3B92A

Novel thio-based tace inhibitors part 2: rational design, synthesis and sar of thiol-contaning aryl sufones
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
259
structure length
259
Chain Sequence
b'ADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADAM 17
publication title Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 83
structure length 259
sequence length 259
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2007-11-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3b92A00
4DD8A 1JAQA 1JK3A 3LEAA 2RJPA 3HDAP 3KHIA 4H1QA 1Q3AA 3USNA 1UTZA 1BKCI 1MMQA 3HY7A 2DW0A 3LUNA 1BQOA 3TT4A 1BM6A 4L63A 4JIJA 1GE5A 3LKAA 5D1TA 1KUGA 3LJZA 4H49A 3KWVC 1JKYA 2OXZA 2CLTA 1I76A 3EHYA 3N2VA 4XBHA 1BUVM 3NX7A 1SLNA 1IABA 2JSDA 1OM8A 1MMRA 2OY2A 4GUYA 5D3CA 4XCTA 4A3WA 1BQQM 1IACA 2SRTA 2MLRA 1XFWA 1GKCA 2JIHA 1EAKA 2JNPA 1ASTA 1H71P 4WKEA 1ROSA 1KBCA 4CTHA 1OM6A 2QPJA 3F18A 4JA1A 1HFCA 2X3BA 2OW0A 5I12A 2X7MA 1GE7A 1CIZA 4FVLA 3KEJA 2XS3A 2Z2DA 4WKIA 1G49A 1OS9A 4IUWA 1SLMA 1KUFA 4PKRA 1HV5A 4DF9A 3TVCA 2POJA 1JJ9A 4H82A 1FLSA 4G0DA 1KAPP 3KMCA 3KECA 1CXVA 1S4BP 2WO8A 4PKSA 3RTSA 4EFSA 5LABA 1AKLA 1ATLA 1RMZA 2AYKA 1QJIA 2W15A 2ERQA 3RTTA 1I1IP 1JAOA 2MZEA 3LILA 4IN9A 4JP4A 1HFSA 4GR8A 4G9LA 4IJOA 4PKQA 3DNGA 1OO9A 1HY7A 1A85A 4GWMA 1MMPA 3CKIA 1SU3A 3HYGA 2XS4A 1YP1A 1MNCA 2X3CA 2L0RA 1BIWA 2WOAA 2Y6CA 1XUDA 4GWNA 4JQGA 1OM7A 1ZXCA 1R55A 1G12A 1R1IA 3O64A 1KUHA 1JIWP 2EROA 1I73A 3OHOA 1G05A 3LK8A 3EDZA 3KMEA 5I0LA 1SATA 1Y0VA 1JANA 1OMJA 5I3MA 3EWJA 2RJQA 2O36A 1K7IA 1ZTQA 1YQYA 2OXUA 3DSLA 2D1NA 4AXQA 4WZVA 3SHIA 4DV8A 2E2DA 3LUMA 5L7FA 2OY4A 2OW1A 4H2EA 1ND1A 3N2UA 1HTDA 4L19A 3VTGA 5BPAA 1IAAA 1JH1A 1IAEA 2FV9A 3LIRA 4XM6A 1G9KA 1EUBA 1R1JA 2K9CA 5CXAA 1QIAA 2DDYA 1WNIA 1GXDA 1C7KA 2FV5A 3LGPA 1XFUA 5I43A 5CUHA 3G5CA 3LQ0A 1XURA 3HBVP 4I35A 1C3IA 1SRPA 2YIGA 1Y8JA 1IADA 4FU4A 1GO8P 1K7QA 2DW2A 4GQLA 3AIGA 1ZS0A 2W14A 1MMBA 3BA0A 2OI0A 1K7GA 3B8ZA 3EDHA 1R1HA 2YB9A 3LMCA 1YOUA 4HMAA 3HDBA 4PKTA 3WV1A 2OW9A 2W0DA 4XM8A 4ILWD 3EDIA 3HY9A 2CKIA 2ERPA 4PKUA 4GR3A 3U1RA 3ZUKA 4HX3A 4H76A 456CA 2JT6A 1GE6A 5D2BA 3I7GA 5I4OA 3LJGA 2OVZA 4A7BA 1IAGA 2MLSA 3Q2HA 3EHXA 3UVCA 5JMYA 2X3AA 3DPFA 1D7XA 4FXQA 3EDGA 3GBOA 3F1AA 4GR0A 4AYKA 1DMTA 3G42A 1O0QA 4GF1A 5D1UA 4AUOA 2Y6DA 3I7IA 3MA2A 2TCLA 3LE9A 5I2ZA 3AYUA 2JT5A 3ELMA 1CGLA 1PWQA 3LJTA 3WV2A 2J0TA 1GKDA 3F19A 1AF0A 1PWVA 3ZVSA 1D8FA 1QIBA 4PKVA 3E8RA 1CGFA 1FBLA 1GO7P 4J4MA 2DDFA 3TSKA 5D1SA 2USNA 1PWPA 1JIZA 1XUCA 1UMSA 3ZXHA 4PKWA 4FXYP 1CGEA 1CQRA 1L6JA 5D7WA 2W13A 3V96B 3LQBA 1BUDA 1QICA 1USNA 4AIGA 2OZRA 1EB6A 830CA 1OS2A 2D1OA 1UMTA 1Z3JA 5B5OA 1AYKA 2KRJA 1KUKA 2OVXA 4JPAA 5CZMA 2HU6A 1J7NA 1FM1A 3AYKA 3B92A 4QKZA 1JAPA 4ZR5A 1A86A 1SMPA 2PJTA 