3BDFA

Crystal structure of metal-free e. coli alkaline phosphatase (t155v)
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
434
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdfA00
1ZEDA 4YR1A 4CYRA 4UPIA 4UOPA 3BDHA 1N2LA 3LXQA 4LR2A 2RH6A 3M8ZA 3UNYA 2IUCB 2W5RA 5IJQA 2XR9A 5HRTA 3KD8A 1ELXA 3UN3A 3ED4A 5INHA 1KHNA 3A52A 4GTWA 2ZKTA 2W8DA 3M8WA 4KJDA 1ED8A 4ZG6A 1EI6A 3TX0A 2GLQA 3NKRA 1HQAA 1E3CP 4LRDA 4GTYA 1E1ZP 1KH4A 1ED9A 3TWZA 3M8YA 4LREA 1URAA 3IDDA 1AJBA 4ZG9A 1EJJA 4MY4A 1ELYA 3Q3QA 3M7VA 1HDHA 1K7HA 3SZYA 4CXKA 1AUKA 1ANIA 3E2DA 2QZUA 1AJAA 4GTXA 1O98A 4FDJA 3NKPA 1ZEBA 3T01A 3TG0A 1KHKA 5EGEA 1AJCA 3WAWA 1URBA 5DLWA 5C66A 1E2SP 4KM4A 3UO0A 4UPKA 5DLTA 3DYCA 2VQRA 5L0BA 3BDGA 4CYSA 1Y6VA 4LRBA 1ALIA 3DPCA 1EW2A 4LRCA 3IGZB 4TN0A 5GOVA 1KHLA 4KAYA 2W5SA 5TJ3A 5LRMA 1N2KA 5EGHA 5DLVA 3T02A 3T00A 4KJGA 1ALJA 1Y7AA 4UPLA 3IGYB 2GA3A 4N7TA 3NKMA 3WAYA 3SZZA 2D1GA 1ZEFA 5LQQA 2GSOA 1B8JA 3NVLA 1SHNA 2IUCA 3WAXA 4ZGAA 1KH5A 2W5XA 1ANJA 5L0KA 1P49A 4CXUA 3UN2A 3UN5A 4LQYA 1HJKA 5LIAA 5AJ9A 2ANHA 3NKNA 3NKOA 4MHXA 3CMRA 4GTZA 2W8SA 1AJDA 2GSUA 3B5QA 3WBHA 5KXAA 1O99A 4FDIA 5IJSA 2GSNA 4LR8A 3WAVA 1EW9A 4MIVA 2W5TA 4NWJA 4B56A 2IFYA 2XRGA 3MK0A 3BDFA 1ALKA 1SHQA 3NKQA 4UPHA 5GRRA 3MK1A 4LR7A 4UORA 3MK2A 4ZG7A 1KH9A 5LRNA 2X98A 4QAXA 2W5VA 4LRFA 2W5QA 3BDGB 1ALHA 3OT9A 1EQJA 4LR9A 4NWXA 2W5WA 1E33P 5L0EA 1EW8A 1FSUA 2G9YA 1ELZA 4UOOA 5K4PA 4CXSA 1KH7A 1KHJA 4LRAA 4KAVA
chains in the Genus database with same CATH superfamily
1ZEDA 4YR1A 4CYRA 4UPIA 4UOPA 3BDHA 1N2LA 3LXQA 4LR2A 2RH6A 3M8ZA 3UNYA 2IUCB 2W5RA 5IJQA 2XR9A 5HRTA 3KD8A 1ELXA 3UN3A 3ED4A 5INHA 1KHNA 3A52A 4GTWA 2ZKTA 2W8DA 3M8WA 4KJDA 1ED8A 4ZG6A 1EI6A 3TX0A 2GLQA 3NKRA 1HQAA 1E3CP 4LRDA 4GTYA 1E1ZP 1KH4A 1ED9A 3TWZA 3M8YA 4LREA 1URAA 3IDDA 1AJBA 4ZG9A 1EJJA 4MY4A 1ELYA 3Q3QA 3M7VA 1HDHA 1K7HA 3SZYA 4CXKA 1AUKA 1ANIA 3E2DA 2QZUA 1AJAA 4GTXA 1O98A 4FDJA 3NKPA 1ZEBA 3T01A 3TG0A 1KHKA 5EGEA 1AJCA 3WAWA 1URBA 5DLWA 5C66A 1E2SP 