3K74A

Disruption of protein dynamics by an allosteric effector antibody
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
159
structure length
159
Chain Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Dihydrofolate reductase
publication title Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition.
pubmed doi rcsb
source organism Escherichia coli k-12
total genus 43
structure length 159
sequence length 159
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2009-10-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3k74A00
2W3VA 3FQOA 3FRDX 1TDRA 4PSTA 3OAFA 4H98A 4DP3A 5JG0X 1MVTA 4KBNA 3NXXA 1J3KA 6DFRA 1DAJA 3F0VX 3EEJA 3EEKA 1PD8A 2W3MA 2DHFA 2C2SA 2D0KA 2W3BA 3NXRA 1AO8A 1RX4A 2CD2A 3I3RA 1DLSA 3JSUA 3CL9A 1DRHA 2FZIA 1DR7A 1BOZA 2HQPA 3JWFA 3S3VA 4KY8A 3JW3A 3TQAA 1SEJA 3JWMA 3IA5A 4P66A 2B3ZA 4M7UA 5HSRA 4IXFX 1RG7A 1HFQA 3EIGA 3SRRX 1RA9A 1RX3A 4DFRA 2FZJA 4I1NA 3KGYA 4KJLA 4P3QA 8DFRA 4QJCA 3QL0A 2QK8A 3SRQX 2O7PA 5HVBA 3JW5A 1JOLA 5DFRA 3NXVA 4ELFA 4G95A 3FRAX 1RF7A 3NXTA 1IA4A 3EELA 4X5IA 3SGYA 4M2XA 3QG2A 3FREX 3ZPGA 4ELBA 4NX7A 4EJ1A 4QLGA 2ITHA 1RX7A 2L28A 3F0QX 3RO9A 2GD9A 3QLSA 3GI2A 3JVXA 1RE7A 3FQCA 3K45A 2HXVA 4ELEA 3SRSX 4KJJA 3FY9X 3K2HA 4H95A 2C2TA 3KFYA 4TU5X 5HVEA 4HOEA 1HFRA 1E26A 1AI9A 1DISA 2DRCA 1PDBA 4XE6X 1M79A 4LEKX 1DHIA 1RB3A 4FHBA 2P4GA 3ROAA 3TD8A 1QZFA 5HSUA 4M6KA 3GHWA 4PTJA 4G3MA 1DG7A 1KMSA 1S3VA 3UM6A 1RD7A 5HI6A 3FS6A 4LAHX 4KJKA 3SR5X 2LF1A 4ELHA 4P68A 1RB2A 3F8ZA 4M6JA 3JWKA 1U70A 3KJSA 3SA1A 3M08A 3IA4A 4KY4A 3NU0A 5HQZA 1VJ3A 3QLYA 4QI9A 1DYJA 3K74A 3FL8A 2INQA 3M09A 1LUDA 1DF7A 4X5JA 2XW7A 1J3IA 5JA3A 2OBCA 4XT5A 5HT4A 3F0BX 5HQYA 2HM9A 1RX5A 3HBBA 2ANQA 1DR4A 3NRRA 1S3WA 3FYWX 1PD9A 1RH3A 1BZFA 1DYIA 1JOMA 3LG4A 2G6VA 4KD7A 1KMVA 3D84X 1DR1A 1DREA 3FQFA 1U72A 4CD2A 2W9SA 5HPBA 1DG5A 4QHVA 3Q1HA 2BL9A 5ECXA 3QLZA 3R33A 1M78A 3F0UX 3FRFX 3NZCX 3UM8A 3S7AA 3SRWX 3FRBX 4Q67A 4PTHA 3NZDA 3CLBA 2KGKA 4DPHA 5HUIA 4ELGA 1DR3A 4PSYA 3HJ3A 1RA3A 4QLEA 1DHJA 2CIGA 1S3YA 3KY8A 3TQ9A 1YHOA 4KM2A 4Q0EA 4KNEA 4H97A 3IRMA 3F0XX 3E0BA 3D80A 1DYRA 3FY8X 4KLXA 1S3UA 3QLXA 1MVSA 1RX9A 1JUVA 1DRAA 2JYBA 4NX6A 4Q0DA 5HF2X 1J3JA 1IA2A 4LAGX 4Q6AA 3F8YA 4PSSA 4KFJA 3NZ6X 3FYVX 3DL5A 1OHKA 1CZ3A 1DYHA 3IROA 2BLCA 3DL6A 3L3RA 4M7VA 5CC9A 4P3RA 1KLKA 1RX8A 4FGHA 3GYFA 1DG8A 2W9TA 4M6LA 3SH2A 3FQZA 4FGGA 1DDRA 3EEMA 1AOEA 4PDJA 3NXOA 3TQBA 3DAUA 4EILA 3F91A 1RA2A 2OIPA 4IXED 3NZAX 4HOFA 4XT4A 1LY4A 4XRBA 2FZHA 3N0HA 3EX8A 3GHVA 4G8ZX 4EIZA 4KAKA 1M7AA 1DIUA 4GH8A 1RX2A 1DLRA 3KJRA 4OSGA 2BLBA 3CSEA 4XT8A 2ZZAA 3JTWA 4LAEX 3DG8A 1DRFA 5HT5A 3DRCA 1DHFA 4EIGA 1IA1A 