3HH7A

Structural and functional characterization of a novel homodimeric three-finger neurotoxin from the venom of ophiophagus hannah (king cobra)
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
65
structure length
65
Chain Sequence
TKCYNHQSTTPETTEICPDSGYFCYKSSWIDGREGRIERGCTFTCPELTPNGKYVYCCRRDKCNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)
pubmed doi rcsb
molecule tags Toxin
molecule keywords Muscarinic toxin-like protein 3 homolog
total genus 12
structure length 65
sequence length 65
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-05-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00087 Toxin_TOLIP Snake toxin and toxin-like protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.60.10 Mainly Beta Ribbon CD59 CD59 3hh7A00
4OM5A 2J8BA 2MHYA 5IMTD 1FF4A 1NYUA 1HAAA 1I02A 1S4YA 1KFHA 2FD6U 2GOOC 2H64C 2X8BB 1CDTA 1XT3A 3BT1U 2VLWA 1FFJA 1BTEA 2H5FA 5DU1A 1M9ZA 2LA1A 2MJ4A 1CODA 2QJAC 1KC4A 4RUDA 1TXBA 2ERAA 1NEAA 1DRSA 1ABTA 1VB0A 2H7ZA 2UWRA 1QM7A 4BDTB 2QC1A 3EVSC 2MUOA 1H0JA 3PLCA 1CXOA 2HLRA 1IDHA 1F94A 1FSCA 2MUPA 1CREA 1TGXA 3KFDI 2MJYA 3U74U 1LXHA 1IQ9A 1CXNA 2NBTA 1IJCA 1KBSA 1CDQA 1B41B 2QJ9C 1CTXA 1HAJA 1ZADA 2CCXA 4P7UA 2N99A 1L4WA 1IDLA 1JE9A 1FASA 1IDGA 1HOYA 2ABXA 2K3GA 3NDSA 2CRTA 4FAOC 2H7ZB 1LX5B 4FAOE 2H62D 3ERAA 2OFSA 2I9BE 1BXPA 1G6MA 1KS6A 1KU6B 3LAQU 2JVEA 4DO8A 1MR6A 1FRAA 1LJZA 6EBXA 1COEA 5IMYC 1NTXA 1NTNA 2MJ0A 1CRFA 1MAHF 2CRSA 1V6PA 1ONJA 2MFAA 1TFSA 1IKCA 1RGJA 1PLOA 1JGKA 1YWHA 4BIKB 1JBDA 2PJYB 4XJJA 3NH7A 1NXBA 1F8UB 1IDIA 2H8UA 3U73U 1IK8A 4ZQYA 1CDRA 1UG4A 1RL5A 1ES7B 3BT2U 2UX2A 4QTIU 2L5SA 2BHIA 2L03A 4LFTA 3QB4B 3KFDE 2BTXA 1QKDA 1CDSA 3HH7A 1NORA 5EBXA 1KBAA 1W6BA 4IYEA 1CHVS 1HC9A 1NYSA 1KXIA 2PJYC 2CDXA 1CCQA 1HC9B 3EBXA 1TXAA 1CVOA 4OM4A 4UY2C 1KTZB 2JQPA 1KBTA 1FSSB 2CTXA 5DO6A 1QKEA 5DZ5A 4EY8B 1CB9A 1LSIA 3NEQA 1LXGA 1ERAA 2HLQA 2GOOB 3VTSA 2H64B 2LCRA 3FEVA 1ERGA 1REWC 1KL8A 2H62C 2QJBC 4AEAA 4HQPF
chains in the Genus database with same CATH superfamily
