3HY7A

Crystal structure of the catalytic domain of adamts-5 in complex with marimastat
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
217
structure length
217
Chain Sequence
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
publication title Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 73
structure length 217
sequence length 217
chains with identical sequence B
ec nomenclature ec 3.4.24.-:
pdb deposition date 2009-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3hy7A00
3F16A 3LUMA 1R54A 1FLSA 4CTHA 2MZEA 5CXAA 1D8MA 3Q2GA 3N2UA 4I35A 3F19A 1KUGA 2JT5A 3OHOA 3KMEA 1UMTA 1RMZA 4R3VA 5D2BA 1IABA 3DNGA 1DMTA 3HY9A 1CQRA 1XURA 2OI0A 4GR0A 4H1QA 5I2ZA 1YQYA 4FVLA 5CZMA 1SLNA 4H82A 1SLMA 3B8ZA 3LQBA 1EB6A 1KUKA 3F17A 3MA2A 4XBHA 1H71P 3CKIA 1EUBA 1G49A 3LILA 5I43A 4G0DA 2JT6A 2TCLA 1IAGA 2E3XA 2W13A 1G05A 3TVCA 2W12A 2XS3A 3O64A 2OVXA 2KRJA 4XCTA 2L0RA 4ON1A 2EROA 1HFCA 1QICA 4A3WA 1C8TA 1BIWA 3B92A 1GO7P 1OS9A 1ZXVA 1IADA 2OXZA 3RTTA 3LK8A 3LGPA 1JAOA 2PJTA 4AUOA 1CXVA 3LMCA 1BZSA 4IJOA 1KBCA 1R1JA 1MMRA 2DDFA 4QKZA 1GE5A 4Q1LA 1JAQA 3I7GA 3U1RA 4H84A 1SATA 1SU3A 2HU6A 3AIGA 4A7BA 966CA 1JK3A 4JQGA 3P24A 4JIJA 3LJGA 1D5JA 1CK7A 1ATLA 1GO8P 1KAPP 1QJIA 4H49A 1A86A 3V96B 2ERQA 1Z3JA 2OW1A 4G9LA 4GUYA 5B5OA 3LEAA 3F15A 1WNIA 1BM6A 3LIKA 3NX7A 1MNCA 4HMAA 1IAEA 1MMPA 1RM8A 4PKUA 3ZUKA 1HFSA 1XFYA 1B3DA 2JSDA 3O2XA 1BUVM 1IACA 1CGLA 2OZRA 2J83A 4H3XA 3HDAP 3Q2HA 2X3AA 1K7QA 3F1AA 1XUDA 1QUAA 1AF0A 1IAAA 4PKQA 2YB9A 1FM1A 5L79A 4XM7A 1ZTQA 2CLTA 4XM8A 3USNA 3TS4A 3WV3A 3SHIA 5D1UA 5JMYA 1UTTA 1G9KA 1ZVXA 1ZP5A 1D8FA 2W0DA 1JH1A 2X7MA 3TT4A 2SRTA 2OW0A 3KWVC 1HV5A 3EDGA 1C3IA 1QJJA 3L0TA 5CUHA 3BA0A 4WKEA 1PWUA 3K7LA 2DW1A 5D3CA 4JA1A 4ZR5A 3RTSA 2ERPA 1C7KA 4DPEA 4FXQA 2A8HA 4L63A 1KUFA 4PKVA 5B5PA 5I4OA 4H30A 5LABA 3G5CA 1R1IA 2O36A 1OM8A 2X3BA 3EHYA 1BQOA 3EDIA 1PWPA 1R1HA 1G4KA 2OW2A 2AIGP 1JIWP 2DW2A 2K9CA 3DL1A 4GR8A 3P1VA 3KMCA 4IN9A 1XFZA 2CKIA 4DV8A 3GBOA 3LKAA 4DD8A 1JJ9A 3HBVP 1OMJA 3AYUA 1OS2A 2MLRA 4GWNA 2W14A 1PWWA 4WZVA 3KECA 1JANA 2JIHA 1O0QA 3AYKA 1ND1A 3HYGA 3EHXA 3TSKA 4H2EA 5BOYA 3L0VA 2OW9A 2DDYA 3E8RA 2DW0A 1BSWA 3LJTA 2I47A 3LIRA 3ELMA 4XM6A 1K7GA 2JNPA 3WV1A 3WV2A 1Y8JA 3HB2P 4AIGA 1BUDA 2MLSA 1S4BP 1MMBA 3F18A 3EWJA 3DPFA 1GE7A 2MZIA 3K7NA 3KHIA 1HTDA 1JAPA 3EDHA 4WKIA 3DPEA 3VI1A 4JP4A 1XFWA 4PKTA 2XS4A 1MMQA 1PWQA 3LE9A 1QIAA 1BKCI 3VTGA 1KUIA 2OY4A 1XUCA 4L19A 4DF9A 1JKYA 3G42A 1ASTA 2OVZA 4ILWD 5L7FA 4PKWA 2O3EA 1CGFA 1Y0VA 2QPJA 1FBLA 1J7NA 4FXYP 2N8RA 2MZHA 4FU4A 3KEJA 5D1SA 3HY7A 4PKRA 1OO9A 1XFXA 1B8YA 1K7IA 2AYKA 2WO8A 4WF6A 1JIZA 830CA 1A85A 2W15A 4EFSA 2X3CA 5BPAA 1O0TA 1Q3AA 1HOVA 1XFUA 4HX3A 3KRYA 2OXWA 2OXUA 1BKCA 1I1IP 1AYKA 3DSLA 3ZXHA 1HY7A 1L6JA 1G12A 2V4BA 