3E04A

Crystal structure of human fumarate hydratase
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
461
structure length
456
Chain Sequence
b'SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGP'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of human fumarate hydratase
rcsb
molecule keywords Fumarate hydratase
source organism Homo sapiens
molecule tags Lyase
total genus 175
structure length 456
sequence length 461
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2008-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3e04A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3e04A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3e04A02
4C5UA 4BAAA 1YFEA 2PFMA 1J3UA 4MX2A 2NYNA 3R6VA 4BABA 5F91A 1FUOA 1XWOA 3OCEA 4NSLA 4C6GA 2O7BA 4FLCA 1K62A 3R6QA 1EB4A 2X75A 3NO9A 1C3UA 3GTDA 3RD8A 3NZ4A 1FUPA 2RJRA 5F92A 5EYVA 2J91A 1YFMA 1DCNA 2VD6A 2O7FA 4FFXA 1YISA 2PTQA 2QVEA 1T6JA 4CQ5A 1AUWA 2OHYA 2O7EA 4NLEA 1GKJA 3KDYA 3RRPA 1K7WA 1TJ7A 1TJWA 1C3CA 1GK3A 2O78A 1HY0A 3QBPA 1U15A 1U16A 2HVGA 1FURA 1Q5NA 5D6BA 4HGVA 1HY1A 3TV2A 1GKMA 2PTRA 3BHGA 5EYTA 1B8FA 4ADLA 3CZOA 5HW2A 1FUQA 1T6PA 1TJUA 3C8TA 1TJVA 1RE5A 2O6YA 4EFCA 2NYFA 4C5RA 2PTSA 4ADMA 2YIIA 3UNVA 3E04A 1Y2MA 1KQ7A 2RJSA 1JSWA 3OCFA 2FUSA 4C5SA 1W27A 4APBA 2E9FA 2O7DA 4EEIA 1GK2A 1DOFA 3KDZA 4APAA 4V2QA 4V2RA 3R6YA 1VDKA 3GZHA 1I0AA 2QGAB
chains in the Genus database with same CATH superfamily
3F4TA 2FENA 4C5UA 4BAAA 1YFEA 2VSFA 2PFMA 1J3UA 4MX2A 2VL7A 2NYNA 3R6VA 4BABA 2JAWA 1XL8A 5F91A 1FUOA 1XWOA 1IW7D 1Z4JA 1XMDA 5H8WA 3OCEA 4YIHA 4NSLA 1Z4PX 4C6GA 1Z4IA 2O7BA 4FLCA 1K62A 3R6QA 1EB4A 2X75A 1Z4MA 3NO9A 1C3UA 3GTDA 1XLYA 1Q91A 3RD8A 3NZ4A 1FUPA 2RJRA 5F92A 5EYVA 4WNLA 2J91A 1U0LA 1YFMA 1DCNA 2VD6A 2YV5A 4MWOA 2O7FA 4FFXA 1YISA 3BWVA 2PTQA 2QVEA 3F4RA 1T6JA 4CQ5A 1AUWA 2I7DA 3U19A 2OHYA 2O7EA 4L57A 4NLEA 2JAOA 1GKJA 3KDYA 3RRPA 1T9HA 1K7WA 1TJ7A 1TJWA 1C3CA 1GK3A 2O78A 1XMCA 1Z4QA 1HY0A 4L6CA 4E88A 3QBPA 1U15A 3F4SA 1U16A 2HVGA 1FURA 2D28C 2FELA 1Q5NA 5D6BA 4L6AA 4HGVA 1HY1A 3TV2A 1GKMA 4IQJM 2PTRA 3BHGA 4A15A 5EYTA 1B8FA 4ADLA 1Z4LA 3CZOA 5HW2A 1FUQA 1TJUA 4MUMA 3C8TA 1T6PA 1TJVA 1RE5A 4NFLA 2O6YA 4EFCA 3U13A 2NYFA 4YIKA 4C5RA 2PTSA 4ADMA 5M0IA 2YIIA 3UNVA 2RCNA 3E04A 1Y2MA 1KQ7A 2RJSA 1JSWA 3OCFA 2FUSA 1Z4KA 3CRVA 1Q92A 1MH9A 2JAUA 4C5SA 1W27A 4APBA 3CI0K 2E9FA 5M0JA 2D27A 2O7DA 4EEIA 1GK2A 2JARA 1DOFA 3KDZA 4APAA 1XL7A 4V2QA 4V2RA 3R6YA 1VDKA 3GZHA 1I0AA 3CRW1 2QGAB
