2P98A

E. coli methionine aminopeptidase monometalated with inhibitor ye7
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p98A00
2OKNA 1R5GA 3IU7A 1M35A 5CDLA 2V3ZA 4PNCA 2GU6A 1Y1NA 1B59A 2BHCA 1YW9A 2GG3A 1XGMA 3MATA 4FLIA 2BN7A 5D6EA 2NQ6A 1C24A 1PV9A 1W7VA 3PKEA 3TB5A 2V3XA 5CNXA 4RGZ1 1XGNA 4ZWUA 2BHAA 1WL9A 1C27A 3PKAA 1QXYA 1YW7A 1YJ3A 3CB5A 3PKBA 3IG4A 3PKDA 1R58A 2GGCA 5JI6A 1C22A 1WL6A 2GU5A 2P99A 4JUQA 4FLKA 2BWVA 3RORA 4OOKA 4IECA 2EVOA 4U70A 2V3YA 4IKRA 4IKUA 1R5HA 2B3LA 4FLJA 3CTZA 3FMRA 2GG8A 2Q92A 1WLRA 3D27A 4S2RP 5CE6A 2BWYA 2Q95A 2G6PA 1WN1A 1KQ0A 1QXWA 2ADUA 4IKTA 1QZYA 5CLSA 1B6AA 2Q94A 1WBQA 1N51A 2B3HA 4MATA 3BIPA 2B3KA 3L7GA 3RVAA 4ZNGA 4RZYA 2GA2A 1A16A 1BOAA 4U6ZA 2IW2A 4A6VA 4B28A 2GG9A 3FMQA 2BH3A 4IKSA 2GG7A 2GG0A 2EA4A 5E5BA 4ZWOA 4U69A 4FO8A 4EGEA 2GZ5A 1WKMA 3BIQA 2BHBA 4FLLA 2V6CA 3PKCA 3Q6DA 5FCHA 3TAVA 2BWUA 3MR1A 4PV4A 2BB7A 2GG2A 1BN5A 4U6WA 4U75A 2BHDA 4U6JA 4U76A 1MATA 2BWWA 5CDEA 4FO7A 4QR8A 3MX6A 2EVCA 3IU8A 2GU4A 2P98A 2Q96A 2EA2A 1QXZA 4IF7A 4R60A 1YVMA 2ZSGA 5JFRA 1O0XA 1XGOA 1CHMA 3L24A 2GU7A 2DFIA 4FUKA 2Q8KA 4HXXA 4A6WA 1XNZA 2HOWA 4KM3A 5FCFA 1JAWA 2GTXA 4RZZA 1WY2A 4S01A 2MATA 2OAZA 5JHUA 3IU9A 3S6BA 1C23A 4U6CA 2P9AA 4S2TP 2BWSA 4Z7MA 2Q93A 2EVMA 3CB6A 5CIKA 4IPAA 4U71A 1W2MA 1C21A 5CDVA 2BWXA 2BWTA 3FM3A 4FKCA 4ZWPA 4U6EA 2GG5A 2GGBA 1XGSA 3BITA 4IDYA 1KP0A 5D6FA 2NQ7A 4IU6A 1YW8A 4U1BA 4U73A 1KQ9A 4S00A
chains in the Genus database with same CATH superfamily
2OKNA 1R5GA 3IU7A 1M35A 5CDLA 2V3ZA 4PNCA 2GU6A 1Y1NA 1B59A 2BHCA 1YW9A 2GG3A 1XGMA 3MATA 4FLIA 2BN7A 5D6EA 2NQ6A 1C24A 1PV9A 1W7VA 3PKEA 3TB5A 2V3XA 5CNXA 4RGZ1 1XGNA 4ZWUA 2BHAA 1WL9A 1C27A 3PKAA 1QXYA 1YW7A 1YJ3A 3CB5A 3PKBA 3IG4A 3PKDA 1R58A 2GGCA 5JI6A 1C22A 1WL6A 2GU5A 2P99A 4JUQA 4FLKA 2BWVA 3RORA 4OOKA 4IECA 2EVOA 4U70A 2V3YA 4IKRA 4IKUA 1R5HA 2B3LA 4FLJA 3CTZA 3FMRA 2GG8A 2Q92A 1WLRA 3D27A 4S2RP 5CE6A 2BWYA 2Q95A 2G6PA 1WN1A 1KQ0A 1QXWA 2ADUA 4IKTA 1QZYA 5CLSA 1B6AA 2Q94A 1WBQA 1N51A 2B3HA 4MATA 3BIPA 2B3KA 3L7GA 3RVAA 