4JPAA 3ZVSA 1PWVA 4GQLA 1DTHA 4H76A 3LJZA 1I76A 3I7IA 2RJPA 1GKCA 3LQ0A 1ZXCA 5D7WA 2D1OA 1SRPA 4WK7A 1BQQM 1UEAA 3UVCA 4AYKA 5H8XA 1SMPA 2D1NA 3HBUP 3HDBA 4L6TA 2E2DA 1ROSA 5I12A 1YCMA 456CA 1CGEA 2J0TA 2Y6CA 1UMSA 3KEKA 1OM7A 4AXQA 2Z2DA 4GWMA 1CIZA 3EDZA 4IUWA 4GF1A 4PKSA 1OM6A 1R55A 2WO9A 4J4MA 2OY2A 2WOAA 2YIGA 1D7XA 5I3MA 1I73A 1EAKA 1GXDA 1XFVA 2K2GA 2RJQA 1UTZA 5D1TA 1AKLA 1YOUA 2FV5A 1USNA 4I03A 1ZS0A 2FV9A 4GR3A 1CAQA 2Y6DA 3B2ZA 3N2VA 1GE6A 3DWBA 3LUNA 1BKCE 1Y93A 5BOTA 1GKDA 1QIBA 2POJA 1KUHA 1YP1A 3OHLA 2USNA 5I0LA
chains in the Genus database with same CATH superfamily
3F16A 3LUMA 1R54A 1FLSA 4CTHA 2MZEA 5CXAA 1D8MA 3Q2GA 3N2UA 4I35A 3F19A 1KUGA 2JT5A 3OHOA 3KMEA 1UMTA 1RMZA 4R3VA 5D2BA 1IABA 3DNGA 1DMTA 3HY9A 1CQRA 1XURA 2OI0A 4GR0A 4H1QA 5I2ZA 1YQYA 4FVLA 5CZMA 1SLNA 4H82A 1SLMA 3B8ZA 3LQBA 1EB6A 1KUKA 3F17A 3MA2A 4XBHA 1H71P 3CKIA 1EUBA 1G49A 3LILA 5I43A 4G0DA 2JT6A 2TCLA 1IAGA 2E3XA 2W13A 1G05A 3TVCA 2W12A 2XS3A 3O64A 2OVXA 2KRJA 4XCTA 2L0RA 4ON1A 2EROA 1HFCA 1QICA 4A3WA 1C8TA 1BIWA 3B92A 1GO7P 1OS9A 1ZXVA 1IADA 2OXZA 3RTTA 3LK8A 3LGPA 1JAOA 2PJTA 4AUOA 1CXVA 3LMCA 1BZSA 4IJOA 1KBCA 1R1JA 1MMRA 2DDFA 4QKZA 1GE5A 4Q1LA 1JAQA 3DTIA 3I7GA 3U1RA 4H84A 1SATA 1SU3A 2HU6A 3AIGA 3DTEA 4A7BA 966CA 1TVIA 1JK3A 4JQGA 3P24A 4JIJA 3LJGA 1D5JA 1CK7A 1ATLA 1GO8P 1KAPP 1QJIA 4H49A 1A86A 3V96B 2ERQA 1Z3JA 2OW1A 4G9LA 4GUYA 5B5OA 3LEAA 3F15A 1WNIA 1BM6A 3LIKA 3NX7A 1MNCA 4HMAA 1IAEA 1MMPA 1RM8A 4PKUA 3ZUKA 1HFSA 1XFYA 1B3DA 2JSDA 3O2XA 1BUVM 1IACA 1CGLA 2OZRA 2J83A 4H3XA 3HDAP 3Q2HA 2X3AA 1K7QA 3F1AA 1XUDA 1QUAA 1AF0A 1IAAA 4PKQA 2YB9A 1FM1A 5L79A 4XM7A 1ZTQA 2CLTA 4XM8A 3USNA 3TS4A 3WV3A 3SHIA 2YUFA 5D1UA 5JMYA 1UTTA 1G9KA 1ZVXA 1ZP5A 1D8FA 2W0DA 1JH1A 2X7MA 3TT4A 2SRTA 2OW0A 3KWVC 1HV5A 3EDGA 1C3IA 1QJJA 3L0TA 5CUHA 3BA0A 4WKEA 1PWUA 3K7LA 2DW1A 5D3CA 4JA1A 4ZR5A 3RTSA 2ERPA 1C7KA 4DPEA 4FXQA 2A8HA 4L63A 1KUFA 4PKVA 5B5PA 5I4OA 4H30A 5LABA 3G5CA 1R1IA 2O36A 1OM8A 2X3BA 3EHYA 1BQOA 3EDIA 1PWPA 1R1HA 1G4KA 2OW2A 2AIGP 1JIWP 2DW2A 2K9CA 3DL1A 4GR8A 3P1VA 3KMCA 4IN9A 1XFZA 2CKIA 4DV8A 3GBOA 3LKAA 4DD8A 1JJ9A 3HBVP 1OMJA 3AYUA 1OS2A 2MLRA 4GWNA 2W14A 1PWWA 4WZVA 3KECA 1JANA 2JIHA 1O0QA 3AYKA 1ND1A 3HYGA 3EHXA 3TSKA 4H2EA 5BOYA 3L0VA 2OW9A 2DDYA 3E8RA 2DW0A 1BSWA 3LJTA 2I47A 3LIRA 3ELMA 4XM6A 1K7GA 2JNPA 3WV1A 3WV2A 1Y8JA 3HB2P 4AIGA 1BUDA 2MLSA 1S4BP 1MMBA 3F18A 3EWJA 3DPFA 1GE7A 2MZIA 3DTKA 3K7NA 3KHIA 1HTDA 1JAPA 3EDHA 4WKIA 3DPEA 3VI1A 4JP4A 1XFWA 4PKTA 2XS4A 1XM5A 1MMQA 1PWQA 3LE9A 1QIAA 1BKCI 3VTGA 1KUIA 1OZ9A 2OY4A 1XUCA 1XAXA 4L19A 4DF9A 1JKYA 3G42A 1ASTA 2OVZA 4ILWD 5L7FA 4PKWA 2O3EA 1CGFA 1Y0VA 2QPJA 1FBLA 1J7NA 4FXYP 2N8RA 2MZHA 4FU4A 3KEJA 5D1SA 3HY7A 4PKRA 1OO9A 1XFXA 1B8YA 1K7IA 2AYKA 2WO8A 4WF6A 1JIZA 