3HMSA

Crystal crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, orthorhombic crystal form
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
molecule tags Hormone
source organism Homo sapiens
total genus 26
structure length 91
sequence length 91
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmsA00
5CT2A 3SRIA 1W81A 2F83A 5I25A 3HMSA 4R19A 5COEA 5CP9A 5EOKA 4Z0DA 1Z40A 3MKPA 1GMOA 4IUAA 2Q8AA 4Z09A 4R1BA 4DURA 3HMTA 2LL3A 4UV6A 5CT3A 5CT1A 3HMRA 4A5TS 2HGFA 2YILA 5CSQA 1I8NA 5EODA 2J8JA 2Q8BA 3ZWZA 5CS9A 1YXEA 2Z8WA 2YIPA 4Z0EA 2X2ZA 2QJ4A 3SP8A 2LL4M 1GMNA 2Y8RA 4R1AA 5CS5A 4UAOA 1W8KA 3SRJA 5CS3A 4APMA 2Z8VA 1GP9A 3HN4A 4R1CA 2K13X 3ZLEA 2YIOA 4Z0FA 4APLA 1BHTA 2J8LA 5CS1A 1HKYA 2QJ2A 1NK1A
chains in the Genus database with same CATH superfamily
5CT2A 3SRIA 1W81A 2F83A 5I25A 3HMSA 4R19A 5COEA 5CP9A 5EOKA 4Z0DA 1Z40A 3MKPA 1GMOA 4IUAA 2Q8AA 4Z09A 4R1BA 4DURA 3HMTA 2KL5A 2LL3A 4UV6A 5CT3A 5CT1A 3HMRA 4A5TS 2HGFA 2YILA 5CSQA 1I8NA 5EODA 2J8JA 2Q8BA 3ZWZA 5CS9A 1YXEA 4YIZA 2Z8WA 2YIPA 4Z0EA 2X2ZA 2QJ4A 3SP8A 2LL4M 1GMNA 2Y8RA 4R1AA 5CS5A 4UAOA 1W8KA 3SRJA 5CS3A 4APMA 2Z8VA 1GP9A 3HN4A 4R1CA 2K13X 3ZLEA 2YIOA 4YIVA 4Z0FA 4APLA 1BHTA 2J8LA 5CS1A 1HKYA 2QJ2A 1NK1A
chains in the Genus database with same CATH topology
5CT2A 3SRIA 1W81A 2F83A 5I25A 3HMSA 4R19A 5COEA 5CP9A 5EOKA 4Z0DA 1Z40A 3MKPA 1GMOA 4IUAA 2Q8AA 4Z09A 4R1BA 4DURA 3HMTA 2KL5A 2LL3A 4UV6A 5CT3A 5CT1A 3HMRA 4A5TS 2HGFA 2YILA 5CSQA 1I8NA 5EODA 2J8JA 2Q8BA 3ZWZA 5CS9A 1YXEA 4YIZA 2Z8WA 2YIPA 4Z0EA 2X2ZA 2QJ4A 3SP8A 2LL4M 1GMNA 2Y8RA 4R1AA 5CS5A 4UAOA 1W8KA 3SRJA 5CS3A 4APMA 2Z8VA 1GP9A 3HN4A 4R1CA 2K13X 3ZLEA 2YIOA 4YIVA 4Z0FA 4APLA 1BHTA 2J8LA 5CS1A 1HKYA 2QJ2A 1NK1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CT2 A;  3SRI A;  1W81 A;  2F83 A;  5I25 A;  3HMS A;  4R19 A;  5COE A;  5CP9 A;  5EOK A;  4Z0D A;  1Z40 A;  3MKP A;  1GMO A;  4IUA A;  2Q8A A;  4Z09 A;  4R1B A;  4DUR A;  3HMT A;  2LL3 A;  4UV6 A;  5CT3 A;  5CT1 A;  3HMR A;  4A5T S;  2HGF A;  2YIL A;  5CSQ A;  1I8N A;  5EOD A;  2J8J A;  2Q8B A;  3ZWZ A;  5CS9 A;  1YXE A;  2Z8W A;  2YIP A;  4Z0E A;  2X2Z A;  2QJ4 A;  3SP8 A;  2LL4 M;  1GMN A;  2Y8R A;  4R1A A;  5CS5 A;  4UAO A;  1W8K A;  3SRJ A;  5CS3 A;  4APM A;  2Z8V A;  1GP9 A;  3HN4 A;  4R1C A;  2K13 X;  3ZLE A;  2YIO A;  4Z0F A;  4APL A;  1BHT A;  2J8L A;  5CS1 A;  1HKY A;  2QJ2 A;  1NK1 A; 
#chains in the Genus database with same CATH topology
 5CT2 A;  3SRI A;  1W81 A;  2F83 A;  5I25 A;  3HMS A;  4R19 A;  5COE A;  5CP9 A;  5EOK A;  4Z0D A;  1Z40 A;  3MKP A;  1GMO A;  4IUA A;  2Q8A A;  4Z09 A;  4R1B A;  4DUR A;  3HMT A;  2KL5 A;  2LL3 A;  4UV6 A;  5CT3 A;  5CT1 A;  3HMR A;  4A5T S;  2HGF A;  2YIL A;  5CSQ A;  1I8N A;  5EOD A;  2J8J A;  2Q8B A;  3ZWZ A;  5CS9 A;  1YXE A;  4YIZ A;  2Z8W A;  2YIP A;  4Z0E A;  2X2Z A;  2QJ4 A;  3SP8 A;  2LL4 M;  1GMN A;  2Y8R A;  4R1A A;  5CS5 A;  4UAO A;  1W8K A;  3SRJ A;  5CS3 A;  4APM A;  2Z8V A;  1GP9 A;  3HN4 A;  4R1C A;  2K13 X;  3ZLE A;  2YIO A;  4YIV A;  4Z0F A;  4APL A;  1BHT A;  2J8L A;  5CS1 A;  1HKY A;  2QJ2 A;  1NK1 A; 
#chains in the Genus database with same CATH homology
 5CT2 A;  3SRI A;  1W81 A;  2F83 A;  5I25 A;  3HMS A;  4R19 A;  5COE A;  5CP9 A;  5EOK A;  4Z0D A;  1Z40 A;  3MKP A;  1GMO A;  4IUA A;  2Q8A A;  4Z09 A;  4R1B A;  4DUR A;  3HMT A;  2KL5 A;  2LL3 A;  4UV6 A;  5CT3 A;  5CT1 A;  3HMR A;  4A5T S;  2HGF A;  2YIL A;  5CSQ A;  1I8N A;  5EOD A;  2J8J A;  2Q8B A;  3ZWZ A;  5CS9 A;  1YXE A;  4YIZ A;  2Z8W A;  2YIP A;  4Z0E A;  2X2Z A;  2QJ4 A;  3SP8 A;  2LL4 M;  1GMN A;  2Y8R A;  4R1A A;  5CS5 A;  4UAO A;  1W8K A;  3SRJ A;  5CS3 A;  4APM A;  2Z8V A;  1GP9 A;  3HN4 A;  4R1C A;  2K13 X;  3ZLE A;  2YIO A;  4YIV A;  4Z0F A;  4APL A;  1BHT A;  2J8L A;  5CS1 A;  1HKY A;  2QJ2 A;  1NK1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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