3BDFA

Crystal structure of metal-free e. coli alkaline phosphatase (t155v)
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
434
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdfA00
1EW2A 4ZGAA 2W5RA 4KJGA 2W5TA 5DLWA 5DLTA 2W5QA 2W8SA 3TX0A 1EW8A 3M8WA 4GTXA 3Q3QA 1ZEBA 4CXUA 3T01A 3M7VA 1B8JA 3ED4A 4LRBA 1E3CP 1URAA 5K4PA 3TG0A 4MIVA 2VQRA 3UN3A 5IJSA 3E2DA 2QZUA 4KJDA 4LRCA 3DPCA 4UOOA 3SZYA 3WAWA 3UN5A 1ELZA 3BDFA 4LRDA 3UNYA 1ELXA 4GTYA 1AJCA 4KAYA 2GA3A 3NKMA 3WAXA 5L0KA 3M8ZA 1KH7A 1URBA 3NKQA 4ZG7A 4LR2A 1O99A 4LREA 2X98A 5LRMA 1ALHA 1N2KA 1Y7AA 3NVLA 1KHNA 4N7TA 5LQQA 5KXAA 4CXSA 4B56A 2W5VA 3MK0A 4UOPA 5GOVA 1ANIA 2IUCA 4LRAA 3IGYB 1KH5A 4CYSA 2ANHA 2XR9A 3BDGB 3IDDA 4GTWA 4FDIA 1AUKA 4LR7A 1K7HA 1ALKA 5LIAA 1E2SP 4UPIA 4UPKA 1FSUA 4FDJA 4QAXA 2IFYA 3NKRA 1ANJA 1SHNA 2GLQA 4LR9A 3BDHA 5C66A 3CMRA 4ZG9A 2W5SA 1AJDA 1KHJA 2W5WA 2XRGA 5EGHA 1HDHA 4TN0A 1KHKA 4MHXA 2GSOA 4ZG6A 5AJ9A 1ZEFA 1ED8A 4MY4A 2GSNA 5HRTA 1AJAA 5TJ3A 1N2LA 3MK2A 3WBHA 2W5XA 3KD8A 3UN2A 3T02A 4YR1A 5EGEA 1ZEDA 3DYCA 3OT9A 2D1GA 3LXQA 4NWJA 5DLVA 1ALJA 1AJBA 4UPHA 1P49A 5L0EA 1EW9A 1E33P 2G9YA 3MK1A 1ALIA 4LRFA 3M8YA 1EQJA 3BDGA 4UORA 3NKNA 3NKPA 4KAVA 4CYRA 5LRNA 3A52A 1ED9A 4LQYA 3T00A 4LR8A 3WAYA 5GRRA 1EI6A 1O98A 1E1ZP 5L0BA 1EJJA 1HQAA 3IGZB 3TWZA 1KH4A 2RH6A 2W8DA 5INHA 3UO0A 1Y6VA 3B5QA 2ZKTA 5IJQA 3WAVA 1ELYA 4CXKA 1HJKA 3SZZA 2GSUA 1KH9A 1KHLA 3NKOA 4NWXA 4GTZA 4KM4A 2IUCB 1SHQA 4UPLA
chains in the Genus database with same CATH superfamily
1EW2A 4ZGAA 2W5RA 4KJGA 2W5TA 5DLWA 5DLTA 2W5QA 2W8SA 3TX0A 1EW8A 3M8WA 4GTXA 3Q3QA 1ZEBA 4CXUA 3T01A 3M7VA 1B8JA 3ED4A 4LRBA 1E3CP 1URAA 5K4PA 3TG0A 4MIVA 2VQRA 3UN3A 5IJSA 3E2DA 2QZUA 4KJDA 4LRCA 3DPCA 4UOOA 3SZYA 3WAWA 3UN5A 1ELZA 3BDFA 4LRDA 3UNYA 1ELXA 4GTYA 1AJCA 4KAYA 2GA3A 3NKMA 3WAXA 5L0KA 3M8ZA 1KH7A 1URBA 3NKQA 4ZG7A 4LR2A 1O99A 4LREA 2X98A 5LRMA 1ALHA 1N2KA 1Y7AA 3NVLA 1KHNA 4N7TA 5LQQA 5KXAA 4CXSA 4B56A 2W5VA 3MK0A 4UOPA 5GOVA 1ANIA 2IUCA 4LRAA 3IGYB 