830CA 1A85A 2W15A 4EFSA 2X3CA 5BPAA 1O0TA 1Q3AA 1HOVA 1XFUA 4HX3A 3KRYA 2OXWA 2OXUA 1BKCA 1I1IP 1AYKA 3DSLA 3ZXHA 1HY7A 1L6JA 1G12A 2V4BA 4JPAA 3ZVSA 1PWVA 4GQLA 1DTHA 4H76A 3LJZA 1I76A 3I7IA 2RJPA 1GKCA 3LQ0A 1ZXCA 5D7WA 2D1OA 1SRPA 4WK7A 1BQQM 1UEAA 3UVCA 4AYKA 5H8XA 1SMPA 4L7AA 2D1NA 3HBUP 3HDBA 4L6TA 2E2DA 1ROSA 5I12A 1YCMA 456CA 1CGEA 2J0TA 2Y6CA 1UMSA 3KEKA 1OM7A 4AXQA 2Z2DA 4GWMA 1CIZA 3EDZA 4IUWA 4GF1A 4PKSA 1OM6A 1R55A 2WO9A 4J4MA 2OY2A 2WOAA 2YIGA 1D7XA 5I3MA 1I73A 1EAKA 1GXDA 1XFVA 2K2GA 2RJQA 1UTZA 5D1TA 1AKLA 1YOUA 2FV5A 1USNA 4I03A 1ZS0A 2FV9A 4GR3A 1CAQA 2Y6DA 3B2ZA 3N2VA 1GE6A 3DWBA 3LUNA 1BKCE 1Y93A 5BOTA 1GKDA 1QIBA 2POJA 1KUHA 1YP1A 3OHLA 2USNA 5I0LA
chains in the Genus database with same CATH topology
3F16A 3LUMA 1R54A 1FLSA 4CTHA 2MZEA 5CXAA 1D8MA 3Q2GA 3N2UA 4I35A 3F19A 1KUGA 2JT5A 3OHOA 3KMEA 1UMTA 1RMZA 4R3VA 5D2BA 1IABA 3DNGA 1DMTA 3HY9A 1CQRA 1XURA 2OI0A 4GR0A 4H1QA 5I2ZA 1YQYA 4FVLA 5CZMA 1SLNA 4H82A 1SLMA 3B8ZA 3LQBA 1EB6A 1KUKA 3F17A 3MA2A 4XBHA 1H71P 3CKIA 1EUBA 1G49A 3LILA 5I43A 4G0DA 2JT6A 2TCLA 1IAGA 2E3XA 2W13A 1G05A 3TVCA 2W12A 2XS3A 3O64A 2OVXA 2KRJA 4XCTA 2L0RA 4ON1A 2EROA 1HFCA 1QICA 4A3WA 1C8TA 1BIWA 3B92A 1GO7P 1OS9A 1ZXVA 1IADA 2OXZA 3RTTA 3LK8A 3LGPA 1JAOA 2PJTA 4AUOA 1CXVA 3LMCA 1BZSA 4IJOA 1KBCA 1R1JA 1MMRA 2DDFA 4QKZA 1GE5A 4Q1LA 1JAQA 3DTIA 3I7GA 3U1RA 4H84A 1SATA 1SU3A 2HU6A 3AIGA 3DTEA 4A7BA 966CA 1JK3A 4JQGA 3P24A 4JIJA 3LJGA 1D5JA 1CK7A 1ATLA 1GO8P 1KAPP 1QJIA 4H49A 1A86A 3V96B 2ERQA 1Z3JA 2OW1A 4G9LA 4GUYA 5B5OA 3LEAA 3F15A 1WNIA 1BM6A 3LIKA 3NX7A 1MNCA 4HMAA 1IAEA 1MMPA 1RM8A 4PKUA 3ZUKA 1HFSA 1XFYA 1B3DA 2JSDA 3O2XA 1BUVM 1IACA 1CGLA 2OZRA 2J83A 4H3XA 3HDAP 3Q2HA 2X3AA 1K7QA 3F1AA 1XUDA 1QUAA 1AF0A 1IAAA 4PKQA 2YB9A 1FM1A 5L79A 4XM7A 1ZTQA 2CLTA 4XM8A 3USNA 3TS4A 3WV3A 3SHIA 2YUFA 5D1UA 5JMYA 1UTTA 1G9KA 1ZVXA 1ZP5A 1D8FA 2W0DA 1JH1A 2X7MA 3TT4A 2SRTA 2OW0A 3KWVC 1HV5A 3EDGA 1C3IA 1QJJA 3L0TA 5CUHA 3BA0A 4WKEA 1PWUA 3K7LA 2DW1A 5D3CA 4JA1A 4ZR5A 3RTSA 2ERPA 1C7KA 4DPEA 4FXQA 2A8HA 4L63A 1KUFA 4PKVA 5B5PA 5I4OA 4H30A 5LABA 3G5CA 1R1IA 2O36A 1OM8A 2X3BA 3EHYA 1BQOA 3EDIA 1PWPA 1R1HA 1G4KA 2OW2A 2AIGP 1JIWP 2DW2A 2K9CA 3DL1A 4GR8A 3P1VA 3KMCA 4IN9A 1XFZA 2CKIA 4DV8A 3GBOA 3LKAA 4DD8A 1JJ9A 3HBVP 1OMJA 3AYUA 1OS2A 2MLRA 4GWNA 2W14A 1PWWA 4WZVA 3KECA 1JANA 2JIHA 1O0QA 3AYKA 1ND1A 3HYGA 3EHXA 3TSKA 4H2EA 5BOYA 3L0VA 2OW9A 2DDYA 3E8RA 2DW0A 1BSWA 3LJTA 2I47A 3LIRA 3ELMA 4XM6A 1K7GA 2JNPA 3WV1A 3WV2A 1Y8JA 3HB2P 4AIGA 1BUDA 2MLSA 1S4BP 1MMBA 3F18A 3EWJA 3DPFA 1GE7A 2MZIA 3DTKA 3K7NA 3KHIA 1HTDA 1JAPA 3EDHA 4WKIA 3DPEA 3VI1A 4JP4A 1XFWA 4PKTA 2XS4A 1MMQA 1PWQA 3LE9A 1QIAA 1BKCI 3VTGA 1KUIA 2OY4A 1XUCA 4L19A 4DF9A 1JKYA 3G42A 1ASTA 2OVZA 4ILWD 5L7FA 4PKWA 2O3EA 1CGFA 1Y0VA 