3E8RA

Crystal structure of catalytic domain of tace with hydroxamate inhibitor
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
257
structure length
251
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADAM 17
publication title Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 80
structure length 251
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2008-08-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3e8rA00
2AIGP 3B8ZA 1OS2A 4GR0A 5D2BA 1Y8JA 3HBUP 1Y0VA 2Y6CA 4PKSA 1UEAA 1GXDA 2OXUA 2X3CA 4FVLA 3RTTA 4PKQA 3LQ0A 2KRJA 2W12A 1EAKA 1MMBA 1PWVA 1I1IP 3LJZA 1BIWA 2MZIA 1D8FA 1CGLA 5L7FA 1GO7P 2E3XA 4GUYA 3EDZA 1AKLA 1HTDA 2FV9A 3HDBA 3BA0A 3P1VA 1KUKA 4WZVA 5BOTA 3KEJA 1SATA 1JAOA 2V4BA 3HBVP 3WV3A 1S4BP 1G4KA 4WK7A 1IACA 1XFYA 1ND1A 2OW1A 4WKEA 1CGFA 1JAQA 3L0VA 3F15A 1I73A 1OM6A 4I03A 1A86A 4JPAA 966CA 2K2GA 1MMRA 1ZVXA 1PWUA 2DW0A 2MZEA 1O0TA 1YQYA 1GO8P 4XCTA 1HFCA 3DWBA 1OMJA 1USNA 4CTHA 3HY9A 1YCMA 1KUGA 3N2UA 2DW2A 4FXYP 1PWQA 2JT6A 1KAPP 1BQQM 3WV1A 4AIGA 1YP1A 2X7MA 3E8RA 1BZSA 1OO9A 2RJPA 3HDAP 4H49A 5D3CA 5D1SA 2X3BA 3V96B 3SHIA 2JIHA 3LJGA 3B2ZA 4G0DA 3F17A 1QJIA 1RM8A 2Z2DA 1CK7A 4PKUA 5B5OA 2O3EA 4AYKA 1D7XA 4H82A 1L6JA 3RTSA 1FM1A 2XS3A 4DV8A 2E2DA 2OY2A 2I47A 2OVZA 2QPJA 3LQBA 4A7BA 4GF1A 3LIKA 2L0RA 1PWWA 3LEAA 2AYKA 1D5JA 3U1RA 3LK8A 2HU6A 2POJA 1IAEA 3LUNA 1CXVA 2FV5A 3G5CA 2TCLA 2OW2A 1ZS0A 4Q1LA 3Q2GA 2MLSA 1JANA 1CIZA 1GE5A 1HY7A 3EDGA 1JKYA 3USNA 1ROSA 1GKCA 4L63A 4GWMA 1I76A 3AYKA 4R3VA 2OW9A 2WOAA 1FBLA 3EWJA 1MNCA 5I43A 1KUFA 1QICA 1DMTA 2W13A 3ZXHA 5BPAA 1HFSA 1XFWA 3AYUA 5I3MA 1JIWP 3KMCA 4PKVA 1B8YA 1SRPA 1XFXA 1XFZA 2OY4A 2O36A 1K7IA 4GR8A 4IJOA 4ON1A 3HY7A 1JIZA 4IUWA 1C7KA 5I0LA 1Z3JA 1R54A 1ZXCA 4DD8A 2XS4A 1Y93A 4AUOA 1CGEA 3KHIA 3VTGA 4ZR5A 1BKCA 4PKTA 1BM6A 1AF0A 3O64A 1UTTA 2J83A 5LABA 3TT4A 3ZUKA 1AYKA 2DDFA 3EDIA 2A8HA 1BSWA 4XM8A 1G9KA 2ERPA 3DPFA 1SU3A 3I7IA 2W0DA 3GBOA 4GWNA 2OI0A 3WV2A 1MMPA 3KEKA 3KWVC 3F18A 2X3AA 4DPEA 4GQLA 3NX7A 4JQGA 1IAAA 1BQOA 2D1NA 1PWPA 1BKCI 1YOUA 1OM7A 4HMAA 3LILA 1OM8A 2WO8A 5I2ZA 3EDHA 1XFUA 3K7NA 1SMPA 1G05A 1IADA 1O0QA 2K9CA 4DF9A 2W14A 1XFVA 1K7GA 1RMZA 2JSDA 2W15A 456CA 1R1JA 1KUIA 2OVXA 5L79A 5CUHA 1QIBA 1BKCE 3LUMA 1R1HA 4GR3A 1EB6A 1JK3A 1G49A 2OZRA 1OS9A 1KBCA 2OW0A 1HV5A 1UMTA 3OHLA 5D1TA 3KECA 1HOVA 2SRTA 3L0TA 5D1UA 3VI1A 3CKIA 3TSKA 1EUBA 4JA1A 3EHYA 4PKRA 5CXAA 1DTHA 4JP4A 3I7GA 1ASTA 4H84A 1BUDA 3DNGA 2PJTA 4H3XA 2OXZA 4EFSA 2J0TA 3DSLA 1G12A 2MZHA 3MA2A 1ATLA 1WNIA 3N2VA 1JJ9A 1H71P 1A85A 4H30A 3TS4A 5CZMA 5I12A 5BOYA 1GE7A 4WKIA 2CKIA 1CAQA 3O2XA 1XURA 1ZTQA 2RJQA 1UMSA 1C3IA 5D7WA 4HX3A 5B5PA 3HB2P 1R55A 1D8MA 4I35A 3ELMA 3F16A 3DL1A 2USNA 4G9LA 3F19A 2N8RA 4L6TA 3ZVSA 3OHOA 4XBHA 4H1QA 4JIJA 