3OCHA 5FDAA 3QGTA 4H96A 3VCOA 2W3WA 4QLFA 3DATA 5CCCA 5DXVA 4HA9A 3SA2A 3FQ0A 2D5NA 2W9HA 3QLWA 1IA3A 4DDRA 3NZ9X 4KEBA 3QYOA 4OR7A 2W3AA 3ZPCA 4KL9A 3CD2A 1DR2A 3FL9A 3DFRA 4KYAA 3K47A 1DR6A 3NTZA 1DR5A 3JWCA 3SAIA 4IXGX 3SRUX 1CD2A 1DRBA 1RA8A 4XECX 3IRNA 2H2QA 3QFXA 4DPDA 3GHCA 3I8AX 2AZNA 3NZBX 2BLAA 1RC4A 1DDSA 4XT7A 1RX1A 4KM0A 5U26A 1RA1A 2ANOA 3QLRA 3DGAA 1HFPA 3FQVA 3QL3A 4I13A 1ZDRA 4HA7A 4QJZD 4XT6A 1RX6A 3SQYX 5HF0X 1LY3A 5U27A 3TQ8A 3QYLA 4HOGA 4RGCA 1VDRA 3RG9A 4X5GA 2W9GA 4X5FA 3NXYA 5E8QA 4ECKA 5ECCA 1D1GA 3F0SX 5EAJA 3S9UA 1U71A 3INVA 3UM5A 7DFRA 4X5HA 3IX9A 1OHJA
chains in the Genus database with same CATH superfamily
2W3VA 3FQOA 3FRDX 1TDRA 4PSTA 3OAFA 4H98A 4DP3A 5JG0X 1MVTA 4KBNA 3NXXA 1J3KA 6DFRA 1DAJA 3F0VX 3EEJA 3EEKA 1PD8A 2W3MA 2DHFA 2C2SA 2D0KA 2W3BA 3NXRA 1AO8A 1RX4A 2CD2A 3I3RA 1DLSA 3JSUA 3CL9A 1DRHA 2FZIA 1DR7A 1BOZA 2HQPA 3JWFA 3S3VA 4KY8A 3JW3A 3TQAA 1SEJA 3JWMA 3IA5A 4P66A 2B3ZA 4M7UA 5HSRA 4IXFX 1RG7A 1HFQA 3EIGA 3SRRX 1RA9A 1RX3A 4DFRA 2FZJA 4I1NA 3KGYA 4KJLA 4P3QA 8DFRA 4QJCA 3QL0A 2QK8A 3SRQX 2O7PA 5HVBA 3JW5A 1JOLA 5DFRA 3NXVA 4ELFA 4G95A 3FRAX 1RF7A 3NXTA 1IA4A 3EELA 4X5IA 3SGYA 4M2XA 3QG2A 3FREX 3ZPGA 4ELBA 4NX7A 4EJ1A 4QLGA 2ITHA 1RX7A 2L28A 3F0QX 3RO9A 2GD9A 3QLSA 3GI2A 3JVXA 1RE7A 3FQCA 3K45A 2HXVA 4ELEA 3SRSX 4KJJA 3FY9X 3K2HA 4H95A 2C2TA 3KFYA 4TU5X 5HVEA 4HOEA 1HFRA 1E26A 1AI9A 1DISA 2DRCA 1PDBA 4XE6X 1M79A 4LEKX 1DHIA 1RB3A 4FHBA 2P4GA 3ROAA 3TD8A 1QZFA 5HSUA 4M6KA 3GHWA 4PTJA 4G3MA 1DG7A 1KMSA 1S3VA 3UM6A 1RD7A 5HI6A 3FS6A 4LAHX 4KJKA 3SR5X 2LF1A 4ELHA 4P68A 1RB2A 3F8ZA 4M6JA 3JWKA 1U70A 3KJSA 3SA1A 3M08A 3IA4A 4KY4A 3NU0A 5HQZA 1VJ3A 3QLYA 4QI9A 1DYJA 3K74A 3FL8A 2INQA 3M09A 1LUDA 1DF7A 4X5JA 2XW7A 1J3IA 5JA3A 2OBCA 4XT5A 5HT4A 3F0BX 5HQYA 2HM9A 1RX5A 3HBBA 2ANQA 1DR4A 3NRRA 1S3WA 3FYWX 1PD9A 1RH3A 1BZFA 1DYIA 1JOMA 3LG4A 2G6VA 4KD7A 1KMVA 3D84X 1DR1A 1DREA 3FQFA 1U72A 4CD2A 2W9SA 5HPBA 1DG5A 4QHVA 3Q1HA 2BL9A 5ECXA 3QLZA 3R33A 1M78A 3F0UX 3FRFX 3NZCX 3UM8A 3S7AA 3SRWX 3FRBX 4Q67A 4PTHA 3NZDA 3CLBA 2KGKA 4DPHA 5HUIA 4ELGA 1DR3A 4PSYA 3HJ3A 1RA3A 4QLEA 1DHJA 2CIGA 1S3YA 3KY8A 3TQ9A 1YHOA 4KM2A 4Q0EA 4KNEA 4H97A 3IRMA 3F0XX 3E0BA 3D80A 1DYRA 3FY8X 4KLXA 1S3UA 3QLXA 1MVSA 1RX9A 1JUVA 1DRAA 2JYBA 4NX6A 4Q0DA 5HF2X 1J3JA 1IA2A 4LAGX 4Q6AA 3F8YA 4PSSA 4KFJA 3NZ6X 3FYVX 3DL5A 1OHKA 1CZ3A 1DYHA 3IROA 2BLCA 3DL6A 3L3RA 4M7VA 5CC9A 4P3RA 1KLKA 1RX8A 4FGHA 3GYFA 1DG8A 2W9TA 4M6LA 3SH2A 3FQZA 4FGGA 1DDRA 3EEMA 1AOEA 4PDJA 3NXOA 3TQBA 3DAUA 4EILA 3F91A 1RA2A 2OIPA 4IXED 3NZAX 4HOFA 4XT4A 1LY4A 4XRBA 2FZHA 3N0HA 3EX8A 3GHVA 4G8ZX 4EIZA 4KAKA 1M7AA 1DIUA 