2QPJA 1FBLA 1J7NA 4FXYP 2N8RA 2MZHA 4FU4A 3KEJA 5D1SA 3HY7A 4PKRA 1OO9A 1XFXA 1B8YA 1K7IA 2AYKA 2WO8A 4WF6A 1JIZA 830CA 1A85A 2W15A 4EFSA 2X3CA 5BPAA 1O0TA 1Q3AA 1HOVA 1XFUA 4HX3A 3KRYA 2OXWA 2OXUA 1BKCA 1I1IP 1AYKA 3DSLA 3ZXHA 1HY7A 1L6JA 1G12A 2V4BA 4JPAA 3ZVSA 1PWVA 4GQLA 1DTHA 4H76A 3LJZA 1I76A 3I7IA 2RJPA 1GKCA 3LQ0A 1ZXCA 5D7WA 2D1OA 1SRPA 4WK7A 1BQQM 1UEAA 3UVCA 4AYKA 5H8XA 1SMPA 4L7AA 2D1NA 3HBUP 3HDBA 4L6TA 2E2DA 1ROSA 5I12A 1YCMA 456CA 1CGEA 2J0TA 2Y6CA 1UMSA 3KEKA 1OM7A 4AXQA 2Z2DA 4GWMA 1CIZA 3EDZA 4IUWA 4GF1A 4PKSA 1OM6A 1R55A 2WO9A 4J4MA 2OY2A 2WOAA 2YIGA 1D7XA 5I3MA 1I73A 1EAKA 1GXDA 1XFVA 2K2GA 2RJQA 1UTZA 5D1TA 1AKLA 1YOUA 2FV5A 1USNA 4I03A 1ZS0A 2FV9A 4GR3A 1CAQA 2Y6DA 3B2ZA 3N2VA 1GE6A 3DWBA 3LUNA 1BKCE 1Y93A 5BOTA 1GKDA 1QIBA 2POJA 1KUHA 1YP1A 3OHLA 2USNA 5I0LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3F16 A;  3LUM A;  1R54 A;  1FLS A;  4CTH A;  2MZE A;  5CXA A;  1D8M A;  3Q2G A;  3N2U A;  4I35 A;  3F19 A;  1KUG A;  2JT5 A;  3OHO A;  3KME A;  1UMT A;  1RMZ A;  4R3V A;  5D2B A;  1IAB A;  3DNG A;  1DMT A;  3HY9 A;  1CQR A;  1XUR A;  2OI0 A;  4GR0 A;  4H1Q A;  5I2Z A;  1YQY A;  4FVL A;  5CZM A;  1SLN A;  4H82 A;  1SLM A;  3B8Z A;  3LQB A;  1EB6 A;  1KUK A;  3F17 A;  3MA2 A;  4XBH A;  1H71 P;  3CKI A;  1EUB A;  1G49 A;  3LIL A;  5I43 A;  4G0D A;  2JT6 A;  2TCL A;  1IAG A;  2E3X A;  2W13 A;  1G05 A;  3TVC A;  2W12 A;  2XS3 A;  3O64 A;  2OVX A;  2KRJ A;  4XCT A;  2L0R A;  4ON1 A;  2ERO A;  1HFC A;  1QIC A;  4A3W A;  1C8T A;  1BIW A;  3B92 A;  1GO7 P;  1OS9 A;  1ZXV A;  1IAD A;  2OXZ A;  3RTT A;  3LK8 A;  3LGP A;  1JAO A;  2PJT A;  4AUO A;  1CXV A;  3LMC A;  1BZS A;  4IJO A;  1KBC A;  1R1J A;  1MMR A;  2DDF A;  4QKZ A;  1GE5 A;  4Q1L A;  1JAQ A;  3I7G A;  3U1R A;  4H84 A;  1SAT A;  1SU3 A;  2HU6 A;  3AIG A;  4A7B A;  966C A;  1JK3 A;  4JQG A;  3P24 A;  4JIJ A;  3LJG A;  1D5J A;  1CK7 A;  1ATL A;  1GO8 P;  1KAP P;  1QJI A;  4H49 A;  1A86 A;  3V96 B;  2ERQ A;  1Z3J A;  2OW1 A;  4G9L A;  4GUY A;  5B5O A;  3LEA A;  3F15 A;  1WNI A;  1BM6 A;  3LIK A;  3NX7 A;  1MNC A;  4HMA A;  1IAE A;  1MMP A;  1RM8 A;  4PKU A;  3ZUK A;  1HFS A;  1XFY A;  1B3D A;  2JSD A;  3O2X A;  1BUV M;  1IAC A;  1CGL A;  2OZR A;  2J83 A;  4H3X A;  3HDA P;  3Q2H A;  2X3A A;  1K7Q A;  3F1A A;  1XUD A;  1QUA A;  1AF0 A;  1IAA A;  4PKQ A;  2YB9 A;  1FM1 A;  5L79 A;  4XM7 A;  1ZTQ A;  2CLT A;  4XM8 A;  3USN A;  3TS4 A;  3WV3 A;  3SHI A;  5D1U A;  5JMY A;  1UTT A;  1G9K A;  1ZVX A;  1ZP5 A;  1D8F A;  2W0D A;  1JH1 A;  2X7M A;  3TT4 A;  2SRT A;  2OW0 A;  3KWV C;  1HV5 A;  3EDG A;  1C3I A;  1QJJ A;  3L0T A;  5CUH A;  3BA0 A;  4WKE A;  1PWU A;  3K7L A;  2DW1 A;  5D3C A;  4JA1 A;  4ZR5 A;  3RTS A;  2ERP A;  1C7K A;  4DPE A;  4FXQ A;  