3D7VA

Crystal structure of mcl-1 in complex with an mcl-1 selective bh3 ligand
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
151
structure length
144
Chain Sequence
DDLYRQSLEIISRYLREQATGSKDGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Apoptosis
molecule keywords Induced myeloid leukemia cell differentiation protein Mcl-1
publication title A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
pubmed doi rcsb
source organism Mus musculus
total genus 56
structure length 144
sequence length 151
ec nomenclature
pdb deposition date 2008-05-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.437.10 Mainly Alpha Orthogonal Bundle Apoptosis Regulator Bcl-x Blc2-like 3d7vA01
1LXLA 2A5YA 4U2UA 1F16A 1DDBA 4ZEQA 3CVAX 1G5MA 4OQ6A 4OQ5A 5KU9A 5FDRA 4BPJA 2WH6A 4BD8A 1O0LA 3IHCA 2V6QA 2XA0A 3KJ2A 3WIYA 2BIDA 4ZIIA 2RODA 4QVXA 4BPIA 5C6HA 3QBRA 4OYDA 4S0PA 3MQPA 1MK3A 3D7VA 4BD2A 4BD6A 2O2MA 2XPXA 2KBWA 3KJ1A 5IF4A 1WSXA 3DVUA 2O2FA 4ZIFA 2ME8A 4YK9A 1R2DA 1BXLA 1PQ0A 1OHUA 2VOHA 3IO9A 4MI8A 4BDUA 4BD7A 3ILCA 2NLAA 5JSBA 5FC4A 5FMIA 2M5BA 2B48A 4QNQA 2LR1A 2IMSA 1R2GA 2ABOA 1YSGA 3PK1A 4ZIEA 1ZY3A 4ZIHA 1R2EA 2NL9A 4S0OA 3KJ0A 2W3LA 3MK8A 1AF3A 5FDOA 1R2HA 1YSWA 2VOGA 3IHEA 4ZBIA 5KTGA 1TY4A 2O22A 1MAZA 4WMRA 1PQ1A 2KUAA 4HW2A 2VM6A 4U2VA 5C3FA 2IMTA 2JM6B 2K7WA 3I1HA 3KZ0A 3BL2A 1YSIA 3WIXA 2PQKA 3IHDA 3IIGA 1R2IA 2MHSA 4YJ4A 1YSNA 4B4SA 1K3KA 1Q59A 4HW3A 2VOIA 5IEZA 2ROCA 4G35A 2O21A 3IIHA 1GJHA 2YV6A 1G5JA 4ZIGA 2JCNA 2MEJA 2O2NA 2VOFA 4ZBFA 2BZWA 4HW4A 4K5BC
chains in the Genus database with same CATH superfamily
1LXLA 2A5YA 4U2UA 1F16A 1DDBA 4ZEQA 2VVYA 2JBYA 1G5MA 3CVAX 4OQ6A 4OQ5A 5KU9A 4UF2A 5FDRA 4BPJA 2WH6A 4BD8A 1O0LA 2I39A 2VVWA 3IHCA 4D2LA 2V6QA 2XA0A 3KJ2A 3WIYA 2BIDA 4ZIIA 4D2MA 2RODA 4QVXA 4BPIA 5C6HA 3QBRA 4OYDA 4BBDA 4LQKA 4S0PA 3MQPA 1MK3A 2K36A 3D7VA 4BD2A 4BD6A 2O2MA 2XPXA 2KBWA 3KJ1A 5IF4A 1WSXA 2UXEA 3DVUA 2O2FA 2VVXA 4ZIFA 2ME8A 4YK9A 1R2DA 1BXLA 1PQ0A 1OHUA 2VOHA 3IO9A 4MI8A 4BDUA 4BD7A 3ILCA 2NLAA 5JSBA 5FC4A 5FMIA 2M5BA 4UF1A 4BBBA 2B48A 4QNQA 2LR1A 2IMSA 1R2GA 2ABOA 1YSGA 3PK1A 4ZIEA 1ZY3A 4UF3A 4ZIHA 4BBCA 1R2EA 2NL9A 4S0OA 3KJ0A 2W3LA 3JRVA 3MK8A 1AF3A 5FDOA 1R2HA 1YSWA 2VOGA 3IHEA 4ZBIA 5KTGA 1TY4A 2JBXA 2VTYA 2O22A 1MAZA 4WMRA 1PQ1A 2KUAA 2O42A 2VM6A 4U2VA 4HW2A 2IMTA 5C3FA 2JM6B 2K7WA 3I1HA 3KZ0A 3BL2A 1YSIA 3WIXA 2PQKA 3IHDA 3IIGA 4M0SA 1R2IA 2MHSA 4YJ4A 1YSNA 4B4SA 1K3KA 1Q59A 4HW3A 2VOIA 5IEZA 2ROCA 4G35A 2O21A 3IIHA 1GJHA 2YV6A 1G5JA 4ZIGA 2JCNA 2MEJA 2O2NA 2VOFA 4ZBFA 2BZWA 4HW4A 4K5BC
