2VH4A

Structure of a loop c-sheet serpin polymer
Total Genus 115
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
115
sequence length
380
structure length
380
Chain Sequence
DRIKANPVSEKNIDEKFIYNTADFSIELFKNSIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALGKDISIEDLNKYLYTYMKKLPNEEKSKLTIANSIWFKENDFMPSKDFLQIIADYYKADIFKAAFDSSTVSDINNWVKSKTNGMIDKILNKIDPEDVMYLINAVAFDAEWETVYEKASVHEDIFTDVYGNRQKVEFMNSEENLYIEEENAIGFVKPYAKNHYSFVAILPDENISVNEYIKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFSKLGKSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNRPFIFAIIDNSTNLPIFIGTVLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Structural Basis for Loop C-Sheet Polymerization in Serpins.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Thermoanaerobacter tengcongensis
molecule keywords TENGPIN
total genus 115
structure length 380
sequence length 380
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-11-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00079 Serpin Serpin (serine protease inhibitor)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.39.10 Mainly Beta Roll Alpha-1-antitrypsin; domain 1 Alpha-1-antitrypsin, domain 1 2vh4A02
3.30.497.10 Alpha Beta 2-Layer Sandwich Antithrombin; Chain I, domain 2 Antithrombin, subunit I, domain 2 2vh4A01
2DUTA 1ATHA 4CAAA 4BB2A 1SEKA 3CWLA 1LJ5A 1QLPA 1C5GA 1DZHL 4AJTA 3DLWA 1HP7A 3DRMA 2WXWA 3NE4A 2WXZA 1LK6I 1DZHI 4G8OA 1E05I 4C41A 2GD4C 3CWMA 4AU3B 5CDZA 8APIA 1TB6I 3FGQA 4ZK0A 1JVQI 1PSIA 2D26A 4RO9A 4AQHA 1ATTA 4IC0A 3NDDA 1T1FA 2QUGA 4DY0A 5INWA 2ZNHA 2BEHL 1A7CA 1DVNA 1QMNA 2VDXA 2ARRA 1OVAC 4GA7A 5CE0A 1DB2A 2H4PA 1AS4A 4Y40A 4ZK3A 2WXXA 2BEHI 1SNGA 1HLEA 1OVAA 2WXZC 1E04I 1B3KA 2XN3A 4YIAA 1DVMA 1NQ9I 4P0FA 4AU4A 1C8OA 3H5CA 1ATUA 2CEOA 1IMVA 3CAAA 4AJUA 2V95A 1E03I 1IZ2A 4ROAA 4AU3A 3DRUA 3B9FI 3NDFA 4P0OA 3ZHAA 2ARQA 2XN7A 4IF8A 2PEFA 1YXAA 1QMBA 2OL2A 3OZQA 1BR8I 1OPHA 3CVMA 2WXYC 1OC0A 2XN6A 3EVJI 2PEEA 4R9IA 4DY7C 2B5TI 3LW2A 1BY7A 3KCGI 4ROBA 3NDAA 4Y3KA 2RIVA 2VH4A 1M93B 2ZV6A 5IO1A 1ANTI 1UHGA 1XQJA 2ACHA 3Q03A 2B4XI 2HIJL 4RSQA 9APIA 4EB1I 2H4RA 2H4QA 2OAYA 1JTIA 2ANTI 4AU2A 