3F0RA

Crystal structure analysis of human hdac8 complexed with trichostatin a in a new monoclinic crystal form
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
366
structure length
364
Chain Sequence
SLVPVYIYSPEYVSMCDSLIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Histone deacetylase 8
publication title Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 123
structure length 364
sequence length 366
chains with identical sequence B, C
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2008-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3f0rA00
2V5XA 5A2SA 3EW8A 4QA3A 5EENA 5D1BA 5LI3A 3F07A 4QA6A 5IWGA 4QA1A 4BKXB 5EFGA 5G10A 4ZUNA 4CQFA 3ZNRA 5G17A 3C0ZA 4BZ8A 5G1AA 5G11A 5THTA 1T64A 2V5WA 4QA4A 4BZ6A 4ZUPA 4QA0A 3RQDA 4A69A 1ZZ1A 5EF7A 3EZTA 3MENA 4ZUQA 3C0YA 3SFHA 5G0XA 1VKGA 5EFKB 3ZNSA 4ZUOA 4RN0A 4QA5A 3EWFA 5EFJD 5FCWA 2VQOA 5EF8A 2VQJA 5G0GA 1C3SA 4LXZA 5DC8A 2VQWG 5THVA 3Q9FA 5EEMA 1C3RA 5FUEA 2VQMA 3F0RA 3MZ7A 5G12A 3MAXA 5DC6A 5G0JA 4BZ5A 4CBYA 5EEFA 2VCGA 3Q9BA 5G0HA 4LY1A 5D1DA 5DC5A 5EFBD 3SFFA 5EEIA 3MZ6A 5EFNA 4QA2A 1ZZ3A 4BZ9A 4RN1A 5D1CA 4ZUMA 4BZ7A 3Q9EA 3MZ4A 1W22A 5G0IA 5G0YA 5IX0A 5DC7A 1T69A 5THSA 3F06A 5G3WA 3EZPA 4CBTA 5EFHA 5JI5A 2VQVA 5G1BA 4RN2A 5EEKA 5ICNB 5BWZA 2VQQA 4QA7A 5G13A 3MZ3A 2GH6A 5G1CA 1C3PA 3C10A 1T67A 1ZZ0A 4ZURA 5THUA 3Q9CA
chains in the Genus database with same CATH superfamily
4GSZA 2V5XA 2PHOA 3EW8A 4QA3A 5EENA 5THUA 5A2SA 5D1BA 5LI3A 3F07A 4GSMA 4MXRA 4QA6A 5IWGA 4CEVA 4RHLA 4QA1A 4HZEA 4BKXB 1HQHA 5EFGA 4ZUNA 5G10A 1P8OA 4CQFA 3DJ8A 4IE1A 3THHA 3ZNRA 5G17A 3C0ZA 3SJTA 1T4RA 4IXVA 5G1AA 4BZ8A 4Q41A 1P8SA 4Q40A 4Q3TA 4MYFA 5G11A 5THTA 2ZAVA 4Q42A 1T64A 4ITYA 4RHQA 5HJAA 2V5WA 4QA4A 4BZ6A 4ZUPA 1CEVA 4QA0A 3RQDA 1ZZ1A 4IE3A 4A69A 3GN0A 3MMRA 3PZLA 5EF7A 1XFKA 3E9BA 3EZTA 3MENA 4Q3RA 1TBHA 4ZUQA 1TBJA 3C0YA 3SFHA 5G0XA 1VKGA 3LP4A 5EFKB 3M1RA 4G3HA 1GQ7A 2PLLA 5RLAA 3ZNSA 4MYNA 4ZUOA 4RN0A 3MFWA 1P8NA 4RHKA 4FCIA 1WOGA 4IXUA 3GMZA 4QA5A 3EWFA 3SKKA 4RHMA 1ZPGA 5EFJD 4GWCA 4Q3RC 4MYLA 3TF3A 2CEVA 1WVAA 5FCWA 1R1OA 2VQOA 5EF8A 3NIQA 2VQJA 1WVBA 1P8RA 4HXQA 1GQ6A 5G0GA 1C3SA 4Q3QA 4Q3VA 4LXZA 1T4SA 5DC8A 1WOIA 2VQWG 