3D2HA

Structure of berberine bridge enzyme from eschscholzia californica, monoclinic crystal form
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
498
structure length
498
Chain Sequence
b'DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAGWCPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANFD'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords berberine bridge-forming enzyme
publication title A concerted mechanism for berberine bridge enzyme
pubmed doi rcsb
source organism Eschscholzia californica
molecule tags Oxidoreductase
total genus 166
structure length 498
sequence length 498
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2008-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3d2hA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3d2hA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3d2hA03
2Y4GA 1UXYA 1WYGA 3ETRB 5AE1A 4ML8A 2IPIA 5AE2A 1T3QC 3EUB3 3AMZA 4MLAA 3S1FA 4O95A 2GQUA 2QKNA 5AE3A 2Y3SA 4PWBA 3TSJA 1W1SA 3FW8A 2Q85A 1N63C 2GQTA 3C0PA 3D2DA 2VFSA 2W3SA 3KJMA 1DIQA 1W1OA 2BVFA 1JROA 1DIIA 1W1JA 1E0YA 2BVGA 4ZOHB 2W55A 2Y08A 4PZFA 1N5WC 3B9JB 1W1QA 1FFVC 1I19A 3FW7A 3S1EA 3RJ8A 1E8HA 3GSYA 3SR6B 4BBYA 4BC9A 3W8WA 3FW9A 5HMRA 2MBRA 3NRZB 3S1DA 5ADZA 3BW7A 4DNSA 3PQBA 1WVEA 5HHZA 1N62C 1W1MA 1AHUA 5HQXA 3W8XA 1N60C 1AHVA 1W1LA 1WVFA 2E3TA 2EXRA 4PYTA 1HSKA 1V97A 3NS1B 1QLTA 4OALA 3FWAA 1VAOA 4JAYA 3D2JA 4UD8A 1FO4A 1N61C 3VTEA 1QLUA 2QPMA 4PVJA 3RJAA 4BC7A 1MBTA 2VAOA 1ZXIC 1VDVA 3JS8A 4JB1A 3D2HA 5FXFA 1FFUC 3DQ0A 3W8ZA 1ZR6A 1MBBA 1AHZA 3AN1A 1DZNA 2AXRA 2WDWA 2W54A 3AM9A 5FXDA 1W1RA 3I99A 2Y3RA 1F0XA 3POPA 4PVKA 5L6GA 5L6FA 3PM9A 4PVEA 2VFVA 2I0KA 1E8FA 3HSUA 2VFRA 2BVHA 3TSHA 3NVZB 3S1CA 5I1VA 1N5XA 5FXPA 5D79A 5I1WA 4PVHA 1W1KA 1FIQB 4EC3A 4PWCA 4XLOA 5K8EA 2VFTA 2Q4WA 4BCAA 5AWVA 2W3RA 1E8GA 2VFUA 3TX1A 5FXEA
chains in the Genus database with same CATH superfamily
2Y4GA 1UXYA 5G5GB 1WYGA 3ETRB 5AE1A 4ML8A 2IPIA 5AE2A 1T3QC 3EUB3 3AMZA 4MLAA 3S1FA 4O95A 3NVWB 2GQUA 2QKNA 5AE3A 2Y3SA 4PWBA 3TSJA 1W1SA 3FW8A 2Q85A 1N63C 2GQTA 3C0PA 2O3GA 2PLIA 2R8DA 3HRDC 3D2DA 2VFSA 2W3SA 3KJMA 1DIQA 1W1OA 2BVFA 1JROA 1DIIA 1W1JA 2R2ZA 1E0YA 2BVGA 4ZOHB 2W55A 2Y08A 4PZFA 1N5WC 3B9JB 1W1QA 1FFVC 1I19A 3FW7A 3S1EA 3RJ8A 1E8HA 3GSYA 3SR6B 4BBYA 4BC9A 3W8WA 3FW9A 5HMRA 3NVYB 2MBRA 3NRZB 3S1DA 3LLBA 5ADZA 3BW7A 4DNSA 3PQBA 