chains in the Genus database with same CATH topology
1LXLA 2A5YA 4U2UA 1F16A 1DDBA 4ZEQA 3CVAX 1G5MA 4OQ6A 4OQ5A 5KU9A 5FDRA 4BPJA 2WH6A 4BD8A 1O0LA 3IHCA 2V6QA 2XA0A 3KJ2A 3WIYA 2BIDA 4ZIIA 2RODA 4QVXA 4BPIA 5C6HA 3QBRA 4OYDA 4S0PA 3MQPA 1MK3A 3D7VA 4BD2A 4BD6A 2O2MA 2XPXA 2KBWA 3KJ1A 5IF4A 1WSXA 3DVUA 2O2FA 4ZIFA 2ME8A 4YK9A 1R2DA 1BXLA 1PQ0A 1OHUA 2VOHA 3IO9A 4MI8A 4BDUA 4BD7A 3ILCA 2NLAA 5JSBA 5FC4A 5FMIA 2M5BA 2B48A 4QNQA 2LR1A 2IMSA 1R2GA 2ABOA 1YSGA 3PK1A 4ZIEA 1ZY3A 4ZIHA 1R2EA 2NL9A 4S0OA 3KJ0A 2W3LA 3MK8A 1AF3A 5FDOA 1R2HA 1YSWA 2VOGA 3IHEA 4ZBIA 5KTGA 1TY4A 2O22A 1MAZA 4WMRA 1PQ1A 2KUAA 4HW2A 2VM6A 4U2VA 5C3FA 2IMTA 2JM6B 2K7WA 3I1HA 3KZ0A 3BL2A 1YSIA 3WIXA 2PQKA 3IHDA 3IIGA 1R2IA 2MHSA 4YJ4A 1YSNA 4B4SA 1K3KA 1Q59A 4HW3A 2VOIA 5IEZA 2ROCA 4G35A 2O21A 3IIHA 1GJHA 2YV6A 1G5JA 4ZIGA 2JCNA 2MEJA 2O2NA 2VOFA 4ZBFA 2BZWA 4HW4A 4K5BC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LXL A;  2A5Y A;  4U2U A;  1F16 A;  1DDB A;  4ZEQ A;  3CVA X;  1G5M A;  4OQ6 A;  4OQ5 A;  5KU9 A;  5FDR A;  4BPJ A;  2WH6 A;  4BD8 A;  1O0L A;  3IHC A;  2V6Q A;  2XA0 A;  3KJ2 A;  3WIY A;  2BID A;  4ZII A;  2ROD A;  4QVX A;  4BPI A;  5C6H A;  3QBR A;  4OYD A;  4S0P A;  3MQP A;  1MK3 A;  3D7V A;  4BD2 A;  4BD6 A;  2O2M A;  2XPX A;  2KBW A;  3KJ1 A;  5IF4 A;  1WSX A;  3DVU A;  2O2F A;  4ZIF A;  2ME8 A;  4YK9 A;  1R2D A;  1BXL A;  1PQ0 A;  1OHU A;  2VOH A;  3IO9 A;  4MI8 A;  4BDU A;  4BD7 A;  3ILC A;  2NLA A;  5JSB A;  5FC4 A;  5FMI A;  2M5B A;  2B48 A;  4QNQ A;  2LR1 A;  2IMS A;  1R2G A;  2ABO A;  1YSG A;  3PK1 A;  4ZIE A;  1ZY3 A;  4ZIH A;  1R2E A;  2NL9 A;  4S0O A;  3KJ0 A;  2W3L A;  3MK8 A;  1AF3 A;  5FDO A;  1R2H A;  1YSW A;  2VOG A;  3IHE A;  4ZBI A;  5KTG A;  1TY4 A;  2O22 A;  1MAZ A;  4WMR A;  1PQ1 A;  2KUA A;  4HW2 A;  2VM6 A;  4U2V A;  5C3F A;  2IMT A;  2JM6 B;  2K7W A;  3I1H A;  3KZ0 A;  3BL2 A;  1YSI A;  3WIX A;  2PQK A;  3IHD A;  3IIG A;  1R2I A;  2MHS A;  4YJ4 A;  1YSN A;  4B4S A;  1K3K A;  1Q59 A;  4HW3 A;  2VOI A;  5IEZ A;  2ROC A;  4G35 A;  2O21 A;  3IIH A;  1GJH A;  2YV6 A;  1G5J A;  4ZIG A;  2JCN A;  2MEJ A;  2O2N A;  2VOF A;  4ZBF A;  2BZW A;  4HW4 A;  4K5B C; 
#chains in the Genus database with same CATH topology