4GH8A 1RX2A 1DLRA 3KJRA 4OSGA 2BLBA 3CSEA 4XT8A 2ZZAA 3JTWA 4LAEX 3DG8A 1DRFA 5HT5A 3DRCA 1DHFA 4EIGA 1IA1A 3OCHA 5FDAA 3QGTA 4H96A 3VCOA 2W3WA 4QLFA 3DATA 5CCCA 5DXVA 4HA9A 3SA2A 3FQ0A 2D5NA 2W9HA 3QLWA 1IA3A 4DDRA 3NZ9X 4KEBA 3QYOA 4OR7A 2W3AA 3ZPCA 4KL9A 3CD2A 1DR2A 3FL9A 3DFRA 4KYAA 3K47A 1DR6A 3NTZA 1DR5A 3JWCA 3SAIA 4IXGX 3SRUX 1CD2A 1DRBA 1RA8A 4XECX 3IRNA 2H2QA 3QFXA 4DPDA 3GHCA 3I8AX 2AZNA 3NZBX 2BLAA 1RC4A 1DDSA 4XT7A 1RX1A 4KM0A 5U26A 1RA1A 2ANOA 3QLRA 3DGAA 1HFPA 3FQVA 3QL3A 4I13A 1ZDRA 4HA7A 4QJZD 4XT6A 1RX6A 3SQYX 5HF0X 1LY3A 5U27A 3TQ8A 3QYLA 4HOGA 4RGCA 1VDRA 3RG9A 4X5GA 2W9GA 4X5FA 3NXYA 5E8QA 4ECKA 5ECCA 1D1GA 3F0SX 5EAJA 3S9UA 1U71A 3INVA 3UM5A 7DFRA 4X5HA 3IX9A 1OHJA
chains in the Genus database with same CATH topology
2W3VA 3FQOA 3FRDX 1TDRA 4PSTA 3OAFA 4H98A 4DP3A 5JG0X 1MVTA 4KBNA 3NXXA 1J3KA 6DFRA 1DAJA 3F0VX 3EEJA 3EEKA 1PD8A 2W3MA 2DHFA 2C2SA 2D0KA 2W3BA 3NXRA 1AO8A 1RX4A 2CD2A 3I3RA 1DLSA 3JSUA 3CL9A 1DRHA 2FZIA 1DR7A 1BOZA 2HQPA 3JWFA 3S3VA 4KY8A 3JW3A 3TQAA 1SEJA 3JWMA 3IA5A 4P66A 2B3ZA 4M7UA 5HSRA 4IXFX 1RG7A 1HFQA 3EIGA 3SRRX 1RA9A 1RX3A 4DFRA 2FZJA 4I1NA 3KGYA 4KJLA 4P3QA 8DFRA 4QJCA 3QL0A 2QK8A 3SRQX 2O7PA 5HVBA 3JW5A 1JOLA 5DFRA 3NXVA 4ELFA 4G95A 3FRAX 1RF7A 3NXTA 1IA4A 3EELA 4X5IA 3SGYA 4M2XA 3QG2A 3FREX 3ZPGA 4ELBA 4NX7A 4EJ1A 4QLGA 2ITHA 1RX7A 2L28A 3F0QX 3RO9A 2GD9A 3QLSA 3GI2A 3JVXA 1RE7A 3FQCA 3K45A 2HXVA 4ELEA 3SRSX 4KJJA 3FY9X 3K2HA 4H95A 2C2TA 3KFYA 4TU5X 5HVEA 4HOEA 1HFRA 1E26A 1AI9A 1DISA 2DRCA 1PDBA 4XE6X 1M79A 4LEKX 1DHIA 1RB3A 4FHBA 2P4GA 3ROAA 3TD8A 1QZFA 5HSUA 4M6KA 3GHWA 4PTJA 4G3MA 1DG7A 1KMSA 1S3VA 3UM6A 1RD7A 5HI6A 3FS6A 4LAHX 4KJKA 3SR5X 2LF1A 4ELHA 4P68A 1RB2A 3F8ZA 4M6JA 3JWKA 1U70A 3KJSA 3SA1A 3M08A 3IA4A 4KY4A 3NU0A 5HQZA 1VJ3A 3QLYA 4QI9A 1DYJA 3K74A 3FL8A 2INQA 3M09A 1LUDA 1DF7A 4X5JA 2XW7A 1J3IA 5JA3A 2OBCA 4XT5A 5HT4A 3F0BX 5HQYA 2HM9A 1RX5A 3HBBA 2ANQA 1DR4A 3NRRA 1S3WA 3FYWX 1PD9A 1RH3A 1BZFA 1DYIA 1JOMA 3LG4A 2G6VA 4KD7A 1KMVA 3D84X 1DR1A 1DREA 3FQFA 1U72A 4CD2A 2W9SA 5HPBA 1DG5A 4QHVA 3Q1HA 2BL9A 5ECXA 3QLZA 3R33A 1M78A 3F0UX 3FRFX 3NZCX 3UM8A 3S7AA 3SRWX 3FRBX 4Q67A 4PTHA 3NZDA 3CLBA 2KGKA 4DPHA 5HUIA 4ELGA 1DR3A 4PSYA 3HJ3A 1RA3A 4QLEA 1DHJA 2CIGA 1S3YA 3KY8A 3TQ9A 1YHOA 4KM2A 4Q0EA 4KNEA 4H97A 3IRMA 3F0XX 3E0BA 3D80A 1DYRA 3FY8X 4KLXA 1S3UA 3QLXA 1MVSA 1RX9A 1JUVA 1DRAA 2JYBA 4NX6A 4Q0DA 5HF2X 1J3JA 1IA2A 4LAGX 4Q6AA 3F8YA 4PSSA 4KFJA 3NZ6X 3FYVX 3DL5A 1OHKA 1CZ3A 1DYHA 3IROA 2BLCA 3DL6A 3L3RA 4M7VA 5CC9A 4P3RA 1KLKA 1RX8A 4FGHA 3GYFA 1DG8A 2W9TA 4M6LA 3SH2A 3FQZA 4FGGA 1DDRA 3EEMA 1AOEA 4PDJA 3NXOA 3TQBA 3DAUA 4EILA 3F91A 1RA2A 