3D2HA

Structure of berberine bridge enzyme from eschscholzia californica, monoclinic crystal form
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
498
structure length
498
Chain Sequence
DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAGWCPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANFD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A concerted mechanism for berberine bridge enzyme
pubmed doi rcsb
source organism Eschscholzia californica
molecule tags Oxidoreductase
molecule keywords berberine bridge-forming enzyme
total genus 166
structure length 498
sequence length 498
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2008-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3d2hA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3d2hA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3d2hA03
1N60C 3KJMA 3S1EA 3TSHA 1W1MA 5L6FA 1DIIA 4PZFA 5FXPA 2E3TA 4O95A 3RJAA 2Y08A 1WVEA 5HHZA 1E0YA 2BVHA 3RJ8A 2VFUA 3W8XA 4ML8A 1ZXIC 3ETRB 4PVKA 3D2HA 2W3SA 4OALA 5AE2A 3FW8A 3JS8A 1DZNA 2Q4WA 3D2JA 2VAOA 3B9JB 4DNSA 3FW7A 3I99A 5D79A 3NRZB 4BCAA 2AXRA 2VFTA 4EC3A 5AE1A 1N63C 1W1SA 3HSUA 1E8GA 1FFUC 3PQBA 3DQ0A 1AHZA 2QKNA 3PM9A 1VAOA 4UD8A 1AHUA 1WVFA 4PWBA 2Y4GA 4PVHA 2W55A 4PWCA 3FWAA 5FXDA 4BC7A 2I0KA 1QLTA 2VFRA 3AN1A 1E8FA 5K8EA 5HMRA 3S1DA 1HSKA 2WDWA 4BC9A 1AHVA 1W1RA 1FIQB 3TX1A 3AM9A 3NVZB 1UXYA 1DIQA 2BVGA 1N5XA 1W1OA 2Y3RA 2GQTA 1W1KA 4JAYA 1F0XA 5L6GA 4PYTA 3W8WA 1JROA 1MBTA 4PVJA 5HQXA 1W1LA 3VTEA 1N5WC 1MBBA 4PVEA 5I1WA 1I19A 1FO4A 2GQUA 3EUB3 1V97A 1QLUA 1E8HA 3SR6B 1N62C 3AMZA 1FFVC 2VFVA 5AWVA 1W1JA 1ZR6A 4XLOA 1WYGA 4MLAA 1T3QC 5FXFA 2Y3SA 1VDVA 3POPA 3S1FA 3S1CA 2W3RA 4BBYA 2MBRA 3FW9A 5FXEA 2Q85A 3NS1B 3GSYA 3D2DA 2EXRA 3BW7A 3TSJA 3C0PA 1N61C 5I1VA 2VFSA 2QPMA 2W54A 3W8ZA 5ADZA 5AE3A 2BVFA 4JB1A 2IPIA 1W1QA 4ZOHB
chains in the Genus database with same CATH superfamily
1N60C 3KJMA 3S1EA 3TSHA 1W1MA 5L6FA 1DIIA 4PZFA 5FXPA 2E3TA 1SB3B 4O95A 3RJAA 2Y08A 5G5GB 3NVVB 2P13A 1WVEA 5HHZA 1E0YA 2BVHA 3DEDA 4HG0A 5G5HB 3RJ8A 2VFUA 3W8XA 4ML8A 1ZXIC 3ETRB 4PVKA 3D2HA 2W3SA 4OALA 2UUVA 1JRPA 5AE2A 3FW8A 3JS8A 1DZNA 2Q4WA 3EJDB 3HRDC 3D2JA 2VAOA 3B9JB 4DNSA 3FW7A 3I99A 5D79A 3NRZB 4BCAA 2AXRA 2VFTA 4EC3A 5AE1A 1N63C 1W1SA 2PLIA 1E8GA 2RK5A 3HSUA 1FFUC 3EJEB 3PQBA 3DQ0A 1AHZA 2QKNA 3PM9A 1VAOA 4UD8A 1AHUA 1WVFA 4PWBA 2Y4GA 