3FWAA

Structure of berberine bridge enzyme, c166a variant in complex with (s)-reticuline
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
sequence length
497
structure length
497
Chain Sequence
DLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPSAIILPGSKEELSNTIRCIRKGSWTIRLRSGGHSYEGLSYTSDTPFILIDLMNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAGWAPTVGTGGHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRGGGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEELEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAFYGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAWNQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMANF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Reticuline oxidase
publication title Structural roles of biocovalent flaninylation in berberine bridge enzyme
rcsb
source organism Eschscholzia californica
molecule tags Flavoprotein
total genus 169
structure length 497
sequence length 497
ec nomenclature ec 1.21.3.3: Reticuline oxidase.
pdb deposition date 2009-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.43.10 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 3fwaA01
3.30.465.50 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3fwaA02
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3fwaA03
1N5XA 2Q85A 1N61C 4JB1A 5HMRA 3NS1B 1MBTA 2VFTA 4PWCA 3S1EA 3RJ8A 3RJAA 1MBBA 3EUB3 2W3RA 3D2DA 5AE3A 1UXYA 3FW8A 5AE2A 4PZFA 4PVJA 4ML8A 1VAOA 4PWBA 5L6FA 3W8ZA 3S1DA 3FW7A 1DIQA 2Y08A 3POPA 4PVKA 3NVZB 1N60C 3W8XA 2QKNA 2E3TA 1E8HA 1W1MA 2AXRA 2VAOA 1HSKA 3ETRB 3I99A 4ZOHB 1FO4A 3W8WA 4BC9A 2QPMA 1DIIA 1DZNA 1E8FA 5I1WA 1AHVA 3TSHA 4BCAA 2GQUA 4MLAA 2BVGA 2IPIA 1QLUA 2W55A 1WVFA 4BBYA 5HHZA 2Q4WA 1AHZA 2VFUA 4BC7A 1T3QC 3NRZB 3GSYA 3S1CA 1N5WC 3VTEA 3D2JA 5ADZA 3PQBA 3D2HA 5FXDA 2BVHA 4UD8A 1FIQB 1ZXIC 1N63C 2BVFA 1FFUC 4DNSA 4EC3A 2MBRA 3BW7A 3HSUA 3PM9A 5FXFA 3AMZA 2GQTA 2VFVA 2Y4GA 1V97A 1W1RA 3TX1A 3DQ0A 1QLTA 5HQXA 1AHUA 1FFVC 1F0XA 4JAYA 4PVHA 1W1KA 5FXEA 3AN1A 5AE1A 1WVEA 2W54A 3SR6B 1E8GA 3FWAA 1W1QA 1ZR6A 2I0KA 4O95A 2EXRA 3AM9A 4PVEA 1E0YA 2Y3SA 4XLOA 3JS8A 2W3SA 4OALA 3B9JB 4PYTA 5FXPA 2VFSA 1W1LA 3S1FA 1N62C 5K8EA 2WDWA 1WYGA 5L6GA 1I19A 3TSJA 1W1OA 3C0PA 3FW9A 5I1VA 2VFRA 1JROA 2Y3RA 1VDVA 1W1JA 5AWVA 5D79A 1W1SA 3KJMA
chains in the Genus database with same CATH superfamily
