2P9AA

E. coli methionine aminopeptidase dimetalated with inhibitor ye6
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p9aA00
3CB6A 5E5BA 4Z7MA 2OKNA 4FLJA 1C22A 1WKMA 4FLKA 5D6FA 1N51A 1XNZA 1KQ9A 4FLIA 2GTXA 5JHUA 1YW7A 3TAVA 2BWSA 2NQ6A 3IU7A 3RVAA 2GG2A 1XGMA 2GA2A 1XGNA 2NQ7A 2P9AA 2Q93A 3BITA 3BIQA 4IECA 2P99A 3FMRA 1R58A 1A16A 4RZZA 2BWWA 4IKUA 2GGBA 2V3YA 1XGOA 1R5GA 2BHAA 1MATA 4MATA 2EVCA 4U1BA 1BN5A 1WL6A 5JI6A 2BHBA 2V3XA 3CTZA 4U75A 2Q95A 4U69A 5CE6A 1WY2A 2P98A 1QXWA 3L7GA 3PKEA 3Q6DA 1C27A 1KP0A 4RGZ1 3D27A 4PV4A 2DFIA 2G6PA 4U6JA 1QZYA 4FKCA 4FUKA 2BB7A 2GG9A 1BOAA 2V6CA 4ZWUA 4OOKA 5CDEA 2ZSGA 5CDLA 3CB5A 2B3HA 5CNXA 1YW8A 2BHCA 4EGEA 4HXXA 2EVMA 1YW9A 4IDYA 3TB5A 2BWYA 2HOWA 3MX6A 2BWVA 2GG3A 1YVMA 3IU9A 4KM3A 2GG5A 1WLRA 4U6EA 2EA2A 4U70A 5CIKA 3S6BA 1Y1NA 3MR1A 4IU6A 2BHDA 2GU5A 3PKAA 2GU4A 1QXYA 1B6AA 4U73A 2BWXA 4FLLA 1W7VA 4ZNGA 3L24A 4U6WA 1JAWA 2BWUA 1M35A 1O0XA 1B59A 4IPAA 2B3LA 4IF7A 2Q94A 1YJ3A 2GU6A 1WBQA 1W2MA 4S01A 2BH3A 4A6VA 4IKSA 3MATA 4FO7A 2EA4A 2Q92A 3PKBA 1C24A 1C21A 3FM3A 2EVOA 5JFRA 1KQ0A 2MATA 4S00A 4U6ZA 2IW2A 2BN7A 4U71A 4S2TP 5CDVA 4IKTA 4PNCA 3BIPA 1PV9A 4JUQA 4U6CA 4R60A 1WN1A 3PKCA 5FCFA 4ZWOA 5FCHA 2Q96A 2B3KA 4A6WA 5CLSA 2GG0A 2ADUA 4B28A 3IU8A 2GGCA 2V3ZA 1C23A 3PKDA 1XGSA 1QXZA 2GG7A 2GU7A 1WL9A 4ZWPA 4QR8A 5D6EA 2BWTA 2Q8KA 4U76A 4RZYA 4IKRA 3RORA 2GZ5A 3IG4A 1CHMA 4S2RP 1R5HA 2GG8A 2OAZA 4FO8A 3FMQA
chains in the Genus database with same CATH superfamily
3CB6A 5E5BA 4Z7MA 2OKNA 4FLJA 1C22A 1WKMA 4FLKA 5D6FA 1N51A 1XNZA 1KQ9A 4FLIA 2GTXA 5JHUA 1YW7A 3TAVA 2BWSA 2NQ6A 3IU7A 3RVAA 2GG2A 1XGMA 2GA2A 1XGNA 2NQ7A 2P9AA 2Q93A 3BITA 3BIQA 4IECA 2P99A 3FMRA 1R58A 1A16A 4RZZA 2BWWA 4IKUA 2GGBA 2V3YA 1XGOA 1R5GA 2BHAA 1MATA 4MATA 2EVCA 4U1BA 1BN5A 1WL6A 5JI6A 2BHBA 2V3XA 3CTZA 4U75A 2Q95A 4U69A 5CE6A 1WY2A 2P98A 1QXWA 3L7GA 3PKEA 3Q6DA 1C27A 1KP0A 4RGZ1 3D27A 4PV4A 2DFIA 2G6PA 4U6JA 1QZYA 4FKCA 4FUKA 2BB7A 2GG9A 1BOAA 2V6CA 4ZWUA 4OOKA 5CDEA 2ZSGA 5CDLA 3CB5A 2B3HA 5CNXA 1YW8A 2BHCA 4EGEA 