4ZNGA 4RZYA 2GA2A 1A16A 1BOAA 4U6ZA 2IW2A 4A6VA 4B28A 2GG9A 3FMQA 2BH3A 4IKSA 2GG7A 2GG0A 2EA4A 5E5BA 4ZWOA 4U69A 4FO8A 4EGEA 2GZ5A 1WKMA 3BIQA 2BHBA 4FLLA 2V6CA 3PKCA 3Q6DA 5FCHA 3TAVA 2BWUA 3MR1A 4PV4A 2BB7A 2GG2A 1BN5A 4U6WA 4U75A 2BHDA 4U6JA 4U76A 1MATA 2BWWA 5CDEA 4FO7A 4QR8A 3MX6A 2EVCA 3IU8A 2GU4A 2P98A 2Q96A 2EA2A 1QXZA 4IF7A 4R60A 1YVMA 2ZSGA 5JFRA 1O0XA 1XGOA 1CHMA 3L24A 2GU7A 2DFIA 4FUKA 2Q8KA 4HXXA 4A6WA 1XNZA 2HOWA 4KM3A 5FCFA 1JAWA 2GTXA 4RZZA 1WY2A 4S01A 2MATA 2OAZA 5JHUA 3IU9A 3S6BA 1C23A 4U6CA 2P9AA 4S2TP 2BWSA 4Z7MA 2Q93A 2EVMA 3CB6A 5CIKA 4IPAA 4U71A 1W2MA 1C21A 5CDVA 2BWXA 2BWTA 3FM3A 4FKCA 4ZWPA 4U6EA 2GG5A 2GGBA 1XGSA 3BITA 4IDYA 1KP0A 5D6FA 2NQ7A 4IU6A 1YW8A 4U1BA 4U73A 1KQ9A 4S00A
chains in the Genus database with same CATH topology
2OKNA 1R5GA 3IU7A 1M35A 5CDLA 2V3ZA 4PNCA 2GU6A 1Y1NA 1B59A 2BHCA 1YW9A 2GG3A 1XGMA 3MATA 4FLIA 2BN7A 5D6EA 2NQ6A 1C24A 1PV9A 1W7VA 3PKEA 3TB5A 2V3XA 5CNXA 4RGZ1 1XGNA 4ZWUA 2BHAA 1WL9A 1C27A 3PKAA 1QXYA 1YW7A 1YJ3A 3CB5A 3PKBA 3IG4A 3PKDA 1R58A 2GGCA 5JI6A 1C22A 1WL6A 2GU5A 2P99A 4JUQA 4FLKA 2BWVA 3RORA 4OOKA 4IECA 2EVOA 4U70A 2V3YA 4IKRA 4IKUA 1R5HA 2B3LA 4FLJA 3CTZA 3FMRA 2GG8A 2Q92A 1WLRA 3D27A 4S2RP 5CE6A 2BWYA 2Q95A 2G6PA 1WN1A 1KQ0A 1QXWA 2ADUA 4IKTA 1QZYA 5CLSA 1B6AA 2Q94A 1WBQA 1N51A 2B3HA 4MATA 3BIPA 2B3KA 3L7GA 3RVAA 4ZNGA 4RZYA 2GA2A 1A16A 1BOAA 4U6ZA 2IW2A 4A6VA 4B28A 2GG9A 3FMQA 2BH3A 4IKSA 2GG7A 2GG0A 2EA4A 5E5BA 4ZWOA 4U69A 4FO8A 4EGEA 2GZ5A 1WKMA 3BIQA 2BHBA 4FLLA 2V6CA 3PKCA 3Q6DA 5FCHA 3TAVA 2BWUA 3MR1A 4PV4A 2BB7A 2GG2A 1BN5A 4U6WA 4U75A 2BHDA 4U6JA 4U76A 1MATA 2BWWA 5CDEA 4FO7A 4QR8A 3MX6A 2EVCA 3IU8A 2GU4A 2P98A 2Q96A 2EA2A 1QXZA 4IF7A 4R60A 1YVMA 2ZSGA 5JFRA 1O0XA 1XGOA 1CHMA 3L24A 2GU7A 2DFIA 4FUKA 2Q8KA 4HXXA 4A6WA 1XNZA 2HOWA 4KM3A 5FCFA 1JAWA 2GTXA 4RZZA 1WY2A 4S01A 2MATA 2OAZA 5JHUA 3IU9A 3S6BA 1C23A 4U6CA 2P9AA 4S2TP 2BWSA 4Z7MA 2Q93A 2EVMA 3CB6A 5CIKA 4IPAA 4U71A 1W2MA 1C21A 5CDVA 2BWXA 2BWTA 3FM3A 4FKCA 4ZWPA 4U6EA 2GG5A 2GGBA 1XGSA 3BITA 4IDYA 1KP0A 5D6FA 