3C5WC

Complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme
Total Genus 107
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
304
structure length
294
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPTPDYFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords PP2A A subunit
total genus 107
structure length 294
sequence length 304
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2008-02-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3c5wC00
4LACC 4HD0A 3H67A 4ORCA 4DHLA 3RL5A 1OI8A 2IE4C 2IE3C 2NXFA 3THNA 4H1YP 4KKZA 3K7WC 4V0VA 1KBPA 2USHA 2O8AA 4FBWA 3RL3A 3RL4A 1II7A 2Z72A 3AUZA 3AV0A 3N5UA 1OIEA 5JJTA 3IVEA 4TUGA 2AHDA 3H62B 3V4YA 1G5BA 2NPPC 4ORAA 2GJUA 3PSOA 1TCOA 4NZVA 2Z1AA 1S70A 4Q7FA 3EGGA 4B2OA 3C5WC 1UF3A 2QJCA 4ZX2A 2IAEC 4OR9A 5DNYA 4O24A 5F3WA 1MF8A 2HY1A 3H68A 3H69A 2CV9A 2WDFA 2BDXA 3H66A 1IT6A 4JA9A 2DFJA 2NYLC 4ZVZA 4O4KA 2KKNA 5INBA 1SU1A 1M63A 3FGAC 4XPNA 5GTUA 1QFCA 3RQZA 4H2GA 2P6BA 4FBQA 4JA7A 2ZBMA 2JOGA 3LL8A 3DW8C 4MOYA 4FCXA 2A22A 3EGHA 4ORBA 4DT2A 4I5NC 4H2IA 4DSYA 3IVDA 4MP0A 3ICFA 3IB8A 3PSNA 3QFOA 3QG5C 3E7BA 1T71A 1Z2WA 3P71C 4UT3A 4O5GA 1S8EA 5C1VA 3TGHA 5J28A 1T70A 1XZWA 4H1SA 3QFNA 2WDEA 4LU9A 3C9FA 4J6OA 3H61A 5B8IA 3H63A 2Z06A 2HYOA 2WDDA 5JPEA 5IOHA 4I5LC 3DSCA 3JYFA 4V0WA 1HO5A 3T1IA 4MOVA 3QFMA 1S95A 1WAO1 1NNWA 1HPUA 1FJMA 2QFRA 1S3MA 1V73A 2XMOA 4H2BA 4O43A 5EQVA 2NYMC 1Z2XA 1OIDA 1U32A 1JK7A 3ZTVA 3ZU0A 4G9JA 4UT2A 4M0VA 3H60A 4LTYA 2R17A 2QFPA 2HYPA 4KBPA 3E7AA 2Q8UA 3DSDA 1AUIA 3K7VC 4H2FA 5JPFA 2WDCA 4FBKA 5HPEA 3GVEA 2BCDA 1UTEA 1S3LA 1USHA 3KBPA 3CK2A 1WARA 2O8GA 4UT3B 3THOB 1S3NA 4TUIA 4IL1A 4YKEA 2YVTA 4F0ZA 4IYPC 1QHWA 3HVQA 3QFKA 1XM7A 3H64A 4WWLA 1HP1A 4V0XA 3IB7A 4UWQA 1W24A 2BQ8X
chains in the Genus database with same CATH superfamily