4OM5A 2J8BA 2MHYA 5IMTD 1FF4A 1NYUA 1HAAA 1I02A 1S4YA 1KFHA 2FD6U 2GOOC 2H64C 2X8BB 1CDTA 1XT3A 3BT1U 2VLWA 1FFJA 1BTEA 2H5FA 5DU1A 1M9ZA 2LA1A 2MJ4A 1CODA 2QJAC 1KC4A 4RUDA 1TXBA 2ERAA 1NEAA 1DRSA 1ABTA 1VB0A 2H7ZA 2UWRA 1QM7A 4BDTB 2QC1A 3EVSC 2MUOA 1H0JA 3PLCA 1CXOA 2HLRA 1IDHA 1F94A 1FSCA 2MUPA 1CREA 1TGXA 3KFDI 2MJYA 3U74U 1LXHA 1IQ9A 1CXNA 2NBTA 1IJCA 1KBSA 1CDQA 1B41B 2QJ9C 1CTXA 1HAJA 1ZADA 2CCXA 4P7UA 2N99A 1L4WA 1IDLA 1JE9A 1FASA 1IDGA 1HOYA 2ABXA 2K3GA 3NDSA 2CRTA 4FAOC 2H7ZB 1LX5B 4KSNA 4FAOE 2H62D 3ERAA 2OFSA 2I9BE 1BXPA 1G6MA 1KS6A 1KU6B 3LAQU 2JVEA 4DO8A 1MR6A 1FRAA 1LJZA 6EBXA 1COEA 5IMYC 1NTXA 1NTNA 2MJ0A 1CRFA 1MAHF 2CRSA 1V6PA 1ONJA 2MFAA 1TFSA 1IKCA 1RGJA 1PLOA 1JGKA 1YWHA 4BIKB 1JBDA 2PJYB 4XJJA 3NH7A 1NXBA 1F8UB 1IDIA 2H8UA 3U73U 1IK8A 4ZQYA 1CDRA 1UG4A 1RL5A 1ES7B 3BT2U 2UX2A 4QTIU 2L5SA 2BHIA 2L03A 4LFTA 3QB4B 3KFDE 2BTXA 1QKDA 1CDSA 3HH7A 1NORA 5EBXA 1KBAA 1W6BA 4IYEA 1CHVS 1HC9A 1NYSA 1KXIA 2PJYC 2CDXA 1CCQA 1HC9B 3EBXA 1TXAA 1CVOA 4OM4A 4UY2C 1KTZB 2JQPA 1KBTA 1FSSB 2CTXA 5DO6A 1QKEA 5DZ5A 4EY8B 1CB9A 1LSIA 3NEQA 1LXGA 1ERAA 2HLQA 2GOOB 3VTSA 2H64B 2LCRA 3FEVA 1ERGA 1REWC 1KL8A 2H62C 2QJBC 4AEAA 4HQPF
chains in the Genus database with same CATH topology
4OM5A 2J8BA 2MHYA 5IMTD 1FF4A 1NYUA 1HAAA 1I02A 1S4YA 1KFHA 2FD6U 2GOOC 2H64C 2X8BB 1CDTA 1XT3A 3BT1U 2VLWA 1FFJA 1BTEA 2H5FA 5DU1A 1M9ZA 2LA1A 2MJ4A 1CODA 2QJAC 1KC4A 4RUDA 1TXBA 2ERAA 1NEAA 1DRSA 1ABTA 1VB0A 2H7ZA 2UWRA 1QM7A 4BDTB 2QC1A 3EVSC 2MUOA 1H0JA 3PLCA 1CXOA 2HLRA 1IDHA 1F94A 1FSCA 2MUPA 1CREA 1TGXA 3KFDI 2MJYA 3U74U 1LXHA 1IQ9A 1CXNA 2NBTA 1IJCA 1KBSA 1CDQA 1B41B 2QJ9C 1CTXA 1HAJA 1ZADA 2CCXA 4P7UA 2N99A 1L4WA 1IDLA 1JE9A 1FASA 1IDGA 1HOYA 2ABXA 2K3GA 3NDSA 2CRTA 4FAOC 2H7ZB 1LX5B 4KSNA 4FAOE 2H62D 3ERAA 2OFSA 2I9BE 1BXPA 1G6MA 1KS6A 1KU6B 3LAQU 2JVEA 4DO8A 1MR6A 1FRAA 1LJZA 6EBXA 1COEA 5IMYC 1NTXA 1NTNA 2MJ0A 1CRFA 1MAHF 2CRSA 1V6PA 1ONJA 2MFAA 1TFSA 1IKCA 1RGJA 1PLOA 1JGKA 1YWHA 4BIKB 1JBDA 2PJYB 4XJJA 