1WVEA 5HHZA 1N62C 1W1MA 1AHUA 5HQXA 5G5HB 3W8XA 1N60C 3DEDA 4HG0A 1RM6B 3EJEB 1AHVA 1W1LA 1WVFA 2E3TA 2EXRA 4PYTA 3EJDB 1HSKA 1V97A 2YVSA 3NS1B 2NQWA 2UUUA 1QLTA 2RK5A 4OALA 3FWAA 1VAOA 2P3HA 4JAYA 2UUVA 3D2JA 4UD8A 1FO4A 1N61C 3VTEA 2P4PA 1QLUA 2QPMA 4PVJA 3RJAA 4BC7A 1MBTA 2VAOA 1ZXIC 1VDVA 3JS8A 4JB1A 3D2HA 5FXFA 1FFUC 2PLSA 3DQ0A 3W8ZA 1ZR6A 1MBBA 1AHZA 3AN1A 1DZNA 2AXRA 2WDWA 2W54A 3AM9A 5FXDA 3EJBB 1W1RA 3I99A 2Y3RA 1F0XA 3POPA 4PVKA 5L6GA 5L6FA 3LAEA 3PM9A 4PVEA 2VFVA 2I0KA 1E8FA 3HSUA 2VFRA 2BVHA 3TSHA 1SB3B 3NVZB 3S1CA 5I1VA 1N5XA 5FXPA 5D79A 5I1WA 4PVHA 1W1KA 1FIQB 4EC3A 4PWCA 4XLOA 5K8EA 2VFTA 2Q4WA 3NVVB 4BCAA 2P13A 5AWVA 1JRPA 2W3RA 1E8GA 2VFUA 2OAIA 3TX1A 5FXEA
chains in the Genus database with same CATH topology
2Y4GA 1UXYA 5G5GB 1WYGA 3ETRB 5AE1A 4ML8A 2IPIA 5AE2A 1T3QC 3EUB3 3AMZA 4MLAA 3S1FA 4O95A 3NVWB 2GQUA 2QKNA 5AE3A 2Y3SA 4PWBA 3TSJA 1W1SA 3FW8A 2Q85A 1N63C 2GQTA 3C0PA 2O3GA 2PLIA 2R8DA 3HRDC 3D2DA 2VFSA 2W3SA 3KJMA 1DIQA 1W1OA 2BVFA 1JROA 1DIIA 1W1JA 2R2ZA 1E0YA 2BVGA 4ZOHB 2W55A 2Y08A 4PZFA 1N5WC 3B9JB 1W1QA 1FFVC 1I19A 3FW7A 3S1EA 3RJ8A 1E8HA 3GSYA 3SR6B 4BBYA 4BC9A 3W8WA 3FW9A 5HMRA 3NVYB 2MBRA 3NRZB 3S1DA 3LLBA 5ADZA 3BW7A 4DNSA 3PQBA 1WVEA 5HHZA 1N62C 1W1MA 1AHUA 5HQXA 5G5HB 3W8XA 1N60C 3DEDA 4HG0A 1RM6B 1AHVA 1W1LA 1WVFA 2E3TA 2EXRA 4PYTA 1HSKA 1V97A 2YVSA 3NS1B 2NQWA 2UUUA 1QLTA 2RK5A 4OALA 3FWAA 1VAOA 2P3HA 4JAYA 2UUVA 3D2JA 4UD8A 1FO4A 1N61C 3VTEA 2P4PA 1QLUA 2QPMA 4PVJA 3RJAA 4BC7A 1MBTA 2VAOA 1ZXIC 1VDVA 3JS8A 4JB1A 3D2HA 5FXFA 1FFUC 2PLSA 3DQ0A 3W8ZA 1ZR6A 1MBBA 1AHZA 3AN1A 1DZNA 2AXRA 2WDWA 2W54A 3AM9A 5FXDA 1W1RA 3I99A 2Y3RA 1F0XA 3POPA 4PVKA 5L6GA 5L6FA 3LAEA 3PM9A 4PVEA 2VFVA 2I0KA 1E8FA 3HSUA 2VFRA 2BVHA 3TSHA 1SB3B 3NVZB 3S1CA 5I1VA 1N5XA 5FXPA 5D79A 5I1WA 4PVHA 1W1KA 1FIQB 4EC3A 4PWCA 4XLOA 5K8EA 2VFTA 2Q4WA 4BCAA 3NVVB 2P13A 5AWVA 1JRPA 2W3RA 1E8GA 2VFUA 2OAIA 3TX1A 5FXEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Y4G A;  1UXY A;  1WYG A;  3ETR B;  5AE1 A;  4ML8 A;  2IPI A;  5AE2 A;  1T3Q C;  3EUB 3;  3AMZ A;  4MLA A;  3S1F A;  4O95 A;  2GQU A;  2QKN A;  5AE3 A;  2Y3S A;  4PWB A;  3TSJ A;  1W1S A;  3FW8 A;  2Q85 A;  1N63 C;  2GQT A;  3C0P A;  3D2D A;  2VFS A;  2W3S A;  3KJM A;  1DIQ A;  1W1O A;  2BVF A;  1JRO A;  1DII A;  1W1J A;  1E0Y A;  2BVG A;  4ZOH B;  2W55 A;  2Y08 A;  4PZF A;  1N5W C;  3B9J B;  