3G6EE

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 35
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 3g6eE02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 3g6eE01
3CCUE 3CCJE 2OTLE 1JJ2E 5H1SI 3PIOE 3CMEE 1Q7YG 3CCRE 5GAEG 1M90G 4IOAE 2ZJPE 3DLLE 2QEXE 4WFAE 1VQKE 3CCLE 5JVHE 4UY8G 1QVFE 1KQSE 1W2BE 1VQOE 4IO9E 1K73G 5MLCH 3CC4E 1S72E 1Q81G 1VQ6E 3CCME 3J7ZG 5GADG 1K8AG 4U67E 1VQME 1YJWE 5GAHG 2CQLA 1YIJE 1VQ7E 3PIPE 4WCEE 5GAGG 1YJ9E 3CCSE 1VQ5E 3CXCE 1M1KG 1YHQE 3I56E 1KC8G 5DM6E 2QA4E 1VQ8E 3CMAE 3I55E 1VQ4E 1VQ9E 3CCQE 2ZJQE 3CF5E 1VQLE 1Q86G 3G4SE 5DM7E 1QVGE 1YJNE 1VQPE 1KD1G 3CCVE 4WFNE 3CD6E 1NJIG 1RL6A 1VQNE 1YI2E 3G6EE 3OW2E 3CPWE 4IOCE 4WFBE 1K9MG 4WF9E 3CCEE 1YITE 1Q82G 5JVGE 5AN9B 2ZJRE 5HL7E 1N8RG 3G71E 3CC7E 3CC2E 2OTJE
chains in the Genus database with same CATH superfamily
3CCUE 3CCJE 2OTLE 3AUMO 5H1SI 1JJ2E 3PIOE 1P4PA 3CMEE 1Q7YG 3CCRE 5GAEG 1M90G 4IOAE 2ZJPE 3DLLE 2QEXE 4WFAE 1VQKE 3CCLE 5B2AO 5JVHE 4UY8G 1QVFE 2G8CO 1KQSE 1W2BE 1VQOE 4IO9E 1K73G 5MLCH 3CC4E 1S72E 2OL8O 1Q81G 1VQ6E 3CCME 3J7ZG 5B3MO 5GADG 1K8AG 4U67E 1VQME 1YJWE 2I5VO 3IG9A 2I5ZO 2FKJA 5GAHG 1FJ1E 2CQLA 5B11O 1YIJE 1VQ7E 3PIPE 2OY1O 2OY8A 4WCEE 3CKFA 2HKDA 5GAGG 1YJ9E 3CCSE 1RJLC 1VQ5E 3CKGA 2OL6O 3CXCE 1M1KG 5B10O 1YHQE 1OSPO 3I56E 2OL7A 2AF5A 1KC8G 2OY5O 5DM6E 2QA4E 1VQ8E 3CMAE 2PI3O 3I55E 1VQ4E 1VQ9E 3CCQE 2ZJQE 3EC5A 2FKGA 3CF5E 1VQLE 1Q86G 3G4SE 2OY7A 5DM7E 1QVGE 1YJNE 1VQPE 1KD1G 3CCVE 4WFNE 3CD6E 3IGEA 1NJIG 1RL6A 1VQNE 1YI2E 3G6EE 3OW2E 3CPWE 4IOCE 4WFBE 1K9MG 4WF9E 3CCEE 2OYBO 1YITE 1Q82G 5JVGE 5AN9B 2ZJRE 5HL7E 1N8RG 3G71E 3CC7E 3CC2E 2OTJE
chains in the Genus database with same CATH topology
3CCUE 3CCJE 2OTLE 1JJ2E 5H1SI 3PIOE 3CMEE 1Q7YG 3CCRE 5GAEG 1M90G 4IOAE 2ZJPE 3DLLE 2QEXE 4WFAE 1VQKE 3CCLE 5JVHE 4UY8G 1QVFE 1KQSE 1W2BE 1VQOE 4IO9E 1K73G 5MLCH 3CC4E 1S72E 1Q81G 1VQ6E 3CCME 3J7ZG 5GADG 1K8AG 4U67E 1VQME 1YJWE 5GAHG 2CQLA 1YIJE 1VQ7E 3PIPE 4WCEE 5GAGG 1YJ9E 3CCSE 1VQ5E 3CXCE 1M1KG 1YHQE 3I56E 1KC8G 5DM6E 2QA4E 1VQ8E 3CMAE 3I55E 1VQ4E 1VQ9E 3CCQE 2ZJQE 3CF5E 1VQLE 1Q86G 3G4SE 5DM7E 1QVGE 1YJNE 1VQPE 1KD1G 3CCVE 4WFNE 3CD6E 1NJIG 1RL6A 1VQNE 1YI2E 3G6EE 3OW2E 3CPWE 4IOCE 4WFBE 1K9MG 4WF9E 3CCEE 1YITE 1Q82G 5JVGE 5AN9B 2ZJRE 5HL7E 1N8RG 3G71E 3CC7E 3CC2E 2OTJE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CCU E;  3CCJ E;  2OTL E;  1JJ2 E;  5H1S I;  3PIO E;  3CME E;  1Q7Y G;  3CCR E;  5GAE G;  1M90 G;  4IOA E;  2ZJP E;  3DLL E;  2QEX E;  4WFA E;  1VQK E;  3CCL E;  5JVH E;  4UY8 G;  1QVF E;  1KQS E;  1W2B E;  1VQO E;  4IO9 E;  1K73 G;  5MLC H;  3CC4 E;  1S72 E;  1Q81 G;  1VQ6 E;  3CCM E;  3J7Z G;  5GAD G;  1K8A G;  4U67 E;  1VQM E;  1YJW E;  5GAH G;  2CQL A;  1YIJ E;  1VQ7 E;  3PIP E;  4WCE E;  5GAG G;  1YJ9 E;  