4G8RA 2WY1A 1JMJA 2HIJI 1OVAB 4DTEA 1WZ9A 4KDSA 3EOXA 1JMOA 4AFXA 1F0CA 3R4LA 2VDYA 3UT3A 1K9OI 2XN5A 2RIWA 3LE2A 3F5NA 3DY0A 1JRRA 1XU8A 1EZXA 3Q02A 5HGCA 1JJOC 3F02A 5BRRI 2B4XL 1LQ8A 5EI0A 1R1LI 4X30A 4EB1L 5CDXA 4C49A 1OO8A 1OYHL 1KCTA 7APIA 3PZFA 2WY0C 1DZGL 2HI9A 3VVJA 1AZXI 9PAIA 5C98A 1MTPA 4PYWA 1OYHI 2R9YA 3STOA 1XQGA 3T1PA 3F1SA 1SR5A 3PB1I 1DZGI 1D5SA
chains in the Genus database with same CATH superfamily
2DUTA 1ATHA 4CAAA 4BB2A 1SEKA 3CWLA 1LJ5A 1QLPA 1C5GA 1DZHL 4AJTA 3DLWA 1HP7A 3DRMA 2WXWA 3NE4A 2WXZA 1LK6I 1DZHI 4G8OA 1E05I 4C41A 2GD4C 3CWMA 4AU3B 5CDZA 8APIA 1TB6I 3FGQA 4ZK0A 1JVQI 1PSIA 2D26A 4RO9A 4AQHA 1ATTA 4IC0A 3NDDA 1T1FA 2QUGA 4DY0A 5INWA 2ZNHA 2BEHL 1A7CA 1DVNA 1QMNA 2VDXA 2ARRA 1OVAC 4GA7A 5CE0A 1DB2A 2H4PA 1AS4A 4Y40A 4ZK3A 2WXXA 2BEHI 1SNGA 1HLEA 1OVAA 2WXZC 1E04I 1B3KA 2XN3A 4YIAA 1DVMA 1NQ9I 4P0FA 4AU4A 1C8OA 3H5CA 1ATUA 2CEOA 1IMVA 3CAAA 4AJUA 2V95A 1E03I 1IZ2A 4ROAA 4AU3A 3DRUA 3B9FI 3NDFA 4P0OA 3ZHAA 2ARQA 2XN7A 4IF8A 2PEFA 1YXAA 1QMBA 2OL2A 3OZQA 1BR8I 1OPHA 3CVMA 2WXYC 1OC0A 2XN6A 3EVJI 2PEEA 4R9IA 4DY7C 2B5TI 3LW2A 1BY7A 3KCGI 4ROBA 3NDAA 4Y3KA 2RIVA 2VH4A 1M93B 2ZV6A 5IO1A 1ANTI 1UHGA 1XQJA 2ACHA 3Q03A 2B4XI 2HIJL 4RSQA 9APIA 4EB1I 2H4RA 2H4QA 2OAYA 1JTIA 2ANTI 4AU2A 4G8RA 2WY1A 1JMJA 2HIJI 1OVAB 4DTEA 1WZ9A 4KDSA 3EOXA 1JMOA 4AFXA 1F0CA 3R4LA 2VDYA 3UT3A 1K9OI 2XN5A 2RIWA 3LE2A 3F5NA 3DY0A 1JRRA 1XU8A 1EZXA 3Q02A 5HGCA 1JJOC 3F02A 5BRRI 2B4XL 1LQ8A 5EI0A 1R1LI 4X30A 4EB1L 5CDXA 4C49A 1OO8A 1OYHL 1KCTA 7APIA 3PZFA 2WY0C 1DZGL 2HI9A 3VVJA 1AZXI 9PAIA 5C98A 1MTPA 4PYWA 1OYHI 2R9YA 3STOA 1XQGA 3T1PA 3F1SA 1SR5A 3PB1I 1DZGI 1D5SA
chains in the Genus database with same CATH topology
2DUTA 1ATHA 4CAAA 4BB2A 1SEKA 3CWLA 1LJ5A 1QLPA 1C5GA 1DZHL 4AJTA 3DLWA 1HP7A 3DRMA 2WXWA 3NE4A 2WXZA 1LK6I 1DZHI 4G8OA 1E05I 4C41A 2GD4C 3CWMA 4AU3B 5CDZA 8APIA 1TB6I 3FGQA 4ZK0A 1JVQI 1PSIA 2D26A 4RO9A 4AQHA 1ATTA 4IC0A 3NDDA 1T1FA 2QUGA 4DY0A 5INWA 2ZNHA 2BEHL 1A7CA 1DVNA 1QMNA 2VDXA 2ARRA 1OVAC 4GA7A 5CE0A 1DB2A 2H4PA 1AS4A 4Y40A 4ZK3A 2WXXA 2BEHI 1SNGA 1HLEA 1OVAA 2WXZC 1E04I 1B3KA 2XN3A 4YIAA 1DVMA 1NQ9I 4P0FA 4AU4A 1C8OA 3H5CA 