4HXXA 2EVMA 1YW9A 4IDYA 3TB5A 2BWYA 2HOWA 3MX6A 2BWVA 2GG3A 1YVMA 3IU9A 4KM3A 2GG5A 1WLRA 4U6EA 2EA2A 4U70A 5CIKA 3S6BA 1Y1NA 3MR1A 4IU6A 2BHDA 2GU5A 3PKAA 2GU4A 1QXYA 1B6AA 4U73A 2BWXA 4FLLA 1W7VA 4ZNGA 3L24A 4U6WA 1JAWA 2BWUA 1M35A 1O0XA 1B59A 4IPAA 2B3LA 4IF7A 2Q94A 1YJ3A 2GU6A 1WBQA 1W2MA 4S01A 2BH3A 4A6VA 4IKSA 3MATA 4FO7A 2EA4A 2Q92A 3PKBA 1C24A 1C21A 3FM3A 2EVOA 5JFRA 1KQ0A 2MATA 4S00A 4U6ZA 2IW2A 2BN7A 4U71A 4S2TP 5CDVA 4IKTA 4PNCA 3BIPA 1PV9A 4JUQA 4U6CA 4R60A 1WN1A 3PKCA 5FCFA 4ZWOA 5FCHA 2Q96A 2B3KA 4A6WA 5CLSA 2GG0A 2ADUA 4B28A 3IU8A 2GGCA 2V3ZA 1C23A 3PKDA 1XGSA 1QXZA 2GG7A 2GU7A 1WL9A 4ZWPA 4QR8A 5D6EA 2BWTA 2Q8KA 4U76A 4RZYA 4IKRA 3RORA 2GZ5A 3IG4A 1CHMA 4S2RP 1R5HA 2GG8A 2OAZA 4FO8A 3FMQA
chains in the Genus database with same CATH topology
3CB6A 5E5BA 4Z7MA 2OKNA 4FLJA 1C22A 1WKMA 4FLKA 5D6FA 1N51A 1XNZA 1KQ9A 4FLIA 2GTXA 5JHUA 1YW7A 3TAVA 2BWSA 2NQ6A 3IU7A 3RVAA 2GG2A 1XGMA 2GA2A 1XGNA 2NQ7A 2P9AA 2Q93A 3BITA 3BIQA 4IECA 2P99A 3FMRA 1R58A 1A16A 4RZZA 2BWWA 4IKUA 2GGBA 2V3YA 1XGOA 1R5GA 2BHAA 1MATA 4MATA 2EVCA 4U1BA 1BN5A 1WL6A 5JI6A 2BHBA 2V3XA 3CTZA 4U75A 2Q95A 4U69A 5CE6A 1WY2A 2P98A 1QXWA 3L7GA 3PKEA 3Q6DA 1C27A 1KP0A 4RGZ1 3D27A 4PV4A 2DFIA 2G6PA 4U6JA 1QZYA 4FKCA 4FUKA 2BB7A 2GG9A 1BOAA 2V6CA 4ZWUA 4OOKA 5CDEA 2ZSGA 5CDLA 3CB5A 2B3HA 5CNXA 1YW8A 2BHCA 4EGEA 4HXXA 2EVMA 1YW9A 4IDYA 3TB5A 2BWYA 2HOWA 3MX6A 2BWVA 2GG3A 1YVMA 3IU9A 4KM3A 2GG5A 1WLRA 4U6EA 2EA2A 4U70A 5CIKA 3S6BA 1Y1NA 3MR1A 4IU6A 2BHDA 2GU5A 3PKAA 2GU4A 1QXYA 1B6AA 4U73A 2BWXA 4FLLA 1W7VA 4ZNGA 3L24A 4U6WA 1JAWA 2BWUA 1M35A 1O0XA 1B59A 4IPAA 2B3LA 4IF7A 2Q94A 1YJ3A 2GU6A 1WBQA 1W2MA 4S01A 2BH3A 4A6VA 4IKSA 3MATA 4FO7A 2EA4A 2Q92A 3PKBA 1C24A 1C21A 3FM3A 2EVOA 5JFRA 1KQ0A 2MATA 4S00A 4U6ZA 2IW2A 2BN7A 4U71A 4S2TP 5CDVA 4IKTA 4PNCA 3BIPA 1PV9A 4JUQA 4U6CA 4R60A 1WN1A 3PKCA 5FCFA 4ZWOA 5FCHA 2Q96A 2B3KA 4A6WA 5CLSA 2GG0A 2ADUA 4B28A 3IU8A 2GGCA 2V3ZA 1C23A 3PKDA 1XGSA 1QXZA 2GG7A 2GU7A 1WL9A 4ZWPA 4QR8A 5D6EA 2BWTA 2Q8KA 4U76A 4RZYA 4IKRA 3RORA 2GZ5A 3IG4A 