3E8RA

Crystal structure of catalytic domain of tace with hydroxamate inhibitor
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
257
structure length
251
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords ADAM 17
total genus 80
structure length 251
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2008-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3e8rA00
1G12A 2O36A 2RJQA 4FVLA 2W12A 4G0DA 1WNIA 2O3EA 1B8YA 1G05A 5BOTA 1IAGA 5CXAA 5D1UA 1BQOA 1R1JA 2MZIA 3LJTA 3ZXHA 4PKVA 1AKLA 2X7MA 5D3CA 3Q2HA 2SRTA 2V4BA 1B3DA 1UMSA 1R55A 2D1NA 3WV1A 1Y0VA 2JNPA 5BOYA 3F16A 4AUOA 1XURA 830CA 4PKTA 1YQYA 2N8RA 3EDIA 2A8HA 3TVCA 3F18A 4JPAA 4IN9A 4H84A 1GKCA 2YIGA 3EDZA 4PKSA 1PWVA 3E8RA 3EHYA 2OVXA 1HV5A 1UTTA 1A85A 4HMAA 3DSLA 1JAPA 4R3VA 4L19A 4A3WA 3LIKA 1GO8P 5BPAA 4PKWA 1XFUA 1ROSA 2I47A 1OM7A 3AYUA 3ELMA 1CGLA 4AXQA 2X3BA 1C3IA 2Y6CA 456CA 3EDHA 4WKEA 3TS4A 1Y93A 3LJZA 5D7WA 4DD8A 2POJA 4GR8A 1ZXCA 1SU3A 3AIGA 4H82A 2FV9A 1UMTA 1D8MA 1OMJA 2EROA 3NX7A 5I0LA 1S4BP 1SATA 1SLNA 1HOVA 1JIWP 2JT6A 4CTHA 1K7GA 5I4OA 1BM6A 2TCLA 3CKIA 3Q2GA 4XCTA 4XBHA 1UEAA 4H49A 3BA0A 1BKCA 3EWJA 3KHIA 1ZP5A 3LEAA 3ZVSA 2OW2A 3I7IA 3USNA 3G42A 2Y6DA 4J4MA 3N2UA 1J7NA 4XM8A 3DPEA 2JIHA 5L79A 2OXZA 1OM6A 1HFSA 1PWQA 5L7FA 1KUKA 4PKRA 3K7LA 5JMYA 4I03A 1C8TA 1HFCA 4GR3A 1DTHA 3HY9A 1CAQA 3P1VA 4ZR5A 5D1SA 2Z2DA 5H8XA 4JP4A 4JIJA 3HDAP 5I12A 3HBUP 2DDFA 1KUGA 3L0TA 5CUHA 1JAQA 2OI0A 1EB6A 1MMBA 3HDBA 1XFZA 4DV8A 2L0RA 1IAAA 4L63A 1GXDA 3RTSA 1QUAA 1ZS0A 4AIGA 1XFVA 2MZEA 2OXUA 4PKQA 1CK7A 1XFXA 2W14A 2W15A 3RTTA 1EUBA 2AIGP 1KUIA 1R54A 4ILWD 3LUMA 1BUVM 2W0DA 1FBLA 1FLSA 4IJOA 2WO8A 4XM7A 4WZVA 3B92A 4FU4A 3DL1A 1KBCA 1QIBA 1SMPA 5B5OA 4GQLA 3LQ0A 2FV5A 2K2GA 5I43A 4L6TA 4DF9A 1KUHA 5B5PA 1XFWA 2CLTA 966CA 4JA1A 4AYKA 1BIWA 2XS3A 1ZXVA 1I73A 1IABA 3P24A 1D7XA 3VTGA 2OXWA 1ND1A 3VI1A 1QICA 3N2VA 2X3AA 4QKZA 1AF0A 5LABA 3EHXA 1JJ9A 2OY2A 2KRJA 1ZTQA 2AYKA 5D2BA 1UTZA 5CZMA 1I1IP 3LKAA 1K7QA 3LK8A 2OW9A 1IACA 4G9LA 3LIRA 1R1HA 1YCMA 1JIZA 3LGPA 4WK7A 1HY7A 1JANA 1O0QA 1O0TA 1QIAA 1GE5A 4GF1A 1SLMA 1KAPP 1MMPA 1YOUA 5I2ZA 4H76A 1GE7A 2DW2A 1PWPA 1D5JA 4DPEA 2DW1A 3F19A 1PWUA 1RMZA 1BSWA 1MMQA 2D1OA 3DNGA 2MZHA 1JH1A 2QPJA 1YP1A 1ATLA 2PJTA 4H30A 3WV3A 4ON1A 5I3MA 4GUYA 1CGEA 4PKUA 3HB2P 1CXVA 3KRYA 4EFSA 3O2XA 4JQGA 3UVCA 1A86A 1JAOA 1MNCA 3KWVC 3U1RA 2W13A 3LUNA 4H1QA 3B8ZA 1GKDA 4H3XA 2ERPA 4I35A 1DMTA 2JT5A 1AYKA 2ERQA 4WF6A 1XUCA 3F15A 1CIZA 1EAKA 2WOAA 1BUDA 3LMCA 4WKIA 2OZRA 1IADA 3LE9A 1C7KA 1BKCI 2HU6A 4IUWA 3KEJA 3O64A 2J0TA 2OW1A 3WV2A 3HY7A 3KEKA 2X3CA 4FXQA 1ZVXA 1Y8JA 1R1IA 3G5CA 1OS2A 2OVZA 2YB9A 1QJJA 1USNA 4HX3A 2K9CA 1BKCE 2J83A 2MLRA 3TSKA 4XM6A 3LJGA 3TT4A 1G9KA 3V96B 1MMRA 2JSDA 1IAEA 2USNA 3DWBA 