1KH5A 4CYSA 2ANHA 2XR9A 3BDGB 3IDDA 4GTWA 4FDIA 1AUKA 4LR7A 1K7HA 1ALKA 5LIAA 1E2SP 4UPIA 4UPKA 1FSUA 4FDJA 4QAXA 2IFYA 3NKRA 1ANJA 1SHNA 2GLQA 4LR9A 3BDHA 5C66A 3CMRA 4ZG9A 2W5SA 1AJDA 1KHJA 2W5WA 2XRGA 5EGHA 1HDHA 4TN0A 1KHKA 4MHXA 2GSOA 4ZG6A 5AJ9A 1ZEFA 1ED8A 4MY4A 2GSNA 5HRTA 1AJAA 5TJ3A 1N2LA 3MK2A 3WBHA 2W5XA 3KD8A 3UN2A 3T02A 4YR1A 5EGEA 1ZEDA 3DYCA 3OT9A 2D1GA 3LXQA 4NWJA 5DLVA 1ALJA 1AJBA 4UPHA 1P49A 5L0EA 1EW9A 1E33P 2G9YA 3MK1A 1ALIA 4LRFA 3M8YA 1EQJA 3BDGA 4UORA 3NKNA 3NKPA 4KAVA 4CYRA 5LRNA 3A52A 1ED9A 4LQYA 3T00A 4LR8A 3WAYA 5GRRA 1EI6A 1O98A 1E1ZP 5L0BA 1EJJA 1HQAA 3IGZB 3TWZA 1KH4A 2RH6A 2W8DA 5INHA 3UO0A 1Y6VA 3B5QA 2ZKTA 5IJQA 3WAVA 1ELYA 4CXKA 1HJKA 3SZZA 2GSUA 1KH9A 1KHLA 3NKOA 4NWXA 4GTZA 4KM4A 2IUCB 1SHQA 4UPLA
chains in the Genus database with same CATH topology
1EW2A 4ZGAA 2W5RA 4KJGA 2W5TA 5DLWA 5DLTA 2W5QA 2W8SA 3TX0A 1EW8A 3M8WA 4GTXA 3Q3QA 1ZEBA 4CXUA 3T01A 3M7VA 1B8JA 3ED4A 4LRBA 1E3CP 1URAA 5K4PA 3TG0A 4MIVA 2VQRA 3UN3A 5IJSA 3E2DA 2QZUA 4KJDA 4LRCA 3DPCA 4UOOA 3SZYA 3WAWA 3UN5A 1ELZA 3BDFA 4LRDA 3UNYA 1ELXA 4GTYA 1AJCA 4KAYA 2GA3A 3NKMA 3WAXA 5L0KA 3M8ZA 1KH7A 1URBA 3NKQA 4ZG7A 4LR2A 1O99A 4LREA 2X98A 5LRMA 1ALHA 1N2KA 1Y7AA 3NVLA 1KHNA 4N7TA 5LQQA 5KXAA 4CXSA 4B56A 2W5VA 3MK0A 4UOPA 5GOVA 1ANIA 2IUCA 4LRAA 3IGYB 1KH5A 4CYSA 2ANHA 2XR9A 3BDGB 3IDDA 4GTWA 4FDIA 1AUKA 4LR7A 1K7HA 1ALKA 5LIAA 1E2SP 4UPIA 4UPKA 1FSUA 4FDJA 4QAXA 2IFYA 3NKRA 1ANJA 1SHNA 2GLQA 4LR9A 3BDHA 5C66A 3CMRA 4ZG9A 2W5SA 1AJDA 1KHJA 2W5WA 2XRGA 5EGHA 1HDHA 4TN0A 1KHKA 4MHXA 2GSOA 4ZG6A 5AJ9A 1ZEFA 1ED8A 4MY4A 2GSNA 5HRTA 1AJAA 5TJ3A 1N2LA 3MK2A 3WBHA 2W5XA 3KD8A 3UN2A 3T02A 4YR1A 5EGEA 1ZEDA 3DYCA 3OT9A 2D1GA 3LXQA 4NWJA 5DLVA 1ALJA 1AJBA 4UPHA 1P49A 5L0EA 1EW9A 1E33P 2G9YA 3MK1A 1ALIA 4LRFA 3M8YA 1EQJA 3BDGA 4UORA 3NKNA 3NKPA 4KAVA 4CYRA 5LRNA 3A52A 1ED9A 4LQYA 3T00A 4LR8A 3WAYA 5GRRA 1EI6A 1O98A 1E1ZP 5L0BA 1EJJA 1HQAA 3IGZB 3TWZA 1KH4A 2RH6A 2W8DA 5INHA 3UO0A 1Y6VA 3B5QA 2ZKTA 5IJQA 3WAVA 1ELYA 