2Q96A

E. coli methionine aminopeptidase mn-form with inhibitor a18
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 82
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2q96A00
3TB5A 3S6BA 1WBQA 3D27A 5JFRA 4A6WA 2BWYA 1WY2A 3PKDA 3L24A 2GTXA 2BWVA 2GGBA 1WL6A 3Q6DA 2B3KA 1CHMA 2V3ZA 4JUQA 4FKCA 2GU4A 5CDLA 1W7VA 2GU7A 2NQ7A 1KQ9A 1XGSA 3IG4A 4IF7A 4U75A 5FCHA 2B3HA 4FLLA 2V6CA 2GG2A 1KP0A 1PV9A 2IW2A 2BHCA 1BN5A 2MATA 2GG7A 4U70A 3IU8A 2BN7A 3BIQA 4U71A 4B28A 2GZ5A 1YJ3A 2OKNA 2DFIA 2Q8KA 1QZYA 2BB7A 2Q92A 2P9AA 2BHAA 1XGOA 2G6PA 5CNXA 1C27A 4U6ZA 2BH3A 3RVAA 3CB5A 1XNZA 4FLIA 3BITA 4R60A 4QR8A 4PV4A 4KM3A 2BWTA 2BWWA 4RGZ1 4MATA 4IPAA 1C24A 4ZWOA 4U6CA 1A16A 1MATA 4S2RP 1WKMA 4FLJA 4IU6A 1XGNA 5CIKA 2GGCA 4RZYA 3TAVA 1WN1A 1B6AA 2GG5A 4IKUA 1WL9A 4HXXA 4A6VA 4ZWUA 4U6EA 4S2TP 3MR1A 2GA2A 3PKCA 4U73A 1B59A 2ADUA 1O0XA 2P98A 1C21A 2BHDA 2P99A 4U76A 1BOAA 2GG0A 1QXZA 2V3XA 2NQ6A 3CB6A 4IKTA 1W2MA 2V3YA 3BIPA 2OAZA 3L7GA 3RORA 4EGEA 3CTZA 2EVCA 4U1BA 4U6JA 1YW9A 2B3LA 4IKSA 4FLKA 4FUKA 2BWUA 4IECA 4S00A 5E5BA 2EVMA 3PKBA 2BHBA 3FM3A 2Q96A 5D6FA 3IU9A 2BWSA 1WLRA 4FO8A 1Y1NA 5CDVA 1JAWA 1KQ0A 1R58A 5FCFA 1YVMA 2EA2A 2GG9A 3PKAA 2EVOA 2GU6A 4IKRA 5JI6A 4U6WA 3PKEA 2BWXA 1YW8A 5D6EA 4Z7MA 3FMRA 2Q93A 2GG8A 1QXWA 2GU5A 4S01A 2HOWA 2ZSGA 4RZZA 1XGMA 5CLSA 5CDEA 3FMQA 1N51A 4FO7A 2Q94A 4OOKA 4IDYA 4ZWPA 2GG3A 4PNCA 3MX6A 1R5GA 1M35A 1R5HA 2Q95A 2EA4A 3MATA 5CE6A 3IU7A 1C23A 1YW7A 5JHUA 1QXYA 4U69A 1C22A 4ZNGA
chains in the Genus database with same CATH superfamily
3TB5A 3S6BA 1WBQA 3D27A 5JFRA 4A6WA 2BWYA 1WY2A 3PKDA 3L24A 2GTXA 2BWVA 2GGBA 1WL6A 3Q6DA 2B3KA 1CHMA 2V3ZA 4JUQA 4FKCA 2GU4A 5CDLA 1W7VA 2GU7A 2NQ7A 1KQ9A 1XGSA 3IG4A 4IF7A 4U75A 5FCHA 2B3HA 4FLLA 2V6CA 2GG2A 1KP0A 1PV9A 2IW2A 2BHCA 1BN5A 2MATA 2GG7A 4U70A 3IU8A 2BN7A 3BIQA 4U71A 4B28A 2GZ5A 1YJ3A 2OKNA 2DFIA 2Q8KA 1QZYA 2BB7A 2Q92A 2P9AA 2BHAA 1XGOA 2G6PA 5CNXA 1C27A 4U6ZA 2BH3A 3RVAA 3CB5A 1XNZA 4FLIA 3BITA 4R60A 4QR8A 4PV4A 4KM3A 2BWTA 2BWWA 4RGZ1 4MATA 4IPAA 1C24A 4ZWOA 4U6CA 1A16A 