chains in the Genus database with same CATH topology
4C5UA 4BAAA 1YFEA 2PFMA 1J3UA 4MX2A 2NYNA 3R6VA 4BABA 5F91A 1FUOA 1XWOA 3OCEA 4NSLA 4C6GA 2O7BA 4FLCA 1K62A 3R6QA 1EB4A 2X75A 3NO9A 1C3UA 3GTDA 3RD8A 3NZ4A 1FUPA 2RJRA 5F92A 5EYVA 2J91A 1YFMA 1DCNA 2VD6A 2O7FA 4FFXA 1YISA 2PTQA 2QVEA 1T6JA 4CQ5A 1AUWA 2OHYA 2O7EA 4NLEA 1GKJA 3KDYA 3RRPA 1K7WA 1TJ7A 1TJWA 1C3CA 1GK3A 2O78A 1HY0A 3QBPA 1U15A 1U16A 2HVGA 1FURA 1Q5NA 5D6BA 4HGVA 1HY1A 3TV2A 1GKMA 2PTRA 3BHGA 5EYTA 1B8FA 4ADLA 3CZOA 5HW2A 1FUQA 1T6PA 1TJUA 3C8TA 1TJVA 1RE5A 2O6YA 4EFCA 2NYFA 4C5RA 2PTSA 4ADMA 2YIIA 3UNVA 3E04A 1Y2MA 1KQ7A 2RJSA 1JSWA 3OCFA 2FUSA 4C5SA 1W27A 4APBA 2E9FA 2O7DA 4EEIA 1GK2A 1DOFA 3KDZA 4APAA 4V2QA 4V2RA 3R6YA 1VDKA 3GZHA 1I0AA 2QGAB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C5U A;  4BAA A;  1YFE A;  2PFM A;  1J3U A;  4MX2 A;  2NYN A;  3R6V A;  4BAB A;  5F91 A;  1FUO A;  1XWO A;  3OCE A;  4NSL A;  4C6G A;  2O7B A;  4FLC A;  1K62 A;  3R6Q A;  1EB4 A;  2X75 A;  3NO9 A;  1C3U A;  3GTD A;  3RD8 A;  3NZ4 A;  1FUP A;  2RJR A;  5F92 A;  5EYV A;  2J91 A;  1YFM A;  1DCN A;  2VD6 A;  2O7F A;  4FFX A;  1YIS A;  2PTQ A;  2QVE A;  1T6J A;  4CQ5 A;  1AUW A;  2OHY A;  2O7E A;  4NLE A;  1GKJ A;  3KDY A;  3RRP A;  1K7W A;  1TJ7 A;  1TJW A;  1C3C A;  1GK3 A;  2O78 A;  1HY0 A;  3QBP A;  1U15 A;  1U16 A;  2HVG A;  1FUR A;  1Q5N A;  5D6B A;  4HGV A;  1HY1 A;  3TV2 A;  1GKM A;  2PTR A;  3BHG A;  5EYT A;  1B8F A;  4ADL A;  3CZO A;  5HW2 A;  1FUQ A;  1T6P A;  1TJU A;  3C8T A;  1TJV A;  1RE5 A;  2O6Y A;  4EFC A;  2NYF A;  4C5R A;  2PTS A;  4ADM A;  2YII A;  3UNV A;  3E04 A;  1Y2M A;  1KQ7 A;  2RJS A;  1JSW A;  3OCF A;  2FUS A;  4C5S A;  1W27 A;  4APB A;  2E9F A;  2O7D A;  4EEI A;  1GK2 A;  1DOF A;  3KDZ A;  4APA A;  4V2Q A;  4V2R A;  3R6Y A;  1VDK A;  3GZH A;  1I0A A;  2QGA B; 
#chains in the Genus database with same CATH topology
 3F4T A;  2FEN A;  4C5U A;  4BAA A;  1YFE A;  2VSF A;  2PFM A;  1J3U A;  4MX2 A;  2VL7 A;  2NYN A;  3R6V A;  4BAB A;  2JAW A;  1XL8 A;  5F91 A;  1FUO A;  1XWO A;  1IW7 D;  1Z4J A;  1XMD A;  5H8W A;  3OCE A;  4YIH A;  4NSL A;  1Z4P X;  4C6G A;  1Z4I A;  2O7B A;  4FLC A;  1K62 A;  3R6Q A;  1EB4 A;  2X75 A;  1Z4M A;  3NO9 A;  1C3U A;  3GTD A;  1XLY A;  1Q91 A;  3RD8 