1CQRA 3LGPA 1JAPA 2OXWA 2YIGA 4H76A 2EROA 3KRYA 1R1IA 1BUVM 4IN9A 4L19A 1UTZA 3UVCA 2ERQA 2JNPA 4XM6A 4XM7A 2MLRA 4WF6A 1ZXVA 2DW1A 4H2EA 1MMQA 3LKAA 4AXQA 3AIGA 3G42A 2Y6DA 1J7NA 2YB9A 2DDYA 1K7QA 1JH1A 3TVCA 1GKDA 4QKZA 1XUDA 5I4OA 4FU4A 5JMYA 1IABA 3B92A 3KMEA 2JT5A 5H8XA 1QJJA 1SLNA 1QUAA 2D1OA 3DPEA 1B3DA 3HYGA 3P24A 3LMCA 1QIAA 1C8TA 3EHXA 1GE6A 3LE9A 4FXQA 1IAGA 1FLSA 830CA 4A3WA 1KUHA 3LIRA 2WO9A 2CLTA 3LJTA 1Q3AA 1ZP5A 4ILWD 3Q2HA 1XUCA 1SLMA 4J4MA 4PKWA 3F1AA 3K7LA
chains in the Genus database with same CATH superfamily
2AIGP 3B8ZA 1OS2A 4GR0A 5D2BA 1Y8JA 3HBUP 1Y0VA 2Y6CA 4PKSA 1UEAA 1GXDA 2OXUA 2X3CA 4FVLA 3RTTA 4PKQA 3LQ0A 2KRJA 2W12A 1EAKA 1MMBA 1PWVA 1I1IP 3LJZA 1BIWA 2MZIA 1D8FA 1CGLA 5L7FA 1GO7P 2E3XA 4GUYA 3EDZA 1AKLA 1HTDA 2FV9A 3HDBA 3BA0A 3P1VA 1KUKA 4WZVA 5BOTA 3KEJA 1SATA 1JAOA 2V4BA 3HBVP 3WV3A 1S4BP 1G4KA 4WK7A 1IACA 1XFYA 1ND1A 2OW1A 1TVIA 4WKEA 1CGFA 1JAQA 1OZ9A 3L0VA 3F15A 1I73A 1OM6A 4I03A 1A86A 4JPAA 966CA 2K2GA 1MMRA 1ZVXA 1PWUA 2DW0A 2MZEA 1O0TA 3DTKA 1YQYA 1GO8P 4XCTA 1HFCA 3DWBA 1OMJA 1USNA 4CTHA 3HY9A 1YCMA 1KUGA 3N2UA 2DW2A 4FXYP 1PWQA 2JT6A 1KAPP 1BQQM 3WV1A 4AIGA 1YP1A 2X7MA 3E8RA 1BZSA 1OO9A 2RJPA 3HDAP 4H49A 5D3CA 5D1SA 1XM5A 2X3BA 3V96B 3SHIA 2JIHA 3LJGA 3B2ZA 4G0DA 3F17A 1QJIA 1RM8A 2Z2DA 1CK7A 4PKUA 5B5OA 2O3EA 4AYKA 4L7AA 1D7XA 4H82A 1L6JA 3RTSA 1FM1A 3DTIA 2XS3A 4DV8A 2E2DA 2OY2A 2I47A 2OVZA 2QPJA 3LQBA 4A7BA 4GF1A 3LIKA 2L0RA 1PWWA 3LEAA 2AYKA 1D5JA 3U1RA 3LK8A 2HU6A 2POJA 1IAEA 3LUNA 1CXVA 2FV5A 3G5CA 2TCLA 2OW2A 1ZS0A 4Q1LA 3Q2GA 2MLSA 1JANA 3DTEA 1CIZA 1GE5A 1HY7A 3EDGA 1JKYA 3USNA 1ROSA 1XAXA 1GKCA 4L63A 4GWMA 1I76A 3AYKA 4R3VA 2OW9A 2WOAA 1FBLA 3EWJA 1MNCA 5I43A 1KUFA 1QICA 1DMTA 2W13A 3ZXHA 5BPAA 1HFSA 1XFWA 3AYUA 5I3MA 1JIWP 3KMCA 4PKVA 1B8YA 1SRPA 1XFXA 1XFZA 2OY4A 2O36A 1K7IA 4GR8A 4IJOA 4ON1A 3HY7A 1JIZA 4IUWA 1C7KA 5I0LA 2YUFA 1Z3JA 1R54A 1ZXCA 4DD8A 2XS4A 1Y93A 4AUOA 1CGEA 3KHIA 3VTGA 4ZR5A 1BKCA 4PKTA 1BM6A 1AF0A 3O64A 1UTTA 2J83A 5LABA 3TT4A 3ZUKA 1AYKA 2DDFA 3EDIA 2A8HA 1BSWA 4XM8A 1G9KA 2ERPA 3DPFA 1SU3A 3I7IA 2W0DA 3GBOA 4GWNA 2OI0A 3WV2A 1MMPA 3KEKA 3KWVC 3F18A 2X3AA 4DPEA 4GQLA 3NX7A 4JQGA 1IAAA 1BQOA 2D1NA 1PWPA 1BKCI 1YOUA 1OM7A 4HMAA 3LILA 1OM8A 2WO8A 5I2ZA 3EDHA 1XFUA 3K7NA 1SMPA 1G05A 1IADA 1O0QA 2K9CA 4DF9A 2W14A 1XFVA 1K7GA 1RMZA 2JSDA 2W15A 456CA 1R1JA 1KUIA 2OVXA 5L79A 5CUHA 1QIBA 1BKCE 3LUMA 1R1HA 4GR3A 1EB6A 1JK3A 1G49A 2OZRA 1OS9A 1KBCA 2OW0A 1HV5A 1UMTA 3OHLA 5D1TA 3KECA 1HOVA 2SRTA 3L0TA 5D1UA 3VI1A 3CKIA 3TSKA 1EUBA 4JA1A 3EHYA 4PKRA 5CXAA 1DTHA 4JP4A 3I7GA 1ASTA 4H84A 1BUDA 3DNGA 2PJTA 4H3XA 2OXZA 4EFSA 2J0TA 3DSLA 1G12A 2MZHA 3MA2A 1ATLA 1WNIA 3N2VA 1JJ9A 1H71P 1A85A 4H30A 3TS4A 5CZMA 5I12A 5BOYA 1GE7A 4WKIA 2CKIA 1CAQA 3O2XA 