3JAKM

Cryo-em structure of gtpgammas-microtubule co-polymerized with eb3 (merged dataset with and without kinesin bound)
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
131
structure length
131
Chain Sequence
MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Tubulin alpha-1B chain
total genus 34
structure length 131
sequence length 131
chains with identical sequence N
ec nomenclature
pdb deposition date 2015-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
M PF00307 CH Calponin homology (CH) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.418.10 Mainly Alpha Orthogonal Bundle Actin-binding Protein, T-fimbrin; domain 1 Calponin-like domain 3jakM00
1WKUA 3HOCA 4EDNA 2E9KA 1WYMA 1DXXA 2VZDA 1PXYA 2VZGB 2D88A 1H67A 1PA7A 2RR8A 1WJOA 2D87A 2D86A 1BHDA 1UEGA 1TJTA 4TXKA 2QJZA 3FERA 1BKRA 2WA5A 3HOPA 5A38A 2EE7A 1WYQA 4EDMA 2R0OA 2R8UA 4Q58A 1AOAA 2JV9A 3KY9A 2EYNA 1WYOA 3JARM 4TXIA 2K2RA 5L0OA 2DK9A 1MB8A 2YRNA 4B7LA 2L3GA 2D89A 4Q57B 1WYPA 1WYRA 3F7PA 3CO1A 3KMWB 4EDLA 1RT8A 3JALM 1UJOA 2K3SA 2WFNA 1WYNA 2EYIA 3HORA 5A36A 1AA2A 2WA6A 5BVRA 3REPB 5A4BA 5J8EA 5A37A 1VKAA 1P2XA 3KMUB 3JAKM 4Q59A 2VZIB 1P5SA 2D85A 1WYLA 1WIXA 2WA7A 1V5KA 3I6XA 2VZCA 1QAGA 1SH5A 1SH6A 2QJXA
chains in the Genus database with same CATH superfamily
1WKUA 4LVPA 3HOCA 4EDNA 5FMTA 2E9KA 1WYMA 1DXXA 2VZDA 1PXYA 2VZGB 2D88A 1H67A 1PA7A 2RR8A 1WJOA 2D87A 2D86A 1BHDA 1UEGA 1TJTA 4TXKA 2QJZA 3FERA 1BKRA 2WA5A 2EQOA 3HOPA 5A38A 2EE7A 1WYQA 4EDMA 3VP7A 2R0OA 2R8UA 4Q58A 1AOAA 2HL9A 2JV9A 3KY9A 2EYNA 1WYOA 3JARM 4TXIA 2K2RA 5L0OA 2DK9A 1MB8A 2YRNA 4B7LA 2L3GA 2D89A 4Q57B 1WYPA 1WYRA 2WDTA 3F7PA 2WE6A 3CO1A 3KMWB 4EDLA 1RT8A 3JALM 1UJOA 2K3SA 2IGPA 2WFNA 1WYNA 5FMUA 2EYIA 3HORA 4DDPA 5A36A 2VE7C 1AA2A 2WA6A 5BVRA 3EAYA 3REPB 5A4BA 5J8EA 5A37A 2HKPA 1VKAA 1EUVA 1P2XA 3KMUB 3JAKM 2VE7A 2VZIB 4Q59A 1P5SA 2D85A 1WYLA 1WIXA 2WA7A 4LVRA 1V5KA 3I6XA 2VZCA 1QAGA 2HL8A 1SH5A 1SH6A 2QJXA
chains in the Genus database with same CATH topology
1WKUA 3HOCA 4EDNA 2E9KA 1WYMA 1DXXA 2VZDA 1PXYA 2VZGB 2D88A 1H67A 1PA7A 2RR8A 1WJOA 2D87A 2D86A 1BHDA 1UEGA 1TJTA 4TXKA 2QJZA 3FERA 1BKRA 2WA5A 3HOPA 5A38A 2EE7A 1WYQA 4EDMA 2R0OA 2R8UA 4Q58A 1AOAA 2JV9A 3KY9A 2EYNA 1WYOA 3JARM 4TXIA 2K2RA 5L0OA 2DK9A 1MB8A 2YRNA 4B7LA 2L3GA 2D89A 4Q57B 1WYPA 1WYRA 3F7PA 3CO1A 3KMWB 4EDLA 1RT8A 3JALM 1UJOA 2K3SA 2WFNA 1WYNA 2EYIA 3HORA 5A36A 1AA2A 2WA6A 5BVRA 3REPB 5A4BA 5J8EA 5A37A 1VKAA 1P2XA 3KMUB 3JAKM 4Q59A 2VZIB 1P5SA 2D85A 1WYLA 1WIXA 2WA7A 1V5KA 3I6XA 2VZCA 1QAGA 1SH5A 1SH6A 2QJXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WKU A;  3HOC A;  4EDN A;  2E9K A;  1WYM A;  1DXX A;  2VZD A;  1PXY A;  2VZG B;  2D88 A;  1H67 A;  1PA7 A;  