3C10A

Crystal structure of catalytic domain of human histone deacetylase hdac7 in complex with trichostatin a (tsa)
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
386
structure length
383
Chain Sequence
TLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone deacetylase 7a
publication title Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 135
structure length 383
sequence length 386
chains with identical sequence B, C
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3c10A00
1ZZ3A 5EEFA 3RQDA 5DC8A 3MZ4A 5EFKB 5EFJD 4RN0A 3MZ7A 2VQWG 5EF8A 3SFFA 5FCWA 4QA0A 3F0RA 4ZUQA 5D1BA 1C3PA 5G0JA 4CBTA 4ZUOA 5G10A 2V5XA 2GH6A 4ZURA 5JI5A 2VCGA 4A69A 1VKGA 2VQJA 4RN2A 3EZTA 5IX0A 4BZ7A 5G0HA 4BKXB 3F07A 4BZ5A 5D1CA 2VQMA 5EFBD 2VQQA 4BZ6A 5EFGA 5DC7A 3Q9CA 1W22A 5EEMA 3ZNSA 1ZZ1A 4LXZA 3C10A 4QA6A 5G1CA 1T64A 5EENA 3SFHA 4QA7A 5EFHA 2VQVA 5THTA 3EWFA 1T67A 4QA4A 5BWZA 5LI3A 4CBYA 1C3RA 5G17A 5EEKA 5EF7A 4QA1A 4ZUMA 3C0ZA 5G1BA 5ICNB 4RN1A 5G0GA 1ZZ0A 3Q9EA 5THUA 5G1AA 4QA5A 2VQOA 1T69A 5G3WA 5A2SA 4QA2A 5EEIA 3Q9BA 3MZ3A 5DC5A 5EFNA 3EW8A 3F06A 5THSA 3MENA 3Q9FA 3EZPA 4ZUNA 5G13A 5THVA 4CQFA 5G11A 5G0XA 4BZ9A 5FUEA 4LY1A 5G0IA 5D1DA 5G0YA 5IWGA 4ZUPA 2V5WA 3MAXA 4QA3A 3ZNRA 5DC6A 1C3SA 3MZ6A 4BZ8A 5G12A 3C0YA
chains in the Genus database with same CATH superfamily
3MFWA 1ZZ3A 5EEFA 1P8OA 2PHAA 4Q3VA 3M1RA 3RQDA 5DC8A 2RLAA 3MZ4A 5EFKB 5EFJD 4CEVA 3SL0A 4DZ4A 3E8ZA 4IE3A 4RN0A 3MZ7A 2VQWG 5EF8A 4ITYA 4IU4A 3MMRA 3SFFA 1ZPEA 5FCWA 4RHIA 4QA0A 3F0RA 2PHOA 3NIQA 4RHMA 4ZUQA 4G3HA 1HQHA 3LP7A 5D1BA 1C3PA 5G0JA 1T4PA 4HWWA 4CBTA 4ZUOA 2AEBA 1R1OA 5G10A 3SJTA 2V5XA 2GH6A 4Q3SA 4Q3RC 4RHKA 4ZURA 1T4TA 3GMZA 5JI5A 3THHA 2VCGA 1TBLA 4A69A 1WVBA 1VKGA 2VQJA 4RN2A 5HJ9A 3EZTA 3E9BA 5IX0A 4BZ7A 5G0HA 4BKXB 5RLAA 3F07A 1D3VA 3TH7A 4BZ5A 1T5GA 4FCKA 5D1CA 2VQMA 5EFBD 2VQQA 4BZ6A 1GQ7A 1CEVA 1XFKA 4RHJA 2EF4A 3DJ8A 4MYLA 4Q3RA 3MFVA 5EFGA 4RLAA 5DC7A 3Q9CA 3F80A 1W22A 5EEMA 4IXUA 3ZNSA 1ZZ1A 3LHLA 1P8NA 4LXZA 3C10A 4QA6A 5G1CA 3RLAA 3TF3A 1T64A 4GWCA 5EENA 3SFHA 3GN0A 4GWDA 4QA7A 5EFHA 4GSZA 2A0MA 2VQVA 4MYFA 5THTA 3EWFA 4HXQA 1P8PA 1T67A 4QA4A 1TA1A 4RHLA 2EF5A 5CEVA 