3IGZB

Crystal structures of leishmania mexicana phosphoglycerate mutase at low cobalt concentration
Total Genus 207
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
207
Knots found
sequence length
549
structure length
549
Chain Sequence
LLLKPHKDLPRRTVLIVVMDGLGIGPEDDYDAVHMASTPFMDAHRRDNRHFRCVRAHGTAVGLPTDADMGNSEVGHNALGAGRVALQGASLVDDAIKSGEIYTGEGYRYLHGAFSKEGSTLHLIGLLSDGGVHSRDNQIYSIIEHAVKDGAKRIRVHALYDGRDVPDGSSFRFTDELEAVLAKVRQNGCDAAIASGGGRMFVTMDRYDADWSIVERGWRAQVLGDARHFHSAKEAITTFREEDPKVTDQYYPPFIVVDEQDKPLGTIEDGDAVLCVNFRGDRVIEMTRAFEDEDFNKFDRVRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNIFACSETQKFGHVTYFWNGNRSGKIDEKHETFKEVPSDRVQFNEKPRMQSAAITEAAIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGVEAVDESLAKLKDAVDSVNGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTSHTLSPVPVFIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPEDYEPSLIYVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
pubmed doi rcsb
source organism Leishmania mexicana
molecule tags Isomerase
molecule keywords Cofactor-independent phosphoglycerate mutase
total genus 207
structure length 549
sequence length 549
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.1: Transferred entry: 5.4.2.11 and 5.4.2.12.
pdb deposition date 2009-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01676 Metalloenzyme Metalloenzyme superfamily
B PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3igzB01
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 3igzB02
2W5SA 4FDJA 4KM4A 5IJSA 1ALIA 1ED9A 2RH6A 2VQRA 3NKPA 3SZYA 3M7VA 5TJ3A 3UN5A 3UO0A 1ZEFA 2IUCB 3M8WA 3OT9A 1ZEDA 4UPLA 5LQQA 2GSOA 4LR9A 4TN0A 4MHXA 3TWZA 4CYSA 3SZZA 5L0EA 5L0BA 2QZUA 1O99A 4KJDA 4LRAA 1ED8A 2GSUA 4GTXA 1SHNA 1ALHA 4NWXA 1URBA 3KD8A 5EGEA 4UOPA 4FDIA 3IGYB 5AJ9A 3T00A 4UOOA 1EW2A 1KH5A 3MK1A 3UNYA 4LR7A 3IDDA 3WBHA 3ED4A 5C66A 2XR9A 5K4PA 1AUKA 3A52A 1EW8A 3NKRA 4ZG6A 4KJGA 3WAWA 2W5VA 2W5WA 3M8YA 4UPIA 1HDHA 1HQAA 2W5RA 5IJQA 1ZEBA 1ANIA 5LRMA 1ALKA 5DLTA 3WAXA 3NKNA 4MY4A 1E2SP 1N2LA 1ALJA 3NVLA 3E2DA 1KH7A 1EJJA 3IGZB 4UPHA 4CXSA 2ANHA 1FSUA 1B8JA 5L0KA 1ELYA 3TX0A 1E1ZP 4LRCA 4CXKA 4GTWA 5HRTA 2W5QA 4KAVA 5KXAA 4CXUA 1EW9A 2GA3A 2GSNA 3UN2A 3BDGB 4MIVA 3BDGA 5EGHA 2G9YA 1ELZA 1AJAA 1KH4A 2W8SA 