1MATA 4S2RP 1WKMA 4FLJA 4IU6A 1XGNA 5CIKA 2GGCA 4RZYA 3TAVA 1WN1A 1B6AA 2GG5A 4IKUA 1WL9A 4HXXA 4A6VA 4ZWUA 4U6EA 4S2TP 3MR1A 2GA2A 3PKCA 4U73A 1B59A 2ADUA 1O0XA 2P98A 1C21A 2BHDA 2P99A 4U76A 1BOAA 2GG0A 1QXZA 2V3XA 2NQ6A 3CB6A 4IKTA 1W2MA 2V3YA 3BIPA 2OAZA 3L7GA 3RORA 4EGEA 3CTZA 2EVCA 4U1BA 4U6JA 1YW9A 2B3LA 4IKSA 4FLKA 4FUKA 2BWUA 4IECA 4S00A 5E5BA 2EVMA 3PKBA 2BHBA 3FM3A 2Q96A 5D6FA 3IU9A 2BWSA 1WLRA 4FO8A 1Y1NA 5CDVA 1JAWA 1KQ0A 1R58A 5FCFA 1YVMA 2EA2A 2GG9A 3PKAA 2EVOA 2GU6A 4IKRA 5JI6A 4U6WA 3PKEA 2BWXA 1YW8A 5D6EA 4Z7MA 3FMRA 2Q93A 2GG8A 1QXWA 2GU5A 4S01A 2HOWA 2ZSGA 4RZZA 1XGMA 5CLSA 5CDEA 3FMQA 1N51A 4FO7A 2Q94A 4OOKA 4IDYA 4ZWPA 2GG3A 4PNCA 3MX6A 1R5GA 1M35A 1R5HA 2Q95A 2EA4A 3MATA 5CE6A 3IU7A 1C23A 1YW7A 5JHUA 1QXYA 4U69A 1C22A 4ZNGA
chains in the Genus database with same CATH topology
3TB5A 3S6BA 1WBQA 3D27A 5JFRA 4A6WA 2BWYA 1WY2A 3PKDA 3L24A 2GTXA 2BWVA 2GGBA 1WL6A 3Q6DA 2B3KA 1CHMA 2V3ZA 4JUQA 4FKCA 2GU4A 5CDLA 1W7VA 2GU7A 2NQ7A 1KQ9A 1XGSA 3IG4A 4IF7A 4U75A 5FCHA 2B3HA 4FLLA 2V6CA 2GG2A 1KP0A 1PV9A 2IW2A 2BHCA 1BN5A 2MATA 2GG7A 4U70A 3IU8A 2BN7A 3BIQA 4U71A 4B28A 2GZ5A 1YJ3A 2OKNA 2DFIA 2Q8KA 1QZYA 2BB7A 2Q92A 2P9AA 2BHAA 1XGOA 2G6PA 5CNXA 1C27A 4U6ZA 2BH3A 3RVAA 3CB5A 1XNZA 4FLIA 3BITA 4R60A 4QR8A 4PV4A 4KM3A 2BWTA 2BWWA 4RGZ1 4MATA 4IPAA 1C24A 4ZWOA 4U6CA 1A16A 1MATA 4S2RP 1WKMA 4FLJA 4IU6A 1XGNA 5CIKA 2GGCA 4RZYA 3TAVA 1WN1A 1B6AA 2GG5A 4IKUA 1WL9A 4HXXA 4A6VA 4ZWUA 4U6EA 4S2TP 3MR1A 2GA2A 3PKCA 4U73A 1B59A 2ADUA 1O0XA 2P98A 1C21A 2BHDA 2P99A 4U76A 1BOAA 2GG0A 1QXZA 2V3XA 2NQ6A 3CB6A 4IKTA 1W2MA 2V3YA 3BIPA 2OAZA 3L7GA 3RORA 4EGEA 3CTZA 2EVCA 4U1BA 4U6JA 1YW9A 2B3LA 4IKSA 4FLKA 4FUKA 2BWUA 4IECA 4S00A 5E5BA 2EVMA 3PKBA 2BHBA 3FM3A 2Q96A 5D6FA 3IU9A 2BWSA 1WLRA 4FO8A 1Y1NA 5CDVA 1JAWA 1KQ0A 1R58A 5FCFA 1YVMA 2EA2A 2GG9A 3PKAA 2EVOA 2GU6A 4IKRA 5JI6A 4U6WA 3PKEA 2BWXA 1YW8A 5D6EA 4Z7MA 3FMRA 2Q93A 2GG8A 1QXWA 2GU5A 4S01A 2HOWA 2ZSGA 4RZZA 1XGMA 5CLSA 5CDEA 3FMQA 1N51A 4FO7A 2Q94A 4OOKA 4IDYA 4ZWPA 2GG3A 4PNCA 3MX6A 1R5GA 1M35A 1R5HA 