1JK3A 1XFYA 3L0VA 1L6JA 1JKYA 1SRPA 2E2DA 3AYKA 4H2EA 3GBOA 1K7IA 1ASTA 2DW0A 1BQQM 4FXYP 3LQBA 3MA2A 1CGFA 2RJPA 3KMCA 1RM8A 2XS4A 3K7NA 2CKIA 1BZSA 3OHOA 1OM8A 1HTDA 3B2ZA 3KMEA 1Z3JA 1XUDA 4GWNA 1PWWA 3DPFA 1GE6A 5D1TA 1FM1A 1H71P 4GWMA 1GO7P 3ZUKA 2OW0A 1CQRA 3F1AA 3KECA 3I7GA 3OHLA 3F17A 1KUFA 1OO9A 2MLSA 3EDGA 3SHIA 3HBVP 2WO9A 1Q3AA 1G4KA 1I76A 3HYGA 4Q1LA 1D8FA 1QJIA 4A7BA 3LILA 2DDYA 2E3XA 1OS9A 1G49A 4GR0A 2OY4A
chains in the Genus database with same CATH superfamily
1G12A 2O36A 2RJQA 4FVLA 2W12A 4G0DA 1WNIA 2O3EA 1B8YA 1G05A 5BOTA 1IAGA 5CXAA 5D1UA 1BQOA 1R1JA 2MZIA 3LJTA 3ZXHA 4PKVA 1AKLA 2X7MA 5D3CA 3Q2HA 2SRTA 2V4BA 1B3DA 1UMSA 1R55A 2YUFA 2D1NA 3WV1A 1Y0VA 2JNPA 5BOYA 3F16A 4AUOA 1XURA 830CA 4PKTA 1YQYA 2N8RA 3EDIA 2A8HA 3TVCA 3F18A 4JPAA 4IN9A 4H84A 1GKCA 2YIGA 3EDZA 4PKSA 1PWVA 3E8RA 3EHYA 2OVXA 1HV5A 1UTTA 1A85A 4HMAA 3DSLA 1JAPA 4R3VA 4L19A 4A3WA 3LIKA 1GO8P 5BPAA 4PKWA 1XFUA 1ROSA 2I47A 1OM7A 3AYUA 3ELMA 1XM5A 1CGLA 4AXQA 2X3BA 1C3IA 2Y6CA 456CA 3EDHA 4WKEA 3TS4A 1Y93A 3LJZA 5D7WA 4DD8A 2POJA 4GR8A 1ZXCA 1TVIA 1SU3A 3AIGA 4H82A 2FV9A 1UMTA 1D8MA 1OMJA 2EROA 3NX7A 5I0LA 1S4BP 1SATA 1SLNA 1HOVA 1JIWP 2JT6A 4CTHA 1K7GA 5I4OA 1BM6A 2TCLA 3CKIA 3Q2GA 4XCTA 4XBHA 1UEAA 4H49A 3BA0A 1BKCA 3EWJA 3KHIA 1ZP5A 3LEAA 3ZVSA 2OW2A 3I7IA 3USNA 3G42A 2Y6DA 4J4MA 3N2UA 1J7NA 4XM8A 3DPEA 2JIHA 5L79A 2OXZA 1OM6A 1HFSA 1PWQA 5L7FA 1KUKA 4PKRA 3K7LA 5JMYA 4I03A 1C8TA 1HFCA 4GR3A 1DTHA 3HY9A 1CAQA 3P1VA 4ZR5A 5D1SA 2Z2DA 5H8XA 4JP4A 4JIJA 3HDAP 5I12A 3HBUP 2DDFA 1KUGA 3L0TA 5CUHA 1JAQA 2OI0A 1EB6A 1MMBA 1XAXA 3HDBA 1XFZA 4DV8A 2L0RA 1IAAA 4L63A 1GXDA 3RTSA 1QUAA 1ZS0A 4AIGA 1XFVA 2MZEA 2OXUA 4PKQA 1CK7A 1XFXA 2W14A 2W15A 3RTTA 1EUBA 2AIGP 1KUIA 1R54A 4ILWD 3LUMA 1BUVM 2W0DA 1FBLA 1FLSA 4IJOA 2WO8A 4XM7A 4WZVA 3B92A 4FU4A 3DL1A 1KBCA 1QIBA 1SMPA 5B5OA 4GQLA 3LQ0A 2FV5A 2K2GA 5I43A 3DTIA 4L6TA 4DF9A 1KUHA 5B5PA 1XFWA 2CLTA 966CA 4JA1A 4AYKA 1BIWA 2XS3A 1ZXVA 1I73A 1IABA 3P24A 1D7XA 3VTGA 2OXWA 1ND1A 3VI1A 1QICA 3N2VA 2X3AA 4QKZA 1AF0A 5LABA 3EHXA 1JJ9A 3DTKA 2OY2A 2KRJA 1ZTQA 2AYKA 5D2BA 1UTZA 5CZMA 1I1IP 3LKAA 1K7QA 3LK8A 2OW9A 1IACA 4G9LA 3LIRA 1R1HA 1YCMA 1JIZA 3LGPA 4WK7A 1HY7A 1JANA 1O0QA 1O0TA 1QIAA 1GE5A 4GF1A 1SLMA 3DTEA 1KAPP 1MMPA 1YOUA 5I2ZA 4H76A 1GE7A 2DW2A 1PWPA 1D5JA 4DPEA 2DW1A 3F19A 1PWUA 1RMZA 1BSWA 1MMQA 2D1OA 3DNGA 2MZHA 1JH1A 2QPJA 1YP1A 1ATLA 2PJTA 4H30A 3WV3A 4ON1A 5I3MA 4GUYA 1CGEA 4PKUA 3HB2P 1CXVA 3KRYA 4EFSA 3O2XA 4JQGA 4L7AA 3UVCA 1A86A 1JAOA 1MNCA 3KWVC 3U1RA 2W13A 3LUNA 4H1QA 3B8ZA 1GKDA 4H3XA 2ERPA 4I35A 1DMTA 2JT5A 1AYKA 2ERQA 4WF6A 1XUCA 3F15A 1CIZA 1EAKA 2WOAA 1BUDA 3LMCA 4WKIA 2OZRA 1IADA 3LE9A 1C7KA 1BKCI 2HU6A 4IUWA 3KEJA 3O64A 2J0TA 2OW1A 3WV2A 3HY7A 3KEKA 2X3CA 