3JC62

Structure of the eukaryotic replicative cmg helicase and pumpjack motion
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
260
structure length
241
Chain Sequence
PNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSESLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDFPTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLLGPFFQDSNEEIRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKPGEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRRE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Replication
molecule keywords DNA replication licensing factor MCM2
publication title Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
pubmed doi rcsb
source organism Saccharomyces cerevisiae
total genus 34
structure length 241
sequence length 260
ec nomenclature ec 3.6.4.12: DNA helicase.
pdb deposition date 2015-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
2 PF00493 MCM MCM P-loop domain
2 PF12619 MCM2_N Mini-chromosome maintenance protein 2
2 PF14551 MCM_N MCM N-terminal domain
2 PF17207 MCM_OB MCM OB domain
2 PF17855 MCM_lid MCM AAA-lid domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1640.10 Alpha Beta 2-Layer Sandwich mini-chromosome maintenance (MCM) complex, chain A, domain 1 mini-chromosome maintenance (MCM) complex, chain A, domain 1 3jc6201
2VL6A 4YWKA 1LTLA 5IY0A 3JC63 4ME3A 4POFA 4POGA 4YWMA 3JC62 4YWLA 3JC66
chains in the Genus database with same CATH superfamily
2VL6A 4YWKA 1LTLA 5IY0A 3JC63 4ME3A 4POFA 3F8TA 4POGA 4YWMA 3JC62 4YWLA 3JC66
chains in the Genus database with same CATH topology
2VL6A 4YWKA 1LTLA 5IY0A 3JC63 4ME3A 4POFA 3F8TA 4POGA 4YWMA 3JC62 4YWLA 3JC66
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VL6 A;  4YWK A;  1LTL A;  5IY0 A;  3JC6 3;  4ME3 A;  4POF A;  4POG A;  4YWM A;  3JC6 2;  4YWL A;  3JC6 6; 
#chains in the Genus database with same CATH topology
 2VL6 A;  4YWK A;  1LTL A;  5IY0 A;  3JC6 3;  4ME3 A;  4POF A;  3F8T A;  4POG A;  4YWM A;  3JC6 2;  4YWL A;  3JC6 6; 
#chains in the Genus database with same CATH homology
 2VL6 A;  4YWK A;  1LTL A;  5IY0 A;  3JC6 3;  4ME3 A;  4POF A;  3F8T A;  4POG A;  4YWM A;  3JC6 2;  4YWL A;  3JC6 6; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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