2OIPA 4IXED 3NZAX 4HOFA 4XT4A 1LY4A 4XRBA 2FZHA 3N0HA 3EX8A 3GHVA 4G8ZX 4EIZA 4KAKA 1M7AA 1DIUA 4GH8A 1RX2A 1DLRA 3KJRA 4OSGA 2BLBA 3CSEA 4XT8A 2ZZAA 3JTWA 4LAEX 3DG8A 1DRFA 5HT5A 3DRCA 1DHFA 4EIGA 1IA1A 3OCHA 5FDAA 3QGTA 4H96A 3VCOA 2W3WA 4QLFA 3DATA 5CCCA 5DXVA 4HA9A 3SA2A 3FQ0A 2D5NA 2W9HA 3QLWA 1IA3A 4DDRA 3NZ9X 4KEBA 3QYOA 4OR7A 2W3AA 3ZPCA 4KL9A 3CD2A 1DR2A 3FL9A 3DFRA 4KYAA 3K47A 1DR6A 3NTZA 1DR5A 3JWCA 3SAIA 4IXGX 3SRUX 1CD2A 1DRBA 1RA8A 4XECX 3IRNA 2H2QA 3QFXA 4DPDA 3GHCA 3I8AX 2AZNA 3NZBX 2BLAA 1RC4A 1DDSA 4XT7A 1RX1A 4KM0A 5U26A 1RA1A 2ANOA 3QLRA 3DGAA 1HFPA 3FQVA 3QL3A 4I13A 1ZDRA 4HA7A 4QJZD 4XT6A 1RX6A 3SQYX 5HF0X 1LY3A 5U27A 3TQ8A 3QYLA 4HOGA 4RGCA 1VDRA 3RG9A 4X5GA 2W9GA 4X5FA 3NXYA 5E8QA 4ECKA 5ECCA 1D1GA 3F0SX 5EAJA 3S9UA 1U71A 3INVA 3UM5A 7DFRA 4X5HA 3IX9A 1OHJA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2W3V A;  3FQO A;  3FRD X;  1TDR A;  4PST A;  3OAF A;  4H98 A;  4DP3 A;  5JG0 X;  1MVT A;  4KBN A;  3NXX A;  1J3K A;  6DFR A;  1DAJ A;  3F0V X;  3EEJ A;  3EEK A;  1PD8 A;  2W3M A;  2DHF A;  2C2S A;  2D0K A;  2W3B A;  3NXR A;  1AO8 A;  1RX4 A;  2CD2 A;  3I3R A;  1DLS A;  3JSU A;  3CL9 A;  1DRH A;  2FZI A;  1DR7 A;  1BOZ A;  2HQP A;  3JWF A;  3S3V A;  4KY8 A;  3JW3 A;  3TQA A;  1SEJ A;  3JWM A;  3IA5 A;  4P66 A;  2B3Z A;  4M7U A;  5HSR A;  4IXF X;  1RG7 A;  1HFQ A;  3EIG A;  3SRR X;  1RA9 A;  1RX3 A;  4DFR A;  2FZJ A;  4I1N A;  3KGY A;  4KJL A;  4P3Q A;  8DFR A;  4QJC A;  3QL0 A;  2QK8 A;  3SRQ X;  2O7P A;  5HVB A;  3JW5 A;  1JOL A;  5DFR A;  3NXV A;  4ELF A;  4G95 A;  3FRA X;  1RF7 A;  3NXT A;  1IA4 A;  3EEL A;  4X5I A;  3SGY A;  4M2X A;  3QG2 A;  3FRE X;  3ZPG A;  4ELB A;  4NX7 A;  4EJ1 A;  4QLG A;  2ITH A;  1RX7 A;  2L28 A;  3F0Q X;  3RO9 A;  2GD9 A;  3QLS A;  3GI2 A;  3JVX A;  1RE7 A;  3FQC A;  3K45 A;  2HXV A;  4ELE A;  3SRS X;  4KJJ A;  3FY9 X;  3K2H A;  4H95 A;  2C2T A;  3KFY A;  4TU5 X;  5HVE A;  4HOE A;  1HFR A;  1E26 A;  1AI9 A;  1DIS A;  2DRC A;  1PDB A;  4XE6 X;  1M79 A;  4LEK X;  1DHI A;  1RB3 A;  4FHB A;  2P4G A;  3ROA A;  3TD8 A;  1QZF A;  5HSU A;  4M6K A;  3GHW A;  4PTJ A;  4G3M A;  1DG7 A;  1KMS A;  1S3V A;  3UM6 A;  1RD7 A;  5HI6 A;  3FS6 A;  4LAH X;  4KJK A;  3SR5 X;  2LF1 A;  4ELH A;  4P68 A;  1RB2 A;  3F8Z A;  4M6J A;  3JWK A;  1U70 A;  3KJS A;  3SA1 A;  3M08 A;  3IA4 A;  4KY4 A;  3NU0 A;  5HQZ A;  1VJ3 A;  3QLY A;  4QI9 A;  1DYJ A;  3K74 A;  3FL8 A;  2INQ A;  3M09 A;  1LUD A;  1DF7 A;  4X5J A;  2XW7 A;  1J3I A;  5JA3 A;  2OBC A;  4XT5 A;  5HT4 A;  3F0B X;  5HQY A;  2HM9 A;  1RX5 A;  3HBB A;  2ANQ A;  1DR4 A;  3NRR A;  1S3W A;  3FYW X;  1PD9 A;  