4FXQA 1ZVXA 1Y8JA 1R1IA 3G5CA 1OS2A 2OVZA 2YB9A 1QJJA 1USNA 4HX3A 2K9CA 1BKCE 2J83A 2MLRA 3TSKA 4XM6A 3LJGA 3TT4A 1G9KA 3V96B 1MMRA 2JSDA 1IAEA 2USNA 3DWBA 1JK3A 1XFYA 3L0VA 1L6JA 1JKYA 1SRPA 2E2DA 3AYKA 4H2EA 3GBOA 1K7IA 1ASTA 2DW0A 1BQQM 4FXYP 3LQBA 3MA2A 1CGFA 2RJPA 3KMCA 1RM8A 2XS4A 3K7NA 2CKIA 1BZSA 3OHOA 1OM8A 1HTDA 3B2ZA 3KMEA 1Z3JA 1XUDA 4GWNA 1PWWA 3DPFA 1GE6A 5D1TA 1FM1A 1H71P 4GWMA 1GO7P 3ZUKA 2OW0A 1CQRA 3F1AA 3KECA 3I7GA 3OHLA 3F17A 1KUFA 1OO9A 2MLSA 3EDGA 3SHIA 3HBVP 2WO9A 1Q3AA 1G4KA 1I76A 3HYGA 4Q1LA 1D8FA 1QJIA 1OZ9A 4A7BA 3LILA 2DDYA 2E3XA 1OS9A 1G49A 4GR0A 2OY4A
chains in the Genus database with same CATH topology
1G12A 2O36A 2RJQA 4FVLA 2W12A 4G0DA 1WNIA 2O3EA 1B8YA 1G05A 5BOTA 1IAGA 5CXAA 5D1UA 1BQOA 1R1JA 2MZIA 3LJTA 3ZXHA 4PKVA 1AKLA 2X7MA 5D3CA 3Q2HA 2SRTA 2V4BA 1B3DA 1UMSA 1R55A 2YUFA 2D1NA 3WV1A 1Y0VA 2JNPA 5BOYA 3F16A 4AUOA 1XURA 830CA 4PKTA 1YQYA 2N8RA 3EDIA 2A8HA 3TVCA 3F18A 4JPAA 4IN9A 4H84A 1GKCA 2YIGA 3EDZA 4PKSA 1PWVA 3E8RA 3EHYA 2OVXA 1HV5A 1UTTA 1A85A 4HMAA 3DSLA 1JAPA 4R3VA 4L19A 4A3WA 3LIKA 1GO8P 5BPAA 4PKWA 1XFUA 1ROSA 2I47A 1OM7A 3AYUA 3ELMA 1CGLA 4AXQA 2X3BA 1C3IA 2Y6CA 456CA 3EDHA 4WKEA 3TS4A 1Y93A 3LJZA 5D7WA 4DD8A 2POJA 4GR8A 1ZXCA 1SU3A 3AIGA 4H82A 2FV9A 1UMTA 1D8MA 1OMJA 2EROA 3NX7A 5I0LA 1S4BP 1SATA 1SLNA 1HOVA 1JIWP 2JT6A 4CTHA 1K7GA 5I4OA 1BM6A 2TCLA 3CKIA 3Q2GA 4XCTA 4XBHA 1UEAA 4H49A 3BA0A 1BKCA 3EWJA 3KHIA 1ZP5A 3LEAA 3ZVSA 2OW2A 3I7IA 3USNA 3G42A 2Y6DA 4J4MA 3N2UA 1J7NA 4XM8A 3DPEA 2JIHA 5L79A 2OXZA 1OM6A 1HFSA 1PWQA 5L7FA 1KUKA 4PKRA 3K7LA 5JMYA 4I03A 1C8TA 1HFCA 4GR3A 1DTHA 3HY9A 1CAQA 3P1VA 4ZR5A 5D1SA 2Z2DA 5H8XA 4JP4A 4JIJA 3HDAP 5I12A 3HBUP 2DDFA 1KUGA 3L0TA 5CUHA 1JAQA 2OI0A 1EB6A 1MMBA 3HDBA 1XFZA 4DV8A 2L0RA 1IAAA 4L63A 1GXDA 3RTSA 1QUAA 1ZS0A 4AIGA 1XFVA 2MZEA 2OXUA 4PKQA 1CK7A 1XFXA 2W14A 2W15A 3RTTA 1EUBA 2AIGP 1KUIA 1R54A 4ILWD 3LUMA 1BUVM 2W0DA 1FBLA 1FLSA 4IJOA 2WO8A 4XM7A 4WZVA 3B92A 4FU4A 3DL1A 1KBCA 1QIBA 1SMPA 5B5OA 4GQLA 3LQ0A 2FV5A 2K2GA 5I43A 3DTIA 4L6TA 4DF9A 1KUHA 5B5PA 1XFWA 2CLTA 966CA 4JA1A 4AYKA 1BIWA 2XS3A 1ZXVA 1I73A 1IABA 3P24A 1D7XA 3VTGA 2OXWA 1ND1A 3VI1A 1QICA 3N2VA 2X3AA 4QKZA 1AF0A 5LABA 3EHXA 1JJ9A 3DTKA 2OY2A 2KRJA 1ZTQA 2AYKA 5D2BA 1UTZA 5CZMA 1I1IP 3LKAA 1K7QA 3LK8A 2OW9A 1IACA 4G9LA 3LIRA 1R1HA 1YCMA 1JIZA 3LGPA 4WK7A 1HY7A 1JANA 1O0QA 1O0TA 1QIAA 1GE5A 4GF1A 1SLMA 3DTEA 1KAPP 1MMPA 1YOUA 5I2ZA 4H76A 1GE7A 2DW2A 1PWPA 1D5JA 4DPEA 2DW1A 3F19A 1PWUA 1RMZA 1BSWA 1MMQA 2D1OA 3DNGA 2MZHA 1JH1A 2QPJA 1YP1A 1ATLA 2PJTA 4H30A 3WV3A 4ON1A 5I3MA 4GUYA 1CGEA 4PKUA 3HB2P 1CXVA 3KRYA 4EFSA 3O2XA 4JQGA 4L7AA 3UVCA 1A86A 1JAOA 1MNCA 3KWVC 3U1RA 2W13A 3LUNA 4H1QA 3B8ZA 1GKDA 4H3XA 2ERPA 4I35A 1DMTA 2JT5A 1AYKA 2ERQA 4WF6A 