3JC62

Structure of the eukaryotic replicative cmg helicase and pumpjack motion
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
260
structure length
241
Chain Sequence
PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLLGPFFQDSNEEIRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
pubmed doi rcsb
molecule tags Replication
source organism Saccharomyces cerevisiae
molecule keywords DNA replication licensing factor MCM2
total genus 34
structure length 241
sequence length 260
ec nomenclature ec 3.6.4.12: DNA helicase.
pdb deposition date 2015-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
2 PF00493 MCM MCM P-loop domain
2 PF12619 MCM2_N Mini-chromosome maintenance protein 2
2 PF14551 MCM_N MCM N-terminal domain
2 PF17207 MCM_OB MCM OB domain
2 PF17855 MCM_lid MCM AAA-lid domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1640.10 Alpha Beta 2-Layer Sandwich mini-chromosome maintenance (MCM) complex, chain A, domain 1 mini-chromosome maintenance (MCM) complex, chain A, domain 1 3jc6201
4POFA 3JC63 3JC62 4YWLA 4POGA 2VL6A 4ME3A 1LTLA 3JC66 5IY0A 4YWKA 4YWMA
chains in the Genus database with same CATH superfamily
4POFA 3F8TA 3JC62 3JC63 4YWLA 4POGA 2VL6A 4ME3A 1LTLA 3JC66 5IY0A 4YWKA 4YWMA
chains in the Genus database with same CATH topology
4POFA 3F8TA 3JC62 3JC63 4YWLA 4POGA 2VL6A 4ME3A 1LTLA 3JC66 5IY0A 4YWKA 4YWMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4POF A;  3JC6 3;  3JC6 2;  4YWL A;  4POG A;  2VL6 A;  4ME3 A;  1LTL A;  3JC6 6;  5IY0 A;  4YWK A;  4YWM A; 
#chains in the Genus database with same CATH topology
 4POF A;  3F8T A;  3JC6 2;  3JC6 3;  4YWL A;  4POG A;  2VL6 A;  4ME3 A;  1LTL A;  3JC6 6;  5IY0 A;  4YWK A;  4YWM A; 
#chains in the Genus database with same CATH homology
 4POF A;  3F8T A;  3JC6 2;  3JC6 3;  4YWL A;  4POG A;  2VL6 A;  4ME3 A;  1LTL A;  3JC6 6;  5IY0 A;  4YWK A;  4YWM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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