3G4SW

Co-crystal structure of tiamulin bound to the large ribosomal subunit
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
154
structure length
154
Chain Sequence
MHALVQLRGEVNMHTDIQDTLEMLNIHHVNHCTLVPETDAYRGMVAKVNDFVAFGEPSQETLETVLATRAEPLEGDADVDDEWVAEHTDYDDISGLAFALLSEETTLREQGLSPTLRLHPPRGGHDGVKHPVKEGGQLGKHDTEGIDDLLEAMR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 39
structure length 154
sequence length 154
ec nomenclature
pdb deposition date 2009-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
W PF00327 Ribosomal_L30 Ribosomal protein L30p/L7e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.15.30 Mainly Alpha Orthogonal Bundle 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3g4sW02
3.30.1390.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein L30; Chain: A, Ribosomal protein L30, ferredoxin-like fold domain 3g4sW01
1Q86X 1VQ6W 3CPWV 1VQPW 2ZJPW 1Q82X 3CCSW 5JVHW 1VQMW 1QVFV 1YHQW 5GAGa 3PIPW 4WFAW 5DM6W 1YITW 1NJIX 1KC8X 1Q81X 3CC4W 2QA4W 3CXCV 1K73X 1YJ9W 1KQSV 1YI2W 5GADa 4IO9W 3CCRW 1VQ7W 5DM7W 1YJWW 3G6EW 1VQNW 1Q7YX 1VQLW 3I56W 1K9MX 1W2BV 1VQKW 1JJ2V 4UY8Z 1YIJW 4WFBW 3DLLW 3G71W 4WCEW 2QEXW 4WFNW 1VQ5W 5HL7W 5GAEa 4U67W 3CCLW 3CMAW 3CC7W 1VQ8W 1M1KX 1BXYA 2ZJRW 1N8RX 1S72W 3G4SW 1KD1X 2ZJQW 1YJNW 3I55W 1M90X 4IOCW 3CCJW 5JVGW 3CC2W 3CCUW 3CCVW 3CMEW 1QVGV 1VQ9W 1VQOW 1VQ4W 3CF5W 4WF9W 3PIOW 3CD6W 3CCQW 2OTLW 3OW2V 5GAHa 1K8AX 2OTJW 3J7ZZ 3CCMW 4IOAW 3CCEW
chains in the Genus database with same CATH superfamily
1Q86X 1VQ6W 3CPWV 1LZWA 1VQPW 2ZJPW 3W7UA 3O1FA 1Q82X 3CCSW 5JVHW 1VQMW 1RQSA 4YJMA 1QVFV 3ZG5A 3GQ0A 1YHQW 5GAGa 3PIPW 2WA8A 4YKAA 4WFAW 1R6QC 5DM6W 1YITW 1NJIX 5M18A 1CTFA 1KC8X 1MBUC 1Q81X 3CC4W 3O1FB 2QA4W 2W9RA 3CXCV 2WA9A 1K73X 1YJ9W 1R6OC 1RQUA 1KQSV 5CA3A 1MWRA 1YI2W 5GADa 3W7WA 3ZG0A 4IO9W 1MBXC 3CCRW 1VQ7W 3D3IA 5DM7W 1YJWW 3G6EW 1MWUA 1VQNW 1Q7YX 1VQLW 3I56W 1K9MX 1W2BV 1VQKW 1JJ2V 4UY8Z 1YIJW 4WFBW 3DLLW 3G71W 4WCEW 5M19A 1MWTA 2QEXW 4CJNA 4WFNW 4DKIA 3W7TA 1VQ5W 5HL7W 3G19A 4BL3A 3W7XA 4YJXA 5GAEa 3O2BA 3GW1A 1MG9A 4CPKA 4U67W 3ZFZA 3CCLW 3CMAW 1DD4A 3CC7W 1VQ8W 1M1KX 1BXYA 2ZJRW 1N8RX 1S72W 3G4SW 5M1AA 1KD1X 2ZJQW 1YJNW 3I55W 1DD3A 1M90X 3G3PA 4IOCW 3G1BA 3W7SA 4BL2A 3CCJW 5GW7A 5JVGW 3CC2W 3CCUW 3CCVW 3GQ1A 3CMEW 1QVGV 1VQ9W 1VQOW 1VQ4W 3CF5W 1MBVB 4WF9W 3PIOW 3CD6W 3CCQW 2OTLW 3OW2V 1VQQA 5GAHa 1K8AX 2OTJW 1MWSA 3O2OA 3DNJA 3J7ZZ 3CCMW 4C1NA 1RQVA 4IOAW 3O2HA 3CCEW