A;  3NZ4 A;  1FUP A;  2RJR A;  5F92 A;  5EYV A;  4WNL A;  2J91 A;  1U0L A;  1YFM A;  1DCN A;  2VD6 A;  2YV5 A;  4MWO A;  2O7F A;  4FFX A;  1YIS A;  3BWV A;  2PTQ A;  2QVE A;  3F4R A;  1T6J A;  4CQ5 A;  1AUW A;  2I7D A;  3U19 A;  2OHY A;  2O7E A;  4L57 A;  4NLE A;  2JAO A;  1GKJ A;  3KDY A;  3RRP A;  1T9H A;  1K7W A;  1TJ7 A;  1TJW A;  1C3C A;  1GK3 A;  2O78 A;  1XMC A;  1Z4Q A;  1HY0 A;  4L6C A;  4E88 A;  3QBP A;  1U15 A;  3F4S A;  1U16 A;  2HVG A;  1FUR A;  2D28 C;  2FEL A;  1Q5N A;  5D6B A;  4L6A A;  4HGV A;  1HY1 A;  3TV2 A;  1GKM A;  4IQJ M;  2PTR A;  3BHG A;  4A15 A;  5EYT A;  1B8F A;  4ADL A;  1Z4L A;  3CZO A;  5HW2 A;  1FUQ A;  1TJU A;  4MUM A;  3C8T A;  1T6P A;  1TJV A;  1RE5 A;  4NFL A;  2O6Y A;  4EFC A;  3U13 A;  2NYF A;  4YIK A;  4C5R A;  2PTS A;  4ADM A;  5M0I A;  2YII A;  3UNV A;  2RCN A;  3E04 A;  1Y2M A;  1KQ7 A;  2RJS A;  1JSW A;  3OCF A;  2FUS A;  1Z4K A;  3CRV A;  1Q92 A;  1MH9 A;  2JAU A;  4C5S A;  1W27 A;  4APB A;  3CI0 K;  2E9F A;  5M0J A;  2D27 A;  2O7D A;  4EEI A;  1GK2 A;  2JAR A;  1DOF A;  3KDZ A;  4APA A;  1XL7 A;  4V2Q A;  4V2R A;  3R6Y A;  1VDK A;  3GZH A;  1I0A A;  3CRW 1;  2QGA B; 
#chains in the Genus database with same CATH homology
 4C5U A;  4BAA A;  1YFE A;  2PFM A;  1J3U A;  4MX2 A;  2NYN A;  3R6V A;  4BAB A;  5F91 A;  1FUO A;  1XWO A;  3OCE A;  4NSL A;  4C6G A;  2O7B A;  4FLC A;  1K62 A;  3R6Q A;  1EB4 A;  2X75 A;  3NO9 A;  1C3U A;  3GTD A;  3RD8 A;  3NZ4 A;  1FUP A;  2RJR A;  5F92 A;  5EYV A;  2J91 A;  1YFM A;  1DCN A;  2VD6 A;  2O7F A;  4FFX A;  1YIS A;  2PTQ A;  2QVE A;  1T6J A;  4CQ5 A;  1AUW A;  2OHY A;  2O7E A;  4NLE A;  1GKJ A;  3KDY A;  3RRP A;  1K7W A;  1TJ7 A;  1TJW A;  1C3C A;  1GK3 A;  2O78 A;  1HY0 A;  3QBP A;  1U15 A;  1U16 A;  2HVG A;  1FUR A;  1Q5N A;  5D6B A;  4HGV A;  1HY1 A;  3TV2 A;  1GKM A;  2PTR A;  3BHG A;  5EYT A;  1B8F A;  4ADL A;  3CZO A;  5HW2 A;  1FUQ A;  1T6P A;  1TJU A;  3C8T A;  1TJV A;  1RE5 A;  2O6Y A;  4EFC A;  2NYF A;  4C5R A;  2PTS A;  4ADM A;  2YII A;  3UNV A;  3E04 A;  1Y2M A;  1KQ7 A;  2RJS A;  1JSW A;  3OCF A;  2FUS A;  4C5S A;  1W27 A;  4APB A;  2E9F A;  2O7D A;  4EEI A;  1GK2 A;  1DOF A;  3KDZ A;  4APA A;  4V2Q A;  4V2R A;  3R6Y A;  1VDK A;  3GZH A;  1I0A A;  2QGA B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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