3NH7A 1NXBA 1F8UB 1IDIA 2H8UA 3U73U 1IK8A 4ZQYA 1CDRA 1UG4A 1RL5A 1ES7B 3BT2U 2UX2A 4QTIU 2L5SA 2BHIA 2L03A 4LFTA 3QB4B 3KFDE 2BTXA 1QKDA 1CDSA 3HH7A 1NORA 5EBXA 1KBAA 1W6BA 4IYEA 1CHVS 1HC9A 1NYSA 1KXIA 2PJYC 2CDXA 1CCQA 1HC9B 3EBXA 1TXAA 1CVOA 4OM4A 4UY2C 1KTZB 2JQPA 1KBTA 1FSSB 2CTXA 5DO6A 1QKEA 5DZ5A 4EY8B 1CB9A 1LSIA 3NEQA 1LXGA 1ERAA 2HLQA 2GOOB 3VTSA 2H64B 2LCRA 3FEVA 1ERGA 1REWC 1KL8A 2H62C 2QJBC 4AEAA 4HQPF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OM5 A;  2J8B A;  2MHY A;  5IMT D;  1FF4 A;  1NYU A;  1HAA A;  1I02 A;  1S4Y A;  1KFH A;  2FD6 U;  2GOO C;  2H64 C;  2X8B B;  1CDT A;  1XT3 A;  3BT1 U;  2VLW A;  1FFJ A;  1BTE A;  2H5F A;  5DU1 A;  1M9Z A;  2LA1 A;  2MJ4 A;  1COD A;  2QJA C;  1KC4 A;  4RUD A;  1TXB A;  2ERA A;  1NEA A;  1DRS A;  1ABT A;  1VB0 A;  2H7Z A;  2UWR A;  1QM7 A;  4BDT B;  2QC1 A;  3EVS C;  2MUO A;  1H0J A;  3PLC A;  1CXO A;  2HLR A;  1IDH A;  1F94 A;  1FSC A;  2MUP A;  1CRE A;  1TGX A;  3KFD I;  2MJY A;  3U74 U;  1LXH A;  1IQ9 A;  1CXN A;  2NBT A;  1IJC A;  1KBS A;  1CDQ A;  1B41 B;  2QJ9 C;  1CTX A;  1HAJ A;  1ZAD A;  2CCX A;  4P7U A;  2N99 A;  1L4W A;  1IDL A;  1JE9 A;  1FAS A;  1IDG A;  1HOY A;  2ABX A;  2K3G A;  3NDS A;  2CRT A;  4FAO C;  2H7Z B;  1LX5 B;  4FAO E;  2H62 D;  3ERA A;  2OFS A;  2I9B E;  1BXP A;  1G6M A;  1KS6 A;  1KU6 B;  3LAQ U;  2JVE A;  4DO8 A;  1MR6 A;  1FRA A;  1LJZ A;  6EBX A;  1COE A;  5IMY C;  1NTX A;  1NTN A;  2MJ0 A;  1CRF A;  1MAH F;  2CRS A;  1V6P A;  1ONJ A;  2MFA A;  1TFS A;  1IKC A;  1RGJ A;  1PLO A;  1JGK A;  1YWH A;  4BIK B;  1JBD A;  2PJY B;  4XJJ A;  3NH7 A;  1NXB A;  1F8U B;  1IDI A;  2H8U A;  3U73 U;  1IK8 A;  4ZQY A;  1CDR A;  1UG4 A;  1RL5 A;  1ES7 B;  3BT2 U;  2UX2 A;  4QTI U;  2L5S A;  2BHI A;  2L03 A;  4LFT A;  3QB4 B;  3KFD E;  2BTX A;  1QKD A;  1CDS A;  3HH7 A;  1NOR A;  5EBX A;  1KBA A;  1W6B A;  4IYE A;  1CHV S;  1HC9 A;  1NYS A;  1KXI A;  2PJY C;  2CDX A;  1CCQ A;  1HC9 B;  3EBX A;  1TXA A;  1CVO A;  4OM4 A;  4UY2 C;  1KTZ B;  2JQP A;  1KBT A;  1FSS B;  2CTX A;  5DO6 A;  1QKE A;  5DZ5 A;  4EY8 B;  1CB9 A;  1LSI A;  3NEQ A;  1LXG A;  1ERA A;  2HLQ A;  2GOO B;  3VTS A;  2H64 B;  2LCR A;  3FEV A;  1ERG A;  1REW C;  1KL8 A;  2H62 C;  2QJB C;  4AEA A;  4HQP F; 