5THVA 4GSVA 3TH7A 3Q9FA 3THEA 5EEMA 1C3RA 4GWDA 5FUEA 1T5GA 2VQMA 4IE2A 3F0RA 4IU0A 3MZ7A 4MYKA 5G12A 3MAXA 5DC6A 4DZ4A 2RLAA 5G0JA 4FCKA 1P8QA 4BZ5A 4CBYA 5EEFA 2VCGA 2EF5A 1T4TA 3LHLA 3Q9BA 5G0HA 3RLAA 4IU1A 4LY1A 5D1DA 5DC5A 1D3VA 3LP7A 3SL1A 1TA1A 5EFBD 3KV2A 3THJA 3SFFA 5EEIA 3MZ6A 1HQXA 3E6KA 5EFNA 4QA2A 1ZZ3A 4BZ9A 1HQ5A 4RN1A 2A0MA 1WOHA 4HWWA 5D1CA 2AEBA 4ZUMA 3E8ZA 5HJ9A 4BZ7A 4Q3UA 3F80A 3Q9EA 3MZ4A 3NIPA 4Q3SA 1W22A 3SL0A 4IU4A 5G0IA 5G0YA 5IX0A 5DC7A 5CEVA 4I06A 4IU5A 1HQFA 4RHJA 1T69A 1ZPEA 5THSA 1TBLA 3F06A 5G3WA 3EZPA 4CBTA 4Q3PA 3E8QA 1P8MA 5EFHA 5JI5A 2VQVA 1T4PA 5G1BA 4RN2A 5EEKA 1HQGA 1RLAA 3E6VA 3NIOA 5ICNB 3MFVA 2EF4A 3MJLA 2VQQA 4QA7A 4RHIA 5G13A 5BWZA 1T5FA 3MZ3A 2EIVA 2GH6A 2PHAA 1C3PA 3C10A 1P8PA 1T67A 1ZZ0A 4ZURA 5G1CA 4RLAA 1PQ3A 3Q9CA 3CEVA
chains in the Genus database with same CATH topology
2V5XA 5A2SA 3EW8A 4QA3A 5EENA 5D1BA 5LI3A 3F07A 4QA6A 5IWGA 4QA1A 4BKXB 5EFGA 5G10A 4ZUNA 4CQFA 3ZNRA 5G17A 3C0ZA 4BZ8A 5G1AA 5G11A 5THTA 1T64A 2V5WA 4QA4A 4BZ6A 4ZUPA 4QA0A 3RQDA 4A69A 1ZZ1A 5EF7A 3EZTA 3MENA 4ZUQA 3C0YA 3SFHA 5G0XA 1VKGA 5EFKB 3ZNSA 4ZUOA 4RN0A 4QA5A 3EWFA 5EFJD 5FCWA 2VQOA 5EF8A 2VQJA 5G0GA 1C3SA 4LXZA 5DC8A 2VQWG 5THVA 3Q9FA 5EEMA 1C3RA 5FUEA 2VQMA 3F0RA 3MZ7A 5G12A 3MAXA 5DC6A 5G0JA 4BZ5A 4CBYA 5EEFA 2VCGA 3Q9BA 5G0HA 4LY1A 5D1DA 5DC5A 5EFBD 3SFFA 5EEIA 3MZ6A 5EFNA 4QA2A 1ZZ3A 4BZ9A 4RN1A 5D1CA 4ZUMA 4BZ7A 3Q9EA 3MZ4A 1W22A 5G0IA 5G0YA 5IX0A 5DC7A 1T69A 5THSA 3F06A 5G3WA 3EZPA 4CBTA 5EFHA 5JI5A 2VQVA 5G1BA 4RN2A 5EEKA 5ICNB 5BWZA 2VQQA 4QA7A 5G13A 3MZ3A 2GH6A 5G1CA 1C3PA 3C10A 1T67A 1ZZ0A 4ZURA 5THUA 3Q9CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V5X A;  5A2S A;  3EW8 A;  4QA3 A;  5EEN A;  5D1B A;  5LI3 A;  3F07 A;  4QA6 A;  5IWG A;  4QA1 A;  4BKX B;  5EFG A;  5G10 A;  4ZUN A;  4CQF A;  3ZNR A;  5G17 A;  3C0Z A;  4BZ8 A;  5G1A A;  5G11 A;  5THT A;  1T64 A;  2V5W A;  4QA4 A;  4BZ6 A;  4ZUP A;  4QA0 A;  3RQD A;  4A69 A;  1ZZ1 A;  5EF7 A;  3EZT A;  3MEN A;  4ZUQ A;  3C0Y A;  3SFH A;  5G0X A;  1VKG A;  5EFK B;  3ZNS A;  4ZUO A;  4RN0 A;  4QA5 A;  3EWF A;  5EFJ D;  5FCW A;  2VQO A;  5EF8 A;  2VQJ A;  5G0G A;  1C3S A;  4LXZ A;  5DC8 