3E04A

Crystal structure of human fumarate hydratase
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
461
structure length
456
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human fumarate hydratase
rcsb
source organism Homo sapiens
molecule tags Lyase
molecule keywords Fumarate hydratase
total genus 175
structure length 456
sequence length 461
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2008-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3e04A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3e04A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3e04A02
4ADLA 2PTQA 1DOFA 2O78A 1KQ7A 4APAA 4BABA 5F92A 2FUSA 1T6PA 1HY0A 2O7FA 4C5UA 1U16A 2RJRA 3UNVA 1YFMA 3CZOA 3NZ4A 1DCNA 5EYTA 4NLEA 2O7EA 4C6GA 2YIIA 1YISA 1YFEA 1T6JA 1U15A 1W27A 3R6QA 2PFMA 1TJ7A 5D6BA 4HGVA 4EEIA 5F91A 1FURA 2O6YA 4BAAA 3OCFA 1Y2MA 1AUWA 1TJVA 4NSLA 3C8TA 1GKJA 4V2QA 3GZHA 1RE5A 3QBPA 5EYVA 2OHYA 3KDZA 4C5SA 1TJUA 4V2RA 3OCEA 1GK2A 2PTSA 1GKMA 2QGAB 1I0AA 1K7WA 3TV2A 3E04A 1XWOA 1C3UA 3KDYA 2VD6A 2X75A 1FUQA 2NYFA 1J3UA 4FFXA 4FLCA 1K62A 3BHGA 1B8FA 1JSWA 2QVEA 4CQ5A 3R6YA 2E9FA 2NYNA 2RJSA 4MX2A 3GTDA 1TJWA 1FUPA 2O7BA 3RRPA 3NO9A 4APBA 2HVGA 4ADMA 1C3CA 1VDKA 4EFCA 4C5RA 5HW2A 1FUOA 1Q5NA 3R6VA 1HY1A 1EB4A 1GK3A 2O7DA 2J91A 3RD8A 2PTRA
chains in the Genus database with same CATH superfamily
3F4SA 1Z4LA 2JAWA 4ADLA 2PTQA 1DOFA 1MH9A 4IQJM 2VL7A 2O78A 1KQ7A 2FENA 4APAA 1Q92A 4BABA 2JARA 5F92A 2FUSA 4E88A 1T6PA 1HY0A 2O7FA 4C5UA 1Q91A 1U16A 2RJRA 3UNVA 1YFMA 2VSFA 3CZOA 3NZ4A 1DCNA 1XL8A 4NLEA 3F4RA 5EYTA 4L6CA 2JAUA 2O7EA 1IW7D 4C6GA 2YIIA 1YISA 1YFEA 1T6JA 1U15A 1W27A 3R6QA 2PFMA 3U13A 1TJ7A 5D6BA 1Z4JA 4HGVA 4EEIA 5F91A 1FURA 2O6YA 1XMDA 3CRVA 4BAAA 3OCFA 1Y2MA 1AUWA 1TJVA 4NSLA 1Z4PX 3C8TA 4L6AA 1GKJA 2I7DA 4V2QA 3GZHA 1RE5A 3QBPA 5H8WA 2D28C 5EYVA 2OHYA 3KDZA 4C5SA 1TJUA 4YIHA 4NFLA 4V2RA 2RCNA 1XL7A 3OCEA 1GK2A 2PTSA 1GKMA 2QGAB 1I0AA 1Z4QA 1K7WA 3TV2A 4A15A 3E04A 1XWOA 1C3UA 3KDYA 1Z4MA 2VD6A 3F4TA 2D27A 2X75A 1FUQA 5M0JA 2NYFA 1J3UA 4FFXA 4FLCA 1K62A 3BHGA 1B8FA 3CI0K 1JSWA 2QVEA 4CQ5A 3R6YA 4MWOA 1XLYA 2E9FA 2NYNA 2RJSA 4MX2A 2YV5A 3GTDA 1Z4IA 1TJWA 1FUPA 2O7BA 2FELA 4L57A 3RRPA 3NO9A 4WNLA 4APBA 2HVGA 4ADMA 1C3CA 1VDKA 4EFCA 4C5RA 5M0IA 5HW2A 1FUOA 4YIKA 1Q5NA 3R6VA 1XMCA 1HY1A 3BWVA 1U0LA 1Z4KA 1EB4A 2JAOA 4MUMA 1GK3A 2O7DA 2J91A 3CRW1 3U19A 3RD8A 2PTRA 1T9HA