2K2GA 3P1VA 3K7NA 1ZVXA 3VI1A 3F15A 1PWWA 1Y93A 3F16A 3TS4A 2I47A 1BKCE 1CK7A 3KEKA 4XM7A 1UTTA 1D8MA 1UEAA 1XFZA 2E3XA 2A8HA 3F17A 4H30A 2WO9A 1PWUA 1O0TA 1RM8A 4WF6A 1B8YA 2V4BA 4I03A 1XFXA 3DL1A 5H8XA 4ON1A 4R3VA 3DWBA 1G4KA 5L79A 3B2ZA 2MZHA 2N8RA 2AIGP 2DW1A 3O2XA 3P24A 4H84A 1XFVA 4L6TA 3Q2GA 3L0VA 1D5JA 5BOTA 3K7LA 1ZXVA 1HOVA 4WK7A 1BZSA 3LIKA 1XFYA 1BKCA 3DPEA 1YCMA 2OXWA 3HBUP 1C8TA 5B5PA 1R54A 3OHLA 1BSWA 1CAQA 1ZP5A 2J83A 1B3DA 1DTHA 5BOYA 2W12A 3WV3A 1QJJA 2O3EA 4Q1LA 3KRYA 2MZIA 3L0TA 3HB2P 966CA 4H3XA 1QUAA 1KUIA 4DPEA 2OW2A
chains in the Genus database with same CATH superfamily
4DD8A 1JAQA 1JK3A 3LEAA 2RJPA 3HDAP 3KHIA 4H1QA 1Q3AA 3USNA 1UTZA 1BKCI 1MMQA 3HY7A 2DW0A 3LUNA 1BQOA 3TT4A 1BM6A 4L63A 4JIJA 1GE5A 3LKAA 5D1TA 1KUGA 3LJZA 4H49A 3KWVC 1JKYA 2OXZA 2CLTA 1I76A 3EHYA 3N2VA 4XBHA 1BUVM 3NX7A 1SLNA 1IABA 3DTEA 2JSDA 1OM8A 1MMRA 2OY2A 4GUYA 5D3CA 4XCTA 4A3WA 1BQQM 1IACA 2SRTA 2MLRA 1XFWA 1GKCA 2JIHA 1EAKA 2JNPA 1ASTA 1H71P 4WKEA 1ROSA 1KBCA 4CTHA 1OM6A 2QPJA 3F18A 4L7AA 4JA1A 1HFCA 2X3BA 2OW0A 5I12A 2X7MA 1XAXA 1GE7A 1CIZA 4FVLA 3KEJA 2XS3A 2Z2DA 4WKIA 1G49A 1OS9A 4IUWA 1SLMA 1KUFA 4PKRA 1HV5A 4DF9A 3TVCA 2POJA 1JJ9A 4H82A 1FLSA 4G0DA 1KAPP 3KMCA 3KECA 1CXVA 1S4BP 2WO8A 4PKSA 3RTSA 4EFSA 5LABA 1AKLA 1ATLA 1RMZA 2AYKA 1QJIA 2W15A 2ERQA 3RTTA 1I1IP 1JAOA 2MZEA 3LILA 4IN9A 4JP4A 1HFSA 1TVIA 4GR8A 4G9LA 4IJOA 4PKQA 3DNGA 1OO9A 1HY7A 1A85A 4GWMA 1MMPA 3CKIA 1SU3A 3HYGA 2XS4A 1YP1A 1MNCA 2X3CA 2L0RA 1BIWA 2WOAA 2Y6CA 1XUDA 4GWNA 4JQGA 1OM7A 1ZXCA 1R55A 1G12A 1R1IA 3O64A 1KUHA 1JIWP 2EROA 1I73A 3OHOA 1G05A 3LK8A 3EDZA 3KMEA 5I0LA 1SATA 1Y0VA 1JANA 1OMJA 5I3MA 3EWJA 2RJQA 2O36A 1K7IA 1ZTQA 1YQYA 2OXUA 3DSLA 2D1NA 3DTKA 4AXQA 4WZVA 3SHIA 4DV8A 2E2DA 3LUMA 5L7FA 2OY4A 2OW1A 4H2EA 1ND1A 3N2UA 1HTDA 4L19A 3VTGA 5BPAA 1IAAA 1JH1A 1IAEA 3DTIA 2FV9A 3LIRA 4XM6A 1G9KA 1EUBA 1R1JA 2K9CA 5CXAA 1QIAA 2DDYA 1WNIA 1GXDA 1C7KA 2FV5A 3LGPA 1XFUA 5I43A 5CUHA 3G5CA 3LQ0A 1XURA 3HBVP 4I35A 1C3IA 1SRPA 2YIGA 1Y8JA 1IADA 4FU4A 1GO8P 1K7QA 2DW2A 4GQLA 3AIGA 1ZS0A 2W14A 1XM5A 1MMBA 3BA0A 2OI0A 1K7GA 3B8ZA 3EDHA 1R1HA 2YB9A 3LMCA 1YOUA 4HMAA 3HDBA 4PKTA 3WV1A 2OW9A 2W0DA 4XM8A 4ILWD 3EDIA 3HY9A 2CKIA 2ERPA 4PKUA 4GR3A 3U1RA 3ZUKA 4HX3A 4H76A 456CA 2JT6A 1GE6A 5D2BA 3I7GA 5I4OA 3LJGA 2OVZA 4A7BA 1IAGA 2MLSA 3Q2HA 3EHXA 3UVCA 5JMYA 2X3AA 3DPFA 1D7XA 4FXQA 3EDGA 3GBOA 3F1AA 4GR0A 4AYKA 1DMTA 3G42A 1O0QA 4GF1A 5D1UA 4AUOA 2Y6DA 3I7IA 3MA2A 2TCLA 3LE9A 5I2ZA 3AYUA 2JT5A 3ELMA 1CGLA 1PWQA 3LJTA 3WV2A 2J0TA 1GKDA 3F19A 1AF0A 1PWVA 3ZVSA 1D8FA 1QIBA 4PKVA 3E8RA 1CGFA 1FBLA 1GO7P 4J4MA 2DDFA 3TSKA 5D1SA 2USNA 1PWPA 1JIZA 1XUCA 1UMSA 3ZXHA 4PKWA 4FXYP 1CGEA 1CQRA 1L6JA 5D7WA 2W13A 3V96B 3LQBA 1BUDA 1QICA 1USNA 4AIGA 2OZRA 1EB6A 830CA 1OS2A 