1N5XA 2Q85A 1N61C 4JB1A 5HMRA 2UUUA 2UUVA 3NS1B 1MBTA 2VFTA 4PWCA 3S1EA 3HRDC 3RJ8A 1JRPA 2OAIA 3RJAA 1MBBA 3EUB3 2W3RA 3D2DA 5AE3A 1UXYA 3FW8A 5AE2A 4PZFA 4PVJA 4ML8A 1VAOA 4PWBA 5L6FA 3W8ZA 3S1DA 3FW7A 1DIQA 2Y08A 3POPA 4PVKA 3NVZB 1N60C 3W8XA 2QKNA 2E3TA 1E8HA 1W1MA 2PLIA 2AXRA 3NVYB 4HG0A 1SB3B 2VAOA 2O3GA 1HSKA 3ETRB 3I99A 4ZOHB 1FO4A 3W8WA 4BC9A 2QPMA 1DIIA 1DZNA 1E8FA 5I1WA 1AHVA 3TSHA 4BCAA 3LAEA 2GQUA 4MLAA 2BVGA 2IPIA 1QLUA 2W55A 1WVFA 4BBYA 5HHZA 2Q4WA 1AHZA 2VFUA 4BC7A 3LLBA 1T3QC 3NRZB 3GSYA 3S1CA 1N5WC 2NQWA 2R2ZA 3VTEA 3D2JA 5ADZA 3PQBA 3D2HA 5FXDA 2BVHA 4UD8A 1FIQB 1ZXIC 1N63C 2BVFA 2PLSA 1FFUC 4DNSA 4EC3A 2RK5A 2MBRA 2P13A 3BW7A 2R8DA 3HSUA 3PM9A 5FXFA 3AMZA 5G5HB 2GQTA 2VFVA 2Y4GA 1V97A 3EJDB 1W1RA 3TX1A 3EJBB 3DQ0A 1QLTA 5HQXA 1AHUA 3DEDA 1FFVC 1F0XA 4JAYA 4PVHA 1W1KA 5FXEA 3AN1A 3NVWB 5AE1A 1WVEA 2W54A 2P4PA 2P3HA 2YVSA 3SR6B 1E8GA 3FWAA 1RM6B 1W1QA 1ZR6A 2I0KA 4O95A 5G5GB 2EXRA 3AM9A 4PVEA 1E0YA 2Y3SA 4XLOA 3JS8A 2W3SA 4OALA 3B9JB 4PYTA 5FXPA 2VFSA 1W1LA 3S1FA 1N62C 5K8EA 3EJEB 2WDWA 1WYGA 5L6GA 1I19A 3TSJA 1W1OA 3C0PA 3FW9A 5I1VA 3NVVB 2VFRA 1JROA 2Y3RA 1VDVA 1W1JA 5AWVA 5D79A 1W1SA 3KJMA
chains in the Genus database with same CATH topology
1N5XA 2Q85A 1N61C 4JB1A 5HMRA 2UUUA 2UUVA 3NS1B 1MBTA 2VFTA 4PWCA 3S1EA 3HRDC 3RJ8A 1JRPA 2OAIA 3RJAA 1MBBA 3EUB3 2W3RA 3D2DA 5AE3A 1UXYA 3FW8A 5AE2A 4PZFA 4PVJA 4ML8A 1VAOA 4PWBA 5L6FA 3W8ZA 3S1DA 3FW7A 1DIQA 2Y08A 3POPA 4PVKA 3NVZB 1N60C 3W8XA 2QKNA 2E3TA 1E8HA 1W1MA 2PLIA 2AXRA 3NVYB 4HG0A 1SB3B 2VAOA 2O3GA 1HSKA 3ETRB 3I99A 4ZOHB 1FO4A 3W8WA 4BC9A 2QPMA 1DIIA 1DZNA 1E8FA 5I1WA 1AHVA 3TSHA 4BCAA 3LAEA 2GQUA 4MLAA 2BVGA 2IPIA 1QLUA 2W55A 1WVFA 4BBYA 5HHZA 2Q4WA 1AHZA 2VFUA 4BC7A 3LLBA 1T3QC 3NRZB 3GSYA 3S1CA 1N5WC 2NQWA 2R2ZA 3VTEA 3D2JA 5ADZA 3PQBA 3D2HA 5FXDA 2BVHA 4UD8A 1FIQB 1ZXIC 1N63C 2BVFA 2PLSA 1FFUC 4DNSA 4EC3A 2RK5A 2MBRA 2P13A 3BW7A 2R8DA 3HSUA 3PM9A 5FXFA 3AMZA 5G5HB 2GQTA 2VFVA 2Y4GA 1V97A 1W1RA 3TX1A 3DQ0A 1QLTA 5HQXA 1AHUA 3DEDA 1FFVC 1F0XA 4JAYA 4PVHA 1W1KA 5FXEA 3AN1A 3NVWB 5AE1A 1WVEA 2W54A 2P4PA 2P3HA 2YVSA 3SR6B 1E8GA 3FWAA 1RM6B 1W1QA 1ZR6A 2I0KA 4O95A 5G5GB 2EXRA 3AM9A 4PVEA 1E0YA 2Y3SA 4XLOA 3JS8A 2W3SA 4OALA 3B9JB 4PYTA 5FXPA 2VFSA 1W1LA 3S1FA 1N62C 5K8EA 2WDWA 1WYGA 5L6GA 1I19A 3TSJA 1W1OA 3C0PA 3FW9A 5I1VA 3NVVB 2VFRA 1JROA 2Y3RA 1VDVA 1W1JA 5AWVA 5D79A 1W1SA 3KJMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N5X A;  2Q85 A;  1N61 C;  4JB1 A;  5HMR A;  3NS1 B;  1MBT A;  2VFT A;  4PWC A;  3S1E A;  3RJ8 A;  3RJA A;  1MBB A;  3EUB 3;  2W3R A;  3D2D A;  5AE3 A;  1UXY A;  3FW8 A;  5AE2 A;  