3E6YA

Structure of 14-3-3 in complex with the differentiation-inducing agent cotylenin a
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
234
structure length
234
Chain Sequence
PTAREENVYMAKLAEQAERYEEMVEFMEKVSNSLGSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEEHVNSIREYRSKIENELSKICDGILKLLDAKLIPSAASGDSKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLTAYKAAQDIATTELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A
pubmed rcsb
molecule tags Signaling protein
source organism Nicotiana tabacum
molecule keywords 14-3-3-like protein C
total genus 101
structure length 234
sequence length 234
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 3e6yA00
3M51A 5LX2A 4Y32A 1O9CA 2O98A 4F7RA 3P1OA 5D2DA 5EXAA 2B05A 4IHLA 4J6SA 4N84A 5BY9A 3LW1A 4Y3BA 5J31A 1A38A 3T0MA 1QJBA 4DATA 1A37A 3CU8A 3SMNA 4IEAA 3UX0A 1A4OA 4E2EA 3EFZA 3SMKA 5IQPA 4N7YA 4DHQA 4DHSA 2O02A 3O8IA 5LVZA 4O46A 3RDHA 2WH0A 2V7DA 5LHOA 3IQVA 4DHOA 3IQJA 2C63A 3M50A 4WRQA 4DHNA 4DHRA 2BR9A 3NKXA 4N7GA 3SMOA 3P1RA 4Y5IA 2BTPA 3UBWA 3SMMA 5BTVA 1IB1A 4DHPA 3IQUA 4FJ3A 4GNTA 3SPRA 5LU1A 2BQ0A 3UZDA 5F74A 1O9DA 2O8PA 2C1JA 2C1NA 4JDDA 4HKCA 4ZDRA 3P1PA 5LU2A 3MHRA 4DNKA 4DHTA 1O9FA 3P1SA 4DAUA 2NPMA 5EWZA 4ZQ0A 4DHMA 3UALA 5D3FA 1QJAA 4FR3A 5HF3A 4BG6A 1YWTA 3U9XA 3E6YA 3SP5A 2C23A 4DX0A 4DHUA 3P1NA 2C74A 4FL5A 3T0LA 1O9EA 1YZ5A 3AXYC 3P1QA 5D3EA 4JC3A 3SMLA 4QLIA
chains in the Genus database with same CATH superfamily
3M51A 5LX2A 4QX3A 4Y32A 1W99A 1O9CA 2O98A 4F7RA 3P1OA 5D2DA 5EXAA 1CIYA 2B05A 4IHLA 4J6SA 4N84A 5BY9A 3LW1A 4Y3BA 5J31A 1A38A 3I4RA 3T0MA 1QJBA 4QX2A 4DATA 1A37A 3CU8A 3CQCA 3SMNA 4IEAA 4ARXA 3UX0A 1A4OA 4E2EA 3EFZA 3SMKA 5IQPA 4QX1A 4N7YA 4DHQA 4DHSA 4QX0A 4ARYA 1URJA 2O02A 3O8IA 5LVZA 4O46A 3RDHA 2WH0A 2V7DA 5LHOA 3IQVA 4DHOA 3IQJA 2C63A 3M50A 4WRQA 4DHNA 4DHRA 2BR9A 3CQGA 3NKXA 4N7GA 3X0UA 3SMOA 3P1RA 4Y5IA 2BTPA 3UBWA 3SMMA 5BTVA 1IB1A 4DHPA 3IQUA 3EB7A 4FJ3A 4GNTA 3SPRA 5LU1A 2BQ0A 4MOAA 3UZDA 5F74A 1O9DA 2O8PA 2C1JA 1JI6A 2C1NA 4JDDA 4HKCA 4ZDRA 3P1PA 5LU2A 3MHRA 4DNKA 1DLCA 4DHTA 1O9FA 3P1SA 4DAUA 2NPMA 5EWZA 4ZQ0A 4DHMA 3UALA 5D3FA 1QJAA 4D8MA 4FR3A 5HF3A 4BG6A 1YWTA 3U9XA 3E6YA 3SP5A 2C23A 4W8JA 4DX0A 4DHUA 1S2XA 3P1NA 2C74A 4FL5A 3T0LA 2C9KA 1O9EA 1YZ5A 3AXYC 3P1QA 5D3EA 3ZHEB 4JC3A 3SMLA 4QLIA 1I5PA