1RH3 A;  1BZF A;  1DYI A;  1JOM A;  3LG4 A;  2G6V A;  4KD7 A;  1KMV A;  3D84 X;  1DR1 A;  1DRE A;  3FQF A;  1U72 A;  4CD2 A;  2W9S A;  5HPB A;  1DG5 A;  4QHV A;  3Q1H A;  2BL9 A;  5ECX A;  3QLZ A;  3R33 A;  1M78 A;  3F0U X;  3FRF X;  3NZC X;  3UM8 A;  3S7A A;  3SRW X;  3FRB X;  4Q67 A;  4PTH A;  3NZD A;  3CLB A;  2KGK A;  4DPH A;  5HUI A;  4ELG A;  1DR3 A;  4PSY A;  3HJ3 A;  1RA3 A;  4QLE A;  1DHJ A;  2CIG A;  1S3Y A;  3KY8 A;  3TQ9 A;  1YHO A;  4KM2 A;  4Q0E A;  4KNE A;  4H97 A;  3IRM A;  3F0X X;  3E0B A;  3D80 A;  1DYR A;  3FY8 X;  4KLX A;  1S3U A;  3QLX A;  1MVS A;  1RX9 A;  1JUV A;  1DRA A;  2JYB A;  4NX6 A;  4Q0D A;  5HF2 X;  1J3J A;  1IA2 A;  4LAG X;  4Q6A A;  3F8Y A;  4PSS A;  4KFJ A;  3NZ6 X;  3FYV X;  3DL5 A;  1OHK A;  1CZ3 A;  1DYH A;  3IRO A;  2BLC A;  3DL6 A;  3L3R A;  4M7V A;  5CC9 A;  4P3R A;  1KLK A;  1RX8 A;  4FGH A;  3GYF A;  1DG8 A;  2W9T A;  4M6L A;  3SH2 A;  3FQZ A;  4FGG A;  1DDR A;  3EEM A;  1AOE A;  4PDJ A;  3NXO A;  3TQB A;  3DAU A;  4EIL A;  3F91 A;  1RA2 A;  2OIP A;  4IXE D;  3NZA X;  4HOF A;  4XT4 A;  1LY4 A;  4XRB A;  2FZH A;  3N0H A;  3EX8 A;  3GHV A;  4G8Z X;  4EIZ A;  4KAK A;  1M7A A;  1DIU A;  4GH8 A;  1RX2 A;  1DLR A;  3KJR A;  4OSG A;  2BLB A;  3CSE A;  4XT8 A;  2ZZA A;  3JTW A;  4LAE X;  3DG8 A;  1DRF A;  5HT5 A;  3DRC A;  1DHF A;  4EIG A;  1IA1 A;  3OCH A;  5FDA A;  3QGT A;  4H96 A;  3VCO A;  2W3W A;  4QLF A;  3DAT A;  5CCC A;  5DXV A;  4HA9 A;  3SA2 A;  3FQ0 A;  2D5N A;  2W9H A;  3QLW A;  1IA3 A;  4DDR A;  3NZ9 X;  4KEB A;  3QYO A;  4OR7 A;  2W3A A;  3ZPC A;  4KL9 A;  3CD2 A;  1DR2 A;  3FL9 A;  3DFR A;  4KYA A;  3K47 A;  1DR6 A;  3NTZ A;  1DR5 A;  3JWC A;  3SAI A;  4IXG X;  3SRU X;  1CD2 A;  1DRB A;  1RA8 A;  4XEC X;  3IRN A;  2H2Q A;  3QFX A;  4DPD A;  3GHC A;  3I8A X;  2AZN A;  3NZB X;  2BLA A;  1RC4 A;  1DDS A;  4XT7 A;  1RX1 A;  4KM0 A;  5U26 A;  1RA1 A;  2ANO A;  3QLR A;  3DGA A;  1HFP A;  3FQV A;  3QL3 A;  4I13 A;  1ZDR A;  4HA7 A;  4QJZ D;  4XT6 A;  1RX6 A;  3SQY X;  5HF0 X;  1LY3 A;  5U27 A;  3TQ8 A;  3QYL A;  4HOG A;  4RGC A;  1VDR A;  3RG9 A;  4X5G A;  2W9G A;  4X5F A;  3NXY A;  5E8Q A;  4ECK A;  5ECC A;  1D1G A;  3F0S X;  5EAJ A;  3S9U A;  1U71 A;  3INV A;  3UM5 A;  7DFR A;  4X5H A;  3IX9 A;  1OHJ A; 
#chains in the Genus database with same CATH topology