#chains in the Genus database with same CATH topology
 4OM5 A;  2J8B A;  2MHY A;  5IMT D;  1FF4 A;  1NYU A;  1HAA A;  1I02 A;  1S4Y A;  1KFH A;  2FD6 U;  2GOO C;  2H64 C;  2X8B B;  1CDT A;  1XT3 A;  3BT1 U;  2VLW A;  1FFJ A;  1BTE A;  2H5F A;  5DU1 A;  1M9Z A;  2LA1 A;  2MJ4 A;  1COD A;  2QJA C;  1KC4 A;  4RUD A;  1TXB A;  2ERA A;  1NEA A;  1DRS A;  1ABT A;  1VB0 A;  2H7Z A;  2UWR A;  1QM7 A;  4BDT B;  2QC1 A;  3EVS C;  2MUO A;  1H0J A;  3PLC A;  1CXO A;  2HLR A;  1IDH A;  1F94 A;  1FSC A;  2MUP A;  1CRE A;  1TGX A;  3KFD I;  2MJY A;  3U74 U;  1LXH A;  1IQ9 A;  1CXN A;  2NBT A;  1IJC A;  1KBS A;  1CDQ A;  1B41 B;  2QJ9 C;  1CTX A;  1HAJ A;  1ZAD A;  2CCX A;  4P7U A;  2N99 A;  1L4W A;  1IDL A;  1JE9 A;  1FAS A;  1IDG A;  1HOY A;  2ABX A;  2K3G A;  3NDS A;  2CRT A;  4FAO C;  2H7Z B;  1LX5 B;  4KSN A;  4FAO E;  2H62 D;  3ERA A;  2OFS A;  2I9B E;  1BXP A;  1G6M A;  1KS6 A;  1KU6 B;  3LAQ U;  2JVE A;  4DO8 A;  1MR6 A;  1FRA A;  1LJZ A;  6EBX A;  1COE A;  5IMY C;  1NTX A;  1NTN A;  2MJ0 A;  1CRF A;  1MAH F;  2CRS A;  1V6P A;  1ONJ A;  2MFA A;  1TFS A;  1IKC A;  1RGJ A;  1PLO A;  1JGK A;  1YWH A;  4BIK B;  1JBD A;  2PJY B;  4XJJ A;  3NH7 A;  1NXB A;  1F8U B;  1IDI A;  2H8U A;  3U73 U;  1IK8 A;  4ZQY A;  1CDR A;  1UG4 A;  1RL5 A;  1ES7 B;  3BT2 U;  2UX2 A;  4QTI U;  2L5S A;  2BHI A;  2L03 A;  4LFT A;  3QB4 B;  3KFD E;  2BTX A;  1QKD A;  1CDS A;  3HH7 A;  1NOR A;  5EBX A;  1KBA A;  1W6B A;  4IYE A;  1CHV S;  1HC9 A;  1NYS A;  1KXI A;  2PJY C;  2CDX A;  1CCQ A;  1HC9 B;  3EBX A;  1TXA A;  1CVO A;  4OM4 A;  4UY2 C;  1KTZ B;  2JQP A;  1KBT A;  1FSS B;  2CTX A;  5DO6 A;  1QKE A;  5DZ5 A;  4EY8 B;  1CB9 A;  1LSI A;  3NEQ A;  1LXG A;  1ERA A;  2HLQ A;  2GOO B;  3VTS A;  2H64 B;  2LCR A;  3FEV A;  1ERG A;  1REW C;  1KL8 A;  2H62 C;  2QJB C;  4AEA A;  4HQP F; 
