3D2HA

Structure of berberine bridge enzyme from eschscholzia californica, monoclinic crystal form
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
498
structure length
498
Chain Sequence
DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAGWCPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANFD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords berberine bridge-forming enzyme
publication title A concerted mechanism for berberine bridge enzyme
pubmed doi rcsb
source organism Eschscholzia californica
molecule tags Oxidoreductase
total genus 166
structure length 498
sequence length 498
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2008-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3d2hA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3d2hA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3d2hA03
3NRZB 1T3QC 4BBYA 1W1RA 2VAOA 5AE2A 5I1WA 2QKNA 3PQBA 5FXEA 3RJ8A 3HSUA 5AE1A 3AN1A 2Y08A 2MBRA 3NS1B 4ML8A 4BC9A 3S1FA 3S1EA 3FW9A 2IPIA 1W1OA 4PYTA 1WVEA 4JB1A 1N5XA 4JAYA 5HHZA 1W1LA 3JS8A 1MBBA 1WYGA 3W8ZA 1E8GA 2GQTA 2VFUA 1QLTA 4PWCA 2VFRA 1DIQA 4PVJA 2QPMA 2EXRA 3AM9A 4PZFA 5FXFA 3FW7A 1JROA 3S1DA 1HSKA 3S1CA 4PVEA 2W54A 3TSJA 1AHVA 3KJMA 3NVZB 1I19A 3SR6B 1FFUC 1DIIA 5HMRA 4EC3A 4OALA 2BVFA 3W8XA 1ZXIC 4PWBA 1AHUA 4ZOHB 3D2DA 1N61C 2I0KA 3TSHA 1VDVA 2WDWA 2Y3SA 3C0PA 4BCAA 1E8FA 5AWVA 4UD8A 5HQXA 4O95A 2E3TA 3ETRB 3VTEA 5L6GA 2BVHA 1AHZA 1V97A 1UXYA 2W3RA 2W3SA 1VAOA 2Q85A 5L6FA 3D2HA 1QLUA 2GQUA 1W1JA 4PVHA 1ZR6A 4PVKA 3RJAA 4MLAA 3D2JA 1N62C 2BVGA 5AE3A 2Y4GA 3PM9A 3DQ0A 3TX1A 1FFVC 5ADZA 3B9JB 1N60C 1W1QA 4BC7A 2Y3RA 5D79A 3AMZA 1E8HA 2AXRA 1FO4A 1E0YA 3BW7A 2VFSA 2Q4WA 1MBTA 3I99A 3FWAA 1FIQB 4XLOA 4DNSA 1F0XA 5FXDA 2W55A 3GSYA 5FXPA 1DZNA 1W1MA 1W1KA 3FW8A 1N5WC 3EUB3 1N63C 2VFVA 3POPA 1WVFA 3W8WA 1W1SA 5I1VA 5K8EA 2VFTA
chains in the Genus database with same CATH superfamily
3NRZB 1T3QC 4BBYA 1W1RA 2VAOA 5AE2A 5I1WA 2QKNA 2PLSA 5FXEA 3PQBA 1JRPA 1RM6B 3HSUA 3RJ8A 3LAEA 5AE1A 2P13A 2OAIA 3AN1A 2Y08A 2MBRA 3NS1B 4ML8A 3HRDC 2UUUA 4BC9A 3S1FA 3S1EA 3LLBA 3FW9A 2IPIA 1W1OA 2P3HA 4PYTA 1WVEA 4JB1A 1N5XA 4JAYA 2RK5A 5HHZA 1W1LA 3JS8A 1MBBA 1WYGA 3W8ZA 1E8GA 2GQTA 2VFUA 1QLTA 2PLIA 4PWCA 2VFRA 1DIQA 4PVJA 5G5HB 2QPMA 2EXRA 3AM9A 4PZFA 4HG0A 5FXFA 3FW7A 1JROA 2O3GA 2R2ZA 3S1DA 1HSKA 3S1CA 4PVEA 2W54A 3TSJA 1AHVA 3KJMA 