4PZF A;  4PVJ A;  4ML8 A;  1VAO A;  4PWB A;  5L6F A;  3W8Z A;  3S1D A;  3FW7 A;  1DIQ A;  2Y08 A;  3POP A;  4PVK A;  3NVZ B;  1N60 C;  3W8X A;  2QKN A;  2E3T A;  1E8H A;  1W1M A;  2AXR A;  2VAO A;  1HSK A;  3ETR B;  3I99 A;  4ZOH B;  1FO4 A;  3W8W A;  4BC9 A;  2QPM A;  1DII A;  1DZN A;  1E8F A;  5I1W A;  1AHV A;  3TSH A;  4BCA A;  2GQU A;  4MLA A;  2BVG A;  2IPI A;  1QLU A;  2W55 A;  1WVF A;  4BBY A;  5HHZ A;  2Q4W A;  1AHZ A;  2VFU A;  4BC7 A;  1T3Q C;  3NRZ B;  3GSY A;  3S1C A;  1N5W C;  3VTE A;  3D2J A;  5ADZ A;  3PQB A;  3D2H A;  5FXD A;  2BVH A;  4UD8 A;  1FIQ B;  1ZXI C;  1N63 C;  2BVF A;  1FFU C;  4DNS A;  4EC3 A;  2MBR A;  3BW7 A;  3HSU A;  3PM9 A;  5FXF A;  3AMZ A;  2GQT A;  2VFV A;  2Y4G A;  1V97 A;  1W1R A;  3TX1 A;  3DQ0 A;  1QLT A;  5HQX A;  1AHU A;  1FFV C;  1F0X A;  4JAY A;  4PVH A;  1W1K A;  5FXE A;  3AN1 A;  5AE1 A;  1WVE A;  2W54 A;  3SR6 B;  1E8G A;  3FWA A;  1W1Q A;  1ZR6 A;  2I0K A;  4O95 A;  2EXR A;  3AM9 A;  4PVE A;  1E0Y A;  2Y3S A;  4XLO A;  3JS8 A;  2W3S A;  4OAL A;  3B9J B;  4PYT A;  5FXP A;  2VFS A;  1W1L A;  3S1F A;  1N62 C;  5K8E A;  2WDW A;  1WYG A;  5L6G A;  1I19 A;  3TSJ A;  1W1O A;  3C0P A;  3FW9 A;  5I1V A;  2VFR A;  1JRO A;  2Y3R A;  1VDV A;  1W1J A;  5AWV A;  5D79 A;  1W1S A;  3KJM A; 
#chains in the Genus database with same CATH topology
 1N5X A;  2Q85 A;  1N61 C;  4JB1 A;  5HMR A;  2UUU A;  2UUV A;  3NS1 B;  1MBT A;  2VFT A;  4PWC A;  3S1E A;  3HRD C;  3RJ8 A;  1JRP A;  2OAI A;  3RJA A;  1MBB A;  3EUB 3;  2W3R A;  3D2D A;  5AE3 A;  1UXY A;  3FW8 A;  5AE2 A;  4PZF A;  4PVJ A;  4ML8 A;  1VAO A;  4PWB A;  5L6F A;  3W8Z A;  3S1D A;  3FW7 A;  1DIQ A;  2Y08 A;  3POP A;  4PVK A;  3NVZ B;  1N60 C;  3W8X A;  2QKN A;  2E3T A;  1E8H A;  1W1M A;  2PLI A;  2AXR A;  3NVY B;  4HG0 A;  1SB3 B;  2VAO A;  2O3G A;  1HSK A;  3ETR B;  3I99 A;  4ZOH B;  1FO4 A;  3W8W A;  4BC9 A;  2QPM A;  1DII A;  1DZN A;  1E8F A;  5I1W A;  1AHV A;  3TSH A;  4BCA A;  3LAE A;  2GQU A;  4MLA A;  2BVG A;  2IPI A;  1QLU A;  2W55 A;  1WVF A;  4BBY A;  5HHZ A;  2Q4W A;  1AHZ A;  2VFU A;  4BC7 A;  3LLB A;  1T3Q C;  3NRZ B;  3GSY A;  3S1C A;  1N5W C;  2NQW A;  2R2Z A;  3VTE A;  3D2J A;  5ADZ A;  3PQB A;  3D2H A;  5FXD A;  2BVH A;  4UD8 A;  1FIQ B;  1ZXI C;  1N63 C;  2BVF A;  2PLS A;  1FFU C;  4DNS A;  4EC3 A;  2RK5 A;  2MBR A;  2P13 A;  3BW7 A;  2R8D A;  3HSU A;  3PM9 A;  5FXF A;  3AMZ A;  5G5H B;  2GQT A;  2VFV A;  2Y4G A;  1V97 A;  3EJD B;  1W1R A;  3TX1 A;  3EJB B;  