3DPCA 4LRBA 2IUCA 2W5XA 3T02A 4GTZA 3LXQA 1ANJA 5INHA 3WAVA 1N2KA 1E3CP 1URAA 1E33P 3NKQA 2IFYA 1KHKA 2ZKTA 4LRDA 4ZGAA 2D1GA 1Y6VA 4CYRA 5DLVA 3MK2A 3CMRA 1KHNA 4UORA 3M8ZA 1ELXA 3WAYA 3NKMA 1KHLA 4LQYA 1HJKA 5GRRA 2GLQA 4B56A 3T01A 4N7TA 5LIAA 2XRGA 1KHJA 1AJBA 4GTYA 5GOVA 2W5TA 3NKOA 3DYCA 4UPKA 4KAYA 2X98A 4LR2A 1EQJA 1KH9A 1SHQA 4NWJA 4YR1A 1K7HA 4ZG7A 1Y7AA 3BDFA 1EI6A 1AJDA 1P49A 4QAXA 5LRNA 3BDHA 4LR8A 4ZG9A 2W8DA 1AJCA 3TG0A 3Q3QA 3B5QA 3UN3A 5DLWA 1O98A 4LRFA 3MK0A 4LREA
chains in the Genus database with same CATH superfamily
2W5SA 4FDJA 4KM4A 5IJSA 1ALIA 1ED9A 2RH6A 2VQRA 3NKPA 3SZYA 3M7VA 5TJ3A 3UN5A 3UO0A 1ZEFA 2IUCB 3M8WA 3OT9A 1ZEDA 4UPLA 5LQQA 2GSOA 4LR9A 4TN0A 4MHXA 3TWZA 4CYSA 3SZZA 5L0EA 5L0BA 2QZUA 1O99A 4KJDA 4LRAA 1ED8A 2GSUA 4GTXA 1SHNA 1ALHA 4NWXA 1URBA 3KD8A 5EGEA 4UOPA 4FDIA 3IGYB 5AJ9A 3T00A 4UOOA 1EW2A 1KH5A 3MK1A 3UNYA 4LR7A 3IDDA 3WBHA 3ED4A 5C66A 2XR9A 5K4PA 1AUKA 3A52A 1EW8A 3NKRA 4ZG6A 4KJGA 3WAWA 2W5VA 2W5WA 3M8YA 4UPIA 1HDHA 1HQAA 2W5RA 5IJQA 1ZEBA 1ANIA 5LRMA 1ALKA 5DLTA 3WAXA 3NKNA 4MY4A 1E2SP 1N2LA 1ALJA 3NVLA 3E2DA 1KH7A 1EJJA 3IGZB 4UPHA 4CXSA 2ANHA 1FSUA 1B8JA 5L0KA 1ELYA 3TX0A 1E1ZP 4LRCA 4CXKA 4GTWA 5HRTA 2W5QA 4KAVA 5KXAA 4CXUA 1EW9A 2GA3A 2GSNA 3UN2A 3BDGB 4MIVA 3BDGA 5EGHA 2G9YA 1ELZA 1AJAA 1KH4A 2W8SA 3DPCA 4LRBA 2IUCA 2W5XA 3T02A 4GTZA 3LXQA 1ANJA 5INHA 3WAVA 1N2KA 1E3CP 1URAA 1E33P 3NKQA 2IFYA 1KHKA 2ZKTA 4LRDA 4ZGAA 2D1GA 1Y6VA 4CYRA 5DLVA 3MK2A 3CMRA 1KHNA 4UORA 3M8ZA 1ELXA 3WAYA 3NKMA 1KHLA 4LQYA 1HJKA 5GRRA 2GLQA 4B56A 3T01A 4N7TA 5LIAA 2XRGA 1KHJA 1AJBA 4GTYA 5GOVA 2W5TA 3NKOA 3DYCA 4UPKA 4KAYA 2X98A 4LR2A 1EQJA 1KH9A 1SHQA 4NWJA 4YR1A 1K7HA 4ZG7A 1Y7AA 3BDFA 1EI6A 1AJDA 1P49A 4QAXA 5LRNA 3BDHA 4LR8A 4ZG9A 2W8DA 1AJCA 3TG0A 3Q3QA 3B5QA 3UN3A 5DLWA 1O98A 4LRFA 3MK0A 4LREA
chains in the Genus database with same CATH topology
2W5SA 4FDJA 4KM4A 5IJSA 1ALIA 1ED9A 2RH6A 2VQRA 3NKPA 3SZYA 3M7VA 5TJ3A 3UN5A 3UO0A 1ZEFA 2IUCB 3M8WA 3OT9A 1ZEDA 4UPLA 5LQQA 2GSOA 4LR9A 4TN0A 4MHXA 3TWZA 4CYSA 3SZZA 5L0EA 5L0BA 2QZUA 1O99A 4KJDA 4LRAA 1ED8A 2GSUA 4GTXA 1SHNA 1ALHA 4NWXA 1URBA 3KD8A 5EGEA 4UOPA 4FDIA 3IGYB 5AJ9A 3T00A 4UOOA 1EW2A 1KH5A 3MK1A 3UNYA 4LR7A 3IDDA 3WBHA 3ED4A 5C66A 2XR9A 5K4PA 1AUKA 3A52A 1EW8A 