1XURA 1ZTQA 2RJQA 1UMSA 1C3IA 5D7WA 4HX3A 5B5PA 3HB2P 1R55A 1D8MA 4I35A 3ELMA 3F16A 3DL1A 2USNA 4G9LA 3F19A 2N8RA 4L6TA 3ZVSA 3OHOA 4XBHA 4H1QA 4JIJA 1CQRA 3LGPA 1JAPA 2OXWA 2YIGA 4H76A 2EROA 3KRYA 1R1IA 1BUVM 4IN9A 4L19A 1UTZA 3UVCA 2ERQA 2JNPA 4XM6A 4XM7A 2MLRA 4WF6A 1ZXVA 2DW1A 4H2EA 1MMQA 3LKAA 4AXQA 3AIGA 3G42A 2Y6DA 1J7NA 2YB9A 2DDYA 1K7QA 1JH1A 3TVCA 1GKDA 4QKZA 1XUDA 5I4OA 4FU4A 5JMYA 1IABA 3B92A 3KMEA 2JT5A 5H8XA 1QJJA 1SLNA 1QUAA 2D1OA 3DPEA 1B3DA 3HYGA 3P24A 3LMCA 1QIAA 1C8TA 3EHXA 1GE6A 3LE9A 4FXQA 1IAGA 1FLSA 830CA 4A3WA 1KUHA 3LIRA 2WO9A 2CLTA 3LJTA 1Q3AA 1ZP5A 4ILWD 3Q2HA 1XUCA 1SLMA 4J4MA 4PKWA 3F1AA 3K7LA
chains in the Genus database with same CATH topology
2AIGP 3B8ZA 1OS2A 4GR0A 5D2BA 1Y8JA 3HBUP 1Y0VA 2Y6CA 4PKSA 1UEAA 1GXDA 2OXUA 2X3CA 4FVLA 3RTTA 4PKQA 3LQ0A 2KRJA 2W12A 1EAKA 1MMBA 1PWVA 1I1IP 3LJZA 1BIWA 2MZIA 1D8FA 1CGLA 5L7FA 1GO7P 2E3XA 4GUYA 3EDZA 1AKLA 1HTDA 2FV9A 3HDBA 3BA0A 3P1VA 1KUKA 4WZVA 5BOTA 3KEJA 1SATA 1JAOA 2V4BA 3HBVP 3WV3A 1S4BP 1G4KA 4WK7A 1IACA 1XFYA 1ND1A 2OW1A 4WKEA 1CGFA 1JAQA 3L0VA 3F15A 1I73A 1OM6A 4I03A 1A86A 4JPAA 966CA 2K2GA 1MMRA 1ZVXA 1PWUA 2DW0A 2MZEA 1O0TA 3DTKA 1YQYA 1GO8P 4XCTA 1HFCA 3DWBA 1OMJA 1USNA 4CTHA 3HY9A 1YCMA 1KUGA 3N2UA 2DW2A 4FXYP 1PWQA 2JT6A 1KAPP 1BQQM 3WV1A 4AIGA 1YP1A 2X7MA 3E8RA 1BZSA 1OO9A 2RJPA 3HDAP 4H49A 5D3CA 5D1SA 2X3BA 3V96B 3SHIA 2JIHA 3LJGA 3B2ZA 4G0DA 3F17A 1QJIA 1RM8A 2Z2DA 1CK7A 4PKUA 5B5OA 2O3EA 4AYKA 4L7AA 1D7XA 4H82A 1L6JA 3RTSA 1FM1A 3DTIA 2XS3A 4DV8A 2E2DA 2OY2A 2I47A 2OVZA 2QPJA 3LQBA 4A7BA 4GF1A 3LIKA 2L0RA 1PWWA 3LEAA 2AYKA 1D5JA 3U1RA 3LK8A 2HU6A 2POJA 1IAEA 3LUNA 1CXVA 2FV5A 3G5CA 2TCLA 2OW2A 1ZS0A 4Q1LA 3Q2GA 2MLSA 1JANA 3DTEA 1CIZA 1GE5A 1HY7A 3EDGA 1JKYA 3USNA 1ROSA 1GKCA 4L63A 4GWMA 1I76A 3AYKA 4R3VA 2OW9A 2WOAA 1FBLA 3EWJA 1MNCA 5I43A 1KUFA 1QICA 1DMTA 2W13A 3ZXHA 5BPAA 1HFSA 1XFWA 3AYUA 5I3MA 1JIWP 3KMCA 4PKVA 1B8YA 1SRPA 1XFXA 1XFZA 2OY4A 2O36A 1K7IA 4GR8A 4IJOA 4ON1A 3HY7A 1JIZA 4IUWA 1C7KA 5I0LA 2YUFA 1Z3JA 1R54A 1ZXCA 4DD8A 2XS4A 1Y93A 4AUOA 1CGEA 3KHIA 3VTGA 4ZR5A 1BKCA 4PKTA 1BM6A 1AF0A 3O64A 1UTTA 2J83A 5LABA 3TT4A 3ZUKA 1AYKA 2DDFA 3EDIA 2A8HA 1BSWA 4XM8A 1G9KA 2ERPA 3DPFA 1SU3A 3I7IA 2W0DA 3GBOA 4GWNA 2OI0A 3WV2A 1MMPA 3KEKA 3KWVC 3F18A 2X3AA 4DPEA 4GQLA 3NX7A 4JQGA 1IAAA 1BQOA 2D1NA 1PWPA 1BKCI 1YOUA 1OM7A 4HMAA 3LILA 1OM8A 2WO8A 5I2ZA 3EDHA 1XFUA 3K7NA 1SMPA 1G05A 1IADA 1O0QA 2K9CA 4DF9A 2W14A 1XFVA 1K7GA 1RMZA 2JSDA 2W15A 456CA 1R1JA 1KUIA 2OVXA 5L79A 5CUHA 1QIBA 1BKCE 3LUMA 1R1HA 4GR3A 1EB6A 1JK3A 1G49A 2OZRA 1OS9A 1KBCA 2OW0A 1HV5A 1UMTA 3OHLA 5D1TA 3KECA 1HOVA 2SRTA 3L0TA 5D1UA 3VI1A 3CKIA 3TSKA 1EUBA 4JA1A 3EHYA 4PKRA 5CXAA 1DTHA 4JP4A 3I7GA 1ASTA 4H84A 1BUDA 3DNGA 2PJTA 4H3XA 2OXZA 4EFSA 