1XUCA 3F15A 1CIZA 1EAKA 2WOAA 1BUDA 3LMCA 4WKIA 2OZRA 1IADA 3LE9A 1C7KA 1BKCI 2HU6A 4IUWA 3KEJA 3O64A 2J0TA 2OW1A 3WV2A 3HY7A 3KEKA 2X3CA 4FXQA 1ZVXA 1Y8JA 1R1IA 3G5CA 1OS2A 2OVZA 2YB9A 1QJJA 1USNA 4HX3A 2K9CA 1BKCE 2J83A 2MLRA 3TSKA 4XM6A 3LJGA 3TT4A 1G9KA 3V96B 1MMRA 2JSDA 1IAEA 2USNA 3DWBA 1JK3A 1XFYA 3L0VA 1L6JA 1JKYA 1SRPA 2E2DA 3AYKA 4H2EA 3GBOA 1K7IA 1ASTA 2DW0A 1BQQM 4FXYP 3LQBA 3MA2A 1CGFA 2RJPA 3KMCA 1RM8A 2XS4A 3K7NA 2CKIA 1BZSA 3OHOA 1OM8A 1HTDA 3B2ZA 3KMEA 1Z3JA 1XUDA 4GWNA 1PWWA 3DPFA 1GE6A 5D1TA 1FM1A 1H71P 4GWMA 1GO7P 3ZUKA 2OW0A 1CQRA 3F1AA 3KECA 3I7GA 3OHLA 3F17A 1KUFA 1OO9A 2MLSA 3EDGA 3SHIA 3HBVP 2WO9A 1Q3AA 1G4KA 1I76A 3HYGA 4Q1LA 1D8FA 1QJIA 4A7BA 3LILA 2DDYA 2E3XA 1OS9A 1G49A 4GR0A 2OY4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1G12 A;  2O36 A;  2RJQ A;  4FVL A;  2W12 A;  4G0D A;  1WNI A;  2O3E A;  1B8Y A;  1G05 A;  5BOT A;  1IAG A;  5CXA A;  5D1U A;  1BQO A;  1R1J A;  2MZI A;  3LJT A;  3ZXH A;  4PKV A;  1AKL A;  2X7M A;  5D3C A;  3Q2H A;  2SRT A;  2V4B A;  1B3D A;  1UMS A;  1R55 A;  2D1N A;  3WV1 A;  1Y0V A;  2JNP A;  5BOY A;  3F16 A;  4AUO A;  1XUR A;  830C A;  4PKT A;  1YQY A;  2N8R A;  3EDI A;  2A8H A;  3TVC A;  3F18 A;  4JPA A;  4IN9 A;  4H84 A;  1GKC A;  2YIG A;  3EDZ A;  4PKS A;  1PWV A;  3E8R A;  3EHY A;  2OVX A;  1HV5 A;  1UTT A;  1A85 A;  4HMA A;  3DSL A;  1JAP A;  4R3V A;  4L19 A;  4A3W A;  3LIK A;  1GO8 P;  5BPA A;  4PKW A;  1XFU A;  1ROS A;  2I47 A;  1OM7 A;  3AYU A;  3ELM A;  1CGL A;  4AXQ A;  2X3B A;  1C3I A;  2Y6C A;  456C A;  3EDH A;  4WKE A;  3TS4 A;  1Y93 A;  3LJZ A;  5D7W A;  4DD8 A;  2POJ A;  4GR8 A;  1ZXC A;  1SU3 A;  3AIG A;  4H82 A;  2FV9 A;  1UMT A;  1D8M A;  1OMJ A;  2ERO A;  3NX7 A;  5I0L A;  1S4B P;  1SAT A;  1SLN A;  1HOV A;  1JIW P;  2JT6 A;  4CTH A;  1K7G A;  5I4O A;  1BM6 A;  2TCL A;  3CKI A;  3Q2G A;  4XCT A;  4XBH A;  1UEA A;  4H49 A;  3BA0 A;  1BKC A;  3EWJ A;  3KHI A;  1ZP5 A;  3LEA A;  3ZVS A;  2OW2 A;  3I7I A;  3USN A;  3G42 A;  2Y6D A;  4J4M A;  3N2U A;  1J7N A;  4XM8 A;  3DPE A;  2JIH A;  5L79 A;  2OXZ A;  1OM6 A;  1HFS A;  1PWQ A;  5L7F A;  1KUK A;  4PKR A;  3K7L A;  5JMY A;  4I03 A;  1C8T A;  1HFC A;  4GR3 A;  1DTH A;  3HY9 A;  1CAQ A;  3P1V A;  4ZR5 A;  5D1S A;  2Z2D A;  5H8X A;  4JP4 A;  4JIJ A;  3HDA P;  5I12 A;  3HBU P;  2DDF A;  1KUG A;  3L0T A;  5CUH A;  1JAQ A;  2OI0 A;  1EB6 A;  1MMB A;  3HDB A;  1XFZ A;  4DV8 A;  2L0R A;  1IAA A;  4L63 A;  1GXD A;  3RTS A;  1QUA A;  1ZS0 A;  4AIG A;  1XFV A;  2MZE A;  2OXU A;  4PKQ A;  1CK7 A;  1XFX A;  2W14 A;  2W15 A;  3RTT A;  1EUB A;  2AIG P;  1KUI A;  1R54 A;  4ILW D;  3LUM A;  1BUV M;  2W0D A;  1FBL A;  1FLS A;  4IJO A;  2WO8 A;  4XM7 A;  4WZV A;  3B92 A;  4FU4 A;  3DL1 A;  1KBC