2D1OA 1UMTA 1Z3JA 5B5OA 1AYKA 2KRJA 1KUKA 2OVXA 4JPAA 5CZMA 2HU6A 1J7NA 1FM1A 3AYKA 3B92A 4QKZA 1JAPA 4ZR5A 1A86A 1SMPA 2PJTA 2K2GA 3P1VA 3K7NA 1ZVXA 3VI1A 3F15A 1PWWA 1Y93A 3F16A 3TS4A 2I47A 1BKCE 1CK7A 3KEKA 1OZ9A 4XM7A 1UTTA 1D8MA 1UEAA 1XFZA 2E3XA 2A8HA 3F17A 4H30A 2WO9A 1PWUA 1O0TA 1RM8A 4WF6A 1B8YA 2V4BA 2YUFA 4I03A 1XFXA 3DL1A 5H8XA 4ON1A 4R3VA 3DWBA 1G4KA 5L79A 3B2ZA 2MZHA 2N8RA 2AIGP 2DW1A 3O2XA 3P24A 4H84A 1XFVA 4L6TA 3Q2GA 3L0VA 1D5JA 5BOTA 3K7LA 1ZXVA 1HOVA 4WK7A 1BZSA 3LIKA 1XFYA 1BKCA 3DPEA 1YCMA 2OXWA 3HBUP 1C8TA 5B5PA 1R54A 3OHLA 1BSWA 1CAQA 1ZP5A 2J83A 1B3DA 1DTHA 5BOYA 2W12A 3WV3A 1QJJA 2O3EA 4Q1LA 3KRYA 2MZIA 3L0TA 3HB2P 966CA 4H3XA 1QUAA 1KUIA 4DPEA 2OW2A
chains in the Genus database with same CATH topology
4DD8A 1JAQA 1JK3A 3LEAA 2RJPA 3HDAP 3KHIA 4H1QA 1Q3AA 3USNA 1UTZA 1BKCI 1MMQA 3HY7A 2DW0A 3LUNA 1BQOA 3TT4A 1BM6A 4L63A 4JIJA 1GE5A 3LKAA 5D1TA 1KUGA 3LJZA 4H49A 3KWVC 1JKYA 2OXZA 2CLTA 1I76A 3EHYA 3N2VA 4XBHA 1BUVM 3NX7A 1SLNA 1IABA 3DTEA 2JSDA 1OM8A 1MMRA 2OY2A 4GUYA 5D3CA 4XCTA 4A3WA 1BQQM 1IACA 2SRTA 2MLRA 1XFWA 1GKCA 2JIHA 1EAKA 2JNPA 1ASTA 1H71P 4WKEA 1ROSA 1KBCA 4CTHA 1OM6A 2QPJA 3F18A 4L7AA 4JA1A 1HFCA 2X3BA 2OW0A 5I12A 2X7MA 1GE7A 1CIZA 4FVLA 3KEJA 2XS3A 2Z2DA 4WKIA 1G49A 1OS9A 4IUWA 1SLMA 1KUFA 4PKRA 1HV5A 4DF9A 3TVCA 2POJA 1JJ9A 4H82A 1FLSA 4G0DA 1KAPP 3KMCA 3KECA 1CXVA 1S4BP 2WO8A 4PKSA 3RTSA 4EFSA 5LABA 1AKLA 1ATLA 1RMZA 2AYKA 1QJIA 2W15A 2ERQA 3RTTA 1I1IP 1JAOA 2MZEA 3LILA 4IN9A 4JP4A 1HFSA 4GR8A 4G9LA 4IJOA 4PKQA 3DNGA 1OO9A 1HY7A 1A85A 4GWMA 1MMPA 3CKIA 1SU3A 3HYGA 2XS4A 1YP1A 1MNCA 2X3CA 2L0RA 1BIWA 2WOAA 2Y6CA 1XUDA 4GWNA 4JQGA 1OM7A 1ZXCA 1R55A 1G12A 1R1IA 3O64A 1KUHA 1JIWP 2EROA 1I73A 3OHOA 1G05A 3LK8A 3EDZA 3KMEA 5I0LA 1SATA 1Y0VA 1JANA 1OMJA 5I3MA 3EWJA 2RJQA 2O36A 1K7IA 1ZTQA 1YQYA 2OXUA 3DSLA 2D1NA 3DTKA 4AXQA 4WZVA 3SHIA 4DV8A 2E2DA 3LUMA 5L7FA 2OY4A 2OW1A 4H2EA 1ND1A 3N2UA 1HTDA 4L19A 3VTGA 5BPAA 1IAAA 1JH1A 1IAEA 3DTIA 2FV9A 3LIRA 4XM6A 1G9KA 1EUBA 1R1JA 2K9CA 5CXAA 1QIAA 2DDYA 1WNIA 1GXDA 1C7KA 2FV5A 3LGPA 1XFUA 5I43A 5CUHA 3G5CA 3LQ0A 1XURA 3HBVP 4I35A 1C3IA 1SRPA 2YIGA 1Y8JA 1IADA 4FU4A 1GO8P 1K7QA 2DW2A 4GQLA 3AIGA 1ZS0A 2W14A 1MMBA 3BA0A 2OI0A 1K7GA 3B8ZA 3EDHA 1R1HA 2YB9A 3LMCA 1YOUA 4HMAA 3HDBA 4PKTA 3WV1A 2OW9A 2W0DA 4XM8A 4ILWD 3EDIA 3HY9A 2CKIA 2ERPA 4PKUA 4GR3A 3U1RA 3ZUKA 4HX3A 4H76A 456CA 2JT6A 1GE6A 5D2BA 3I7GA 5I4OA 3LJGA 2OVZA 4A7BA 1IAGA 2MLSA 3Q2HA 3EHXA 3UVCA 5JMYA 2X3AA 3DPFA 1D7XA 4FXQA 3EDGA 3GBOA 3F1AA 4GR0A 4AYKA 1DMTA 3G42A 1O0QA 4GF1A 5D1UA 4AUOA 2Y6DA 3I7IA 3MA2A 2TCLA 3LE9A 5I2ZA 3AYUA 2JT5A 3ELMA 1CGLA 1PWQA 3LJTA 3WV2A 2J0TA 1GKDA 3F19A 1AF0A 1PWVA 3ZVSA 1D8FA 1QIBA 4PKVA 3E8RA 1CGFA 1FBLA 1GO7P 4J4MA 2DDFA 3TSKA 5D1SA 2USNA 1PWPA 1JIZA 