3NKRA 4ZG6A 4KJGA 3WAWA 2W5VA 2W5WA 3M8YA 4UPIA 1HDHA 1HQAA 2W5RA 5IJQA 1ZEBA 1ANIA 5LRMA 1ALKA 5DLTA 3WAXA 3NKNA 4MY4A 1E2SP 1N2LA 1ALJA 3NVLA 3E2DA 1KH7A 1EJJA 3IGZB 4UPHA 4CXSA 2ANHA 1FSUA 1B8JA 5L0KA 1ELYA 3TX0A 1E1ZP 4LRCA 4CXKA 4GTWA 5HRTA 2W5QA 4KAVA 5KXAA 4CXUA 1EW9A 2GA3A 2GSNA 3UN2A 3BDGB 4MIVA 3BDGA 5EGHA 2G9YA 1ELZA 1AJAA 1KH4A 2W8SA 3DPCA 4LRBA 2IUCA 2W5XA 3T02A 4GTZA 3LXQA 1ANJA 5INHA 3WAVA 1N2KA 1E3CP 1URAA 1E33P 3NKQA 2IFYA 1KHKA 2ZKTA 4LRDA 4ZGAA 2D1GA 1Y6VA 4CYRA 5DLVA 3MK2A 3CMRA 1KHNA 4UORA 3M8ZA 1ELXA 3WAYA 3NKMA 1KHLA 4LQYA 1HJKA 5GRRA 2GLQA 4B56A 3T01A 4N7TA 5LIAA 2XRGA 1KHJA 1AJBA 4GTYA 5GOVA 2W5TA 3NKOA 3DYCA 4UPKA 4KAYA 2X98A 4LR2A 1EQJA 1KH9A 1SHQA 4NWJA 4YR1A 1K7HA 4ZG7A 1Y7AA 3BDFA 1EI6A 1AJDA 1P49A 4QAXA 5LRNA 3BDHA 4LR8A 4ZG9A 2W8DA 1AJCA 3TG0A 3Q3QA 3B5QA 3UN3A 5DLWA 1O98A 4LRFA 3MK0A 4LREA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W5S A;  4FDJ A;  4KM4 A;  5IJS A;  1ALI A;  1ED9 A;  2RH6 A;  2VQR A;  3NKP A;  3SZY A;  3M7V A;  5TJ3 A;  3UN5 A;  3UO0 A;  1ZEF A;  2IUC B;  3M8W A;  3OT9 A;  1ZED A;  4UPL A;  5LQQ A;  2GSO A;  4LR9 A;  4TN0 A;  4MHX A;  3TWZ A;  4CYS A;  3SZZ A;  5L0E A;  5L0B A;  2QZU A;  1O99 A;  4KJD A;  4LRA A;  1ED8 A;  2GSU A;  4GTX A;  1SHN A;  1ALH A;  4NWX A;  1URB A;  3KD8 A;  5EGE A;  4UOP A;  4FDI A;  3IGY B;  5AJ9 A;  3T00 A;  4UOO A;  1EW2 A;  1KH5 A;  3MK1 A;  3UNY A;  4LR7 A;  3IDD A;  3WBH A;  3ED4 A;  5C66 A;  2XR9 A;  5K4P A;  1AUK A;  3A52 A;  1EW8 A;  3NKR A;  4ZG6 A;  4KJG A;  3WAW A;  2W5V A;  2W5W A;  3M8Y A;  4UPI A;  1HDH A;  1HQA A;  2W5R A;  5IJQ A;  1ZEB A;  1ANI A;  5LRM A;  1ALK A;  5DLT A;  3WAX A;  3NKN A;  4MY4 A;  1E2S P;  1N2L A;  1ALJ A;  3NVL A;  3E2D A;  1KH7 A;  1EJJ A;  3IGZ B;  4UPH A;  4CXS A;  2ANH A;  1FSU A;  1B8J A;  5L0K A;  1ELY A;  3TX0 A;  1E1Z P;  4LRC A;  4CXK A;  4GTW A;  5HRT A;  2W5Q A;  4KAV A;  5KXA A;  4CXU A;  1EW9 A;  2GA3 A;  2GSN A;  3UN2 A;  3BDG B;  4MIV A;  3BDG A;  5EGH A;  2G9Y A;  1ELZ A;  1AJA A;  1KH4 A;  2W8S A;  3DPC A;  4LRB A;  2IUC A;  2W5X A;  3T02 A;  4GTZ A;  3LXQ A;  1ANJ A;  5INH A;  3WAV A;  1N2K A;  1E3C P;  1URA A;  1E33 P;  3NKQ A;  2IFY A;  1KHK A;  2ZKT A;  4LRD A;  4ZGA A;  2D1G A;  1Y6V A;  4CYR A;  