2J0TA 3DSLA 1G12A 2MZHA 3MA2A 1ATLA 1WNIA 3N2VA 1JJ9A 1H71P 1A85A 4H30A 3TS4A 5CZMA 5I12A 5BOYA 1GE7A 4WKIA 2CKIA 1CAQA 3O2XA 1XURA 1ZTQA 2RJQA 1UMSA 1C3IA 5D7WA 4HX3A 5B5PA 3HB2P 1R55A 1D8MA 4I35A 3ELMA 3F16A 3DL1A 2USNA 4G9LA 3F19A 2N8RA 4L6TA 3ZVSA 3OHOA 4XBHA 4H1QA 4JIJA 1CQRA 3LGPA 1JAPA 2OXWA 2YIGA 4H76A 2EROA 3KRYA 1R1IA 1BUVM 4IN9A 4L19A 1UTZA 3UVCA 2ERQA 2JNPA 4XM6A 4XM7A 2MLRA 4WF6A 1ZXVA 2DW1A 4H2EA 1MMQA 3LKAA 4AXQA 3AIGA 3G42A 2Y6DA 1J7NA 2YB9A 2DDYA 1K7QA 1JH1A 3TVCA 1GKDA 4QKZA 1XUDA 5I4OA 4FU4A 5JMYA 1IABA 3B92A 3KMEA 2JT5A 5H8XA 1QJJA 1SLNA 1QUAA 2D1OA 3DPEA 1B3DA 3HYGA 3P24A 3LMCA 1QIAA 1C8TA 3EHXA 1GE6A 3LE9A 4FXQA 1IAGA 1FLSA 830CA 4A3WA 1KUHA 3LIRA 2WO9A 2CLTA 3LJTA 1Q3AA 1ZP5A 4ILWD 3Q2HA 1XUCA 1SLMA 4J4MA 4PKWA 3F1AA 3K7LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2AIG P;  3B8Z A;  1OS2 A;  4GR0 A;  5D2B A;  1Y8J A;  3HBU P;  1Y0V A;  2Y6C A;  4PKS A;  1UEA A;  1GXD A;  2OXU A;  2X3C A;  4FVL A;  3RTT A;  4PKQ A;  3LQ0 A;  2KRJ A;  2W12 A;  1EAK A;  1MMB A;  1PWV A;  1I1I P;  3LJZ A;  1BIW A;  2MZI A;  1D8F A;  1CGL A;  5L7F A;  1GO7 P;  2E3X A;  4GUY A;  3EDZ A;  1AKL A;  1HTD A;  2FV9 A;  3HDB A;  3BA0 A;  3P1V A;  1KUK A;  4WZV A;  5BOT A;  3KEJ A;  1SAT A;  1JAO A;  2V4B A;  3HBV P;  3WV3 A;  1S4B P;  1G4K A;  4WK7 A;  1IAC A;  1XFY A;  1ND1 A;  2OW1 A;  4WKE A;  1CGF A;  1JAQ A;  3L0V A;  3F15 A;  1I73 A;  1OM6 A;  4I03 A;  1A86 A;  4JPA A;  966C A;  2K2G A;  1MMR A;  1ZVX A;  1PWU A;  2DW0 A;  2MZE A;  1O0T A;  1YQY A;  1GO8 P;  4XCT A;  1HFC A;  3DWB A;  1OMJ A;  1USN A;  4CTH A;  3HY9 A;  1YCM A;  1KUG A;  3N2U A;  2DW2 A;  4FXY P;  1PWQ A;  2JT6 A;  1KAP P;  1BQQ M;  3WV1 A;  4AIG A;  1YP1 A;  2X7M A;  3E8R A;  1BZS A;  1OO9 A;  2RJP A;  3HDA P;  4H49 A;  5D3C A;  5D1S A;  2X3B A;  3V96 B;  3SHI A;  2JIH A;  3LJG A;  3B2Z A;  4G0D A;  3F17 A;  1QJI A;  1RM8 A;  2Z2D A;  1CK7 A;  4PKU A;  5B5O A;  2O3E A;  4AYK A;  1D7X A;  4H82 A;  1L6J A;  3RTS A;  1FM1 A;  2XS3 A;  4DV8 A;  2E2D A;  2OY2 A;  2I47 A;  2OVZ A;  2QPJ A;  3LQB A;  4A7B A;  4GF1 A;  3LIK A;  2L0R A;  1PWW A;  3LEA A;  2AYK A;  1D5J A;  3U1R A;  3LK8 A;  2HU6 A;  2POJ A;  1IAE A;  3LUN A;  1CXV A;  2FV5 A;  3G5C A;  2TCL A;  2OW2 A;  1ZS0 A;  4Q1L A;  3Q2G A;  2MLS A;  1JAN A;  1CIZ A;  1GE5 A;  1HY7 A;  3EDG A;  1JKY A;  3USN A;  1ROS A;  1GKC A;  4L63 A;  4GWM A;  1I76 A;  3AYK A;  4R3V A;  2OW9 A;  2WOA A;  1FBL A;  3EWJ A;  1MNC A;  5I43 A;  1KUF A;  1QIC A;  1DMT A;  2W13 A;  3ZXH A;  5BPA A;  1HFS A;  1XFW A;  3AYU A;  5I3M A;  1JIW P;  3KMC A;  4PKV A;  1B8Y A;  1SRP A;  1XFX A;  1XFZ A;  2OY4 A;  2O36 A;  1K7I A;  4GR8 A;  4IJO A;  4ON1 A;  3HY7 A;  1JIZ A;  4IUW A;  1C7K A;  5I0L A;  1Z3J A;  1R54 