1W1Q A;  1FFV C;  1I19 A;  3FW7 A;  3S1E A;  3RJ8 A;  1E8H A;  3GSY A;  3SR6 B;  4BBY A;  4BC9 A;  3W8W A;  3FW9 A;  5HMR A;  2MBR A;  3NRZ B;  3S1D A;  5ADZ A;  3BW7 A;  4DNS A;  3PQB A;  1WVE A;  5HHZ A;  1N62 C;  1W1M A;  1AHU A;  5HQX A;  3W8X A;  1N60 C;  1AHV A;  1W1L A;  1WVF A;  2E3T A;  2EXR A;  4PYT A;  1HSK A;  1V97 A;  3NS1 B;  1QLT A;  4OAL A;  3FWA A;  1VAO A;  4JAY A;  3D2J A;  4UD8 A;  1FO4 A;  1N61 C;  3VTE A;  1QLU A;  2QPM A;  4PVJ A;  3RJA A;  4BC7 A;  1MBT A;  2VAO A;  1ZXI C;  1VDV A;  3JS8 A;  4JB1 A;  3D2H A;  5FXF A;  1FFU C;  3DQ0 A;  3W8Z A;  1ZR6 A;  1MBB A;  1AHZ A;  3AN1 A;  1DZN A;  2AXR A;  2WDW A;  2W54 A;  3AM9 A;  5FXD A;  1W1R A;  3I99 A;  2Y3R A;  1F0X A;  3POP A;  4PVK A;  5L6G A;  5L6F A;  3PM9 A;  4PVE A;  2VFV A;  2I0K A;  1E8F A;  3HSU A;  2VFR A;  2BVH A;  3TSH A;  3NVZ B;  3S1C A;  5I1V A;  1N5X A;  5FXP A;  5D79 A;  5I1W A;  4PVH A;  1W1K A;  1FIQ B;  4EC3 A;  4PWC A;  4XLO A;  5K8E A;  2VFT A;  2Q4W A;  4BCA A;  5AWV A;  2W3R A;  1E8G A;  2VFU A;  3TX1 A;  5FXE A; 
#chains in the Genus database with same CATH topology
 2Y4G A;  1UXY A;  5G5G B;  1WYG A;  3ETR B;  5AE1 A;  4ML8 A;  2IPI A;  5AE2 A;  1T3Q C;  3EUB 3;  3AMZ A;  4MLA A;  3S1F A;  4O95 A;  3NVW B;  2GQU A;  2QKN A;  5AE3 A;  2Y3S A;  4PWB A;  3TSJ A;  1W1S A;  3FW8 A;  2Q85 A;  1N63 C;  2GQT A;  3C0P A;  2O3G A;  2PLI A;  2R8D A;  3HRD C;  3D2D A;  2VFS A;  2W3S A;  3KJM A;  1DIQ A;  1W1O A;  2BVF A;  1JRO A;  1DII A;  1W1J A;  2R2Z A;  1E0Y A;  2BVG A;  4ZOH B;  2W55 A;  2Y08 A;  4PZF A;  1N5W C;  3B9J B;  1W1Q A;  1FFV C;  1I19 A;  3FW7 A;  3S1E A;  3RJ8 A;  1E8H A;  3GSY A;  3SR6 B;  4BBY A;  4BC9 A;  3W8W A;  3FW9 A;  5HMR A;  3NVY B;  2MBR A;  3NRZ B;  3S1D A;  3LLB A;  5ADZ A;  3BW7 A;  4DNS A;  3PQB A;  1WVE A;  5HHZ A;  1N62 C;  1W1M A;  1AHU A;  5HQX A;  5G5H B;  3W8X A;  1N60 C;  3DED A;  4HG0 A;  1RM6 B;  3EJE B;  1AHV A;  1W1L A;  1WVF A;  2E3T A;  2EXR A;  4PYT A;  3EJD B;  1HSK A;  1V97 A;  2YVS A;  3NS1 B;  2NQW A;  2UUU A;  1QLT A;  2RK5 A;  4OAL A;  3FWA A;  1VAO A;  2P3H A;  4JAY A;  2UUV A;  3D2J A;  4UD8 A;  1FO4 A;  1N61 C;  3VTE A;  2P4P A;  1QLU A;  2QPM A;  4PVJ A;  3RJA A;  4BC7 A;  1MBT A;  2VAO A;  1ZXI C;  1VDV A;  3JS8 A;  4JB1 A;  3D2H A;  5FXF A;  1FFU C;  2PLS A;  3DQ0 A;  3W8Z A;  1ZR6 A;  1MBB A;  1AHZ A;  3AN1 A;  