 2W3V A;  3FQO A;  3FRD X;  1TDR A;  4PST A;  3OAF A;  4H98 A;  4DP3 A;  5JG0 X;  1MVT A;  4KBN A;  3NXX A;  1J3K A;  6DFR A;  1DAJ A;  3F0V X;  3EEJ A;  3EEK A;  1PD8 A;  2W3M A;  2DHF A;  2C2S A;  2D0K A;  2W3B A;  3NXR A;  1AO8 A;  1RX4 A;  2CD2 A;  3I3R A;  1DLS A;  3JSU A;  3CL9 A;  1DRH A;  2FZI A;  1DR7 A;  1BOZ A;  2HQP A;  3JWF A;  3S3V A;  4KY8 A;  3JW3 A;  3TQA A;  1SEJ A;  3JWM A;  3IA5 A;  4P66 A;  2B3Z A;  4M7U A;  5HSR A;  4IXF X;  1RG7 A;  1HFQ A;  3EIG A;  3SRR X;  1RA9 A;  1RX3 A;  4DFR A;  2FZJ A;  4I1N A;  3KGY A;  4KJL A;  4P3Q A;  8DFR A;  4QJC A;  3QL0 A;  2QK8 A;  3SRQ X;  2O7P A;  5HVB A;  3JW5 A;  1JOL A;  5DFR A;  3NXV A;  4ELF A;  4G95 A;  3FRA X;  1RF7 A;  3NXT A;  1IA4 A;  3EEL A;  4X5I A;  3SGY A;  4M2X A;  3QG2 A;  3FRE X;  3ZPG A;  4ELB A;  4NX7 A;  4EJ1 A;  4QLG A;  2ITH A;  1RX7 A;  2L28 A;  3F0Q X;  3RO9 A;  2GD9 A;  3QLS A;  3GI2 A;  3JVX A;  1RE7 A;  3FQC A;  3K45 A;  2HXV A;  4ELE A;  3SRS X;  4KJJ A;  3FY9 X;  3K2H A;  4H95 A;  2C2T A;  3KFY A;  4TU5 X;  5HVE A;  4HOE A;  1HFR A;  1E26 A;  1AI9 A;  1DIS A;  2DRC A;  1PDB A;  4XE6 X;  1M79 A;  4LEK X;  1DHI A;  1RB3 A;  4FHB A;  2P4G A;  3ROA A;  3TD8 A;  1QZF A;  5HSU A;  4M6K A;  3GHW A;  4PTJ A;  4G3M A;  1DG7 A;  1KMS A;  1S3V A;  3UM6 A;  1RD7 A;  5HI6 A;  3FS6 A;  4LAH X;  4KJK A;  3SR5 X;  2LF1 A;  4ELH A;  4P68 A;  1RB2 A;  3F8Z A;  4M6J A;  3JWK A;  1U70 A;  3KJS A;  3SA1 A;  3M08 A;  3IA4 A;  4KY4 A;  3NU0 A;  5HQZ A;  1VJ3 A;  3QLY A;  4QI9 A;  1DYJ A;  3K74 A;  3FL8 A;  2INQ A;  3M09 A;  1LUD A;  1DF7 A;  4X5J A;  2XW7 A;  1J3I A;  5JA3 A;  2OBC A;  4XT5 A;  5HT4 A;  3F0B X;  5HQY A;  2HM9 A;  1RX5 A;  3HBB A;  2ANQ A;  1DR4 A;  3NRR A;  1S3W A;  3FYW X;  1PD9 A;  1RH3 A;  1BZF A;  1DYI A;  1JOM A;  3LG4 A;  2G6V A;  4KD7 A;  1KMV A;  3D84 X;  1DR1 A;  1DRE A;  3FQF A;  1U72 A;  4CD2 A;  2W9S A;  5HPB A;  1DG5 A;  4QHV A;  3Q1H A;  2BL9 A;  5ECX A;  3QLZ A;  3R33 A;  1M78 A;  3F0U X;  3FRF X;  3NZC X;  3UM8 A;  3S7A A;  3SRW X;  3FRB X;  4Q67 A;  4PTH A;  3NZD A;  3CLB A;  2KGK A;  4DPH A;  5HUI A;  4ELG A;  1DR3 A;  4PSY A;  3HJ3 A;  1RA3 A;  4QLE A;  1DHJ A;  2CIG A;  1S3Y A;  3KY8 A;  3TQ9 A;  1YHO A;  4KM2 A;  4Q0E A;  4KNE A;  4H97 A;  3IRM A;  3F0X X;  3E0B A;  3D80 A;  1DYR A;  3FY8 X;  4KLX A;  1S3U A;  3QLX A;  1MVS A;  1RX9 A;  1JUV A;  1DRA A;  2JYB A;  4NX6 A;  4Q0D A;  5HF2 X;  1J3J A;  1IA2 A;  4LAG X;  4Q6A A;  3F8Y A;  4PSS A;  4KFJ A;  3NZ6 X;  3FYV X;  3DL5 A;  1OHK A;  1CZ3 A;  1DYH A;  3IRO A;  2BLC A;  3DL6 A;  3L3R A;  4M7V A;  5CC9 A;  4P3R A;  1KLK A;  1RX8 A;  4FGH A;  3GYF A;  1DG8 A;  2W9T A;  4M6L A;  3SH2 A;  3FQZ A;  4FGG A;  1DDR A;  3EEM A;  1AOE A;  4PDJ A;  3NXO A;  3TQB A;  3DAU A;  4EIL A;  3F91 A;  1RA2 A;  2OIP A;  4IXE D;  3NZA X;  4HOF A;  4XT4 A;  1LY4 A;  4XRB A;  2FZH A;  3N0H A;  3EX8 A;  3GHV A;  4G8Z X;  4EIZ A;  4KAK A;  1M7A A;  1DIU A;  