3C10A

Crystal structure of catalytic domain of human histone deacetylase hdac7 in complex with trichostatin a (tsa)
Total Genus 135
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
135
sequence length
386
structure length
383
Chain Sequence
TLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Histone deacetylase 7a
publication title Human HDAC7 harbors a class IIa histone deacetylase-specific zinc binding motif and cryptic deacetylase activity.
pubmed doi rcsb
source organism Homo sapiens
total genus 135
structure length 383
sequence length 386
chains with identical sequence B, C
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-01-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3c10A00
2VCGA 3Q9CA 4ZUNA 1C3PA 5THTA 4ZUQA 5EF8A 5G10A 5DC7A 4RN0A 5THVA 5EFJD 4QA5A 5DC8A 4BZ7A 5EF7A 5EENA 5G0GA 3SFFA 3EZPA 3MENA 3Q9FA 5EFGA 5EEFA 5G13A 4BKXB 5EFNA 4BZ5A 4LXZA 5G0IA 5DC6A 5G1BA 4QA3A 5G12A 1C3RA 5D1DA 3F0RA 1ZZ0A 2V5XA 2VQWG 3Q9EA 5DC5A 5JI5A 5G1CA 3EWFA 3MAXA 4LY1A 5BWZA 4ZUPA 5LI3A 5G1AA 5G0JA 4ZUOA 5IX0A 5FUEA 3RQDA 3C0YA 2V5WA 3MZ3A 4BZ8A 5EEMA 5G0YA 5FCWA 1ZZ3A 1ZZ1A 4ZURA 3EZTA 4BZ6A 2VQQA 1VKGA 5EFKB 4QA4A 3C0ZA 3MZ4A 1W22A 4ZUMA 4RN1A 5G0XA 4CBYA 2VQOA 5D1CA 2VQJA 5G3WA 3EW8A 4A69A 1T69A 1C3SA 3ZNRA 5G11A 5G17A 3F06A 3F07A 3C10A 4CBTA 1T64A 4QA0A 4QA1A 4QA7A 5EFBD 4BZ9A 4CQFA 2VQMA 5IWGA 1T67A 2GH6A 2VQVA 5D1BA 3ZNSA 5THSA 4QA6A 3SFHA 3MZ7A 5G0HA 5EFHA 3Q9BA 4QA2A 5EEIA 4RN2A 5A2SA 5EEKA 5THUA 5ICNB 3MZ6A
chains in the Genus database with same CATH superfamily
4MYLA 2VCGA 1GQ6A 3Q9CA 1R1OA 4ZUNA 1C3PA 5THTA 4Q3RA 4ZUQA 2A0MA 5EF8A 5G10A 3E8ZA 5DC7A 4RN0A 5THVA 4FCIA 5EFJD 2ZAVA 4QA5A 5DC8A 4BZ7A 4GWCA 1HQXA 4RHIA 5EF7A 5EENA 1TBHA 1ZPGA 4Q3QA 3EZPA 3MENA 3PZLA 3KV2A 1D3VA 3Q9FA 4Q3RC 4Q3TA 4Q42A 5EFGA 5EEFA 1P8NA 5G13A 4BKXB 4IE3A 5EFNA 4IE1A 4BZ5A 4LXZA 4IXUA 5G0IA 5DC6A 5G1BA 3SL1A 4QA3A 5G12A 1ZPEA 4GWDA 1C3RA 5D1DA 5ICNB 3SJTA 4GSZA 3DJ8A 3SKKA 1T4SA 3F0RA 5HJAA 1ZZ0A 2V5XA 2VQWG 3Q9EA 4Q3VA 4Q40A 4Q3PA 5DC5A 2CEVA 4RLAA 1TBJA 5JI5A 1WVAA 5G1CA 3EWFA 1T4TA 1WOIA 3MAXA 4LY1A 5BWZA 4ZUPA 3TH7A 1HQHA 2PLLA 3E6KA 5LI3A 5G1AA 5G0JA 3M1RA 3MMRA 4ZUOA 5G0GA 5IX0A 1GQ7A 5FUEA 4MYFA 4MYNA 3THJA 