4LACC 4HD0A 3H67A 4ORCA 4DHLA 3RL5A 1OI8A 2IE4C 2IE3C 2NXFA 3THNA 4H1YP 4KKZA 3K7WC 4V0VA 1KBPA 2USHA 2O8AA 4FBWA 3RL3A 3RL4A 1II7A 2Z72A 3AUZA 3AV0A 3N5UA 2ZOAA 1OIEA 5JJTA 3IVEA 4TUGA 2AHDA 3H62B 3V4YA 1G5BA 2NPPC 4ORAA 2GJUA 3PSOA 1TCOA 4NZVA 2Z1AA 1S70A 4Q7FA 3EGGA 4B2OA 3C5WC 1UF3A 2QJCA 4ZX2A 2IAEC 4OR9A 5DNYA 4O24A 5F3WA 1MF8A 2HY1A 3H68A 3H69A 2CV9A 2WDFA 2BDXA 3H66A 1IT6A 4JA9A 2DFJA 2NYLC 4ZVZA 4O4KA 2KKNA 5INBA 1SU1A 1M63A 3FGAC 4XPNA 5GTUA 1QFCA 3RQZA 4H2GA 2P6BA 4FBQA 4JA7A 2ZBMA 2JOGA 3LL8A 3DW8C 4MOYA 4FCXA 2A22A 3EGHA 4ORBA 4DT2A 4I5NC 4H2IA 4DSYA 3IVDA 4MP0A 3ICFA 3IB8A 3PSNA 3QFOA 3QG5C 3E7BA 1T71A 1Z2WA 3P71C 4UT3A 4O5GA 1S8EA 5C1VA 3TGHA 5J28A 1T70A 1XZWA 3E0JA 3QFNA 4H1SA 2WDEA 4LU9A 3C9FA 4J6OA 2DXLA 3H61A 5B8IA 3H63A 2Z06A 2HYOA 3D03A 2WDDA 5JPEA 5IOHA 4I5LC 3DSCA 3JYFA 4V0WA 1HO5A 3T1IA 4MOVA 3QFMA 1S95A 1WAO1 1NNWA 1HPUA 1FJMA 2QFRA 1S3MA 1V73A 2XMOA 4H2BA 4O43A 5EQVA 2NYMC 1Z2XA 1OIDA 1U32A 1JK7A 3ZTVA 3ZU0A 4G9JA 4UT2A 4M0VA 3H60A 4LTYA 2R17A 2QFPA 2YEQA 2HYPA 4KBPA 3E7AA 2DXNA 2Q8UA 3DSDA 1AUIA 3K7VC 4H2FA 5JPFA 2WDCA 4FBKA 5HPEA 3GVEA 2BCDA 1UTEA 1S3LA 1USHA 3KBPA 3CK2A 1WARA 2O8GA 4UT3B 3THOB 1S3NA 4TUIA 4IL1A 4YKEA 2YVTA 4F0ZA 4IYPC 4UWQA 1QHWA 3HVQA 3QFKA 1XM7A 3H64A 4WWLA 1HP1A 4V0XA 3IB7A 3FLOA 2ZO9B 1W24A 2BQ8X
chains in the Genus database with same CATH topology
4LACC 4HD0A 3H67A 4ORCA 4DHLA 3RL5A 1OI8A 2IE4C 2IE3C 2NXFA 3THNA 4H1YP 4KKZA 3K7WC 4V0VA 1KBPA 2USHA 2O8AA 4FBWA 3RL3A 3RL4A 1II7A 2Z72A 3AUZA 3AV0A 3N5UA 2ZOAA 1OIEA 5JJTA 3IVEA 4TUGA 2AHDA 3H62B 3V4YA 1G5BA 2NPPC 4ORAA 2GJUA 3PSOA 1TCOA 4NZVA 2Z1AA 1S70A 4Q7FA 3EGGA 4B2OA 3C5WC 1UF3A 2QJCA 4ZX2A 2IAEC 4OR9A 5DNYA 4O24A 5F3WA 1MF8A 2HY1A 3H68A 3H69A 2CV9A 2WDFA 2BDXA 3H66A 1IT6A 4JA9A 2DFJA 2NYLC 4ZVZA 4O4KA 2KKNA 5INBA 1SU1A 1M63A 3FGAC 4XPNA 5GTUA 1QFCA 3RQZA 4H2GA 2P6BA 4FBQA 4JA7A 2ZBMA 2JOGA 3LL8A 3DW8C 4MOYA 4FCXA 2A22A 3EGHA 4ORBA 4DT2A 4I5NC 4H2IA 4DSYA 3IVDA 4MP0A 3ICFA 3IB8A 3PSNA 3QFOA 3QG5C 3E7BA 1T71A 1Z2WA 3P71C 4UT3A 4O5GA 1S8EA 5C1VA 3TGHA 5J28A 1T70A 1XZWA 3E0JA 3QFNA 4H1SA 2WDEA 4LU9A 3C9FA 4J6OA 2DXLA 3H61A 5B8IA 3H63A 2Z06A 2HYOA 3D03A 2WDDA 5JPEA 5IOHA 4I5LC 3DSCA 3JYFA 4V0WA 1HO5A 3T1IA 4MOVA 3QFMA 1S95A 1WAO1 1NNWA 1HPUA 1FJMA 2QFRA 1S3MA 1V73A 2XMOA 4H2BA 4O43A 5EQVA 2NYMC 1Z2XA 1OIDA 1U32A 1JK7A 3ZTVA 3ZU0A 4G9JA 4UT2A 4M0VA 3H60A 4LTYA 2R17A 2QFPA 2YEQA 2HYPA 