4KM4A 3UO0A 4UPKA 5DLTA 3DYCA 2VQRA 5L0BA 3BDGA 4CYSA 1Y6VA 4LRBA 1ALIA 3DPCA 1EW2A 4LRCA 3IGZB 4TN0A 5GOVA 1KHLA 4KAYA 2W5SA 5TJ3A 5LRMA 1N2KA 5EGHA 5DLVA 3T02A 3T00A 4KJGA 1ALJA 1Y7AA 4UPLA 3IGYB 2GA3A 4N7TA 3NKMA 3WAYA 3SZZA 2D1GA 1ZEFA 5LQQA 2GSOA 1B8JA 3NVLA 1SHNA 2IUCA 3WAXA 4ZGAA 1KH5A 2W5XA 1ANJA 5L0KA 1P49A 4CXUA 3UN2A 3UN5A 4LQYA 1HJKA 5LIAA 5AJ9A 2ANHA 3NKNA 3NKOA 4MHXA 3CMRA 4GTZA 2W8SA 1AJDA 2GSUA 3B5QA 3WBHA 5KXAA 1O99A 4FDIA 5IJSA 2GSNA 4LR8A 3WAVA 1EW9A 4MIVA 2W5TA 4NWJA 4B56A 2IFYA 2XRGA 3MK0A 3BDFA 1ALKA 1SHQA 3NKQA 4UPHA 5GRRA 3MK1A 4LR7A 4UORA 3MK2A 4ZG7A 1KH9A 5LRNA 2X98A 4QAXA 2W5VA 4LRFA 2W5QA 3BDGB 1ALHA 3OT9A 1EQJA 4LR9A 4NWXA 2W5WA 1E33P 5L0EA 1EW8A 1FSUA 2G9YA 1ELZA 4UOOA 5K4PA 4CXSA 1KH7A 1KHJA 4LRAA 4KAVA
chains in the Genus database with same CATH topology
1ZEDA 4YR1A 4CYRA 4UPIA 4UOPA 3BDHA 1N2LA 3LXQA 4LR2A 2RH6A 3M8ZA 3UNYA 2IUCB 2W5RA 5IJQA 2XR9A 5HRTA 3KD8A 1ELXA 3UN3A 3ED4A 5INHA 1KHNA 3A52A 4GTWA 2ZKTA 2W8DA 3M8WA 4KJDA 1ED8A 4ZG6A 1EI6A 3TX0A 2GLQA 3NKRA 1HQAA 1E3CP 4LRDA 4GTYA 1E1ZP 1KH4A 1ED9A 3TWZA 3M8YA 4LREA 1URAA 3IDDA 1AJBA 4ZG9A 1EJJA 4MY4A 1ELYA 3Q3QA 3M7VA 1HDHA 1K7HA 3SZYA 4CXKA 1AUKA 1ANIA 3E2DA 2QZUA 1AJAA 4GTXA 1O98A 4FDJA 3NKPA 1ZEBA 3T01A 3TG0A 1KHKA 5EGEA 1AJCA 3WAWA 1URBA 5DLWA 5C66A 1E2SP 4KM4A 3UO0A 4UPKA 5DLTA 3DYCA 2VQRA 5L0BA 3BDGA 4CYSA 1Y6VA 4LRBA 1ALIA 3DPCA 1EW2A 4LRCA 3IGZB 4TN0A 5GOVA 1KHLA 4KAYA 2W5SA 5TJ3A 5LRMA 1N2KA 5EGHA 5DLVA 3T02A 3T00A 4KJGA 1ALJA 1Y7AA 4UPLA 3IGYB 2GA3A 4N7TA 3NKMA 3WAYA 3SZZA 2D1GA 1ZEFA 5LQQA 2GSOA 1B8JA 3NVLA 1SHNA 2IUCA 3WAXA 4ZGAA 1KH5A 2W5XA 1ANJA 5L0KA 1P49A 4CXUA 3UN2A 3UN5A 4LQYA 1HJKA 5LIAA 5AJ9A 2ANHA 3NKNA 3NKOA 4MHXA 3CMRA 4GTZA 2W8SA 1AJDA 2GSUA 3B5QA 3WBHA 5KXAA 1O99A 4FDIA 5IJSA 2GSNA 4LR8A 3WAVA 1EW9A 4MIVA 2W5TA 4NWJA 4B56A 2IFYA 2XRGA 3MK0A 3BDFA 1ALKA 1SHQA 3NKQA 4UPHA 5GRRA 3MK1A 4LR7A 4UORA 3MK2A 4ZG7A 1KH9A 5LRNA 2X98A 4QAXA 2W5VA 4LRFA 2W5QA 3BDGB 1ALHA 3OT9A 1EQJA 4LR9A 4NWXA 2W5WA 