2P99A

E. coli methionine aminopeptidase monometalated with inhibitor ye6
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 85
structure length 261
sequence length 261
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p99A00
3MX6A 2P98A 1YW9A 2BWUA 4IDYA 3IU9A 2MATA 2EA4A 3Q6DA 4JUQA 4U70A 1JAWA 4S01A 4U76A 2GG9A 2Q92A 4FO8A 3L24A 2G6PA 4EGEA 1R5GA 3BITA 2BWVA 4KM3A 2OKNA 1XNZA 3FMRA 3BIPA 4IF7A 4U6EA 3CB5A 2GG0A 4ZNGA 1WL6A 1BN5A 4FLLA 2IW2A 2EVCA 2GG5A 2GTXA 2GU7A 4B28A 1QXYA 3TB5A 2EVMA 2GGBA 4U71A 2P9AA 4U6JA 1M35A 1XGNA 1C22A 1C23A 3BIQA 4IPAA 2V3YA 4U75A 1QXWA 4S2RP 5CDVA 4A6VA 1WL9A 1KQ0A 3PKAA 2GG8A 1KP0A 4PNCA 1QXZA 3L7GA 5D6FA 4FUKA 1QZYA 4PV4A 3FMQA 1XGMA 2Q94A 1O0XA 2BWTA 1WBQA 4A6WA 2BWYA 2P99A 3MR1A 1N51A 2B3LA 4U6CA 2Q95A 2HOWA 4U6ZA 4RZZA 5FCHA 1W2MA 2ADUA 4U69A 4RGZ1 1CHMA 2GU6A 3IU8A 4FLJA 1C21A 2BWSA 1WY2A 1KQ9A 1WLRA 2GU5A 1BOAA 2Q93A 2GA2A 3CB6A 2V6CA 5CNXA 2GG3A 2BHBA 1WKMA 2B3HA 4IECA 1XGOA 4ZWUA 2GZ5A 3FM3A 3PKBA 5JFRA 2V3ZA 1A16A 4QR8A 2GU4A 2GG7A 2Q96A 4IKRA 1B59A 4R60A 4IU6A 4S00A 3CTZA 3IU7A 3IG4A 4U1BA 5FCFA 2NQ6A 5CLSA 1WN1A 2V3XA 2BHAA 4U73A 4IKSA 4IKTA 2BHCA 2BN7A 3D27A 4Z7MA 5CDLA 2Q8KA 3RVAA 5CE6A 2BWWA 5JI6A 2ZSGA 1R58A 1YJ3A 2NQ7A 2OAZA 4RZYA 4S2TP 2EA2A 5CDEA 1YVMA 1YW7A 1R5HA 4FKCA 1Y1NA 5JHUA 2BHDA 5D6EA 5CIKA 1YW8A 3TAVA 3RORA 4ZWOA 3PKEA 1XGSA 2BH3A 4FO7A 4IKUA 2BB7A 1MATA 2BWXA 2EVOA 1C27A 5E5BA 1PV9A 4FLIA 1C24A 4HXXA 4FLKA 3MATA 3PKCA 4MATA 1W7VA 2DFIA 3PKDA 2B3KA 2GGCA 2GG2A 3S6BA 1B6AA 4U6WA 4ZWPA 4OOKA
chains in the Genus database with same CATH superfamily
3MX6A 2P98A 1YW9A 2BWUA 4IDYA 3IU9A 2MATA 2EA4A 3Q6DA 4JUQA 4U70A 1JAWA 4S01A 4U76A 2GG9A 2Q92A 4FO8A 3L24A 2G6PA 4EGEA 1R5GA 3BITA 2BWVA 4KM3A 2OKNA 1XNZA 3FMRA 3BIPA 4IF7A 4U6EA 3CB5A 2GG0A 4ZNGA 1WL6A 1BN5A 4FLLA 2IW2A 2EVCA 2GG5A 2GTXA 2GU7A 4B28A 1QXYA 3TB5A 2EVMA 2GGBA 4U71A 2P9AA 4U6JA 1M35A 1XGNA 1C22A 1C23A 3BIQA 4IPAA 2V3YA 4U75A 1QXWA 4S2RP 5CDVA 4A6VA 1WL9A 1KQ0A 3PKAA 2GG8A 1KP0A 4PNCA 1QXZA 3L7GA 5D6FA 4FUKA 1QZYA 4PV4A 3FMQA 1XGMA 2Q94A 