3FWAA

Structure of berberine bridge enzyme, c166a variant in complex with (s)-reticuline
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
sequence length
497
structure length
497
Chain Sequence
b'DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAGWAPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANF'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Reticuline oxidase
publication title Structural roles of biocovalent flaninylation in berberine bridge enzyme
rcsb
source organism Eschscholzia californica
molecule tags Flavoprotein
total genus 169
structure length 497
sequence length 497
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2009-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3fwaA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3fwaA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3fwaA03
3SR6B 5L6FA 4ZOHB 1WYGA 1W1JA 4UD8A 3AN1A 5ADZA 1W1LA 1ZXIC 2GQUA 2AXRA 5AWVA 1N63C 2Q4WA 5K8EA 2W3SA 4PVJA 3D2JA 3PM9A 4OALA 3POPA 2BVFA 4JAYA 1N5WC 2BVHA 1ZR6A 3TX1A 1F0XA 3TSJA 3GSYA 5AE1A 4JB1A 5HHZA 4XLOA 3B9JB 1W1OA 2Y4GA 4PWBA 5FXFA 1VDVA 3VTEA 2VFVA 3S1FA 2MBRA 4PZFA 3W8WA 3S1CA 4MLAA 1DZNA 2W55A 5L6GA 4BC7A 3S1EA 1T3QC 2BVGA 1FO4A 2EXRA 1WVEA 1N61C 1V97A 3AMZA 1VAOA 5I1VA 2GQTA 3FW7A 4PVEA 1WVFA 1W1SA 3D2DA 4EC3A 2IPIA 1E8FA 2Y08A 1MBBA 1FFVC 5FXDA 4BCAA 1N60C 3RJAA 1HSKA 4PVHA 4PWCA 5D79A 2Y3RA 1W1KA 5AE3A 3PQBA 3EUB3 3AM9A 1W1QA 1JROA 1FFUC 3HSUA 3RJ8A 1W1MA 1QLTA 5FXPA 2QPMA 3NRZB 3W8ZA 2Y3SA 2I0KA 3NVZB 1I19A 5FXEA 3FW9A 1DIIA 4DNSA 1N5XA 3FWAA 2QKNA 1AHUA 3BW7A 1E8HA 1QLUA 2VAOA 3ETRB 3FW8A 2Q85A 3S1DA 2E3TA 2VFSA 1E8GA 2W54A 2VFTA 3C0PA 1AHZA 3DQ0A 4PYTA 1UXYA 1E0YA 3JS8A 3TSHA 4PVKA 3I99A 1FIQB 3KJMA 4BBYA 4ML8A 5AE2A 5HMRA 3W8XA 1AHVA 5HQXA 3D2HA 4O95A 2VFUA 1W1RA 4BC9A 1N62C 1MBTA 2VFRA 3NS1B 5I1WA 1DIQA 2WDWA 2W3RA
chains in the Genus database with same CATH superfamily
3SR6B 5L6FA 4ZOHB 1WYGA 1W1JA 4UD8A 3AN1A 5ADZA 3EJDB 1W1LA 1ZXIC 2GQUA 2AXRA 5AWVA 1N63C 2Q4WA 2RK5A 3LAEA 5K8EA 2W3SA 4PVJA 3D2JA 3PM9A 1RM6B 4OALA 3POPA 2BVFA 4JAYA 1N5WC 2BVHA 1ZR6A 3TX1A 1F0XA 3TSJA 3GSYA 5AE1A 4JB1A 5HHZA 4XLOA 3B9JB 1W1OA 2Y4GA 4PWBA 5FXFA 3EJBB 1VDVA 3NVVB 3VTEA 2VFVA 2O3GA 3S1FA 2MBRA 2NQWA 4PZFA 3W8WA 3S1CA 4MLAA 2P3HA 1DZNA 2W55A 5L6GA 4BC7A 3S1EA 1T3QC 2BVGA 1FO4A 2EXRA 1WVEA 1N61C 1V97A 3AMZA 1VAOA 5I1VA 2GQTA 