3K7VC

Protein phosphatase 2a core complex bound to dinophysistoxin-1
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structural basis for the reduced toxicity of dinophysistoxin-2.
pubmed doi rcsb
molecule tags Signaling protein/hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 107
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3k7vC00
2HYOA 3P71C 4IL1A 4O4KA 2QFRA 4O43A 1IT6A 3E7BA 4JA9A 4Q7FA 4LTYA 3K7VC 3IVDA 1Z2WA 3IVEA 4HD0A 5INBA 2BQ8X 3C5WC 4I5LC 4V0WA 4FCXA 4IYPC 1QHWA 5JPFA 3H61A 2P6BA 5DNYA 3PSOA 1HO5A 2QJCA 4FBQA 4UT2A 5IOHA 3N5UA 1WARA 3DSDA 2BCDA 2IAEC 4KBPA 1KBPA 1OI8A 3ICFA 1II7A 4H1YP 4MP0A 5JJTA 2GJUA 3IB7A 1SU1A 2WDDA 2CV9A 2Z06A 5JPEA 1MF8A 4H2FA 2R17A 4DHLA 3H60A 2XMOA 5GTUA 1M63A 4H2GA 1W24A 1S3LA 1S3MA 2Q8UA 2YVTA 3FGAC 3H64A 1S8EA 1HP1A 1V73A 3QFMA 4O24A 1USHA 1OIDA 1UTEA 4M0VA 1TCOA 3QFOA 4JA7A 3JYFA 5HPEA 2HYPA 1T70A 3T1IA 4I5NC 4FBKA 4YKEA 2Z72A 4ORCA 4V0XA 3QG5C 1S95A 3E7AA 2DFJA 4KKZA 1S70A 2KKNA 1FJMA 4UT3B 4DT2A 1OIEA 2NYMC 1XZWA 2IE4C 3AV0A 3HVQA 1HPUA 1WAO1 2JOGA 3QFNA 4H2IA 4UT3A 3H66A 4J6OA 3LL8A 1S3NA 5B8IA 2WDCA 3DW8C 5J28A 3EGHA 3H62B 2A22A 2QFPA 2O8AA 4MOYA 5EQVA 1AUIA 2AHDA 3H67A 1Z2XA 2NYLC 4H1SA 4OR9A 4ZX2A 1QFCA 3AUZA 1NNWA 2IE3C 2WDFA 3KBPA 4V0VA 3ZTVA 2NXFA 3C9FA 4LACC 2Z1AA 1JK7A 4ZVZA 3DSCA 4TUGA 3RL3A 1XM7A 3QFKA 2NPPC 4UWQA 1G5BA 3K7WC 4G9JA 2BDXA 3V4YA 2WDEA 1T71A 3PSNA 2O8GA 1U32A 3H63A 3THNA 4DSYA 4XPNA 3THOB 5C1VA 3H68A 3H69A 2HY1A 3CK2A 3RQZA 2ZBMA 4MOVA 3TGHA 2USHA 4B2OA 3GVEA 3RL5A 3RL4A 4H2BA 4F0ZA 4NZVA 1UF3A 4WWLA 4TUIA 4LU9A 4ORBA 4ORAA 3ZU0A 3EGGA 4O5GA 3IB8A 5F3WA 4FBWA
chains in the Genus database with same CATH superfamily