3CCS E;  1VQ5 E;  3CXC E;  1M1K G;  1YHQ E;  3I56 E;  1KC8 G;  5DM6 E;  2QA4 E;  1VQ8 E;  3CMA E;  3I55 E;  1VQ4 E;  1VQ9 E;  3CCQ E;  2ZJQ E;  3CF5 E;  1VQL E;  1Q86 G;  3G4S E;  5DM7 E;  1QVG E;  1YJN E;  1VQP E;  1KD1 G;  3CCV E;  4WFN E;  3CD6 E;  1NJI G;  1RL6 A;  1VQN E;  1YI2 E;  3G6E E;  3OW2 E;  3CPW E;  4IOC E;  4WFB E;  1K9M G;  4WF9 E;  3CCE E;  1YIT E;  1Q82 G;  5JVG E;  5AN9 B;  2ZJR E;  5HL7 E;  1N8R G;  3G71 E;  3CC7 E;  3CC2 E;  2OTJ E; 
#chains in the Genus database with same CATH topology
 3CCU E;  3CCJ E;  2OTL E;  3AUM O;  5H1S I;  1JJ2 E;  3PIO E;  1P4P A;  3CME E;  1Q7Y G;  3CCR E;  5GAE G;  1M90 G;  4IOA E;  2ZJP E;  3DLL E;  2QEX E;  4WFA E;  1VQK E;  3CCL E;  5B2A O;  5JVH E;  4UY8 G;  1QVF E;  2G8C O;  1KQS E;  1W2B E;  1VQO E;  4IO9 E;  1K73 G;  5MLC H;  3CC4 E;  1S72 E;  2OL8 O;  1Q81 G;  1VQ6 E;  3CCM E;  3J7Z G;  5B3M O;  5GAD G;  1K8A G;  4U67 E;  1VQM E;  1YJW E;  2I5V O;  3IG9 A;  2I5Z O;  2FKJ A;  5GAH G;  1FJ1 E;  2CQL A;  5B11 O;  1YIJ E;  1VQ7 E;  3PIP E;  2OY1 O;  2OY8 A;  4WCE E;  3CKF A;  2HKD A;  5GAG G;  1YJ9 E;  3CCS E;  1RJL C;  1VQ5 E;  3CKG A;  2OL6 O;  3CXC E;  1M1K G;  5B10 O;  1YHQ E;  1OSP O;  3I56 E;  2OL7 A;  2AF5 A;  1KC8 G;  2OY5 O;  5DM6 E;  2QA4 E;  1VQ8 E;  3CMA E;  2PI3 O;  3I55 E;  1VQ4 E;  1VQ9 E;  3CCQ E;  2ZJQ E;  3EC5 A;  2FKG A;  3CF5 E;  1VQL E;  1Q86 G;  3G4S E;  2OY7 A;  5DM7 E;  1QVG E;  1YJN E;  1VQP E;  1KD1 G;  3CCV E;  4WFN E;  3CD6 E;  3IGE A;  1NJI G;  1RL6 A;  1VQN E;  1YI2 E;  3G6E E;  3OW2 E;  3CPW E;  4IOC E;  4WFB E;  1K9M G;  4WF9 E;  3CCE E;  2OYB O;  1YIT E;  1Q82 G;  5JVG E;  5AN9 B;  2ZJR E;  5HL7 E;  1N8R G;  3G71 E;  3CC7 E;  3CC2 E;  2OTJ E; 
#chains in the Genus database with same CATH homology
 3CCU E;  3CCJ E;  2OTL E;  1JJ2 E;  5H1S I;  3PIO E;  3CME E;  1Q7Y G;  3CCR E;  5GAE G;  1M90 G;  4IOA E;  2ZJP E;  3DLL E;  2QEX E;  4WFA E;  1VQK E;  3CCL E;  5JVH E;  4UY8 G;  1QVF E;  1KQS E;  1W2B E;  1VQO E;  4IO9 E;  1K73 G;  5MLC H;  3CC4 E;  1S72 E;  1Q81 G;  1VQ6 E;  3CCM E;  3J7Z G;  5GAD G;  1K8A G;  4U67 E;  1VQM E;  1YJW E;  5GAH G;  2CQL A;  1YIJ E;  1VQ7 E;  3PIP E;  4WCE E;  5GAG G;  1YJ9 E;  3CCS E;  1VQ5 E;  3CXC E;  1M1K G;  1YHQ E;  3I56 E;  1KC8 G;  5DM6 E;  2QA4 E;  1VQ8 E;  3CMA E;  3I55 E;  1VQ4 E;  1VQ9 E;  3CCQ E;  2ZJQ E;  3CF5 E;  1VQL E;  1Q86 G;  3G4S E;  5DM7 E;  1QVG E;  1YJN E;  1VQP E;  1KD1 G;  3CCV E;  4WFN E;  3CD6 E;  1NJI G;  1RL6 A;  1VQN E;  1YI2 E;  3G6E E;  3OW2 E;  3CPW E;  4IOC E;  4WFB E;  1K9M G;  4WF9 E;  3CCE E;  1YIT E;  1Q82 G;  5JVG E;  5AN9 B;  2ZJR E;  5HL7 E;  1N8R G;  3G71 E;  3CC7 E;  3CC2 E;  2OTJ E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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