3C8AA

Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with inhibitory peptide rrgl
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
422
structure length
422
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin A light chain
total genus 147
structure length 422
sequence length 422
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2008-02-11
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3c8aA00
1Z7HA 3DEBA 1ZKXA 3DDBA 3D3XA 2XHLA 3ZUQA 2G7PA 4EJ5A 3QW6A 1G9DA 2W2DA 3QW7A 1ZB7A 1XTFA 1G9BA 3ZUSA 4ELCA 4J1LA 1S0BA 1E1HA 3V0BA 1ZKWA 4HEVA 2G7NA 4KUFA 1I1EA 2A8AA 2QN0A 3BWIA 5BQMA 2ISHA 2IMCA 3BOOA 3V0AA 3BOKA 3NF3A 3QIYA 3V0BB 2NYYA 1S0CA 5BQNA 3FIEA 1S0FA 1ZL6A 3QJ0A 3C89A 3QIZA 3QW8A 2ISGA 2FPQA 3BTAA 1F31A 2G7QA 1XTGA 1F82A 1T3AA 3K3QB 2IMAA 1S0EA 1YVGA 3BONA 1S0GA 2A97A 3VUOA 1G9AA 2ETFA 1ZL5A 3DDAA 1ZN3A 3DSEA 4KTXA 1S0DA 2NP0A 2IMBA 3DS9A 3QIXA 3C8BA 2NZ9A 3V0AB 3FFZA 4ZKTB 2ILPA 4EL4A 3C88A 3FIIA 1T3CA 2ISEA 4ZJXA 4KS6A 3C8AA 1G9CA 2G7KA 3ZURA 3QW5A 1EPWA
chains in the Genus database with same CATH superfamily
1Z7HA 3DEBA 1ZKXA 3DDBA 3D3XA 2XHLA 3ZUQA 2G7PA 4EJ5A 3QW6A 1G9DA 2W2DA 3QW7A 1ZB7A 1XTFA 1G9BA 3ZUSA 4ELCA 3CQBA 4J1LA 1S0BA 1E1HA 3V0BA 1ZKWA 4QHFA 4AW6A 4HEVA 2G7NA 4KUFA 1I1EA 2A8AA 4JIXA 2QN0A 3BWIA 5BQMA 2ISHA 2IMCA 3BOOA 3V0AA 3BOKA 3NF3A 3QIYA 3V0BB 2NYYA 1S0CA 5BQNA 2YPTA 3FIEA 1S0FA 1ZL6A 3QJ0A 3C89A 3QIZA 3QW8A 2ISGA 2FPQA 4IL3A 3BTAA 1F31A 2G7QA 1XTGA 1F82A 1T3AA 3K3QB 2IMAA 1S0EA 1YVGA 3BONA 1S0GA 2A97A 3VUOA 1G9AA 2ETFA 1ZL5A 3DDAA 1ZN3A 3DSEA 4KTXA 4JIUA 1S0DA 2EJQA 2NP0A 2IMBA 3DS9A 3QIXA 3C8BA 2NZ9A 3V0AB 3FFZA 4ZKTB 2ILPA 4EL4A 3C88A 3E11A 3FIIA 1T3CA 2ISEA 4ZJXA 4KS6A 3C8AA 1G9CA 2G7KA 3ZURA 3QW5A 1EPWA
chains in the Genus database with same CATH topology
1Z7HA 3DEBA 1ZKXA 3DDBA 3D3XA 2XHLA 3ZUQA 2G7PA 4EJ5A 3QW6A 1G9DA 2W2DA 3QW7A 1ZB7A 1XTFA 1G9BA 3ZUSA 4ELCA 4J1LA 1S0BA 1E1HA 3V0BA 1ZKWA 4HEVA 2G7NA 4KUFA 1I1EA 2A8AA 2QN0A 3BWIA 5BQMA 2ISHA 2IMCA 3BOOA 3V0AA 3BOKA 3NF3A 3QIYA 3V0BB 2NYYA 1S0CA 5BQNA 3FIEA 1S0FA 1ZL6A 3QJ0A 3C89A 3QIZA 3QW8A 2ISGA 2FPQA 3BTAA 1F31A 2G7QA 1XTGA 1F82A 1T3AA 3K3QB 2IMAA 1S0EA 1YVGA 3BONA 1S0GA 2A97A 3VUOA 1G9AA 2ETFA 1ZL5A 3DDAA 1ZN3A 3DSEA 4KTXA 1S0DA 2NP0A 2IMBA 3DS9A 3QIXA 3C8BA 2NZ9A 3V0AB 3FFZA 4ZKTB 2ILPA 4EL4A 3C88A 3FIIA 1T3CA 2ISEA 4ZJXA 4KS6A 3C8AA 1G9CA 2G7KA 3ZURA 3QW5A 1EPWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z7H A;  3DEB A;  1ZKX A;  3DDB A;  3D3X A;  2XHL A;  3ZUQ A;  2G7P A;  4EJ5 A;  3QW6 A;  1G9D A;  2W2D A;  3QW7 A;  1ZB7 A;  1XTF A;  1G9B A;  3ZUS A;  4ELC A;  4J1L A;  1S0B A;  1E1H A;  3V0B A;  1ZKW A;  4HEV A;  2G7N A;  4KUF A;  1I1E A;  2A8A A;  2QN0 A;  