1CHMA 4S2RP 1R5HA 2GG8A 2OAZA 4FO8A 3FMQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3CB6 A;  5E5B A;  4Z7M A;  2OKN A;  4FLJ A;  1C22 A;  1WKM A;  4FLK A;  5D6F A;  1N51 A;  1XNZ A;  1KQ9 A;  4FLI A;  2GTX A;  5JHU A;  1YW7 A;  3TAV A;  2BWS A;  2NQ6 A;  3IU7 A;  3RVA A;  2GG2 A;  1XGM A;  2GA2 A;  1XGN A;  2NQ7 A;  2P9A A;  2Q93 A;  3BIT A;  3BIQ A;  4IEC A;  2P99 A;  3FMR A;  1R58 A;  1A16 A;  4RZZ A;  2BWW A;  4IKU A;  2GGB A;  2V3Y A;  1XGO A;  1R5G A;  2BHA A;  1MAT A;  4MAT A;  2EVC A;  4U1B A;  1BN5 A;  1WL6 A;  5JI6 A;  2BHB A;  2V3X A;  3CTZ A;  4U75 A;  2Q95 A;  4U69 A;  5CE6 A;  1WY2 A;  2P98 A;  1QXW A;  3L7G A;  3PKE A;  3Q6D A;  1C27 A;  1KP0 A;  4RGZ 1;  3D27 A;  4PV4 A;  2DFI A;  2G6P A;  4U6J A;  1QZY A;  4FKC A;  4FUK A;  2BB7 A;  2GG9 A;  1BOA A;  2V6C A;  4ZWU A;  4OOK A;  5CDE A;  2ZSG A;  5CDL A;  3CB5 A;  2B3H A;  5CNX A;  1YW8 A;  2BHC A;  4EGE A;  4HXX A;  2EVM A;  1YW9 A;  4IDY A;  3TB5 A;  2BWY A;  2HOW A;  3MX6 A;  2BWV A;  2GG3 A;  1YVM A;  3IU9 A;  4KM3 A;  2GG5 A;  1WLR A;  4U6E A;  2EA2 A;  4U70 A;  5CIK A;  3S6B A;  1Y1N A;  3MR1 A;  4IU6 A;  2BHD A;  2GU5 A;  3PKA A;  2GU4 A;  1QXY A;  1B6A A;  4U73 A;  2BWX A;  4FLL A;  1W7V A;  4ZNG A;  3L24 A;  4U6W A;  1JAW A;  2BWU A;  1M35 A;  1O0X A;  1B59 A;  4IPA A;  2B3L A;  4IF7 A;  2Q94 A;  1YJ3 A;  2GU6 A;  1WBQ A;  1W2M A;  4S01 A;  2BH3 A;  4A6V A;  4IKS A;  3MAT A;  4FO7 A;  2EA4 A;  2Q92 A;  3PKB A;  1C24 A;  1C21 A;  3FM3 A;  2EVO A;  5JFR A;  1KQ0 A;  2MAT A;  4S00 A;  4U6Z A;  2IW2 A;  2BN7 A;  4U71 A;  4S2T P;  5CDV A;  4IKT A;  4PNC A;  3BIP A;  1PV9 A;  4JUQ A;  4U6C A;  4R60 A;  1WN1 A;  3PKC A;  5FCF A;  4ZWO A;  5FCH A;  2Q96 A;  2B3K A;  4A6W A;  5CLS A;  2GG0 A;  2ADU A;  4B28 A;  3IU8 A;  2GGC A;  2V3Z A;  1C23 A;  3PKD A;  1XGS A;  1QXZ A;  2GG7 A;  2GU7 A;  1WL9 A;  4ZWP A;  4QR8 A;  5D6E A;  2BWT A;  2Q8K A;  4U76 A;  4RZY A;  4IKR A;  3ROR A;  2GZ5 A;  3IG4 A;  1CHM A;  4S2R P;  1R5H A;  2GG8 A;  2OAZ A;  4FO8 A;  3FMQ A; 