1E33P 5L0EA 1EW8A 1FSUA 2G9YA 1ELZA 4UOOA 5K4PA 4CXSA 1KH7A 1KHJA 4LRAA 4KAVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZED A;  4YR1 A;  4CYR A;  4UPI A;  4UOP A;  3BDH A;  1N2L A;  3LXQ A;  4LR2 A;  2RH6 A;  3M8Z A;  3UNY A;  2IUC B;  2W5R A;  5IJQ A;  2XR9 A;  5HRT A;  3KD8 A;  1ELX A;  3UN3 A;  3ED4 A;  5INH A;  1KHN A;  3A52 A;  4GTW A;  2ZKT A;  2W8D A;  3M8W A;  4KJD A;  1ED8 A;  4ZG6 A;  1EI6 A;  3TX0 A;  2GLQ A;  3NKR A;  1HQA A;  1E3C P;  4LRD A;  4GTY A;  1E1Z P;  1KH4 A;  1ED9 A;  3TWZ A;  3M8Y A;  4LRE A;  1URA A;  3IDD A;  1AJB A;  4ZG9 A;  1EJJ A;  4MY4 A;  1ELY A;  3Q3Q A;  3M7V A;  1HDH A;  1K7H A;  3SZY A;  4CXK A;  1AUK A;  1ANI A;  3E2D A;  2QZU A;  1AJA A;  4GTX A;  1O98 A;  4FDJ A;  3NKP A;  1ZEB A;  3T01 A;  3TG0 A;  1KHK A;  5EGE A;  1AJC A;  3WAW A;  1URB A;  5DLW A;  5C66 A;  1E2S P;  4KM4 A;  3UO0 A;  4UPK A;  5DLT A;  3DYC A;  2VQR A;  5L0B A;  3BDG A;  4CYS A;  1Y6V A;  4LRB A;  1ALI A;  3DPC A;  1EW2 A;  4LRC A;  3IGZ B;  4TN0 A;  5GOV A;  1KHL A;  4KAY A;  2W5S A;  5TJ3 A;  5LRM A;  1N2K A;  5EGH A;  5DLV A;  3T02 A;  3T00 A;  4KJG A;  1ALJ A;  1Y7A A;  4UPL A;  3IGY B;  2GA3 A;  4N7T A;  3NKM A;  3WAY A;  3SZZ A;  2D1G A;  1ZEF A;  5LQQ A;  2GSO A;  1B8J A;  3NVL A;  1SHN A;  2IUC A;  3WAX A;  4ZGA A;  1KH5 A;  2W5X A;  1ANJ A;  5L0K A;  1P49 A;  4CXU A;  3UN2 A;  3UN5 A;  4LQY A;  1HJK A;  5LIA A;  5AJ9 A;  2ANH A;  3NKN A;  3NKO A;  4MHX A;  3CMR A;  4GTZ A;  2W8S A;  1AJD A;  2GSU A;  3B5Q A;  3WBH A;  5KXA A;  1O99 A;  4FDI A;  5IJS A;  2GSN A;  4LR8 A;  3WAV A;  1EW9 A;  4MIV A;  2W5T A;  4NWJ A;  4B56 A;  2IFY A;  2XRG A;  3MK0 A;  3BDF A;  1ALK A;  1SHQ A;  3NKQ A;  4UPH A;  5GRR A;  3MK1 A;  4LR7 A;  4UOR A;  3MK2 A;  4ZG7 A;  1KH9 A;  5LRN A;  2X98 A;  4QAX A;  2W5V A;  4LRF A;  2W5Q A;  3BDG B;  1ALH A;  3OT9 A;  1EQJ A;  4LR9 A;  4NWX A;  2W5W A;  1E33 P;  5L0E A;  1EW8 A;  1FSU A;  2G9Y A;  1ELZ A;  4UOO A;  5K4P A;  4CXS A;  1KH7 A;  1KHJ A;  4LRA A;  4KAV A; 