4CXKA 1HJKA 3SZZA 2GSUA 1KH9A 1KHLA 3NKOA 4NWXA 4GTZA 4KM4A 2IUCB 1SHQA 4UPLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EW2 A;  4ZGA A;  2W5R A;  4KJG A;  2W5T A;  5DLW A;  5DLT A;  2W5Q A;  2W8S A;  3TX0 A;  1EW8 A;  3M8W A;  4GTX A;  3Q3Q A;  1ZEB A;  4CXU A;  3T01 A;  3M7V A;  1B8J A;  3ED4 A;  4LRB A;  1E3C P;  1URA A;  5K4P A;  3TG0 A;  4MIV A;  2VQR A;  3UN3 A;  5IJS A;  3E2D A;  2QZU A;  4KJD A;  4LRC A;  3DPC A;  4UOO A;  3SZY A;  3WAW A;  3UN5 A;  1ELZ A;  3BDF A;  4LRD A;  3UNY A;  1ELX A;  4GTY A;  1AJC A;  4KAY A;  2GA3 A;  3NKM A;  3WAX A;  5L0K A;  3M8Z A;  1KH7 A;  1URB A;  3NKQ A;  4ZG7 A;  4LR2 A;  1O99 A;  4LRE A;  2X98 A;  5LRM A;  1ALH A;  1N2K A;  1Y7A A;  3NVL A;  1KHN A;  4N7T A;  5LQQ A;  5KXA A;  4CXS A;  4B56 A;  2W5V A;  3MK0 A;  4UOP A;  5GOV A;  1ANI A;  2IUC A;  4LRA A;  3IGY B;  1KH5 A;  4CYS A;  2ANH A;  2XR9 A;  3BDG B;  3IDD A;  4GTW A;  4FDI A;  1AUK A;  4LR7 A;  1K7H A;  1ALK A;  5LIA A;  1E2S P;  4UPI A;  4UPK A;  1FSU A;  4FDJ A;  4QAX A;  2IFY A;  3NKR A;  1ANJ A;  1SHN A;  2GLQ A;  4LR9 A;  3BDH A;  5C66 A;  3CMR A;  4ZG9 A;  2W5S A;  1AJD A;  1KHJ A;  2W5W A;  2XRG A;  5EGH A;  1HDH A;  4TN0 A;  1KHK A;  4MHX A;  2GSO A;  4ZG6 A;  5AJ9 A;  1ZEF A;  1ED8 A;  4MY4 A;  2GSN A;  5HRT A;  1AJA A;  5TJ3 A;  1N2L A;  3MK2 A;  3WBH A;  2W5X A;  3KD8 A;  3UN2 A;  3T02 A;  4YR1 A;  5EGE A;  1ZED A;  3DYC A;  3OT9 A;  2D1G A;  3LXQ A;  4NWJ A;  5DLV A;  1ALJ A;  1AJB A;  4UPH A;  1P49 A;  5L0E A;  1EW9 A;  1E33 P;  2G9Y A;  3MK1 A;  1ALI A;  4LRF A;  3M8Y A;  1EQJ A;  3BDG A;  4UOR A;  3NKN A;  3NKP A;  4KAV A;  4CYR A;  5LRN A;  3A52 A;  1ED9 A;  4LQY A;  3T00 A;  4LR8 A;  3WAY A;  5GRR A;  1EI6 A;  1O98 A;  1E1Z P;  5L0B A;  1EJJ A;  1HQA A;  3IGZ B;  3TWZ A;  1KH4 A;  2RH6 A;  2W8D A;  5INH A;  3UO0 A;  1Y6V A;  3B5Q A;  2ZKT A;  5IJQ A;  3WAV A;  1ELY A;  4CXK A;  1HJK A;  3SZZ A;  2GSU A;  1KH9 A;  1KHL A;  3NKO A;  4NWX A;  4GTZ A;  4KM4 A;  2IUC B;  1SHQ A;  4UPL A; 