3DQ0 A;  1QLT A;  5HQX A;  1AHU A;  3DED A;  1FFV C;  1F0X A;  4JAY A;  4PVH A;  1W1K A;  5FXE A;  3AN1 A;  3NVW B;  5AE1 A;  1WVE A;  2W54 A;  2P4P A;  2P3H A;  2YVS A;  3SR6 B;  1E8G A;  3FWA A;  1RM6 B;  1W1Q A;  1ZR6 A;  2I0K A;  4O95 A;  5G5G B;  2EXR A;  3AM9 A;  4PVE A;  1E0Y A;  2Y3S A;  4XLO A;  3JS8 A;  2W3S A;  4OAL A;  3B9J B;  4PYT A;  5FXP A;  2VFS A;  1W1L A;  3S1F A;  1N62 C;  5K8E A;  3EJE B;  2WDW A;  1WYG A;  5L6G A;  1I19 A;  3TSJ A;  1W1O A;  3C0P A;  3FW9 A;  5I1V A;  3NVV B;  2VFR A;  1JRO A;  2Y3R A;  1VDV A;  1W1J A;  5AWV A;  5D79 A;  1W1S A;  3KJM A; 
#chains in the Genus database with same CATH homology
 1N5X A;  2Q85 A;  1N61 C;  4JB1 A;  5HMR A;  2UUU A;  2UUV A;  3NS1 B;  1MBT A;  2VFT A;  4PWC A;  3S1E A;  3HRD C;  3RJ8 A;  1JRP A;  2OAI A;  3RJA A;  1MBB A;  3EUB 3;  2W3R A;  3D2D A;  5AE3 A;  1UXY A;  3FW8 A;  5AE2 A;  4PZF A;  4PVJ A;  4ML8 A;  1VAO A;  4PWB A;  5L6F A;  3W8Z A;  3S1D A;  3FW7 A;  1DIQ A;  2Y08 A;  3POP A;  4PVK A;  3NVZ B;  1N60 C;  3W8X A;  2QKN A;  2E3T A;  1E8H A;  1W1M A;  2PLI A;  2AXR A;  3NVY B;  4HG0 A;  1SB3 B;  2VAO A;  2O3G A;  1HSK A;  3ETR B;  3I99 A;  4ZOH B;  1FO4 A;  3W8W A;  4BC9 A;  2QPM A;  1DII A;  1DZN A;  1E8F A;  5I1W A;  1AHV A;  3TSH A;  4BCA A;  3LAE A;  2GQU A;  4MLA A;  2BVG A;  2IPI A;  1QLU A;  2W55 A;  1WVF A;  4BBY A;  5HHZ A;  2Q4W A;  1AHZ A;  2VFU A;  4BC7 A;  3LLB A;  1T3Q C;  3NRZ B;  3GSY A;  3S1C A;  1N5W C;  2NQW A;  2R2Z A;  3VTE A;  3D2J A;  5ADZ A;  3PQB A;  3D2H A;  5FXD A;  2BVH A;  4UD8 A;  1FIQ B;  1ZXI C;  1N63 C;  2BVF A;  2PLS A;  1FFU C;  4DNS A;  4EC3 A;  2RK5 A;  2MBR A;  2P13 A;  3BW7 A;  2R8D A;  3HSU A;  3PM9 A;  5FXF A;  3AMZ A;  5G5H B;  2GQT A;  2VFV A;  2Y4G A;  1V97 A;  1W1R A;  3TX1 A;  3DQ0 A;  1QLT A;  5HQX A;  1AHU A;  3DED A;  1FFV C;  1F0X A;  4JAY A;  4PVH A;  1W1K A;  5FXE A;  3AN1 A;  3NVW B;  5AE1 A;  1WVE A;  2W54 A;  2P4P A;  2P3H A;  2YVS A;  3SR6 B;  1E8G A;  3FWA A;  1RM6 B;  1W1Q A;  1ZR6 A;  2I0K A;  4O95 A;  5G5G B;  2EXR A;  3AM9 A;  4PVE A;  1E0Y A;  2Y3S A;  4XLO A;  3JS8 A;  2W3S A;  4OAL A;  3B9J B;  4PYT A;  5FXP A;  2VFS A;  1W1L A;  3S1F A;  1N62 C;  5K8E A;  2WDW A;  1WYG A;  5L6G A;  1I19 A;  3TSJ A;  1W1O A;  3C0P A;  3FW9 A;  5I1V A;  3NVV B;  2VFR A;  1JRO A;  2Y3R A;  1VDV A;  1W1J A;  5AWV A;  5D79 A;  1W1S A;  3KJM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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