1ATUA 2CEOA 1IMVA 3CAAA 4AJUA 2V95A 1E03I 1IZ2A 4ROAA 4AU3A 3DRUA 3B9FI 3NDFA 4P0OA 3ZHAA 2ARQA 2XN7A 4IF8A 2PEFA 1YXAA 1QMBA 2OL2A 3OZQA 1BR8I 1OPHA 3CVMA 2WXYC 1OC0A 2XN6A 3EVJI 2PEEA 4R9IA 4DY7C 2B5TI 3LW2A 1BY7A 3KCGI 4ROBA 3NDAA 4Y3KA 2RIVA 2VH4A 1M93B 2ZV6A 5IO1A 1ANTI 1UHGA 1XQJA 2ACHA 3Q03A 2B4XI 2HIJL 4RSQA 9APIA 4EB1I 2H4RA 2H4QA 2OAYA 1JTIA 2ANTI 4AU2A 4G8RA 2WY1A 1JMJA 2HIJI 1OVAB 4DTEA 1WZ9A 4KDSA 3EOXA 1JMOA 4AFXA 1F0CA 3R4LA 2VDYA 3UT3A 1K9OI 2XN5A 2RIWA 3LE2A 3F5NA 3DY0A 1JRRA 1XU8A 1EZXA 3Q02A 5HGCA 1JJOC 3F02A 5BRRI 2B4XL 1LQ8A 5EI0A 1R1LI 4X30A 4EB1L 5CDXA 4C49A 1OO8A 1OYHL 1KCTA 7APIA 3PZFA 2WY0C 1DZGL 2HI9A 3VVJA 1AZXI 9PAIA 5C98A 1MTPA 4PYWA 1OYHI 2R9YA 3STOA 1XQGA 3T1PA 3F1SA 1SR5A 3PB1I 1DZGI 1D5SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DUT A;  1ATH A;  4CAA A;  4BB2 A;  1SEK A;  3CWL A;  1LJ5 A;  1QLP A;  1C5G A;  1DZH L;  4AJT A;  3DLW A;  1HP7 A;  3DRM A;  2WXW A;  3NE4 A;  2WXZ A;  1LK6 I;  1DZH I;  4G8O A;  1E05 I;  4C41 A;  2GD4 C;  3CWM A;  4AU3 B;  5CDZ A;  8API A;  1TB6 I;  3FGQ A;  4ZK0 A;  1JVQ I;  1PSI A;  2D26 A;  4RO9 A;  4AQH A;  1ATT A;  4IC0 A;  3NDD A;  1T1F A;  2QUG A;  4DY0 A;  5INW A;  2ZNH A;  2BEH L;  1A7C A;  1DVN A;  1QMN A;  2VDX A;  2ARR A;  1OVA C;  4GA7 A;  5CE0 A;  1DB2 A;  2H4P A;  1AS4 A;  4Y40 A;  4ZK3 A;  2WXX A;  2BEH I;  1SNG A;  1HLE A;  1OVA A;  2WXZ C;  1E04 I;  1B3K A;  2XN3 A;  4YIA A;  1DVM A;  1NQ9 I;  4P0F A;  4AU4 A;  1C8O A;  3H5C A;  1ATU A;  2CEO A;  1IMV A;  3CAA A;  4AJU A;  2V95 A;  1E03 I;  1IZ2 A;  4ROA A;  4AU3 A;  3DRU A;  3B9F I;  3NDF A;  4P0O A;  3ZHA A;  2ARQ A;  2XN7 A;  4IF8 A;  2PEF A;  1YXA A;  1QMB A;  2OL2 A;  3OZQ A;  1BR8 I;  1OPH A;  3CVM A;  2WXY C;  1OC0 A;  2XN6 A;  3EVJ I;  2PEE A;  4R9I A;  4DY7 C;  2B5T I;  3LW2 A;  1BY7 A;  3KCG I;  4ROB A;  3NDA A;  4Y3K A;  2RIV A;  2VH4 A;  1M93 B;  2ZV6 A;  5IO1 A;  1ANT I;  1UHG A;  1XQJ A;  2ACH A;  3Q03 A;  2B4X I;  2HIJ L;  4RSQ A;  9API A;  4EB1 I;  2H4R A;  2H4Q A;  2OAY A;  1JTI A;  2ANT I;  4AU2 A;  4G8R A;  2WY1 A;  1JMJ A;  2HIJ I;  1OVA B;  4DTE A;  1WZ9 A;  4KDS A;  3EOX A;  1JMO A;  4AFX A;  