A;  2VQW G;  5THV A;  3Q9F A;  5EEM A;  1C3R A;  5FUE A;  2VQM A;  3F0R A;  3MZ7 A;  5G12 A;  3MAX A;  5DC6 A;  5G0J A;  4BZ5 A;  4CBY A;  5EEF A;  2VCG A;  3Q9B A;  5G0H A;  4LY1 A;  5D1D A;  5DC5 A;  5EFB D;  3SFF A;  5EEI A;  3MZ6 A;  5EFN A;  4QA2 A;  1ZZ3 A;  4BZ9 A;  4RN1 A;  5D1C A;  4ZUM A;  4BZ7 A;  3Q9E A;  3MZ4 A;  1W22 A;  5G0I A;  5G0Y A;  5IX0 A;  5DC7 A;  1T69 A;  5THS A;  3F06 A;  5G3W A;  3EZP A;  4CBT A;  5EFH A;  5JI5 A;  2VQV A;  5G1B A;  4RN2 A;  5EEK A;  5ICN B;  5BWZ A;  2VQQ A;  4QA7 A;  5G13 A;  3MZ3 A;  2GH6 A;  5G1C A;  1C3P A;  3C10 A;  1T67 A;  1ZZ0 A;  4ZUR A;  5THU A;  3Q9C A; 
#chains in the Genus database with same CATH topology
 4GSZ A;  2V5X A;  2PHO A;  3EW8 A;  4QA3 A;  5EEN A;  5THU A;  5A2S A;  5D1B A;  5LI3 A;  3F07 A;  4GSM A;  4MXR A;  4QA6 A;  5IWG A;  4CEV A;  4RHL A;  4QA1 A;  4HZE A;  4BKX B;  1HQH A;  5EFG A;  4ZUN A;  5G10 A;  1P8O A;  4CQF A;  3DJ8 A;  4IE1 A;  3THH A;  3ZNR A;  5G17 A;  3C0Z A;  3SJT A;  1T4R A;  4IXV A;  5G1A A;  4BZ8 A;  4Q41 A;  1P8S A;  4Q40 A;  4Q3T A;  4MYF A;  5G11 A;  5THT A;  2ZAV A;  4Q42 A;  1T64 A;  4ITY A;  4RHQ A;  5HJA A;  2V5W A;  4QA4 A;  4BZ6 A;  4ZUP A;  1CEV A;  4QA0 A;  3RQD A;  1ZZ1 A;  4IE3 A;  4A69 A;  3GN0 A;  3MMR A;  3PZL A;  5EF7 A;  1XFK A;  3E9B A;  3EZT A;  3MEN A;  4Q3R A;  1TBH A;  4ZUQ A;  1TBJ A;  3C0Y A;  3SFH A;  5G0X A;  1VKG A;  3LP4 A;  5EFK B;  3M1R A;  4G3H A;  1GQ7 A;  2PLL A;  5RLA A;  3ZNS A;  4MYN A;  4ZUO A;  4RN0 A;  3MFW A;  1P8N A;  4RHK A;  4FCI A;  1WOG A;  4IXU A;  3GMZ A;  4QA5 A;  3EWF A;  3SKK A;  4RHM A;  1ZPG A;  5EFJ D;  4GWC A;  4Q3R C;  4MYL A;  3TF3 A;  2CEV A;  1WVA A;  5FCW A;  1R1O A;  2VQO A;  5EF8 A;  3NIQ A;  2VQJ A;  1WVB A;  1P8R A;  4HXQ A;  1GQ6 A;  5G0G A;  1C3S A;  4Q3Q A;  4Q3V A;  4LXZ A;  1T4S A;  5DC8 A;  1WOI A;  2VQW G;  5THV A;  4GSV A;  3TH7 A;  3Q9F A;  3THE A;  5EEM A;  1C3R A;  4GWD A;  5FUE A;  1T5G A;  2VQM A;  4IE2 A;  3F0R A;  4IU0 A;  3MZ7 A;  4MYK A;  5G12 A;  3MAX A;  5DC6 A;  4DZ4 A;  2RLA A;  5G0J A;  4FCK A;  1P8Q A;  4BZ5 A;  4CBY A;  5EEF A;  2VCG A;  2EF5 A;  1T4T A;  3LHL A;  3Q9B A;  5G0H A;  3RLA A;  4IU1 A;  4LY1 