3FFKA

Crystal structure of human gelsolin domains g1-g3 bound to actin
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
347
structure length
347
Chain Sequence
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Structural protein
molecule keywords plasma gelsolin
total genus 105
structure length 347
sequence length 347
chains with identical sequence D
ec nomenclature
pdb deposition date 2008-12-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 3ffkA02
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 3ffkA01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 3ffkA03
1M2VA 1YAGG 1NMDG 1DEJS 1D0NA 2NUTB 2VILA 1F7SA 3CJBG 1VFQA 1COFA 5KYWA 4S10C 3EGXB 2VACA 4PKIG 1P8ZG 1Q8GA 3CJCG 1KCQA 1V6FA 1P8XA 2QTVA 1Q8XA 3FG6A 5KYYA 5KYUB 4LIZA 3EG9B 3FFKA 2HD7A 5HVKD 3Q2BA 2FF6G 1T3YA 1AK7A 2FH3A 2D8BA 1EQYS 2LXXA 5KYUA 3EGDA 1AHQA 2MOTA 3EG9A 1C0FS 5HVKB 1H1VG 1M2VB 1PD1A 3A5OS 2LJ8A 1WNJA 5A1MA 3L50A 1MDUA 1J72A 1RGIG 1SVYA 3A5NS 3DAWB 4BEX1 2KVKA 2FGHA 2I2QA 3EGDB 1NPHA 1VKKA 2XF1A 5KYNA 1SVRA 4KEDA 1AK6A 1X67A 3FG7A 1TMWA 1WFSA 5DD2A 5FAFA 1PCXA 2LLFA 5KYYB 2FH4A 1CFYA 1NM1G 3EFOA 3A5LS 3FFNA 2VIKA 1T3XA 2XFAA 2W0IA 2FH1A 1CNUA 1YVNG 2FF3A 5KYXA 4CBXG 3EFOB 1M2OA 4Z94G 4KEEA 2NUTA 4JD2H 1JHWA 1C0GS 5FAEA 3CI5G 5KYWB 2L72A 1D4XG 1T44G 3EGXA 2NUPB 5KYXB 1HQZ1 1TVJA 1PD0A 1WM4A 3TU5B 3EH2A 1QPVA 4PKGG 1ESVS 1NLVG 2NUPA 2MV2A 3CIPG 5L6WC 4KEFA 4PKHB 1UDMA 3A5MS 1M4JA 2MP4A 4CBWG 5IVUA 1T2LA 2FH2A 3EH1A 1SVQA 4CBUG
chains in the Genus database with same CATH superfamily
1M2VA 1YAGG 1NMDG 1DEJS 1D0NA 2NUTB 2VILA 1F7SA 3CJBG 1VFQA 1COFA 5KYWA 4S10C 3EGXB 2VACA 4PKIG 1P8ZG 1Q8GA 3CJCG 1KCQA 1V6FA 1P8XA 2QTVA 1Q8XA 3FG6A 5KYYA 5KYUB 4LIZA 3EG9B 3FFKA 2HD7A 5HVKD 3Q2BA 2FF6G 1T3YA 1AK7A 2FH3A 2D8BA 1EQYS 2LXXA 5KYUA 3EGDA 1AHQA 2MOTA 3EG9A 1C0FS 5HVKB 1H1VG 1M2VB 1PD1A 3A5OS 2LJ8A 1WNJA 5A1MA 3L50A 1MDUA 1J72A 1RGIG 1SVYA 3A5NS 3DAWB 4BEX1 2KVKA 2FGHA 2I2QA 3EGDB 1NPHA 1VKKA 2XF1A 5KYNA 1SVRA 4KEDA 1AK6A 1X67A 3FG7A 1TMWA 1WFSA 5DD2A 5FAFA 1PCXA 2LLFA 5KYYB 2FH4A 1CFYA 1NM1G 3EFOA 3A5LS 3FFNA 2VIKA 1T3XA 2XFAA 2W0IA 2FH1A 1CNUA 1YVNG 2FF3A 5KYXA 4CBXG 3DA7A 3EFOB 1M2OA 4Z94G 4KEEA 2NUTA 4JD2H 1JHWA 1C0GS 5FAEA 3CI5G 5KYWB 2L72A 1D4XG 1T44G 3EGXA 2NUPB 5KYXB 1HQZ1 1TVJA 1PD0A 1WM4A 3TU5B 3EH2A 1QPVA 4PKGG 1ESVS 1NLVG 2NUPA 2MV2A 3CIPG 5L6WC 4KEFA 4PKHB 1UDMA 3A5MS 1M4JA 2MP4A 4CBWG 5IVUA 1T2LA 2FH2A 3EH1A 1SVQA 4CBUG
chains in the Genus database with same CATH topology
