3HMSA

Crystal crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, orthorhombic crystal form
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
molecule keywords Hepatocyte growth factor
publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
source organism Homo sapiens
total genus 26
structure length 91
sequence length 91
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmsA00
2YIPA 5I25A 2YILA 4UAOA 4R1AA 2J8LA 5EODA 5CS3A 2QJ4A 4DURA 4Z0DA 5CP9A 4UV6A 5CT2A 3HN4A 3HMTA 5CS9A 4APLA 1I8NA 4Z09A 2Q8AA 1GMNA 2Y8RA 3MKPA 4A5TS 2LL3A 2Z8WA 2J8JA 5CS1A 2HGFA 4R1BA 5COEA 4Z0EA 4R1CA 3HMSA 4Z0FA 1W81A 5EOKA 5CT3A 1GMOA 3HMRA 1Z40A 5CSQA 1GP9A 2Q8BA 3ZLEA 4IUAA 1HKYA 3SRIA 3SP8A 5CT1A 1YXEA 2QJ2A 2YIOA 1NK1A 3ZWZA 2X2ZA 5CS5A 2K13X 4APMA 1BHTA 2F83A 2LL4M 4R19A 1W8KA 2Z8VA 3SRJA
chains in the Genus database with same CATH superfamily
2YIPA 5I25A 2YILA 4UAOA 4R1AA 2J8LA 4YIZA 5EODA 5CS3A 2QJ4A 4DURA 4Z0DA 5CP9A 4UV6A 5CT2A 3HN4A 3HMTA 5CS9A 4APLA 1I8NA 4Z09A 2Q8AA 4A5TS 1GMNA 2Y8RA 3MKPA 4YIVA 2LL3A 2Z8WA 2J8JA 5CS1A 2HGFA 4R1BA 5COEA 4Z0EA 4R1CA 3HMSA 4Z0FA 1W81A 5EOKA 5CT3A 2KL5A 1GMOA 3HMRA 1Z40A 5CSQA 1GP9A 2Q8BA 3ZLEA 4IUAA 1HKYA 3SRIA 3SP8A 5CT1A 1YXEA 2QJ2A 2YIOA 1NK1A 3ZWZA 2X2ZA 5CS5A 2K13X 4APMA 1BHTA 2F83A 2LL4M 4R19A 1W8KA 2Z8VA 3SRJA
chains in the Genus database with same CATH topology
2YIPA 5I25A 2YILA 4UAOA 4R1AA 2J8LA 4YIZA 5EODA 5CS3A 2QJ4A 4DURA 4Z0DA 5CP9A 4UV6A 5CT2A 3HN4A 3HMTA 5CS9A 4APLA 1I8NA 4Z09A 2Q8AA 4A5TS 1GMNA 2Y8RA 3MKPA 4YIVA 2LL3A 2Z8WA 2J8JA 5CS1A 2HGFA 4R1BA 5COEA 4Z0EA 4R1CA 3HMSA 4Z0FA 1W81A 5EOKA 5CT3A 2KL5A 1GMOA 3HMRA 1Z40A 5CSQA 1GP9A 2Q8BA 3ZLEA 4IUAA 1HKYA 3SRIA 3SP8A 5CT1A 1YXEA 2QJ2A 2YIOA 1NK1A 3ZWZA 2X2ZA 5CS5A 2K13X 4APMA 1BHTA 2F83A 2LL4M 4R19A 1W8KA 2Z8VA 3SRJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YIP A;  5I25 A;  2YIL A;  4UAO A;  4R1A A;  2J8L A;  5EOD A;  5CS3 A;  2QJ4 A;  4DUR A;  4Z0D A;  5CP9 A;  4UV6 A;  5CT2 A;  3HN4 A;  3HMT A;  5CS9 A;  4APL A;  1I8N A;  4Z09 A;  2Q8A A;  1GMN A;  2Y8R A;  3MKP A;  4A5T S;  2LL3 A;  2Z8W A;  2J8J A;  5CS1 A;  2HGF A;  4R1B A;  5COE A;  4Z0E A;  4R1C A;  3HMS A;  4Z0F A;  1W81 A;  5EOK A;  5CT3 A;  1GMO A;  3HMR A;  1Z40 A;  5CSQ A;  1GP9 A;  2Q8B A;  3ZLE A;  4IUA A;  1HKY A;  3SRI A;  3SP8 A;  5CT1 A;  1YXE A;  2QJ2 A;  2YIO A;  1NK1 A;  3ZWZ A;  2X2Z A;  5CS5 A;  2K13 X;  4APM A;  1BHT A;  2F83 A;  2LL4 M;  4R19 A;  1W8K A;  2Z8V A;  3SRJ A; 
#chains in the Genus database with same CATH topology
 2YIP A;  5I25 A;  2YIL A;  4UAO A;  4R1A A;  2J8L A;  4YIZ A;  5EOD A;  5CS3 A;  2QJ4 A;  4DUR A;  4Z0D A;  5CP9 A;  4UV6 A;  5CT2 A;  3HN4 A;  3HMT A;  5CS9 A;  4APL A;  1I8N A;  4Z09 A;  2Q8A A;  4A5T S;  1GMN A;  2Y8R A;  3MKP A;  4YIV A;  2LL3 A;  2Z8W A;  2J8J A;  5CS1 A;  2HGF A;  4R1B A;  5COE A;  4Z0E A;  4R1C A;  3HMS A;  4Z0F A;  1W81 A;  5EOK A;  5CT3 A;  2KL5 A;  1GMO A;  3HMR A;  1Z40 A;  5CSQ A;  1GP9 A;  2Q8B A;  3ZLE A;  4IUA A;  1HKY A;  3SRI A;  3SP8 A;  5CT1 A;  1YXE A;  2QJ2 A;  2YIO A;  1NK1 A;  3ZWZ A;  2X2Z A;  5CS5 A;  2K13 X;  4APM A;  1BHT A;  2F83 A;  2LL4 M;  4R19 A;  1W8K A;  2Z8V A;  3SRJ A; 
#chains in the Genus database with same CATH homology
 2YIP A;  5I25 A;  2YIL A;  4UAO A;  4R1A A;  2J8L A;  4YIZ A;  5EOD A;  5CS3 A;  2QJ4 A;  4DUR A;  4Z0D A;  5CP9 A;  4UV6 A;  5CT2 A;  3HN4 A;  3HMT A;  5CS9 A;  4APL A;  1I8N A;  4Z09 A;  2Q8A A;  4A5T S;  1GMN A;  2Y8R A;  3MKP A;  4YIV A;  2LL3 A;  2Z8W A;  2J8J A;  5CS1 A;  2HGF A;  4R1B A;  5COE A;  4Z0E A;  4R1C A;  3HMS A;  4Z0F A;  1W81 A;  5EOK A;  5CT3 A;  2KL5 A;  1GMO A;  3HMR A;  1Z40 A;  5CSQ A;  1GP9 A;  2Q8B A;  3ZLE A;  4IUA A;  1HKY A;  3SRI A;  3SP8 A;  5CT1 A;  1YXE A;  2QJ2 A;  2YIO A;  1NK1 A;  3ZWZ A;  2X2Z A;  5CS5 A;  2K13 X;  4APM A;  1BHT A;  2F83 A;  2LL4 M;  4R19 A;  1W8K A;  2Z8V A;  3SRJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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