3RLAA 4IU1A 3RQDA 3MFWA 3SL0A 3C0YA 2V5WA 3MZ3A 4BZ8A 5EEMA 4RHMA 5G0YA 3LHLA 1P8SA 5FCWA 4Q41A 1ZZ3A 1HQ5A 3E8QA 3LP4A 3E6VA 1RLAA 1ZZ1A 4RHQA 1TBLA 2EF5A 4ZURA 4RHLA 3THEA 3EZTA 4BZ6A 1WVBA 4IXVA 2VQQA 5RLAA 1T5GA 1T4PA 1VKGA 1TA1A 5EFKB 4QA4A 3C0ZA 4MYKA 3MZ4A 1W22A 4IU0A 1PQ3A 4RN1A 4ZUMA 5G0XA 4CBYA 2VQOA 4DZ4A 5D1CA 2AEBA 1CEVA 2RLAA 3CEVA 3GMZA 2VQJA 4RHKA 5G3WA 3EW8A 1HQGA 5HJ9A 4GSMA 4A69A 1C3SA 1T69A 3NIOA 4HWWA 3MFVA 4RHJA 3MJLA 3ZNRA 4ITYA 5CEVA 5G11A 3GN0A 3SFFA 5G17A 3THHA 3LP7A 1WOHA 4MXRA 3F06A 4FCKA 4Q3UA 3F07A 3C10A 3TF3A 2EIVA 2PHAA 1WOGA 1XFKA 4HZEA 4CBTA 1HQFA 1T64A 1P8PA 4QA0A 4QA1A 4QA7A 1P8OA 2PHOA 4GSVA 5EFBD 4HXQA 4BZ9A 4CQFA 2VQMA 5IWGA 1T67A 3NIQA 2GH6A 2VQVA 5D1BA 4IE2A 3ZNSA 5THSA 4QA6A 3SFHA 3E9BA 3MZ7A 1T4RA 5G0HA 4G3HA 4IU4A 3NIPA 2EF4A 3F80A 3Q9BA 4QA2A 5EFHA 1T5FA 4CEVA 5EEIA 4I06A 4RN2A 1P8MA 1P8RA 4Q3SA 4IU5A 5A2SA 5EEKA 1P8QA 5THUA 3MZ6A
chains in the Genus database with same CATH topology
2VCGA 3Q9CA 4ZUNA 1C3PA 5THTA 4ZUQA 5EF8A 5G10A 5DC7A 4RN0A 5THVA 5EFJD 4QA5A 5DC8A 4BZ7A 5EF7A 5EENA 5G0GA 3SFFA 3EZPA 3MENA 3Q9FA 5EFGA 5EEFA 5G13A 4BKXB 5EFNA 4BZ5A 4LXZA 5G0IA 5DC6A 5G1BA 4QA3A 5G12A 1C3RA 5D1DA 3F0RA 1ZZ0A 2V5XA 2VQWG 3Q9EA 5DC5A 5JI5A 5G1CA 3EWFA 3MAXA 4LY1A 5BWZA 4ZUPA 5LI3A 5G1AA 5G0JA 4ZUOA 5IX0A 5FUEA 3RQDA 3C0YA 2V5WA 3MZ3A 4BZ8A 5EEMA 5G0YA 5FCWA 1ZZ3A 1ZZ1A 4ZURA 3EZTA 4BZ6A 2VQQA 1VKGA 5EFKB 4QA4A 3C0ZA 3MZ4A 1W22A 4ZUMA 4RN1A 5G0XA 4CBYA 2VQOA 5D1CA 2VQJA 5G3WA 3EW8A 4A69A 1T69A 1C3SA 3ZNRA 5G11A 5G17A 3F06A 3F07A 3C10A 4CBTA 1T64A 4QA0A 4QA1A 4QA7A 5EFBD 4BZ9A 4CQFA 2VQMA 5IWGA 1T67A 2GH6A 2VQVA 5D1BA 3ZNSA 5THSA 4QA6A 3SFHA 3MZ7A 5G0HA 5EFHA 3Q9BA 4QA2A 5EEIA 4RN2A 5A2SA 5EEKA 5THUA 5ICNB 3MZ6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VCG A;  3Q9C A;  4ZUN A;  1C3P A;  5THT A;  4ZUQ A;  5EF8 A;  5G10 A;  5DC7 A;  4RN0 A;  5THV A;  5EFJ D;  4QA5 A;  5DC8 A;  4BZ7 A;  5EF7 A;  5EEN A;  5G0G A;  3SFF A;  3EZP A;  3MEN A;  3Q9F A;  5EFG A;  5EEF A;  5G13 A;  4BKX B;  5EFN A;  4BZ5 A;  4LXZ A;  5G0I A;  5DC6 A;  5G1B A;  4QA3 A;  5G12 A;  1C3R A;  5D1D A;  3F0R A;  1ZZ0 A;  2V5X A;  2VQW G;  3Q9E A;  5DC5 A;  5JI5 A;  5G1C A;  3EWF A;  3MAX A;  4LY1 