1XUCA 1UMSA 3ZXHA 4PKWA 4FXYP 1CGEA 1CQRA 1L6JA 5D7WA 2W13A 3V96B 3LQBA 1BUDA 1QICA 1USNA 4AIGA 2OZRA 1EB6A 830CA 1OS2A 2D1OA 1UMTA 1Z3JA 5B5OA 1AYKA 2KRJA 1KUKA 2OVXA 4JPAA 5CZMA 2HU6A 1J7NA 1FM1A 3AYKA 3B92A 4QKZA 1JAPA 4ZR5A 1A86A 1SMPA 2PJTA 2K2GA 3P1VA 3K7NA 1ZVXA 3VI1A 3F15A 1PWWA 1Y93A 3F16A 3TS4A 2I47A 1BKCE 1CK7A 3KEKA 4XM7A 1UTTA 1D8MA 1UEAA 1XFZA 2E3XA 2A8HA 3F17A 4H30A 2WO9A 1PWUA 1O0TA 1RM8A 4WF6A 1B8YA 2V4BA 2YUFA 4I03A 1XFXA 3DL1A 5H8XA 4ON1A 4R3VA 3DWBA 1G4KA 5L79A 3B2ZA 2MZHA 2N8RA 2AIGP 2DW1A 3O2XA 3P24A 4H84A 1XFVA 4L6TA 3Q2GA 3L0VA 1D5JA 5BOTA 3K7LA 1ZXVA 1HOVA 4WK7A 1BZSA 3LIKA 1XFYA 1BKCA 3DPEA 1YCMA 2OXWA 3HBUP 1C8TA 5B5PA 1R54A 3OHLA 1BSWA 1CAQA 1ZP5A 2J83A 1B3DA 1DTHA 5BOYA 2W12A 3WV3A 1QJJA 2O3EA 4Q1LA 3KRYA 2MZIA 3L0TA 3HB2P 966CA 4H3XA 1QUAA 1KUIA 4DPEA 2OW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DD8 A;  1JAQ A;  1JK3 A;  3LEA A;  2RJP A;  3HDA P;  3KHI A;  4H1Q A;  1Q3A A;  3USN A;  1UTZ A;  1BKC I;  1MMQ A;  3HY7 A;  2DW0 A;  3LUN A;  1BQO A;  3TT4 A;  1BM6 A;  4L63 A;  4JIJ A;  1GE5 A;  3LKA A;  5D1T A;  1KUG A;  3LJZ A;  4H49 A;  3KWV C;  1JKY A;  2OXZ A;  2CLT A;  1I76 A;  3EHY A;  3N2V A;  4XBH A;  1BUV M;  3NX7 A;  1SLN A;  1IAB A;  2JSD A;  1OM8 A;  1MMR A;  2OY2 A;  4GUY A;  5D3C A;  4XCT A;  4A3W A;  1BQQ M;  1IAC A;  2SRT A;  2MLR A;  1XFW A;  1GKC A;  2JIH A;  1EAK A;  2JNP A;  1AST A;  1H71 P;  4WKE A;  1ROS A;  1KBC A;  4CTH A;  1OM6 A;  2QPJ A;  3F18 A;  4JA1 A;  1HFC A;  2X3B A;  2OW0 A;  5I12 A;  2X7M A;  1GE7 A;  1CIZ A;  4FVL A;  3KEJ A;  2XS3 A;  2Z2D A;  4WKI A;  1G49 A;  1OS9 A;  4IUW A;  1SLM A;  1KUF A;  4PKR A;  1HV5 A;  4DF9 A;  3TVC A;  2POJ A;  1JJ9 A;  4H82 A;  1FLS A;  4G0D A;  1KAP P;  3KMC A;  3KEC A;  1CXV A;  1S4B P;  2WO8 A;  4PKS A;  3RTS A;  4EFS A;  5LAB A;  1AKL A;  1ATL A;  1RMZ A;  2AYK A;  1QJI A;  2W15 A;  2ERQ A;  3RTT A;  1I1I P;  1JAO A;  2MZE A;  3LIL A;  4IN9 A;  4JP4 A;  1HFS A;  4GR8 A;  4G9L A;  4IJO A;  4PKQ A;  3DNG A;  1OO9 A;  1HY7 A;  1A85 A;  4GWM A;  1MMP A;  3CKI A;  1SU3 A;  3HYG A;  2XS4 A;  1YP1 A;  1MNC A;  2X3C A;  2L0R A;  1BIW A;  2WOA A;  2Y6C A;  1XUD A;  4GWN A;  4JQG A;  1OM7 A;  1ZXC A;  1R55 A;  1G12 A;  1R1I A;  3O64 A;  1KUH A;  1JIW P;  2ERO A;  1I73 A;  3OHO A;  1G05 A;  3LK8 A;  3EDZ A;  3KME A;  5I0L A;  1SAT A;  1Y0V A;  1JAN A;  1OMJ A;  5I3M A;  3EWJ A;  2RJQ A;  2O36 A;  1K7I A;  1ZTQ A;  1YQY A;  2OXU A;  3DSL A;  2D1N A;  4AXQ A;  4WZV A;  3SHI A;  4DV8 A;  2E2D A;  3LUM A;  5L7F A;  2OY4 A;  2OW1 A;  4H2E A;  1ND1 A;  3N2U A;  1HTD A;  4L19 A;  3VTG A;  5BPA A;  1IAA A;  1JH1 A;  1IAE A;  2FV9 A;  3LIR A;  4XM6 A;  1G9K A;  1EUB A;  1R1J A;  2K9C A;  5CXA A;  1QIA A;  2DDY A;  1WNI A;  1GXD