#chains in the Genus database with same CATH topology
 1EW2 A;  4ZGA A;  2W5R A;  4KJG A;  2W5T A;  5DLW A;  5DLT A;  2W5Q A;  2W8S A;  3TX0 A;  1EW8 A;  3M8W A;  4GTX A;  3Q3Q A;  1ZEB A;  4CXU A;  3T01 A;  3M7V A;  1B8J A;  3ED4 A;  4LRB A;  1E3C P;  1URA A;  5K4P A;  3TG0 A;  4MIV A;  2VQR A;  3UN3 A;  5IJS A;  3E2D A;  2QZU A;  4KJD A;  4LRC A;  3DPC A;  4UOO A;  3SZY A;  3WAW A;  3UN5 A;  1ELZ A;  3BDF A;  4LRD A;  3UNY A;  1ELX A;  4GTY A;  1AJC A;  4KAY A;  2GA3 A;  3NKM A;  3WAX A;  5L0K A;  3M8Z A;  1KH7 A;  1URB A;  3NKQ A;  4ZG7 A;  4LR2 A;  1O99 A;  4LRE A;  2X98 A;  5LRM A;  1ALH A;  1N2K A;  1Y7A A;  3NVL A;  1KHN A;  4N7T A;  5LQQ A;  5KXA A;  4CXS A;  4B56 A;  2W5V A;  3MK0 A;  4UOP A;  5GOV A;  1ANI A;  2IUC A;  4LRA A;  3IGY B;  1KH5 A;  4CYS A;  2ANH A;  2XR9 A;  3BDG B;  3IDD A;  4GTW A;  4FDI A;  1AUK A;  4LR7 A;  1K7H A;  1ALK A;  5LIA A;  1E2S P;  4UPI A;  4UPK A;  1FSU A;  4FDJ A;  4QAX A;  2IFY A;  3NKR A;  1ANJ A;  1SHN A;  2GLQ A;  4LR9 A;  3BDH A;  5C66 A;  3CMR A;  4ZG9 A;  2W5S A;  1AJD A;  1KHJ A;  2W5W A;  2XRG A;  5EGH A;  1HDH A;  4TN0 A;  1KHK A;  4MHX A;  2GSO A;  4ZG6 A;  5AJ9 A;  1ZEF A;  1ED8 A;  4MY4 A;  2GSN A;  5HRT A;  1AJA A;  5TJ3 A;  1N2L A;  3MK2 A;  3WBH A;  2W5X A;  3KD8 A;  3UN2 A;  3T02 A;  4YR1 A;  5EGE A;  1ZED A;  3DYC A;  3OT9 A;  2D1G A;  3LXQ A;  4NWJ A;  5DLV A;  1ALJ A;  1AJB A;  4UPH A;  1P49 A;  5L0E A;  1EW9 A;  1E33 P;  2G9Y A;  3MK1 A;  1ALI A;  4LRF A;  3M8Y A;  1EQJ A;  3BDG A;  4UOR A;  3NKN A;  3NKP A;  4KAV A;  4CYR A;  5LRN A;  3A52 A;  1ED9 A;  4LQY A;  3T00 A;  4LR8 A;  3WAY A;  5GRR A;  1EI6 A;  1O98 A;  1E1Z P;  5L0B A;  1EJJ A;  1HQA A;  3IGZ B;  3TWZ A;  1KH4 A;  2RH6 A;  2W8D A;  5INH A;  3UO0 A;  1Y6V A;  3B5Q A;  2ZKT A;  5IJQ A;  3WAV A;  1ELY A;  4CXK A;  1HJK A;  3SZZ A;  2GSU A;  1KH9 A;  1KHL A;  3NKO A;  4NWX A;  4GTZ A;  4KM4 A;  2IUC B;  1SHQ A;  4UPL A; 
#chains in the Genus database with same CATH homology