2RR8 A;  1WJO A;  2D87 A;  2D86 A;  1BHD A;  1UEG A;  1TJT A;  4TXK A;  2QJZ A;  3FER A;  1BKR A;  2WA5 A;  3HOP A;  5A38 A;  2EE7 A;  1WYQ A;  4EDM A;  2R0O A;  2R8U A;  4Q58 A;  1AOA A;  2JV9 A;  3KY9 A;  2EYN A;  1WYO A;  3JAR M;  4TXI A;  2K2R A;  5L0O A;  2DK9 A;  1MB8 A;  2YRN A;  4B7L A;  2L3G A;  2D89 A;  4Q57 B;  1WYP A;  1WYR A;  3F7P A;  3CO1 A;  3KMW B;  4EDL A;  1RT8 A;  3JAL M;  1UJO A;  2K3S A;  2WFN A;  1WYN A;  2EYI A;  3HOR A;  5A36 A;  1AA2 A;  2WA6 A;  5BVR A;  3REP B;  5A4B A;  5J8E A;  5A37 A;  1VKA A;  1P2X A;  3KMU B;  3JAK M;  4Q59 A;  2VZI B;  1P5S A;  2D85 A;  1WYL A;  1WIX A;  2WA7 A;  1V5K A;  3I6X A;  2VZC A;  1QAG A;  1SH5 A;  1SH6 A;  2QJX A; 
#chains in the Genus database with same CATH topology
 1WKU A;  4LVP A;  3HOC A;  4EDN A;  5FMT A;  2E9K A;  1WYM A;  1DXX A;  2VZD A;  1PXY A;  2VZG B;  2D88 A;  1H67 A;  1PA7 A;  2RR8 A;  1WJO A;  2D87 A;  2D86 A;  1BHD A;  1UEG A;  1TJT A;  4TXK A;  2QJZ A;  3FER A;  1BKR A;  2WA5 A;  2EQO A;  3HOP A;  5A38 A;  2EE7 A;  1WYQ A;  4EDM A;  3VP7 A;  2R0O A;  2R8U A;  4Q58 A;  1AOA A;  2HL9 A;  2JV9 A;  3KY9 A;  2EYN A;  1WYO A;  3JAR M;  4TXI A;  2K2R A;  5L0O A;  2DK9 A;  1MB8 A;  2YRN A;  4B7L A;  2L3G A;  2D89 A;  4Q57 B;  1WYP A;  1WYR A;  2WDT A;  3F7P A;  2WE6 A;  3CO1 A;  3KMW B;  4EDL A;  1RT8 A;  3JAL M;  1UJO A;  2K3S A;  2IGP A;  2WFN A;  1WYN A;  5FMU A;  2EYI A;  3HOR A;  4DDP A;  5A36 A;  2VE7 C;  1AA2 A;  2WA6 A;  5BVR A;  3EAY A;  3REP B;  5A4B A;  5J8E A;  5A37 A;  2HKP A;  1VKA A;  1EUV A;  1P2X A;  3KMU B;  3JAK M;  2VE7 A;  2VZI B;  4Q59 A;  1P5S A;  2D85 A;  1WYL A;  1WIX A;  2WA7 A;  4LVR A;  1V5K A;  3I6X A;  2VZC A;  1QAG A;  2HL8 A;  1SH5 A;  1SH6 A;  2QJX A; 
#chains in the Genus database with same CATH homology
 1WKU A;  3HOC A;  4EDN A;  2E9K A;  1WYM A;  1DXX A;  2VZD A;  1PXY A;  2VZG B;  2D88 A;  1H67 A;  1PA7 A;  2RR8 A;  1WJO A;  2D87 A;  2D86 A;  1BHD A;  1UEG A;  1TJT A;  4TXK A;  2QJZ A;  3FER A;  1BKR A;  2WA5 A;  3HOP A;  5A38 A;  2EE7 A;  1WYQ A;  4EDM A;  2R0O A;  2R8U A;  4Q58 A;  1AOA A;  2JV9 A;  3KY9 A;  2EYN A;  1WYO A;  3JAR M;  4TXI A;  2K2R A;  5L0O A;  2DK9 A;  1MB8 A;  2YRN A;  4B7L A;  2L3G A;  2D89 A;  4Q57 B;  1WYP A;  1WYR A;  3F7P A;  3CO1 A;  3KMW B;  4EDL A;  1RT8 A;  3JAL M;  1UJO A;  2K3S A;  2WFN A;  1WYN A;  2EYI A;  3HOR A;  5A36 A;  1AA2 A;  2WA6 A;  5BVR A;  3REP B;  5A4B A;  5J8E A;  5A37 A;  1VKA A;  1P2X A;  3KMU B;  3JAK M;  4Q59 A;  2VZI B;  1P5S A;  2D85 A;  1WYL A;  1WIX A;  2WA7 A;  1V5K A;  3I6X A;  2VZC A;  1QAG A;  1SH5 A;  1SH6 A;  2QJX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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