A;  1C7K A;  2FV5 A;  3LGP A;  1XFU A;  5I43 A;  5CUH A;  3G5C A;  3LQ0 A;  1XUR A;  3HBV P;  4I35 A;  1C3I A;  1SRP A;  2YIG A;  1Y8J A;  1IAD A;  4FU4 A;  1GO8 P;  1K7Q A;  2DW2 A;  4GQL A;  3AIG A;  1ZS0 A;  2W14 A;  1MMB A;  3BA0 A;  2OI0 A;  1K7G A;  3B8Z A;  3EDH A;  1R1H A;  2YB9 A;  3LMC A;  1YOU A;  4HMA A;  3HDB A;  4PKT A;  3WV1 A;  2OW9 A;  2W0D A;  4XM8 A;  4ILW D;  3EDI A;  3HY9 A;  2CKI A;  2ERP A;  4PKU A;  4GR3 A;  3U1R A;  3ZUK A;  4HX3 A;  4H76 A;  456C A;  2JT6 A;  1GE6 A;  5D2B A;  3I7G A;  5I4O A;  3LJG A;  2OVZ A;  4A7B A;  1IAG A;  2MLS A;  3Q2H A;  3EHX A;  3UVC A;  5JMY A;  2X3A A;  3DPF A;  1D7X A;  4FXQ A;  3EDG A;  3GBO A;  3F1A A;  4GR0 A;  4AYK A;  1DMT A;  3G42 A;  1O0Q A;  4GF1 A;  5D1U A;  4AUO A;  2Y6D A;  3I7I A;  3MA2 A;  2TCL A;  3LE9 A;  5I2Z A;  3AYU A;  2JT5 A;  3ELM A;  1CGL A;  1PWQ A;  3LJT A;  3WV2 A;  2J0T A;  1GKD A;  3F19 A;  1AF0 A;  1PWV A;  3ZVS A;  1D8F A;  1QIB A;  4PKV A;  3E8R A;  1CGF A;  1FBL A;  1GO7 P;  4J4M A;  2DDF A;  3TSK A;  5D1S A;  2USN A;  1PWP A;  1JIZ A;  1XUC A;  1UMS A;  3ZXH A;  4PKW A;  4FXY P;  1CGE A;  1CQR A;  1L6J A;  5D7W A;  2W13 A;  3V96 B;  3LQB A;  1BUD A;  1QIC A;  1USN A;  4AIG A;  2OZR A;  1EB6 A;  830C A;  1OS2 A;  2D1O A;  1UMT A;  1Z3J A;  5B5O A;  1AYK A;  2KRJ A;  1KUK A;  2OVX A;  4JPA A;  5CZM A;  2HU6 A;  1J7N A;  1FM1 A;  3AYK A;  3B92 A;  4QKZ A;  1JAP A;  4ZR5 A;  1A86 A;  1SMP A;  2PJT A;  2K2G A;  3P1V A;  3K7N A;  1ZVX A;  3VI1 A;  3F15 A;  1PWW A;  1Y93 A;  3F16 A;  3TS4 A;  2I47 A;  1BKC E;  1CK7 A;  3KEK A;  4XM7 A;  1UTT A;  1D8M A;  1UEA A;  1XFZ A;  2E3X A;  2A8H A;  3F17 A;  4H30 A;  2WO9 A;  1PWU A;  1O0T A;  1RM8 A;  4WF6 A;  1B8Y A;  2V4B A;  4I03 A;  1XFX A;  3DL1 A;  5H8X A;  4ON1 A;  4R3V A;  3DWB A;  1G4K A;  5L79 A;  3B2Z A;  2MZH A;  2N8R A;  2AIG P;  2DW1 A;  3O2X A;  3P24 A;  4H84 A;  1XFV A;  4L6T A;  3Q2G A;  3L0V A;  1D5J A;  5BOT A;  3K7L A;  1ZXV A;  1HOV A;  4WK7 A;  1BZS A;  3LIK A;  1XFY A;  1BKC A;  3DPE A;  1YCM A;  2OXW A;  3HBU P;  1C8T A;  5B5P A;  1R54 A;  3OHL A;  1BSW A;  1CAQ A;  1ZP5 A;  2J83 A;  1B3D A;  1DTH A;  5BOY A;  2W12 A;  3WV3 A;  1QJJ A;  2O3E A;  4Q1L A;  3KRY A;  2MZI A;  3L0T A;  3HB2 P;  966C A;  4H3X A;  1QUA A;  1KUI A;  4DPE A;  2OW2 A; 
#chains in the Genus database with same CATH topology