5BWZA 5LI3A 4CBYA 3SL1A 1C3RA 4IU0A 1GQ6A 4GSVA 4IU5A 4Q3UA 5G17A 1HQGA 5EEKA 4IE2A 5EF7A 4QA1A 4ZUMA 2PLLA 2ZAVA 4Q3PA 3C0ZA 3PZLA 5G1BA 5ICNB 3THEA 4RN1A 5G0GA 4HZEA 4FCIA 1WVAA 1WOGA 1ZZ0A 3E8QA 1PQ3A 3Q9EA 5THUA 5G1AA 3MJLA 4Q42A 1T4RA 1TBJA 4QA5A 2VQOA 1T5FA 1T4SA 3LP4A 4Q40A 1T69A 1P8MA 5G3WA 5A2SA 4Q41A 3MZ3A 4QA2A 3Q9BA 1HQXA 5EEIA 5DC5A 5EFNA 4Q3QA 3EW8A 4Q3TA 3F06A 1P8RA 4I06A 5THSA 3MENA 2EIVA 4RHQA 3Q9FA 4IXVA 4MYNA 3KV2A 5HJAA 3EZPA 4ZUNA 4IU1A 1P8SA 1ZPGA 1WOIA 4IE1A 3NIPA 5G13A 5THVA 4CQFA 5G11A 2CEVA 5G0XA 3E6KA 4BZ9A 1P8QA 5FUEA 4LY1A 3CEVA 4MYKA 5G0IA 5D1DA 5G0YA 5IWGA 4ZUPA 2V5WA 3MAXA 4QA3A 3SKKA 1WOHA 5DC6A 4GSMA 4MXRA 3ZNRA 1HQ5A 1C3SA 1HQFA 1TBHA 3MZ6A 4BZ8A 1RLAA 5G12A 3E6VA 3NIOA 3THJA 3C0YA
chains in the Genus database with same CATH topology
1ZZ3A 5EEFA 3RQDA 5DC8A 3MZ4A 5EFKB 5EFJD 4RN0A 3MZ7A 2VQWG 5EF8A 3SFFA 5FCWA 4QA0A 3F0RA 4ZUQA 5D1BA 1C3PA 5G0JA 4CBTA 4ZUOA 5G10A 2V5XA 2GH6A 4ZURA 5JI5A 2VCGA 4A69A 1VKGA 2VQJA 4RN2A 3EZTA 5IX0A 4BZ7A 5G0HA 4BKXB 3F07A 4BZ5A 5D1CA 2VQMA 5EFBD 2VQQA 4BZ6A 5EFGA 5DC7A 3Q9CA 1W22A 5EEMA 3ZNSA 1ZZ1A 4LXZA 3C10A 4QA6A 5G1CA 1T64A 5EENA 3SFHA 4QA7A 5EFHA 2VQVA 5THTA 3EWFA 1T67A 4QA4A 5BWZA 5LI3A 4CBYA 1C3RA 5G17A 5EEKA 5EF7A 4QA1A 4ZUMA 3C0ZA 5G1BA 5ICNB 4RN1A 5G0GA 1ZZ0A 3Q9EA 5THUA 5G1AA 4QA5A 2VQOA 1T69A 5G3WA 5A2SA 4QA2A 5EEIA 3Q9BA 3MZ3A 5DC5A 5EFNA 3EW8A 3F06A 5THSA 3MENA 3Q9FA 3EZPA 4ZUNA 5G13A 5THVA 4CQFA 5G11A 5G0XA 4BZ9A 5FUEA 4LY1A 5G0IA 5D1DA 5G0YA 5IWGA 4ZUPA 2V5WA 3MAXA 4QA3A 3ZNRA 5DC6A 1C3SA 3MZ6A 4BZ8A 5G12A 3C0YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZZ3 A;  5EEF A;  3RQD A;  5DC8 A;  3MZ4 A;  5EFK B;  5EFJ D;  4RN0 A;  3MZ7 A;  2VQW G;  5EF8 A;  3SFF A;  5FCW A;  4QA0 A;  3F0R A;  4ZUQ A;  5D1B A;  1C3P A;  5G0J A;  4CBT A;  4ZUO A;  5G10 A;  2V5X A;  2GH6 A;  4ZUR A;  5JI5 A;  2VCG A;  4A69 A;  1VKG A;  2VQJ A;  4RN2 A;  3EZT A;  5IX0 A;  4BZ7 A;  5G0H A;  4BKX B;  3F07 A;  4BZ5 A;  5D1C A;  2VQM A;  5EFB D;  2VQQ A;  4BZ6 A;  5EFG A;  5DC7 A;  3Q9C A;  1W22 A;  5EEM A;  3ZNS A;  1ZZ1 A;  4LXZ A;  3C10 A;  4QA6 A;  5G1C A;  1T64 A;  5EEN A;  3SFH A;  4QA7 A;  5EFH