4PVHA 2W55A 4PWCA 2PLSA 3FWAA 5FXDA 4BC7A 2I0KA 1QLTA 2P3HA 2VFRA 3NVWB 3AN1A 1E8FA 5K8EA 5HMRA 2YVSA 3S1DA 1HSKA 2WDWA 4BC9A 1AHVA 1W1RA 1FIQB 3TX1A 3AM9A 3NVZB 1UXYA 1DIQA 3EJBB 2BVGA 1N5XA 1W1OA 2Y3RA 2GQTA 1W1KA 3LAEA 4JAYA 2R2ZA 1F0XA 5L6GA 4PYTA 3LLBA 3W8WA 2OAIA 1JROA 2NQWA 1MBTA 4PVJA 5HQXA 1W1LA 3VTEA 1N5WC 1MBBA 4PVEA 5I1WA 2R8DA 3NVYB 1I19A 1FO4A 2GQUA 3EUB3 1V97A 1QLUA 1E8HA 3SR6B 1N62C 3AMZA 1FFVC 2UUUA 2VFVA 5AWVA 2O3GA 1W1JA 1ZR6A 4XLOA 1WYGA 4MLAA 1T3QC 5FXFA 2Y3SA 1VDVA 3POPA 1RM6B 3S1FA 3S1CA 2W3RA 4BBYA 2MBRA 3FW9A 5FXEA 2Q85A 3NS1B 3GSYA 3D2DA 2EXRA 3BW7A 3TSJA 3C0PA 1N61C 2P4PA 2VFSA 5I1VA 2QPMA 2W54A 3W8ZA 5ADZA 5AE3A 2BVFA 4JB1A 2IPIA 1W1QA 4ZOHB
chains in the Genus database with same CATH topology
1N60C 3KJMA 3S1EA 3TSHA 1W1MA 5L6FA 1DIIA 4PZFA 5FXPA 2E3TA 1SB3B 4O95A 3RJAA 2Y08A 5G5GB 3NVVB 2P13A 1WVEA 5HHZA 1E0YA 2BVHA 3DEDA 4HG0A 5G5HB 3RJ8A 2VFUA 3W8XA 4ML8A 1ZXIC 3ETRB 4PVKA 3D2HA 2W3SA 4OALA 2UUVA 1JRPA 5AE2A 3FW8A 3JS8A 1DZNA 2Q4WA 3HRDC 3D2JA 2VAOA 3B9JB 4DNSA 3FW7A 3I99A 5D79A 3NRZB 4BCAA 2AXRA 2VFTA 4EC3A 5AE1A 1N63C 1W1SA 2PLIA 1E8GA 2RK5A 3HSUA 1FFUC 3PQBA 3DQ0A 1AHZA 2QKNA 3PM9A 1VAOA 4UD8A 1AHUA 1WVFA 4PWBA 2Y4GA 4PVHA 2W55A 4PWCA 2PLSA 3FWAA 5FXDA 4BC7A 2I0KA 1QLTA 2P3HA 2VFRA 3NVWB 3AN1A 1E8FA 5K8EA 5HMRA 2YVSA 3S1DA 1HSKA 2WDWA 4BC9A 1AHVA 1W1RA 1FIQB 3TX1A 3AM9A 3NVZB 1UXYA 1DIQA 2BVGA 1N5XA 1W1OA 2Y3RA 2GQTA 1W1KA 3LAEA 4JAYA 2R2ZA 1F0XA 5L6GA 4PYTA 3LLBA 3W8WA 2OAIA 1JROA 2NQWA 1MBTA 4PVJA 5HQXA 1W1LA 3VTEA 1N5WC 1MBBA 4PVEA 5I1WA 2R8DA 3NVYB 1I19A 1FO4A 2GQUA 3EUB3 1V97A 1QLUA 1E8HA 3SR6B 1N62C 3AMZA 1FFVC 2UUUA 2VFVA 5AWVA 2O3GA 1W1JA 1ZR6A 4XLOA 1WYGA 4MLAA 1T3QC 5FXFA 2Y3SA 1VDVA 3POPA 1RM6B 3S1FA 3S1CA 2W3RA 4BBYA 2MBRA 3FW9A 5FXEA 2Q85A 3NS1B 3GSYA 3D2DA 2EXRA 3BW7A 3TSJA 3C0PA 1N61C 2P4PA 2VFSA 5I1VA 2QPMA 2W54A 3W8ZA 5ADZA 5AE3A 2BVFA 4JB1A 2IPIA 1W1QA 4ZOHB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N60 C;  3KJM A;  3S1E A;  3TSH A;  1W1M A;  5L6F A;  1DII A;  4PZF A;  5FXP A;  2E3T A;  4O95 A;  3RJA A;  2Y08 A;  1WVE A;  5HHZ A;  1E0Y A;  2BVH A;  3RJ8 A;  2VFU A;  3W8X A;  4ML8 A;  1ZXI C;  3ETR B;  4PVK A;  3D2H A;  2W3S A;  4OAL A;  5AE2 A;  3FW8 A;  3JS8 A;  1DZN A;  2Q4W A;  3D2J A;  2VAO A;  3B9J B;  4DNS A;  3FW7 A;  3I99 A;  5D79 A;  3NRZ B;  4BCA A;  2AXR A;  2VFT A;  4EC3 A;  5AE1 