#chains in the Genus database with same CATH topology
 3CB6 A;  5E5B A;  4Z7M A;  2OKN A;  4FLJ A;  1C22 A;  1WKM A;  4FLK A;  5D6F A;  1N51 A;  1XNZ A;  1KQ9 A;  4FLI A;  2GTX A;  5JHU A;  1YW7 A;  3TAV A;  2BWS A;  2NQ6 A;  3IU7 A;  3RVA A;  2GG2 A;  1XGM A;  2GA2 A;  1XGN A;  2NQ7 A;  2P9A A;  2Q93 A;  3BIT A;  3BIQ A;  4IEC A;  2P99 A;  3FMR A;  1R58 A;  1A16 A;  4RZZ A;  2BWW A;  4IKU A;  2GGB A;  2V3Y A;  1XGO A;  1R5G A;  2BHA A;  1MAT A;  4MAT A;  2EVC A;  4U1B A;  1BN5 A;  1WL6 A;  5JI6 A;  2BHB A;  2V3X A;  3CTZ A;  4U75 A;  2Q95 A;  4U69 A;  5CE6 A;  1WY2 A;  2P98 A;  1QXW A;  3L7G A;  3PKE A;  3Q6D A;  1C27 A;  1KP0 A;  4RGZ 1;  3D27 A;  4PV4 A;  2DFI A;  2G6P A;  4U6J A;  1QZY A;  4FKC A;  4FUK A;  2BB7 A;  2GG9 A;  1BOA A;  2V6C A;  4ZWU A;  4OOK A;  5CDE A;  2ZSG A;  5CDL A;  3CB5 A;  2B3H A;  5CNX A;  1YW8 A;  2BHC A;  4EGE A;  4HXX A;  2EVM A;  1YW9 A;  4IDY A;  3TB5 A;  2BWY A;  2HOW A;  3MX6 A;  2BWV A;  2GG3 A;  1YVM A;  3IU9 A;  4KM3 A;  2GG5 A;  1WLR A;  4U6E A;  2EA2 A;  4U70 A;  5CIK A;  3S6B A;  1Y1N A;  3MR1 A;  4IU6 A;  2BHD A;  2GU5 A;  3PKA A;  2GU4 A;  1QXY A;  1B6A A;  4U73 A;  2BWX A;  4FLL A;  1W7V A;  4ZNG A;  3L24 A;  4U6W A;  1JAW A;  2BWU A;  1M35 A;  1O0X A;  1B59 A;  4IPA A;  2B3L A;  4IF7 A;  2Q94 A;  1YJ3 A;  2GU6 A;  1WBQ A;  1W2M A;  4S01 A;  2BH3 A;  4A6V A;  4IKS A;  3MAT A;  4FO7 A;  2EA4 A;  2Q92 A;  3PKB A;  1C24 A;  1C21 A;  3FM3 A;  2EVO A;  5JFR A;  1KQ0 A;  2MAT A;  4S00 A;  4U6Z A;  2IW2 A;  2BN7 A;  4U71 A;  4S2T P;  5CDV A;  4IKT A;  4PNC A;  3BIP A;  1PV9 A;  4JUQ A;  4U6C A;  4R60 A;  1WN1 A;  3PKC A;  5FCF A;  4ZWO A;  5FCH A;  2Q96 A;  2B3K A;  4A6W A;  5CLS A;  2GG0 A;  2ADU A;  4B28 A;  3IU8 A;  2GGC A;  2V3Z A;  1C23 A;  3PKD A;  1XGS A;  1QXZ A;  2GG7 A;  2GU7 A;  1WL9 A;  4ZWP A;  4QR8 A;  5D6E A;  2BWT A;  2Q8K A;  4U76 A;  4RZY A;  4IKR A;  3ROR A;  2GZ5 A;  3IG4 A;  1CHM A;  4S2R P;  1R5H A;  2GG8 A;  2OAZ A;  4FO8 A;  3FMQ A; 
#chains in the Genus database with same CATH homology
