3E04A

Crystal structure of human fumarate hydratase
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
461
structure length
456
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
source organism Homo sapiens
publication title Crystal structure of human fumarate hydratase
rcsb
molecule keywords Fumarate hydratase
total genus 175
structure length 456
sequence length 461
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2008-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3e04A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3e04A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3e04A02
3C8TA 3OCFA 2X75A 4BABA 1KQ7A 2O7FA 1VDKA 2VD6A 1YISA 3GTDA 2O7EA 1RE5A 2FUSA 4C5SA 4C6GA 2PTQA 1DCNA 1HY0A 1FURA 4CQ5A 1GK2A 4HGVA 1FUOA 2OHYA 2J91A 1TJUA 3RD8A 2NYFA 1AUWA 3RRPA 5EYTA 4ADMA 1TJWA 5HW2A 3UNVA 1YFMA 1I0AA 1Q5NA 5EYVA 2QVEA 1XWOA 4C5RA 1FUQA 2E9FA 4FLCA 4NLEA 3KDZA 1HY1A 5F91A 4V2QA 1K62A 1GKJA 2O7BA 3NO9A 3TV2A 1YFEA 4C5UA 2PTRA 3QBPA 1J3UA 3NZ4A 2O7DA 3R6VA 4ADLA 2NYNA 2PFMA 2O78A 2QGAB 2RJSA 1B8FA 1JSWA 1GK3A 1T6PA 1W27A 1T6JA 4V2RA 2RJRA 4EEIA 1FUPA 1K7WA 1U15A 3KDYA 2HVGA 3OCEA 5D6BA 4MX2A 4FFXA 2PTSA 1EB4A 1TJ7A 4NSLA 4BAAA 3E04A 1DOFA 3R6QA 1U16A 2O6YA 1GKMA 3R6YA 1C3CA 3CZOA 2YIIA 4APAA 1C3UA 1TJVA 3BHGA 4APBA 4EFCA 1Y2MA 3GZHA 5F92A
chains in the Genus database with same CATH superfamily
3C8TA 1MH9A 2I7DA 2FELA 1Z4IA 3OCFA 1Q91A 2X75A 4BABA 1KQ7A 2O7FA 1VDKA 1Z4JA 4L6CA 2VD6A 1YISA 3GTDA 2O7EA 1RE5A 2FUSA 1XMDA 4C6GA 4C5SA 2PTQA 1DCNA 1HY0A 1FURA 4MWOA 4CQ5A 1GK2A 4HGVA 1FUOA 2OHYA 2J91A 1TJUA 1XL7A 3RD8A 2NYFA 1AUWA 3RRPA 5EYTA 4ADMA 1IW7D 4YIHA 1TJWA 5HW2A 3UNVA 1YFMA 3U13A 1I0AA 1Q5NA 4L6AA 5EYVA 4IQJM 2JAOA 2QVEA 1XWOA 3BWVA 4C5RA 2D27A 1FUQA 2E9FA 4FLCA 4NLEA 3KDZA 1HY1A 5F91A 4MUMA 4V2QA 1K62A 1GKJA 1Z4PX 2O7BA 1XL8A 3F4RA 3NO9A 2FENA 3TV2A 3CI0K 3CRVA 1YFEA 1Z4MA 4C5UA 2PTRA 3F4SA 2D28C 3QBPA 1J3UA 5F92A 3NZ4A 4WNLA 2O7DA 3R6VA 4ADLA 2NYNA 2PFMA 4A15A 2O78A 2QGAB 4E88A 3CRW1 2RJSA 1B8FA 1JSWA 1GK3A 1T6PA 1W27A 4YIKA 1T6JA 1Z4KA 1XLYA 4V2RA 1Z4LA 2RJRA 2JARA 4EEIA 1FUPA 1K7WA 1U15A 3KDYA 2YV5A 2HVGA 2VL7A 3OCEA 4MX2A 5M0IA 4FFXA 2JAWA 1T9HA 2PTSA 1Z4QA 4NFLA 3U19A 1EB4A 1TJ7A 2VSFA 4NSLA 1XMCA 2RCNA 3F4TA 4BAAA 3E04A 1DOFA 2JAUA 3R6QA 1U16A 5M0JA 2O6YA 1GKMA 3R6YA 1C3CA 3CZOA 2YIIA 4APAA 5H8WA 1C3UA 1Q92A 1TJVA 3BHGA 1U0LA 4APBA 4EFCA 1Y2MA 3GZHA 4L57A 5D6BA
