3G6EW

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
154
structure length
154
Chain Sequence
MHALVQLRGEVNMHTDIQDTLEMLNIHHVNHCTLVPETDAYRGMVAKVNDFVAFGEPSQETLETVLATRAEPLEGDADVDDEWVAEHTDYDDISGLAFALLSEETTLREQGLSPTLRLHPPRGGHDGVKHPVKEGGQLGKHDTEGIDDLLEAMR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 50
structure length 154
sequence length 154
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
W PF00327 Ribosomal_L30 Ribosomal protein L30p/L7e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.15.30 Mainly Alpha Orthogonal Bundle 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3g6eW02
3.30.1390.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein L30; Chain: A, Ribosomal protein L30, ferredoxin-like fold domain 3g6eW01
1QVFV 1K73X 1YIJW 5GADa 3CD6W 1YJ9W 3I55W 3G71W 5DM7W 1M90X 3G6EW 4WCEW 1VQ9W 4U67W 1QVGV 4IOAW 3I56W 2ZJRW 5JVGW 3CC7W 1JJ2V 3CCRW 1Q86X 4UY8Z 1VQKW 3CMEW 1YITW 1Q82X 1K8AX 1YJWW 2ZJPW 1S72W 3CCVW 3CCLW 1VQ5W 3CCUW 2OTLW 1VQNW 3PIPW 1VQ8W 5DM6W 3CCQW 4WFNW 1W2BV 3CPWV 3CC4W 1BXYA 3CCEW 1YI2W 4IO9W 1YHQW 4WFAW 2OTJW 3CCMW 5GAGa 5HL7W 1Q81X 3G4SW 3CC2W 1VQMW 2QEXW 1M1KX 1VQPW 4IOCW 3CF5W 2QA4W 1KC8X 1VQ4W 1VQOW 4WF9W 1N8RX 1K9MX 2ZJQW 1Q7YX 1VQLW 1KQSV 1NJIX 3CCJW 3OW2V 3DLLW 3CMAW 4WFBW 3PIOW 5GAEa 5GAHa 3CCSW 3J7ZZ 1KD1X 3CXCV 1YJNW 5JVHW 1VQ7W 1VQ6W
chains in the Genus database with same CATH superfamily
1QVFV 1K73X 4YJMA 1YIJW 5GADa 1MWSA 3CD6W 1YJ9W 3W7TA 3I55W 1RQSA 4YKAA 3G71W 5DM7W 1M90X 3D3IA 3GW1A 3G6EW 4WCEW 1VQ9W 4U67W 1QVGV 4IOAW 3I56W 2ZJRW 5M1AA 5JVGW 3CC7W 1JJ2V 3CCRW 1Q86X 2WA9A 3GQ1A 4UY8Z 5M18A 1VQKW 3CMEW 1YITW 1Q82X 3O2BA 3W7WA 1K8AX 1YJWW 4C1NA 2ZJPW 1S72W 3CCVW 3CCLW 1VQ5W 1R6OC 3CCUW 2W9RA 2OTLW 1VQNW 3PIPW 3O2OA 3W7SA 1VQ8W 5DM6W 1RQVA 3CCQW 3O1FB 4WFNW 1W2BV 4BL2A 3CPWV 3CC4W 3O2HA 1BXYA 3CCEW 1MG9A 1YI2W 4IO9W 1YHQW 4WFAW 1LZWA 2OTJW 2WA8A 3ZG0A 1RQUA 5GW7A 1DD4A 3CCMW 5GAGa 3GQ0A 5HL7W 3ZG5A 1Q81X 3G4SW 3CC2W 1VQMW 5M19A 1VQQA 1R6QC 2QEXW 1MWRA 1M1KX 1VQPW 4IOCW 3CF5W 1MBUC 2QA4W 3DNJA 1KC8X 1MBXC 1VQ4W 1VQOW 4WF9W 1MBVB 1N8RX 1DD3A 1K9MX 2ZJQW 1Q7YX 1VQLW 1CTFA 1MWUA 3G3PA 1KQSV 3G1BA 4YJXA 1NJIX 3CCJW 3OW2V 4BL3A 3DLLW 3CMAW 4WFBW 3O1FA 5GAEa 5GAHa 3PIOW 3CCSW 3J7ZZ 3W7XA 4DKIA 4CJNA 3W7UA 3ZFZA 4CPKA 1KD1X 3CXCV 1YJNW 5CA3A 1VQ7W 3G19A 5JVHW 1MWTA 1VQ6W