5DLV A;  3MK2 A;  3CMR A;  1KHN A;  4UOR A;  3M8Z A;  1ELX A;  3WAY A;  3NKM A;  1KHL A;  4LQY A;  1HJK A;  5GRR A;  2GLQ A;  4B56 A;  3T01 A;  4N7T A;  5LIA A;  2XRG A;  1KHJ A;  1AJB A;  4GTY A;  5GOV A;  2W5T A;  3NKO A;  3DYC A;  4UPK A;  4KAY A;  2X98 A;  4LR2 A;  1EQJ A;  1KH9 A;  1SHQ A;  4NWJ A;  4YR1 A;  1K7H A;  4ZG7 A;  1Y7A A;  3BDF A;  1EI6 A;  1AJD A;  1P49 A;  4QAX A;  5LRN A;  3BDH A;  4LR8 A;  4ZG9 A;  2W8D A;  1AJC A;  3TG0 A;  3Q3Q A;  3B5Q A;  3UN3 A;  5DLW A;  1O98 A;  4LRF A;  3MK0 A;  4LRE A; 
#chains in the Genus database with same CATH topology
 2W5S A;  4FDJ A;  4KM4 A;  5IJS A;  1ALI A;  1ED9 A;  2RH6 A;  2VQR A;  3NKP A;  3SZY A;  3M7V A;  5TJ3 A;  3UN5 A;  3UO0 A;  1ZEF A;  2IUC B;  3M8W A;  3OT9 A;  1ZED A;  4UPL A;  5LQQ A;  2GSO A;  4LR9 A;  4TN0 A;  4MHX A;  3TWZ A;  4CYS A;  3SZZ A;  5L0E A;  5L0B A;  2QZU A;  1O99 A;  4KJD A;  4LRA A;  1ED8 A;  2GSU A;  4GTX A;  1SHN A;  1ALH A;  4NWX A;  1URB A;  3KD8 A;  5EGE A;  4UOP A;  4FDI A;  3IGY B;  5AJ9 A;  3T00 A;  4UOO A;  1EW2 A;  1KH5 A;  3MK1 A;  3UNY A;  4LR7 A;  3IDD A;  3WBH A;  3ED4 A;  5C66 A;  2XR9 A;  5K4P A;  1AUK A;  3A52 A;  1EW8 A;  3NKR A;  4ZG6 A;  4KJG A;  3WAW A;  2W5V A;  2W5W A;  3M8Y A;  4UPI A;  1HDH A;  1HQA A;  2W5R A;  5IJQ A;  1ZEB A;  1ANI A;  5LRM A;  1ALK A;  5DLT A;  3WAX A;  3NKN A;  4MY4 A;  1E2S P;  1N2L A;  1ALJ A;  3NVL A;  3E2D A;  1KH7 A;  1EJJ A;  3IGZ B;  4UPH A;  4CXS A;  2ANH A;  1FSU A;  1B8J A;  5L0K A;  1ELY A;  3TX0 A;  1E1Z P;  4LRC A;  4CXK A;  4GTW A;  5HRT A;  2W5Q A;  4KAV A;  5KXA A;  4CXU A;  1EW9 A;  2GA3 A;  2GSN A;  3UN2 A;  3BDG B;  4MIV A;  3BDG A;  5EGH A;  2G9Y A;  1ELZ A;  1AJA A;  1KH4 A;  2W8S A;  3DPC A;  4LRB A;  2IUC A;  2W5X A;  3T02 A;  4GTZ A;  3LXQ A;  1ANJ A;  5INH A;  3WAV A;  1N2K A;  1E3C P;  1URA A;  1E33 P;  3NKQ A;  2IFY A;  1KHK A;  2ZKT A;  4LRD A;  4ZGA A;  2D1G A;  1Y6V A;  4CYR A;  5DLV A;  3MK2 A;  3CMR A;  1KHN A;  4UOR A;  3M8Z A;  1ELX A;  3WAY A;  3NKM A;  1KHL A;  4LQY A;  1HJK A;  5GRR A;  2GLQ A;  4B56 A;  3T01 A;  4N7T A;  5LIA A;  2XRG A;  1KHJ A;  1AJB A;  4GTY A;  5GOV A;  2W5T A;  3NKO A;  3DYC A;  4UPK A;  4KAY A;  2X98 A;  4LR2 A;  1EQJ A;  1KH9 A;  1SHQ A;  4NWJ A;  4YR1 A;  1K7H A;  4ZG7 A;  1Y7A A;  3BDF A;  1EI6 A;  1AJD A;  1P49 A;  4QAX A;  5LRN A;  3BDH A;  4LR8 A;  4ZG9 A;  2W8D A;  1AJC A;  3TG0 A;  3Q3Q A;  3B5Q A;  3UN3 A;  5DLW A;  1O98 A;  4LRF A;  3MK0 A;  4LRE A; 
