3EPWA

Crystal structure of trypanosoma vivax nucleoside hydrolase in complex with the inhibitor (2r,3r,4s)-1-[(4-hydroxy-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-2-(hydroxymethyl)pyrrolidin-3,4-diol
Total Genus 114
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
114
sequence length
326
structure length
326
Chain Sequence
AKNVVLDHDGNLDDFVAMVLLASNTEKVRLIGALCTDADCFVENGFNVTGKIMCLMHNNMNLPLFPIGKSAATAVNPFPKEWRCLAKNMDDMPILNIPENVELWDKIKAENEKYEGQQLLADLVMNSEEKVTICVTGPLSNVAWCIDKYGEKFTSKVEECVIMGGAVDVRGNVFLPSTDGTAEWNIYWDPASAKTVFGCPGLRRIMFSLDSTNTVPVRSPYVQRFGEQTNFLLSILVGTMWAMCTHCELLRDGDGYYAWDALTAAYVVDQKVANVDPVPIDVVVDKQPNEGATVRTDAENYPLTFVARNPEAEFFLDMLLRSARAC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords IAG-nucleoside hydrolase
publication title Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors.
pubmed doi rcsb
source organism Trypanosoma vivax
total genus 114
structure length 326
sequence length 326
chains with identical sequence B
ec nomenclature ec 3.2.2.1: Purine nucleosidase.
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01156 IU_nuc_hydro Inosine-uridine preferring nucleoside hydrolase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.245.10 Alpha Beta Alpha-Beta Complex Inosine-uridine Nucleoside N-ribohydrolase; Chain A Ribonucleoside hydrolase-like 3epwA00
4I73A 3EPXA 2MASA 3MKMA 4I71A 4KPNA 2FF2A 4I75A 4KPOA 1KICA 1EZRA 3MKNA 4WR2A 4I70A 3FZ0A 3T8JA 1R4FA 2FF1A 3EPWA 3B9GA 3T8IA 2C40A 4I72A 1YOEA 4P5FA 1HP0A 1KIEA 3B9XA 1HOZA 1Q8FA 4KL0A 5TSQA 2YHGA 3G5IA 1MASA 4I74A
chains in the Genus database with same CATH superfamily
4I73A 3EPXA 2MASA 3MKMA 4I71A 4KPNA 2FF2A 4I75A 4KPOA 1KICA 1EZRA 3MKNA 4WR2A 4I70A 3FZ0A 3T8JA 1R4FA 2FF1A 3EPWA 3B9GA 3T8IA 2C40A 4I72A 1YOEA 4P5FA 1HP0A 1KIEA 3B9XA 1HOZA 1Q8FA 4KL0A 5TSQA 2YHGA 3G5IA 1MASA 4I74A
chains in the Genus database with same CATH topology
4I73A 3EPXA 2MASA 3MKMA 4I71A 4KPNA 2FF2A 4I75A 4KPOA 1KICA 1EZRA 3MKNA 4WR2A 4I70A 3FZ0A 3T8JA 1R4FA 2FF1A 3EPWA 3B9GA 3T8IA 2C40A 4I72A 1YOEA 4P5FA 1HP0A 1KIEA 3B9XA 1HOZA 1Q8FA 4KL0A 5TSQA 2YHGA 3G5IA 1MASA 4I74A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4I73 A;  3EPX A;  2MAS A;  3MKM A;  4I71 A;  4KPN A;  2FF2 A;  4I75 A;  4KPO A;  1KIC A;  1EZR A;  3MKN A;  4WR2 A;  4I70 A;  3FZ0 A;  3T8J A;  1R4F A;  2FF1 A;  3EPW A;  3B9G A;  3T8I A;  2C40 A;  4I72 A;  1YOE A;  4P5F A;  1HP0 A;  1KIE A;  3B9X A;  1HOZ A;  1Q8F A;  4KL0 A;  5TSQ A;  2YHG A;  3G5I A;  1MAS A;  4I74 A; 
#chains in the Genus database with same CATH topology
 4I73 A;  3EPX A;  2MAS A;  3MKM A;  4I71 A;  4KPN A;  2FF2 A;  4I75 A;  4KPO A;  1KIC A;  1EZR A;  3MKN A;  4WR2 A;  4I70 A;  3FZ0 A;  3T8J A;  1R4F A;  2FF1 A;  3EPW A;  3B9G A;  3T8I A;  2C40 A;  4I72 A;  1YOE A;  4P5F A;  1HP0 A;  1KIE A;  3B9X A;  1HOZ A;  1Q8F A;  4KL0 A;  5TSQ A;  2YHG A;  3G5I A;  1MAS A;  4I74 A; 
#chains in the Genus database with same CATH homology
 4I73 A;  3EPX A;  2MAS A;  3MKM A;  4I71 A;  4KPN A;  2FF2 A;  4I75 A;  4KPO A;  1KIC A;  1EZR A;  3MKN A;  4WR2 A;  4I70 A;  3FZ0 A;  3T8J A;  1R4F A;  2FF1 A;  3EPW A;  3B9G A;  3T8I A;  2C40 A;  4I72 A;  1YOE A;  4P5F A;  1HP0 A;  1KIE A;  3B9X A;  1HOZ A;  1Q8F A;  4KL0 A;  5TSQ A;  2YHG A;  3G5I A;  1MAS A;  4I74 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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