A;  1QIB A;  1SMP A;  5B5O A;  4GQL A;  3LQ0 A;  2FV5 A;  2K2G A;  5I43 A;  4L6T A;  4DF9 A;  1KUH A;  5B5P A;  1XFW A;  2CLT A;  966C A;  4JA1 A;  4AYK A;  1BIW A;  2XS3 A;  1ZXV A;  1I73 A;  1IAB A;  3P24 A;  1D7X A;  3VTG A;  2OXW A;  1ND1 A;  3VI1 A;  1QIC A;  3N2V A;  2X3A A;  4QKZ A;  1AF0 A;  5LAB A;  3EHX A;  1JJ9 A;  2OY2 A;  2KRJ A;  1ZTQ A;  2AYK A;  5D2B A;  1UTZ A;  5CZM A;  1I1I P;  3LKA A;  1K7Q A;  3LK8 A;  2OW9 A;  1IAC A;  4G9L A;  3LIR A;  1R1H A;  1YCM A;  1JIZ A;  3LGP A;  4WK7 A;  1HY7 A;  1JAN A;  1O0Q A;  1O0T A;  1QIA A;  1GE5 A;  4GF1 A;  1SLM A;  1KAP P;  1MMP A;  1YOU A;  5I2Z A;  4H76 A;  1GE7 A;  2DW2 A;  1PWP A;  1D5J A;  4DPE A;  2DW1 A;  3F19 A;  1PWU A;  1RMZ A;  1BSW A;  1MMQ A;  2D1O A;  3DNG A;  2MZH A;  1JH1 A;  2QPJ A;  1YP1 A;  1ATL A;  2PJT A;  4H30 A;  3WV3 A;  4ON1 A;  5I3M A;  4GUY A;  1CGE A;  4PKU A;  3HB2 P;  1CXV A;  3KRY A;  4EFS A;  3O2X A;  4JQG A;  3UVC A;  1A86 A;  1JAO A;  1MNC A;  3KWV C;  3U1R A;  2W13 A;  3LUN A;  4H1Q A;  3B8Z A;  1GKD A;  4H3X A;  2ERP A;  4I35 A;  1DMT A;  2JT5 A;  1AYK A;  2ERQ A;  4WF6 A;  1XUC A;  3F15 A;  1CIZ A;  1EAK A;  2WOA A;  1BUD A;  3LMC A;  4WKI A;  2OZR A;  1IAD A;  3LE9 A;  1C7K A;  1BKC I;  2HU6 A;  4IUW A;  3KEJ A;  3O64 A;  2J0T A;  2OW1 A;  3WV2 A;  3HY7 A;  3KEK A;  2X3C A;  4FXQ A;  1ZVX A;  1Y8J A;  1R1I A;  3G5C A;  1OS2 A;  2OVZ A;  2YB9 A;  1QJJ A;  1USN A;  4HX3 A;  2K9C A;  1BKC E;  2J83 A;  2MLR A;  3TSK A;  4XM6 A;  3LJG A;  3TT4 A;  1G9K A;  3V96 B;  1MMR A;  2JSD A;  1IAE A;  2USN A;  3DWB A;  1JK3 A;  1XFY A;  3L0V A;  1L6J A;  1JKY A;  1SRP A;  2E2D A;  3AYK A;  4H2E A;  3GBO A;  1K7I A;  1AST A;  2DW0 A;  1BQQ M;  4FXY P;  3LQB A;  3MA2 A;  1CGF A;  2RJP A;  3KMC A;  1RM8 A;  2XS4 A;  3K7N A;  2CKI A;  1BZS A;  3OHO A;  1OM8 A;  1HTD A;  3B2Z A;  3KME A;  1Z3J A;  1XUD A;  4GWN A;  1PWW A;  3DPF A;  1GE6 A;  5D1T A;  1FM1 A;  1H71 P;  4GWM A;  1GO7 P;  3ZUK A;  2OW0 A;  1CQR A;  3F1A A;  3KEC A;  3I7G A;  3OHL A;  3F17 A;  1KUF A;  1OO9 A;  2MLS A;  3EDG A;  3SHI A;  3HBV P;  2WO9 A;  1Q3A A;  1G4K A;  1I76 A;  3HYG A;  4Q1L A;  1D8F A;  1QJI A;  4A7B A;  3LIL A;  2DDY A;  2E3X A;  1OS9 A;  1G49 A;  4GR0 A;  2OY4 A; 
#chains in the Genus database with same CATH topology
 1G12 A;  2O36 A;  2RJQ A;  4FVL A;  2W12 A;  4G0D A;  1WNI A;  2O3E A;  1B8Y A;  1G05 A;  5BOT A;  1IAG A;  5CXA A;  5D1U A;  1BQO A;  1R1J A;  2MZI A;  3LJT A;  3ZXH A;  4PKV A;  1AKL A;  2X7M A;  5D3C A;  3Q2H A;  2SRT A;  2V4B A;  1B3D A;  1UMS A;  1R55 A;  2YUF A;  2D1N A;  3WV1 A;  1Y0V A;  2JNP A;  5BOY A;  3F16 A;  4AUO A;  1XUR A;  830C A;  4PKT A;  1YQY A;  2N8R A;  3EDI A;  2A8H A;  3TVC A;  3F18 A;  4JPA A;  4IN9 