FDJ A;  1ANJ A;  3B5Q A;  3UN3 A;  2IFY A;  5DLW A;  1ALK A;  3WAV A;  3WAW A;  4ZG9 A;  4LR7 A;  4UOR A;  1EW2 A;  1HDH A;  1ZEB A;  1URA A;  2GSU A;  2IUC B;  2W5X A;  3A52 A;  3BDG A;  3NKP A;  5K4P A;  3T01 A;  3UNY A;  4GTW A;  4CYR A;  4LR9 A;  1HJK A;  2G9Y A;  4YR1 A;  2W5W A;  1ALJ A;  3IDD A;  1E1Z P;  5LQQ A;  5C66 A;  2GLQ A;  2W5V A;  1EJJ A;  4UOP A;  5L0E A;  3DPC A;  5DLT A;  1KH7 A;  1KH4 A;  3IGZ B;  1URB A;  2XRG A;  3Q3Q A;  2D1G A;  1EW9 A;  4LRF A;  1ED8 A;  1Y6V A;  2W5R A;  4MY4 A;  1ELZ A;  4LRE A;  3NKN A;  1EI6 A;  3DYC A;  5L0B A;  5HRT A;  3SZY A;  5L0K A;  1FSU A;  4GTX A;  4LRC A;  4ZG6 A;  1E33 P;  3BDF A;  3M8Z A;  3T00 A;  4TN0 A;  4CXU A;  3BDG B;  5DLV A;  1KH9 A;  3UO0 A;  3OT9 A;  3WAX A;  4UPL A;  3IGY B;  4LR8 A;  1EQJ A;  1ED9 A;  4LR2 A;  4UOO A;  2W8D A;  4LQY A;  2XR9 A;  2QZU A;  1AJB A;  1ALH A;  2ZKT A;  1KHJ A;  2X98 A;  3SZZ A;  1ZED A;  4KJD A;  3ED4 A;  3UN2 A;  5INH A;  5KXA A;  1E3C P;  4NWX A;  5EGH A;  2W8S A;  5GRR A;  1AJA A;  5IJQ A;  1KHL A;  1N2L A;  4FDI A;  2W5S A;  5EGE A;  2GA3 A;  4MHX A;  5LRN A;  3BDH A;  3E2D A;  5LRM A;  2RH6 A;  4CXK A;  1KHN A;  4UPK A;  1AUK A;  3NVL A; 
#chains in the Genus database with same CATH homology
 1ZEF A;  1SHQ A;  2W5T A;  4LRB A;  4N7T A;  3NKO A;  3TWZ A;  4GTZ A;  3KD8 A;  1O99 A;  4KAY A;  4MIV A;  4ZGA A;  1SHN A;  1EW8 A;  4KJG A;  3LXQ A;  2ANH A;  4UPH A;  4CYS A;  1ELX A;  1ALI A;  1AJC A;  3MK0 A;  3TX0 A;  5AJ9 A;  2IUC A;  4NWJ A;  1AJD A;  1KHK A;  3WBH A;  4ZG7 A;  4B56 A;  1HQA A;  1B8J A;  1ELY A;  3CMR A;  3WAY A;  4LRD A;  4KM4 A;  2GSO A;  3TG0 A;  5LIA A;  1Y7A A;  3MK1 A;  1N2K A;  3UN5 A;  4CXS A;  4QAX A;  2VQR A;  4UPI A;  1O98 A;  1E2S P;  5TJ3 A;  2GSN A;  3NKM A;  1ANI A;  1P49 A;  3NKR A;  4LRA A;  3M8Y A;  4KAV A;  5IJS A;  3T02 A;  3M7V A;  3NKQ A;  1K7H A;  3M8W A;  4GTY A;  2W5Q A;  5GOV A;  3MK2 A;  1KH5 A;  4FDJ A;  1ANJ A;  3B5Q A;  3UN3 A;  2IFY A;  5DLW A;  1ALK A;  3WAV A;  3WAW A;  4ZG9 A;  4LR7 A;  4UOR A;  1EW2 A;  1HDH A;  1ZEB A;  1URA A;  2GSU A;  2IUC B;  2W5X A;  3A52 A;  3BDG A;  3NKP A;  5K4P A;  3T01 A;  3UNY A;  4GTW A;  4CYR A;  4LR9 A;  1HJK A;  2G9Y A;  4YR1 A;  2W5W A;  1ALJ A;  3IDD A;  1E1Z P;  5LQQ A;  5C66 A;  2GLQ A;  2W5V A;  1EJJ A;  4UOP A;  5L0E A;  3DPC A;  5DLT A;  1KH7 A;  1KH4 A;  3IGZ B;  1URB A;  2XRG A;  3Q3Q A;  2D1G A;  1EW9 A;  4LRF A;  1ED8 A;  1Y6V A;  2W5R A;  4MY4 A;  1ELZ A;  4LRE A;  3NKN A;  1EI6 A;  3DYC A;  5L0B A;  5HRT A;  3SZY A;  5L0K A;  1FSU A;  4GTX A;  4LRC A;  4ZG6 A;  1E33 P;  3BDF A;  3M8Z A;  3T00 A;  4TN0 A;  4CXU A;  3BDG B;  5DLV A;  1KH9 A;  3UO0 A;  3OT9 A;  3WAX A;  4UPL A;  3IGY B;  4LR8 A;  1EQJ A;  1ED9 A;  4LR2 A;  4UOO A;  2W8D A;  4LQY A;  2XR9 A;  2QZU A;  1AJB A;  1ALH A;  2ZKT A;  1KHJ A;  2X98 A;  3SZZ A;  1ZED A;  4KJD A;  3ED4 A;  3UN2 A;  5INH A;  5KXA A;  1E3C P;  4NWX A;  5EGH A;  2W8S A;  5GRR A;  1AJA A;  5IJQ A;  1KHL A;  1N2L A;  4FDI A;  2W5S A;  5EGE A;  2GA3 A;  4MHX A;  5LRN A;  3BDH A;  3E2D A;  5LRM A;  2RH6 A;  4CXK A;  1KHN A;  4UPK A;  1AUK A;  3NVL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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