2HYOA 3P71C 4IL1A 4O4KA 2QFRA 4O43A 1IT6A 3E7BA 4JA9A 4Q7FA 4LTYA 3K7VC 3IVDA 1Z2WA 3IVEA 3E0JA 4HD0A 5INBA 2BQ8X 3C5WC 4I5LC 4V0WA 4FCXA 4IYPC 1QHWA 5JPFA 3H61A 2P6BA 3D03A 5DNYA 3PSOA 1HO5A 2QJCA 4FBQA 4UT2A 5IOHA 3N5UA 1WARA 3DSDA 2BCDA 2IAEC 4KBPA 2DXLA 1KBPA 1OI8A 3ICFA 1II7A 4H1YP 4MP0A 5JJTA 2GJUA 3IB7A 1SU1A 2WDDA 2CV9A 2Z06A 5JPEA 1MF8A 4H2FA 2R17A 4DHLA 3H60A 2XMOA 5GTUA 1M63A 4H2GA 1W24A 1S3LA 1S3MA 2DXNA 2Q8UA 2YVTA 3FGAC 3H64A 1S8EA 1HP1A 1V73A 3QFMA 4O24A 1USHA 1OIDA 1UTEA 4M0VA 1TCOA 3QFOA 4JA7A 3JYFA 5HPEA 2HYPA 1T70A 3T1IA 4I5NC 4FBKA 4YKEA 2Z72A 2ZOAA 4ORCA 4V0XA 2YEQA 3QG5C 1S95A 3E7AA 2DFJA 4KKZA 1S70A 2KKNA 1FJMA 4UT3B 4DT2A 1OIEA 2NYMC 1XZWA 2IE4C 3AV0A 3HVQA 1HPUA 1WAO1 2JOGA 3QFNA 4H2IA 4UT3A 3H66A 4J6OA 3LL8A 1S3NA 5B8IA 2WDCA 3DW8C 5J28A 3EGHA 3H62B 2A22A 2QFPA 2ZO9B 2O8AA 4MOYA 5EQVA 1AUIA 2AHDA 3H67A 1Z2XA 2NYLC 4H1SA 4OR9A 4ZX2A 1QFCA 3AUZA 1NNWA 2IE3C 2WDFA 3KBPA 4V0VA 3ZTVA 2NXFA 3C9FA 3FLOA 2Z1AA 4LACC 1JK7A 4ZVZA 3DSCA 4TUGA 3RL3A 1XM7A 3QFKA 2NPPC 4UWQA 1G5BA 3K7WC 4G9JA 2BDXA 3V4YA 2WDEA 1T71A 3PSNA 2O8GA 1U32A 3H63A 3THNA 4DSYA 4XPNA 3THOB 5C1VA 3H68A 3H69A 2HY1A 3CK2A 3RQZA 2ZBMA 4MOVA 3TGHA 2USHA 4B2OA 3GVEA 3RL5A 3RL4A 4H2BA 4F0ZA 4NZVA 1UF3A 4WWLA 4TUIA 4LU9A 4ORBA 4ORAA 3ZU0A 3EGGA 4O5GA 3IB8A 5F3WA 4FBWA
chains in the Genus database with same CATH topology
2HYOA 3P71C 4IL1A 4O4KA 2QFRA 4O43A 1IT6A 3E7BA 4JA9A 4Q7FA 4LTYA 3K7VC 3IVDA 1Z2WA 3IVEA 3E0JA 4HD0A 5INBA 2BQ8X 3C5WC 4I5LC 4V0WA 4FCXA 4IYPC 1QHWA 5JPFA 3H61A 2P6BA 3D03A 5DNYA 3PSOA 1HO5A 2QJCA 4FBQA 4UT2A 5IOHA 3N5UA 1WARA 3DSDA 2BCDA 2IAEC 4KBPA 2DXLA 1KBPA 1OI8A 3ICFA 1II7A 4H1YP 4MP0A 5JJTA 2GJUA 3IB7A 1SU1A 2WDDA 2CV9A 2Z06A 5JPEA 1MF8A 4H2FA 2R17A 4DHLA 3H60A 2XMOA 5GTUA 1M63A 4H2GA 1W24A 1S3LA 1S3MA 2DXNA 2Q8UA 2YVTA 3FGAC 3H64A 1S8EA 1HP1A 1V73A 3QFMA 4O24A 1USHA 1OIDA 1UTEA 4M0VA 1TCOA 3QFOA 4JA7A 3JYFA 5HPEA 2HYPA 1T70A 3T1IA 4I5NC 4FBKA 4YKEA 2Z72A 2ZOAA 4ORCA 4V0XA 2YEQA 3QG5C 1S95A 3E7AA 2DFJA 4KKZA 1S70A 2KKNA 1FJMA 4UT3B 4DT2A 1OIEA 2NYMC 1XZWA 2IE4C 3AV0A 3HVQA 1HPUA 1WAO1 2JOGA 3QFNA 4H2IA 4UT3A 3H66A 4J6OA 3LL8A 1S3NA 5B8IA 2WDCA 3DW8C 5J28A 3EGHA 3H62B 2A22A 