 4DD8 A;  1JAQ A;  1JK3 A;  3LEA A;  2RJP A;  3HDA P;  3KHI A;  4H1Q A;  1Q3A A;  3USN A;  1UTZ A;  1BKC I;  1MMQ A;  3HY7 A;  2DW0 A;  3LUN A;  1BQO A;  3TT4 A;  1BM6 A;  4L63 A;  4JIJ A;  1GE5 A;  3LKA A;  5D1T A;  1KUG A;  3LJZ A;  4H49 A;  3KWV C;  1JKY A;  2OXZ A;  2CLT A;  1I76 A;  3EHY A;  3N2V A;  4XBH A;  1BUV M;  3NX7 A;  1SLN A;  1IAB A;  3DTE A;  2JSD A;  1OM8 A;  1MMR A;  2OY2 A;  4GUY A;  5D3C A;  4XCT A;  4A3W A;  1BQQ M;  1IAC A;  2SRT A;  2MLR A;  1XFW A;  1GKC A;  2JIH A;  1EAK A;  2JNP A;  1AST A;  1H71 P;  4WKE A;  1ROS A;  1KBC A;  4CTH A;  1OM6 A;  2QPJ A;  3F18 A;  4L7A A;  4JA1 A;  1HFC A;  2X3B A;  2OW0 A;  5I12 A;  2X7M A;  1XAX A;  1GE7 A;  1CIZ A;  4FVL A;  3KEJ A;  2XS3 A;  2Z2D A;  4WKI A;  1G49 A;  1OS9 A;  4IUW A;  1SLM A;  1KUF A;  4PKR A;  1HV5 A;  4DF9 A;  3TVC A;  2POJ A;  1JJ9 A;  4H82 A;  1FLS A;  4G0D A;  1KAP P;  3KMC A;  3KEC A;  1CXV A;  1S4B P;  2WO8 A;  4PKS A;  3RTS A;  4EFS A;  5LAB A;  1AKL A;  1ATL A;  1RMZ A;  2AYK A;  1QJI A;  2W15 A;  2ERQ A;  3RTT A;  1I1I P;  1JAO A;  2MZE A;  3LIL A;  4IN9 A;  4JP4 A;  1HFS A;  1TVI A;  4GR8 A;  4G9L A;  4IJO A;  4PKQ A;  3DNG A;  1OO9 A;  1HY7 A;  1A85 A;  4GWM A;  1MMP A;  3CKI A;  1SU3 A;  3HYG A;  2XS4 A;  1YP1 A;  1MNC A;  2X3C A;  2L0R A;  1BIW A;  2WOA A;  2Y6C A;  1XUD A;  4GWN A;  4JQG A;  1OM7 A;  1ZXC A;  1R55 A;  1G12 A;  1R1I A;  3O64 A;  1KUH A;  1JIW P;  2ERO A;  1I73 A;  3OHO A;  1G05 A;  3LK8 A;  3EDZ A;  3KME A;  5I0L A;  1SAT A;  1Y0V A;  1JAN A;  1OMJ A;  5I3M A;  3EWJ A;  2RJQ A;  2O36 A;  1K7I A;  1ZTQ A;  1YQY A;  2OXU A;  3DSL A;  2D1N A;  3DTK A;  4AXQ A;  4WZV A;  3SHI A;  4DV8 A;  2E2D A;  3LUM A;  5L7F A;  2OY4 A;  2OW1 A;  4H2E A;  1ND1 A;  3N2U A;  1HTD A;  4L19 A;  3VTG A;  5BPA A;  1IAA A;  1JH1 A;  1IAE A;  3DTI A;  2FV9 A;  3LIR A;  4XM6 A;  1G9K A;  1EUB A;  1R1J A;  2K9C A;  5CXA A;  1QIA A;  2DDY A;  1WNI A;  1GXD A;  1C7K A;  2FV5 A;  3LGP A;  1XFU A;  5I43 A;  5CUH A;  3G5C A;  3LQ0 A;  1XUR A;  3HBV P;  4I35 A;  1C3I A;  1SRP A;  2YIG A;  1Y8J A;  1IAD A;  4FU4 A;  1GO8 P;  1K7Q A;  2DW2 A;  4GQL A;  3AIG A;  1ZS0 A;  2W14 A;  1XM5 A;  1MMB A;  3BA0 A;  2OI0 A;  1K7G A;  3B8Z A;  3EDH A;  1R1H A;  2YB9 A;  3LMC A;  1YOU A;  4HMA A;  3HDB A;  4PKT A;  3WV1 A;  2OW9 A;  2W0D A;  4XM8 A;  4ILW D;  3EDI A;  3HY9 A;  2CKI A;  2ERP A;  4PKU A;  4GR3 A;  3U1R A;  3ZUK A;  4HX3 A;  4H76 A;  456C A;  2JT6 A;  1GE6 A;  5D2B A;  3I7G A;  5I4O A;  3LJG A;  2OVZ A;  4A7B A;  1IAG A;  2MLS A;  3Q2H A;  3EHX A;  3UVC A;  5JMY A;  2X3A A;  3DPF A;  1D7X A;  4FXQ A;  3EDG A;  3GBO A;  3F1A A;  4GR0 A;  4AYK A;  1DMT A;  3G42 A;  1O0Q A;  4GF1 A;  5D1U A;  4AUO A;  2Y6D A;  3I7I A;  3MA2 A;  2TCL A;  3LE9 A;  5I2Z A;  3AYU A;  2JT5 A;  3ELM A;  1CGL A;  1PWQ A;  3LJT A;  3WV2 A;  2J0T A;  1GKD A;  3F19 A;  1AF0 A;  1PWV A;  3ZVS A;  1D8F A;  1QIB A;  4PKV A;  3E8R A;  1CGF A;  1FBL A;  1GO7 P;  4J4M A;  2DDF A;  3TSK A;  5D1S A;  2USN A;  1PWP A;  1JIZ A;  1XUC A;  1UMS A;  3ZXH A;  4PKW A;  4FXY P;  1CGE A;  1CQR A;  1L6J A;  5D7W A;  2W13 A;  3V96 B;  3LQB A;  1BUD A;  1QIC