chains in the Genus database with same CATH topology
3M51A 5LX2A 4Y32A 1O9CA 2O98A 4F7RA 3P1OA 5D2DA 5EXAA 2B05A 4IHLA 4J6SA 4N84A 5BY9A 3LW1A 4Y3BA 5J31A 1A38A 3T0MA 1QJBA 4DATA 1A37A 3CU8A 3SMNA 4IEAA 3UX0A 1A4OA 4E2EA 3EFZA 3SMKA 5IQPA 4N7YA 4DHQA 4DHSA 2O02A 3O8IA 5LVZA 4O46A 3RDHA 2WH0A 2V7DA 5LHOA 3IQVA 4DHOA 3IQJA 2C63A 3M50A 4WRQA 4DHNA 4DHRA 2BR9A 3NKXA 4N7GA 3SMOA 3P1RA 4Y5IA 2BTPA 3UBWA 3SMMA 5BTVA 1IB1A 4DHPA 3IQUA 4FJ3A 4GNTA 3SPRA 5LU1A 2BQ0A 3UZDA 5F74A 1O9DA 2O8PA 2C1JA 2C1NA 4JDDA 4HKCA 4ZDRA 3P1PA 5LU2A 3MHRA 4DNKA 4DHTA 1O9FA 3P1SA 4DAUA 2NPMA 5EWZA 4ZQ0A 4DHMA 3UALA 5D3FA 1QJAA 4FR3A 5HF3A 4BG6A 1YWTA 3U9XA 3E6YA 3SP5A 2C23A 4DX0A 4DHUA 3P1NA 2C74A 4FL5A 3T0LA 1O9EA 1YZ5A 3AXYC 3P1QA 5D3EA 4JC3A 3SMLA 4QLIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M51 A;  5LX2 A;  4Y32 A;  1O9C A;  2O98 A;  4F7R A;  3P1O A;  5D2D A;  5EXA A;  2B05 A;  4IHL A;  4J6S A;  4N84 A;  5BY9 A;  3LW1 A;  4Y3B A;  5J31 A;  1A38 A;  3T0M A;  1QJB A;  4DAT A;  1A37 A;  3CU8 A;  3SMN A;  4IEA A;  3UX0 A;  1A4O A;  4E2E A;  3EFZ A;  3SMK A;  5IQP A;  4N7Y A;  4DHQ A;  4DHS A;  2O02 A;  3O8I A;  5LVZ A;  4O46 A;  3RDH A;  2WH0 A;  2V7D A;  5LHO A;  3IQV A;  4DHO A;  3IQJ A;  2C63 A;  3M50 A;  4WRQ A;  4DHN A;  4DHR A;  2BR9 A;  3NKX A;  4N7G A;  3SMO A;  3P1R A;  4Y5I A;  2BTP A;  3UBW A;  3SMM A;  5BTV A;  1IB1 A;  4DHP A;  3IQU A;  4FJ3 A;  4GNT A;  3SPR A;  5LU1 A;  2BQ0 A;  3UZD A;  5F74 A;  1O9D A;  2O8P A;  2C1J A;  2C1N A;  4JDD A;  4HKC A;  4ZDR A;  3P1P A;  5LU2 A;  3MHR A;  4DNK A;  4DHT A;  1O9F A;  3P1S A;  4DAU A;  2NPM A;  5EWZ A;  4ZQ0 A;  4DHM A;  3UAL A;  5D3F A;  1QJA A;  4FR3 A;  5HF3 A;  4BG6 A;  1YWT A;  3U9X A;  3E6Y A;  3SP5 A;  2C23 A;  4DX0 A;  4DHU A;  3P1N A;  2C74 A;  4FL5 A;  3T0L A;  1O9E A;  1YZ5 A;  3AXY C;  3P1Q A;  5D3E A;  4JC3 A;  3SML A;  4QLI A; 
#chains in the Genus database with same CATH topology