chains in the Genus database with same CATH topology
1Q86X 1VQ6W 3CPWV 1VQPW 2ZJPW 1Q82X 3CCSW 5JVHW 1VQMW 1QVFV 1YHQW 5GAGa 3PIPW 4WFAW 5DM6W 1YITW 1NJIX 1KC8X 1Q81X 3CC4W 2QA4W 3CXCV 1K73X 1YJ9W 1KQSV 1YI2W 5GADa 4IO9W 3CCRW 1VQ7W 5DM7W 1YJWW 3G6EW 1VQNW 1Q7YX 1VQLW 3I56W 1K9MX 1W2BV 1VQKW 1JJ2V 4UY8Z 1YIJW 4WFBW 3DLLW 3G71W 4WCEW 2QEXW 4WFNW 1VQ5W 5HL7W 5GAEa 4U67W 3CCLW 3CMAW 3CC7W 1VQ8W 1M1KX 1BXYA 2ZJRW 1N8RX 1S72W 3G4SW 1KD1X 2ZJQW 1YJNW 3I55W 1M90X 4IOCW 3CCJW 5JVGW 3CC2W 3CCUW 3CCVW 3CMEW 1QVGV 1VQ9W 1VQOW 1VQ4W 3CF5W 4WF9W 3PIOW 3CD6W 3CCQW 2OTLW 3OW2V 5GAHa 1K8AX 2OTJW 3J7ZZ 3CCMW 4C1NA 4IOAW 3CCEW
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q86 X;  1VQ6 W;  3CPW V;  1VQP W;  2ZJP W;  1Q82 X;  3CCS W;  5JVH W;  1VQM W;  1QVF V;  1YHQ W;  5GAG a;  3PIP W;  4WFA W;  5DM6 W;  1YIT W;  1NJI X;  1KC8 X;  1Q81 X;  3CC4 W;  2QA4 W;  3CXC V;  1K73 X;  1YJ9 W;  1KQS V;  1YI2 W;  5GAD a;  4IO9 W;  3CCR W;  1VQ7 W;  5DM7 W;  1YJW W;  3G6E W;  1VQN W;  1Q7Y X;  1VQL W;  3I56 W;  1K9M X;  1W2B V;  1VQK W;  1JJ2 V;  4UY8 Z;  1YIJ W;  4WFB W;  3DLL W;  3G71 W;  4WCE W;  2QEX W;  4WFN W;  1VQ5 W;  5HL7 W;  5GAE a;  4U67 W;  3CCL W;  3CMA W;  3CC7 W;  1VQ8 W;  1M1K X;  1BXY A;  2ZJR W;  1N8R X;  1S72 W;  3G4S W;  1KD1 X;  2ZJQ W;  1YJN W;  3I55 W;  1M90 X;  4IOC W;  3CCJ W;  5JVG W;  3CC2 W;  3CCU W;  3CCV W;  3CME W;  1QVG V;  1VQ9 W;  1VQO W;  1VQ4 W;  3CF5 W;  4WF9 W;  3PIO W;  3CD6 W;  3CCQ W;  2OTL W;  3OW2 V;  5GAH a;  1K8A X;  2OTJ W;  3J7Z Z;  3CCM W;  4IOA W;  3CCE W; 
#chains in the Genus database with same CATH topology