4KBPA 3E7AA 2DXNA 2Q8UA 3DSDA 1AUIA 3K7VC 4H2FA 5JPFA 2WDCA 4FBKA 5HPEA 3GVEA 2BCDA 1UTEA 1S3LA 1USHA 3KBPA 3CK2A 1WARA 2O8GA 4UT3B 3THOB 1S3NA 4TUIA 4IL1A 4YKEA 2YVTA 4F0ZA 4IYPC 4UWQA 1QHWA 3HVQA 3QFKA 1XM7A 3H64A 4WWLA 1HP1A 4V0XA 3IB7A 3FLOA 2ZO9B 1W24A 2BQ8X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LAC C;  4HD0 A;  3H67 A;  4ORC A;  4DHL A;  3RL5 A;  1OI8 A;  2IE4 C;  2IE3 C;  2NXF A;  3THN A;  4H1Y P;  4KKZ A;  3K7W C;  4V0V A;  1KBP A;  2USH A;  2O8A A;  4FBW A;  3RL3 A;  3RL4 A;  1II7 A;  2Z72 A;  3AUZ A;  3AV0 A;  3N5U A;  1OIE A;  5JJT A;  3IVE A;  4TUG A;  2AHD A;  3H62 B;  3V4Y A;  1G5B A;  2NPP C;  4ORA A;  2GJU A;  3PSO A;  1TCO A;  4NZV A;  2Z1A A;  1S70 A;  4Q7F A;  3EGG A;  4B2O A;  3C5W C;  1UF3 A;  2QJC A;  4ZX2 A;  2IAE C;  4OR9 A;  5DNY A;  4O24 A;  5F3W A;  1MF8 A;  2HY1 A;  3H68 A;  3H69 A;  2CV9 A;  2WDF A;  2BDX A;  3H66 A;  1IT6 A;  4JA9 A;  2DFJ A;  2NYL C;  4ZVZ A;  4O4K A;  2KKN A;  5INB A;  1SU1 A;  1M63 A;  3FGA C;  4XPN A;  5GTU A;  1QFC A;  3RQZ A;  4H2G A;  2P6B A;  4FBQ A;  4JA7 A;  2ZBM A;  2JOG A;  3LL8 A;  3DW8 C;  4MOY A;  4FCX A;  2A22 A;  3EGH A;  4ORB A;  4DT2 A;  4I5N C;  4H2I A;  4DSY A;  3IVD A;  4MP0 A;  3ICF A;  3IB8 A;  3PSN A;  3QFO A;  3QG5 C;  3E7B A;  1T71 A;  1Z2W A;  3P71 C;  4UT3 A;  4O5G A;  1S8E A;  5C1V A;  3TGH A;  5J28 A;  1T70 A;  1XZW A;  4H1S A;  3QFN A;  2WDE A;  4LU9 A;  3C9F A;  4J6O A;  3H61 A;  5B8I A;  3H63 A;  2Z06 A;  2HYO A;  2WDD A;  5JPE A;  5IOH A;  4I5L C;  3DSC A;  3JYF A;  4V0W A;  1HO5 A;  3T1I A;  4MOV A;  3QFM A;  1S95 A;  1WAO 1;  1NNW A;  1HPU A;  1FJM A;  2QFR A;  1S3M A;  1V73 A;  2XMO A;  4H2B A;  4O43 A;  5EQV A;  2NYM C;  1Z2X A;  1OID A;  1U32 A;  1JK7 A;  3ZTV A;  3ZU0 A;  4G9J A;  4UT2 A;  4M0V A;  3H60 A;  4LTY A;  2R17 A;  2QFP A;  2HYP A;  4KBP A;  3E7A A;  2Q8U A;  3DSD A;  1AUI A;  3K7V C;  4H2F A;  5JPF A;  2WDC A;  4FBK A;  5HPE A;  3GVE A;  2BCD A;  1UTE A;  1S3L A;  1USH A;  3KBP A;  3CK2 A;  1WAR A;  2O8G A;  4UT3 B;  3THO B;  1S3N A;  4TUI A;  4IL1 A;  4YKE A;  2YVT A;  4F0Z A;  4IYP C;  1QHW A;  3HVQ A;  3QFK A;  1XM7 A;  3H64 A;  4WWL A;  1HP1 A;  4V0X A;  3IB7 A;  4UWQ A;  1W24 A;  2BQ8 X; 