4GH8 A;  1RX2 A;  1DLR A;  3KJR A;  4OSG A;  2BLB A;  3CSE A;  4XT8 A;  2ZZA A;  3JTW A;  4LAE X;  3DG8 A;  1DRF A;  5HT5 A;  3DRC A;  1DHF A;  4EIG A;  1IA1 A;  3OCH A;  5FDA A;  3QGT A;  4H96 A;  3VCO A;  2W3W A;  4QLF A;  3DAT A;  5CCC A;  5DXV A;  4HA9 A;  3SA2 A;  3FQ0 A;  2D5N A;  2W9H A;  3QLW A;  1IA3 A;  4DDR A;  3NZ9 X;  4KEB A;  3QYO A;  4OR7 A;  2W3A A;  3ZPC A;  4KL9 A;  3CD2 A;  1DR2 A;  3FL9 A;  3DFR A;  4KYA A;  3K47 A;  1DR6 A;  3NTZ A;  1DR5 A;  3JWC A;  3SAI A;  4IXG X;  3SRU X;  1CD2 A;  1DRB A;  1RA8 A;  4XEC X;  3IRN A;  2H2Q A;  3QFX A;  4DPD A;  3GHC A;  3I8A X;  2AZN A;  3NZB X;  2BLA A;  1RC4 A;  1DDS A;  4XT7 A;  1RX1 A;  4KM0 A;  5U26 A;  1RA1 A;  2ANO A;  3QLR A;  3DGA A;  1HFP A;  3FQV A;  3QL3 A;  4I13 A;  1ZDR A;  4HA7 A;  4QJZ D;  4XT6 A;  1RX6 A;  3SQY X;  5HF0 X;  1LY3 A;  5U27 A;  3TQ8 A;  3QYL A;  4HOG A;  4RGC A;  1VDR A;  3RG9 A;  4X5G A;  2W9G A;  4X5F A;  3NXY A;  5E8Q A;  4ECK A;  5ECC A;  1D1G A;  3F0S X;  5EAJ A;  3S9U A;  1U71 A;  3INV A;  3UM5 A;  7DFR A;  4X5H A;  3IX9 A;  1OHJ A; 
#chains in the Genus database with same CATH homology
 2W3V A;  3FQO A;  3FRD X;  1TDR A;  4PST A;  3OAF A;  4H98 A;  4DP3 A;  5JG0 X;  1MVT A;  4KBN A;  3NXX A;  1J3K A;  6DFR A;  1DAJ A;  3F0V X;  3EEJ A;  3EEK A;  1PD8 A;  2W3M A;  2DHF A;  2C2S A;  2D0K A;  2W3B A;  3NXR A;  1AO8 A;  1RX4 A;  2CD2 A;  3I3R A;  1DLS A;  3JSU A;  3CL9 A;  1DRH A;  2FZI A;  1DR7 A;  1BOZ A;  2HQP A;  3JWF A;  3S3V A;  4KY8 A;  3JW3 A;  3TQA A;  1SEJ A;  3JWM A;  3IA5 A;  4P66 A;  2B3Z A;  4M7U A;  5HSR A;  4IXF X;  1RG7 A;  1HFQ A;  3EIG A;  3SRR X;  1RA9 A;  1RX3 A;  4DFR A;  2FZJ A;  4I1N A;  3KGY A;  4KJL A;  4P3Q A;  8DFR A;  4QJC A;  3QL0 A;  2QK8 A;  3SRQ X;  2O7P A;  5HVB A;  3JW5 A;  1JOL A;  5DFR A;  3NXV A;  4ELF A;  4G95 A;  3FRA X;  1RF7 A;  3NXT A;  1IA4 A;  3EEL A;  4X5I A;  3SGY A;  4M2X A;  3QG2 A;  3FRE X;  3ZPG A;  4ELB A;  4NX7 A;  4EJ1 A;  4QLG A;  2ITH A;  1RX7 A;  2L28 A;  3F0Q X;  3RO9 A;  2GD9 A;  3QLS A;  3GI2 A;  3JVX A;  1RE7 A;  3FQC A;  3K45 A;  2HXV A;  4ELE A;  3SRS X;  4KJJ A;  3FY9 X;  3K2H A;  4H95 A;  2C2T A;  3KFY A;  4TU5 X;  5HVE A;  4HOE A;  1HFR A;  1E26 A;  1AI9 A;  1DIS A;  2DRC A;  1PDB A;  4XE6 X;  1M79 A;  4LEK X;  1DHI A;  1RB3 A;  4FHB A;  2P4G A;  3ROA A;  3TD8 A;  1QZF A;  5HSU A;  4M6K A;  3GHW A;  4PTJ A;  4G3M A;  1DG7 A;  1KMS A;  1S3V A;  3UM6 A;  1RD7 A;  5HI6 A;  3FS6 A;  4LAH X;  4KJK A;  3SR5 X;  2LF1 A;  4ELH A;  4P68 A;  1RB2 A;  3F8Z A;  4M6J A;  3JWK A;  1U70 A;  3KJS A;  3SA1 A;  3M08 A;  3IA4 A;  4KY4 A;  3NU0 A;  5HQZ A;  