A;  1N63 C;  1W1S A;  3HSU A;  1E8G A;  1FFU C;  3PQB A;  3DQ0 A;  1AHZ A;  2QKN A;  3PM9 A;  1VAO A;  4UD8 A;  1AHU A;  1WVF A;  4PWB A;  2Y4G A;  4PVH A;  2W55 A;  4PWC A;  3FWA A;  5FXD A;  4BC7 A;  2I0K A;  1QLT A;  2VFR A;  3AN1 A;  1E8F A;  5K8E A;  5HMR A;  3S1D A;  1HSK A;  2WDW A;  4BC9 A;  1AHV A;  1W1R A;  1FIQ B;  3TX1 A;  3AM9 A;  3NVZ B;  1UXY A;  1DIQ A;  2BVG A;  1N5X A;  1W1O A;  2Y3R A;  2GQT A;  1W1K A;  4JAY A;  1F0X A;  5L6G A;  4PYT A;  3W8W A;  1JRO A;  1MBT A;  4PVJ A;  5HQX A;  1W1L A;  3VTE A;  1N5W C;  1MBB A;  4PVE A;  5I1W A;  1I19 A;  1FO4 A;  2GQU A;  3EUB 3;  1V97 A;  1QLU A;  1E8H A;  3SR6 B;  1N62 C;  3AMZ A;  1FFV C;  2VFV A;  5AWV A;  1W1J A;  1ZR6 A;  4XLO A;  1WYG A;  4MLA A;  1T3Q C;  5FXF A;  2Y3S A;  1VDV A;  3POP A;  3S1F A;  3S1C A;  2W3R A;  4BBY A;  2MBR A;  3FW9 A;  5FXE A;  2Q85 A;  3NS1 B;  3GSY A;  3D2D A;  2EXR A;  3BW7 A;  3TSJ A;  3C0P A;  1N61 C;  5I1V A;  2VFS A;  2QPM A;  2W54 A;  3W8Z A;  5ADZ A;  5AE3 A;  2BVF A;  4JB1 A;  2IPI A;  1W1Q A;  4ZOH B; 
#chains in the Genus database with same CATH topology
 1N60 C;  3KJM A;  3S1E A;  3TSH A;  1W1M A;  5L6F A;  1DII A;  4PZF A;  5FXP A;  2E3T A;  1SB3 B;  4O95 A;  3RJA A;  2Y08 A;  5G5G B;  3NVV B;  2P13 A;  1WVE A;  5HHZ A;  1E0Y A;  2BVH A;  3DED A;  4HG0 A;  5G5H B;  3RJ8 A;  2VFU A;  3W8X A;  4ML8 A;  1ZXI C;  3ETR B;  4PVK A;  3D2H A;  2W3S A;  4OAL A;  2UUV A;  1JRP A;  5AE2 A;  3FW8 A;  3JS8 A;  1DZN A;  2Q4W A;  3EJD B;  3HRD C;  3D2J A;  2VAO A;  3B9J B;  4DNS A;  3FW7 A;  3I99 A;  5D79 A;  3NRZ B;  4BCA A;  2AXR A;  2VFT A;  4EC3 A;  5AE1 A;  1N63 C;  1W1S A;  2PLI A;  1E8G A;  2RK5 A;  3HSU A;  1FFU C;  3EJE B;  3PQB A;  3DQ0 A;  1AHZ A;  2QKN A;  3PM9 A;  1VAO A;  4UD8 A;  1AHU A;  1WVF A;  4PWB A;  2Y4G A;  4PVH A;  2W55 A;  4PWC A;  2PLS A;  3FWA A;  5FXD A;  4BC7 A;  2I0K A;  1QLT A;  2P3H A;  2VFR A;  3NVW B;  3AN1 A;  1E8F A;  5K8E A;  5HMR A;  2YVS A;  3S1D A;  1HSK A;  2WDW A;  4BC9 A;  1AHV A;  1W1R A;  1FIQ B;  3TX1 A;  3AM9 A;  3NVZ B;  1UXY A;  1DIQ A;  3EJB B;  2BVG A;  1N5X A;  1W1O A;  2Y3R A;  2GQT A;  1W1K A;  3LAE A;  4JAY A;  2R2Z A;  1F0X A;  5L6G A;  4PYT A;  3LLB A;  3W8W A;  2OAI A;  1JRO A;  2NQW A;  1MBT A;  4PVJ A;  5HQX A;  1W1L A;  3VTE A;  1N5W C;  1MBB A;  4PVE A;  5I1W A;  2R8D A;  3NVY B;  1I19 A;  1FO4 A;  2GQU