 1LXL A;  2A5Y A;  4U2U A;  1F16 A;  1DDB A;  4ZEQ A;  2VVY A;  2JBY A;  1G5M A;  3CVA X;  4OQ6 A;  4OQ5 A;  5KU9 A;  4UF2 A;  5FDR A;  4BPJ A;  2WH6 A;  4BD8 A;  1O0L A;  2I39 A;  2VVW A;  3IHC A;  4D2L A;  2V6Q A;  2XA0 A;  3KJ2 A;  3WIY A;  2BID A;  4ZII A;  4D2M A;  2ROD A;  4QVX A;  4BPI A;  5C6H A;  3QBR A;  4OYD A;  4BBD A;  4LQK A;  4S0P A;  3MQP A;  1MK3 A;  2K36 A;  3D7V A;  4BD2 A;  4BD6 A;  2O2M A;  2XPX A;  2KBW A;  3KJ1 A;  5IF4 A;  1WSX A;  2UXE A;  3DVU A;  2O2F A;  2VVX A;  4ZIF A;  2ME8 A;  4YK9 A;  1R2D A;  1BXL A;  1PQ0 A;  1OHU A;  2VOH A;  3IO9 A;  4MI8 A;  4BDU A;  4BD7 A;  3ILC A;  2NLA A;  5JSB A;  5FC4 A;  5FMI A;  2M5B A;  4UF1 A;  4BBB A;  2B48 A;  4QNQ A;  2LR1 A;  2IMS A;  1R2G A;  2ABO A;  1YSG A;  3PK1 A;  4ZIE A;  1ZY3 A;  4UF3 A;  4ZIH A;  4BBC A;  1R2E A;  2NL9 A;  4S0O A;  3KJ0 A;  2W3L A;  3JRV A;  3MK8 A;  1AF3 A;  5FDO A;  1R2H A;  1YSW A;  2VOG A;  3IHE A;  4ZBI A;  5KTG A;  1TY4 A;  2JBX A;  2VTY A;  2O22 A;  1MAZ A;  4WMR A;  1PQ1 A;  2KUA A;  2O42 A;  2VM6 A;  4U2V A;  4HW2 A;  2IMT A;  5C3F A;  2JM6 B;  2K7W A;  3I1H A;  3KZ0 A;  3BL2 A;  1YSI A;  3WIX A;  2PQK A;  3IHD A;  3IIG A;  4M0S A;  1R2I A;  2MHS A;  4YJ4 A;  1YSN A;  4B4S A;  1K3K A;  1Q59 A;  4HW3 A;  2VOI A;  5IEZ A;  2ROC A;  4G35 A;  2O21 A;  3IIH A;  1GJH A;  2YV6 A;  1G5J A;  4ZIG A;  2JCN A;  2MEJ A;  2O2N A;  2VOF A;  4ZBF A;  2BZW A;  4HW4 A;  4K5B C; 
#chains in the Genus database with same CATH homology
 1LXL A;  2A5Y A;  4U2U A;  1F16 A;  1DDB A;  4ZEQ A;  3CVA X;  1G5M A;  4OQ6 A;  4OQ5 A;  5KU9 A;  5FDR A;  4BPJ A;  2WH6 A;  4BD8 A;  1O0L A;  3IHC A;  2V6Q A;  2XA0 A;  3KJ2 A;  3WIY A;  2BID A;  4ZII A;  2ROD A;  4QVX A;  4BPI A;  5C6H A;  3QBR A;  4OYD A;  4S0P A;  3MQP A;  1MK3 A;  3D7V A;  4BD2 A;  4BD6 A;  2O2M A;  2XPX A;  2KBW A;  3KJ1 A;  5IF4 A;  1WSX A;  3DVU A;  2O2F A;  4ZIF A;  2ME8 A;  4YK9 A;  1R2D A;  1BXL A;  1PQ0 A;  1OHU A;  2VOH A;  3IO9 A;  4MI8 A;  4BDU A;  4BD7 A;  3ILC A;  2NLA A;  5JSB A;  5FC4 A;  5FMI A;  2M5B A;  2B48 A;  4QNQ A;  2LR1 A;  2IMS A;  1R2G A;  2ABO A;  1YSG A;  3PK1 A;  4ZIE A;  1ZY3 A;  4ZIH A;  1R2E A;  2NL9 A;  4S0O A;  3KJ0 A;  2W3L A;  3MK8 A;  1AF3 A;  5FDO A;  1R2H A;  1YSW A;  2VOG A;  3IHE A;  4ZBI A;  5KTG A;  1TY4 A;  2O22 A;  1MAZ A;  4WMR A;  1PQ1 A;  2KUA A;  4HW2 A;  2VM6 A;  4U2V A;  5C3F A;  2IMT A;  2JM6 B;  2K7W A;  3I1H A;  3KZ0 A;  3BL2 A;  1YSI A;  3WIX A;  2PQK A;  3IHD A;  3IIG A;  1R2I A;  2MHS A;  4YJ4 A;  1YSN A;  4B4S A;  1K3K A;  1Q59 A;  4HW3 A;  2VOI A;  5IEZ A;  2ROC A;  4G35 A;  2O21 A;  3IIH A;  1GJH A;  2YV6 A;  1G5J A;  4ZIG A;  2JCN A;  2MEJ A;  2O2N A;  2VOF A;  4ZBF A;  2BZW A;  4HW4 A;  4K5B C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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