2A8H A;  4L63 A;  1KUF A;  4PKV A;  5B5P A;  5I4O A;  4H30 A;  5LAB A;  3G5C A;  1R1I A;  2O36 A;  1OM8 A;  2X3B A;  3EHY A;  1BQO A;  3EDI A;  1PWP A;  1R1H A;  1G4K A;  2OW2 A;  2AIG P;  1JIW P;  2DW2 A;  2K9C A;  3DL1 A;  4GR8 A;  3P1V A;  3KMC A;  4IN9 A;  1XFZ A;  2CKI A;  4DV8 A;  3GBO A;  3LKA A;  4DD8 A;  1JJ9 A;  3HBV P;  1OMJ A;  3AYU A;  1OS2 A;  2MLR A;  4GWN A;  2W14 A;  1PWW A;  4WZV A;  3KEC A;  1JAN A;  2JIH A;  1O0Q A;  3AYK A;  1ND1 A;  3HYG A;  3EHX A;  3TSK A;  4H2E A;  5BOY A;  3L0V A;  2OW9 A;  2DDY A;  3E8R A;  2DW0 A;  1BSW A;  3LJT A;  2I47 A;  3LIR A;  3ELM A;  4XM6 A;  1K7G A;  2JNP A;  3WV1 A;  3WV2 A;  1Y8J A;  3HB2 P;  4AIG A;  1BUD A;  2MLS A;  1S4B P;  1MMB A;  3F18 A;  3EWJ A;  3DPF A;  1GE7 A;  2MZI A;  3K7N A;  3KHI A;  1HTD A;  1JAP A;  3EDH A;  4WKI A;  3DPE A;  3VI1 A;  4JP4 A;  1XFW A;  4PKT A;  2XS4 A;  1MMQ A;  1PWQ A;  3LE9 A;  1QIA A;  1BKC I;  3VTG A;  1KUI A;  2OY4 A;  1XUC A;  4L19 A;  4DF9 A;  1JKY A;  3G42 A;  1AST A;  2OVZ A;  4ILW D;  5L7F A;  4PKW A;  2O3E A;  1CGF A;  1Y0V A;  2QPJ A;  1FBL A;  1J7N A;  4FXY P;  2N8R A;  2MZH A;  4FU4 A;  3KEJ A;  5D1S A;  3HY7 A;  4PKR A;  1OO9 A;  1XFX A;  1B8Y A;  1K7I A;  2AYK A;  2WO8 A;  4WF6 A;  1JIZ A;  830C A;  1A85 A;  2W15 A;  4EFS A;  2X3C A;  5BPA A;  1O0T A;  1Q3A A;  1HOV A;  1XFU A;  4HX3 A;  3KRY A;  2OXW A;  2OXU A;  1BKC A;  1I1I P;  1AYK A;  3DSL A;  3ZXH A;  1HY7 A;  1L6J A;  1G12 A;  2V4B A;  4JPA A;  3ZVS A;  1PWV A;  4GQL A;  1DTH A;  4H76 A;  3LJZ A;  1I76 A;  3I7I A;  2RJP A;  1GKC A;  3LQ0 A;  1ZXC A;  5D7W A;  2D1O A;  1SRP A;  4WK7 A;  1BQQ M;  1UEA A;  3UVC A;  4AYK A;  5H8X A;  1SMP A;  2D1N A;  3HBU P;  3HDB A;  4L6T A;  2E2D A;  1ROS A;  5I12 A;  1YCM A;  456C A;  1CGE A;  2J0T A;  2Y6C A;  1UMS A;  3KEK A;  1OM7 A;  4AXQ A;  2Z2D A;  4GWM A;  1CIZ A;  3EDZ A;  4IUW A;  4GF1 A;  4PKS A;  1OM6 A;  1R55 A;  2WO9 A;  4J4M A;  2OY2 A;  2WOA A;  2YIG A;  1D7X A;  5I3M A;  1I73 A;  1EAK A;  1GXD A;  1XFV A;  2K2G A;  2RJQ A;  1UTZ A;  5D1T A;  1AKL A;  1YOU A;  2FV5 A;  1USN A;  4I03 A;  1ZS0 A;  2FV9 A;  4GR3 A;  1CAQ A;  2Y6D A;  3B2Z A;  3N2V A;  1GE6 A;  3DWB A;  3LUN A;  1BKC E;  1Y93 A;  5BOT A;  1GKD A;  1QIB A;  2POJ A;  1KUH A;  1YP1 A;  3OHL A;  2USN A;  5I0L A; 
#chains in the Genus database with same CATH topology