A;  3EUB 3;  1V97 A;  1QLU A;  1E8H A;  3SR6 B;  1N62 C;  3AMZ A;  1FFV C;  2UUU A;  2VFV A;  5AWV A;  2O3G A;  1W1J A;  1ZR6 A;  4XLO A;  1WYG A;  4MLA A;  1T3Q C;  5FXF A;  2Y3S A;  1VDV A;  3POP A;  1RM6 B;  3S1F A;  3S1C A;  2W3R A;  4BBY A;  2MBR A;  3FW9 A;  5FXE A;  2Q85 A;  3NS1 B;  3GSY A;  3D2D A;  2EXR A;  3BW7 A;  3TSJ A;  3C0P A;  1N61 C;  2P4P A;  2VFS A;  5I1V A;  2QPM A;  2W54 A;  3W8Z A;  5ADZ A;  5AE3 A;  2BVF A;  4JB1 A;  2IPI A;  1W1Q A;  4ZOH B; 
#chains in the Genus database with same CATH homology
 1N60 C;  3KJM A;  3S1E A;  3TSH A;  1W1M A;  5L6F A;  1DII A;  4PZF A;  5FXP A;  2E3T A;  1SB3 B;  4O95 A;  3RJA A;  2Y08 A;  5G5G B;  3NVV B;  2P13 A;  1WVE A;  5HHZ A;  1E0Y A;  2BVH A;  3DED A;  4HG0 A;  5G5H B;  3RJ8 A;  2VFU A;  3W8X A;  4ML8 A;  1ZXI C;  3ETR B;  4PVK A;  3D2H A;  2W3S A;  4OAL A;  2UUV A;  1JRP A;  5AE2 A;  3FW8 A;  3JS8 A;  1DZN A;  2Q4W A;  3HRD C;  3D2J A;  2VAO A;  3B9J B;  4DNS A;  3FW7 A;  3I99 A;  5D79 A;  3NRZ B;  4BCA A;  2AXR A;  2VFT A;  4EC3 A;  5AE1 A;  1N63 C;  1W1S A;  2PLI A;  1E8G A;  2RK5 A;  3HSU A;  1FFU C;  3PQB A;  3DQ0 A;  1AHZ A;  2QKN A;  3PM9 A;  1VAO A;  4UD8 A;  1AHU A;  1WVF A;  4PWB A;  2Y4G A;  4PVH A;  2W55 A;  4PWC A;  2PLS A;  3FWA A;  5FXD A;  4BC7 A;  2I0K A;  1QLT A;  2P3H A;  2VFR A;  3NVW B;  3AN1 A;  1E8F A;  5K8E A;  5HMR A;  2YVS A;  3S1D A;  1HSK A;  2WDW A;  4BC9 A;  1AHV A;  1W1R A;  1FIQ B;  3TX1 A;  3AM9 A;  3NVZ B;  1UXY A;  1DIQ A;  2BVG A;  1N5X A;  1W1O A;  2Y3R A;  2GQT A;  1W1K A;  3LAE A;  4JAY A;  2R2Z A;  1F0X A;  5L6G A;  4PYT A;  3LLB A;  3W8W A;  2OAI A;  1JRO A;  2NQW A;  1MBT A;  4PVJ A;  5HQX A;  1W1L A;  3VTE A;  1N5W C;  1MBB A;  4PVE A;  5I1W A;  2R8D A;  3NVY B;  1I19 A;  1FO4 A;  2GQU A;  3EUB 3;  1V97 A;  1QLU A;  1E8H A;  3SR6 B;  1N62 C;  3AMZ A;  1FFV C;  2UUU A;  2VFV A;  5AWV A;  2O3G A;  1W1J A;  1ZR6 A;  4XLO A;  1WYG A;  4MLA A;  1T3Q C;  5FXF A;  2Y3S A;  1VDV A;  3POP A;  1RM6 B;  3S1F A;  3S1C A;  2W3R A;  4BBY A;  2MBR A;  3FW9 A;  5FXE A;  2Q85 A;  3NS1 B;  3GSY A;  3D2D A;  2EXR A;  3BW7 A;  3TSJ A;  3C0P A;  1N61 C;  2P4P A;  2VFS A;  5I1V A;  2QPM A;  2W54 A;  3W8Z A;  5ADZ A;  5AE3 A;  2BVF A;  4JB1 A;  2IPI A;  1W1Q A;  4ZOH B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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