3C5LA

Polo-like kinase 1 polo box domain in complex with pphspt peptide
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
221
structure length
217
Chain Sequence
HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGRLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Serine/threonine-protein kinase PLK1
total genus 68
structure length 217
sequence length 221
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2008-01-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3c5lA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3c5lA01
4J7BB 4H5XA 4X9VA 5DNJA 3P35A 4RCPA 2N19A 4H71A 4HABA 3HIHA 4HY2A 3P2WA 4XB0A 4E9DA 3FVHA 1Q4OA 3P2ZA 3P37A 3P36A 3RQ7A 4E9CA 4E67A 3BZIA 2OGQA 4X9WA 4YYPA 4LKMA 4O9WA 5LHZA 3HIKA 4DFWA 4WHKA 3C5LA 4X9RA 4HCOA 3P34A 3Q1IA 4O56A 2OJXA 1Q4KA 4LKLA 1UMWA 4WHLA 4O6WA 5DMSA 5DMVC 4RS6A 4WHHA 5J19A
chains in the Genus database with same CATH superfamily
4H71A 5DAYA 3KDRA 3P2WA 3HMJG 3GYWA 4FDIA 2OGQA 4LKMA 4O9WA 3HIKA 4NK7A 5AJ9A 3LXQA 4X9RA 4HCOA 3P34A 3Q1IA 1UMWA 4O6WA 3FS3A 4CYSA 2QZUA 4RS6A 4FDJA 1F34B 3ED4A 4J7BB 4H5XA 4CYRA 3P35A 2N19A 1N2KA 1E33P 1E2TA 4HY2A 4CXUA 1Q4OA 1E3CP 3RQ7A 1AUKA 2IA9A 4DFWA 1N2LA 2E50A 2I9XA 4CXKA 4N7ZA 4WHLA 1A87A 2VKZG 5DNJA 1HDHA 3HIHA 4E9DA 3P2ZA 3P37A 2I9ZA 3BZIA 4NKBA 4YYPA 4WHKA 4N7VA 3C5LA 1E2SP 1F32A 2OJXA 5DMSA 5DMVC 4WHHA 4X9VA 1FSUA 4RCPA 4HABA 4N9JA 4XB0A 3FVHA 3LM3A 3P36A 4E9CA 4E67A 4X9WA 5LHZA 4G7NA 3HFDA 4O56A 2UV8G 1P49A 1Q4KA 1E1ZP 4LKLA 4CXSA 5J19A 3GYVA
chains in the Genus database with same CATH topology
4J7BB 4H5XA 4X9VA 5DNJA 3P35A 4RCPA 2N19A 4H71A 4HABA 3HIHA 4HY2A 3P2WA 4XB0A 4E9DA 3FVHA 1Q4OA 3P2ZA 3P37A 3P36A 3RQ7A 4E9CA 4E67A 3BZIA 2OGQA 4X9WA 4YYPA 4LKMA 4O9WA 5LHZA 3HIKA 4DFWA 4WHKA 3C5LA 4X9RA 4HCOA 3P34A 3Q1IA 4O56A 2OJXA 1Q4KA 4LKLA 1UMWA 4WHLA 4O6WA 5DMSA 5DMVC 4RS6A 4WHHA 5J19A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7B B;  4H5X A;  4X9V A;  5DNJ A;  3P35 A;  4RCP A;  2N19 A;  4H71 A;  4HAB A;  3HIH A;  4HY2 A;  3P2W A;  4XB0 A;  4E9D A;  3FVH A;  1Q4O A;  3P2Z A;  3P37 A;  3P36 A;  3RQ7 A;  4E9C A;  4E67 A;  3BZI A;  2OGQ A;  4X9W A;  4YYP A;  4LKM A;  4O9W A;  5LHZ A;  3HIK A;  4DFW A;  4WHK A;  3C5L A;  4X9R A;  4HCO A;  3P34 A;  3Q1I A;  4O56 A;  2OJX A;  1Q4K A;  4LKL A;  1UMW A;  4WHL A;  4O6W A;  5DMS A;  5DMV C;  4RS6 A;  4WHH A;  5J19 A; 
#chains in the Genus database with same CATH topology
 4H71 A;  5DAY A;  3KDR A;  3P2W A;  3HMJ G;  3GYW A;  4FDI A;  2OGQ A;  4LKM A;  4O9W A;  3HIK A;  4NK7 A;  5AJ9 A;  3LXQ A;  4X9R A;  4HCO A;  3P34 A;  3Q1I A;  1UMW A;  4O6W A;  3FS3 A;  4CYS A;  2QZU A;  4RS6 A;  4FDJ A;  1F34 B;  3ED4 A;  4J7B B;  4H5X A;  4CYR A;  3P35 A;  2N19 A;  1N2K A;  1E33 P;  1E2T A;  4HY2 A;  4CXU A;  1Q4O A;  1E3C P;  3RQ7 A;  1AUK A;  2IA9 A;  4DFW A;  1N2L A;  2E50 A;  2I9X A;  4CXK A;  4N7Z A;  4WHL A;  1A87 A;  2VKZ G;  5DNJ A;  1HDH A;  3HIH A;  4E9D A;  3P2Z A;  3P37 A;  2I9Z A;  3BZI A;  4NKB A;  4YYP A;  4WHK A;  4N7V A;  3C5L A;  1E2S P;  1F32 A;  2OJX A;  5DMS A;  5DMV C;  4WHH A;  4X9V A;  1FSU A;  4RCP A;  4HAB A;  4N9J A;  4XB0 A;  3FVH A;  3LM3 A;  3P36 A;  4E9C A;  4E67 A;  4X9W A;  5LHZ A;  4G7N A;  3HFD A;  4O56 A;  2UV8 G;  1P49 A;  1Q4K A;  1E1Z P;  4LKL A;  4CXS A;  5J19 A;  3GYV A; 
#chains in the Genus database with same CATH homology
 4J7B B;  4H5X A;  4X9V A;  5DNJ A;  3P35 A;  4RCP A;  2N19 A;  4H71 A;  4HAB A;  3HIH A;  4HY2 A;  3P2W A;  4XB0 A;  4E9D A;  3FVH A;  1Q4O A;  3P2Z A;  3P37 A;  3P36 A;  3RQ7 A;  4E9C A;  4E67 A;  3BZI A;  2OGQ A;  4X9W A;  4YYP A;  4LKM A;  4O9W A;  5LHZ A;  3HIK A;  4DFW A;  4WHK A;  3C5L A;  4X9R A;  4HCO A;  3P34 A;  3Q1I A;  4O56 A;  2OJX A;  1Q4K A;  4LKL A;  1UMW A;  4WHL A;  4O6W A;  5DMS A;  5DMV C;  4RS6 A;  4WHH A;  5J19 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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