 1Q86 X;  1VQ6 W;  3CPW V;  1LZW A;  1VQP W;  2ZJP W;  3W7U A;  3O1F A;  1Q82 X;  3CCS W;  5JVH W;  1VQM W;  1RQS A;  4YJM A;  1QVF V;  3ZG5 A;  3GQ0 A;  1YHQ W;  5GAG a;  3PIP W;  2WA8 A;  4YKA A;  4WFA W;  1R6Q C;  5DM6 W;  1YIT W;  1NJI X;  5M18 A;  1CTF A;  1KC8 X;  1MBU C;  1Q81 X;  3CC4 W;  3O1F B;  2QA4 W;  2W9R A;  3CXC V;  2WA9 A;  1K73 X;  1YJ9 W;  1R6O C;  1RQU A;  1KQS V;  5CA3 A;  1MWR A;  1YI2 W;  5GAD a;  3W7W A;  3ZG0 A;  4IO9 W;  1MBX C;  3CCR W;  1VQ7 W;  3D3I A;  5DM7 W;  1YJW W;  3G6E W;  1MWU A;  1VQN W;  1Q7Y X;  1VQL W;  3I56 W;  1K9M X;  1W2B V;  1VQK W;  1JJ2 V;  4UY8 Z;  1YIJ W;  4WFB W;  3DLL W;  3G71 W;  4WCE W;  5M19 A;  1MWT A;  2QEX W;  4CJN A;  4WFN W;  4DKI A;  3W7T A;  1VQ5 W;  5HL7 W;  3G19 A;  4BL3 A;  3W7X A;  4YJX A;  5GAE a;  3O2B A;  3GW1 A;  1MG9 A;  4CPK A;  4U67 W;  3ZFZ A;  3CCL W;  3CMA W;  1DD4 A;  3CC7 W;  1VQ8 W;  1M1K X;  1BXY A;  2ZJR W;  1N8R X;  1S72 W;  3G4S W;  5M1A A;  1KD1 X;  2ZJQ W;  1YJN W;  3I55 W;  1DD3 A;  1M90 X;  3G3P A;  4IOC W;  3G1B A;  3W7S A;  4BL2 A;  3CCJ W;  5GW7 A;  5JVG W;  3CC2 W;  3CCU W;  3CCV W;  3GQ1 A;  3CME W;  1QVG V;  1VQ9 W;  1VQO W;  1VQ4 W;  3CF5 W;  1MBV B;  4WF9 W;  3PIO W;  3CD6 W;  3CCQ W;  2OTL W;  3OW2 V;  1VQQ A;  5GAH a;  1K8A X;  2OTJ W;  1MWS A;  3O2O A;  3DNJ A;  3J7Z Z;  3CCM W;  4C1N A;  1RQV A;  4IOA W;  3O2H A;  3CCE W; 
#chains in the Genus database with same CATH homology
 1Q86 X;  1VQ6 W;  3CPW V;  1VQP W;  2ZJP W;  1Q82 X;  3CCS W;  5JVH W;  1VQM W;  1QVF V;  1YHQ W;  5GAG a;  3PIP W;  4WFA W;  5DM6 W;  1YIT W;  1NJI X;  1KC8 X;  1Q81 X;  3CC4 W;  2QA4 W;  3CXC V;  1K73 X;  1YJ9 W;  1KQS V;  1YI2 W;  5GAD a;  4IO9 W;  3CCR W;  1VQ7 W;  5DM7 W;  1YJW W;  3G6E W;  1VQN W;  1Q7Y X;  1VQL W;  3I56 W;  1K9M X;  1W2B V;  1VQK W;  1JJ2 V;  4UY8 Z;  1YIJ W;  4WFB W;  3DLL W;  3G71 W;  4WCE W;  2QEX W;  4WFN W;  1VQ5 W;  5HL7 W;  5GAE a;  4U67 W;  3CCL W;  3CMA W;  3CC7 W;  1VQ8 W;  1M1K X;  1BXY A;  2ZJR W;  1N8R X;  1S72 W;  3G4S W;  1KD1 X;  2ZJQ W;  1YJN W;  3I55 W;  1M90 X;  4IOC W;  3CCJ W;  5JVG W;  3CC2 W;  3CCU W;  3CCV W;  3CME W;  1QVG V;  1VQ9 W;  1VQO W;  1VQ4 W;  3CF5 W;  4WF9 W;  3PIO W;  3CD6 W;  3CCQ W;  2OTL W;  3OW2 V;  5GAH a;  1K8A X;  2OTJ W;  3J7Z Z;  3CCM W;  4C1N A;  4IOA W;  3CCE W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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