A;  1USN A;  4AIG A;  2OZR A;  1EB6 A;  830C A;  1OS2 A;  2D1O A;  1UMT A;  1Z3J A;  5B5O A;  1AYK A;  2KRJ A;  1KUK A;  2OVX A;  4JPA A;  5CZM A;  2HU6 A;  1J7N A;  1FM1 A;  3AYK A;  3B92 A;  4QKZ A;  1JAP A;  4ZR5 A;  1A86 A;  1SMP A;  2PJT A;  2K2G A;  3P1V A;  3K7N A;  1ZVX A;  3VI1 A;  3F15 A;  1PWW A;  1Y93 A;  3F16 A;  3TS4 A;  2I47 A;  1BKC E;  1CK7 A;  3KEK A;  1OZ9 A;  4XM7 A;  1UTT A;  1D8M A;  1UEA A;  1XFZ A;  2E3X A;  2A8H A;  3F17 A;  4H30 A;  2WO9 A;  1PWU A;  1O0T A;  1RM8 A;  4WF6 A;  1B8Y A;  2V4B A;  2YUF A;  4I03 A;  1XFX A;  3DL1 A;  5H8X A;  4ON1 A;  4R3V A;  3DWB A;  1G4K A;  5L79 A;  3B2Z A;  2MZH A;  2N8R A;  2AIG P;  2DW1 A;  3O2X A;  3P24 A;  4H84 A;  1XFV A;  4L6T A;  3Q2G A;  3L0V A;  1D5J A;  5BOT A;  3K7L A;  1ZXV A;  1HOV A;  4WK7 A;  1BZS A;  3LIK A;  1XFY A;  1BKC A;  3DPE A;  1YCM A;  2OXW A;  3HBU P;  1C8T A;  5B5P A;  1R54 A;  3OHL A;  1BSW A;  1CAQ A;  1ZP5 A;  2J83 A;  1B3D A;  1DTH A;  5BOY A;  2W12 A;  3WV3 A;  1QJJ A;  2O3E A;  4Q1L A;  3KRY A;  2MZI A;  3L0T A;  3HB2 P;  966C A;  4H3X A;  1QUA A;  1KUI A;  4DPE A;  2OW2 A; 
#chains in the Genus database with same CATH homology
 4DD8 A;  1JAQ A;  1JK3 A;  3LEA A;  2RJP A;  3HDA P;  3KHI A;  4H1Q A;  1Q3A A;  3USN A;  1UTZ A;  1BKC I;  1MMQ A;  3HY7 A;  2DW0 A;  3LUN A;  1BQO A;  3TT4 A;  1BM6 A;  4L63 A;  4JIJ A;  1GE5 A;  3LKA A;  5D1T A;  1KUG A;  3LJZ A;  4H49 A;  3KWV C;  1JKY A;  2OXZ A;  2CLT A;  1I76 A;  3EHY A;  3N2V A;  4XBH A;  1BUV M;  3NX7 A;  1SLN A;  1IAB A;  3DTE A;  2JSD A;  1OM8 A;  1MMR A;  2OY2 A;  4GUY A;  5D3C A;  4XCT A;  4A3W A;  1BQQ M;  1IAC A;  2SRT A;  2MLR A;  1XFW A;  1GKC A;  2JIH A;  1EAK A;  2JNP A;  1AST A;  1H71 P;  4WKE A;  1ROS A;  1KBC A;  4CTH A;  1OM6 A;  2QPJ A;  3F18 A;  4L7A A;  4JA1 A;  1HFC A;  2X3B A;  2OW0 A;  5I12 A;  2X7M A;  1GE7 A;  1CIZ A;  4FVL A;  3KEJ A;  2XS3 A;  2Z2D A;  4WKI A;  1G49 A;  1OS9 A;  4IUW A;  1SLM A;  1KUF A;  4PKR A;  1HV5 A;  4DF9 A;  3TVC A;  2POJ A;  1JJ9 A;  4H82 A;  1FLS A;  4G0D A;  1KAP P;  3KMC A;  3KEC A;  1CXV A;  1S4B P;  2WO8 A;  4PKS A;  3RTS A;  4EFS A;  5LAB A;  1AKL A;  1ATL A;  1RMZ A;  2AYK A;  1QJI A;  2W15 A;  2ERQ A;  3RTT A;  1I1I P;  1JAO A;  2MZE A;  3LIL A;  4IN9 A;  4JP4 A;  1HFS A;  4GR8 A;  4G9L A;  4IJO A;  4PKQ A;  3DNG A;  1OO9 A;  1HY7 A;  1A85 A;  4GWM A;  1MMP A;  3CKI A;  1SU3 A;  3HYG A;  2XS4 A;  1YP1 A;  1MNC A;  2X3C A;  2L0R A;  1BIW A;  2WOA A;  2Y6C A;  1XUD A;  4GWN A;  4JQG A;  1OM7 A;  1ZXC A;  1R55 A;  1G12 A;  1R1I A;  3O64 A;  1KUH A;  1JIW P;  2ERO A;  1I73 A;  3OHO A;  1G05 A;  3LK8 A;  3EDZ A;  3KME A;  5I0L A;  1SAT A;  1Y0V A;  1JAN A;  1OMJ A;  5I3M A;  3EWJ A;  2RJQ A;  2O36 A;  1K7I A;  1ZTQ A;  1YQY