1O0XA 2BWTA 1WBQA 4A6WA 2BWYA 2P99A 3MR1A 1N51A 2B3LA 4U6CA 2Q95A 2HOWA 4U6ZA 4RZZA 5FCHA 1W2MA 2ADUA 4U69A 4RGZ1 1CHMA 2GU6A 3IU8A 4FLJA 1C21A 2BWSA 1WY2A 1KQ9A 1WLRA 2GU5A 1BOAA 2Q93A 2GA2A 3CB6A 2V6CA 5CNXA 2GG3A 2BHBA 1WKMA 2B3HA 4IECA 1XGOA 4ZWUA 2GZ5A 3FM3A 3PKBA 5JFRA 2V3ZA 1A16A 4QR8A 2GU4A 2GG7A 2Q96A 4IKRA 1B59A 4R60A 4IU6A 4S00A 3CTZA 3IU7A 3IG4A 4U1BA 5FCFA 2NQ6A 5CLSA 1WN1A 2V3XA 2BHAA 4U73A 4IKSA 4IKTA 2BHCA 2BN7A 3D27A 4Z7MA 5CDLA 2Q8KA 3RVAA 5CE6A 2BWWA 5JI6A 2ZSGA 1R58A 1YJ3A 2NQ7A 2OAZA 4RZYA 4S2TP 2EA2A 5CDEA 1YVMA 1YW7A 1R5HA 4FKCA 1Y1NA 5JHUA 2BHDA 5D6EA 5CIKA 1YW8A 3TAVA 3RORA 4ZWOA 3PKEA 1XGSA 2BH3A 4FO7A 4IKUA 2BB7A 1MATA 2BWXA 2EVOA 1C27A 5E5BA 1PV9A 4FLIA 1C24A 4HXXA 4FLKA 3MATA 3PKCA 4MATA 1W7VA 2DFIA 3PKDA 2B3KA 2GGCA 2GG2A 3S6BA 1B6AA 4U6WA 4ZWPA 4OOKA
chains in the Genus database with same CATH topology
3MX6A 2P98A 1YW9A 2BWUA 4IDYA 3IU9A 2MATA 2EA4A 3Q6DA 4JUQA 4U70A 1JAWA 4S01A 4U76A 2GG9A 2Q92A 4FO8A 3L24A 2G6PA 4EGEA 1R5GA 3BITA 2BWVA 4KM3A 2OKNA 1XNZA 3FMRA 3BIPA 4IF7A 4U6EA 3CB5A 2GG0A 4ZNGA 1WL6A 1BN5A 4FLLA 2IW2A 2EVCA 2GG5A 2GTXA 2GU7A 4B28A 1QXYA 3TB5A 2EVMA 2GGBA 4U71A 2P9AA 4U6JA 1M35A 1XGNA 1C22A 1C23A 3BIQA 4IPAA 2V3YA 4U75A 1QXWA 4S2RP 5CDVA 4A6VA 1WL9A 1KQ0A 3PKAA 2GG8A 1KP0A 4PNCA 1QXZA 3L7GA 5D6FA 4FUKA 1QZYA 4PV4A 3FMQA 1XGMA 2Q94A 1O0XA 2BWTA 1WBQA 4A6WA 2BWYA 2P99A 3MR1A 1N51A 2B3LA 4U6CA 2Q95A 2HOWA 4U6ZA 4RZZA 5FCHA 1W2MA 2ADUA 4U69A 4RGZ1 1CHMA 2GU6A 3IU8A 4FLJA 1C21A 2BWSA 1WY2A 1KQ9A 1WLRA 2GU5A 1BOAA 2Q93A 2GA2A 3CB6A 2V6CA 5CNXA 2GG3A 2BHBA 1WKMA 2B3HA 4IECA 1XGOA 4ZWUA 2GZ5A 3FM3A 3PKBA 5JFRA 2V3ZA 1A16A 4QR8A 2GU4A 2GG7A 2Q96A 4IKRA 1B59A 4R60A 4IU6A 4S00A 3CTZA 3IU7A 3IG4A 4U1BA 5FCFA 2NQ6A 5CLSA 1WN1A 2V3XA 2BHAA 4U73A 4IKSA 4IKTA 2BHCA 2BN7A 3D27A 4Z7MA 5CDLA 2Q8KA 3RVAA 5CE6A 2BWWA 5JI6A 2ZSGA 1R58A 1YJ3A 2NQ7A 2OAZA 4RZYA 4S2TP 2EA2A 5CDEA 1YVMA 1YW7A 1R5HA 4FKCA 1Y1NA 5JHUA 2BHDA 5D6EA 5CIKA 1YW8A 3TAVA 3RORA 4ZWOA 3PKEA 1XGSA 2BH3A 4FO7A 4IKUA 2BB7A 1MATA 2BWXA 2EVOA 1C27A 5E5BA 1PV9A 4FLIA 