2Q95A 2EA4A 3MATA 5CE6A 3IU7A 1C23A 1YW7A 5JHUA 1QXYA 4U69A 1C22A 4ZNGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TB5 A;  3S6B A;  1WBQ A;  3D27 A;  5JFR A;  4A6W A;  2BWY A;  1WY2 A;  3PKD A;  3L24 A;  2GTX A;  2BWV A;  2GGB A;  1WL6 A;  3Q6D A;  2B3K A;  1CHM A;  2V3Z A;  4JUQ A;  4FKC A;  2GU4 A;  5CDL A;  1W7V A;  2GU7 A;  2NQ7 A;  1KQ9 A;  1XGS A;  3IG4 A;  4IF7 A;  4U75 A;  5FCH A;  2B3H A;  4FLL A;  2V6C A;  2GG2 A;  1KP0 A;  1PV9 A;  2IW2 A;  2BHC A;  1BN5 A;  2MAT A;  2GG7 A;  4U70 A;  3IU8 A;  2BN7 A;  3BIQ A;  4U71 A;  4B28 A;  2GZ5 A;  1YJ3 A;  2OKN A;  2DFI A;  2Q8K A;  1QZY A;  2BB7 A;  2Q92 A;  2P9A A;  2BHA A;  1XGO A;  2G6P A;  5CNX A;  1C27 A;  4U6Z A;  2BH3 A;  3RVA A;  3CB5 A;  1XNZ A;  4FLI A;  3BIT A;  4R60 A;  4QR8 A;  4PV4 A;  4KM3 A;  2BWT A;  2BWW A;  4RGZ 1;  4MAT A;  4IPA A;  1C24 A;  4ZWO A;  4U6C A;  1A16 A;  1MAT A;  4S2R P;  1WKM A;  4FLJ A;  4IU6 A;  1XGN A;  5CIK A;  2GGC A;  4RZY A;  3TAV A;  1WN1 A;  1B6A A;  2GG5 A;  4IKU A;  1WL9 A;  4HXX A;  4A6V A;  4ZWU A;  4U6E A;  4S2T P;  3MR1 A;  2GA2 A;  3PKC A;  4U73 A;  1B59 A;  2ADU A;  1O0X A;  2P98 A;  1C21 A;  2BHD A;  2P99 A;  4U76 A;  1BOA A;  2GG0 A;  1QXZ A;  2V3X A;  2NQ6 A;  3CB6 A;  4IKT A;  1W2M A;  2V3Y A;  3BIP A;  2OAZ A;  3L7G A;  3ROR A;  4EGE A;  3CTZ A;  2EVC A;  4U1B A;  4U6J A;  1YW9 A;  2B3L A;  4IKS A;  4FLK A;  4FUK A;  2BWU A;  4IEC A;  4S00 A;  5E5B A;  2EVM A;  3PKB A;  2BHB A;  3FM3 A;  2Q96 A;  5D6F A;  3IU9 A;  2BWS A;  1WLR A;  4FO8 A;  1Y1N A;  5CDV A;  1JAW A;  1KQ0 A;  1R58 A;  5FCF A;  1YVM A;  2EA2 A;  2GG9 A;  3PKA A;  2EVO A;  2GU6 A;  4IKR A;  5JI6 A;  4U6W A;  3PKE A;  2BWX A;  1YW8 A;  5D6E A;  4Z7M A;  3FMR A;  2Q93 A;  2GG8 A;  1QXW A;  2GU5 A;  4S01 A;  2HOW A;  2ZSG A;  4RZZ A;  1XGM A;  5CLS A;  5CDE A;  3FMQ A;  1N51 A;  4FO7 A;  2Q94 A;  4OOK A;  4IDY A;  4ZWP A;  2GG3 A;  4PNC A;  3MX6 A;  1R5G A;  1M35 A;  1R5H A;  2Q95 A;  2EA4 A;  3MAT A;  5CE6 A;  3IU7 A;  1C23 A;  1YW7 A;  5JHU A;  1QXY A;  4U69 A;  1C22 A;  4ZNG A; 