3NVZB 1I19A 3SR6B 1FFUC 1DIIA 5HMRA 4EC3A 4OALA 2BVFA 3W8XA 1ZXIC 4PWBA 1AHUA 4ZOHB 3D2DA 1N61C 2I0KA 3TSHA 1VDVA 3NVWB 2WDWA 3C0PA 2Y3SA 4BCAA 1E8FA 5AWVA 4UD8A 5HQXA 4O95A 2E3TA 3ETRB 3VTEA 5L6GA 2BVHA 1AHZA 1V97A 1UXYA 2W3RA 2W3SA 1VAOA 2Q85A 5L6FA 3D2HA 1QLUA 2GQUA 1W1JA 4PVHA 1ZR6A 4PVKA 3RJAA 4MLAA 3D2JA 1N62C 2BVGA 2NQWA 5AE3A 2Y4GA 2R8DA 3PM9A 3DQ0A 3TX1A 1FFVC 3NVVB 5ADZA 3EJBB 3B9JB 1N60C 2YVSA 1W1QA 4BC7A 2UUVA 2Y3RA 5D79A 3AMZA 5G5GB 1E8HA 2AXRA 1FO4A 2P4PA 1E0YA 3BW7A 2VFSA 2Q4WA 1SB3B 3DEDA 1MBTA 3I99A 3FWAA 1FIQB 4XLOA 4DNSA 1F0XA 5FXDA 2W55A 3GSYA 5FXPA 1DZNA 1W1MA 1W1KA 3FW8A 1N5WC 3EUB3 1N63C 3EJEB 3EJDB 2VFVA 3POPA 1WVFA 3W8WA 1W1SA 3NVYB 5I1VA 5K8EA 2VFTA
chains in the Genus database with same CATH topology
3NRZB 1T3QC 4BBYA 1W1RA 2VAOA 5AE2A 5I1WA 2QKNA 2PLSA 5FXEA 3PQBA 1JRPA 1RM6B 3HSUA 3RJ8A 3LAEA 5AE1A 2P13A 2OAIA 3AN1A 2Y08A 2MBRA 3NS1B 4ML8A 3HRDC 2UUUA 4BC9A 3S1FA 3S1EA 3LLBA 3FW9A 2IPIA 1W1OA 2P3HA 4PYTA 1WVEA 4JB1A 1N5XA 4JAYA 2RK5A 5HHZA 1W1LA 3JS8A 1MBBA 1WYGA 3W8ZA 1E8GA 2GQTA 2VFUA 1QLTA 2PLIA 4PWCA 2VFRA 1DIQA 4PVJA 5G5HB 2QPMA 2EXRA 3AM9A 4PZFA 4HG0A 5FXFA 3FW7A 1JROA 2O3GA 2R2ZA 3S1DA 1HSKA 3S1CA 4PVEA 2W54A 3TSJA 1AHVA 3KJMA 3NVZB 1I19A 3SR6B 1FFUC 1DIIA 5HMRA 4EC3A 4OALA 2BVFA 3W8XA 1ZXIC 4PWBA 1AHUA 4ZOHB 3D2DA 1N61C 2I0KA 3TSHA 1VDVA 2WDWA 2Y3SA 3C0PA 3NVWB 4BCAA 1E8FA 5AWVA 4UD8A 5HQXA 4O95A 2E3TA 3ETRB 3VTEA 5L6GA 2BVHA 1AHZA 1V97A 1UXYA 2W3RA 2W3SA 1VAOA 2Q85A 5L6FA 3D2HA 1QLUA 2GQUA 1W1JA 4PVHA 1ZR6A 4PVKA 3RJAA 4MLAA 3D2JA 1N62C 2BVGA 2NQWA 5AE3A 2Y4GA 2R8DA 3PM9A 3DQ0A 3TX1A 1FFVC 5ADZA 3NVVB 3B9JB 1N60C 2YVSA 1W1QA 4BC7A 2UUVA 2Y3RA 5D79A 3AMZA 5G5GB 1E8HA 2AXRA 1FO4A 2P4PA 1E0YA 3BW7A 2VFSA 2Q4WA 1SB3B 3DEDA 1MBTA 3I99A 3FWAA 1FIQB 4XLOA 4DNSA 1F0XA 5FXDA 2W55A 3GSYA 5FXPA 1DZNA 1W1MA 1W1KA 3FW8A 1N5WC 3EUB3 1N63C 2VFVA 3POPA 1WVFA 3W8WA 1W1SA 3NVYB 5I1VA 5K8EA 2VFTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NRZ B;  1T3Q C;  4BBY A;  1W1R A;  2VAO A;  5AE2 A;  5I1W A;  2QKN A;  3PQB A;  5FXE A;  3RJ8 A;  3HSU A;  5AE1 A;  3AN1 A;  2Y08 A;  2MBR A;  3NS1 B;  4ML8 A;  4BC9 A;  3S1F A;  3S1E A;  3FW9 A;  2IPI A;  1W1O A;  4PYT A;  1WVE A;  4JB1 A;  1N5X A;  4JAY A;  5HHZ A;  1W1L A;  3JS8 A;  1MBB A;  1WYG A;  3W8Z A;  1E8G A;  2GQT A;  2VFU A;  1QLT A;  4PWC A;  2VFR A;  1DIQ A;  4PVJ A;  2QPM A;  2EXR