1C24A 4HXXA 4FLKA 3MATA 3PKCA 4MATA 1W7VA 2DFIA 3PKDA 2B3KA 2GGCA 2GG2A 3S6BA 1B6AA 4U6WA 4ZWPA 4OOKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MX6 A;  2P98 A;  1YW9 A;  2BWU A;  4IDY A;  3IU9 A;  2MAT A;  2EA4 A;  3Q6D A;  4JUQ A;  4U70 A;  1JAW A;  4S01 A;  4U76 A;  2GG9 A;  2Q92 A;  4FO8 A;  3L24 A;  2G6P A;  4EGE A;  1R5G A;  3BIT A;  2BWV A;  4KM3 A;  2OKN A;  1XNZ A;  3FMR A;  3BIP A;  4IF7 A;  4U6E A;  3CB5 A;  2GG0 A;  4ZNG A;  1WL6 A;  1BN5 A;  4FLL A;  2IW2 A;  2EVC A;  2GG5 A;  2GTX A;  2GU7 A;  4B28 A;  1QXY A;  3TB5 A;  2EVM A;  2GGB A;  4U71 A;  2P9A A;  4U6J A;  1M35 A;  1XGN A;  1C22 A;  1C23 A;  3BIQ A;  4IPA A;  2V3Y A;  4U75 A;  1QXW A;  4S2R P;  5CDV A;  4A6V A;  1WL9 A;  1KQ0 A;  3PKA A;  2GG8 A;  1KP0 A;  4PNC A;  1QXZ A;  3L7G A;  5D6F A;  4FUK A;  1QZY A;  4PV4 A;  3FMQ A;  1XGM A;  2Q94 A;  1O0X A;  2BWT A;  1WBQ A;  4A6W A;  2BWY A;  2P99 A;  3MR1 A;  1N51 A;  2B3L A;  4U6C A;  2Q95 A;  2HOW A;  4U6Z A;  4RZZ A;  5FCH A;  1W2M A;  2ADU A;  4U69 A;  4RGZ 1;  1CHM A;  2GU6 A;  3IU8 A;  4FLJ A;  1C21 A;  2BWS A;  1WY2 A;  1KQ9 A;  1WLR A;  2GU5 A;  1BOA A;  2Q93 A;  2GA2 A;  3CB6 A;  2V6C A;  5CNX A;  2GG3 A;  2BHB A;  1WKM A;  2B3H A;  4IEC A;  1XGO A;  4ZWU A;  2GZ5 A;  3FM3 A;  3PKB A;  5JFR A;  2V3Z A;  1A16 A;  4QR8 A;  2GU4 A;  2GG7 A;  2Q96 A;  4IKR A;  1B59 A;  4R60 A;  4IU6 A;  4S00 A;  3CTZ A;  3IU7 A;  3IG4 A;  4U1B A;  5FCF A;  2NQ6 A;  5CLS A;  1WN1 A;  2V3X A;  2BHA A;  4U73 A;  4IKS A;  4IKT A;  2BHC A;  2BN7 A;  3D27 A;  4Z7M A;  5CDL A;  2Q8K A;  3RVA A;  5CE6 A;  2BWW A;  5JI6 A;  2ZSG A;  1R58 A;  1YJ3 A;  2NQ7 A;  2OAZ A;  4RZY A;  4S2T P;  2EA2 A;  5CDE A;  1YVM A;  1YW7 A;  1R5H A;  4FKC A;  1Y1N A;  5JHU A;  2BHD A;  5D6E A;  5CIK A;  1YW8 A;  3TAV A;  3ROR A;  4ZWO A;  3PKE A;  1XGS A;  2BH3 A;  4FO7 A;  4IKU A;  2BB7 A;  1MAT A;  2BWX A;  2EVO A;  1C27 A;  5E5B A;  1PV9 A;  4FLI A;  1C24 A;  4HXX A;  4FLK A;  3MAT A;  3PKC A;  4MAT A;  1W7V A;  2DFI A;  3PKD A;  2B3K A;  2GGC A;  2GG2 A;  3S6B A;  1B6A A;  4U6W A;  4ZWP A;  4OOK A; 
