3E04A

Crystal structure of human fumarate hydratase
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
461
structure length
456
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase
publication title Crystal structure of human fumarate hydratase
rcsb
source organism Homo sapiens
molecule tags Lyase
total genus 175
structure length 456
sequence length 461
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2008-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3e04A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3e04A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3e04A02
1FUQA 1FURA 2QVEA 3OCEA 2QGAB 4NSLA 1AUWA 2NYNA 1KQ7A 1U16A 3C8TA 2PFMA 2O6YA 3RRPA 2PTRA 1I0AA 1C3CA 4ADMA 2NYFA 3UNVA 4NLEA 1Y2MA 3OCFA 1W27A 1T6PA 4MX2A 3QBPA 3BHGA 2J91A 4C5SA 4CQ5A 1C3UA 4APBA 1J3UA 1T6JA 2O7FA 3R6VA 1YISA 1GK3A 1YFMA 3KDYA 1RE5A 2RJRA 3R6QA 4HGVA 1JSWA 2E9FA 1DOFA 3TV2A 4C5UA 4EEIA 1HY0A 4V2QA 1YFEA 4BAAA 4APAA 2RJSA 1GKJA 4FLCA 2O7EA 1VDKA 4EFCA 4C5RA 1HY1A 1DCNA 4FFXA 5D6BA 3E04A 1GK2A 1XWOA 2PTQA 5EYTA 2PTSA 1TJWA 1B8FA 2O78A 3RD8A 4C6GA 3NO9A 1Q5NA 1EB4A 4ADLA 2X75A 1K62A 2VD6A 3CZOA 1TJVA 5F91A 2O7DA 5F92A 1TJUA 3KDZA 3R6YA 2HVGA 5HW2A 3GTDA 1U15A 1TJ7A 4V2RA 2OHYA 2FUSA 3GZHA 2YIIA 4BABA 1GKMA 1K7WA 5EYVA 1FUPA 1FUOA 3NZ4A 2O7BA
chains in the Genus database with same CATH superfamily
4YIKA 1FUQA 1FURA 2QVEA 3OCEA 2QGAB 4NSLA 5M0JA 2JAOA 2VL7A 1AUWA 2NYNA 1Z4PX 1KQ7A 1U16A 3C8TA 2PFMA 4E88A 2O6YA 4A15A 3RRPA 2JAWA 2PTRA 1I0AA 1C3CA 4ADMA 2NYFA 3UNVA 4L6CA 1Z4MA 2JAUA 2VSFA 4NLEA 1Z4QA 1Y2MA 3OCFA 4NFLA 1W27A 1T6PA 1Z4KA 4MX2A 2D28C 3F4TA 3F4SA 1XMCA 3QBPA 1T9HA 3BHGA 2J91A 4C5SA 4CQ5A 1C3UA 4APBA 1IW7D 3CRVA 1J3UA 1T6JA 3F4RA 2O7FA 3R6VA 1YISA 1GK3A 1YFMA 3KDYA 1RE5A 4YIHA 3BWVA 2RJRA 3R6QA 4HGVA 2I7DA 1Z4JA 1JSWA 2E9FA 1DOFA 4MUMA 3TV2A 4C5UA 4EEIA 1HY0A 4V2QA 1YFEA 1Z4IA 4BAAA 4APAA 2RJSA 1GKJA 4FLCA 2O7EA 1VDKA 4EFCA 1XLYA 3U19A 4C5RA 1XMDA 1HY1A 1DCNA 4FFXA 5D6BA 3E04A 2FENA 1GK2A 1XWOA 2PTQA 4MWOA 5EYTA 5M0IA 2PTSA 2FELA 1TJWA 1B8FA 1Q92A 1XL7A 2O78A 3CRW1 4L57A 3RD8A 4C6GA 5H8WA 3NO9A 1Q5NA 1EB4A 4ADLA 2X75A 1K62A 2VD6A 1Z4LA 3CZOA 1TJVA 1Q91A 2RCNA 5F91A 1U0LA 2D27A 2O7DA 1XL8A 5F92A 1TJUA 3KDZA 3R6YA 2HVGA 4WNLA 5HW2A 3GTDA 1U15A 2YV5A 1TJ7A 4V2RA 4L6AA 4IQJM 2OHYA 2FUSA 3GZHA 2YIIA 4BABA 1GKMA 1K7WA 2JARA 1MH9A 5EYVA 1FUPA 3CI0K 3U13A 1FUOA 3NZ4A 2O7BA