 3CB6 A;  5E5B A;  4Z7M A;  2OKN A;  4FLJ A;  1C22 A;  1WKM A;  4FLK A;  5D6F A;  1N51 A;  1XNZ A;  1KQ9 A;  4FLI A;  2GTX A;  5JHU A;  1YW7 A;  3TAV A;  2BWS A;  2NQ6 A;  3IU7 A;  3RVA A;  2GG2 A;  1XGM A;  2GA2 A;  1XGN A;  2NQ7 A;  2P9A A;  2Q93 A;  3BIT A;  3BIQ A;  4IEC A;  2P99 A;  3FMR A;  1R58 A;  1A16 A;  4RZZ A;  2BWW A;  4IKU A;  2GGB A;  2V3Y A;  1XGO A;  1R5G A;  2BHA A;  1MAT A;  4MAT A;  2EVC A;  4U1B A;  1BN5 A;  1WL6 A;  5JI6 A;  2BHB A;  2V3X A;  3CTZ A;  4U75 A;  2Q95 A;  4U69 A;  5CE6 A;  1WY2 A;  2P98 A;  1QXW A;  3L7G A;  3PKE A;  3Q6D A;  1C27 A;  1KP0 A;  4RGZ 1;  3D27 A;  4PV4 A;  2DFI A;  2G6P A;  4U6J A;  1QZY A;  4FKC A;  4FUK A;  2BB7 A;  2GG9 A;  1BOA A;  2V6C A;  4ZWU A;  4OOK A;  5CDE A;  2ZSG A;  5CDL A;  3CB5 A;  2B3H A;  5CNX A;  1YW8 A;  2BHC A;  4EGE A;  4HXX A;  2EVM A;  1YW9 A;  4IDY A;  3TB5 A;  2BWY A;  2HOW A;  3MX6 A;  2BWV A;  2GG3 A;  1YVM A;  3IU9 A;  4KM3 A;  2GG5 A;  1WLR A;  4U6E A;  2EA2 A;  4U70 A;  5CIK A;  3S6B A;  1Y1N A;  3MR1 A;  4IU6 A;  2BHD A;  2GU5 A;  3PKA A;  2GU4 A;  1QXY A;  1B6A A;  4U73 A;  2BWX A;  4FLL A;  1W7V A;  4ZNG A;  3L24 A;  4U6W A;  1JAW A;  2BWU A;  1M35 A;  1O0X A;  1B59 A;  4IPA A;  2B3L A;  4IF7 A;  2Q94 A;  1YJ3 A;  2GU6 A;  1WBQ A;  1W2M A;  4S01 A;  2BH3 A;  4A6V A;  4IKS A;  3MAT A;  4FO7 A;  2EA4 A;  2Q92 A;  3PKB A;  1C24 A;  1C21 A;  3FM3 A;  2EVO A;  5JFR A;  1KQ0 A;  2MAT A;  4S00 A;  4U6Z A;  2IW2 A;  2BN7 A;  4U71 A;  4S2T P;  5CDV A;  4IKT A;  4PNC A;  3BIP A;  1PV9 A;  4JUQ A;  4U6C A;  4R60 A;  1WN1 A;  3PKC A;  5FCF A;  4ZWO A;  5FCH A;  2Q96 A;  2B3K A;  4A6W A;  5CLS A;  2GG0 A;  2ADU A;  4B28 A;  3IU8 A;  2GGC A;  2V3Z A;  1C23 A;  3PKD A;  1XGS A;  1QXZ A;  2GG7 A;  2GU7 A;  1WL9 A;  4ZWP A;  4QR8 A;  5D6E A;  2BWT A;  2Q8K A;  4U76 A;  4RZY A;  4IKR A;  3ROR A;  2GZ5 A;  3IG4 A;  1CHM A;  4S2R P;  1R5H A;  2GG8 A;  2OAZ A;  4FO8 A;  3FMQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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