 3F16 A;  3LUM A;  1R54 A;  1FLS A;  4CTH A;  2MZE A;  5CXA A;  1D8M A;  3Q2G A;  3N2U A;  4I35 A;  3F19 A;  1KUG A;  2JT5 A;  3OHO A;  3KME A;  1UMT A;  1RMZ A;  4R3V A;  5D2B A;  1IAB A;  3DNG A;  1DMT A;  3HY9 A;  1CQR A;  1XUR A;  2OI0 A;  4GR0 A;  4H1Q A;  5I2Z A;  1YQY A;  4FVL A;  5CZM A;  1SLN A;  4H82 A;  1SLM A;  3B8Z A;  3LQB A;  1EB6 A;  1KUK A;  3F17 A;  3MA2 A;  4XBH A;  1H71 P;  3CKI A;  1EUB A;  1G49 A;  3LIL A;  5I43 A;  4G0D A;  2JT6 A;  2TCL A;  1IAG A;  2E3X A;  2W13 A;  1G05 A;  3TVC A;  2W12 A;  2XS3 A;  3O64 A;  2OVX A;  2KRJ A;  4XCT A;  2L0R A;  4ON1 A;  2ERO A;  1HFC A;  1QIC A;  4A3W A;  1C8T A;  1BIW A;  3B92 A;  1GO7 P;  1OS9 A;  1ZXV A;  1IAD A;  2OXZ A;  3RTT A;  3LK8 A;  3LGP A;  1JAO A;  2PJT A;  4AUO A;  1CXV A;  3LMC A;  1BZS A;  4IJO A;  1KBC A;  1R1J A;  1MMR A;  2DDF A;  4QKZ A;  1GE5 A;  4Q1L A;  1JAQ A;  3DTI A;  3I7G A;  3U1R A;  4H84 A;  1SAT A;  1SU3 A;  2HU6 A;  3AIG A;  3DTE A;  4A7B A;  966C A;  1TVI A;  1JK3 A;  4JQG A;  3P24 A;  4JIJ A;  3LJG A;  1D5J A;  1CK7 A;  1ATL A;  1GO8 P;  1KAP P;  1QJI A;  4H49 A;  1A86 A;  3V96 B;  2ERQ A;  1Z3J A;  2OW1 A;  4G9L A;  4GUY A;  5B5O A;  3LEA A;  3F15 A;  1WNI A;  1BM6 A;  3LIK A;  3NX7 A;  1MNC A;  4HMA A;  1IAE A;  1MMP A;  1RM8 A;  4PKU A;  3ZUK A;  1HFS A;  1XFY A;  1B3D A;  2JSD A;  3O2X A;  1BUV M;  1IAC A;  1CGL A;  2OZR A;  2J83 A;  4H3X A;  3HDA P;  3Q2H A;  2X3A A;  1K7Q A;  3F1A A;  1XUD A;  1QUA A;  1AF0 A;  1IAA A;  4PKQ A;  2YB9 A;  1FM1 A;  5L79 A;  4XM7 A;  1ZTQ A;  2CLT A;  4XM8 A;  3USN A;  3TS4 A;  3WV3 A;  3SHI A;  2YUF A;  5D1U A;  5JMY A;  1UTT A;  1G9K A;  1ZVX A;  1ZP5 A;  1D8F A;  2W0D A;  1JH1 A;  2X7M A;  3TT4 A;  2SRT A;  2OW0 A;  3KWV C;  1HV5 A;  3EDG A;  1C3I A;  1QJJ A;  3L0T A;  5CUH A;  3BA0 A;  4WKE A;  1PWU A;  3K7L A;  2DW1 A;  5D3C A;  4JA1 A;  4ZR5 A;  3RTS A;  2ERP A;  1C7K A;  4DPE A;  4FXQ A;  2A8H A;  4L63 A;  1KUF A;  4PKV A;  5B5P A;  5I4O A;  4H30 A;  5LAB A;  3G5C A;  1R1I A;  2O36 A;  1OM8 A;  2X3B A;  3EHY A;  1BQO A;  3EDI A;  1PWP A;  1R1H A;  1G4K A;  2OW2 A;  2AIG P;  1JIW P;  2DW2 A;  2K9C A;  3DL1 A;  4GR8 A;  3P1V A;  3KMC A;  4IN9 A;  1XFZ A;  2CKI A;  4DV8 A;  3GBO A;  3LKA A;  4DD8 A;  1JJ9 A;  3HBV P;  1OMJ A;  3AYU A;  1OS2 A;  2MLR A;  4GWN A;  2W14 A;  1PWW A;  4WZV A;  3KEC A;  1JAN A;  2JIH A;  1O0Q A;  3AYK A;  1ND1 A;  3HYG A;  3EHX A;  3TSK A;  4H2E A;  5BOY A;  3L0V A;  2OW9 A;  2DDY A;  3E8R A;  2DW0 A;  1BSW A;  3LJT A;  2I47 A;  3LIR A;  3ELM A;  4XM6 A;  1K7G A;  2JNP A;  3WV1 A;  3WV2 A;  1Y8J A;  3HB2 P;  4AIG A;  1BUD A;  2MLS A;  1S4B P;  1MMB A;  3F18 A;  3EWJ A;  3DPF A;  1GE7 A;  2MZI A;  3DTK A;  3K7N A;  3KHI A;  1HTD A;  1JAP A;  3EDH A;  4WKI A;  3DPE A;  3VI1 A;  4JP4 A;  1XFW A;  4PKT A;  2XS4 A;  1XM5 A;  1MMQ A;  1PWQ A;  3LE9 A;  1QIA A;  1BKC I;  3VTG A;  1KUI A;  1OZ9 A;  2OY4 A;  1XUC A;  1XAX A;  4L19 A;  4DF9 A;  1JKY A;  3G42 A;  1AST A;  2OVZ A;  4ILW D;  5L7F A;  4PKW A;  2O3E A;  1CGF A;  1Y0V A;  2QPJ A;  1FBL A;  1J7N A;  4FXY P;  2N8R A;  2MZH A;  4FU4 A;  3KEJ A;  5D1S A;  3HY7 A;  4PKR A;  1OO9 A;  