 3M51 A;  5LX2 A;  4QX3 A;  4Y32 A;  1W99 A;  1O9C A;  2O98 A;  4F7R A;  3P1O A;  5D2D A;  5EXA A;  1CIY A;  2B05 A;  4IHL A;  4J6S A;  4N84 A;  5BY9 A;  3LW1 A;  4Y3B A;  5J31 A;  1A38 A;  3I4R A;  3T0M A;  1QJB A;  4QX2 A;  4DAT A;  1A37 A;  3CU8 A;  3CQC A;  3SMN A;  4IEA A;  4ARX A;  3UX0 A;  1A4O A;  4E2E A;  3EFZ A;  3SMK A;  5IQP A;  4QX1 A;  4N7Y A;  4DHQ A;  4DHS A;  4QX0 A;  4ARY A;  1URJ A;  2O02 A;  3O8I A;  5LVZ A;  4O46 A;  3RDH A;  2WH0 A;  2V7D A;  5LHO A;  3IQV A;  4DHO A;  3IQJ A;  2C63 A;  3M50 A;  4WRQ A;  4DHN A;  4DHR A;  2BR9 A;  3CQG A;  3NKX A;  4N7G A;  3X0U A;  3SMO A;  3P1R A;  4Y5I A;  2BTP A;  3UBW A;  3SMM A;  5BTV A;  1IB1 A;  4DHP A;  3IQU A;  3EB7 A;  4FJ3 A;  4GNT A;  3SPR A;  5LU1 A;  2BQ0 A;  4MOA A;  3UZD A;  5F74 A;  1O9D A;  2O8P A;  2C1J A;  1JI6 A;  2C1N A;  4JDD A;  4HKC A;  4ZDR A;  3P1P A;  5LU2 A;  3MHR A;  4DNK A;  1DLC A;  4DHT A;  1O9F A;  3P1S A;  4DAU A;  2NPM A;  5EWZ A;  4ZQ0 A;  4DHM A;  3UAL A;  5D3F A;  1QJA A;  4D8M A;  4FR3 A;  5HF3 A;  4BG6 A;  1YWT A;  3U9X A;  3E6Y A;  3SP5 A;  2C23 A;  4W8J A;  4DX0 A;  4DHU A;  1S2X A;  3P1N A;  2C74 A;  4FL5 A;  3T0L A;  2C9K A;  1O9E A;  1YZ5 A;  3AXY C;  3P1Q A;  5D3E A;  3ZHE B;  4JC3 A;  3SML A;  4QLI A;  1I5P A; 
#chains in the Genus database with same CATH homology
 3M51 A;  5LX2 A;  4Y32 A;  1O9C A;  2O98 A;  4F7R A;  3P1O A;  5D2D A;  5EXA A;  2B05 A;  4IHL A;  4J6S A;  4N84 A;  5BY9 A;  3LW1 A;  4Y3B A;  5J31 A;  1A38 A;  3T0M A;  1QJB A;  4DAT A;  1A37 A;  3CU8 A;  3SMN A;  4IEA A;  3UX0 A;  1A4O A;  4E2E A;  3EFZ A;  3SMK A;  5IQP A;  4N7Y A;  4DHQ A;  4DHS A;  2O02 A;  3O8I A;  5LVZ A;  4O46 A;  3RDH A;  2WH0 A;  2V7D A;  5LHO A;  3IQV A;  4DHO A;  3IQJ A;  2C63 A;  3M50 A;  4WRQ A;  4DHN A;  4DHR A;  2BR9 A;  3NKX A;  4N7G A;  3SMO A;  3P1R A;  4Y5I A;  2BTP A;  3UBW A;  3SMM A;  5BTV A;  1IB1 A;  4DHP A;  3IQU A;  4FJ3 A;  4GNT A;  3SPR A;  5LU1 A;  2BQ0 A;  3UZD A;  5F74 A;  1O9D A;  2O8P A;  2C1J A;  2C1N A;  4JDD A;  4HKC A;  4ZDR A;  3P1P A;  5LU2 A;  3MHR A;  4DNK A;  4DHT A;  1O9F A;  3P1S A;  4DAU A;  2NPM A;  5EWZ A;  4ZQ0 A;  4DHM A;  3UAL A;  5D3F A;  1QJA A;  4FR3 A;  5HF3 A;  4BG6 A;  1YWT A;  3U9X A;  3E6Y A;  3SP5 A;  2C23 A;  4DX0 A;  4DHU A;  3P1N A;  2C74 A;  4FL5 A;  3T0L A;  1O9E A;  1YZ5 A;  3AXY C;  3P1Q A;  5D3E A;  4JC3 A;  3SML A;  4QLI A; 
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similar chains in the Genus database (?% sequence similarity)
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