A;  4H84 A;  1GKC A;  2YIG A;  3EDZ A;  4PKS A;  1PWV A;  3E8R A;  3EHY A;  2OVX A;  1HV5 A;  1UTT A;  1A85 A;  4HMA A;  3DSL A;  1JAP A;  4R3V A;  4L19 A;  4A3W A;  3LIK A;  1GO8 P;  5BPA A;  4PKW A;  1XFU A;  1ROS A;  2I47 A;  1OM7 A;  3AYU A;  3ELM A;  1XM5 A;  1CGL A;  4AXQ A;  2X3B A;  1C3I A;  2Y6C A;  456C A;  3EDH A;  4WKE A;  3TS4 A;  1Y93 A;  3LJZ A;  5D7W A;  4DD8 A;  2POJ A;  4GR8 A;  1ZXC A;  1TVI A;  1SU3 A;  3AIG A;  4H82 A;  2FV9 A;  1UMT A;  1D8M A;  1OMJ A;  2ERO A;  3NX7 A;  5I0L A;  1S4B P;  1SAT A;  1SLN A;  1HOV A;  1JIW P;  2JT6 A;  4CTH A;  1K7G A;  5I4O A;  1BM6 A;  2TCL A;  3CKI A;  3Q2G A;  4XCT A;  4XBH A;  1UEA A;  4H49 A;  3BA0 A;  1BKC A;  3EWJ A;  3KHI A;  1ZP5 A;  3LEA A;  3ZVS A;  2OW2 A;  3I7I A;  3USN A;  3G42 A;  2Y6D A;  4J4M A;  3N2U A;  1J7N A;  4XM8 A;  3DPE A;  2JIH A;  5L79 A;  2OXZ A;  1OM6 A;  1HFS A;  1PWQ A;  5L7F A;  1KUK A;  4PKR A;  3K7L A;  5JMY A;  4I03 A;  1C8T A;  1HFC A;  4GR3 A;  1DTH A;  3HY9 A;  1CAQ A;  3P1V A;  4ZR5 A;  5D1S A;  2Z2D A;  5H8X A;  4JP4 A;  4JIJ A;  3HDA P;  5I12 A;  3HBU P;  2DDF A;  1KUG A;  3L0T A;  5CUH A;  1JAQ A;  2OI0 A;  1EB6 A;  1MMB A;  1XAX A;  3HDB A;  1XFZ A;  4DV8 A;  2L0R A;  1IAA A;  4L63 A;  1GXD A;  3RTS A;  1QUA A;  1ZS0 A;  4AIG A;  1XFV A;  2MZE A;  2OXU A;  4PKQ A;  1CK7 A;  1XFX A;  2W14 A;  2W15 A;  3RTT A;  1EUB A;  2AIG P;  1KUI A;  1R54 A;  4ILW D;  3LUM A;  1BUV M;  2W0D A;  1FBL A;  1FLS A;  4IJO A;  2WO8 A;  4XM7 A;  4WZV A;  3B92 A;  4FU4 A;  3DL1 A;  1KBC A;  1QIB A;  1SMP A;  5B5O A;  4GQL A;  3LQ0 A;  2FV5 A;  2K2G A;  5I43 A;  3DTI A;  4L6T A;  4DF9 A;  1KUH A;  5B5P A;  1XFW A;  2CLT A;  966C A;  4JA1 A;  4AYK A;  1BIW A;  2XS3 A;  1ZXV A;  1I73 A;  1IAB A;  3P24 A;  1D7X A;  3VTG A;  2OXW A;  1ND1 A;  3VI1 A;  1QIC A;  3N2V A;  2X3A A;  4QKZ A;  1AF0 A;  5LAB A;  3EHX A;  1JJ9 A;  3DTK A;  2OY2 A;  2KRJ A;  1ZTQ A;  2AYK A;  5D2B A;  1UTZ A;  5CZM A;  1I1I P;  3LKA A;  1K7Q A;  3LK8 A;  2OW9 A;  1IAC A;  4G9L A;  3LIR A;  1R1H A;  1YCM A;  1JIZ A;  3LGP A;  4WK7 A;  1HY7 A;  1JAN A;  1O0Q A;  1O0T A;  1QIA A;  1GE5 A;  4GF1 A;  1SLM A;  3DTE A;  1KAP P;  1MMP A;  1YOU A;  5I2Z A;  4H76 A;  1GE7 A;  2DW2 A;  1PWP A;  1D5J A;  4DPE A;  2DW1 A;  3F19 A;  1PWU A;  1RMZ A;  1BSW A;  1MMQ A;  2D1O A;  3DNG A;  2MZH A;  1JH1 A;  2QPJ A;  1YP1 A;  1ATL A;  2PJT A;  4H30 A;  3WV3 A;  4ON1 A;  5I3M A;  4GUY A;  1CGE A;  4PKU A;  3HB2 P;  1CXV A;  3KRY A;  4EFS A;  3O2X A;  4JQG A;  4L7A A;  3UVC A;  1A86 A;  1JAO A;  1MNC A;  3KWV C;  3U1R A;  2W13 A;  3LUN A;  4H1Q A;  3B8Z A;  1GKD A;  4H3X A;  2ERP A;  4I35 A;  1DMT A;  2JT5 A;  1AYK A;  2ERQ A;  4WF6 A;  1XUC A;  3F15 A;  1CIZ A;  1EAK A;  2WOA