A;  3AM9 A;  4PZF A;  5FXF A;  3FW7 A;  1JRO A;  3S1D A;  1HSK A;  3S1C A;  4PVE A;  2W54 A;  3TSJ A;  1AHV A;  3KJM A;  3NVZ B;  1I19 A;  3SR6 B;  1FFU C;  1DII A;  5HMR A;  4EC3 A;  4OAL A;  2BVF A;  3W8X A;  1ZXI C;  4PWB A;  1AHU A;  4ZOH B;  3D2D A;  1N61 C;  2I0K A;  3TSH A;  1VDV A;  2WDW A;  2Y3S A;  3C0P A;  4BCA A;  1E8F A;  5AWV A;  4UD8 A;  5HQX A;  4O95 A;  2E3T A;  3ETR B;  3VTE A;  5L6G A;  2BVH A;  1AHZ A;  1V97 A;  1UXY A;  2W3R A;  2W3S A;  1VAO A;  2Q85 A;  5L6F A;  3D2H A;  1QLU A;  2GQU A;  1W1J A;  4PVH A;  1ZR6 A;  4PVK A;  3RJA A;  4MLA A;  3D2J A;  1N62 C;  2BVG A;  5AE3 A;  2Y4G A;  3PM9 A;  3DQ0 A;  3TX1 A;  1FFV C;  5ADZ A;  3B9J B;  1N60 C;  1W1Q A;  4BC7 A;  2Y3R A;  5D79 A;  3AMZ A;  1E8H A;  2AXR A;  1FO4 A;  1E0Y A;  3BW7 A;  2VFS A;  2Q4W A;  1MBT A;  3I99 A;  3FWA A;  1FIQ B;  4XLO A;  4DNS A;  1F0X A;  5FXD A;  2W55 A;  3GSY A;  5FXP A;  1DZN A;  1W1M A;  1W1K A;  3FW8 A;  1N5W C;  3EUB 3;  1N63 C;  2VFV A;  3POP A;  1WVF A;  3W8W A;  1W1S A;  5I1V A;  5K8E A;  2VFT A; 
#chains in the Genus database with same CATH topology
 3NRZ B;  1T3Q C;  4BBY A;  1W1R A;  2VAO A;  5AE2 A;  5I1W A;  2QKN A;  2PLS A;  5FXE A;  3PQB A;  1JRP A;  1RM6 B;  3HSU A;  3RJ8 A;  3LAE A;  5AE1 A;  2P13 A;  2OAI A;  3AN1 A;  2Y08 A;  2MBR A;  3NS1 B;  4ML8 A;  3HRD C;  2UUU A;  4BC9 A;  3S1F A;  3S1E A;  3LLB A;  3FW9 A;  2IPI A;  1W1O A;  2P3H A;  4PYT A;  1WVE A;  4JB1 A;  1N5X A;  4JAY A;  2RK5 A;  5HHZ A;  1W1L A;  3JS8 A;  1MBB A;  1WYG A;  3W8Z A;  1E8G A;  2GQT A;  2VFU A;  1QLT A;  2PLI A;  4PWC A;  2VFR A;  1DIQ A;  4PVJ A;  5G5H B;  2QPM A;  2EXR A;  3AM9 A;  4PZF A;  4HG0 A;  5FXF A;  3FW7 A;  1JRO A;  2O3G A;  2R2Z A;  3S1D A;  1HSK A;  3S1C A;  4PVE A;  2W54 A;  3TSJ A;  1AHV A;  3KJM A;  3NVZ B;  1I19 A;  3SR6 B;  1FFU C;  1DII A;  5HMR A;  4EC3 A;  4OAL A;  2BVF A;  3W8X A;  1ZXI C;  4PWB A;  1AHU A;  4ZOH B;  3D2D A;  1N61 C;  2I0K A;  3TSH A;  1VDV A;  3NVW B;  2WDW A;  3C0P A;  2Y3S A;  4BCA A;  1E8F A;  5AWV A;  4UD8 A;  5HQX A;  4O95 A;  2E3T A;  3ETR B;  3VTE A;  5L6G A;  2BVH A;  1AHZ A;  1V97 A;  1UXY A;  2W3R A;  2W3S A;  1VAO A;  2Q85 A;  5L6F A;  3D2H A;  1QLU A;  2GQU A;  1W1J A;  4PVH A;  1ZR6 A;  4PVK A;  3RJA A;  4MLA A;  3D2J A;  1N62 C;  2BVG A;  2NQW A;  5AE3 A;  2Y4G A;  2R8D A;  3PM9 A;  3DQ0 A;  3TX1 A;  1FFV