1DZN A;  2AXR A;  2WDW A;  2W54 A;  3AM9 A;  5FXD A;  3EJB B;  1W1R A;  3I99 A;  2Y3R A;  1F0X A;  3POP A;  4PVK A;  5L6G A;  5L6F A;  3LAE A;  3PM9 A;  4PVE A;  2VFV A;  2I0K A;  1E8F A;  3HSU A;  2VFR A;  2BVH A;  3TSH A;  1SB3 B;  3NVZ B;  3S1C A;  5I1V A;  1N5X A;  5FXP A;  5D79 A;  5I1W A;  4PVH A;  1W1K A;  1FIQ B;  4EC3 A;  4PWC A;  4XLO A;  5K8E A;  2VFT A;  2Q4W A;  3NVV B;  4BCA A;  2P13 A;  5AWV A;  1JRP A;  2W3R A;  1E8G A;  2VFU A;  2OAI A;  3TX1 A;  5FXE A; 
#chains in the Genus database with same CATH homology
 2Y4G A;  1UXY A;  5G5G B;  1WYG A;  3ETR B;  5AE1 A;  4ML8 A;  2IPI A;  5AE2 A;  1T3Q C;  3EUB 3;  3AMZ A;  4MLA A;  3S1F A;  4O95 A;  3NVW B;  2GQU A;  2QKN A;  5AE3 A;  2Y3S A;  4PWB A;  3TSJ A;  1W1S A;  3FW8 A;  2Q85 A;  1N63 C;  2GQT A;  3C0P A;  2O3G A;  2PLI A;  2R8D A;  3HRD C;  3D2D A;  2VFS A;  2W3S A;  3KJM A;  1DIQ A;  1W1O A;  2BVF A;  1JRO A;  1DII A;  1W1J A;  2R2Z A;  1E0Y A;  2BVG A;  4ZOH B;  2W55 A;  2Y08 A;  4PZF A;  1N5W C;  3B9J B;  1W1Q A;  1FFV C;  1I19 A;  3FW7 A;  3S1E A;  3RJ8 A;  1E8H A;  3GSY A;  3SR6 B;  4BBY A;  4BC9 A;  3W8W A;  3FW9 A;  5HMR A;  3NVY B;  2MBR A;  3NRZ B;  3S1D A;  3LLB A;  5ADZ A;  3BW7 A;  4DNS A;  3PQB A;  1WVE A;  5HHZ A;  1N62 C;  1W1M A;  1AHU A;  5HQX A;  5G5H B;  3W8X A;  1N60 C;  3DED A;  4HG0 A;  1RM6 B;  1AHV A;  1W1L A;  1WVF A;  2E3T A;  2EXR A;  4PYT A;  1HSK A;  1V97 A;  2YVS A;  3NS1 B;  2NQW A;  2UUU A;  1QLT A;  2RK5 A;  4OAL A;  3FWA A;  1VAO A;  2P3H A;  4JAY A;  2UUV A;  3D2J A;  4UD8 A;  1FO4 A;  1N61 C;  3VTE A;  2P4P A;  1QLU A;  2QPM A;  4PVJ A;  3RJA A;  4BC7 A;  1MBT A;  2VAO A;  1ZXI C;  1VDV A;  3JS8 A;  4JB1 A;  3D2H A;  5FXF A;  1FFU C;  2PLS A;  3DQ0 A;  3W8Z A;  1ZR6 A;  1MBB A;  1AHZ A;  3AN1 A;  1DZN A;  2AXR A;  2WDW A;  2W54 A;  3AM9 A;  5FXD A;  1W1R A;  3I99 A;  2Y3R A;  1F0X A;  3POP A;  4PVK A;  5L6G A;  5L6F A;  3LAE A;  3PM9 A;  4PVE A;  2VFV A;  2I0K A;  1E8F A;  3HSU A;  2VFR A;  2BVH A;  3TSH A;  1SB3 B;  3NVZ B;  3S1C A;  5I1V A;  1N5X A;  5FXP A;  5D79 A;  5I1W A;  4PVH A;  1W1K A;  1FIQ B;  4EC3 A;  4PWC A;  4XLO A;  5K8E A;  2VFT A;  2Q4W A;  4BCA A;  3NVV B;  2P13 A;  5AWV A;  1JRP A;  2W3R A;  1E8G A;  2VFU A;  2OAI A;  3TX1 A;  5FXE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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