A;  1ZXC A;  4DD8 A;  2XS4 A;  1Y93 A;  4AUO A;  1CGE A;  3KHI A;  3VTG A;  4ZR5 A;  1BKC A;  4PKT A;  1BM6 A;  1AF0 A;  3O64 A;  1UTT A;  2J83 A;  5LAB A;  3TT4 A;  3ZUK A;  1AYK A;  2DDF A;  3EDI A;  2A8H A;  1BSW A;  4XM8 A;  1G9K A;  2ERP A;  3DPF A;  1SU3 A;  3I7I A;  2W0D A;  3GBO A;  4GWN A;  2OI0 A;  3WV2 A;  1MMP A;  3KEK A;  3KWV C;  3F18 A;  2X3A A;  4DPE A;  4GQL A;  3NX7 A;  4JQG A;  1IAA A;  1BQO A;  2D1N A;  1PWP A;  1BKC I;  1YOU A;  1OM7 A;  4HMA A;  3LIL A;  1OM8 A;  2WO8 A;  5I2Z A;  3EDH A;  1XFU A;  3K7N A;  1SMP A;  1G05 A;  1IAD A;  1O0Q A;  2K9C A;  4DF9 A;  2W14 A;  1XFV A;  1K7G A;  1RMZ A;  2JSD A;  2W15 A;  456C A;  1R1J A;  1KUI A;  2OVX A;  5L79 A;  5CUH A;  1QIB A;  1BKC E;  3LUM A;  1R1H A;  4GR3 A;  1EB6 A;  1JK3 A;  1G49 A;  2OZR A;  1OS9 A;  1KBC A;  2OW0 A;  1HV5 A;  1UMT A;  3OHL A;  5D1T A;  3KEC A;  1HOV A;  2SRT A;  3L0T A;  5D1U A;  3VI1 A;  3CKI A;  3TSK A;  1EUB A;  4JA1 A;  3EHY A;  4PKR A;  5CXA A;  1DTH A;  4JP4 A;  3I7G A;  1AST A;  4H84 A;  1BUD A;  3DNG A;  2PJT A;  4H3X A;  2OXZ A;  4EFS A;  2J0T A;  3DSL A;  1G12 A;  2MZH A;  3MA2 A;  1ATL A;  1WNI A;  3N2V A;  1JJ9 A;  1H71 P;  1A85 A;  4H30 A;  3TS4 A;  5CZM A;  5I12 A;  5BOY A;  1GE7 A;  4WKI A;  2CKI A;  1CAQ A;  3O2X A;  1XUR A;  1ZTQ A;  2RJQ A;  1UMS A;  1C3I A;  5D7W A;  4HX3 A;  5B5P A;  3HB2 P;  1R55 A;  1D8M A;  4I35 A;  3ELM A;  3F16 A;  3DL1 A;  2USN A;  4G9L A;  3F19 A;  2N8R A;  4L6T A;  3ZVS A;  3OHO A;  4XBH A;  4H1Q A;  4JIJ A;  1CQR A;  3LGP A;  1JAP A;  2OXW A;  2YIG A;  4H76 A;  2ERO A;  3KRY A;  1R1I A;  1BUV M;  4IN9 A;  4L19 A;  1UTZ A;  3UVC A;  2ERQ A;  2JNP A;  4XM6 A;  4XM7 A;  2MLR A;  4WF6 A;  1ZXV A;  2DW1 A;  4H2E A;  1MMQ A;  3LKA A;  4AXQ A;  3AIG A;  3G42 A;  2Y6D A;  1J7N A;  2YB9 A;  2DDY A;  1K7Q A;  1JH1 A;  3TVC A;  1GKD A;  4QKZ A;  1XUD A;  5I4O A;  4FU4 A;  5JMY A;  1IAB A;  3B92 A;  3KME A;  2JT5 A;  5H8X A;  1QJJ A;  1SLN A;  1QUA A;  2D1O A;  3DPE A;  1B3D A;  3HYG A;  3P24 A;  3LMC A;  1QIA A;  1C8T A;  3EHX A;  1GE6 A;  3LE9 A;  4FXQ A;  1IAG A;  1FLS A;  830C A;  4A3W A;  1KUH A;  3LIR A;  2WO9 A;  2CLT A;  3LJT A;  1Q3A A;  1ZP5 A;  4ILW D;  3Q2H A;  1XUC A;  1SLM A;  4J4M A;  4PKW A;  3F1A A;  3K7L A; 
#chains in the Genus database with same CATH topology
 2AIG P;  3B8Z A;  1OS2 A;  4GR0 A;  5D2B A;  1Y8J A;  3HBU P;  1Y0V A;  2Y6C A;  4PKS A;  1UEA A;  1GXD A;  2OXU A;  2X3C A;  4FVL A;  3RTT A;  4PKQ A;  3LQ0 A;  2KRJ A;  2W12 A;  1EAK A;  1MMB A;  1PWV A;  1I1I P;  3LJZ A;  1BIW A;  2MZI A;  1D8F A;  1CGL A;  5L7F A;  1GO7 P;  2E3X A;  4GUY A;  3EDZ A;  1AKL A;  1HTD A;  2FV9 A;  3HDB A;  3BA0 A;  3P1V A;  1KUK A;  4WZV A;  5BOT A;  3KEJ A;  1SAT A;  