2QFPA 2ZO9B 2O8AA 4MOYA 5EQVA 1AUIA 2AHDA 3H67A 1Z2XA 2NYLC 4H1SA 4OR9A 4ZX2A 1QFCA 3AUZA 1NNWA 2IE3C 2WDFA 3KBPA 4V0VA 3ZTVA 2NXFA 3C9FA 3FLOA 2Z1AA 4LACC 1JK7A 4ZVZA 3DSCA 4TUGA 3RL3A 1XM7A 3QFKA 2NPPC 4UWQA 1G5BA 3K7WC 4G9JA 2BDXA 3V4YA 2WDEA 1T71A 3PSNA 2O8GA 1U32A 3H63A 3THNA 4DSYA 4XPNA 3THOB 5C1VA 3H68A 3H69A 2HY1A 3CK2A 3RQZA 2ZBMA 4MOVA 3TGHA 2USHA 4B2OA 3GVEA 3RL5A 3RL4A 4H2BA 4F0ZA 4NZVA 1UF3A 4WWLA 4TUIA 4LU9A 4ORBA 4ORAA 3ZU0A 3EGGA 4O5GA 3IB8A 5F3WA 4FBWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HYO A;  3P71 C;  4IL1 A;  4O4K A;  2QFR A;  4O43 A;  1IT6 A;  3E7B A;  4JA9 A;  4Q7F A;  4LTY A;  3K7V C;  3IVD A;  1Z2W A;  3IVE A;  4HD0 A;  5INB A;  2BQ8 X;  3C5W C;  4I5L C;  4V0W A;  4FCX A;  4IYP C;  1QHW A;  5JPF A;  3H61 A;  2P6B A;  5DNY A;  3PSO A;  1HO5 A;  2QJC A;  4FBQ A;  4UT2 A;  5IOH A;  3N5U A;  1WAR A;  3DSD A;  2BCD A;  2IAE C;  4KBP A;  1KBP A;  1OI8 A;  3ICF A;  1II7 A;  4H1Y P;  4MP0 A;  5JJT A;  2GJU A;  3IB7 A;  1SU1 A;  2WDD A;  2CV9 A;  2Z06 A;  5JPE A;  1MF8 A;  4H2F A;  2R17 A;  4DHL A;  3H60 A;  2XMO A;  5GTU A;  1M63 A;  4H2G A;  1W24 A;  1S3L A;  1S3M A;  2Q8U A;  2YVT A;  3FGA C;  3H64 A;  1S8E A;  1HP1 A;  1V73 A;  3QFM A;  4O24 A;  1USH A;  1OID A;  1UTE A;  4M0V A;  1TCO A;  3QFO A;  4JA7 A;  3JYF A;  5HPE A;  2HYP A;  1T70 A;  3T1I A;  4I5N C;  4FBK A;  4YKE A;  2Z72 A;  4ORC A;  4V0X A;  3QG5 C;  1S95 A;  3E7A A;  2DFJ A;  4KKZ A;  1S70 A;  2KKN A;  1FJM A;  4UT3 B;  4DT2 A;  1OIE A;  2NYM C;  1XZW A;  2IE4 C;  3AV0 A;  3HVQ A;  1HPU A;  1WAO 1;  2JOG A;  3QFN A;  4H2I A;  4UT3 A;  3H66 A;  4J6O A;  3LL8 A;  1S3N A;  5B8I A;  2WDC A;  3DW8 C;  5J28 A;  3EGH A;  3H62 B;  2A22 A;  2QFP A;  2O8A A;  4MOY A;  5EQV A;  1AUI A;  2AHD A;  3H67 A;  1Z2X A;  2NYL C;  4H1S A;  4OR9 A;  4ZX2 A;  1QFC A;  3AUZ A;  1NNW A;  2IE3 C;  2WDF A;  3KBP A;  4V0V A;  3ZTV A;  2NXF A;  3C9F A;  4LAC C;  2Z1A