#chains in the Genus database with same CATH topology
 4LAC C;  4HD0 A;  3H67 A;  4ORC A;  4DHL A;  3RL5 A;  1OI8 A;  2IE4 C;  2IE3 C;  2NXF A;  3THN A;  4H1Y P;  4KKZ A;  3K7W C;  4V0V A;  1KBP A;  2USH A;  2O8A A;  4FBW A;  3RL3 A;  3RL4 A;  1II7 A;  2Z72 A;  3AUZ A;  3AV0 A;  3N5U A;  2ZOA A;  1OIE A;  5JJT A;  3IVE A;  4TUG A;  2AHD A;  3H62 B;  3V4Y A;  1G5B A;  2NPP C;  4ORA A;  2GJU A;  3PSO A;  1TCO A;  4NZV A;  2Z1A A;  1S70 A;  4Q7F A;  3EGG A;  4B2O A;  3C5W C;  1UF3 A;  2QJC A;  4ZX2 A;  2IAE C;  4OR9 A;  5DNY A;  4O24 A;  5F3W A;  1MF8 A;  2HY1 A;  3H68 A;  3H69 A;  2CV9 A;  2WDF A;  2BDX A;  3H66 A;  1IT6 A;  4JA9 A;  2DFJ A;  2NYL C;  4ZVZ A;  4O4K A;  2KKN A;  5INB A;  1SU1 A;  1M63 A;  3FGA C;  4XPN A;  5GTU A;  1QFC A;  3RQZ A;  4H2G A;  2P6B A;  4FBQ A;  4JA7 A;  2ZBM A;  2JOG A;  3LL8 A;  3DW8 C;  4MOY A;  4FCX A;  2A22 A;  3EGH A;  4ORB A;  4DT2 A;  4I5N C;  4H2I A;  4DSY A;  3IVD A;  4MP0 A;  3ICF A;  3IB8 A;  3PSN A;  3QFO A;  3QG5 C;  3E7B A;  1T71 A;  1Z2W A;  3P71 C;  4UT3 A;  4O5G A;  1S8E A;  5C1V A;  3TGH A;  5J28 A;  1T70 A;  1XZW A;  3E0J A;  3QFN A;  4H1S A;  2WDE A;  4LU9 A;  3C9F A;  4J6O A;  2DXL A;  3H61 A;  5B8I A;  3H63 A;  2Z06 A;  2HYO A;  3D03 A;  2WDD A;  5JPE A;  5IOH A;  4I5L C;  3DSC A;  3JYF A;  4V0W A;  1HO5 A;  3T1I A;  4MOV A;  3QFM A;  1S95 A;  1WAO 1;  1NNW A;  1HPU A;  1FJM A;  2QFR A;  1S3M A;  1V73 A;  2XMO A;  4H2B A;  4O43 A;  5EQV A;  2NYM C;  1Z2X A;  1OID A;  1U32 A;  1JK7 A;  3ZTV A;  3ZU0 A;  4G9J A;  4UT2 A;  4M0V A;  3H60 A;  4LTY A;  2R17 A;  2QFP A;  2YEQ A;  2HYP A;  4KBP A;  3E7A A;  2DXN A;  2Q8U A;  3DSD A;  1AUI A;  3K7V C;  4H2F A;  5JPF A;  2WDC A;  4FBK A;  5HPE A;  3GVE A;  2BCD A;  1UTE A;  1S3L A;  1USH A;  3KBP A;  3CK2 A;  1WAR A;  2O8G A;  4UT3 B;  3THO B;  1S3N A;  4TUI A;  4IL1 A;  4YKE A;  2YVT A;  4F0Z A;  4IYP C;  4UWQ A;  1QHW A;  3HVQ A;  3QFK A;  1XM7 A;  3H64 A;  4WWL A;  1HP1 A;  4V0X A;  3IB7 A;  3FLO A;  2ZO9 B;  1W24 A;  2BQ8 X; 