chains in the Genus database with same CATH topology
1QVFV 1K73X 1YIJW 5GADa 3CD6W 1YJ9W 3I55W 3G71W 5DM7W 1M90X 3G6EW 4WCEW 1VQ9W 4U67W 1QVGV 4IOAW 3I56W 2ZJRW 5JVGW 3CC7W 1JJ2V 3CCRW 1Q86X 4UY8Z 1VQKW 3CMEW 1YITW 1Q82X 1K8AX 1YJWW 4C1NA 2ZJPW 1S72W 3CCVW 3CCLW 1VQ5W 3CCUW 2OTLW 1VQNW 3PIPW 1VQ8W 5DM6W 3CCQW 4WFNW 1W2BV 3CPWV 3CC4W 1BXYA 3CCEW 1YI2W 4IO9W 1YHQW 4WFAW 2OTJW 3CCMW 5GAGa 5HL7W 1Q81X 3G4SW 3CC2W 1VQMW 2QEXW 1M1KX 1VQPW 4IOCW 3CF5W 2QA4W 1KC8X 1VQ4W 1VQOW 4WF9W 1N8RX 1K9MX 2ZJQW 1Q7YX 1VQLW 1KQSV 1NJIX 3CCJW 3OW2V 3DLLW 3CMAW 4WFBW 3PIOW 5GAEa 5GAHa 3CCSW 3J7ZZ 1KD1X 3CXCV 1YJNW 5JVHW 1VQ7W 1VQ6W
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QVF V;  1K73 X;  1YIJ W;  5GAD a;  3CD6 W;  1YJ9 W;  3I55 W;  3G71 W;  5DM7 W;  1M90 X;  3G6E W;  4WCE W;  1VQ9 W;  4U67 W;  1QVG V;  4IOA W;  3I56 W;  2ZJR W;  5JVG W;  3CC7 W;  1JJ2 V;  3CCR W;  1Q86 X;  4UY8 Z;  1VQK W;  3CME W;  1YIT W;  1Q82 X;  1K8A X;  1YJW W;  2ZJP W;  1S72 W;  3CCV W;  3CCL W;  1VQ5 W;  3CCU W;  2OTL W;  1VQN W;  3PIP W;  1VQ8 W;  5DM6 W;  3CCQ W;  4WFN W;  1W2B V;  3CPW V;  3CC4 W;  1BXY A;  3CCE W;  1YI2 W;  4IO9 W;  1YHQ W;  4WFA W;  2OTJ W;  3CCM W;  5GAG a;  5HL7 W;  1Q81 X;  3G4S W;  3CC2 W;  1VQM W;  2QEX W;  1M1K X;  1VQP W;  4IOC W;  3CF5 W;  2QA4 W;  1KC8 X;  1VQ4 W;  1VQO W;  4WF9 W;  1N8R X;  1K9M X;  2ZJQ W;  1Q7Y X;  1VQL W;  1KQS V;  1NJI X;  3CCJ W;  3OW2 V;  3DLL W;  3CMA W;  4WFB W;  3PIO W;  5GAE a;  5GAH a;  3CCS W;  3J7Z Z;  1KD1 X;  3CXC V;  1YJN W;  5JVH W;  1VQ7 W;  1VQ6 W; 
#chains in the Genus database with same CATH topology