3FW7A 4PVEA 1WVFA 2PLIA 1W1SA 4HG0A 3D2DA 4EC3A 2IPIA 1E8FA 2Y08A 1MBBA 2P13A 1FFVC 5FXDA 5G5GB 4BCAA 1N60C 3RJAA 1HSKA 4PVHA 4PWCA 5D79A 2Y3RA 1W1KA 5AE3A 3PQBA 3EUB3 3AM9A 1W1QA 3NVYB 1JROA 1FFUC 2OAIA 2P4PA 3HSUA 3RJ8A 1W1MA 2PLSA 1QLTA 5FXPA 2QPMA 3NRZB 3W8ZA 2R8DA 2YVSA 3HRDC 1JRPA 2Y3SA 2I0KA 3NVZB 1I19A 5FXEA 3FW9A 1DIIA 4DNSA 1N5XA 3FWAA 2QKNA 1AHUA 3BW7A 1E8HA 1QLUA 2VAOA 3ETRB 3FW8A 3NVWB 2R2ZA 2UUVA 2Q85A 3S1DA 2E3TA 2VFSA 1E8GA 2W54A 2VFTA 3C0PA 1AHZA 3DQ0A 4PYTA 2UUUA 1UXYA 1E0YA 3JS8A 3TSHA 4PVKA 3I99A 1FIQB 3KJMA 4BBYA 4ML8A 5AE2A 5HMRA 3W8XA 1AHVA 5HQXA 3D2HA 4O95A 5G5HB 2VFUA 3EJEB 1W1RA 3DEDA 3LLBA 4BC9A 1N62C 1MBTA 2VFRA 3NS1B 1SB3B 5I1WA 1DIQA 2WDWA 2W3RA
chains in the Genus database with same CATH topology
3SR6B 5L6FA 4ZOHB 1WYGA 1W1JA 4UD8A 3AN1A 5ADZA 1W1LA 1ZXIC 2GQUA 2AXRA 5AWVA 1N63C 2Q4WA 2RK5A 3LAEA 5K8EA 2W3SA 4PVJA 3D2JA 3PM9A 1RM6B 4OALA 3POPA 2BVFA 4JAYA 1N5WC 2BVHA 1ZR6A 3TX1A 1F0XA 3TSJA 3GSYA 5AE1A 4JB1A 5HHZA 4XLOA 3B9JB 1W1OA 2Y4GA 4PWBA 5FXFA 1VDVA 3NVVB 3VTEA 2VFVA 2O3GA 3S1FA 2MBRA 2NQWA 4PZFA 3W8WA 3S1CA 4MLAA 2P3HA 1DZNA 2W55A 5L6GA 4BC7A 3S1EA 1T3QC 2BVGA 1FO4A 2EXRA 1WVEA 1N61C 1V97A 3AMZA 1VAOA 5I1VA 2GQTA 3FW7A 4PVEA 1WVFA 2PLIA 1W1SA 4HG0A 3D2DA 4EC3A 2IPIA 1E8FA 2Y08A 1MBBA 2P13A 1FFVC 5FXDA 5G5GB 4BCAA 1N60C 3RJAA 1HSKA 4PVHA 4PWCA 5D79A 2Y3RA 1W1KA 5AE3A 3PQBA 3EUB3 3AM9A 1W1QA 3NVYB 1JROA 1FFUC 2OAIA 2P4PA 3HSUA 3RJ8A 1W1MA 2PLSA 1QLTA 5FXPA 2QPMA 3NRZB 3W8ZA 2R8DA 2YVSA 3HRDC 1JRPA 2Y3SA 2I0KA 3NVZB 1I19A 5FXEA 3FW9A 1DIIA 4DNSA 1N5XA 3FWAA 2QKNA 1AHUA 3BW7A 1E8HA 1QLUA 2VAOA 3ETRB 3FW8A 2R2ZA 3NVWB 2UUVA 2Q85A 3S1DA 2E3TA 2VFSA 1E8GA 2W54A 2VFTA 3C0PA 1AHZA 3DQ0A 4PYTA 2UUUA 1UXYA 1E0YA 3JS8A 3TSHA 4PVKA 3I99A 1FIQB 3KJMA 4BBYA 4ML8A 5AE2A 5HMRA 3W8XA 1AHVA 5HQXA 3D2HA 4O95A 5G5HB 2VFUA 1W1RA 3DEDA 3LLBA 4BC9A 1N62C 1MBTA 2VFRA 3NS1B 1SB3B 5I1WA 1DIQA 2WDWA 2W3RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SR6 B;  5L6F A;  4ZOH B;  1WYG A;  1W1J A;  4UD8 A;  3AN1 A;  5ADZ A;  1W1L A;  1ZXI C;  2GQU A;  2AXR A;  5AWV A;  1N63 C;  2Q4W A;  5K8E A;  2W3S A;  4PVJ A;  3D2J A;  3PM9 A;  4OAL A;  3POP A;  2BVF A;  4JAY A;  1N5W C;  2BVH A;  1ZR6 A;  3TX1 A;  1F0X A;  3TSJ A;  3GSY A;  5AE1 A;  4JB1 A;  5HHZ A;  4XLO A;  3B9J B;  1W1O A;  2Y4G A;  4PWB A;  5FXF A;  1VDV A;  3VTE A;  2VFV A;  3S1F A;  2MBR