A;  1JK7 A;  4ZVZ A;  3DSC A;  4TUG A;  3RL3 A;  1XM7 A;  3QFK A;  2NPP C;  4UWQ A;  1G5B A;  3K7W C;  4G9J A;  2BDX A;  3V4Y A;  2WDE A;  1T71 A;  3PSN A;  2O8G A;  1U32 A;  3H63 A;  3THN A;  4DSY A;  4XPN A;  3THO B;  5C1V A;  3H68 A;  3H69 A;  2HY1 A;  3CK2 A;  3RQZ A;  2ZBM A;  4MOV A;  3TGH A;  2USH A;  4B2O A;  3GVE A;  3RL5 A;  3RL4 A;  4H2B A;  4F0Z A;  4NZV A;  1UF3 A;  4WWL A;  4TUI A;  4LU9 A;  4ORB A;  4ORA A;  3ZU0 A;  3EGG A;  4O5G A;  3IB8 A;  5F3W A;  4FBW A; 
#chains in the Genus database with same CATH topology
 2HYO A;  3P71 C;  4IL1 A;  4O4K A;  2QFR A;  4O43 A;  1IT6 A;  3E7B A;  4JA9 A;  4Q7F A;  4LTY A;  3K7V C;  3IVD A;  1Z2W A;  3IVE A;  3E0J A;  4HD0 A;  5INB A;  2BQ8 X;  3C5W C;  4I5L C;  4V0W A;  4FCX A;  4IYP C;  1QHW A;  5JPF A;  3H61 A;  2P6B A;  3D03 A;  5DNY A;  3PSO A;  1HO5 A;  2QJC A;  4FBQ A;  4UT2 A;  5IOH A;  3N5U A;  1WAR A;  3DSD A;  2BCD A;  2IAE C;  4KBP A;  2DXL A;  1KBP A;  1OI8 A;  3ICF A;  1II7 A;  4H1Y P;  4MP0 A;  5JJT A;  2GJU A;  3IB7 A;  1SU1 A;  2WDD A;  2CV9 A;  2Z06 A;  5JPE A;  1MF8 A;  4H2F A;  2R17 A;  4DHL A;  3H60 A;  2XMO A;  5GTU A;  1M63 A;  4H2G A;  1W24 A;  1S3L A;  1S3M A;  2DXN A;  2Q8U A;  2YVT A;  3FGA C;  3H64 A;  1S8E A;  1HP1 A;  1V73 A;  3QFM A;  4O24 A;  1USH A;  1OID A;  1UTE A;  4M0V A;  1TCO A;  3QFO A;  4JA7 A;  3JYF A;  5HPE A;  2HYP A;  1T70 A;  3T1I A;  4I5N C;  4FBK A;  4YKE A;  2Z72 A;  2ZOA A;  4ORC A;  4V0X A;  2YEQ A;  3QG5 C;  1S95 A;  3E7A A;  2DFJ A;  4KKZ A;  1S70 A;  2KKN A;  1FJM A;  4UT3 B;  4DT2 A;  1OIE A;  2NYM C;  1XZW A;  2IE4 C;  3AV0 A;  3HVQ A;  1HPU A;  1WAO 1;  2JOG A;  3QFN A;  4H2I A;  4UT3 A;  3H66 A;  4J6O A;  3LL8 A;  1S3N A;  5B8I A;  2WDC A;  3DW8 C;  5J28 A;  3EGH A;  3H62 B;  2A22 A;  2QFP A;  2ZO9 B;  2O8A A;  4MOY A;  5EQV A;  1AUI A;  2AHD A;  3H67 A;  1Z2X A;  2NYL C;  4H1S A;  4OR9 A;  4ZX2 A;  1QFC A;  3AUZ A;  1NNW A;  