3DZ5A

Human adometdc with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
260
structure length
244
Chain Sequence
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDSQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSQKIEGFKRLDCQSAMFNDYNFVFTSFAKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
pubmed doi rcsb
molecule tags Lyase
source organism Homo sapiens
molecule keywords S-adenosylmethionine decarboxylase beta chain
total genus 65
structure length 244
sequence length 260
ec nomenclature ec 4.1.1.50: Adenosylmethionine decarboxylase.
pdb deposition date 2008-07-29
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.90.10 Alpha Beta 4-Layer Sandwich S-adenosylmethionine decarboxylase S-adenosylmethionine decarboxylase 3dz5A00
1I72A 3EP5A 1JL0A 3EP7A 1MHMA 3EP9A 3EP4A 2IIIA 1MSVA 1I7BA 5TVOA 1I79A 1I7CA 3EP3A 3DZ2A 3EPAA 1TMIA 3EP6A 3DZ7A 3EPBA 1JENA 1TLUA 1VR7A 3DZ6A 3H0WA 3DZ4A 3EP8A 3DZ5A 1I7MA 3DZ3A 3H0VA
chains in the Genus database with same CATH superfamily
1I72A 3EP5A 1JL0A 3EP7A 1MHMA 3EP9A 3EP4A 2IIIA 1MSVA 1I7BA 5TVOA 1I79A 1I7CA 3EP3A 3DZ2A 3EPAA 1TMIA 3EP6A 3DZ7A 3EPBA 1JENA 1TLUA 1VR7A 3DZ6A 3H0WA 3DZ4A 3EP8A 3DZ5A 1I7MA 3DZ3A 3H0VA
chains in the Genus database with same CATH topology
1I72A 3EP5A 3EPAB 1JL0A 3EP7A 1MHMA 3EP6B 3EP9A 3EP4A 2IIIA 1MSVA 1I7BA 3DZ7B 1JENB 3EPBB 5TVOA 3DZ6B 1I7CA 1I79A 3H0WB 3EP3A 3DZ4B 3DZ2A 3EP8B 3DZ5B 3EPAA 1I7MB 3DZ3B 3H0VB 1TMIA 3EP6A 1I72B 3DZ7A 3EPBA 1JENA 1TLUA 1VR7A 3EP5B 3DZ6A 3EP7B 1MHMB 3EP4B 3H0WA 3EP9B 3DZ4A 1I7BB 3EP8A 3DZ5A 5TVOB 1I7CB 1I79B 1I7MA 3DZ3A 3H0VA 3EP3B 3DZ2B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I72 A;  3EP5 A;  1JL0 A;  3EP7 A;  1MHM A;  3EP9 A;  3EP4 A;  2III A;  1MSV A;  1I7B A;  5TVO A;  1I79 A;  1I7C A;  3EP3 A;  3DZ2 A;  3EPA A;  1TMI A;  3EP6 A;  3DZ7 A;  3EPB A;  1JEN A;  1TLU A;  1VR7 A;  3DZ6 A;  3H0W A;  3DZ4 A;  3EP8 A;  3DZ5 A;  1I7M A;  3DZ3 A;  3H0V A; 
#chains in the Genus database with same CATH topology
 1I72 A;  3EP5 A;  1JL0 A;  3EP7 A;  1MHM A;  3EP9 A;  3EP4 A;  2III A;  1MSV A;  1I7B A;  5TVO A;  1I79 A;  1I7C A;  3EP3 A;  3DZ2 A;  3EPA A;  1TMI A;  3EP6 A;  3DZ7 A;  3EPB A;  1JEN A;  1TLU A;  1VR7 A;  3DZ6 A;  3H0W A;  3DZ4 A;  3EP8 A;  3DZ5 A;  1I7M A;  3DZ3 A;  3H0V A; 
#chains in the Genus database with same CATH homology
 1I72 A;  3EP5 A;  3EPA B;  1JL0 A;  3EP7 A;  1MHM A;  3EP6 B;  3EP9 A;  3EP4 A;  2III A;  1MSV A;  1I7B A;  3DZ7 B;  1JEN B;  3EPB B;  5TVO A;  3DZ6 B;  1I7C A;  1I79 A;  3H0W B;  3EP3 A;  3DZ4 B;  3DZ2 A;  3EP8 B;  3DZ5 B;  3EPA A;  1I7M B;  3DZ3 B;  3H0V B;  1TMI A;  3EP6 A;  1I72 B;  3DZ7 A;  3EPB A;  1JEN A;  1TLU A;  1VR7 A;  3EP5 B;  3DZ6 A;  3EP7 B;  1MHM B;  3EP4 B;  3H0W A;  3EP9 B;  3DZ4 A;  1I7B B;  3EP8 A;  3DZ5 A;  5TVO B;  1I7C B;  1I79 B;  1I7M A;  3DZ3 A;  3H0V A;  3EP3 B;  3DZ2 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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