2P9AA

E. coli methionine aminopeptidase dimetalated with inhibitor ye6
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p9aA00
5CDLA 2BWYA 2P99A 2BWSA 4IKTA 2Q96A 2BH3A 1WY2A 1Y1NA 2GGBA 2OAZA 1YW7A 4IKSA 3MR1A 1C27A 2BB7A 4A6VA 4OOKA 5E5BA 4FO7A 2GTXA 3S6BA 1KQ9A 4FKCA 4FLLA 2G6PA 1W2MA 2B3LA 5D6FA 2BWVA 1WL9A 2DFIA 2NQ6A 1XGMA 1A16A 4IKRA 2V3YA 4U70A 4U73A 5CIKA 2GG2A 2BWTA 4B28A 4IPAA 2ZSGA 4RZZA 4S2RP 5JHUA 1QXYA 2GGCA 4JUQA 1XGSA 1R5GA 2BHBA 5JI6A 4IECA 3TB5A 5FCHA 4U71A 2EVOA 4IDYA 2Q93A 1O0XA 4S00A 4KM3A 1WLRA 1N51A 1B6AA 4ZWOA 4PV4A 4U6JA 2GG0A 4U6ZA 4RZYA 4A6WA 1QXZA 5CDEA 4EGEA 2GG5A 2B3KA 1R5HA 1C21A 3IU7A 4ZWUA 2BWUA 4ZWPA 2P98A 3PKCA 1PV9A 2HOWA 1KP0A 1XNZA 4FLIA 3TAVA 1QZYA 4QR8A 4IU6A 1JAWA 2BHAA 3BITA 4S01A 5CNXA 1WKMA 4R60A 2Q92A 4HXXA 2GU5A 4PNCA 3IU8A 3RORA 4IKUA 4FUKA 2MATA 2EVCA 1C22A 4FLJA 4FO8A 2GG7A 1YW9A 2Q95A 3MATA 2P9AA 4U6CA 2BWWA 2BHDA 5FCFA 4FLKA 2EVMA 2EA2A 3FMQA 4S2TP 3PKBA 2GG9A 1YW8A 2GU7A 5JFRA 3L24A 3IG4A 3PKEA 2GA2A 3FM3A 2Q94A 2BWXA 2B3HA 1W7VA 1YVMA 3BIQA 3Q6DA 4U6EA 3RVAA 2Q8KA 1KQ0A 4U75A 1C23A 1CHMA 3BIPA 4RGZ1 2GZ5A 1QXWA 1B59A 1M35A 3IU9A 2V6CA 4IF7A 3FMRA 2ADUA 2OKNA 4Z7MA 3CTZA 4ZNGA 2V3ZA 4U1BA 3PKDA 3PKAA 2EA4A 2GU6A 4MATA 5D6EA 1C24A 4U6WA 1XGOA 5CDVA 5CE6A 1WBQA 2BN7A 2V3XA 1WL6A 1WN1A 5CLSA 3D27A 3MX6A 1BN5A 1BOAA 2GU4A 2IW2A 3L7GA 3CB6A 2GG3A 1R58A 3CB5A 2BHCA 2NQ7A 4U76A 2GG8A 4U69A 1YJ3A 1MATA 1XGNA
chains in the Genus database with same CATH superfamily
5CDLA 2BWYA 2P99A 2BWSA 4IKTA 2Q96A 2BH3A 1WY2A 1Y1NA 2GGBA 2OAZA 1YW7A 4IKSA 3MR1A 1C27A 2BB7A 4A6VA 4OOKA 5E5BA 4FO7A 2GTXA 3S6BA 1KQ9A 4FKCA 4FLLA 2G6PA 1W2MA 2B3LA 5D6FA 2BWVA 1WL9A 2DFIA 2NQ6A 1XGMA 1A16A 4IKRA 2V3YA 4U70A 4U73A 5CIKA 2GG2A 2BWTA 4B28A 4IPAA 2ZSGA 4RZZA 4S2RP 5JHUA 1QXYA 2GGCA 4JUQA 1XGSA 1R5GA 2BHBA 5JI6A 4IECA 3TB5A 5FCHA 4U71A 2EVOA 4IDYA 2Q93A 1O0XA 4S00A 4KM3A 1WLRA 1N51A 1B6AA 4ZWOA 4PV4A 4U6JA 2GG0A 4U6ZA 4RZYA 4A6WA 1QXZA 5CDEA 4EGEA 2GG5A 2B3KA 1R5HA 1C21A 3IU7A 4ZWUA 2BWUA 4ZWPA 2P98A 3PKCA 1PV9A 