A;  2VQV A;  5THT A;  3EWF A;  1T67 A;  4QA4 A;  5BWZ A;  5LI3 A;  4CBY A;  1C3R A;  5G17 A;  5EEK A;  5EF7 A;  4QA1 A;  4ZUM A;  3C0Z A;  5G1B A;  5ICN B;  4RN1 A;  5G0G A;  1ZZ0 A;  3Q9E A;  5THU A;  5G1A A;  4QA5 A;  2VQO A;  1T69 A;  5G3W A;  5A2S A;  4QA2 A;  5EEI A;  3Q9B A;  3MZ3 A;  5DC5 A;  5EFN A;  3EW8 A;  3F06 A;  5THS A;  3MEN A;  3Q9F A;  3EZP A;  4ZUN A;  5G13 A;  5THV A;  4CQF A;  5G11 A;  5G0X A;  4BZ9 A;  5FUE A;  4LY1 A;  5G0I A;  5D1D A;  5G0Y A;  5IWG A;  4ZUP A;  2V5W A;  3MAX A;  4QA3 A;  3ZNR A;  5DC6 A;  1C3S A;  3MZ6 A;  4BZ8 A;  5G12 A;  3C0Y A; 
#chains in the Genus database with same CATH topology
 3MFW A;  1ZZ3 A;  5EEF A;  1P8O A;  2PHA A;  4Q3V A;  3M1R A;  3RQD A;  5DC8 A;  2RLA A;  3MZ4 A;  5EFK B;  5EFJ D;  4CEV A;  3SL0 A;  4DZ4 A;  3E8Z A;  4IE3 A;  4RN0 A;  3MZ7 A;  2VQW G;  5EF8 A;  4ITY A;  4IU4 A;  3MMR A;  3SFF A;  1ZPE A;  5FCW A;  4RHI A;  4QA0 A;  3F0R A;  2PHO A;  3NIQ A;  4RHM A;  4ZUQ A;  4G3H A;  1HQH A;  3LP7 A;  5D1B A;  1C3P A;  5G0J A;  1T4P A;  4HWW A;  4CBT A;  4ZUO A;  2AEB A;  1R1O A;  5G10 A;  3SJT A;  2V5X A;  2GH6 A;  4Q3S A;  4Q3R C;  4RHK A;  4ZUR A;  1T4T A;  3GMZ A;  5JI5 A;  3THH A;  2VCG A;  1TBL A;  4A69 A;  1WVB A;  1VKG A;  2VQJ A;  4RN2 A;  5HJ9 A;  3EZT A;  3E9B A;  5IX0 A;  4BZ7 A;  5G0H A;  4BKX B;  5RLA A;  3F07 A;  1D3V A;  3TH7 A;  4BZ5 A;  1T5G A;  4FCK A;  5D1C A;  2VQM A;  5EFB D;  2VQQ A;  4BZ6 A;  1GQ7 A;  1CEV A;  1XFK A;  4RHJ A;  2EF4 A;  3DJ8 A;  4MYL A;  4Q3R A;  3MFV A;  5EFG A;  4RLA A;  5DC7 A;  3Q9C A;  3F80 A;  1W22 A;  5EEM A;  4IXU A;  3ZNS A;  1ZZ1 A;  3LHL A;  1P8N A;  4LXZ A;  3C10 A;  4QA6 A;  5G1C A;  3RLA A;  3TF3 A;  1T64 A;  4GWC A;  5EEN A;  3SFH A;  3GN0 A;  4GWD A;  4QA7 A;  5EFH A;  4GSZ A;  2A0M A;  2VQV A;  4MYF A;  5THT A;  3EWF A;  4HXQ A;  1P8P A;  1T67 A;  4QA4 A;  1TA1 A;  4RHL A;  2EF5 A;  5CEV A;  5BWZ A;  5LI3 A;  4CBY A;  3SL1 A;  1C3R A;  4IU0 A;  1GQ6 A;  4GSV A;  4IU5 A;  4Q3U A;  5G17 A;  1HQG A;  5EEK A;  4IE2 A;  5EF7 A;  4QA1 A;  4ZUM A;  2PLL A;  2ZAV A;  4Q3P A;  3C0Z A;  3PZL A;  5G1B A;  5ICN B;  3THE A;  4RN1 A;  5G0G A;  4HZE A;  4FCI