A;  5D1D A;  5DC5 A;  1D3V A;  3LP7 A;  3SL1 A;  1TA1 A;  5EFB D;  3KV2 A;  3THJ A;  3SFF A;  5EEI A;  3MZ6 A;  1HQX A;  3E6K A;  5EFN A;  4QA2 A;  1ZZ3 A;  4BZ9 A;  1HQ5 A;  4RN1 A;  2A0M A;  1WOH A;  4HWW A;  5D1C A;  2AEB A;  4ZUM A;  3E8Z A;  5HJ9 A;  4BZ7 A;  4Q3U A;  3F80 A;  3Q9E A;  3MZ4 A;  3NIP A;  4Q3S A;  1W22 A;  3SL0 A;  4IU4 A;  5G0I A;  5G0Y A;  5IX0 A;  5DC7 A;  5CEV A;  4I06 A;  4IU5 A;  1HQF A;  4RHJ A;  1T69 A;  1ZPE A;  5THS A;  1TBL A;  3F06 A;  5G3W A;  3EZP A;  4CBT A;  4Q3P A;  3E8Q A;  1P8M A;  5EFH A;  5JI5 A;  2VQV A;  1T4P A;  5G1B A;  4RN2 A;  5EEK A;  1HQG A;  1RLA A;  3E6V A;  3NIO A;  5ICN B;  3MFV A;  2EF4 A;  3MJL A;  2VQQ A;  4QA7 A;  4RHI A;  5G13 A;  5BWZ A;  1T5F A;  3MZ3 A;  2EIV A;  2GH6 A;  2PHA A;  1C3P A;  3C10 A;  1P8P A;  1T67 A;  1ZZ0 A;  4ZUR A;  5G1C A;  4RLA A;  1PQ3 A;  3Q9C A;  3CEV A; 
#chains in the Genus database with same CATH homology
 2V5X A;  5A2S A;  3EW8 A;  4QA3 A;  5EEN A;  5D1B A;  5LI3 A;  3F07 A;  4QA6 A;  5IWG A;  4QA1 A;  4BKX B;  5EFG A;  5G10 A;  4ZUN A;  4CQF A;  3ZNR A;  5G17 A;  3C0Z A;  4BZ8 A;  5G1A A;  5G11 A;  5THT A;  1T64 A;  2V5W A;  4QA4 A;  4BZ6 A;  4ZUP A;  4QA0 A;  3RQD A;  4A69 A;  1ZZ1 A;  5EF7 A;  3EZT A;  3MEN A;  4ZUQ A;  3C0Y A;  3SFH A;  5G0X A;  1VKG A;  5EFK B;  3ZNS A;  4ZUO A;  4RN0 A;  4QA5 A;  3EWF A;  5EFJ D;  5FCW A;  2VQO A;  5EF8 A;  2VQJ A;  5G0G A;  1C3S A;  4LXZ A;  5DC8 A;  2VQW G;  5THV A;  3Q9F A;  5EEM A;  1C3R A;  5FUE A;  2VQM A;  3F0R A;  3MZ7 A;  5G12 A;  3MAX A;  5DC6 A;  5G0J A;  4BZ5 A;  4CBY A;  5EEF A;  2VCG A;  3Q9B A;  5G0H A;  4LY1 A;  5D1D A;  5DC5 A;  5EFB D;  3SFF A;  5EEI A;  3MZ6 A;  5EFN A;  4QA2 A;  1ZZ3 A;  4BZ9 A;  4RN1 A;  5D1C A;  4ZUM A;  4BZ7 A;  3Q9E A;  3MZ4 A;  1W22 A;  5G0I A;  5G0Y A;  5IX0 A;  5DC7 A;  1T69 A;  5THS A;  3F06 A;  5G3W A;  3EZP A;  4CBT A;  5EFH A;  5JI5 A;  2VQV A;  5G1B A;  4RN2 A;  5EEK A;  5ICN B;  5BWZ A;  2VQQ A;  4QA7 A;  5G13 A;  3MZ3 A;  2GH6 A;  5G1C A;  1C3P A;  3C10 A;  1T67 A;  1ZZ0 A;  4ZUR A;  5THU A;  3Q9C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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