3BWI A;  5BQM A;  2ISH A;  2IMC A;  3BOO A;  3V0A A;  3BOK A;  3NF3 A;  3QIY A;  3V0B B;  2NYY A;  1S0C A;  5BQN A;  3FIE A;  1S0F A;  1ZL6 A;  3QJ0 A;  3C89 A;  3QIZ A;  3QW8 A;  2ISG A;  2FPQ A;  3BTA A;  1F31 A;  2G7Q A;  1XTG A;  1F82 A;  1T3A A;  3K3Q B;  2IMA A;  1S0E A;  1YVG A;  3BON A;  1S0G A;  2A97 A;  3VUO A;  1G9A A;  2ETF A;  1ZL5 A;  3DDA A;  1ZN3 A;  3DSE A;  4KTX A;  1S0D A;  2NP0 A;  2IMB A;  3DS9 A;  3QIX A;  3C8B A;  2NZ9 A;  3V0A B;  3FFZ A;  4ZKT B;  2ILP A;  4EL4 A;  3C88 A;  3FII A;  1T3C A;  2ISE A;  4ZJX A;  4KS6 A;  3C8A A;  1G9C A;  2G7K A;  3ZUR A;  3QW5 A;  1EPW A; 
#chains in the Genus database with same CATH topology
 1Z7H A;  3DEB A;  1ZKX A;  3DDB A;  3D3X A;  2XHL A;  3ZUQ A;  2G7P A;  4EJ5 A;  3QW6 A;  1G9D A;  2W2D A;  3QW7 A;  1ZB7 A;  1XTF A;  1G9B A;  3ZUS A;  4ELC A;  3CQB A;  4J1L A;  1S0B A;  1E1H A;  3V0B A;  1ZKW A;  4QHF A;  4AW6 A;  4HEV A;  2G7N A;  4KUF A;  1I1E A;  2A8A A;  4JIX A;  2QN0 A;  3BWI A;  5BQM A;  2ISH A;  2IMC A;  3BOO A;  3V0A A;  3BOK A;  3NF3 A;  3QIY A;  3V0B B;  2NYY A;  1S0C A;  5BQN A;  2YPT A;  3FIE A;  1S0F A;  1ZL6 A;  3QJ0 A;  3C89 A;  3QIZ A;  3QW8 A;  2ISG A;  2FPQ A;  4IL3 A;  3BTA A;  1F31 A;  2G7Q A;  1XTG A;  1F82 A;  1T3A A;  3K3Q B;  2IMA A;  1S0E A;  1YVG A;  3BON A;  1S0G A;  2A97 A;  3VUO A;  1G9A A;  2ETF A;  1ZL5 A;  3DDA A;  1ZN3 A;  3DSE A;  4KTX A;  4JIU A;  1S0D A;  2EJQ A;  2NP0 A;  2IMB A;  3DS9 A;  3QIX A;  3C8B A;  2NZ9 A;  3V0A B;  3FFZ A;  4ZKT B;  2ILP A;  4EL4 A;  3C88 A;  3E11 A;  3FII A;  1T3C A;  2ISE A;  4ZJX A;  4KS6 A;  3C8A A;  1G9C A;  2G7K A;  3ZUR A;  3QW5 A;  1EPW A; 
#chains in the Genus database with same CATH homology
 1Z7H A;  3DEB A;  1ZKX A;  3DDB A;  3D3X A;  2XHL A;  3ZUQ A;  2G7P A;  4EJ5 A;  3QW6 A;  1G9D A;  2W2D A;  3QW7 A;  1ZB7 A;  1XTF A;  1G9B A;  3ZUS A;  4ELC A;  4J1L A;  1S0B A;  1E1H A;  3V0B A;  1ZKW A;  4HEV A;  2G7N A;  4KUF A;  1I1E A;  2A8A A;  2QN0 A;  3BWI A;  5BQM A;  2ISH A;  2IMC A;  3BOO A;  3V0A A;  3BOK A;  3NF3 A;  3QIY A;  3V0B B;  2NYY A;  1S0C A;  5BQN A;  3FIE A;  1S0F A;  1ZL6 A;  3QJ0 A;  3C89 A;  3QIZ A;  3QW8 A;  2ISG A;  2FPQ A;  3BTA A;  1F31 A;  2G7Q A;  1XTG A;  1F82 A;  1T3A A;  3K3Q B;  2IMA A;  1S0E A;  1YVG A;  3BON A;  1S0G A;  2A97 A;  3VUO A;  1G9A A;  2ETF A;  1ZL5 A;  3DDA A;  1ZN3 A;  3DSE A;  4KTX A;  1S0D A;  2NP0 A;  2IMB A;  3DS9 A;  3QIX A;  3C8B A;  2NZ9 A;  3V0A B;  3FFZ A;  4ZKT B;  2ILP A;  4EL4 A;  3C88 A;  3FII A;  1T3C A;  2ISE A;  4ZJX A;  4KS6 A;  3C8A A;  1G9C A;  2G7K A;  3ZUR A;  3QW5 A;  1EPW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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