C;  3NVV B;  5ADZ A;  3EJB B;  3B9J B;  1N60 C;  2YVS A;  1W1Q A;  4BC7 A;  2UUV A;  2Y3R A;  5D79 A;  3AMZ A;  5G5G B;  1E8H A;  2AXR A;  1FO4 A;  2P4P A;  1E0Y A;  3BW7 A;  2VFS A;  2Q4W A;  1SB3 B;  3DED A;  1MBT A;  3I99 A;  3FWA A;  1FIQ B;  4XLO A;  4DNS A;  1F0X A;  5FXD A;  2W55 A;  3GSY A;  5FXP A;  1DZN A;  1W1M A;  1W1K A;  3FW8 A;  1N5W C;  3EUB 3;  1N63 C;  3EJE B;  3EJD B;  2VFV A;  3POP A;  1WVF A;  3W8W A;  1W1S A;  3NVY B;  5I1V A;  5K8E A;  2VFT A; 
#chains in the Genus database with same CATH homology
 3NRZ B;  1T3Q C;  4BBY A;  1W1R A;  2VAO A;  5AE2 A;  5I1W A;  2QKN A;  2PLS A;  5FXE A;  3PQB A;  1JRP A;  1RM6 B;  3HSU A;  3RJ8 A;  3LAE A;  5AE1 A;  2P13 A;  2OAI A;  3AN1 A;  2Y08 A;  2MBR A;  3NS1 B;  4ML8 A;  3HRD C;  2UUU A;  4BC9 A;  3S1F A;  3S1E A;  3LLB A;  3FW9 A;  2IPI A;  1W1O A;  2P3H A;  4PYT A;  1WVE A;  4JB1 A;  1N5X A;  4JAY A;  2RK5 A;  5HHZ A;  1W1L A;  3JS8 A;  1MBB A;  1WYG A;  3W8Z A;  1E8G A;  2GQT A;  2VFU A;  1QLT A;  2PLI A;  4PWC A;  2VFR A;  1DIQ A;  4PVJ A;  5G5H B;  2QPM A;  2EXR A;  3AM9 A;  4PZF A;  4HG0 A;  5FXF A;  3FW7 A;  1JRO A;  2O3G A;  2R2Z A;  3S1D A;  1HSK A;  3S1C A;  4PVE A;  2W54 A;  3TSJ A;  1AHV A;  3KJM A;  3NVZ B;  1I19 A;  3SR6 B;  1FFU C;  1DII A;  5HMR A;  4EC3 A;  4OAL A;  2BVF A;  3W8X A;  1ZXI C;  4PWB A;  1AHU A;  4ZOH B;  3D2D A;  1N61 C;  2I0K A;  3TSH A;  1VDV A;  2WDW A;  2Y3S A;  3C0P A;  3NVW B;  4BCA A;  1E8F A;  5AWV A;  4UD8 A;  5HQX A;  4O95 A;  2E3T A;  3ETR B;  3VTE A;  5L6G A;  2BVH A;  1AHZ A;  1V97 A;  1UXY A;  2W3R A;  2W3S A;  1VAO A;  2Q85 A;  5L6F A;  3D2H A;  1QLU A;  2GQU A;  1W1J A;  4PVH A;  1ZR6 A;  4PVK A;  3RJA A;  4MLA A;  3D2J A;  1N62 C;  2BVG A;  2NQW A;  5AE3 A;  2Y4G A;  2R8D A;  3PM9 A;  3DQ0 A;  3TX1 A;  1FFV C;  5ADZ A;  3NVV B;  3B9J B;  1N60 C;  2YVS A;  1W1Q A;  4BC7 A;  2UUV A;  2Y3R A;  5D79 A;  3AMZ A;  5G5G B;  1E8H A;  2AXR A;  1FO4 A;  2P4P A;  1E0Y A;  3BW7 A;  2VFS A;  2Q4W A;  1SB3 B;  3DED A;  1MBT A;  3I99 A;  3FWA A;  1FIQ B;  4XLO A;  4DNS A;  1F0X A;  5FXD A;  2W55 A;  3GSY A;  5FXP A;  1DZN A;  1W1M A;  1W1K A;  3FW8 A;  1N5W C;  3EUB 3;  1N63 C;  2VFV A;  3POP A;  1WVF A;  3W8W A;  1W1S A;  3NVY B;  5I1V A;  5K8E A;  2VFT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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