1F0C A;  3R4L A;  2VDY A;  3UT3 A;  1K9O I;  2XN5 A;  2RIW A;  3LE2 A;  3F5N A;  3DY0 A;  1JRR A;  1XU8 A;  1EZX A;  3Q02 A;  5HGC A;  1JJO C;  3F02 A;  5BRR I;  2B4X L;  1LQ8 A;  5EI0 A;  1R1L I;  4X30 A;  4EB1 L;  5CDX A;  4C49 A;  1OO8 A;  1OYH L;  1KCT A;  7API A;  3PZF A;  2WY0 C;  1DZG L;  2HI9 A;  3VVJ A;  1AZX I;  9PAI A;  5C98 A;  1MTP A;  4PYW A;  1OYH I;  2R9Y A;  3STO A;  1XQG A;  3T1P A;  3F1S A;  1SR5 A;  3PB1 I;  1DZG I;  1D5S A; 
#chains in the Genus database with same CATH topology
 2DUT A;  1ATH A;  4CAA A;  4BB2 A;  1SEK A;  3CWL A;  1LJ5 A;  1QLP A;  1C5G A;  1DZH L;  4AJT A;  3DLW A;  1HP7 A;  3DRM A;  2WXW A;  3NE4 A;  2WXZ A;  1LK6 I;  1DZH I;  4G8O A;  1E05 I;  4C41 A;  2GD4 C;  3CWM A;  4AU3 B;  5CDZ A;  8API A;  1TB6 I;  3FGQ A;  4ZK0 A;  1JVQ I;  1PSI A;  2D26 A;  4RO9 A;  4AQH A;  1ATT A;  4IC0 A;  3NDD A;  1T1F A;  2QUG A;  4DY0 A;  5INW A;  2ZNH A;  2BEH L;  1A7C A;  1DVN A;  1QMN A;  2VDX A;  2ARR A;  1OVA C;  4GA7 A;  5CE0 A;  1DB2 A;  2H4P A;  1AS4 A;  4Y40 A;  4ZK3 A;  2WXX A;  2BEH I;  1SNG A;  1HLE A;  1OVA A;  2WXZ C;  1E04 I;  1B3K A;  2XN3 A;  4YIA A;  1DVM A;  1NQ9 I;  4P0F A;  4AU4 A;  1C8O A;  3H5C A;  1ATU A;  2CEO A;  1IMV A;  3CAA A;  4AJU A;  2V95 A;  1E03 I;  1IZ2 A;  4ROA A;  4AU3 A;  3DRU A;  3B9F I;  3NDF A;  4P0O A;  3ZHA A;  2ARQ A;  2XN7 A;  4IF8 A;  2PEF A;  1YXA A;  1QMB A;  2OL2 A;  3OZQ A;  1BR8 I;  1OPH A;  3CVM A;  2WXY C;  1OC0 A;  2XN6 A;  3EVJ I;  2PEE A;  4R9I A;  4DY7 C;  2B5T I;  3LW2 A;  1BY7 A;  3KCG I;  4ROB A;  3NDA A;  4Y3K A;  2RIV A;  2VH4 A;  1M93 B;  2ZV6 A;  5IO1 A;  1ANT I;  1UHG A;  1XQJ A;  2ACH A;  3Q03 A;  2B4X I;  2HIJ L;  4RSQ A;  9API A;  4EB1 I;  2H4R A;  2H4Q A;  2OAY A;  1JTI A;  2ANT I;  4AU2 A;  4G8R A;  2WY1 A;  1JMJ A;  2HIJ I;  1OVA B;  4DTE A;  1WZ9 A;  4KDS A;  3EOX A;  1JMO A;  4AFX A;  1F0C A;  3R4L A;  2VDY A;  3UT3 A;  1K9O I;  2XN5 A;  2RIW A;  3LE2 A;  3F5N A;  3DY0 A;  1JRR A;  1XU8 A;  1EZX A;  3Q02 A;  5HGC A;  1JJO C;  3F02 A;  5BRR I;  2B4X L;  1LQ8 A;  5EI0 A;  1R1L I;  4X30 A;  4EB1 L;  5CDX A;  4C49 A;  1OO8 A;  1OYH L;  1KCT A;  7API A;  3PZF A;  2WY0 C;  1DZG L;  2HI9 A;  3VVJ A;  1AZX I;  9PAI A;  5C98 A;  1MTP A;  4PYW A;  1OYH I;  2R9Y A;  3STO A;  1XQG A;  3T1P A;  3F1S A;  1SR5 A;  3PB1 I;  1DZG I;  1D5S A; 
