3DZ3A

Human adometdc f223a mutant with covalently bound s-adenosylmethionine methyl ester
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
260
structure length
244
Chain Sequence
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPEQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMANPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQQKIEGFKRLDCQSAMFNDYNFVFTSFAKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-adenosylmethionine decarboxylase beta chain
total genus 56
structure length 244
sequence length 260
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2008-07-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 3dz3A00
3DZ3A 1TLUA 5TVOA 1TMIA 3DZ2A 3EP9A 3H0WA 2IIIA 1I72A 3DZ4A 3EP7A 3EP3A 1I7MA 1JENA 1I7BA 1MHMA 3EPAA 3EP5A 3EP6A 3EPBA 3DZ5A 3EP4A 1MSVA 1I7CA 3EP8A 3DZ7A 1I79A 3H0VA 1JL0A 1VR7A 3DZ6A
chains in the Genus database with same CATH superfamily
3DZ3A 1TLUA 5TVOA 1TMIA 3DZ2A 3EP9A 3H0WA 2IIIA 1I72A 3DZ4A 3EP7A 3EP3A 1I7MA 1JENA 1I7BA 1MHMA 3EPAA 3EP5A 3EP6A 3EPBA 3DZ5A 3EP4A 1MSVA 1I7CA 3EP8A 3DZ7A 1I79A 3H0VA 1JL0A 1VR7A 3DZ6A
chains in the Genus database with same CATH topology
3DZ3A 1I79B 1TLUA 3H0VB 3DZ7B 5TVOA 1TMIA 3DZ2A 3EP9A 3H0WA 3DZ6B 2IIIA 3DZ3B 1I72A 3DZ4A 3EP7A 5TVOB 3EP3A 1I7MA 3DZ2B 1JENA 3EP4B 3EP9B 1I7BA 1MHMA 3EPAA 3EP5A 3EP6A 3EPBA 3H0WB 3DZ5A 1I72B 3EP4A 1MSVA 1I7CA 3EP8A 3EP7B 3EP3B 1I7MB 1I79A 1JENB 3DZ7A 3DZ4B 3H0VA 1I7BB 1MHMB 1JL0A 1VR7A 3EPBB 3EPAB 3EP5B 3DZ5B 3EP6B 1I7CB 3DZ6A 3EP8B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DZ3 A;  1TLU A;  5TVO A;  1TMI A;  3DZ2 A;  3EP9 A;  3H0W A;  2III A;  1I72 A;  3DZ4 A;  3EP7 A;  3EP3 A;  1I7M A;  1JEN A;  1I7B A;  1MHM A;  3EPA A;  3EP5 A;  3EP6 A;  3EPB A;  3DZ5 A;  3EP4 A;  1MSV A;  1I7C A;  3EP8 A;  3DZ7 A;  1I79 A;  3H0V A;  1JL0 A;  1VR7 A;  3DZ6 A; 
#chains in the Genus database with same CATH topology
 3DZ3 A;  1TLU A;  5TVO A;  1TMI A;  3DZ2 A;  3EP9 A;  3H0W A;  2III A;  1I72 A;  3DZ4 A;  3EP7 A;  3EP3 A;  1I7M A;  1JEN A;  1I7B A;  1MHM A;  3EPA A;  3EP5 A;  3EP6 A;  3EPB A;  3DZ5 A;  3EP4 A;  1MSV A;  1I7C A;  3EP8 A;  3DZ7 A;  1I79 A;  3H0V A;  1JL0 A;  1VR7 A;  3DZ6 A; 
#chains in the Genus database with same CATH homology
 3DZ3 A;  1I79 B;  1TLU A;  3H0V B;  3DZ7 B;  5TVO A;  1TMI A;  3DZ2 A;  3EP9 A;  3H0W A;  3DZ6 B;  2III A;  3DZ3 B;  1I72 A;  3DZ4 A;  3EP7 A;  5TVO B;  3EP3 A;  1I7M A;  3DZ2 B;  1JEN A;  3EP4 B;  3EP9 B;  1I7B A;  1MHM A;  3EPA A;  3EP5 A;  3EP6 A;  3EPB A;  3H0W B;  3DZ5 A;  1I72 B;  3EP4 A;  1MSV A;  1I7C A;  3EP8 A;  3EP7 B;  3EP3 B;  1I7M B;  1I79 A;  1JEN B;  3DZ7 A;  3DZ4 B;  3H0V A;  1I7B B;  1MHM B;  1JL0 A;  1VR7 A;  3EPB B;  3EPA B;  3EP5 B;  3DZ5 B;  3EP6 B;  1I7C B;  3DZ6 A;  3EP8 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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