1JAO A;  2V4B A;  3HBV P;  3WV3 A;  1S4B P;  1G4K A;  4WK7 A;  1IAC A;  1XFY A;  1ND1 A;  2OW1 A;  1TVI A;  4WKE A;  1CGF A;  1JAQ A;  1OZ9 A;  3L0V A;  3F15 A;  1I73 A;  1OM6 A;  4I03 A;  1A86 A;  4JPA A;  966C A;  2K2G A;  1MMR A;  1ZVX A;  1PWU A;  2DW0 A;  2MZE A;  1O0T A;  3DTK A;  1YQY A;  1GO8 P;  4XCT A;  1HFC A;  3DWB A;  1OMJ A;  1USN A;  4CTH A;  3HY9 A;  1YCM A;  1KUG A;  3N2U A;  2DW2 A;  4FXY P;  1PWQ A;  2JT6 A;  1KAP P;  1BQQ M;  3WV1 A;  4AIG A;  1YP1 A;  2X7M A;  3E8R A;  1BZS A;  1OO9 A;  2RJP A;  3HDA P;  4H49 A;  5D3C A;  5D1S A;  1XM5 A;  2X3B A;  3V96 B;  3SHI A;  2JIH A;  3LJG A;  3B2Z A;  4G0D A;  3F17 A;  1QJI A;  1RM8 A;  2Z2D A;  1CK7 A;  4PKU A;  5B5O A;  2O3E A;  4AYK A;  4L7A A;  1D7X A;  4H82 A;  1L6J A;  3RTS A;  1FM1 A;  3DTI A;  2XS3 A;  4DV8 A;  2E2D A;  2OY2 A;  2I47 A;  2OVZ A;  2QPJ A;  3LQB A;  4A7B A;  4GF1 A;  3LIK A;  2L0R A;  1PWW A;  3LEA A;  2AYK A;  1D5J A;  3U1R A;  3LK8 A;  2HU6 A;  2POJ A;  1IAE A;  3LUN A;  1CXV A;  2FV5 A;  3G5C A;  2TCL A;  2OW2 A;  1ZS0 A;  4Q1L A;  3Q2G A;  2MLS A;  1JAN A;  3DTE A;  1CIZ A;  1GE5 A;  1HY7 A;  3EDG A;  1JKY A;  3USN A;  1ROS A;  1XAX A;  1GKC A;  4L63 A;  4GWM A;  1I76 A;  3AYK A;  4R3V A;  2OW9 A;  2WOA A;  1FBL A;  3EWJ A;  1MNC A;  5I43 A;  1KUF A;  1QIC A;  1DMT A;  2W13 A;  3ZXH A;  5BPA A;  1HFS A;  1XFW A;  3AYU A;  5I3M A;  1JIW P;  3KMC A;  4PKV A;  1B8Y A;  1SRP A;  1XFX A;  1XFZ A;  2OY4 A;  2O36 A;  1K7I A;  4GR8 A;  4IJO A;  4ON1 A;  3HY7 A;  1JIZ A;  4IUW A;  1C7K A;  5I0L A;  2YUF A;  1Z3J A;  1R54 A;  1ZXC A;  4DD8 A;  2XS4 A;  1Y93 A;  4AUO A;  1CGE A;  3KHI A;  3VTG A;  4ZR5 A;  1BKC A;  4PKT A;  1BM6 A;  1AF0 A;  3O64 A;  1UTT A;  2J83 A;  5LAB A;  3TT4 A;  3ZUK A;  1AYK A;  2DDF A;  3EDI A;  2A8H A;  1BSW A;  4XM8 A;  1G9K A;  2ERP A;  3DPF A;  1SU3 A;  3I7I A;  2W0D A;  3GBO A;  4GWN A;  2OI0 A;  3WV2 A;  1MMP A;  3KEK A;  3KWV C;  3F18 A;  2X3A A;  4DPE A;  4GQL A;  3NX7 A;  4JQG A;  1IAA A;  1BQO A;  2D1N A;  1PWP A;  1BKC I;  1YOU A;  1OM7 A;  4HMA A;  3LIL A;  1OM8 A;  2WO8 A;  5I2Z A;  3EDH A;  1XFU A;  3K7N A;  1SMP A;  1G05 A;  1IAD A;  1O0Q A;  2K9C A;  4DF9 A;  2W14 A;  1XFV A;  1K7G A;  1RMZ A;  2JSD A;  2W15 A;  456C A;  1R1J A;  1KUI A;  2OVX A;  5L79 A;  5CUH A;  1QIB A;  1BKC E;  3LUM A;  1R1H A;  4GR3 A;  1EB6 A;  1JK3 A;  1G49 A;  2OZR A;  1OS9 A;  1KBC A;  2OW0 A;  1HV5 A;  1UMT A;  3OHL A;  5D1T A;  3KEC A;  1HOV A;  2SRT A;  3L0T A;  5D1U A;  3VI1 A;  3CKI A;  3TSK A;  1EUB A;  4JA1 A;  3EHY A;  4PKR A;  5CXA A;  1DTH A;  4JP4 A;  3I7G A;  1AST A;  4H84 A;  1BUD A;  3DNG A;  2PJT A;  4H3X A;  2OXZ A;  4EFS A;  2J0T A;  3DSL A;  1G12 A;  2MZH A;  3MA2 A;  1ATL A;  1WNI A;  3N2V A;  