2YSFA

Solution structure of the fourth ww domain from the human e3 ubiquitin-protein ligase itchy homolog, itch
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
40
structure length
40
Chain Sequence
GSSGSSGLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of the fourth WW domain from the human E3 ubiquitin-protein ligase Itchy homolog, ITCH
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
total genus 1
structure length 40
sequence length 40
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2007-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2ysfA01
2XPBA 2RE3A 2L4JA 3L4HA 2XP3A 2YSFA 2ZAJA 2MDIA 2ITKA 2JMFA 3ODKA 5AHTA 2ZQVA 2M3OW 3KABA 3TC5A 2LAJA 2DK1A 4U84A 3M85A 3KADA 2ZQTA 2ZR5A 2DJYA 2E45A 2BA1A 2XP8A 4E5RA 2ZR6A 1K9QA 1PINA 2ZQSA 4QIBA 2JV4A 2ZQUA 4U85A 1I5HW 2JX8A 2YSGA 1EG3A 3KCEA 2Q5AA 3NTPA 2EZ5W 2M8JA 2YSBA 2XP4A 4U86A 2XP5A 2XP7A 5CQ2A 2XP6A 3M7NA 2XP9A 3CNGA 1NMVA 2DK7A 1YW5A 3KAGA 2YSHA 3KAHA 4REXA 2M8IA 2F21A 3KAIA 3KAFA 1O6WA 3WH0A 3LE4A 2XPAA 2DMVA 2KXQA 1K9RA 2DWVA 1EG4A 1WR7A 2JXWA 3OOBA 1JMQA 2YSIA 2ZR4A 1ZCNA 1F8AB 3TDBA 1TK7A 1WMVA 3TCZA
chains in the Genus database with same CATH superfamily
2XPBA 2Y8NB 2QRVA 2RE3A 2L4JA 3L4HA 2XP3A 2YSFA 2ZAJA 2MDIA 3FS8A 2ITKA 2JMFA 3ODKA 5AHTA 2ZQVA 2M3OW 3KABA 3TC5A 2LAJA 5E5WA 2DK1A 4U84A 3M85A 3KADA 4A0UA 3MCBB 2ZQTA 2ZR5A 2DJYA 2E45A 5E66A 2YAJB 2BA1A 2XP8A 4E5RA 2ZR6A 1K9QA 5E65A 1PINA 2ZQSA 4QIBA 2JV4A 1TR8A 2ZQUA 4U85A 1I5HW 5U47A 2OWOA 2JX8A 2YSGA 1EG3A 2WAEA 3KCEA 2Q5AA 3NTPA 2EZ5W 2M8JA 2YSBA 2XP4A 2WADA 4U86A 2XP5A 2XP7A 5CQ2A 2XP6A 3MQGA 4A0TA 1FLCA 5E64A 3M7NA 2XP9A 3CNGA 1NMVA 2DK7A 1YW5A 3KAGA 2YSHA 3KAHA 4REXA 3LKXB 2M8IA 2F21A 3KAIA 3KAFA 3PQHA 3FSBA 1O6WA 3WH0A 3LE4A 3MCBA 2XPAA 5E62A 2DMVA 1RP5A 3FSCA 2KXQA 1K9RA 2DWVA 1EG4A 1WR7A 2JXWA 3OOBA 4GLXA 1JMQA 2YSIA 3LKXA 2ZR4A 3MQHA 1ZCNA 1F8AB 3TDBA 1TK7A 1WMVA 3TCZA
chains in the Genus database with same CATH topology
2XPBA 2Y8NB 2QRVA 2RE3A 2L4JA 3L4HA 2XP3A 2YSFA 2ZAJA 2MDIA 3FS8A 2ITKA 2JMFA 3ODKA 5AHTA 2ZQVA 2M3OW 3KABA 3TC5A 2LAJA 5E5WA 2DK1A 4U84A 3M85A 3KADA 4A0UA 3MCBB 2ZQTA 2ZR5A 2DJYA 2E45A 5E66A 2YAJB 2BA1A 2XP8A 4E5RA 2ZR6A 1K9QA 5E65A 1PINA 2ZQSA 4QIBA 2JV4A 1TR8A 2ZQUA 4U85A 1I5HW 5U47A 2OWOA 2JX8A 2YSGA 1EG3A 2WAEA 3KCEA 2Q5AA 3NTPA 2EZ5W 2M8JA 2YSBA 2XP4A 2WADA 4U86A 2XP5A 2XP7A 5CQ2A 2XP6A 3MQGA 4A0TA 1FLCA 5E64A 3M7NA 2XP9A 3CNGA 1NMVA 2DK7A 1YW5A 3KAGA 2YSHA 3KAHA 4REXA 3LKXB 2M8IA 2F21A 3KAIA 3KAFA 3PQHA 3FSBA 1O6WA 3WH0A 3LE4A 3MCBA 2XPAA 5E62A 2DMVA 1RP5A 3FSCA 2KXQA 1K9RA 2DWVA 1EG4A 1WR7A 2JXWA 3OOBA 4GLXA 1JMQA 2YSIA 3LKXA 2ZR4A 3MQHA 1ZCNA 1F8AB 3TDBA 1TK7A 1WMVA 3TCZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XPB A;  2RE3 A;  2L4J A;  3L4H A;  2XP3 A;  2YSF A;  2ZAJ A;  2MDI A;  2ITK A;  2JMF A;  3ODK A;  5AHT A;  2ZQV A;  2M3O W;  3KAB A;  3TC5 A;  2LAJ A;  2DK1 A;  4U84 A;  3M85 A;  3KAD A;  2ZQT A;  2ZR5 A;  2DJY