A;  5BWZ A;  4ZUP A;  5LI3 A;  5G1A A;  5G0J A;  4ZUO A;  5IX0 A;  5FUE A;  3RQD A;  3C0Y A;  2V5W A;  3MZ3 A;  4BZ8 A;  5EEM A;  5G0Y A;  5FCW A;  1ZZ3 A;  1ZZ1 A;  4ZUR A;  3EZT A;  4BZ6 A;  2VQQ A;  1VKG A;  5EFK B;  4QA4 A;  3C0Z A;  3MZ4 A;  1W22 A;  4ZUM A;  4RN1 A;  5G0X A;  4CBY A;  2VQO A;  5D1C A;  2VQJ A;  5G3W A;  3EW8 A;  4A69 A;  1T69 A;  1C3S A;  3ZNR A;  5G11 A;  5G17 A;  3F06 A;  3F07 A;  3C10 A;  4CBT A;  1T64 A;  4QA0 A;  4QA1 A;  4QA7 A;  5EFB D;  4BZ9 A;  4CQF A;  2VQM A;  5IWG A;  1T67 A;  2GH6 A;  2VQV A;  5D1B A;  3ZNS A;  5THS A;  4QA6 A;  3SFH A;  3MZ7 A;  5G0H A;  5EFH A;  3Q9B A;  4QA2 A;  5EEI A;  4RN2 A;  5A2S A;  5EEK A;  5THU A;  5ICN B;  3MZ6 A; 
#chains in the Genus database with same CATH topology
 4MYL A;  2VCG A;  1GQ6 A;  3Q9C A;  1R1O A;  4ZUN A;  1C3P A;  5THT A;  4Q3R A;  4ZUQ A;  2A0M A;  5EF8 A;  5G10 A;  3E8Z A;  5DC7 A;  4RN0 A;  5THV A;  4FCI A;  5EFJ D;  2ZAV A;  4QA5 A;  5DC8 A;  4BZ7 A;  4GWC A;  1HQX A;  4RHI A;  5EF7 A;  5EEN A;  1TBH A;  1ZPG A;  4Q3Q A;  3EZP A;  3MEN A;  3PZL A;  3KV2 A;  1D3V A;  3Q9F A;  4Q3R C;  4Q3T A;  4Q42 A;  5EFG A;  5EEF A;  1P8N A;  5G13 A;  4BKX B;  4IE3 A;  5EFN A;  4IE1 A;  4BZ5 A;  4LXZ A;  4IXU A;  5G0I A;  5DC6 A;  5G1B A;  3SL1 A;  4QA3 A;  5G12 A;  1ZPE A;  4GWD A;  1C3R A;  5D1D A;  5ICN B;  3SJT A;  4GSZ A;  3DJ8 A;  3SKK A;  1T4S A;  3F0R A;  5HJA A;  1ZZ0 A;  2V5X A;  2VQW G;  3Q9E A;  4Q3V A;  4Q40 A;  4Q3P A;  5DC5 A;  2CEV A;  4RLA A;  1TBJ A;  5JI5 A;  1WVA A;  5G1C A;  3EWF A;  1T4T A;  1WOI A;  3MAX A;  4LY1 A;  5BWZ A;  4ZUP A;  3TH7 A;  1HQH A;  2PLL A;  3E6K A;  5LI3 A;  5G1A A;  5G0J A;  3M1R A;  3MMR A;  4ZUO A;  5G0G A;  5IX0 A;  1GQ7 A;  5FUE A;  4MYF A;  4MYN A;  3THJ A;  3RLA A;  4IU1 A;  3RQD A;  3MFW A;  3SL0 A;  3C0Y A;  2V5W A;  3MZ3 A;  4BZ8 A;  5EEM A;  4RHM A;  5G0Y A;  3LHL A;  1P8S A;  5FCW A;  4Q41 A;  1ZZ3 A;  1HQ5 A;  3E8Q A;  3LP4 A;  3E6V A;  1RLA A;  1ZZ1 A;  4RHQ A;  1TBL A;  2EF5 A;  4ZUR A;  4RHL A;  3THE A;  3EZT A;  4BZ6 A;  1WVB A;  4IXV A;  2VQQ A;  5RLA A;  1T5G A;  1T4P A;  1VKG A;  1TA1 A;  5EFK B;  4QA4 A;  3C0Z A;  4MYK A;  3MZ4 A;  1W22 A;  4IU0 A;  1PQ3 A;  4RN1 A;  4ZUM A;  5G0X