#chains in the Genus database with same CATH topology
 3TB5 A;  3S6B A;  1WBQ A;  3D27 A;  5JFR A;  4A6W A;  2BWY A;  1WY2 A;  3PKD A;  3L24 A;  2GTX A;  2BWV A;  2GGB A;  1WL6 A;  3Q6D A;  2B3K A;  1CHM A;  2V3Z A;  4JUQ A;  4FKC A;  2GU4 A;  5CDL A;  1W7V A;  2GU7 A;  2NQ7 A;  1KQ9 A;  1XGS A;  3IG4 A;  4IF7 A;  4U75 A;  5FCH A;  2B3H A;  4FLL A;  2V6C A;  2GG2 A;  1KP0 A;  1PV9 A;  2IW2 A;  2BHC A;  1BN5 A;  2MAT A;  2GG7 A;  4U70 A;  3IU8 A;  2BN7 A;  3BIQ A;  4U71 A;  4B28 A;  2GZ5 A;  1YJ3 A;  2OKN A;  2DFI A;  2Q8K A;  1QZY A;  2BB7 A;  2Q92 A;  2P9A A;  2BHA A;  1XGO A;  2G6P A;  5CNX A;  1C27 A;  4U6Z A;  2BH3 A;  3RVA A;  3CB5 A;  1XNZ A;  4FLI A;  3BIT A;  4R60 A;  4QR8 A;  4PV4 A;  4KM3 A;  2BWT A;  2BWW A;  4RGZ 1;  4MAT A;  4IPA A;  1C24 A;  4ZWO A;  4U6C A;  1A16 A;  1MAT A;  4S2R P;  1WKM A;  4FLJ A;  4IU6 A;  1XGN A;  5CIK A;  2GGC A;  4RZY A;  3TAV A;  1WN1 A;  1B6A A;  2GG5 A;  4IKU A;  1WL9 A;  4HXX A;  4A6V A;  4ZWU A;  4U6E A;  4S2T P;  3MR1 A;  2GA2 A;  3PKC A;  4U73 A;  1B59 A;  2ADU A;  1O0X A;  2P98 A;  1C21 A;  2BHD A;  2P99 A;  4U76 A;  1BOA A;  2GG0 A;  1QXZ A;  2V3X A;  2NQ6 A;  3CB6 A;  4IKT A;  1W2M A;  2V3Y A;  3BIP A;  2OAZ A;  3L7G A;  3ROR A;  4EGE A;  3CTZ A;  2EVC A;  4U1B A;  4U6J A;  1YW9 A;  2B3L A;  4IKS A;  4FLK A;  4FUK A;  2BWU A;  4IEC A;  4S00 A;  5E5B A;  2EVM A;  3PKB A;  2BHB A;  3FM3 A;  2Q96 A;  5D6F A;  3IU9 A;  2BWS A;  1WLR A;  4FO8 A;  1Y1N A;  5CDV A;  1JAW A;  1KQ0 A;  1R58 A;  5FCF A;  1YVM A;  2EA2 A;  2GG9 A;  3PKA A;  2EVO A;  2GU6 A;  4IKR A;  5JI6 A;  4U6W A;  3PKE A;  2BWX A;  1YW8 A;  5D6E A;  4Z7M A;  3FMR A;  2Q93 A;  2GG8 A;  1QXW A;  2GU5 A;  4S01 A;  2HOW A;  2ZSG A;  4RZZ A;  1XGM A;  5CLS A;  5CDE A;  3FMQ A;  1N51 A;  4FO7 A;  2Q94 A;  4OOK A;  4IDY A;  4ZWP A;  2GG3 A;  4PNC A;  3MX6 A;  1R5G A;  1M35 A;  1R5H A;  2Q95 A;  2EA4 A;  3MAT A;  5CE6 A;  3IU7 A;  1C23 A;  1YW7 A;  5JHU A;  1QXY A;  4U69 A;  1C22 A;  4ZNG A; 
#chains in the Genus database with same CATH homology