A;  1WVA A;  1WOG A;  1ZZ0 A;  3E8Q A;  1PQ3 A;  3Q9E A;  5THU A;  5G1A A;  3MJL A;  4Q42 A;  1T4R A;  1TBJ A;  4QA5 A;  2VQO A;  1T5F A;  1T4S A;  3LP4 A;  4Q40 A;  1T69 A;  1P8M A;  5G3W A;  5A2S A;  4Q41 A;  3MZ3 A;  4QA2 A;  3Q9B A;  1HQX A;  5EEI A;  5DC5 A;  5EFN A;  4Q3Q A;  3EW8 A;  4Q3T A;  3F06 A;  1P8R A;  4I06 A;  5THS A;  3MEN A;  2EIV A;  4RHQ A;  3Q9F A;  4IXV A;  4MYN A;  3KV2 A;  5HJA A;  3EZP A;  4ZUN A;  4IU1 A;  1P8S A;  1ZPG A;  1WOI A;  4IE1 A;  3NIP A;  5G13 A;  5THV A;  4CQF A;  5G11 A;  2CEV A;  5G0X A;  3E6K A;  4BZ9 A;  1P8Q A;  5FUE A;  4LY1 A;  3CEV A;  4MYK A;  5G0I A;  5D1D A;  5G0Y A;  5IWG A;  4ZUP A;  2V5W A;  3MAX A;  4QA3 A;  3SKK A;  1WOH A;  5DC6 A;  4GSM A;  4MXR A;  3ZNR A;  1HQ5 A;  1C3S A;  1HQF A;  1TBH A;  3MZ6 A;  4BZ8 A;  1RLA A;  5G12 A;  3E6V A;  3NIO A;  3THJ A;  3C0Y A; 
#chains in the Genus database with same CATH homology
 1ZZ3 A;  5EEF A;  3RQD A;  5DC8 A;  3MZ4 A;  5EFK B;  5EFJ D;  4RN0 A;  3MZ7 A;  2VQW G;  5EF8 A;  3SFF A;  5FCW A;  4QA0 A;  3F0R A;  4ZUQ A;  5D1B A;  1C3P A;  5G0J A;  4CBT A;  4ZUO A;  5G10 A;  2V5X A;  2GH6 A;  4ZUR A;  5JI5 A;  2VCG A;  4A69 A;  1VKG A;  2VQJ A;  4RN2 A;  3EZT A;  5IX0 A;  4BZ7 A;  5G0H A;  4BKX B;  3F07 A;  4BZ5 A;  5D1C A;  2VQM A;  5EFB D;  2VQQ A;  4BZ6 A;  5EFG A;  5DC7 A;  3Q9C A;  1W22 A;  5EEM A;  3ZNS A;  1ZZ1 A;  4LXZ A;  3C10 A;  4QA6 A;  5G1C A;  1T64 A;  5EEN A;  3SFH A;  4QA7 A;  5EFH A;  2VQV A;  5THT A;  3EWF A;  1T67 A;  4QA4 A;  5BWZ A;  5LI3 A;  4CBY A;  1C3R A;  5G17 A;  5EEK A;  5EF7 A;  4QA1 A;  4ZUM A;  3C0Z A;  5G1B A;  5ICN B;  4RN1 A;  5G0G A;  1ZZ0 A;  3Q9E A;  5THU A;  5G1A A;  4QA5 A;  2VQO A;  1T69 A;  5G3W A;  5A2S A;  4QA2 A;  5EEI A;  3Q9B A;  3MZ3 A;  5DC5 A;  5EFN A;  3EW8 A;  3F06 A;  5THS A;  3MEN A;  3Q9F A;  3EZP A;  4ZUN A;  5G13 A;  5THV A;  4CQF A;  5G11 A;  5G0X A;  4BZ9 A;  5FUE A;  4LY1 A;  5G0I A;  5D1D A;  5G0Y A;  5IWG A;  4ZUP A;  2V5W A;  3MAX A;  4QA3 A;  3ZNR A;  5DC6 A;  1C3S A;  3MZ6 A;  4BZ8 A;  5G12 A;  3C0Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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