1VJ3 A;  3QLY A;  4QI9 A;  1DYJ A;  3K74 A;  3FL8 A;  2INQ A;  3M09 A;  1LUD A;  1DF7 A;  4X5J A;  2XW7 A;  1J3I A;  5JA3 A;  2OBC A;  4XT5 A;  5HT4 A;  3F0B X;  5HQY A;  2HM9 A;  1RX5 A;  3HBB A;  2ANQ A;  1DR4 A;  3NRR A;  1S3W A;  3FYW X;  1PD9 A;  1RH3 A;  1BZF A;  1DYI A;  1JOM A;  3LG4 A;  2G6V A;  4KD7 A;  1KMV A;  3D84 X;  1DR1 A;  1DRE A;  3FQF A;  1U72 A;  4CD2 A;  2W9S A;  5HPB A;  1DG5 A;  4QHV A;  3Q1H A;  2BL9 A;  5ECX A;  3QLZ A;  3R33 A;  1M78 A;  3F0U X;  3FRF X;  3NZC X;  3UM8 A;  3S7A A;  3SRW X;  3FRB X;  4Q67 A;  4PTH A;  3NZD A;  3CLB A;  2KGK A;  4DPH A;  5HUI A;  4ELG A;  1DR3 A;  4PSY A;  3HJ3 A;  1RA3 A;  4QLE A;  1DHJ A;  2CIG A;  1S3Y A;  3KY8 A;  3TQ9 A;  1YHO A;  4KM2 A;  4Q0E A;  4KNE A;  4H97 A;  3IRM A;  3F0X X;  3E0B A;  3D80 A;  1DYR A;  3FY8 X;  4KLX A;  1S3U A;  3QLX A;  1MVS A;  1RX9 A;  1JUV A;  1DRA A;  2JYB A;  4NX6 A;  4Q0D A;  5HF2 X;  1J3J A;  1IA2 A;  4LAG X;  4Q6A A;  3F8Y A;  4PSS A;  4KFJ A;  3NZ6 X;  3FYV X;  3DL5 A;  1OHK A;  1CZ3 A;  1DYH A;  3IRO A;  2BLC A;  3DL6 A;  3L3R A;  4M7V A;  5CC9 A;  4P3R A;  1KLK A;  1RX8 A;  4FGH A;  3GYF A;  1DG8 A;  2W9T A;  4M6L A;  3SH2 A;  3FQZ A;  4FGG A;  1DDR A;  3EEM A;  1AOE A;  4PDJ A;  3NXO A;  3TQB A;  3DAU A;  4EIL A;  3F91 A;  1RA2 A;  2OIP A;  4IXE D;  3NZA X;  4HOF A;  4XT4 A;  1LY4 A;  4XRB A;  2FZH A;  3N0H A;  3EX8 A;  3GHV A;  4G8Z X;  4EIZ A;  4KAK A;  1M7A A;  1DIU A;  4GH8 A;  1RX2 A;  1DLR A;  3KJR A;  4OSG A;  2BLB A;  3CSE A;  4XT8 A;  2ZZA A;  3JTW A;  4LAE X;  3DG8 A;  1DRF A;  5HT5 A;  3DRC A;  1DHF A;  4EIG A;  1IA1 A;  3OCH A;  5FDA A;  3QGT A;  4H96 A;  3VCO A;  2W3W A;  4QLF A;  3DAT A;  5CCC A;  5DXV A;  4HA9 A;  3SA2 A;  3FQ0 A;  2D5N A;  2W9H A;  3QLW A;  1IA3 A;  4DDR A;  3NZ9 X;  4KEB A;  3QYO A;  4OR7 A;  2W3A A;  3ZPC A;  4KL9 A;  3CD2 A;  1DR2 A;  3FL9 A;  3DFR A;  4KYA A;  3K47 A;  1DR6 A;  3NTZ A;  1DR5 A;  3JWC A;  3SAI A;  4IXG X;  3SRU X;  1CD2 A;  1DRB A;  1RA8 A;  4XEC X;  3IRN A;  2H2Q A;  3QFX A;  4DPD A;  3GHC A;  3I8A X;  2AZN A;  3NZB X;  2BLA A;  1RC4 A;  1DDS A;  4XT7 A;  1RX1 A;  4KM0 A;  5U26 A;  1RA1 A;  2ANO A;  3QLR A;  3DGA A;  1HFP A;  3FQV A;  3QL3 A;  4I13 A;  1ZDR A;  4HA7 A;  4QJZ D;  4XT6 A;  1RX6 A;  3SQY X;  5HF0 X;  1LY3 A;  5U27 A;  3TQ8 A;  3QYL A;  4HOG A;  4RGC A;  1VDR A;  3RG9 A;  4X5G A;  2W9G A;  4X5F A;  3NXY A;  5E8Q A;  4ECK A;  5ECC A;  1D1G A;  3F0S X;  5EAJ A;  3S9U A;  1U71 A;  3INV A;  3UM5 A;  7DFR A;  4X5H A;  3IX9 A;  1OHJ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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