1XFX A;  1B8Y A;  1K7I A;  2AYK A;  2WO8 A;  4WF6 A;  1JIZ A;  830C A;  1A85 A;  2W15 A;  4EFS A;  2X3C A;  5BPA A;  1O0T A;  1Q3A A;  1HOV A;  1XFU A;  4HX3 A;  3KRY A;  2OXW A;  2OXU A;  1BKC A;  1I1I P;  1AYK A;  3DSL A;  3ZXH A;  1HY7 A;  1L6J A;  1G12 A;  2V4B A;  4JPA A;  3ZVS A;  1PWV A;  4GQL A;  1DTH A;  4H76 A;  3LJZ A;  1I76 A;  3I7I A;  2RJP A;  1GKC A;  3LQ0 A;  1ZXC A;  5D7W A;  2D1O A;  1SRP A;  4WK7 A;  1BQQ M;  1UEA A;  3UVC A;  4AYK A;  5H8X A;  1SMP A;  4L7A A;  2D1N A;  3HBU P;  3HDB A;  4L6T A;  2E2D A;  1ROS A;  5I12 A;  1YCM A;  456C A;  1CGE A;  2J0T A;  2Y6C A;  1UMS A;  3KEK A;  1OM7 A;  4AXQ A;  2Z2D A;  4GWM A;  1CIZ A;  3EDZ A;  4IUW A;  4GF1 A;  4PKS A;  1OM6 A;  1R55 A;  2WO9 A;  4J4M A;  2OY2 A;  2WOA A;  2YIG A;  1D7X A;  5I3M A;  1I73 A;  1EAK A;  1GXD A;  1XFV A;  2K2G A;  2RJQ A;  1UTZ A;  5D1T A;  1AKL A;  1YOU A;  2FV5 A;  1USN A;  4I03 A;  1ZS0 A;  2FV9 A;  4GR3 A;  1CAQ A;  2Y6D A;  3B2Z A;  3N2V A;  1GE6 A;  3DWB A;  3LUN A;  1BKC E;  1Y93 A;  5BOT A;  1GKD A;  1QIB A;  2POJ A;  1KUH A;  1YP1 A;  3OHL A;  2USN A;  5I0L A; 
#chains in the Genus database with same CATH homology
 3F16 A;  3LUM A;  1R54 A;  1FLS A;  4CTH A;  2MZE A;  5CXA A;  1D8M A;  3Q2G A;  3N2U A;  4I35 A;  3F19 A;  1KUG A;  2JT5 A;  3OHO A;  3KME A;  1UMT A;  1RMZ A;  4R3V A;  5D2B A;  1IAB A;  3DNG A;  1DMT A;  3HY9 A;  1CQR A;  1XUR A;  2OI0 A;  4GR0 A;  4H1Q A;  5I2Z A;  1YQY A;  4FVL A;  5CZM A;  1SLN A;  4H82 A;  1SLM A;  3B8Z A;  3LQB A;  1EB6 A;  1KUK A;  3F17 A;  3MA2 A;  4XBH A;  1H71 P;  3CKI A;  1EUB A;  1G49 A;  3LIL A;  5I43 A;  4G0D A;  2JT6 A;  2TCL A;  1IAG A;  2E3X A;  2W13 A;  1G05 A;  3TVC A;  2W12 A;  2XS3 A;  3O64 A;  2OVX A;  2KRJ A;  4XCT A;  2L0R A;  4ON1 A;  2ERO A;  1HFC A;  1QIC A;  4A3W A;  1C8T A;  1BIW A;  3B92 A;  1GO7 P;  1OS9 A;  1ZXV A;  1IAD A;  2OXZ A;  3RTT A;  3LK8 A;  3LGP A;  1JAO A;  2PJT A;  4AUO A;  1CXV A;  3LMC A;  1BZS A;  4IJO A;  1KBC A;  1R1J A;  1MMR A;  2DDF A;  4QKZ A;  1GE5 A;  4Q1L A;  1JAQ A;  3DTI A;  3I7G A;  3U1R A;  4H84 A;  1SAT A;  1SU3 A;  2HU6 A;  3AIG A;  3DTE A;  4A7B A;  966C A;  1JK3 A;  4JQG A;  3P24 A;  4JIJ A;  3LJG A;  1D5J A;  1CK7 A;  1ATL A;  1GO8 P;  1KAP P;  1QJI A;  4H49 A;  1A86 A;  3V96 B;  2ERQ A;  1Z3J A;  2OW1 A;  4G9L A;  4GUY A;  5B5O A;  3LEA A;  3F15 A;  1WNI A;  1BM6 A;  3LIK A;  3NX7 A;  1MNC A;  4HMA A;  1IAE A;  1MMP A;  1RM8 A;  4PKU A;  3ZUK A;  1HFS A;  1XFY A;  1B3D A;  2JSD A;  3O2X A;  1BUV M;  1IAC A;  1CGL A;  2OZR A;  2J83 A;  4H3X A;  3HDA P;  3Q2H A;  2X3A A;  1K7Q A;  3F1A A;  1XUD A;  1QUA A;  1AF0 A;  1IAA A;  4PKQ A;  2YB9 A;  1FM1 A;  5L79 A;  4XM7 A;  1ZTQ A;  2CLT A;  4XM8 A;  3USN A;  3TS4 A;  3WV3 