chains in the Genus database with same CATH topology
4ADLA 2PTQA 1DOFA 2O78A 1KQ7A 4APAA 4BABA 5F92A 2FUSA 1T6PA 1HY0A 2O7FA 4C5UA 1U16A 2RJRA 3UNVA 1YFMA 3CZOA 3NZ4A 1DCNA 5EYTA 4NLEA 2O7EA 4C6GA 2YIIA 1YISA 1YFEA 1T6JA 1U15A 1W27A 3R6QA 2PFMA 1TJ7A 5D6BA 4HGVA 4EEIA 5F91A 1FURA 2O6YA 4BAAA 3OCFA 1Y2MA 1AUWA 1TJVA 4NSLA 3C8TA 1GKJA 4V2QA 3GZHA 1RE5A 3QBPA 5EYVA 2OHYA 3KDZA 4C5SA 1TJUA 4V2RA 3OCEA 1GK2A 2PTSA 1GKMA 2QGAB 1I0AA 1K7WA 3TV2A 3E04A 1XWOA 1C3UA 3KDYA 2VD6A 2X75A 1FUQA 2NYFA 1J3UA 4FFXA 4FLCA 1K62A 3BHGA 1B8FA 1JSWA 2QVEA 4CQ5A 3R6YA 2E9FA 2NYNA 2RJSA 4MX2A 3GTDA 1TJWA 1FUPA 2O7BA 3RRPA 3NO9A 4APBA 2HVGA 4ADMA 1C3CA 1VDKA 4EFCA 4C5RA 5HW2A 1FUOA 1Q5NA 3R6VA 1HY1A 1EB4A 1GK3A 2O7DA 2J91A 3RD8A 2PTRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ADL A;  2PTQ A;  1DOF A;  2O78 A;  1KQ7 A;  4APA A;  4BAB A;  5F92 A;  2FUS A;  1T6P A;  1HY0 A;  2O7F A;  4C5U A;  1U16 A;  2RJR A;  3UNV A;  1YFM A;  3CZO A;  3NZ4 A;  1DCN A;  5EYT A;  4NLE A;  2O7E A;  4C6G A;  2YII A;  1YIS A;  1YFE A;  1T6J A;  1U15 A;  1W27 A;  3R6Q A;  2PFM A;  1TJ7 A;  5D6B A;  4HGV A;  4EEI A;  5F91 A;  1FUR A;  2O6Y A;  4BAA A;  3OCF A;  1Y2M A;  1AUW A;  1TJV A;  4NSL A;  3C8T A;  1GKJ A;  4V2Q A;  3GZH A;  1RE5 A;  3QBP A;  5EYV A;  2OHY A;  3KDZ A;  4C5S A;  1TJU A;  4V2R A;  3OCE A;  1GK2 A;  2PTS A;  1GKM A;  2QGA B;  1I0A A;  1K7W A;  3TV2 A;  3E04 A;  1XWO A;  1C3U A;  3KDY A;  2VD6 A;  2X75 A;  1FUQ A;  2NYF A;  1J3U A;  4FFX A;  4FLC A;  1K62 A;  3BHG A;  1B8F A;  1JSW A;  2QVE A;  4CQ5 A;  3R6Y A;  2E9F A;  2NYN A;  2RJS A;  4MX2 A;  3GTD A;  1TJW A;  1FUP A;  2O7B A;  3RRP A;  3NO9 A;  4APB A;  2HVG A;  4ADM A;  1C3C A;  1VDK A;  4EFC A;  4C5R A;  5HW2 A;  1FUO A;  1Q5N A;  3R6V A;  1HY1 A;  1EB4 A;  1GK3 A;  2O7D A;  2J91 A;  3RD8 A;  2PTR A; 
#chains in the Genus database with same CATH topology
 3F4S A;  1Z4L A;  2JAW A;  4ADL A;  2PTQ A;  1DOF A;  1MH9 A;  4IQJ M;  2VL7 A;  2O78 A;  1KQ7 A;  2FEN A;  4APA A;  1Q92 A;  4BAB A;  2JAR A;  5F92 A;  2FUS A;  4E88 A;  1T6P A;  1HY0 A;  2O7F A;  4C5U A;  1Q91 A;  1U16 A;  2RJR A;  3UNV A;  1YFM A;  2VSF A;  3CZO A;  3NZ4 A;  1DCN A;  1XL8 A;  4NLE A;  3F4R A;  5EYT A;  4L6C A;  2JAU A;  2O7E A;  1IW7 D;  4C6G A;  2YII A;  1YIS A;  