A;  1BUD A;  3LMC A;  4WKI A;  2OZR A;  1IAD A;  3LE9 A;  1C7K A;  1BKC I;  2HU6 A;  4IUW A;  3KEJ A;  3O64 A;  2J0T A;  2OW1 A;  3WV2 A;  3HY7 A;  3KEK A;  2X3C A;  4FXQ A;  1ZVX A;  1Y8J A;  1R1I A;  3G5C A;  1OS2 A;  2OVZ A;  2YB9 A;  1QJJ A;  1USN A;  4HX3 A;  2K9C A;  1BKC E;  2J83 A;  2MLR A;  3TSK A;  4XM6 A;  3LJG A;  3TT4 A;  1G9K A;  3V96 B;  1MMR A;  2JSD A;  1IAE A;  2USN A;  3DWB A;  1JK3 A;  1XFY A;  3L0V A;  1L6J A;  1JKY A;  1SRP A;  2E2D A;  3AYK A;  4H2E A;  3GBO A;  1K7I A;  1AST A;  2DW0 A;  1BQQ M;  4FXY P;  3LQB A;  3MA2 A;  1CGF A;  2RJP A;  3KMC A;  1RM8 A;  2XS4 A;  3K7N A;  2CKI A;  1BZS A;  3OHO A;  1OM8 A;  1HTD A;  3B2Z A;  3KME A;  1Z3J A;  1XUD A;  4GWN A;  1PWW A;  3DPF A;  1GE6 A;  5D1T A;  1FM1 A;  1H71 P;  4GWM A;  1GO7 P;  3ZUK A;  2OW0 A;  1CQR A;  3F1A A;  3KEC A;  3I7G A;  3OHL A;  3F17 A;  1KUF A;  1OO9 A;  2MLS A;  3EDG A;  3SHI A;  3HBV P;  2WO9 A;  1Q3A A;  1G4K A;  1I76 A;  3HYG A;  4Q1L A;  1D8F A;  1QJI A;  1OZ9 A;  4A7B A;  3LIL A;  2DDY A;  2E3X A;  1OS9 A;  1G49 A;  4GR0 A;  2OY4 A; 
#chains in the Genus database with same CATH homology
 1G12 A;  2O36 A;  2RJQ A;  4FVL A;  2W12 A;  4G0D A;  1WNI A;  2O3E A;  1B8Y A;  1G05 A;  5BOT A;  1IAG A;  5CXA A;  5D1U A;  1BQO A;  1R1J A;  2MZI A;  3LJT A;  3ZXH A;  4PKV A;  1AKL A;  2X7M A;  5D3C A;  3Q2H A;  2SRT A;  2V4B A;  1B3D A;  1UMS A;  1R55 A;  2YUF A;  2D1N A;  3WV1 A;  1Y0V A;  2JNP A;  5BOY A;  3F16 A;  4AUO A;  1XUR A;  830C A;  4PKT A;  1YQY A;  2N8R A;  3EDI A;  2A8H A;  3TVC A;  3F18 A;  4JPA A;  4IN9 A;  4H84 A;  1GKC A;  2YIG A;  3EDZ A;  4PKS A;  1PWV A;  3E8R A;  3EHY A;  2OVX A;  1HV5 A;  1UTT A;  1A85 A;  4HMA A;  3DSL A;  1JAP A;  4R3V A;  4L19 A;  4A3W A;  3LIK A;  1GO8 P;  5BPA A;  4PKW A;  1XFU A;  1ROS A;  2I47 A;  1OM7 A;  3AYU A;  3ELM A;  1CGL A;  4AXQ A;  2X3B A;  1C3I A;  2Y6C A;  456C A;  3EDH A;  4WKE A;  3TS4 A;  1Y93 A;  3LJZ A;  5D7W A;  4DD8 A;  2POJ A;  4GR8 A;  1ZXC A;  1SU3 A;  3AIG A;  4H82 A;  2FV9 A;  1UMT A;  1D8M A;  1OMJ A;  2ERO A;  3NX7 A;  5I0L A;  1S4B P;  1SAT A;  1SLN A;  1HOV A;  1JIW P;  2JT6 A;  4CTH A;  1K7G A;  5I4O A;  1BM6 A;  2TCL A;  3CKI A;  3Q2G A;  4XCT A;  4XBH A;  1UEA A;  4H49 A;  3BA0 A;  1BKC A;  3EWJ A;  3KHI A;  1ZP5 A;  3LEA A;  3ZVS A;  2OW2 A;  3I7I A;  3USN A;  3G42 A;  2Y6D A;  4J4M A;  3N2U A;  1J7N A;  4XM8 A;  3DPE A;  2JIH A;  5L79 A;  2OXZ A;  1OM6 A;  1HFS A;  1PWQ A;  5L7F A;  1KUK A;  4PKR A;  3K7L A;  5JMY A;  4I03 A;  1C8T A;  1HFC A;  4GR3 A;  1DTH A;  3HY9 A;  1CAQ A;  3P1V A;  4ZR5 A;  5D1S A;  2Z2D A;  5H8X A;  4JP4 A;  4JIJ A;  3HDA P;  5I12 A;  3HBU P;  2DDF A;  1KUG A;  3L0T A;  5CUH A;  1JAQ A;  2OI0 A;  1EB6 A;  