A;  4PZF A;  3W8W A;  3S1C A;  4MLA A;  1DZN A;  2W55 A;  5L6G A;  4BC7 A;  3S1E A;  1T3Q C;  2BVG A;  1FO4 A;  2EXR A;  1WVE A;  1N61 C;  1V97 A;  3AMZ A;  1VAO A;  5I1V A;  2GQT A;  3FW7 A;  4PVE A;  1WVF A;  1W1S A;  3D2D A;  4EC3 A;  2IPI A;  1E8F A;  2Y08 A;  1MBB A;  1FFV C;  5FXD A;  4BCA A;  1N60 C;  3RJA A;  1HSK A;  4PVH A;  4PWC A;  5D79 A;  2Y3R A;  1W1K A;  5AE3 A;  3PQB A;  3EUB 3;  3AM9 A;  1W1Q A;  1JRO A;  1FFU C;  3HSU A;  3RJ8 A;  1W1M A;  1QLT A;  5FXP A;  2QPM A;  3NRZ B;  3W8Z A;  2Y3S A;  2I0K A;  3NVZ B;  1I19 A;  5FXE A;  3FW9 A;  1DII A;  4DNS A;  1N5X A;  3FWA A;  2QKN A;  1AHU A;  3BW7 A;  1E8H A;  1QLU A;  2VAO A;  3ETR B;  3FW8 A;  2Q85 A;  3S1D A;  2E3T A;  2VFS A;  1E8G A;  2W54 A;  2VFT A;  3C0P A;  1AHZ A;  3DQ0 A;  4PYT A;  1UXY A;  1E0Y A;  3JS8 A;  3TSH A;  4PVK A;  3I99 A;  1FIQ B;  3KJM A;  4BBY A;  4ML8 A;  5AE2 A;  5HMR A;  3W8X A;  1AHV A;  5HQX A;  3D2H A;  4O95 A;  2VFU A;  1W1R A;  4BC9 A;  1N62 C;  1MBT A;  2VFR A;  3NS1 B;  5I1W A;  1DIQ A;  2WDW A;  2W3R A; 
#chains in the Genus database with same CATH topology
 3SR6 B;  5L6F A;  4ZOH B;  1WYG A;  1W1J A;  4UD8 A;  3AN1 A;  5ADZ A;  3EJD B;  1W1L A;  1ZXI C;  2GQU A;  2AXR A;  5AWV A;  1N63 C;  2Q4W A;  2RK5 A;  3LAE A;  5K8E A;  2W3S A;  4PVJ A;  3D2J A;  3PM9 A;  1RM6 B;  4OAL A;  3POP A;  2BVF A;  4JAY A;  1N5W C;  2BVH A;  1ZR6 A;  3TX1 A;  1F0X A;  3TSJ A;  3GSY A;  5AE1 A;  4JB1 A;  5HHZ A;  4XLO A;  3B9J B;  1W1O A;  2Y4G A;  4PWB A;  5FXF A;  3EJB B;  1VDV A;  3NVV B;  3VTE A;  2VFV A;  2O3G A;  3S1F A;  2MBR A;  2NQW A;  4PZF A;  3W8W A;  3S1C A;  4MLA A;  2P3H A;  1DZN A;  2W55 A;  5L6G A;  4BC7 A;  3S1E A;  1T3Q C;  2BVG A;  1FO4 A;  2EXR A;  1WVE A;  1N61 C;  1V97 A;  3AMZ A;  1VAO A;  5I1V A;  2GQT A;  3FW7 A;  4PVE A;  1WVF A;  2PLI A;  1W1S A;  4HG0 A;  3D2D A;  4EC3 A;  2IPI A;  1E8F A;  2Y08 A;  1MBB A;  2P13 A;  1FFV C;  5FXD A;  5G5G B;  4BCA A;  1N60 C;  3RJA A;  1HSK A;  4PVH A;  4PWC A;  5D79 A;  2Y3R A;  1W1K A;  5AE3 A;  3PQB A;  3EUB 3;  3AM9 A;  1W1Q A;  3NVY B;  1JRO A;  1FFU C;  2OAI A;  2P4P A;  3HSU A;  3RJ8 A;  1W1M A;  2PLS A;  1QLT A;  5FXP A;  2QPM A;  3NRZ B;  3W8Z A;  2R8D A;  2YVS A;  3HRD C;  1JRP A;  2Y3S A;  2I0K A;  3NVZ B;  1I19 A;  5FXE A;  3FW9 A;  1DII A;  4DNS A;  1N5X A;  3FWA A;  2QKN A;  1AHU A;  3BW7 A;  1E8H