chains in the Genus database with same CATH topology
3C8TA 3OCFA 2X75A 4BABA 1KQ7A 2O7FA 1VDKA 2VD6A 1YISA 3GTDA 2O7EA 1RE5A 2FUSA 4C5SA 4C6GA 2PTQA 1DCNA 1HY0A 1FURA 4CQ5A 1GK2A 4HGVA 1FUOA 2OHYA 2J91A 1TJUA 3RD8A 2NYFA 1AUWA 3RRPA 5EYTA 4ADMA 1TJWA 5HW2A 3UNVA 1YFMA 1I0AA 1Q5NA 5EYVA 2QVEA 1XWOA 4C5RA 1FUQA 2E9FA 4FLCA 4NLEA 3KDZA 1HY1A 5F91A 4V2QA 1K62A 1GKJA 2O7BA 3NO9A 3TV2A 1YFEA 4C5UA 2PTRA 3QBPA 1J3UA 3NZ4A 2O7DA 3R6VA 4ADLA 2NYNA 2PFMA 2O78A 2QGAB 2RJSA 1B8FA 1JSWA 1GK3A 1T6PA 1W27A 1T6JA 4V2RA 2RJRA 4EEIA 1FUPA 1K7WA 1U15A 3KDYA 2HVGA 3OCEA 5D6BA 4MX2A 4FFXA 2PTSA 1EB4A 1TJ7A 4NSLA 4BAAA 3E04A 1DOFA 3R6QA 1U16A 2O6YA 1GKMA 3R6YA 1C3CA 3CZOA 2YIIA 4APAA 1C3UA 1TJVA 3BHGA 4APBA 4EFCA 1Y2MA 3GZHA 5F92A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C8T A;  3OCF A;  2X75 A;  4BAB A;  1KQ7 A;  2O7F A;  1VDK A;  2VD6 A;  1YIS A;  3GTD A;  2O7E A;  1RE5 A;  2FUS A;  4C5S A;  4C6G A;  2PTQ A;  1DCN A;  1HY0 A;  1FUR A;  4CQ5 A;  1GK2 A;  4HGV A;  1FUO A;  2OHY A;  2J91 A;  1TJU A;  3RD8 A;  2NYF A;  1AUW A;  3RRP A;  5EYT A;  4ADM A;  1TJW A;  5HW2 A;  3UNV A;  1YFM A;  1I0A A;  1Q5N A;  5EYV A;  2QVE A;  1XWO A;  4C5R A;  1FUQ A;  2E9F A;  4FLC A;  4NLE A;  3KDZ A;  1HY1 A;  5F91 A;  4V2Q A;  1K62 A;  1GKJ A;  2O7B A;  3NO9 A;  3TV2 A;  1YFE A;  4C5U A;  2PTR A;  3QBP A;  1J3U A;  3NZ4 A;  2O7D A;  3R6V A;  4ADL A;  2NYN A;  2PFM A;  2O78 A;  2QGA B;  2RJS A;  1B8F A;  1JSW A;  1GK3 A;  1T6P A;  1W27 A;  1T6J A;  4V2R A;  2RJR A;  4EEI A;  1FUP A;  1K7W A;  1U15 A;  3KDY A;  2HVG A;  3OCE A;  5D6B A;  4MX2 A;  4FFX A;  2PTS A;  1EB4 A;  1TJ7 A;  4NSL A;  4BAA A;  3E04 A;  1DOF A;  3R6Q A;  1U16 A;  2O6Y A;  1GKM A;  3R6Y A;  1C3C A;  3CZO A;  2YII A;  4APA A;  1C3U A;  1TJV A;  3BHG A;  4APB A;  4EFC A;  1Y2M A;  3GZH A;  5F92 A; 
#chains in the Genus database with same CATH topology
 3C8T A;  1MH9 A;  2I7D A;  2FEL A;  1Z4I A;  3OCF A;  1Q91 A;  2X75 A;  4BAB A;  1KQ7 A;  2O7F A;  1VDK A;  1Z4J A;  4L6C A;  2VD6 A;  1YIS A;  3GTD A;  2O7E A;  1RE5 A;  2FUS A;  1XMD A;  4C6G A;  4C5S A;  2PTQ A;  1DCN A;  1HY0 A;  1FUR A;  4MWO A;  4CQ5 A;  1GK2 A;  4HGV A;  1FUO A;  2OHY A;  2J91 A;  1TJU A;  1XL7 A;  3RD8 A;  2NYF A;  1AUW A;  3RRP A;  5EYT A;  4ADM A;  1IW7 