2HOWA 1KP0A 1XNZA 4FLIA 3TAVA 1QZYA 4QR8A 4IU6A 1JAWA 2BHAA 3BITA 4S01A 5CNXA 1WKMA 4R60A 2Q92A 4HXXA 2GU5A 4PNCA 3IU8A 3RORA 4IKUA 4FUKA 2MATA 2EVCA 1C22A 4FLJA 4FO8A 2GG7A 1YW9A 2Q95A 3MATA 2P9AA 4U6CA 2BWWA 2BHDA 5FCFA 4FLKA 2EVMA 2EA2A 3FMQA 4S2TP 3PKBA 2GG9A 1YW8A 2GU7A 5JFRA 3L24A 3IG4A 3PKEA 2GA2A 3FM3A 2Q94A 2BWXA 2B3HA 1W7VA 1YVMA 3BIQA 3Q6DA 4U6EA 3RVAA 2Q8KA 1KQ0A 4U75A 1C23A 1CHMA 3BIPA 4RGZ1 2GZ5A 1QXWA 1B59A 1M35A 3IU9A 2V6CA 4IF7A 3FMRA 2ADUA 2OKNA 4Z7MA 3CTZA 4ZNGA 2V3ZA 4U1BA 3PKDA 3PKAA 2EA4A 2GU6A 4MATA 5D6EA 1C24A 4U6WA 1XGOA 5CDVA 5CE6A 1WBQA 2BN7A 2V3XA 1WL6A 1WN1A 5CLSA 3D27A 3MX6A 1BN5A 1BOAA 2GU4A 2IW2A 3L7GA 3CB6A 2GG3A 1R58A 3CB5A 2BHCA 2NQ7A 4U76A 2GG8A 4U69A 1YJ3A 1MATA 1XGNA
chains in the Genus database with same CATH topology
5CDLA 2BWYA 2P99A 2BWSA 4IKTA 2Q96A 2BH3A 1WY2A 1Y1NA 2GGBA 2OAZA 1YW7A 4IKSA 3MR1A 1C27A 2BB7A 4A6VA 4OOKA 5E5BA 4FO7A 2GTXA 3S6BA 1KQ9A 4FKCA 4FLLA 2G6PA 1W2MA 2B3LA 5D6FA 2BWVA 1WL9A 2DFIA 2NQ6A 1XGMA 1A16A 4IKRA 2V3YA 4U70A 4U73A 5CIKA 2GG2A 2BWTA 4B28A 4IPAA 2ZSGA 4RZZA 4S2RP 5JHUA 1QXYA 2GGCA 4JUQA 1XGSA 1R5GA 2BHBA 5JI6A 4IECA 3TB5A 5FCHA 4U71A 2EVOA 4IDYA 2Q93A 1O0XA 4S00A 4KM3A 1WLRA 1N51A 1B6AA 4ZWOA 4PV4A 4U6JA 2GG0A 4U6ZA 4RZYA 4A6WA 1QXZA 5CDEA 4EGEA 2GG5A 2B3KA 1R5HA 1C21A 3IU7A 4ZWUA 2BWUA 4ZWPA 2P98A 3PKCA 1PV9A 2HOWA 1KP0A 1XNZA 4FLIA 3TAVA 1QZYA 4QR8A 4IU6A 1JAWA 2BHAA 3BITA 4S01A 5CNXA 1WKMA 4R60A 2Q92A 4HXXA 2GU5A 4PNCA 3IU8A 3RORA 4IKUA 4FUKA 2MATA 2EVCA 1C22A 4FLJA 4FO8A 2GG7A 1YW9A 2Q95A 3MATA 2P9AA 4U6CA 2BWWA 2BHDA 5FCFA 4FLKA 2EVMA 2EA2A 3FMQA 4S2TP 3PKBA 2GG9A 1YW8A 2GU7A 5JFRA 3L24A 3IG4A 3PKEA 2GA2A 3FM3A 2Q94A 2BWXA 2B3HA 1W7VA 1YVMA 3BIQA 3Q6DA 4U6EA 3RVAA 2Q8KA 1KQ0A 4U75A 1C23A 1CHMA 3BIPA 4RGZ1 2GZ5A 1QXWA 1B59A 1M35A 3IU9A 2V6CA 4IF7A 3FMRA 2ADUA 2OKNA 4Z7MA 3CTZA 4ZNGA 2V3ZA 4U1BA 3PKDA 3PKAA 2EA4A 2GU6A 4MATA 5D6EA 1C24A 4U6WA 1XGOA 5CDVA 5CE6A 1WBQA 2BN7A 2V3XA 1WL6A 1WN1A 5CLSA 3D27A 3MX6A 1BN5A 1BOAA 2GU4A 2IW2A 3L7GA 3CB6A 2GG3A 1R58A 3CB5A 2BHCA 