A;  2E45 A;  2BA1 A;  2XP8 A;  4E5R A;  2ZR6 A;  1K9Q A;  1PIN A;  2ZQS A;  4QIB A;  2JV4 A;  2ZQU A;  4U85 A;  1I5H W;  2JX8 A;  2YSG A;  1EG3 A;  3KCE A;  2Q5A A;  3NTP A;  2EZ5 W;  2M8J A;  2YSB A;  2XP4 A;  4U86 A;  2XP5 A;  2XP7 A;  5CQ2 A;  2XP6 A;  3M7N A;  2XP9 A;  3CNG A;  1NMV A;  2DK7 A;  1YW5 A;  3KAG A;  2YSH A;  3KAH A;  4REX A;  2M8I A;  2F21 A;  3KAI A;  3KAF A;  1O6W A;  3WH0 A;  3LE4 A;  2XPA A;  2DMV A;  2KXQ A;  1K9R A;  2DWV A;  1EG4 A;  1WR7 A;  2JXW A;  3OOB A;  1JMQ A;  2YSI A;  2ZR4 A;  1ZCN A;  1F8A B;  3TDB A;  1TK7 A;  1WMV A;  3TCZ A; 
#chains in the Genus database with same CATH topology
 2XPB A;  2Y8N B;  2QRV A;  2RE3 A;  2L4J A;  3L4H A;  2XP3 A;  2YSF A;  2ZAJ A;  2MDI A;  3FS8 A;  2ITK A;  2JMF A;  3ODK A;  5AHT A;  2ZQV A;  2M3O W;  3KAB A;  3TC5 A;  2LAJ A;  5E5W A;  2DK1 A;  4U84 A;  3M85 A;  3KAD A;  4A0U A;  3MCB B;  2ZQT A;  2ZR5 A;  2DJY A;  2E45 A;  5E66 A;  2YAJ B;  2BA1 A;  2XP8 A;  4E5R A;  2ZR6 A;  1K9Q A;  5E65 A;  1PIN A;  2ZQS A;  4QIB A;  2JV4 A;  1TR8 A;  2ZQU A;  4U85 A;  1I5H W;  5U47 A;  2OWO A;  2JX8 A;  2YSG A;  1EG3 A;  2WAE A;  3KCE A;  2Q5A A;  3NTP A;  2EZ5 W;  2M8J A;  2YSB A;  2XP4 A;  2WAD A;  4U86 A;  2XP5 A;  2XP7 A;  5CQ2 A;  2XP6 A;  3MQG A;  4A0T A;  1FLC A;  5E64 A;  3M7N A;  2XP9 A;  3CNG A;  1NMV A;  2DK7 A;  1YW5 A;  3KAG A;  2YSH A;  3KAH A;  4REX A;  3LKX B;  2M8I A;  2F21 A;  3KAI A;  3KAF A;  3PQH A;  3FSB A;  1O6W A;  3WH0 A;  3LE4 A;  3MCB A;  2XPA A;  5E62 A;  2DMV A;  1RP5 A;  3FSC A;  2KXQ A;  1K9R A;  2DWV A;  1EG4 A;  1WR7 A;  2JXW A;  3OOB A;  4GLX A;  1JMQ A;  2YSI A;  3LKX A;  2ZR4 A;  3MQH A;  1ZCN A;  1F8A B;  3TDB A;  1TK7 A;  1WMV A;  3TCZ A; 
#chains in the Genus database with same CATH homology
 2XPB A;  2Y8N B;  2QRV A;  2RE3 A;  2L4J A;  3L4H A;  2XP3 A;  2YSF A;  2ZAJ A;  2MDI A;  3FS8 A;  2ITK A;  2JMF A;  3ODK A;  5AHT A;  2ZQV A;  2M3O W;  3KAB A;  3TC5 A;  2LAJ A;  5E5W A;  2DK1 A;  4U84 A;  3M85 A;  3KAD A;  4A0U A;  3MCB B;  2ZQT A;  2ZR5 A;  2DJY A;  2E45 A;  5E66 A;  2YAJ B;  2BA1 A;  2XP8 A;  4E5R A;  2ZR6 A;  1K9Q A;  5E65 A;  1PIN A;  2ZQS A;  4QIB A;  2JV4 A;  1TR8 A;  2ZQU A;  4U85 A;  1I5H W;  5U47 A;  2OWO A;  2JX8 A;  2YSG A;  1EG3 A;  2WAE A;  3KCE A;  2Q5A A;  3NTP A;  2EZ5 W;  2M8J A;  2YSB A;  2XP4 A;  2WAD A;  4U86 A;  2XP5 A;  2XP7 A;  5CQ2 A;  2XP6 A;  3MQG A;  4A0T A;  1FLC A;  5E64 A;  3M7N A;  2XP9 A;  3CNG A;  1NMV A;  2DK7 A;  1YW5 A;  3KAG A;  2YSH A;  3KAH A;  4REX A;  3LKX B;  2M8I A;  2F21 A;  3KAI A;  3KAF A;  3PQH A;  3FSB A;  1O6W A;  3WH0 A;  3LE4 A;  3MCB A;  2XPA A;  5E62 A;  2DMV A;  1RP5 A;  3FSC A;  2KXQ A;  1K9R A;  2DWV A;  1EG4 A;  1WR7 A;  2JXW A;  3OOB A;  4GLX A;  1JMQ A;  2YSI A;  3LKX A;  2ZR4 A;  3MQH A;  1ZCN A;  1F8A B;  3TDB A;  1TK7 A;  1WMV A;  3TCZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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