#chains in the Genus database with same CATH topology
 3MX6 A;  2P98 A;  1YW9 A;  2BWU A;  4IDY A;  3IU9 A;  2MAT A;  2EA4 A;  3Q6D A;  4JUQ A;  4U70 A;  1JAW A;  4S01 A;  4U76 A;  2GG9 A;  2Q92 A;  4FO8 A;  3L24 A;  2G6P A;  4EGE A;  1R5G A;  3BIT A;  2BWV A;  4KM3 A;  2OKN A;  1XNZ A;  3FMR A;  3BIP A;  4IF7 A;  4U6E A;  3CB5 A;  2GG0 A;  4ZNG A;  1WL6 A;  1BN5 A;  4FLL A;  2IW2 A;  2EVC A;  2GG5 A;  2GTX A;  2GU7 A;  4B28 A;  1QXY A;  3TB5 A;  2EVM A;  2GGB A;  4U71 A;  2P9A A;  4U6J A;  1M35 A;  1XGN A;  1C22 A;  1C23 A;  3BIQ A;  4IPA A;  2V3Y A;  4U75 A;  1QXW A;  4S2R P;  5CDV A;  4A6V A;  1WL9 A;  1KQ0 A;  3PKA A;  2GG8 A;  1KP0 A;  4PNC A;  1QXZ A;  3L7G A;  5D6F A;  4FUK A;  1QZY A;  4PV4 A;  3FMQ A;  1XGM A;  2Q94 A;  1O0X A;  2BWT A;  1WBQ A;  4A6W A;  2BWY A;  2P99 A;  3MR1 A;  1N51 A;  2B3L A;  4U6C A;  2Q95 A;  2HOW A;  4U6Z A;  4RZZ A;  5FCH A;  1W2M A;  2ADU A;  4U69 A;  4RGZ 1;  1CHM A;  2GU6 A;  3IU8 A;  4FLJ A;  1C21 A;  2BWS A;  1WY2 A;  1KQ9 A;  1WLR A;  2GU5 A;  1BOA A;  2Q93 A;  2GA2 A;  3CB6 A;  2V6C A;  5CNX A;  2GG3 A;  2BHB A;  1WKM A;  2B3H A;  4IEC A;  1XGO A;  4ZWU A;  2GZ5 A;  3FM3 A;  3PKB A;  5JFR A;  2V3Z A;  1A16 A;  4QR8 A;  2GU4 A;  2GG7 A;  2Q96 A;  4IKR A;  1B59 A;  4R60 A;  4IU6 A;  4S00 A;  3CTZ A;  3IU7 A;  3IG4 A;  4U1B A;  5FCF A;  2NQ6 A;  5CLS A;  1WN1 A;  2V3X A;  2BHA A;  4U73 A;  4IKS A;  4IKT A;  2BHC A;  2BN7 A;  3D27 A;  4Z7M A;  5CDL A;  2Q8K A;  3RVA A;  5CE6 A;  2BWW A;  5JI6 A;  2ZSG A;  1R58 A;  1YJ3 A;  2NQ7 A;  2OAZ A;  4RZY A;  4S2T P;  2EA2 A;  5CDE A;  1YVM A;  1YW7 A;  1R5H A;  4FKC A;  1Y1N A;  5JHU A;  2BHD A;  5D6E A;  5CIK A;  1YW8 A;  3TAV A;  3ROR A;  4ZWO A;  3PKE A;  1XGS A;  2BH3 A;  4FO7 A;  4IKU A;  2BB7 A;  1MAT A;  2BWX A;  2EVO A;  1C27 A;  5E5B A;  1PV9 A;  4FLI A;  1C24 A;  4HXX A;  4FLK A;  3MAT A;  3PKC A;  4MAT A;  1W7V A;  2DFI A;  3PKD A;  2B3K A;  2GGC A;  2GG2 A;  3S6B A;  1B6A A;  4U6W A;  4ZWP A;  4OOK A; 
#chains in the Genus database with same CATH homology