2NQ7A 4U76A 2GG8A 4U69A 1YJ3A 1MATA 1XGNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CDL A;  2BWY A;  2P99 A;  2BWS A;  4IKT A;  2Q96 A;  2BH3 A;  1WY2 A;  1Y1N A;  2GGB A;  2OAZ A;  1YW7 A;  4IKS A;  3MR1 A;  1C27 A;  2BB7 A;  4A6V A;  4OOK A;  5E5B A;  4FO7 A;  2GTX A;  3S6B A;  1KQ9 A;  4FKC A;  4FLL A;  2G6P A;  1W2M A;  2B3L A;  5D6F A;  2BWV A;  1WL9 A;  2DFI A;  2NQ6 A;  1XGM A;  1A16 A;  4IKR A;  2V3Y A;  4U70 A;  4U73 A;  5CIK A;  2GG2 A;  2BWT A;  4B28 A;  4IPA A;  2ZSG A;  4RZZ A;  4S2R P;  5JHU A;  1QXY A;  2GGC A;  4JUQ A;  1XGS A;  1R5G A;  2BHB A;  5JI6 A;  4IEC A;  3TB5 A;  5FCH A;  4U71 A;  2EVO A;  4IDY A;  2Q93 A;  1O0X A;  4S00 A;  4KM3 A;  1WLR A;  1N51 A;  1B6A A;  4ZWO A;  4PV4 A;  4U6J A;  2GG0 A;  4U6Z A;  4RZY A;  4A6W A;  1QXZ A;  5CDE A;  4EGE A;  2GG5 A;  2B3K A;  1R5H A;  1C21 A;  3IU7 A;  4ZWU A;  2BWU A;  4ZWP A;  2P98 A;  3PKC A;  1PV9 A;  2HOW A;  1KP0 A;  1XNZ A;  4FLI A;  3TAV A;  1QZY A;  4QR8 A;  4IU6 A;  1JAW A;  2BHA A;  3BIT A;  4S01 A;  5CNX A;  1WKM A;  4R60 A;  2Q92 A;  4HXX A;  2GU5 A;  4PNC A;  3IU8 A;  3ROR A;  4IKU A;  4FUK A;  2MAT A;  2EVC A;  1C22 A;  4FLJ A;  4FO8 A;  2GG7 A;  1YW9 A;  2Q95 A;  3MAT A;  2P9A A;  4U6C A;  2BWW A;  2BHD A;  5FCF A;  4FLK A;  2EVM A;  2EA2 A;  3FMQ A;  4S2T P;  3PKB A;  2GG9 A;  1YW8 A;  2GU7 A;  5JFR A;  3L24 A;  3IG4 A;  3PKE A;  2GA2 A;  3FM3 A;  2Q94 A;  2BWX A;  2B3H A;  1W7V A;  1YVM A;  3BIQ A;  3Q6D A;  4U6E A;  3RVA A;  2Q8K A;  1KQ0 A;  4U75 A;  1C23 A;  1CHM A;  3BIP A;  4RGZ 1;  2GZ5 A;  1QXW A;  1B59 A;  1M35 A;  3IU9 A;  2V6C A;  4IF7 A;  3FMR A;  2ADU A;  2OKN A;  4Z7M A;  3CTZ A;  4ZNG A;  2V3Z A;  4U1B A;  3PKD A;  3PKA A;  2EA4 A;  2GU6 A;  4MAT A;  5D6E A;  1C24 A;  4U6W A;  1XGO A;  5CDV A;  5CE6 A;  1WBQ A;  2BN7 A;  2V3X A;  1WL6 A;  1WN1 A;  5CLS A;  3D27 A;  3MX6 A;  1BN5 A;  1BOA A;  2GU4 A;  2IW2 A;  3L7G A;  3CB6 A;  2GG3 A;  1R58 A;  3CB5 A;  2BHC A;  2NQ7 A;  4U76 A;  2GG8 A;  4U69 A;  1YJ3 A;  1MAT A;  1XGN A; 