1JJ9 A;  1H71 P;  1A85 A;  4H30 A;  3TS4 A;  5CZM A;  5I12 A;  5BOY A;  1GE7 A;  4WKI A;  2CKI A;  1CAQ A;  3O2X A;  1XUR A;  1ZTQ A;  2RJQ A;  1UMS A;  1C3I A;  5D7W A;  4HX3 A;  5B5P A;  3HB2 P;  1R55 A;  1D8M A;  4I35 A;  3ELM A;  3F16 A;  3DL1 A;  2USN A;  4G9L A;  3F19 A;  2N8R A;  4L6T A;  3ZVS A;  3OHO A;  4XBH A;  4H1Q A;  4JIJ A;  1CQR A;  3LGP A;  1JAP A;  2OXW A;  2YIG A;  4H76 A;  2ERO A;  3KRY A;  1R1I A;  1BUV M;  4IN9 A;  4L19 A;  1UTZ A;  3UVC A;  2ERQ A;  2JNP A;  4XM6 A;  4XM7 A;  2MLR A;  4WF6 A;  1ZXV A;  2DW1 A;  4H2E A;  1MMQ A;  3LKA A;  4AXQ A;  3AIG A;  3G42 A;  2Y6D A;  1J7N A;  2YB9 A;  2DDY A;  1K7Q A;  1JH1 A;  3TVC A;  1GKD A;  4QKZ A;  1XUD A;  5I4O A;  4FU4 A;  5JMY A;  1IAB A;  3B92 A;  3KME A;  2JT5 A;  5H8X A;  1QJJ A;  1SLN A;  1QUA A;  2D1O A;  3DPE A;  1B3D A;  3HYG A;  3P24 A;  3LMC A;  1QIA A;  1C8T A;  3EHX A;  1GE6 A;  3LE9 A;  4FXQ A;  1IAG A;  1FLS A;  830C A;  4A3W A;  1KUH A;  3LIR A;  2WO9 A;  2CLT A;  3LJT A;  1Q3A A;  1ZP5 A;  4ILW D;  3Q2H A;  1XUC A;  1SLM A;  4J4M A;  4PKW A;  3F1A A;  3K7L A; 
#chains in the Genus database with same CATH homology
 2AIG P;  3B8Z A;  1OS2 A;  4GR0 A;  5D2B A;  1Y8J A;  3HBU P;  1Y0V A;  2Y6C A;  4PKS A;  1UEA A;  1GXD A;  2OXU A;  2X3C A;  4FVL A;  3RTT A;  4PKQ A;  3LQ0 A;  2KRJ A;  2W12 A;  1EAK A;  1MMB A;  1PWV A;  1I1I P;  3LJZ A;  1BIW A;  2MZI A;  1D8F A;  1CGL A;  5L7F A;  1GO7 P;  2E3X A;  4GUY A;  3EDZ A;  1AKL A;  1HTD A;  2FV9 A;  3HDB A;  3BA0 A;  3P1V A;  1KUK A;  4WZV A;  5BOT A;  3KEJ A;  1SAT A;  1JAO A;  2V4B A;  3HBV P;  3WV3 A;  1S4B P;  1G4K A;  4WK7 A;  1IAC A;  1XFY A;  1ND1 A;  2OW1 A;  4WKE A;  1CGF A;  1JAQ A;  3L0V A;  3F15 A;  1I73 A;  1OM6 A;  4I03 A;  1A86 A;  4JPA A;  966C A;  2K2G A;  1MMR A;  1ZVX A;  1PWU A;  2DW0 A;  2MZE A;  1O0T A;  3DTK A;  1YQY A;  1GO8 P;  4XCT A;  1HFC A;  3DWB A;  1OMJ A;  1USN A;  4CTH A;  3HY9 A;  1YCM A;  1KUG A;  3N2U A;  2DW2 A;  4FXY P;  1PWQ A;  2JT6 A;  1KAP P;  1BQQ M;  3WV1 A;  4AIG A;  1YP1 A;  2X7M A;  3E8R A;  1BZS A;  1OO9 A;  2RJP A;  3HDA P;  4H49 A;  5D3C A;  5D1S A;  2X3B A;  3V96 B;  3SHI A;  2JIH A;  3LJG A;  3B2Z A;  4G0D A;  3F17 A;  1QJI A;  1RM8 A;  2Z2D A;  1CK7 A;  4PKU A;  5B5O A;  2O3E A;  4AYK A;  4L7A A;  1D7X A;  4H82 A;  1L6J A;  3RTS A;  1FM1 A;  3DTI A;  2XS3 A;  4DV8 A;  2E2D A;  2OY2 A;  2I47 A;  2OVZ A;  2QPJ A;  3LQB A;  4A7B A;  4GF1 A;  3LIK A;  2L0R A;  1PWW A;  3LEA A;  2AYK A;  1D5J A;  3U1R A;  3LK8 A;  2HU6 A;  2POJ A;  1IAE A;  3LUN A;  1CXV A;  2FV5 A;  3G5C A;  2TCL A;  2OW2 A;  1ZS0 A;  4Q1L A;  3Q2G A;  2MLS A;  1JAN A;  3DTE A;  1CIZ A;  1GE5 A;  1HY7 A;  3EDG A;  1JKY A;  3USN A;  1ROS A;  1GKC A;  4L63 A;  4GWM