 3MX6 A;  2P98 A;  1YW9 A;  2BWU A;  4IDY A;  3IU9 A;  2MAT A;  2EA4 A;  3Q6D A;  4JUQ A;  4U70 A;  1JAW A;  4S01 A;  4U76 A;  2GG9 A;  2Q92 A;  4FO8 A;  3L24 A;  2G6P A;  4EGE A;  1R5G A;  3BIT A;  2BWV A;  4KM3 A;  2OKN A;  1XNZ A;  3FMR A;  3BIP A;  4IF7 A;  4U6E A;  3CB5 A;  2GG0 A;  4ZNG A;  1WL6 A;  1BN5 A;  4FLL A;  2IW2 A;  2EVC A;  2GG5 A;  2GTX A;  2GU7 A;  4B28 A;  1QXY A;  3TB5 A;  2EVM A;  2GGB A;  4U71 A;  2P9A A;  4U6J A;  1M35 A;  1XGN A;  1C22 A;  1C23 A;  3BIQ A;  4IPA A;  2V3Y A;  4U75 A;  1QXW A;  4S2R P;  5CDV A;  4A6V A;  1WL9 A;  1KQ0 A;  3PKA A;  2GG8 A;  1KP0 A;  4PNC A;  1QXZ A;  3L7G A;  5D6F A;  4FUK A;  1QZY A;  4PV4 A;  3FMQ A;  1XGM A;  2Q94 A;  1O0X A;  2BWT A;  1WBQ A;  4A6W A;  2BWY A;  2P99 A;  3MR1 A;  1N51 A;  2B3L A;  4U6C A;  2Q95 A;  2HOW A;  4U6Z A;  4RZZ A;  5FCH A;  1W2M A;  2ADU A;  4U69 A;  4RGZ 1;  1CHM A;  2GU6 A;  3IU8 A;  4FLJ A;  1C21 A;  2BWS A;  1WY2 A;  1KQ9 A;  1WLR A;  2GU5 A;  1BOA A;  2Q93 A;  2GA2 A;  3CB6 A;  2V6C A;  5CNX A;  2GG3 A;  2BHB A;  1WKM A;  2B3H A;  4IEC A;  1XGO A;  4ZWU A;  2GZ5 A;  3FM3 A;  3PKB A;  5JFR A;  2V3Z A;  1A16 A;  4QR8 A;  2GU4 A;  2GG7 A;  2Q96 A;  4IKR A;  1B59 A;  4R60 A;  4IU6 A;  4S00 A;  3CTZ A;  3IU7 A;  3IG4 A;  4U1B A;  5FCF A;  2NQ6 A;  5CLS A;  1WN1 A;  2V3X A;  2BHA A;  4U73 A;  4IKS A;  4IKT A;  2BHC A;  2BN7 A;  3D27 A;  4Z7M A;  5CDL A;  2Q8K A;  3RVA A;  5CE6 A;  2BWW A;  5JI6 A;  2ZSG A;  1R58 A;  1YJ3 A;  2NQ7 A;  2OAZ A;  4RZY A;  4S2T P;  2EA2 A;  5CDE A;  1YVM A;  1YW7 A;  1R5H A;  4FKC A;  1Y1N A;  5JHU A;  2BHD A;  5D6E A;  5CIK A;  1YW8 A;  3TAV A;  3ROR A;  4ZWO A;  3PKE A;  1XGS A;  2BH3 A;  4FO7 A;  4IKU A;  2BB7 A;  1MAT A;  2BWX A;  2EVO A;  1C27 A;  5E5B A;  1PV9 A;  4FLI A;  1C24 A;  4HXX A;  4FLK A;  3MAT A;  3PKC A;  4MAT A;  1W7V A;  2DFI A;  3PKD A;  2B3K A;  2GGC A;  2GG2 A;  3S6B A;  1B6A A;  4U6W A;  4ZWP A;  4OOK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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