2NQ7A 4IU6A 1YW8A 4U1BA 4U73A 1KQ9A 4S00A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2OKN A;  1R5G A;  3IU7 A;  1M35 A;  5CDL A;  2V3Z A;  4PNC A;  2GU6 A;  1Y1N A;  1B59 A;  2BHC A;  1YW9 A;  2GG3 A;  1XGM A;  3MAT A;  4FLI A;  2BN7 A;  5D6E A;  2NQ6 A;  1C24 A;  1PV9 A;  1W7V A;  3PKE A;  3TB5 A;  2V3X A;  5CNX A;  4RGZ 1;  1XGN A;  4ZWU A;  2BHA A;  1WL9 A;  1C27 A;  3PKA A;  1QXY A;  1YW7 A;  1YJ3 A;  3CB5 A;  3PKB A;  3IG4 A;  3PKD A;  1R58 A;  2GGC A;  5JI6 A;  1C22 A;  1WL6 A;  2GU5 A;  2P99 A;  4JUQ A;  4FLK A;  2BWV A;  3ROR A;  4OOK A;  4IEC A;  2EVO A;  4U70 A;  2V3Y A;  4IKR A;  4IKU A;  1R5H A;  2B3L A;  4FLJ A;  3CTZ A;  3FMR A;  2GG8 A;  2Q92 A;  1WLR A;  3D27 A;  4S2R P;  5CE6 A;  2BWY A;  2Q95 A;  2G6P A;  1WN1 A;  1KQ0 A;  1QXW A;  2ADU A;  4IKT A;  1QZY A;  5CLS A;  1B6A A;  2Q94 A;  1WBQ A;  1N51 A;  2B3H A;  4MAT A;  3BIP A;  2B3K A;  3L7G A;  3RVA A;  4ZNG A;  4RZY A;  2GA2 A;  1A16 A;  1BOA A;  4U6Z A;  2IW2 A;  4A6V A;  4B28 A;  2GG9 A;  3FMQ A;  2BH3 A;  4IKS A;  2GG7 A;  2GG0 A;  2EA4 A;  5E5B A;  4ZWO A;  4U69 A;  4FO8 A;  4EGE A;  2GZ5 A;  1WKM A;  3BIQ A;  2BHB A;  4FLL A;  2V6C A;  3PKC A;  3Q6D A;  5FCH A;  3TAV A;  2BWU A;  3MR1 A;  4PV4 A;  2BB7 A;  2GG2 A;  1BN5 A;  4U6W A;  4U75 A;  2BHD A;  4U6J A;  4U76 A;  1MAT A;  2BWW A;  5CDE A;  4FO7 A;  4QR8 A;  3MX6 A;  2EVC A;  3IU8 A;  2GU4 A;  2P98 A;  2Q96 A;  2EA2 A;  1QXZ A;  4IF7 A;  4R60 A;  1YVM A;  2ZSG A;  5JFR A;  1O0X A;  1XGO A;  1CHM A;  3L24 A;  2GU7 A;  2DFI A;  4FUK A;  2Q8K A;  4HXX A;  4A6W A;  1XNZ A;  2HOW A;  4KM3 A;  5FCF A;  1JAW A;  2GTX A;  4RZZ A;  1WY2 A;  4S01 A;  2MAT A;  2OAZ A;  5JHU A;  3IU9 A;  3S6B A;  1C23 A;  4U6C A;  2P9A A;  4S2T P;  2BWS A;  4Z7M A;  2Q93 A;  2EVM A;  3CB6 A;  5CIK A;  4IPA A;  4U71 A;  1W2M A;  1C21 A;  5CDV A;  2BWX A;  2BWT A;  3FM3 A;  4FKC A;  4ZWP A;  4U6E A;  2GG5 A;  2GGB A;  1XGS A;  3BIT A;  4IDY A;  1KP0 A;  5D6F A;  2NQ7 A;  4IU6 A;  1YW8 A;  4U1B A;  4U73 A;  1KQ9 A;  4S00 A; 