A;  1I76 A;  3AYK A;  4R3V A;  2OW9 A;  2WOA A;  1FBL A;  3EWJ A;  1MNC A;  5I43 A;  1KUF A;  1QIC A;  1DMT A;  2W13 A;  3ZXH A;  5BPA A;  1HFS A;  1XFW A;  3AYU A;  5I3M A;  1JIW P;  3KMC A;  4PKV A;  1B8Y A;  1SRP A;  1XFX A;  1XFZ A;  2OY4 A;  2O36 A;  1K7I A;  4GR8 A;  4IJO A;  4ON1 A;  3HY7 A;  1JIZ A;  4IUW A;  1C7K A;  5I0L A;  2YUF A;  1Z3J A;  1R54 A;  1ZXC A;  4DD8 A;  2XS4 A;  1Y93 A;  4AUO A;  1CGE A;  3KHI A;  3VTG A;  4ZR5 A;  1BKC A;  4PKT A;  1BM6 A;  1AF0 A;  3O64 A;  1UTT A;  2J83 A;  5LAB A;  3TT4 A;  3ZUK A;  1AYK A;  2DDF A;  3EDI A;  2A8H A;  1BSW A;  4XM8 A;  1G9K A;  2ERP A;  3DPF A;  1SU3 A;  3I7I A;  2W0D A;  3GBO A;  4GWN A;  2OI0 A;  3WV2 A;  1MMP A;  3KEK A;  3KWV C;  3F18 A;  2X3A A;  4DPE A;  4GQL A;  3NX7 A;  4JQG A;  1IAA A;  1BQO A;  2D1N A;  1PWP A;  1BKC I;  1YOU A;  1OM7 A;  4HMA A;  3LIL A;  1OM8 A;  2WO8 A;  5I2Z A;  3EDH A;  1XFU A;  3K7N A;  1SMP A;  1G05 A;  1IAD A;  1O0Q A;  2K9C A;  4DF9 A;  2W14 A;  1XFV A;  1K7G A;  1RMZ A;  2JSD A;  2W15 A;  456C A;  1R1J A;  1KUI A;  2OVX A;  5L79 A;  5CUH A;  1QIB A;  1BKC E;  3LUM A;  1R1H A;  4GR3 A;  1EB6 A;  1JK3 A;  1G49 A;  2OZR A;  1OS9 A;  1KBC A;  2OW0 A;  1HV5 A;  1UMT A;  3OHL A;  5D1T A;  3KEC A;  1HOV A;  2SRT A;  3L0T A;  5D1U A;  3VI1 A;  3CKI A;  3TSK A;  1EUB A;  4JA1 A;  3EHY A;  4PKR A;  5CXA A;  1DTH A;  4JP4 A;  3I7G A;  1AST A;  4H84 A;  1BUD A;  3DNG A;  2PJT A;  4H3X A;  2OXZ A;  4EFS A;  2J0T A;  3DSL A;  1G12 A;  2MZH A;  3MA2 A;  1ATL A;  1WNI A;  3N2V A;  1JJ9 A;  1H71 P;  1A85 A;  4H30 A;  3TS4 A;  5CZM A;  5I12 A;  5BOY A;  1GE7 A;  4WKI A;  2CKI A;  1CAQ A;  3O2X A;  1XUR A;  1ZTQ A;  2RJQ A;  1UMS A;  1C3I A;  5D7W A;  4HX3 A;  5B5P A;  3HB2 P;  1R55 A;  1D8M A;  4I35 A;  3ELM A;  3F16 A;  3DL1 A;  2USN A;  4G9L A;  3F19 A;  2N8R A;  4L6T A;  3ZVS A;  3OHO A;  4XBH A;  4H1Q A;  4JIJ A;  1CQR A;  3LGP A;  1JAP A;  2OXW A;  2YIG A;  4H76 A;  2ERO A;  3KRY A;  1R1I A;  1BUV M;  4IN9 A;  4L19 A;  1UTZ A;  3UVC A;  2ERQ A;  2JNP A;  4XM6 A;  4XM7 A;  2MLR A;  4WF6 A;  1ZXV A;  2DW1 A;  4H2E A;  1MMQ A;  3LKA A;  4AXQ A;  3AIG A;  3G42 A;  2Y6D A;  1J7N A;  2YB9 A;  2DDY A;  1K7Q A;  1JH1 A;  3TVC A;  1GKD A;  4QKZ A;  1XUD A;  5I4O A;  4FU4 A;  5JMY A;  1IAB A;  3B92 A;  3KME A;  2JT5 A;  5H8X A;  1QJJ A;  1SLN A;  1QUA A;  2D1O A;  3DPE A;  1B3D A;  3HYG A;  3P24 A;  3LMC A;  1QIA A;  1C8T A;  3EHX A;  1GE6 A;  3LE9 A;  4FXQ A;  1IAG A;  1FLS A;  830C A;  4A3W A;  1KUH A;  3LIR A;  2WO9 A;  2CLT A;  3LJT A;  1Q3A A;  1ZP5 A;  4ILW D;  3Q2H A;  1XUC A;  1SLM A;  4J4M A;  4PKW A;  3F1A A;  3K7L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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