chains in the Genus database with same CATH topology
1FUQA 1FURA 2QVEA 3OCEA 2QGAB 4NSLA 1AUWA 2NYNA 1KQ7A 1U16A 3C8TA 2PFMA 2O6YA 3RRPA 2PTRA 1I0AA 1C3CA 4ADMA 2NYFA 3UNVA 4NLEA 1Y2MA 3OCFA 1W27A 1T6PA 4MX2A 3QBPA 3BHGA 2J91A 4C5SA 4CQ5A 1C3UA 4APBA 1J3UA 1T6JA 2O7FA 3R6VA 1YISA 1GK3A 1YFMA 3KDYA 1RE5A 2RJRA 3R6QA 4HGVA 1JSWA 2E9FA 1DOFA 3TV2A 4C5UA 4EEIA 1HY0A 4V2QA 1YFEA 4BAAA 4APAA 2RJSA 1GKJA 4FLCA 2O7EA 1VDKA 4EFCA 4C5RA 1HY1A 1DCNA 4FFXA 5D6BA 3E04A 1GK2A 1XWOA 2PTQA 5EYTA 2PTSA 1TJWA 1B8FA 2O78A 3RD8A 4C6GA 3NO9A 1Q5NA 1EB4A 4ADLA 2X75A 1K62A 2VD6A 3CZOA 1TJVA 5F91A 2O7DA 5F92A 1TJUA 3KDZA 3R6YA 2HVGA 5HW2A 3GTDA 1U15A 1TJ7A 4V2RA 2OHYA 2FUSA 3GZHA 2YIIA 4BABA 1GKMA 1K7WA 5EYVA 1FUPA 1FUOA 3NZ4A 2O7BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUQ A;  1FUR A;  2QVE A;  3OCE A;  2QGA B;  4NSL A;  1AUW A;  2NYN A;  1KQ7 A;  1U16 A;  3C8T A;  2PFM A;  2O6Y A;  3RRP A;  2PTR A;  1I0A A;  1C3C A;  4ADM A;  2NYF A;  3UNV A;  4NLE A;  1Y2M A;  3OCF A;  1W27 A;  1T6P A;  4MX2 A;  3QBP A;  3BHG A;  2J91 A;  4C5S A;  4CQ5 A;  1C3U A;  4APB A;  1J3U A;  1T6J A;  2O7F A;  3R6V A;  1YIS A;  1GK3 A;  1YFM A;  3KDY A;  1RE5 A;  2RJR A;  3R6Q A;  4HGV A;  1JSW A;  2E9F A;  1DOF A;  3TV2 A;  4C5U A;  4EEI A;  1HY0 A;  4V2Q A;  1YFE A;  4BAA A;  4APA A;  2RJS A;  1GKJ A;  4FLC A;  2O7E A;  1VDK A;  4EFC A;  4C5R A;  1HY1 A;  1DCN A;  4FFX A;  5D6B A;  3E04 A;  1GK2 A;  1XWO A;  2PTQ A;  5EYT A;  2PTS A;  1TJW A;  1B8F A;  2O78 A;  3RD8 A;  4C6G A;  3NO9 A;  1Q5N A;  1EB4 A;  4ADL A;  2X75 A;  1K62 A;  2VD6 A;  3CZO A;  1TJV A;  5F91 A;  2O7D A;  5F92 A;  1TJU A;  3KDZ A;  3R6Y A;  2HVG A;  5HW2 A;  3GTD A;  1U15 A;  1TJ7 A;  4V2R A;  2OHY A;  2FUS A;  3GZH A;  2YII A;  4BAB A;  1GKM A;  1K7W A;  5EYV A;  1FUP A;  1FUO A;  3NZ4 A;  2O7B A; 
#chains in the Genus database with same CATH topology
 4YIK A;  1FUQ A;  1FUR A;  2QVE A;  3OCE A;  2QGA B;  4NSL A;  5M0J A;  2JAO A;  2VL7 A;  1AUW A;  2NYN A;  1Z4P X;  1KQ7 A;  1U16 A;  3C8T A;  2PFM A;  4E88 A;  2O6Y A;  4A15 A;  3RRP A;  2JAW A;  2PTR A;  1I0A A;  1C3C A;  4ADM A;  2NYF A;  3UNV A;  4L6C A;  1Z4M A;  2JAU A;  2VSF A;  4NLE A;  1Z4Q A;  1Y2M A;  3OCF A;  4NFL A;  1W27 A;  1T6P A;  1Z4K A;  4MX2 A;  2D28 C;  3F4T A;  