A;  2OXU A;  3DSL A;  2D1N A;  3DTK A;  4AXQ A;  4WZV A;  3SHI A;  4DV8 A;  2E2D A;  3LUM A;  5L7F A;  2OY4 A;  2OW1 A;  4H2E A;  1ND1 A;  3N2U A;  1HTD A;  4L19 A;  3VTG A;  5BPA A;  1IAA A;  1JH1 A;  1IAE A;  3DTI A;  2FV9 A;  3LIR A;  4XM6 A;  1G9K A;  1EUB A;  1R1J A;  2K9C A;  5CXA A;  1QIA A;  2DDY A;  1WNI A;  1GXD A;  1C7K A;  2FV5 A;  3LGP A;  1XFU A;  5I43 A;  5CUH A;  3G5C A;  3LQ0 A;  1XUR A;  3HBV P;  4I35 A;  1C3I A;  1SRP A;  2YIG A;  1Y8J A;  1IAD A;  4FU4 A;  1GO8 P;  1K7Q A;  2DW2 A;  4GQL A;  3AIG A;  1ZS0 A;  2W14 A;  1MMB A;  3BA0 A;  2OI0 A;  1K7G A;  3B8Z A;  3EDH A;  1R1H A;  2YB9 A;  3LMC A;  1YOU A;  4HMA A;  3HDB A;  4PKT A;  3WV1 A;  2OW9 A;  2W0D A;  4XM8 A;  4ILW D;  3EDI A;  3HY9 A;  2CKI A;  2ERP A;  4PKU A;  4GR3 A;  3U1R A;  3ZUK A;  4HX3 A;  4H76 A;  456C A;  2JT6 A;  1GE6 A;  5D2B A;  3I7G A;  5I4O A;  3LJG A;  2OVZ A;  4A7B A;  1IAG A;  2MLS A;  3Q2H A;  3EHX A;  3UVC A;  5JMY A;  2X3A A;  3DPF A;  1D7X A;  4FXQ A;  3EDG A;  3GBO A;  3F1A A;  4GR0 A;  4AYK A;  1DMT A;  3G42 A;  1O0Q A;  4GF1 A;  5D1U A;  4AUO A;  2Y6D A;  3I7I A;  3MA2 A;  2TCL A;  3LE9 A;  5I2Z A;  3AYU A;  2JT5 A;  3ELM A;  1CGL A;  1PWQ A;  3LJT A;  3WV2 A;  2J0T A;  1GKD A;  3F19 A;  1AF0 A;  1PWV A;  3ZVS A;  1D8F A;  1QIB A;  4PKV A;  3E8R A;  1CGF A;  1FBL A;  1GO7 P;  4J4M A;  2DDF A;  3TSK A;  5D1S A;  2USN A;  1PWP A;  1JIZ A;  1XUC A;  1UMS A;  3ZXH A;  4PKW A;  4FXY P;  1CGE A;  1CQR A;  1L6J A;  5D7W A;  2W13 A;  3V96 B;  3LQB A;  1BUD A;  1QIC A;  1USN A;  4AIG A;  2OZR A;  1EB6 A;  830C A;  1OS2 A;  2D1O A;  1UMT A;  1Z3J A;  5B5O A;  1AYK A;  2KRJ A;  1KUK A;  2OVX A;  4JPA A;  5CZM A;  2HU6 A;  1J7N A;  1FM1 A;  3AYK A;  3B92 A;  4QKZ A;  1JAP A;  4ZR5 A;  1A86 A;  1SMP A;  2PJT A;  2K2G A;  3P1V A;  3K7N A;  1ZVX A;  3VI1 A;  3F15 A;  1PWW A;  1Y93 A;  3F16 A;  3TS4 A;  2I47 A;  1BKC E;  1CK7 A;  3KEK A;  4XM7 A;  1UTT A;  1D8M A;  1UEA A;  1XFZ A;  2E3X A;  2A8H A;  3F17 A;  4H30 A;  2WO9 A;  1PWU A;  1O0T A;  1RM8 A;  4WF6 A;  1B8Y A;  2V4B A;  2YUF A;  4I03 A;  1XFX A;  3DL1 A;  5H8X A;  4ON1 A;  4R3V A;  3DWB A;  1G4K A;  5L79 A;  3B2Z A;  2MZH A;  2N8R A;  2AIG P;  2DW1 A;  3O2X A;  3P24 A;  4H84 A;  1XFV A;  4L6T A;  3Q2G A;  3L0V A;  1D5J A;  5BOT A;  3K7L A;  1ZXV A;  1HOV A;  4WK7 A;  1BZS A;  3LIK A;  1XFY A;  1BKC A;  3DPE A;  1YCM A;  2OXW A;  3HBU P;  1C8T A;  5B5P A;  1R54 A;  3OHL A;  1BSW A;  1CAQ A;  1ZP5 A;  2J83 A;  1B3D A;  1DTH A;  5BOY A;  2W12 A;  3WV3 A;  1QJJ A;  2O3E A;  4Q1L A;  3KRY A;  2MZI A;  3L0T A;  3HB2 P;  966C A;  4H3X A;  1QUA A;  1KUI A;  4DPE A;  2OW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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