#chains in the Genus database with same CATH topology
 5CDL A;  2BWY A;  2P99 A;  2BWS A;  4IKT A;  2Q96 A;  2BH3 A;  1WY2 A;  1Y1N A;  2GGB A;  2OAZ A;  1YW7 A;  4IKS A;  3MR1 A;  1C27 A;  2BB7 A;  4A6V A;  4OOK A;  5E5B A;  4FO7 A;  2GTX A;  3S6B A;  1KQ9 A;  4FKC A;  4FLL A;  2G6P A;  1W2M A;  2B3L A;  5D6F A;  2BWV A;  1WL9 A;  2DFI A;  2NQ6 A;  1XGM A;  1A16 A;  4IKR A;  2V3Y A;  4U70 A;  4U73 A;  5CIK A;  2GG2 A;  2BWT A;  4B28 A;  4IPA A;  2ZSG A;  4RZZ A;  4S2R P;  5JHU A;  1QXY A;  2GGC A;  4JUQ A;  1XGS A;  1R5G A;  2BHB A;  5JI6 A;  4IEC A;  3TB5 A;  5FCH A;  4U71 A;  2EVO A;  4IDY A;  2Q93 A;  1O0X A;  4S00 A;  4KM3 A;  1WLR A;  1N51 A;  1B6A A;  4ZWO A;  4PV4 A;  4U6J A;  2GG0 A;  4U6Z A;  4RZY A;  4A6W A;  1QXZ A;  5CDE A;  4EGE A;  2GG5 A;  2B3K A;  1R5H A;  1C21 A;  3IU7 A;  4ZWU A;  2BWU A;  4ZWP A;  2P98 A;  3PKC A;  1PV9 A;  2HOW A;  1KP0 A;  1XNZ A;  4FLI A;  3TAV A;  1QZY A;  4QR8 A;  4IU6 A;  1JAW A;  2BHA A;  3BIT A;  4S01 A;  5CNX A;  1WKM A;  4R60 A;  2Q92 A;  4HXX A;  2GU5 A;  4PNC A;  3IU8 A;  3ROR A;  4IKU A;  4FUK A;  2MAT A;  2EVC A;  1C22 A;  4FLJ A;  4FO8 A;  2GG7 A;  1YW9 A;  2Q95 A;  3MAT A;  2P9A A;  4U6C A;  2BWW A;  2BHD A;  5FCF A;  4FLK A;  2EVM A;  2EA2 A;  3FMQ A;  4S2T P;  3PKB A;  2GG9 A;  1YW8 A;  2GU7 A;  5JFR A;  3L24 A;  3IG4 A;  3PKE A;  2GA2 A;  3FM3 A;  2Q94 A;  2BWX A;  2B3H A;  1W7V A;  1YVM A;  3BIQ A;  3Q6D A;  4U6E A;  3RVA A;  2Q8K A;  1KQ0 A;  4U75 A;  1C23 A;  1CHM A;  3BIP A;  4RGZ 1;  2GZ5 A;  1QXW A;  1B59 A;  1M35 A;  3IU9 A;  2V6C A;  4IF7 A;  3FMR A;  2ADU A;  2OKN A;  4Z7M A;  3CTZ A;  4ZNG A;  2V3Z A;  4U1B A;  3PKD A;  3PKA A;  2EA4 A;  2GU6 A;  4MAT A;  5D6E A;  1C24 A;  4U6W A;  1XGO A;  5CDV A;  5CE6 A;  1WBQ A;  2BN7 A;  2V3X A;  1WL6 A;  1WN1 A;  5CLS A;  3D27 A;  3MX6 A;  1BN5 A;  1BOA A;  2GU4 A;  2IW2 A;  3L7G A;  3CB6 A;  2GG3 A;  1R58 A;  3CB5 A;  2BHC A;  2NQ7 A;  4U76 A;  2GG8 A;  4U69 A;  1YJ3 A;  1MAT A;  1XGN A; 
#chains in the Genus database with same CATH homology