D;  4YIH A;  1TJW A;  5HW2 A;  3UNV A;  1YFM A;  3U13 A;  1I0A A;  1Q5N A;  4L6A A;  5EYV A;  4IQJ M;  2JAO A;  2QVE A;  1XWO A;  3BWV A;  4C5R A;  2D27 A;  1FUQ A;  2E9F A;  4FLC A;  4NLE A;  3KDZ A;  1HY1 A;  5F91 A;  4MUM A;  4V2Q A;  1K62 A;  1GKJ A;  1Z4P X;  2O7B A;  1XL8 A;  3F4R A;  3NO9 A;  2FEN A;  3TV2 A;  3CI0 K;  3CRV A;  1YFE A;  1Z4M A;  4C5U A;  2PTR A;  3F4S A;  2D28 C;  3QBP A;  1J3U A;  5F92 A;  3NZ4 A;  4WNL A;  2O7D A;  3R6V A;  4ADL A;  2NYN A;  2PFM A;  4A15 A;  2O78 A;  2QGA B;  4E88 A;  3CRW 1;  2RJS A;  1B8F A;  1JSW A;  1GK3 A;  1T6P A;  1W27 A;  4YIK A;  1T6J A;  1Z4K A;  1XLY A;  4V2R A;  1Z4L A;  2RJR A;  2JAR A;  4EEI A;  1FUP A;  1K7W A;  1U15 A;  3KDY A;  2YV5 A;  2HVG A;  2VL7 A;  3OCE A;  4MX2 A;  5M0I A;  4FFX A;  2JAW A;  1T9H A;  2PTS A;  1Z4Q A;  4NFL A;  3U19 A;  1EB4 A;  1TJ7 A;  2VSF A;  4NSL A;  1XMC A;  2RCN A;  3F4T A;  4BAA A;  3E04 A;  1DOF A;  2JAU A;  3R6Q A;  1U16 A;  5M0J A;  2O6Y A;  1GKM A;  3R6Y A;  1C3C A;  3CZO A;  2YII A;  4APA A;  5H8W A;  1C3U A;  1Q92 A;  1TJV A;  3BHG A;  1U0L A;  4APB A;  4EFC A;  1Y2M A;  3GZH A;  4L57 A;  5D6B A; 
#chains in the Genus database with same CATH homology
 3C8T A;  3OCF A;  2X75 A;  4BAB A;  1KQ7 A;  2O7F A;  1VDK A;  2VD6 A;  1YIS A;  3GTD A;  2O7E A;  1RE5 A;  2FUS A;  4C5S A;  4C6G A;  2PTQ A;  1DCN A;  1HY0 A;  1FUR A;  4CQ5 A;  1GK2 A;  4HGV A;  1FUO A;  2OHY A;  2J91 A;  1TJU A;  3RD8 A;  2NYF A;  1AUW A;  3RRP A;  5EYT A;  4ADM A;  1TJW A;  5HW2 A;  3UNV A;  1YFM A;  1I0A A;  1Q5N A;  5EYV A;  2QVE A;  1XWO A;  4C5R A;  1FUQ A;  2E9F A;  4FLC A;  4NLE A;  3KDZ A;  1HY1 A;  5F91 A;  4V2Q A;  1K62 A;  1GKJ A;  2O7B A;  3NO9 A;  3TV2 A;  1YFE A;  4C5U A;  2PTR A;  3QBP A;  1J3U A;  3NZ4 A;  2O7D A;  3R6V A;  4ADL A;  2NYN A;  2PFM A;  2O78 A;  2QGA B;  2RJS A;  1B8F A;  1JSW A;  1GK3 A;  1T6P A;  1W27 A;  1T6J A;  4V2R A;  2RJR A;  4EEI A;  1FUP A;  1K7W A;  1U15 A;  3KDY A;  2HVG A;  3OCE A;  5D6B A;  4MX2 A;  4FFX A;  2PTS A;  1EB4 A;  1TJ7 A;  4NSL A;  4BAA A;  3E04 A;  1DOF A;  3R6Q A;  1U16 A;  2O6Y A;  1GKM A;  3R6Y A;  1C3C A;  3CZO A;  2YII A;  4APA A;  1C3U A;  1TJV A;  3BHG A;  4APB A;  4EFC A;  1Y2M A;  3GZH A;  5F92 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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