1M2VA 1YAGG 1NMDG 1DEJS 1D0NA 2NUTB 2VILA 1F7SA 3CJBG 1VFQA 1COFA 5KYWA 4S10C 3EGXB 2VACA 4PKIG 1P8ZG 1Q8GA 3CJCG 1KCQA 1V6FA 1P8XA 2QTVA 1Q8XA 3FG6A 5KYYA 5KYUB 4LIZA 3EG9B 3FFKA 2HD7A 5HVKD 3Q2BA 2FF6G 1T3YA 1AK7A 2FH3A 2D8BA 1EQYS 2LXXA 5KYUA 3EGDA 1AHQA 2MOTA 3EG9A 1C0FS 5HVKB 1H1VG 1M2VB 1PD1A 3A5OS 2LJ8A 1WNJA 5A1MA 3L50A 1MDUA 1J72A 1RGIG 1SVYA 3A5NS 3DAWB 4BEX1 2KVKA 2FGHA 2I2QA 3EGDB 1NPHA 1VKKA 2XF1A 5KYNA 1SVRA 4KEDA 1AK6A 1X67A 3FG7A 1TMWA 1WFSA 5DD2A 5FAFA 1PCXA 2LLFA 5KYYB 2FH4A 1CFYA 1NM1G 3EFOA 3A5LS 3FFNA 2VIKA 1T3XA 2XFAA 2W0IA 2FH1A 1CNUA 1YVNG 2FF3A 5KYXA 4CBXG 3DA7A 3EFOB 1M2OA 4Z94G 4KEEA 2NUTA 4JD2H 1JHWA 1C0GS 5FAEA 3CI5G 5KYWB 2L72A 1D4XG 1T44G 3EGXA 2NUPB 5KYXB 1HQZ1 1TVJA 1PD0A 1WM4A 3TU5B 3EH2A 1QPVA 4PKGG 1ESVS 1NLVG 2NUPA 2MV2A 3CIPG 5L6WC 4KEFA 4PKHB 1UDMA 3A5MS 1M4JA 2MP4A 4CBWG 5IVUA 1T2LA 2FH2A 3EH1A 1SVQA 4CBUG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M2V A;  1YAG G;  1NMD G;  1DEJ S;  1D0N A;  2NUT B;  2VIL A;  1F7S A;  3CJB G;  1VFQ A;  1COF A;  5KYW A;  4S10 C;  3EGX B;  2VAC A;  4PKI G;  1P8Z G;  1Q8G A;  3CJC G;  1KCQ A;  1V6F A;  1P8X A;  2QTV A;  1Q8X A;  3FG6 A;  5KYY A;  5KYU B;  4LIZ A;  3EG9 B;  3FFK A;  2HD7 A;  5HVK D;  3Q2B A;  2FF6 G;  1T3Y A;  1AK7 A;  2FH3 A;  2D8B A;  1EQY S;  2LXX A;  5KYU A;  3EGD A;  1AHQ A;  2MOT A;  3EG9 A;  1C0F S;  5HVK B;  1H1V G;  1M2V B;  1PD1 A;  3A5O S;  2LJ8 A;  1WNJ A;  5A1M A;  3L50 A;  1MDU A;  1J72 A;  1RGI G;  1SVY A;  3A5N S;  3DAW B;  4BEX 1;  2KVK A;  2FGH A;  2I2Q A;  3EGD B;  1NPH A;  1VKK A;  2XF1 A;  5KYN A;  1SVR A;  4KED A;  1AK6 A;  1X67 A;  3FG7 A;  1TMW A;  1WFS A;  5DD2 A;  5FAF A;  1PCX A;  2LLF A;  5KYY B;  2FH4 A;  1CFY A;  1NM1 G;  3EFO A;  3A5L S;  3FFN A;  2VIK A;  1T3X A;  2XFA A;  2W0I A;  2FH1 A;  1CNU A;  1YVN G;  2FF3 A;  5KYX A;  4CBX G;  3EFO B;  1M2O A;  4Z94 G;  4KEE A;  2NUT A;  4JD2 H;  1JHW A;  1C0G S;  5FAE A;  3CI5 G;  5KYW B;  2L72 A;  1D4X G;  1T44 G;  3EGX A;  2NUP B;  5KYX B;  1HQZ 1;  1TVJ A;  1PD0 A;  1WM4 A;  3TU5 B;  3EH2 A;  1QPV A;  4PKG G;  1ESV S;  1NLV G;  2NUP A;  2MV2 A;  3CIP G;  5L6W C;  4KEF A;  4PKH B;  1UDM A;  3A5M S;  1M4J A;  2MP4 A;  4CBW G;  5IVU A;  1T2L A;  2FH2 A;  3EH1 A;  1SVQ A;  4CBU G; 
#chains in the Genus database with same CATH topology
