3HMTA

Crystal structure of the n-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, trigonal crystal form
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
91
structure length
91
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
molecule keywords Hepatocyte growth factor
publication title Structural basis for agonism and antagonism of hepatocyte growth factor.
pubmed doi rcsb
source organism Homo sapiens
total genus 25
structure length 91
sequence length 91
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-05-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3hmtA00
2LL3A 5CS5A 1YXEA 2YIPA 3ZLEA 2J8JA 4IUAA 2Z8WA 4Z0EA 3HMRA 4APLA 3MKPA 5CP9A 2YILA 4A5TS 4UV6A 1BHTA 3SRIA 2Z8VA 5CS9A 4R1AA 5EODA 1I8NA 2YIOA 5CS3A 4Z09A 2Q8BA 4R1BA 2Q8AA 4UAOA 1GP9A 2F83A 5CT2A 3HMSA 2QJ2A 1W8KA 5I25A 3SRJA 1W81A 4R19A 4Z0DA 3ZWZA 2K13X 3HN4A 1GMNA 1Z40A 3HMTA 5CT3A 2X2ZA 3SP8A 4Z0FA 5COEA 4APMA 2LL4M 1GMOA 1NK1A 4R1CA 1HKYA 5EOKA 2QJ4A 2HGFA 2J8LA 2Y8RA 5CT1A 5CS1A 4DURA 5CSQA
chains in the Genus database with same CATH superfamily
2LL3A 5CS5A 1YXEA 2YIPA 3ZLEA 2J8JA 4IUAA 2Z8WA 4Z0EA 3HMRA 4APLA 3MKPA 5CP9A 2YILA 4A5TS 4UV6A 1BHTA 3SRIA 2Z8VA 5CS9A 4R1AA 5EODA 1I8NA 2YIOA 5CS3A 4Z09A 2Q8BA 4R1BA 2Q8AA 4UAOA 1GP9A 2F83A 5CT2A 3HMSA 2QJ2A 1W8KA 5I25A 3SRJA 1W81A 4R19A 4Z0DA 3ZWZA 2K13X 3HN4A 1GMNA 1Z40A 3HMTA 5CT3A 2X2ZA 3SP8A 4YIZA 4Z0FA 5COEA 4APMA 2LL4M 1GMOA 1NK1A 4R1CA 1HKYA 5EOKA 2QJ4A 2HGFA 2J8LA 2Y8RA 4YIVA 2KL5A 5CS1A 5CT1A 4DURA 5CSQA
chains in the Genus database with same CATH topology
2LL3A 5CS5A 1YXEA 2YIPA 3ZLEA 2J8JA 4IUAA 2Z8WA 4Z0EA 3HMRA 4APLA 3MKPA 5CP9A 2YILA 4A5TS 4UV6A 1BHTA 3SRIA 2Z8VA 5CS9A 4R1AA 5EODA 1I8NA 2YIOA 5CS3A 4Z09A 2Q8BA 4R1BA 2Q8AA 4UAOA 1GP9A 2F83A 5CT2A 3HMSA 2QJ2A 1W8KA 5I25A 3SRJA 1W81A 4R19A 4Z0DA 3ZWZA 2K13X 3HN4A 1GMNA 1Z40A 3HMTA 5CT3A 2X2ZA 3SP8A 4YIZA 4Z0FA 5COEA 4APMA 2LL4M 1GMOA 1NK1A 4R1CA 1HKYA 5EOKA 2QJ4A 2HGFA 2J8LA 2Y8RA 4YIVA 2KL5A 5CS1A 5CT1A 4DURA 5CSQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2LL3 A;  5CS5 A;  1YXE A;  2YIP A;  3ZLE A;  2J8J A;  4IUA A;  2Z8W A;  4Z0E A;  3HMR A;  4APL A;  3MKP A;  5CP9 A;  2YIL A;  4A5T S;  4UV6 A;  1BHT A;  3SRI A;  2Z8V A;  5CS9 A;  4R1A A;  5EOD A;  1I8N A;  2YIO A;  5CS3 A;  4Z09 A;  2Q8B A;  4R1B A;  2Q8A A;  4UAO A;  1GP9 A;  2F83 A;  5CT2 A;  3HMS A;  2QJ2 A;  1W8K A;  5I25 A;  3SRJ A;  1W81 A;  4R19 A;  4Z0D A;  3ZWZ A;  2K13 X;  3HN4 A;  1GMN A;  1Z40 A;  3HMT A;  5CT3 A;  2X2Z A;  3SP8 A;  4Z0F A;  5COE A;  4APM A;  2LL4 M;  1GMO A;  1NK1 A;  4R1C A;  1HKY A;  5EOK A;  2QJ4 A;  2HGF A;  2J8L A;  2Y8R A;  5CT1 A;  5CS1 A;  4DUR A;  5CSQ A; 
#chains in the Genus database with same CATH topology
 2LL3 A;  5CS5 A;  1YXE A;  2YIP A;  3ZLE A;  2J8J A;  4IUA A;  2Z8W A;  4Z0E A;  3HMR A;  4APL A;  3MKP A;  5CP9 A;  2YIL A;  4A5T S;  4UV6 A;  1BHT A;  3SRI A;  2Z8V A;  5CS9 A;  4R1A A;  5EOD A;  1I8N A;  2YIO A;  5CS3 A;  4Z09 A;  2Q8B A;  4R1B A;  2Q8A A;  4UAO A;  1GP9 A;  2F83 A;  5CT2 A;  3HMS A;  2QJ2 A;  1W8K A;  5I25 A;  3SRJ A;  1W81 A;  4R19 A;  4Z0D A;  3ZWZ A;  2K13 X;  3HN4 A;  1GMN A;  1Z40 A;  3HMT A;  5CT3 A;  2X2Z A;  3SP8 A;  4YIZ A;  4Z0F A;  5COE A;  4APM A;  2LL4 M;  1GMO A;  1NK1 A;  4R1C A;  1HKY A;  5EOK A;  2QJ4 A;  2HGF A;  2J8L A;  2Y8R A;  4YIV A;  2KL5 A;  5CS1 A;  5CT1 A;  4DUR A;  5CSQ A; 
#chains in the Genus database with same CATH homology
 2LL3 A;  5CS5 A;  1YXE A;  2YIP A;  3ZLE A;  2J8J A;  4IUA A;  2Z8W A;  4Z0E A;  3HMR A;  4APL A;  3MKP A;  5CP9 A;  2YIL A;  4A5T S;  4UV6 A;  1BHT A;  3SRI A;  2Z8V A;  5CS9 A;  4R1A A;  5EOD A;  1I8N A;  2YIO A;  5CS3 A;  4Z09 A;  2Q8B A;  4R1B A;  2Q8A A;  4UAO A;  1GP9 A;  2F83 A;  5CT2 A;  3HMS A;  2QJ2 A;  1W8K A;  5I25 A;  3SRJ A;  1W81 A;  4R19 A;  4Z0D A;  3ZWZ A;  2K13 X;  3HN4 A;  1GMN A;  1Z40 A;  3HMT A;  5CT3 A;  2X2Z A;  3SP8 A;  4YIZ A;  4Z0F A;  5COE A;  4APM A;  2LL4 M;  1GMO A;  1NK1 A;  4R1C A;  1HKY A;  5EOK A;  2QJ4 A;  2HGF A;  2J8L A;  2Y8R A;  4YIV A;  2KL5 A;  5CS1 A;  5CT1 A;  4DUR A;  5CSQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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