 1EW2 A;  4ZGA A;  2W5R A;  4KJG A;  2W5T A;  5DLW A;  5DLT A;  2W5Q A;  2W8S A;  3TX0 A;  1EW8 A;  3M8W A;  4GTX A;  3Q3Q A;  1ZEB A;  4CXU A;  3T01 A;  3M7V A;  1B8J A;  3ED4 A;  4LRB A;  1E3C P;  1URA A;  5K4P A;  3TG0 A;  4MIV A;  2VQR A;  3UN3 A;  5IJS A;  3E2D A;  2QZU A;  4KJD A;  4LRC A;  3DPC A;  4UOO A;  3SZY A;  3WAW A;  3UN5 A;  1ELZ A;  3BDF A;  4LRD A;  3UNY A;  1ELX A;  4GTY A;  1AJC A;  4KAY A;  2GA3 A;  3NKM A;  3WAX A;  5L0K A;  3M8Z A;  1KH7 A;  1URB A;  3NKQ A;  4ZG7 A;  4LR2 A;  1O99 A;  4LRE A;  2X98 A;  5LRM A;  1ALH A;  1N2K A;  1Y7A A;  3NVL A;  1KHN A;  4N7T A;  5LQQ A;  5KXA A;  4CXS A;  4B56 A;  2W5V A;  3MK0 A;  4UOP A;  5GOV A;  1ANI A;  2IUC A;  4LRA A;  3IGY B;  1KH5 A;  4CYS A;  2ANH A;  2XR9 A;  3BDG B;  3IDD A;  4GTW A;  4FDI A;  1AUK A;  4LR7 A;  1K7H A;  1ALK A;  5LIA A;  1E2S P;  4UPI A;  4UPK A;  1FSU A;  4FDJ A;  4QAX A;  2IFY A;  3NKR A;  1ANJ A;  1SHN A;  2GLQ A;  4LR9 A;  3BDH A;  5C66 A;  3CMR A;  4ZG9 A;  2W5S A;  1AJD A;  1KHJ A;  2W5W A;  2XRG A;  5EGH A;  1HDH A;  4TN0 A;  1KHK A;  4MHX A;  2GSO A;  4ZG6 A;  5AJ9 A;  1ZEF A;  1ED8 A;  4MY4 A;  2GSN A;  5HRT A;  1AJA A;  5TJ3 A;  1N2L A;  3MK2 A;  3WBH A;  2W5X A;  3KD8 A;  3UN2 A;  3T02 A;  4YR1 A;  5EGE A;  1ZED A;  3DYC A;  3OT9 A;  2D1G A;  3LXQ A;  4NWJ A;  5DLV A;  1ALJ A;  1AJB A;  4UPH A;  1P49 A;  5L0E A;  1EW9 A;  1E33 P;  2G9Y A;  3MK1 A;  1ALI A;  4LRF A;  3M8Y A;  1EQJ A;  3BDG A;  4UOR A;  3NKN A;  3NKP A;  4KAV A;  4CYR A;  5LRN A;  3A52 A;  1ED9 A;  4LQY A;  3T00 A;  4LR8 A;  3WAY A;  5GRR A;  1EI6 A;  1O98 A;  1E1Z P;  5L0B A;  1EJJ A;  1HQA A;  3IGZ B;  3TWZ A;  1KH4 A;  2RH6 A;  2W8D A;  5INH A;  3UO0 A;  1Y6V A;  3B5Q A;  2ZKT A;  5IJQ A;  3WAV A;  1ELY A;  4CXK A;  1HJK A;  3SZZ A;  2GSU A;  1KH9 A;  1KHL A;  3NKO A;  4NWX A;  4GTZ A;  4KM4 A;  2IUC B;  1SHQ A;  4UPL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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