1YFE A;  1T6J A;  1U15 A;  1W27 A;  3R6Q A;  2PFM A;  3U13 A;  1TJ7 A;  5D6B A;  1Z4J A;  4HGV A;  4EEI A;  5F91 A;  1FUR A;  2O6Y A;  1XMD A;  3CRV A;  4BAA A;  3OCF A;  1Y2M A;  1AUW A;  1TJV A;  4NSL A;  1Z4P X;  3C8T A;  4L6A A;  1GKJ A;  2I7D A;  4V2Q A;  3GZH A;  1RE5 A;  3QBP A;  5H8W A;  2D28 C;  5EYV A;  2OHY A;  3KDZ A;  4C5S A;  1TJU A;  4YIH A;  4NFL A;  4V2R A;  2RCN A;  1XL7 A;  3OCE A;  1GK2 A;  2PTS A;  1GKM A;  2QGA B;  1I0A A;  1Z4Q A;  1K7W A;  3TV2 A;  4A15 A;  3E04 A;  1XWO A;  1C3U A;  3KDY A;  1Z4M A;  2VD6 A;  3F4T A;  2D27 A;  2X75 A;  1FUQ A;  5M0J A;  2NYF A;  1J3U A;  4FFX A;  4FLC A;  1K62 A;  3BHG A;  1B8F A;  3CI0 K;  1JSW A;  2QVE A;  4CQ5 A;  3R6Y A;  4MWO A;  1XLY A;  2E9F A;  2NYN A;  2RJS A;  4MX2 A;  2YV5 A;  3GTD A;  1Z4I A;  1TJW A;  1FUP A;  2O7B A;  2FEL A;  4L57 A;  3RRP A;  3NO9 A;  4WNL A;  4APB A;  2HVG A;  4ADM A;  1C3C A;  1VDK A;  4EFC A;  4C5R A;  5M0I A;  5HW2 A;  1FUO A;  4YIK A;  1Q5N A;  3R6V A;  1XMC A;  1HY1 A;  3BWV A;  1U0L A;  1Z4K A;  1EB4 A;  2JAO A;  4MUM A;  1GK3 A;  2O7D A;  2J91 A;  3CRW 1;  3U19 A;  3RD8 A;  2PTR A;  1T9H A; 
#chains in the Genus database with same CATH homology
 4ADL A;  2PTQ A;  1DOF A;  2O78 A;  1KQ7 A;  4APA A;  4BAB A;  5F92 A;  2FUS A;  1T6P A;  1HY0 A;  2O7F A;  4C5U A;  1U16 A;  2RJR A;  3UNV A;  1YFM A;  3CZO A;  3NZ4 A;  1DCN A;  5EYT A;  4NLE A;  2O7E A;  4C6G A;  2YII A;  1YIS A;  1YFE A;  1T6J A;  1U15 A;  1W27 A;  3R6Q A;  2PFM A;  1TJ7 A;  5D6B A;  4HGV A;  4EEI A;  5F91 A;  1FUR A;  2O6Y A;  4BAA A;  3OCF A;  1Y2M A;  1AUW A;  1TJV A;  4NSL A;  3C8T A;  1GKJ A;  4V2Q A;  3GZH A;  1RE5 A;  3QBP A;  5EYV A;  2OHY A;  3KDZ A;  4C5S A;  1TJU A;  4V2R A;  3OCE A;  1GK2 A;  2PTS A;  1GKM A;  2QGA B;  1I0A A;  1K7W A;  3TV2 A;  3E04 A;  1XWO A;  1C3U A;  3KDY A;  2VD6 A;  2X75 A;  1FUQ A;  2NYF A;  1J3U A;  4FFX A;  4FLC A;  1K62 A;  3BHG A;  1B8F A;  1JSW A;  2QVE A;  4CQ5 A;  3R6Y A;  2E9F A;  2NYN A;  2RJS A;  4MX2 A;  3GTD A;  1TJW A;  1FUP A;  2O7B A;  3RRP A;  3NO9 A;  4APB A;  2HVG A;  4ADM A;  1C3C A;  1VDK A;  4EFC A;  4C5R A;  5HW2 A;  1FUO A;  1Q5N A;  3R6V A;  1HY1 A;  1EB4 A;  1GK3 A;  2O7D A;  2J91 A;  3RD8 A;  2PTR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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