A;  4CBY A;  2VQO A;  4DZ4 A;  5D1C A;  2AEB A;  1CEV A;  2RLA A;  3CEV A;  3GMZ A;  2VQJ A;  4RHK A;  5G3W A;  3EW8 A;  1HQG A;  5HJ9 A;  4GSM A;  4A69 A;  1C3S A;  1T69 A;  3NIO A;  4HWW A;  3MFV A;  4RHJ A;  3MJL A;  3ZNR A;  4ITY A;  5CEV A;  5G11 A;  3GN0 A;  3SFF A;  5G17 A;  3THH A;  3LP7 A;  1WOH A;  4MXR A;  3F06 A;  4FCK A;  4Q3U A;  3F07 A;  3C10 A;  3TF3 A;  2EIV A;  2PHA A;  1WOG A;  1XFK A;  4HZE A;  4CBT A;  1HQF A;  1T64 A;  1P8P A;  4QA0 A;  4QA1 A;  4QA7 A;  1P8O A;  2PHO A;  4GSV A;  5EFB D;  4HXQ A;  4BZ9 A;  4CQF A;  2VQM A;  5IWG A;  1T67 A;  3NIQ A;  2GH6 A;  2VQV A;  5D1B A;  4IE2 A;  3ZNS A;  5THS A;  4QA6 A;  3SFH A;  3E9B A;  3MZ7 A;  1T4R A;  5G0H A;  4G3H A;  4IU4 A;  3NIP A;  2EF4 A;  3F80 A;  3Q9B A;  4QA2 A;  5EFH A;  1T5F A;  4CEV A;  5EEI A;  4I06 A;  4RN2 A;  1P8M A;  1P8R A;  4Q3S A;  4IU5 A;  5A2S A;  5EEK A;  1P8Q A;  5THU A;  3MZ6 A; 
#chains in the Genus database with same CATH homology
 2VCG A;  3Q9C A;  4ZUN A;  1C3P A;  5THT A;  4ZUQ A;  5EF8 A;  5G10 A;  5DC7 A;  4RN0 A;  5THV A;  5EFJ D;  4QA5 A;  5DC8 A;  4BZ7 A;  5EF7 A;  5EEN A;  5G0G A;  3SFF A;  3EZP A;  3MEN A;  3Q9F A;  5EFG A;  5EEF A;  5G13 A;  4BKX B;  5EFN A;  4BZ5 A;  4LXZ A;  5G0I A;  5DC6 A;  5G1B A;  4QA3 A;  5G12 A;  1C3R A;  5D1D A;  3F0R A;  1ZZ0 A;  2V5X A;  2VQW G;  3Q9E A;  5DC5 A;  5JI5 A;  5G1C A;  3EWF A;  3MAX A;  4LY1 A;  5BWZ A;  4ZUP A;  5LI3 A;  5G1A A;  5G0J A;  4ZUO A;  5IX0 A;  5FUE A;  3RQD A;  3C0Y A;  2V5W A;  3MZ3 A;  4BZ8 A;  5EEM A;  5G0Y A;  5FCW A;  1ZZ3 A;  1ZZ1 A;  4ZUR A;  3EZT A;  4BZ6 A;  2VQQ A;  1VKG A;  5EFK B;  4QA4 A;  3C0Z A;  3MZ4 A;  1W22 A;  4ZUM A;  4RN1 A;  5G0X A;  4CBY A;  2VQO A;  5D1C A;  2VQJ A;  5G3W A;  3EW8 A;  4A69 A;  1T69 A;  1C3S A;  3ZNR A;  5G11 A;  5G17 A;  3F06 A;  3F07 A;  3C10 A;  4CBT A;  1T64 A;  4QA0 A;  4QA1 A;  4QA7 A;  5EFB D;  4BZ9 A;  4CQF A;  2VQM A;  5IWG A;  1T67 A;  2GH6 A;  2VQV A;  5D1B A;  3ZNS A;  5THS A;  4QA6 A;  3SFH A;  3MZ7 A;  5G0H A;  5EFH A;  3Q9B A;  4QA2 A;  5EEI A;  4RN2 A;  5A2S A;  5EEK A;  5THU A;  5ICN B;  3MZ6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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