#chains in the Genus database with same CATH topology
 2OKN A;  1R5G A;  3IU7 A;  1M35 A;  5CDL A;  2V3Z A;  4PNC A;  2GU6 A;  1Y1N A;  1B59 A;  2BHC A;  1YW9 A;  2GG3 A;  1XGM A;  3MAT A;  4FLI A;  2BN7 A;  5D6E A;  2NQ6 A;  1C24 A;  1PV9 A;  1W7V A;  3PKE A;  3TB5 A;  2V3X A;  5CNX A;  4RGZ 1;  1XGN A;  4ZWU A;  2BHA A;  1WL9 A;  1C27 A;  3PKA A;  1QXY A;  1YW7 A;  1YJ3 A;  3CB5 A;  3PKB A;  3IG4 A;  3PKD A;  1R58 A;  2GGC A;  5JI6 A;  1C22 A;  1WL6 A;  2GU5 A;  2P99 A;  4JUQ A;  4FLK A;  2BWV A;  3ROR A;  4OOK A;  4IEC A;  2EVO A;  4U70 A;  2V3Y A;  4IKR A;  4IKU A;  1R5H A;  2B3L A;  4FLJ A;  3CTZ A;  3FMR A;  2GG8 A;  2Q92 A;  1WLR A;  3D27 A;  4S2R P;  5CE6 A;  2BWY A;  2Q95 A;  2G6P A;  1WN1 A;  1KQ0 A;  1QXW A;  2ADU A;  4IKT A;  1QZY A;  5CLS A;  1B6A A;  2Q94 A;  1WBQ A;  1N51 A;  2B3H A;  4MAT A;  3BIP A;  2B3K A;  3L7G A;  3RVA A;  4ZNG A;  4RZY A;  2GA2 A;  1A16 A;  1BOA A;  4U6Z A;  2IW2 A;  4A6V A;  4B28 A;  2GG9 A;  3FMQ A;  2BH3 A;  4IKS A;  2GG7 A;  2GG0 A;  2EA4 A;  5E5B A;  4ZWO A;  4U69 A;  4FO8 A;  4EGE A;  2GZ5 A;  1WKM A;  3BIQ A;  2BHB A;  4FLL A;  2V6C A;  3PKC A;  3Q6D A;  5FCH A;  3TAV A;  2BWU A;  3MR1 A;  4PV4 A;  2BB7 A;  2GG2 A;  1BN5 A;  4U6W A;  4U75 A;  2BHD A;  4U6J A;  4U76 A;  1MAT A;  2BWW A;  5CDE A;  4FO7 A;  4QR8 A;  3MX6 A;  2EVC A;  3IU8 A;  2GU4 A;  2P98 A;  2Q96 A;  2EA2 A;  1QXZ A;  4IF7 A;  4R60 A;  1YVM A;  2ZSG A;  5JFR A;  1O0X A;  1XGO A;  1CHM A;  3L24 A;  2GU7 A;  2DFI A;  4FUK A;  2Q8K A;  4HXX A;  4A6W A;  1XNZ A;  2HOW A;  4KM3 A;  5FCF A;  1JAW A;  2GTX A;  4RZZ A;  1WY2 A;  4S01 A;  2MAT A;  2OAZ A;  5JHU A;  3IU9 A;  3S6B A;  1C23 A;  4U6C A;  2P9A A;  4S2T P;  2BWS A;  4Z7M A;  2Q93 A;  2EVM A;  3CB6 A;  5CIK A;  4IPA A;  4U71 A;  1W2M A;  1C21 A;  5CDV A;  2BWX A;  2BWT A;  3FM3 A;  4FKC A;  4ZWP A;  4U6E A;  2GG5 A;  2GGB A;  1XGS A;  3BIT A;  4IDY A;  1KP0 A;  5D6F A;  2NQ7 A;  4IU6 A;  1YW8 A;  4U1B A;  4U73 A;  1KQ9 A;  4S00 A; 
#chains in the Genus database with same CATH homology