#chains in the Genus database with same CATH topology
 1ZED A;  4YR1 A;  4CYR A;  4UPI A;  4UOP A;  3BDH A;  1N2L A;  3LXQ A;  4LR2 A;  2RH6 A;  3M8Z A;  3UNY A;  2IUC B;  2W5R A;  5IJQ A;  2XR9 A;  5HRT A;  3KD8 A;  1ELX A;  3UN3 A;  3ED4 A;  5INH A;  1KHN A;  3A52 A;  4GTW A;  2ZKT A;  2W8D A;  3M8W A;  4KJD A;  1ED8 A;  4ZG6 A;  1EI6 A;  3TX0 A;  2GLQ A;  3NKR A;  1HQA A;  1E3C P;  4LRD A;  4GTY A;  1E1Z P;  1KH4 A;  1ED9 A;  3TWZ A;  3M8Y A;  4LRE A;  1URA A;  3IDD A;  1AJB A;  4ZG9 A;  1EJJ A;  4MY4 A;  1ELY A;  3Q3Q A;  3M7V A;  1HDH A;  1K7H A;  3SZY A;  4CXK A;  1AUK A;  1ANI A;  3E2D A;  2QZU A;  1AJA A;  4GTX A;  1O98 A;  4FDJ A;  3NKP A;  1ZEB A;  3T01 A;  3TG0 A;  1KHK A;  5EGE A;  1AJC A;  3WAW A;  1URB A;  5DLW A;  5C66 A;  1E2S P;  4KM4 A;  3UO0 A;  4UPK A;  5DLT A;  3DYC A;  2VQR A;  5L0B A;  3BDG A;  4CYS A;  1Y6V A;  4LRB A;  1ALI A;  3DPC A;  1EW2 A;  4LRC A;  3IGZ B;  4TN0 A;  5GOV A;  1KHL A;  4KAY A;  2W5S A;  5TJ3 A;  5LRM A;  1N2K A;  5EGH A;  5DLV A;  3T02 A;  3T00 A;  4KJG A;  1ALJ A;  1Y7A A;  4UPL A;  3IGY B;  2GA3 A;  4N7T A;  3NKM A;  3WAY A;  3SZZ A;  2D1G A;  1ZEF A;  5LQQ A;  2GSO A;  1B8J A;  3NVL A;  1SHN A;  2IUC A;  3WAX A;  4ZGA A;  1KH5 A;  2W5X A;  1ANJ A;  5L0K A;  1P49 A;  4CXU A;  3UN2 A;  3UN5 A;  4LQY A;  1HJK A;  5LIA A;  5AJ9 A;  2ANH A;  3NKN A;  3NKO A;  4MHX A;  3CMR A;  4GTZ A;  2W8S A;  1AJD A;  2GSU A;  3B5Q A;  3WBH A;  5KXA A;  1O99 A;  4FDI A;  5IJS A;  2GSN A;  4LR8 A;  3WAV A;  1EW9 A;  4MIV A;  2W5T A;  4NWJ A;  4B56 A;  2IFY A;  2XRG A;  3MK0 A;  3BDF A;  1ALK A;  1SHQ A;  3NKQ A;  4UPH A;  5GRR A;  3MK1 A;  4LR7 A;  4UOR A;  3MK2 A;  4ZG7 A;  1KH9 A;  5LRN A;  2X98 A;  4QAX A;  2W5V A;  4LRF A;  2W5Q A;  3BDG B;  1ALH A;  3OT9 A;  1EQJ A;  4LR9 A;  4NWX A;  2W5W A;  1E33 P;  5L0E A;  1EW8 A;  1FSU A;  2G9Y A;  1ELZ A;  4UOO A;  5K4P A;  4CXS A;  1KH7 A;  1KHJ A;  4LRA A;  4KAV A; 
#chains in the Genus database with same CATH homology