 1QVF V;  1K73 X;  4YJM A;  1YIJ W;  5GAD a;  1MWS A;  3CD6 W;  1YJ9 W;  3W7T A;  3I55 W;  1RQS A;  4YKA A;  3G71 W;  5DM7 W;  1M90 X;  3D3I A;  3GW1 A;  3G6E W;  4WCE W;  1VQ9 W;  4U67 W;  1QVG V;  4IOA W;  3I56 W;  2ZJR W;  5M1A A;  5JVG W;  3CC7 W;  1JJ2 V;  3CCR W;  1Q86 X;  2WA9 A;  3GQ1 A;  4UY8 Z;  5M18 A;  1VQK W;  3CME W;  1YIT W;  1Q82 X;  3O2B A;  3W7W A;  1K8A X;  1YJW W;  4C1N A;  2ZJP W;  1S72 W;  3CCV W;  3CCL W;  1VQ5 W;  1R6O C;  3CCU W;  2W9R A;  2OTL W;  1VQN W;  3PIP W;  3O2O A;  3W7S A;  1VQ8 W;  5DM6 W;  1RQV A;  3CCQ W;  3O1F B;  4WFN W;  1W2B V;  4BL2 A;  3CPW V;  3CC4 W;  3O2H A;  1BXY A;  3CCE W;  1MG9 A;  1YI2 W;  4IO9 W;  1YHQ W;  4WFA W;  1LZW A;  2OTJ W;  2WA8 A;  3ZG0 A;  1RQU A;  5GW7 A;  1DD4 A;  3CCM W;  5GAG a;  3GQ0 A;  5HL7 W;  3ZG5 A;  1Q81 X;  3G4S W;  3CC2 W;  1VQM W;  5M19 A;  1VQQ A;  1R6Q C;  2QEX W;  1MWR A;  1M1K X;  1VQP W;  4IOC W;  3CF5 W;  1MBU C;  2QA4 W;  3DNJ A;  1KC8 X;  1MBX C;  1VQ4 W;  1VQO W;  4WF9 W;  1MBV B;  1N8R X;  1DD3 A;  1K9M X;  2ZJQ W;  1Q7Y X;  1VQL W;  1CTF A;  1MWU A;  3G3P A;  1KQS V;  3G1B A;  4YJX A;  1NJI X;  3CCJ W;  3OW2 V;  4BL3 A;  3DLL W;  3CMA W;  4WFB W;  3O1F A;  5GAE a;  5GAH a;  3PIO W;  3CCS W;  3J7Z Z;  3W7X A;  4DKI A;  4CJN A;  3W7U A;  3ZFZ A;  4CPK A;  1KD1 X;  3CXC V;  1YJN W;  5CA3 A;  1VQ7 W;  3G19 A;  5JVH W;  1MWT A;  1VQ6 W; 
#chains in the Genus database with same CATH homology
 1QVF V;  1K73 X;  1YIJ W;  5GAD a;  3CD6 W;  1YJ9 W;  3I55 W;  3G71 W;  5DM7 W;  1M90 X;  3G6E W;  4WCE W;  1VQ9 W;  4U67 W;  1QVG V;  4IOA W;  3I56 W;  2ZJR W;  5JVG W;  3CC7 W;  1JJ2 V;  3CCR W;  1Q86 X;  4UY8 Z;  1VQK W;  3CME W;  1YIT W;  1Q82 X;  1K8A X;  1YJW W;  4C1N A;  2ZJP W;  1S72 W;  3CCV W;  3CCL W;  1VQ5 W;  3CCU W;  2OTL W;  1VQN W;  3PIP W;  1VQ8 W;  5DM6 W;  3CCQ W;  4WFN W;  1W2B V;  3CPW V;  3CC4 W;  1BXY A;  3CCE W;  1YI2 W;  4IO9 W;  1YHQ W;  4WFA W;  2OTJ W;  3CCM W;  5GAG a;  5HL7 W;  1Q81 X;  3G4S W;  3CC2 W;  1VQM W;  2QEX W;  1M1K X;  1VQP W;  4IOC W;  3CF5 W;  2QA4 W;  1KC8 X;  1VQ4 W;  1VQO W;  4WF9 W;  1N8R X;  1K9M X;  2ZJQ W;  1Q7Y X;  1VQL W;  1KQS V;  1NJI X;  3CCJ W;  3OW2 V;  3DLL W;  3CMA W;  4WFB W;  3PIO W;  5GAE a;  5GAH a;  3CCS W;  3J7Z Z;  1KD1 X;  3CXC V;  1YJN W;  5JVH W;  1VQ7 W;  1VQ6 W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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