A;  3SHI A;  2YUF A;  5D1U A;  5JMY A;  1UTT A;  1G9K A;  1ZVX A;  1ZP5 A;  1D8F A;  2W0D A;  1JH1 A;  2X7M A;  3TT4 A;  2SRT A;  2OW0 A;  3KWV C;  1HV5 A;  3EDG A;  1C3I A;  1QJJ A;  3L0T A;  5CUH A;  3BA0 A;  4WKE A;  1PWU A;  3K7L A;  2DW1 A;  5D3C A;  4JA1 A;  4ZR5 A;  3RTS A;  2ERP A;  1C7K A;  4DPE A;  4FXQ A;  2A8H A;  4L63 A;  1KUF A;  4PKV A;  5B5P A;  5I4O A;  4H30 A;  5LAB A;  3G5C A;  1R1I A;  2O36 A;  1OM8 A;  2X3B A;  3EHY A;  1BQO A;  3EDI A;  1PWP A;  1R1H A;  1G4K A;  2OW2 A;  2AIG P;  1JIW P;  2DW2 A;  2K9C A;  3DL1 A;  4GR8 A;  3P1V A;  3KMC A;  4IN9 A;  1XFZ A;  2CKI A;  4DV8 A;  3GBO A;  3LKA A;  4DD8 A;  1JJ9 A;  3HBV P;  1OMJ A;  3AYU A;  1OS2 A;  2MLR A;  4GWN A;  2W14 A;  1PWW A;  4WZV A;  3KEC A;  1JAN A;  2JIH A;  1O0Q A;  3AYK A;  1ND1 A;  3HYG A;  3EHX A;  3TSK A;  4H2E A;  5BOY A;  3L0V A;  2OW9 A;  2DDY A;  3E8R A;  2DW0 A;  1BSW A;  3LJT A;  2I47 A;  3LIR A;  3ELM A;  4XM6 A;  1K7G A;  2JNP A;  3WV1 A;  3WV2 A;  1Y8J A;  3HB2 P;  4AIG A;  1BUD A;  2MLS A;  1S4B P;  1MMB A;  3F18 A;  3EWJ A;  3DPF A;  1GE7 A;  2MZI A;  3DTK A;  3K7N A;  3KHI A;  1HTD A;  1JAP A;  3EDH A;  4WKI A;  3DPE A;  3VI1 A;  4JP4 A;  1XFW A;  4PKT A;  2XS4 A;  1MMQ A;  1PWQ A;  3LE9 A;  1QIA A;  1BKC I;  3VTG A;  1KUI A;  2OY4 A;  1XUC A;  4L19 A;  4DF9 A;  1JKY A;  3G42 A;  1AST A;  2OVZ A;  4ILW D;  5L7F A;  4PKW A;  2O3E A;  1CGF A;  1Y0V A;  2QPJ A;  1FBL A;  1J7N A;  4FXY P;  2N8R A;  2MZH A;  4FU4 A;  3KEJ A;  5D1S A;  3HY7 A;  4PKR A;  1OO9 A;  1XFX A;  1B8Y A;  1K7I A;  2AYK A;  2WO8 A;  4WF6 A;  1JIZ A;  830C A;  1A85 A;  2W15 A;  4EFS A;  2X3C A;  5BPA A;  1O0T A;  1Q3A A;  1HOV A;  1XFU A;  4HX3 A;  3KRY A;  2OXW A;  2OXU A;  1BKC A;  1I1I P;  1AYK A;  3DSL A;  3ZXH A;  1HY7 A;  1L6J A;  1G12 A;  2V4B A;  4JPA A;  3ZVS A;  1PWV A;  4GQL A;  1DTH A;  4H76 A;  3LJZ A;  1I76 A;  3I7I A;  2RJP A;  1GKC A;  3LQ0 A;  1ZXC A;  5D7W A;  2D1O A;  1SRP A;  4WK7 A;  1BQQ M;  1UEA A;  3UVC A;  4AYK A;  5H8X A;  1SMP A;  4L7A A;  2D1N A;  3HBU P;  3HDB A;  4L6T A;  2E2D A;  1ROS A;  5I12 A;  1YCM A;  456C A;  1CGE A;  2J0T A;  2Y6C A;  1UMS A;  3KEK A;  1OM7 A;  4AXQ A;  2Z2D A;  4GWM A;  1CIZ A;  3EDZ A;  4IUW A;  4GF1 A;  4PKS A;  1OM6 A;  1R55 A;  2WO9 A;  4J4M A;  2OY2 A;  2WOA A;  2YIG A;  1D7X A;  5I3M A;  1I73 A;  1EAK A;  1GXD A;  1XFV A;  2K2G A;  2RJQ A;  1UTZ A;  5D1T A;  1AKL A;  1YOU A;  2FV5 A;  1USN A;  4I03 A;  1ZS0 A;  2FV9 A;  4GR3 A;  1CAQ A;  2Y6D A;  3B2Z A;  3N2V A;  1GE6 A;  3DWB A;  3LUN A;  1BKC E;  1Y93 A;  5BOT A;  1GKD A;  1QIB A;  2POJ A;  1KUH A;  1YP1 A;  3OHL A;  2USN A;  5I0L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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