 1ZED A;  4YR1 A;  4CYR A;  4UPI A;  4UOP A;  3BDH A;  1N2L A;  3LXQ A;  4LR2 A;  2RH6 A;  3M8Z A;  3UNY A;  2IUC B;  2W5R A;  5IJQ A;  2XR9 A;  5HRT A;  3KD8 A;  1ELX A;  3UN3 A;  3ED4 A;  5INH A;  1KHN A;  3A52 A;  4GTW A;  2ZKT A;  2W8D A;  3M8W A;  4KJD A;  1ED8 A;  4ZG6 A;  1EI6 A;  3TX0 A;  2GLQ A;  3NKR A;  1HQA A;  1E3C P;  4LRD A;  4GTY A;  1E1Z P;  1KH4 A;  1ED9 A;  3TWZ A;  3M8Y A;  4LRE A;  1URA A;  3IDD A;  1AJB A;  4ZG9 A;  1EJJ A;  4MY4 A;  1ELY A;  3Q3Q A;  3M7V A;  1HDH A;  1K7H A;  3SZY A;  4CXK A;  1AUK A;  1ANI A;  3E2D A;  2QZU A;  1AJA A;  4GTX A;  1O98 A;  4FDJ A;  3NKP A;  1ZEB A;  3T01 A;  3TG0 A;  1KHK A;  5EGE A;  1AJC A;  3WAW A;  1URB A;  5DLW A;  5C66 A;  1E2S P;  4KM4 A;  3UO0 A;  4UPK A;  5DLT A;  3DYC A;  2VQR A;  5L0B A;  3BDG A;  4CYS A;  1Y6V A;  4LRB A;  1ALI A;  3DPC A;  1EW2 A;  4LRC A;  3IGZ B;  4TN0 A;  5GOV A;  1KHL A;  4KAY A;  2W5S A;  5TJ3 A;  5LRM A;  1N2K A;  5EGH A;  5DLV A;  3T02 A;  3T00 A;  4KJG A;  1ALJ A;  1Y7A A;  4UPL A;  3IGY B;  2GA3 A;  4N7T A;  3NKM A;  3WAY A;  3SZZ A;  2D1G A;  1ZEF A;  5LQQ A;  2GSO A;  1B8J A;  3NVL A;  1SHN A;  2IUC A;  3WAX A;  4ZGA A;  1KH5 A;  2W5X A;  1ANJ A;  5L0K A;  1P49 A;  4CXU A;  3UN2 A;  3UN5 A;  4LQY A;  1HJK A;  5LIA A;  5AJ9 A;  2ANH A;  3NKN A;  3NKO A;  4MHX A;  3CMR A;  4GTZ A;  2W8S A;  1AJD A;  2GSU A;  3B5Q A;  3WBH A;  5KXA A;  1O99 A;  4FDI A;  5IJS A;  2GSN A;  4LR8 A;  3WAV A;  1EW9 A;  4MIV A;  2W5T A;  4NWJ A;  4B56 A;  2IFY A;  2XRG A;  3MK0 A;  3BDF A;  1ALK A;  1SHQ A;  3NKQ A;  4UPH A;  5GRR A;  3MK1 A;  4LR7 A;  4UOR A;  3MK2 A;  4ZG7 A;  1KH9 A;  5LRN A;  2X98 A;  4QAX A;  2W5V A;  4LRF A;  2W5Q A;  3BDG B;  1ALH A;  3OT9 A;  1EQJ A;  4LR9 A;  4NWX A;  2W5W A;  1E33 P;  5L0E A;  1EW8 A;  1FSU A;  2G9Y A;  1ELZ A;  4UOO A;  5K4P A;  4CXS A;  1KH7 A;  1KHJ A;  4LRA A;  4KAV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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