 2OKN A;  1R5G A;  3IU7 A;  1M35 A;  5CDL A;  2V3Z A;  4PNC A;  2GU6 A;  1Y1N A;  1B59 A;  2BHC A;  1YW9 A;  2GG3 A;  1XGM A;  3MAT A;  4FLI A;  2BN7 A;  5D6E A;  2NQ6 A;  1C24 A;  1PV9 A;  1W7V A;  3PKE A;  3TB5 A;  2V3X A;  5CNX A;  4RGZ 1;  1XGN A;  4ZWU A;  2BHA A;  1WL9 A;  1C27 A;  3PKA A;  1QXY A;  1YW7 A;  1YJ3 A;  3CB5 A;  3PKB A;  3IG4 A;  3PKD A;  1R58 A;  2GGC A;  5JI6 A;  1C22 A;  1WL6 A;  2GU5 A;  2P99 A;  4JUQ A;  4FLK A;  2BWV A;  3ROR A;  4OOK A;  4IEC A;  2EVO A;  4U70 A;  2V3Y A;  4IKR A;  4IKU A;  1R5H A;  2B3L A;  4FLJ A;  3CTZ A;  3FMR A;  2GG8 A;  2Q92 A;  1WLR A;  3D27 A;  4S2R P;  5CE6 A;  2BWY A;  2Q95 A;  2G6P A;  1WN1 A;  1KQ0 A;  1QXW A;  2ADU A;  4IKT A;  1QZY A;  5CLS A;  1B6A A;  2Q94 A;  1WBQ A;  1N51 A;  2B3H A;  4MAT A;  3BIP A;  2B3K A;  3L7G A;  3RVA A;  4ZNG A;  4RZY A;  2GA2 A;  1A16 A;  1BOA A;  4U6Z A;  2IW2 A;  4A6V A;  4B28 A;  2GG9 A;  3FMQ A;  2BH3 A;  4IKS A;  2GG7 A;  2GG0 A;  2EA4 A;  5E5B A;  4ZWO A;  4U69 A;  4FO8 A;  4EGE A;  2GZ5 A;  1WKM A;  3BIQ A;  2BHB A;  4FLL A;  2V6C A;  3PKC A;  3Q6D A;  5FCH A;  3TAV A;  2BWU A;  3MR1 A;  4PV4 A;  2BB7 A;  2GG2 A;  1BN5 A;  4U6W A;  4U75 A;  2BHD A;  4U6J A;  4U76 A;  1MAT A;  2BWW A;  5CDE A;  4FO7 A;  4QR8 A;  3MX6 A;  2EVC A;  3IU8 A;  2GU4 A;  2P98 A;  2Q96 A;  2EA2 A;  1QXZ A;  4IF7 A;  4R60 A;  1YVM A;  2ZSG A;  5JFR A;  1O0X A;  1XGO A;  1CHM A;  3L24 A;  2GU7 A;  2DFI A;  4FUK A;  2Q8K A;  4HXX A;  4A6W A;  1XNZ A;  2HOW A;  4KM3 A;  5FCF A;  1JAW A;  2GTX A;  4RZZ A;  1WY2 A;  4S01 A;  2MAT A;  2OAZ A;  5JHU A;  3IU9 A;  3S6B A;  1C23 A;  4U6C A;  2P9A A;  4S2T P;  2BWS A;  4Z7M A;  2Q93 A;  2EVM A;  3CB6 A;  5CIK A;  4IPA A;  4U71 A;  1W2M A;  1C21 A;  5CDV A;  2BWX A;  2BWT A;  3FM3 A;  4FKC A;  4ZWP A;  4U6E A;  2GG5 A;  2GGB A;  1XGS A;  3BIT A;  4IDY A;  1KP0 A;  5D6F A;  2NQ7 A;  4IU6 A;  1YW8 A;  4U1B A;  4U73 A;  1KQ9 A;  4S00 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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