1MMB A;  3HDB A;  1XFZ A;  4DV8 A;  2L0R A;  1IAA A;  4L63 A;  1GXD A;  3RTS A;  1QUA A;  1ZS0 A;  4AIG A;  1XFV A;  2MZE A;  2OXU A;  4PKQ A;  1CK7 A;  1XFX A;  2W14 A;  2W15 A;  3RTT A;  1EUB A;  2AIG P;  1KUI A;  1R54 A;  4ILW D;  3LUM A;  1BUV M;  2W0D A;  1FBL A;  1FLS A;  4IJO A;  2WO8 A;  4XM7 A;  4WZV A;  3B92 A;  4FU4 A;  3DL1 A;  1KBC A;  1QIB A;  1SMP A;  5B5O A;  4GQL A;  3LQ0 A;  2FV5 A;  2K2G A;  5I43 A;  3DTI A;  4L6T A;  4DF9 A;  1KUH A;  5B5P A;  1XFW A;  2CLT A;  966C A;  4JA1 A;  4AYK A;  1BIW A;  2XS3 A;  1ZXV A;  1I73 A;  1IAB A;  3P24 A;  1D7X A;  3VTG A;  2OXW A;  1ND1 A;  3VI1 A;  1QIC A;  3N2V A;  2X3A A;  4QKZ A;  1AF0 A;  5LAB A;  3EHX A;  1JJ9 A;  3DTK A;  2OY2 A;  2KRJ A;  1ZTQ A;  2AYK A;  5D2B A;  1UTZ A;  5CZM A;  1I1I P;  3LKA A;  1K7Q A;  3LK8 A;  2OW9 A;  1IAC A;  4G9L A;  3LIR A;  1R1H A;  1YCM A;  1JIZ A;  3LGP A;  4WK7 A;  1HY7 A;  1JAN A;  1O0Q A;  1O0T A;  1QIA A;  1GE5 A;  4GF1 A;  1SLM A;  3DTE A;  1KAP P;  1MMP A;  1YOU A;  5I2Z A;  4H76 A;  1GE7 A;  2DW2 A;  1PWP A;  1D5J A;  4DPE A;  2DW1 A;  3F19 A;  1PWU A;  1RMZ A;  1BSW A;  1MMQ A;  2D1O A;  3DNG A;  2MZH A;  1JH1 A;  2QPJ A;  1YP1 A;  1ATL A;  2PJT A;  4H30 A;  3WV3 A;  4ON1 A;  5I3M A;  4GUY A;  1CGE A;  4PKU A;  3HB2 P;  1CXV A;  3KRY A;  4EFS A;  3O2X A;  4JQG A;  4L7A A;  3UVC A;  1A86 A;  1JAO A;  1MNC A;  3KWV C;  3U1R A;  2W13 A;  3LUN A;  4H1Q A;  3B8Z A;  1GKD A;  4H3X A;  2ERP A;  4I35 A;  1DMT A;  2JT5 A;  1AYK A;  2ERQ A;  4WF6 A;  1XUC A;  3F15 A;  1CIZ A;  1EAK A;  2WOA A;  1BUD A;  3LMC A;  4WKI A;  2OZR A;  1IAD A;  3LE9 A;  1C7K A;  1BKC I;  2HU6 A;  4IUW A;  3KEJ A;  3O64 A;  2J0T A;  2OW1 A;  3WV2 A;  3HY7 A;  3KEK A;  2X3C A;  4FXQ A;  1ZVX A;  1Y8J A;  1R1I A;  3G5C A;  1OS2 A;  2OVZ A;  2YB9 A;  1QJJ A;  1USN A;  4HX3 A;  2K9C A;  1BKC E;  2J83 A;  2MLR A;  3TSK A;  4XM6 A;  3LJG A;  3TT4 A;  1G9K A;  3V96 B;  1MMR A;  2JSD A;  1IAE A;  2USN A;  3DWB A;  1JK3 A;  1XFY A;  3L0V A;  1L6J A;  1JKY A;  1SRP A;  2E2D A;  3AYK A;  4H2E A;  3GBO A;  1K7I A;  1AST A;  2DW0 A;  1BQQ M;  4FXY P;  3LQB A;  3MA2 A;  1CGF A;  2RJP A;  3KMC A;  1RM8 A;  2XS4 A;  3K7N A;  2CKI A;  1BZS A;  3OHO A;  1OM8 A;  1HTD A;  3B2Z A;  3KME A;  1Z3J A;  1XUD A;  4GWN A;  1PWW A;  3DPF A;  1GE6 A;  5D1T A;  1FM1 A;  1H71 P;  4GWM A;  1GO7 P;  3ZUK A;  2OW0 A;  1CQR A;  3F1A A;  3KEC A;  3I7G A;  3OHL A;  3F17 A;  1KUF A;  1OO9 A;  2MLS A;  3EDG A;  3SHI A;  3HBV P;  2WO9 A;  1Q3A A;  1G4K A;  1I76 A;  3HYG A;  4Q1L A;  1D8F A;  1QJI A;  4A7B A;  3LIL A;  2DDY A;  2E3X A;  1OS9 A;  1G49 A;  4GR0 A;  2OY4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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