#chains in the Genus database with same CATH homology
 4LAC C;  4HD0 A;  3H67 A;  4ORC A;  4DHL A;  3RL5 A;  1OI8 A;  2IE4 C;  2IE3 C;  2NXF A;  3THN A;  4H1Y P;  4KKZ A;  3K7W C;  4V0V A;  1KBP A;  2USH A;  2O8A A;  4FBW A;  3RL3 A;  3RL4 A;  1II7 A;  2Z72 A;  3AUZ A;  3AV0 A;  3N5U A;  2ZOA A;  1OIE A;  5JJT A;  3IVE A;  4TUG A;  2AHD A;  3H62 B;  3V4Y A;  1G5B A;  2NPP C;  4ORA A;  2GJU A;  3PSO A;  1TCO A;  4NZV A;  2Z1A A;  1S70 A;  4Q7F A;  3EGG A;  4B2O A;  3C5W C;  1UF3 A;  2QJC A;  4ZX2 A;  2IAE C;  4OR9 A;  5DNY A;  4O24 A;  5F3W A;  1MF8 A;  2HY1 A;  3H68 A;  3H69 A;  2CV9 A;  2WDF A;  2BDX A;  3H66 A;  1IT6 A;  4JA9 A;  2DFJ A;  2NYL C;  4ZVZ A;  4O4K A;  2KKN A;  5INB A;  1SU1 A;  1M63 A;  3FGA C;  4XPN A;  5GTU A;  1QFC A;  3RQZ A;  4H2G A;  2P6B A;  4FBQ A;  4JA7 A;  2ZBM A;  2JOG A;  3LL8 A;  3DW8 C;  4MOY A;  4FCX A;  2A22 A;  3EGH A;  4ORB A;  4DT2 A;  4I5N C;  4H2I A;  4DSY A;  3IVD A;  4MP0 A;  3ICF A;  3IB8 A;  3PSN A;  3QFO A;  3QG5 C;  3E7B A;  1T71 A;  1Z2W A;  3P71 C;  4UT3 A;  4O5G A;  1S8E A;  5C1V A;  3TGH A;  5J28 A;  1T70 A;  1XZW A;  3E0J A;  3QFN A;  4H1S A;  2WDE A;  4LU9 A;  3C9F A;  4J6O A;  2DXL A;  3H61 A;  5B8I A;  3H63 A;  2Z06 A;  2HYO A;  3D03 A;  2WDD A;  5JPE A;  5IOH A;  4I5L C;  3DSC A;  3JYF A;  4V0W A;  1HO5 A;  3T1I A;  4MOV A;  3QFM A;  1S95 A;  1WAO 1;  1NNW A;  1HPU A;  1FJM A;  2QFR A;  1S3M A;  1V73 A;  2XMO A;  4H2B A;  4O43 A;  5EQV A;  2NYM C;  1Z2X A;  1OID A;  1U32 A;  1JK7 A;  3ZTV A;  3ZU0 A;  4G9J A;  4UT2 A;  4M0V A;  3H60 A;  4LTY A;  2R17 A;  2QFP A;  2YEQ A;  2HYP A;  4KBP A;  3E7A A;  2DXN A;  2Q8U A;  3DSD A;  1AUI A;  3K7V C;  4H2F A;  5JPF A;  2WDC A;  4FBK A;  5HPE A;  3GVE A;  2BCD A;  1UTE A;  1S3L A;  1USH A;  3KBP A;  3CK2 A;  1WAR A;  2O8G A;  4UT3 B;  3THO B;  1S3N A;  4TUI A;  4IL1 A;  4YKE A;  2YVT A;  4F0Z A;  4IYP C;  4UWQ A;  1QHW A;  3HVQ A;  3QFK A;  1XM7 A;  3H64 A;  4WWL A;  1HP1 A;  4V0X A;  3IB7 A;  3FLO A;  2ZO9 B;  1W24 A;  2BQ8 X; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...