#chains in the Genus database with same CATH homology
 2W5S A;  4FDJ A;  4KM4 A;  5IJS A;  1ALI A;  1ED9 A;  2RH6 A;  2VQR A;  3NKP A;  3SZY A;  3M7V A;  5TJ3 A;  3UN5 A;  3UO0 A;  1ZEF A;  2IUC B;  3M8W A;  3OT9 A;  1ZED A;  4UPL A;  5LQQ A;  2GSO A;  4LR9 A;  4TN0 A;  4MHX A;  3TWZ A;  4CYS A;  3SZZ A;  5L0E A;  5L0B A;  2QZU A;  1O99 A;  4KJD A;  4LRA A;  1ED8 A;  2GSU A;  4GTX A;  1SHN A;  1ALH A;  4NWX A;  1URB A;  3KD8 A;  5EGE A;  4UOP A;  4FDI A;  3IGY B;  5AJ9 A;  3T00 A;  4UOO A;  1EW2 A;  1KH5 A;  3MK1 A;  3UNY A;  4LR7 A;  3IDD A;  3WBH A;  3ED4 A;  5C66 A;  2XR9 A;  5K4P A;  1AUK A;  3A52 A;  1EW8 A;  3NKR A;  4ZG6 A;  4KJG A;  3WAW A;  2W5V A;  2W5W A;  3M8Y A;  4UPI A;  1HDH A;  1HQA A;  2W5R A;  5IJQ A;  1ZEB A;  1ANI A;  5LRM A;  1ALK A;  5DLT A;  3WAX A;  3NKN A;  4MY4 A;  1E2S P;  1N2L A;  1ALJ A;  3NVL A;  3E2D A;  1KH7 A;  1EJJ A;  3IGZ B;  4UPH A;  4CXS A;  2ANH A;  1FSU A;  1B8J A;  5L0K A;  1ELY A;  3TX0 A;  1E1Z P;  4LRC A;  4CXK A;  4GTW A;  5HRT A;  2W5Q A;  4KAV A;  5KXA A;  4CXU A;  1EW9 A;  2GA3 A;  2GSN A;  3UN2 A;  3BDG B;  4MIV A;  3BDG A;  5EGH A;  2G9Y A;  1ELZ A;  1AJA A;  1KH4 A;  2W8S A;  3DPC A;  4LRB A;  2IUC A;  2W5X A;  3T02 A;  4GTZ A;  3LXQ A;  1ANJ A;  5INH A;  3WAV A;  1N2K A;  1E3C P;  1URA A;  1E33 P;  3NKQ A;  2IFY A;  1KHK A;  2ZKT A;  4LRD A;  4ZGA A;  2D1G A;  1Y6V A;  4CYR A;  5DLV A;  3MK2 A;  3CMR A;  1KHN A;  4UOR A;  3M8Z A;  1ELX A;  3WAY A;  3NKM A;  1KHL A;  4LQY A;  1HJK A;  5GRR A;  2GLQ A;  4B56 A;  3T01 A;  4N7T A;  5LIA A;  2XRG A;  1KHJ A;  1AJB A;  4GTY A;  5GOV A;  2W5T A;  3NKO A;  3DYC A;  4UPK A;  4KAY A;  2X98 A;  4LR2 A;  1EQJ A;  1KH9 A;  1SHQ A;  4NWJ A;  4YR1 A;  1K7H A;  4ZG7 A;  1Y7A A;  3BDF A;  1EI6 A;  1AJD A;  1P49 A;  4QAX A;  5LRN A;  3BDH A;  4LR8 A;  4ZG9 A;  2W8D A;  1AJC A;  3TG0 A;  3Q3Q A;  3B5Q A;  3UN3 A;  5DLW A;  1O98 A;  4LRF A;  3MK0 A;  4LRE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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