3FVHA

Polo-like kinase 1 polo box domain in complex with ac-lhspta-nh2 peptide
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
233
structure length
233
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle, peptide binding protein
molecule keywords Serine/threonine-protein kinase PLK1
total genus 79
structure length 233
sequence length 233
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2009-01-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3fvhA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3fvhA01
5LHZA 4YYPA 5DNJA 4DFWA 3C5LA 4X9WA 4WHLA 3HIKA 5DMSA 4HABA 4XB0A 4E67A 3RQ7A 3Q1IA 4HCOA 4X9RA 3HIHA 4O6WA 5DMVC 5J19A 4LKMA 3FVHA 3P35A 4E9DA 3BZIA 1Q4OA 4WHHA 4O56A 4HY2A 2N19A 4RCPA 3P2WA 1Q4KA 1UMWA 4X9VA 4H71A 3P34A 4E9CA 3P37A 4J7BB 4LKLA 3P36A 4H5XA 4O9WA 2OGQA 4RS6A 4WHKA 2OJXA 3P2ZA
chains in the Genus database with same CATH superfamily
4YYPA 4N7ZA 4DFWA 4WHLA 4E67A 4HCOA 4X9RA 3FS3A 4E9DA 4WHHA 4CXUA 3HMJG 2E50A 3ED4A 1P49A 4H71A 1E2TA 3P37A 4RS6A 4H5XA 4O9WA 4X9VA 2VKZG 3P2ZA 5LHZA 4X9WA 4O6WA 3BZIA 1Q4OA 3LM3A 1AUKA 3LXQA 1E2SP 4HY2A 4RCPA 3P2WA 1UMWA 4CXKA 3P34A 4E9CA 1E33P 4CYRA 3GYWA 1A87A 4J7BB 4N7VA 4G7NA 4WHKA 1HDHA 1N2KA 3P36A 1F34B 4FDJA 4XB0A 4LKMA 5DMVC 1N2LA 3KDRA 4O56A 4NK7A 3GYVA 1E3CP 4NKBA 2I9ZA 2UV8G 4CXSA 2I9XA 1FSUA 2OJXA 5DNJA 3C5LA 4CYSA 2IA9A 3HIKA 5DMSA 4HABA 3RQ7A 3Q1IA 5J19A 3HIHA 3FVHA 4N9JA 3P35A 3HFDA 5DAYA 1F32A 4FDIA 2N19A 1E1ZP 1Q4KA 2QZUA 4LKLA 5AJ9A 2OGQA
chains in the Genus database with same CATH topology
5LHZA 4YYPA 5DNJA 4DFWA 3C5LA 4X9WA 4WHLA 3HIKA 5DMSA 4HABA 4XB0A 4E67A 3RQ7A 3Q1IA 4HCOA 4X9RA 3HIHA 4O6WA 5DMVC 5J19A 4LKMA 3FVHA 3P35A 4E9DA 3BZIA 1Q4OA 4WHHA 4O56A 4HY2A 2N19A 4RCPA 3P2WA 1Q4KA 1UMWA 4X9VA 4H71A 3P34A 4E9CA 3P37A 4J7BB 4LKLA 3P36A 4H5XA 4O9WA 2OGQA 4RS6A 4WHKA 2OJXA 3P2ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LHZ A;  4YYP A;  5DNJ A;  4DFW A;  3C5L A;  4X9W A;  4WHL A;  3HIK A;  5DMS A;  4HAB A;  4XB0 A;  4E67 A;  3RQ7 A;  3Q1I A;  4HCO A;  4X9R A;  3HIH A;  4O6W A;  5DMV C;  5J19 A;  4LKM A;  3FVH A;  3P35 A;  4E9D A;  3BZI A;  1Q4O A;  4WHH A;  4O56 A;  4HY2 A;  2N19 A;  4RCP A;  3P2W A;  1Q4K A;  1UMW A;  4X9V A;  4H71 A;  3P34 A;  4E9C A;  3P37 A;  4J7B B;  4LKL A;  3P36 A;  4H5X A;  4O9W A;  2OGQ A;  4RS6 A;  4WHK A;  2OJX A;  3P2Z A; 
#chains in the Genus database with same CATH topology
 4YYP A;  4N7Z A;  4DFW A;  4WHL A;  4E67 A;  4HCO A;  4X9R A;  3FS3 A;  4E9D A;  4WHH A;  4CXU A;  3HMJ G;  2E50 A;  3ED4 A;  1P49 A;  4H71 A;  1E2T A;  3P37 A;  4RS6 A;  4H5X A;  4O9W A;  4X9V A;  2VKZ G;  3P2Z A;  5LHZ A;  4X9W A;  4O6W A;  3BZI A;  1Q4O A;  3LM3 A;  1AUK A;  3LXQ A;  1E2S P;  4HY2 A;  4RCP A;  3P2W A;  1UMW A;  4CXK A;  3P34 A;  4E9C A;  1E33 P;  4CYR A;  3GYW A;  1A87 A;  4J7B B;  4N7V A;  4G7N A;  4WHK A;  1HDH A;  1N2K A;  3P36 A;  1F34 B;  4FDJ A;  4XB0 A;  4LKM A;  5DMV C;  1N2L A;  3KDR A;  4O56 A;  4NK7 A;  3GYV A;  1E3C P;  4NKB A;  2I9Z A;  2UV8 G;  4CXS A;  2I9X A;  1FSU A;  2OJX A;  5DNJ A;  3C5L A;  4CYS A;  2IA9 A;  3HIK A;  5DMS A;  4HAB A;  3RQ7 A;  3Q1I A;  5J19 A;  3HIH A;  3FVH A;  4N9J A;  3P35 A;  3HFD A;  5DAY A;  1F32 A;  4FDI A;  2N19 A;  1E1Z P;  1Q4K A;  2QZU A;  4LKL A;  5AJ9 A;  2OGQ A; 
#chains in the Genus database with same CATH homology
 5LHZ A;  4YYP A;  5DNJ A;  4DFW A;  3C5L A;  4X9W A;  4WHL A;  3HIK A;  5DMS A;  4HAB A;  4XB0 A;  4E67 A;  3RQ7 A;  3Q1I A;  4HCO A;  4X9R A;  3HIH A;  4O6W A;  5DMV C;  5J19 A;  4LKM A;  3FVH A;  3P35 A;  4E9D A;  3BZI A;  1Q4O A;  4WHH A;  4O56 A;  4HY2 A;  2N19 A;  4RCP A;  3P2W A;  1Q4K A;  1UMW A;  4X9V A;  4H71 A;  3P34 A;  4E9C A;  3P37 A;  4J7B B;  4LKL A;  3P36 A;  4H5X A;  4O9W A;  2OGQ A;  4RS6 A;  4WHK A;  2OJX A;  3P2Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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