3FVHA

Polo-like kinase 1 polo box domain in complex with ac-lhspta-nh2 peptide
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
233
structure length
233
Chain Sequence
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Serine/threonine-protein kinase PLK1
publication title Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
pubmed doi rcsb
source organism Homo sapiens
molecule tags Cell cycle, peptide binding protein
total genus 79
structure length 233
sequence length 233
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2009-01-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3fvhA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3fvhA01
3HIKA 4O56A 4E67A 1UMWA 3Q1IA 4WHHA 4DFWA 4H71A 4LKMA 4RS6A 4H5XA 4O6WA 4O9WA 4RCPA 5DNJA 2N19A 4LKLA 4J7BB 4X9VA 4X9RA 5DMSA 3P35A 2OJXA 3C5LA 3P34A 3P37A 4YYPA 1Q4KA 4HABA 3BZIA 4X9WA 4E9DA 4WHKA 1Q4OA 3P2WA 3P2ZA 5DMVC 5LHZA 2OGQA 3P36A 4E9CA 5J19A 3FVHA 3HIHA 4WHLA 4HY2A 4HCOA 4XB0A 3RQ7A
chains in the Genus database with same CATH superfamily
4N9JA 1UMWA 3HMJG 4CXSA 4H71A 4O6WA 5DNJA 4NKBA 5DMSA 4FDJA 4YYPA 2I9XA 3BZIA 4X9WA 2IA9A 3P2WA 3P2ZA 3HIHA 1N2LA 4E67A 4WHHA 4DFWA 3KDRA 4RS6A 4H5XA 3GYWA 4RCPA 4LKLA 4CXUA 4CXKA 1A87A 2VKZG 4N7ZA 1E2SP 1HDHA 1E33P 1Q4KA 4CYRA 3LXQA 1F32A 1N2KA 4E9CA 3FVHA 3RQ7A 3HIKA 4O56A 3FS3A 2E50A 4O9WA 2UV8G 4X9VA 5DAYA 4X9RA 4G7NA 1E2TA 3P35A 3C5LA 3P37A 4CYSA 4E9DA 1E3CP 2I9ZA 4WHKA 5DMVC 1FSUA 1F34B 3P36A 4NK7A 4WHLA 4HCOA 4XB0A 3GYVA 4N7VA 5AJ9A 3Q1IA 3HFDA 2QZUA 4LKMA 2N19A 4J7BB 2OJXA 3P34A 1AUKA 4HABA 3ED4A 1P49A 1Q4OA 5LHZA 2OGQA 1E1ZP 4FDIA 5J19A 4HY2A 3LM3A
chains in the Genus database with same CATH topology
3HIKA 4O56A 4E67A 1UMWA 3Q1IA 4WHHA 4DFWA 4H71A 4LKMA 4RS6A 4H5XA 4O6WA 4O9WA 4RCPA 5DNJA 2N19A 4LKLA 4J7BB 4X9VA 4X9RA 5DMSA 3P35A 2OJXA 3C5LA 3P34A 3P37A 4YYPA 1Q4KA 4HABA 3BZIA 4X9WA 4E9DA 4WHKA 1Q4OA 3P2WA 3P2ZA 5DMVC 5LHZA 2OGQA 3P36A 4E9CA 5J19A 3FVHA 3HIHA 4WHLA 4HY2A 4HCOA 4XB0A 3RQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HIK A;  4O56 A;  4E67 A;  1UMW A;  3Q1I A;  4WHH A;  4DFW A;  4H71 A;  4LKM A;  4RS6 A;  4H5X A;  4O6W A;  4O9W A;  4RCP A;  5DNJ A;  2N19 A;  4LKL A;  4J7B B;  4X9V A;  4X9R A;  5DMS A;  3P35 A;  2OJX A;  3C5L A;  3P34 A;  3P37 A;  4YYP A;  1Q4K A;  4HAB A;  3BZI A;  4X9W A;  4E9D A;  4WHK A;  1Q4O A;  3P2W A;  3P2Z A;  5DMV C;  5LHZ A;  2OGQ A;  3P36 A;  4E9C A;  5J19 A;  3FVH A;  3HIH A;  4WHL A;  4HY2 A;  4HCO A;  4XB0 A;  3RQ7 A; 
#chains in the Genus database with same CATH topology
 4N9J A;  1UMW A;  3HMJ G;  4CXS A;  4H71 A;  4O6W A;  5DNJ A;  4NKB A;  5DMS A;  4FDJ A;  4YYP A;  2I9X A;  3BZI A;  4X9W A;  2IA9 A;  3P2W A;  3P2Z A;  3HIH A;  1N2L A;  4E67 A;  4WHH A;  4DFW A;  3KDR A;  4RS6 A;  4H5X A;  3GYW A;  4RCP A;  4LKL A;  4CXU A;  4CXK A;  1A87 A;  2VKZ G;  4N7Z A;  1E2S P;  1HDH A;  1E33 P;  1Q4K A;  4CYR A;  3LXQ A;  1F32 A;  1N2K A;  4E9C A;  3FVH A;  3RQ7 A;  3HIK A;  4O56 A;  3FS3 A;  2E50 A;  4O9W A;  2UV8 G;  4X9V A;  5DAY A;  4X9R A;  4G7N A;  1E2T A;  3P35 A;  3C5L A;  3P37 A;  4CYS A;  4E9D A;  1E3C P;  2I9Z A;  4WHK A;  5DMV C;  1FSU A;  1F34 B;  3P36 A;  4NK7 A;  4WHL A;  4HCO A;  4XB0 A;  3GYV A;  4N7V A;  5AJ9 A;  3Q1I A;  3HFD A;  2QZU A;  4LKM A;  2N19 A;  4J7B B;  2OJX A;  3P34 A;  1AUK A;  4HAB A;  3ED4 A;  1P49 A;  1Q4O A;  5LHZ A;  2OGQ A;  1E1Z P;  4FDI A;  5J19 A;  4HY2 A;  3LM3 A; 
#chains in the Genus database with same CATH homology
 3HIK A;  4O56 A;  4E67 A;  1UMW A;  3Q1I A;  4WHH A;  4DFW A;  4H71 A;  4LKM A;  4RS6 A;  4H5X A;  4O6W A;  4O9W A;  4RCP A;  5DNJ A;  2N19 A;  4LKL A;  4J7B B;  4X9V A;  4X9R A;  5DMS A;  3P35 A;  2OJX A;  3C5L A;  3P34 A;  3P37 A;  4YYP A;  1Q4K A;  4HAB A;  3BZI A;  4X9W A;  4E9D A;  4WHK A;  1Q4O A;  3P2W A;  3P2Z A;  5DMV C;  5LHZ A;  2OGQ A;  3P36 A;  4E9C A;  5J19 A;  3FVH A;  3HIH A;  4WHL A;  4HY2 A;  4HCO A;  4XB0 A;  3RQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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