 1M2V A;  1YAG G;  1NMD G;  1DEJ S;  1D0N A;  2NUT B;  2VIL A;  1F7S A;  3CJB G;  1VFQ A;  1COF A;  5KYW A;  4S10 C;  3EGX B;  2VAC A;  4PKI G;  1P8Z G;  1Q8G A;  3CJC G;  1KCQ A;  1V6F A;  1P8X A;  2QTV A;  1Q8X A;  3FG6 A;  5KYY A;  5KYU B;  4LIZ A;  3EG9 B;  3FFK A;  2HD7 A;  5HVK D;  3Q2B A;  2FF6 G;  1T3Y A;  1AK7 A;  2FH3 A;  2D8B A;  1EQY S;  2LXX A;  5KYU A;  3EGD A;  1AHQ A;  2MOT A;  3EG9 A;  1C0F S;  5HVK B;  1H1V G;  1M2V B;  1PD1 A;  3A5O S;  2LJ8 A;  1WNJ A;  5A1M A;  3L50 A;  1MDU A;  1J72 A;  1RGI G;  1SVY A;  3A5N S;  3DAW B;  4BEX 1;  2KVK A;  2FGH A;  2I2Q A;  3EGD B;  1NPH A;  1VKK A;  2XF1 A;  5KYN A;  1SVR A;  4KED A;  1AK6 A;  1X67 A;  3FG7 A;  1TMW A;  1WFS A;  5DD2 A;  5FAF A;  1PCX A;  2LLF A;  5KYY B;  2FH4 A;  1CFY A;  1NM1 G;  3EFO A;  3A5L S;  3FFN A;  2VIK A;  1T3X A;  2XFA A;  2W0I A;  2FH1 A;  1CNU A;  1YVN G;  2FF3 A;  5KYX A;  4CBX G;  3DA7 A;  3EFO B;  1M2O A;  4Z94 G;  4KEE A;  2NUT A;  4JD2 H;  1JHW A;  1C0G S;  5FAE A;  3CI5 G;  5KYW B;  2L72 A;  1D4X G;  1T44 G;  3EGX A;  2NUP B;  5KYX B;  1HQZ 1;  1TVJ A;  1PD0 A;  1WM4 A;  3TU5 B;  3EH2 A;  1QPV A;  4PKG G;  1ESV S;  1NLV G;  2NUP A;  2MV2 A;  3CIP G;  5L6W C;  4KEF A;  4PKH B;  1UDM A;  3A5M S;  1M4J A;  2MP4 A;  4CBW G;  5IVU A;  1T2L A;  2FH2 A;  3EH1 A;  1SVQ A;  4CBU G; 
#chains in the Genus database with same CATH homology
 1M2V A;  1YAG G;  1NMD G;  1DEJ S;  1D0N A;  2NUT B;  2VIL A;  1F7S A;  3CJB G;  1VFQ A;  1COF A;  5KYW A;  4S10 C;  3EGX B;  2VAC A;  4PKI G;  1P8Z G;  1Q8G A;  3CJC G;  1KCQ A;  1V6F A;  1P8X A;  2QTV A;  1Q8X A;  3FG6 A;  5KYY A;  5KYU B;  4LIZ A;  3EG9 B;  3FFK A;  2HD7 A;  5HVK D;  3Q2B A;  2FF6 G;  1T3Y A;  1AK7 A;  2FH3 A;  2D8B A;  1EQY S;  2LXX A;  5KYU A;  3EGD A;  1AHQ A;  2MOT A;  3EG9 A;  1C0F S;  5HVK B;  1H1V G;  1M2V B;  1PD1 A;  3A5O S;  2LJ8 A;  1WNJ A;  5A1M A;  3L50 A;  1MDU A;  1J72 A;  1RGI G;  1SVY A;  3A5N S;  3DAW B;  4BEX 1;  2KVK A;  2FGH A;  2I2Q A;  3EGD B;  1NPH A;  1VKK A;  2XF1 A;  5KYN A;  1SVR A;  4KED A;  1AK6 A;  1X67 A;  3FG7 A;  1TMW A;  1WFS A;  5DD2 A;  5FAF A;  1PCX A;  2LLF A;  5KYY B;  2FH4 A;  1CFY A;  1NM1 G;  3EFO A;  3A5L S;  3FFN A;  2VIK A;  1T3X A;  2XFA A;  2W0I A;  2FH1 A;  1CNU A;  1YVN G;  2FF3 A;  5KYX A;  4CBX G;  3DA7 A;  3EFO B;  1M2O A;  4Z94 G;  4KEE A;  2NUT A;  4JD2 H;  1JHW A;  1C0G S;  5FAE A;  3CI5 G;  5KYW B;  2L72 A;  1D4X G;  1T44 G;  3EGX A;  2NUP B;  5KYX B;  1HQZ 1;  1TVJ A;  1PD0 A;  1WM4 A;  3TU5 B;  3EH2 A;  1QPV A;  4PKG G;  1ESV S;  1NLV G;  2NUP A;  2MV2 A;  3CIP G;  5L6W C;  4KEF A;  4PKH B;  1UDM A;  3A5M S;  1M4J A;  2MP4 A;  4CBW G;  5IVU A;  1T2L A;  2FH2 A;  3EH1 A;  1SVQ A;  4CBU G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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