 5CDL A;  2BWY A;  2P99 A;  2BWS A;  4IKT A;  2Q96 A;  2BH3 A;  1WY2 A;  1Y1N A;  2GGB A;  2OAZ A;  1YW7 A;  4IKS A;  3MR1 A;  1C27 A;  2BB7 A;  4A6V A;  4OOK A;  5E5B A;  4FO7 A;  2GTX A;  3S6B A;  1KQ9 A;  4FKC A;  4FLL A;  2G6P A;  1W2M A;  2B3L A;  5D6F A;  2BWV A;  1WL9 A;  2DFI A;  2NQ6 A;  1XGM A;  1A16 A;  4IKR A;  2V3Y A;  4U70 A;  4U73 A;  5CIK A;  2GG2 A;  2BWT A;  4B28 A;  4IPA A;  2ZSG A;  4RZZ A;  4S2R P;  5JHU A;  1QXY A;  2GGC A;  4JUQ A;  1XGS A;  1R5G A;  2BHB A;  5JI6 A;  4IEC A;  3TB5 A;  5FCH A;  4U71 A;  2EVO A;  4IDY A;  2Q93 A;  1O0X A;  4S00 A;  4KM3 A;  1WLR A;  1N51 A;  1B6A A;  4ZWO A;  4PV4 A;  4U6J A;  2GG0 A;  4U6Z A;  4RZY A;  4A6W A;  1QXZ A;  5CDE A;  4EGE A;  2GG5 A;  2B3K A;  1R5H A;  1C21 A;  3IU7 A;  4ZWU A;  2BWU A;  4ZWP A;  2P98 A;  3PKC A;  1PV9 A;  2HOW A;  1KP0 A;  1XNZ A;  4FLI A;  3TAV A;  1QZY A;  4QR8 A;  4IU6 A;  1JAW A;  2BHA A;  3BIT A;  4S01 A;  5CNX A;  1WKM A;  4R60 A;  2Q92 A;  4HXX A;  2GU5 A;  4PNC A;  3IU8 A;  3ROR A;  4IKU A;  4FUK A;  2MAT A;  2EVC A;  1C22 A;  4FLJ A;  4FO8 A;  2GG7 A;  1YW9 A;  2Q95 A;  3MAT A;  2P9A A;  4U6C A;  2BWW A;  2BHD A;  5FCF A;  4FLK A;  2EVM A;  2EA2 A;  3FMQ A;  4S2T P;  3PKB A;  2GG9 A;  1YW8 A;  2GU7 A;  5JFR A;  3L24 A;  3IG4 A;  3PKE A;  2GA2 A;  3FM3 A;  2Q94 A;  2BWX A;  2B3H A;  1W7V A;  1YVM A;  3BIQ A;  3Q6D A;  4U6E A;  3RVA A;  2Q8K A;  1KQ0 A;  4U75 A;  1C23 A;  1CHM A;  3BIP A;  4RGZ 1;  2GZ5 A;  1QXW A;  1B59 A;  1M35 A;  3IU9 A;  2V6C A;  4IF7 A;  3FMR A;  2ADU A;  2OKN A;  4Z7M A;  3CTZ A;  4ZNG A;  2V3Z A;  4U1B A;  3PKD A;  3PKA A;  2EA4 A;  2GU6 A;  4MAT A;  5D6E A;  1C24 A;  4U6W A;  1XGO A;  5CDV A;  5CE6 A;  1WBQ A;  2BN7 A;  2V3X A;  1WL6 A;  1WN1 A;  5CLS A;  3D27 A;  3MX6 A;  1BN5 A;  1BOA A;  2GU4 A;  2IW2 A;  3L7G A;  3CB6 A;  2GG3 A;  1R58 A;  3CB5 A;  2BHC A;  2NQ7 A;  4U76 A;  2GG8 A;  4U69 A;  1YJ3 A;  1MAT A;  1XGN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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