A;  1QLU A;  2VAO A;  3ETR B;  3FW8 A;  3NVW B;  2R2Z A;  2UUV A;  2Q85 A;  3S1D A;  2E3T A;  2VFS A;  1E8G A;  2W54 A;  2VFT A;  3C0P A;  1AHZ A;  3DQ0 A;  4PYT A;  2UUU A;  1UXY A;  1E0Y A;  3JS8 A;  3TSH A;  4PVK A;  3I99 A;  1FIQ B;  3KJM A;  4BBY A;  4ML8 A;  5AE2 A;  5HMR A;  3W8X A;  1AHV A;  5HQX A;  3D2H A;  4O95 A;  5G5H B;  2VFU A;  3EJE B;  1W1R A;  3DED A;  3LLB A;  4BC9 A;  1N62 C;  1MBT A;  2VFR A;  3NS1 B;  1SB3 B;  5I1W A;  1DIQ A;  2WDW A;  2W3R A; 
#chains in the Genus database with same CATH homology
 3SR6 B;  5L6F A;  4ZOH B;  1WYG A;  1W1J A;  4UD8 A;  3AN1 A;  5ADZ A;  1W1L A;  1ZXI C;  2GQU A;  2AXR A;  5AWV A;  1N63 C;  2Q4W A;  2RK5 A;  3LAE A;  5K8E A;  2W3S A;  4PVJ A;  3D2J A;  3PM9 A;  1RM6 B;  4OAL A;  3POP A;  2BVF A;  4JAY A;  1N5W C;  2BVH A;  1ZR6 A;  3TX1 A;  1F0X A;  3TSJ A;  3GSY A;  5AE1 A;  4JB1 A;  5HHZ A;  4XLO A;  3B9J B;  1W1O A;  2Y4G A;  4PWB A;  5FXF A;  1VDV A;  3NVV B;  3VTE A;  2VFV A;  2O3G A;  3S1F A;  2MBR A;  2NQW A;  4PZF A;  3W8W A;  3S1C A;  4MLA A;  2P3H A;  1DZN A;  2W55 A;  5L6G A;  4BC7 A;  3S1E A;  1T3Q C;  2BVG A;  1FO4 A;  2EXR A;  1WVE A;  1N61 C;  1V97 A;  3AMZ A;  1VAO A;  5I1V A;  2GQT A;  3FW7 A;  4PVE A;  1WVF A;  2PLI A;  1W1S A;  4HG0 A;  3D2D A;  4EC3 A;  2IPI A;  1E8F A;  2Y08 A;  1MBB A;  2P13 A;  1FFV C;  5FXD A;  5G5G B;  4BCA A;  1N60 C;  3RJA A;  1HSK A;  4PVH A;  4PWC A;  5D79 A;  2Y3R A;  1W1K A;  5AE3 A;  3PQB A;  3EUB 3;  3AM9 A;  1W1Q A;  3NVY B;  1JRO A;  1FFU C;  2OAI A;  2P4P A;  3HSU A;  3RJ8 A;  1W1M A;  2PLS A;  1QLT A;  5FXP A;  2QPM A;  3NRZ B;  3W8Z A;  2R8D A;  2YVS A;  3HRD C;  1JRP A;  2Y3S A;  2I0K A;  3NVZ B;  1I19 A;  5FXE A;  3FW9 A;  1DII A;  4DNS A;  1N5X A;  3FWA A;  2QKN A;  1AHU A;  3BW7 A;  1E8H A;  1QLU A;  2VAO A;  3ETR B;  3FW8 A;  2R2Z A;  3NVW B;  2UUV A;  2Q85 A;  3S1D A;  2E3T A;  2VFS A;  1E8G A;  2W54 A;  2VFT A;  3C0P A;  1AHZ A;  3DQ0 A;  4PYT A;  2UUU A;  1UXY A;  1E0Y A;  3JS8 A;  3TSH A;  4PVK A;  3I99 A;  1FIQ B;  3KJM A;  4BBY A;  4ML8 A;  5AE2 A;  5HMR A;  3W8X A;  1AHV A;  5HQX A;  3D2H A;  4O95 A;  5G5H B;  2VFU A;  1W1R A;  3DED A;  3LLB A;  4BC9 A;  1N62 C;  1MBT A;  2VFR A;  3NS1 B;  1SB3 B;  5I1W A;  1DIQ A;  2WDW A;  2W3R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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