#chains in the Genus database with same CATH homology
 2DUT A;  1ATH A;  4CAA A;  4BB2 A;  1SEK A;  3CWL A;  1LJ5 A;  1QLP A;  1C5G A;  1DZH L;  4AJT A;  3DLW A;  1HP7 A;  3DRM A;  2WXW A;  3NE4 A;  2WXZ A;  1LK6 I;  1DZH I;  4G8O A;  1E05 I;  4C41 A;  2GD4 C;  3CWM A;  4AU3 B;  5CDZ A;  8API A;  1TB6 I;  3FGQ A;  4ZK0 A;  1JVQ I;  1PSI A;  2D26 A;  4RO9 A;  4AQH A;  1ATT A;  4IC0 A;  3NDD A;  1T1F A;  2QUG A;  4DY0 A;  5INW A;  2ZNH A;  2BEH L;  1A7C A;  1DVN A;  1QMN A;  2VDX A;  2ARR A;  1OVA C;  4GA7 A;  5CE0 A;  1DB2 A;  2H4P A;  1AS4 A;  4Y40 A;  4ZK3 A;  2WXX A;  2BEH I;  1SNG A;  1HLE A;  1OVA A;  2WXZ C;  1E04 I;  1B3K A;  2XN3 A;  4YIA A;  1DVM A;  1NQ9 I;  4P0F A;  4AU4 A;  1C8O A;  3H5C A;  1ATU A;  2CEO A;  1IMV A;  3CAA A;  4AJU A;  2V95 A;  1E03 I;  1IZ2 A;  4ROA A;  4AU3 A;  3DRU A;  3B9F I;  3NDF A;  4P0O A;  3ZHA A;  2ARQ A;  2XN7 A;  4IF8 A;  2PEF A;  1YXA A;  1QMB A;  2OL2 A;  3OZQ A;  1BR8 I;  1OPH A;  3CVM A;  2WXY C;  1OC0 A;  2XN6 A;  3EVJ I;  2PEE A;  4R9I A;  4DY7 C;  2B5T I;  3LW2 A;  1BY7 A;  3KCG I;  4ROB A;  3NDA A;  4Y3K A;  2RIV A;  2VH4 A;  1M93 B;  2ZV6 A;  5IO1 A;  1ANT I;  1UHG A;  1XQJ A;  2ACH A;  3Q03 A;  2B4X I;  2HIJ L;  4RSQ A;  9API A;  4EB1 I;  2H4R A;  2H4Q A;  2OAY A;  1JTI A;  2ANT I;  4AU2 A;  4G8R A;  2WY1 A;  1JMJ A;  2HIJ I;  1OVA B;  4DTE A;  1WZ9 A;  4KDS A;  3EOX A;  1JMO A;  4AFX A;  1F0C A;  3R4L A;  2VDY A;  3UT3 A;  1K9O I;  2XN5 A;  2RIW A;  3LE2 A;  3F5N A;  3DY0 A;  1JRR A;  1XU8 A;  1EZX A;  3Q02 A;  5HGC A;  1JJO C;  3F02 A;  5BRR I;  2B4X L;  1LQ8 A;  5EI0 A;  1R1L I;  4X30 A;  4EB1 L;  5CDX A;  4C49 A;  1OO8 A;  1OYH L;  1KCT A;  7API A;  3PZF A;  2WY0 C;  1DZG L;  2HI9 A;  3VVJ A;  1AZX I;  9PAI A;  5C98 A;  1MTP A;  4PYW A;  1OYH I;  2R9Y A;  3STO A;  1XQG A;  3T1P A;  3F1S A;  1SR5 A;  3PB1 I;  1DZG I;  1D5S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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