3F4S A;  1XMC A;  3QBP A;  1T9H A;  3BHG A;  2J91 A;  4C5S A;  4CQ5 A;  1C3U A;  4APB A;  1IW7 D;  3CRV A;  1J3U A;  1T6J A;  3F4R A;  2O7F A;  3R6V A;  1YIS A;  1GK3 A;  1YFM A;  3KDY A;  1RE5 A;  4YIH A;  3BWV A;  2RJR A;  3R6Q A;  4HGV A;  2I7D A;  1Z4J A;  1JSW A;  2E9F A;  1DOF A;  4MUM A;  3TV2 A;  4C5U A;  4EEI A;  1HY0 A;  4V2Q A;  1YFE A;  1Z4I A;  4BAA A;  4APA A;  2RJS A;  1GKJ A;  4FLC A;  2O7E A;  1VDK A;  4EFC A;  1XLY A;  3U19 A;  4C5R A;  1XMD A;  1HY1 A;  1DCN A;  4FFX A;  5D6B A;  3E04 A;  2FEN A;  1GK2 A;  1XWO A;  2PTQ A;  4MWO A;  5EYT A;  5M0I A;  2PTS A;  2FEL A;  1TJW A;  1B8F A;  1Q92 A;  1XL7 A;  2O78 A;  3CRW 1;  4L57 A;  3RD8 A;  4C6G A;  5H8W A;  3NO9 A;  1Q5N A;  1EB4 A;  4ADL A;  2X75 A;  1K62 A;  2VD6 A;  1Z4L A;  3CZO A;  1TJV A;  1Q91 A;  2RCN A;  5F91 A;  1U0L A;  2D27 A;  2O7D A;  1XL8 A;  5F92 A;  1TJU A;  3KDZ A;  3R6Y A;  2HVG A;  4WNL A;  5HW2 A;  3GTD A;  1U15 A;  2YV5 A;  1TJ7 A;  4V2R A;  4L6A A;  4IQJ M;  2OHY A;  2FUS A;  3GZH A;  2YII A;  4BAB A;  1GKM A;  1K7W A;  2JAR A;  1MH9 A;  5EYV A;  1FUP A;  3CI0 K;  3U13 A;  1FUO A;  3NZ4 A;  2O7B A; 
#chains in the Genus database with same CATH homology
 1FUQ A;  1FUR A;  2QVE A;  3OCE A;  2QGA B;  4NSL A;  1AUW A;  2NYN A;  1KQ7 A;  1U16 A;  3C8T A;  2PFM A;  2O6Y A;  3RRP A;  2PTR A;  1I0A A;  1C3C A;  4ADM A;  2NYF A;  3UNV A;  4NLE A;  1Y2M A;  3OCF A;  1W27 A;  1T6P A;  4MX2 A;  3QBP A;  3BHG A;  2J91 A;  4C5S A;  4CQ5 A;  1C3U A;  4APB A;  1J3U A;  1T6J A;  2O7F A;  3R6V A;  1YIS A;  1GK3 A;  1YFM A;  3KDY A;  1RE5 A;  2RJR A;  3R6Q A;  4HGV A;  1JSW A;  2E9F A;  1DOF A;  3TV2 A;  4C5U A;  4EEI A;  1HY0 A;  4V2Q A;  1YFE A;  4BAA A;  4APA A;  2RJS A;  1GKJ A;  4FLC A;  2O7E A;  1VDK A;  4EFC A;  4C5R A;  1HY1 A;  1DCN A;  4FFX A;  5D6B A;  3E04 A;  1GK2 A;  1XWO A;  2PTQ A;  5EYT A;  2PTS A;  1TJW A;  1B8F A;  2O78 A;  3RD8 A;  4C6G A;  3NO9 A;  1Q5N A;  1EB4 A;  4ADL A;  2X75 A;  1K62 A;  2VD6 A;  3CZO A;  1TJV A;  5F91 A;  2O7D A;  5F92 A;  1TJU A;  3KDZ A;  3R6Y A;  2HVG A;  5HW2 A;  3GTD A;  1U15 A;  1TJ7 A;  4V2R A;  2OHY A;  2FUS A;  3GZH A;  2YII A;  4BAB A;  1GKM A;  1K7W A;  5EYV A;  1FUP A;  1FUO A;  3NZ4 A;  2O7B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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