#chains in the Genus database with same CATH homology
 4OM5 A;  2J8B A;  2MHY A;  5IMT D;  1FF4 A;  1NYU A;  1HAA A;  1I02 A;  1S4Y A;  1KFH A;  2FD6 U;  2GOO C;  2H64 C;  2X8B B;  1CDT A;  1XT3 A;  3BT1 U;  2VLW A;  1FFJ A;  1BTE A;  2H5F A;  5DU1 A;  1M9Z A;  2LA1 A;  2MJ4 A;  1COD A;  2QJA C;  1KC4 A;  4RUD A;  1TXB A;  2ERA A;  1NEA A;  1DRS A;  1ABT A;  1VB0 A;  2H7Z A;  2UWR A;  1QM7 A;  4BDT B;  2QC1 A;  3EVS C;  2MUO A;  1H0J A;  3PLC A;  1CXO A;  2HLR A;  1IDH A;  1F94 A;  1FSC A;  2MUP A;  1CRE A;  1TGX A;  3KFD I;  2MJY A;  3U74 U;  1LXH A;  1IQ9 A;  1CXN A;  2NBT A;  1IJC A;  1KBS A;  1CDQ A;  1B41 B;  2QJ9 C;  1CTX A;  1HAJ A;  1ZAD A;  2CCX A;  4P7U A;  2N99 A;  1L4W A;  1IDL A;  1JE9 A;  1FAS A;  1IDG A;  1HOY A;  2ABX A;  2K3G A;  3NDS A;  2CRT A;  4FAO C;  2H7Z B;  1LX5 B;  4KSN A;  4FAO E;  2H62 D;  3ERA A;  2OFS A;  2I9B E;  1BXP A;  1G6M A;  1KS6 A;  1KU6 B;  3LAQ U;  2JVE A;  4DO8 A;  1MR6 A;  1FRA A;  1LJZ A;  6EBX A;  1COE A;  5IMY C;  1NTX A;  1NTN A;  2MJ0 A;  1CRF A;  1MAH F;  2CRS A;  1V6P A;  1ONJ A;  2MFA A;  1TFS A;  1IKC A;  1RGJ A;  1PLO A;  1JGK A;  1YWH A;  4BIK B;  1JBD A;  2PJY B;  4XJJ A;  3NH7 A;  1NXB A;  1F8U B;  1IDI A;  2H8U A;  3U73 U;  1IK8 A;  4ZQY A;  1CDR A;  1UG4 A;  1RL5 A;  1ES7 B;  3BT2 U;  2UX2 A;  4QTI U;  2L5S A;  2BHI A;  2L03 A;  4LFT A;  3QB4 B;  3KFD E;  2BTX A;  1QKD A;  1CDS A;  3HH7 A;  1NOR A;  5EBX A;  1KBA A;  1W6B A;  4IYE A;  1CHV S;  1HC9 A;  1NYS A;  1KXI A;  2PJY C;  2CDX A;  1CCQ A;  1HC9 B;  3EBX A;  1TXA A;  1CVO A;  4OM4 A;  4UY2 C;  1KTZ B;  2JQP A;  1KBT A;  1FSS B;  2CTX A;  5DO6 A;  1QKE A;  5DZ5 A;  4EY8 B;  1CB9 A;  1LSI A;  3NEQ A;  1LXG A;  1ERA A;  2HLQ A;  2GOO B;  3VTS A;  2H64 B;  2LCR A;  3FEV A;  1ERG A;  1REW C;  1KL8 A;  2H62 C;  2QJB C;  4AEA A;  4HQP F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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