 3TB5 A;  3S6B A;  1WBQ A;  3D27 A;  5JFR A;  4A6W A;  2BWY A;  1WY2 A;  3PKD A;  3L24 A;  2GTX A;  2BWV A;  2GGB A;  1WL6 A;  3Q6D A;  2B3K A;  1CHM A;  2V3Z A;  4JUQ A;  4FKC A;  2GU4 A;  5CDL A;  1W7V A;  2GU7 A;  2NQ7 A;  1KQ9 A;  1XGS A;  3IG4 A;  4IF7 A;  4U75 A;  5FCH A;  2B3H A;  4FLL A;  2V6C A;  2GG2 A;  1KP0 A;  1PV9 A;  2IW2 A;  2BHC A;  1BN5 A;  2MAT A;  2GG7 A;  4U70 A;  3IU8 A;  2BN7 A;  3BIQ A;  4U71 A;  4B28 A;  2GZ5 A;  1YJ3 A;  2OKN A;  2DFI A;  2Q8K A;  1QZY A;  2BB7 A;  2Q92 A;  2P9A A;  2BHA A;  1XGO A;  2G6P A;  5CNX A;  1C27 A;  4U6Z A;  2BH3 A;  3RVA A;  3CB5 A;  1XNZ A;  4FLI A;  3BIT A;  4R60 A;  4QR8 A;  4PV4 A;  4KM3 A;  2BWT A;  2BWW A;  4RGZ 1;  4MAT A;  4IPA A;  1C24 A;  4ZWO A;  4U6C A;  1A16 A;  1MAT A;  4S2R P;  1WKM A;  4FLJ A;  4IU6 A;  1XGN A;  5CIK A;  2GGC A;  4RZY A;  3TAV A;  1WN1 A;  1B6A A;  2GG5 A;  4IKU A;  1WL9 A;  4HXX A;  4A6V A;  4ZWU A;  4U6E A;  4S2T P;  3MR1 A;  2GA2 A;  3PKC A;  4U73 A;  1B59 A;  2ADU A;  1O0X A;  2P98 A;  1C21 A;  2BHD A;  2P99 A;  4U76 A;  1BOA A;  2GG0 A;  1QXZ A;  2V3X A;  2NQ6 A;  3CB6 A;  4IKT A;  1W2M A;  2V3Y A;  3BIP A;  2OAZ A;  3L7G A;  3ROR A;  4EGE A;  3CTZ A;  2EVC A;  4U1B A;  4U6J A;  1YW9 A;  2B3L A;  4IKS A;  4FLK A;  4FUK A;  2BWU A;  4IEC A;  4S00 A;  5E5B A;  2EVM A;  3PKB A;  2BHB A;  3FM3 A;  2Q96 A;  5D6F A;  3IU9 A;  2BWS A;  1WLR A;  4FO8 A;  1Y1N A;  5CDV A;  1JAW A;  1KQ0 A;  1R58 A;  5FCF A;  1YVM A;  2EA2 A;  2GG9 A;  3PKA A;  2EVO A;  2GU6 A;  4IKR A;  5JI6 A;  4U6W A;  3PKE A;  2BWX A;  1YW8 A;  5D6E A;  4Z7M A;  3FMR A;  2Q93 A;  2GG8 A;  1QXW A;  2GU5 A;  4S01 A;  2HOW A;  2ZSG A;  4RZZ A;  1XGM A;  5CLS A;  5CDE A;  3FMQ A;  1N51 A;  4FO7 A;  2Q94 A;  4OOK A;  4IDY A;  4ZWP A;  2GG3 A;  4PNC A;  3MX6 A;  1R5G A;  1M35 A;  1R5H A;  2Q95 A;  2EA4 A;  3MAT A;  5CE6 A;  3IU7 A;  1C23 A;  1YW7 A;  5JHU A;  1QXY A;  4U69 A;  1C22 A;  4ZNG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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