2IE3 C;  2WDF A;  3KBP A;  4V0V A;  3ZTV A;  2NXF A;  3C9F A;  3FLO A;  2Z1A A;  4LAC C;  1JK7 A;  4ZVZ A;  3DSC A;  4TUG A;  3RL3 A;  1XM7 A;  3QFK A;  2NPP C;  4UWQ A;  1G5B A;  3K7W C;  4G9J A;  2BDX A;  3V4Y A;  2WDE A;  1T71 A;  3PSN A;  2O8G A;  1U32 A;  3H63 A;  3THN A;  4DSY A;  4XPN A;  3THO B;  5C1V A;  3H68 A;  3H69 A;  2HY1 A;  3CK2 A;  3RQZ A;  2ZBM A;  4MOV A;  3TGH A;  2USH A;  4B2O A;  3GVE A;  3RL5 A;  3RL4 A;  4H2B A;  4F0Z A;  4NZV A;  1UF3 A;  4WWL A;  4TUI A;  4LU9 A;  4ORB A;  4ORA A;  3ZU0 A;  3EGG A;  4O5G A;  3IB8 A;  5F3W A;  4FBW A; 
#chains in the Genus database with same CATH homology
 2HYO A;  3P71 C;  4IL1 A;  4O4K A;  2QFR A;  4O43 A;  1IT6 A;  3E7B A;  4JA9 A;  4Q7F A;  4LTY A;  3K7V C;  3IVD A;  1Z2W A;  3IVE A;  3E0J A;  4HD0 A;  5INB A;  2BQ8 X;  3C5W C;  4I5L C;  4V0W A;  4FCX A;  4IYP C;  1QHW A;  5JPF A;  3H61 A;  2P6B A;  3D03 A;  5DNY A;  3PSO A;  1HO5 A;  2QJC A;  4FBQ A;  4UT2 A;  5IOH A;  3N5U A;  1WAR A;  3DSD A;  2BCD A;  2IAE C;  4KBP A;  2DXL A;  1KBP A;  1OI8 A;  3ICF A;  1II7 A;  4H1Y P;  4MP0 A;  5JJT A;  2GJU A;  3IB7 A;  1SU1 A;  2WDD A;  2CV9 A;  2Z06 A;  5JPE A;  1MF8 A;  4H2F A;  2R17 A;  4DHL A;  3H60 A;  2XMO A;  5GTU A;  1M63 A;  4H2G A;  1W24 A;  1S3L A;  1S3M A;  2DXN A;  2Q8U A;  2YVT A;  3FGA C;  3H64 A;  1S8E A;  1HP1 A;  1V73 A;  3QFM A;  4O24 A;  1USH A;  1OID A;  1UTE A;  4M0V A;  1TCO A;  3QFO A;  4JA7 A;  3JYF A;  5HPE A;  2HYP A;  1T70 A;  3T1I A;  4I5N C;  4FBK A;  4YKE A;  2Z72 A;  2ZOA A;  4ORC A;  4V0X A;  2YEQ A;  3QG5 C;  1S95 A;  3E7A A;  2DFJ A;  4KKZ A;  1S70 A;  2KKN A;  1FJM A;  4UT3 B;  4DT2 A;  1OIE A;  2NYM C;  1XZW A;  2IE4 C;  3AV0 A;  3HVQ A;  1HPU A;  1WAO 1;  2JOG A;  3QFN A;  4H2I A;  4UT3 A;  3H66 A;  4J6O A;  3LL8 A;  1S3N A;  5B8I A;  2WDC A;  3DW8 C;  5J28 A;  3EGH A;  3H62 B;  2A22 A;  2QFP A;  2ZO9 B;  2O8A A;  4MOY A;  5EQV A;  1AUI A;  2AHD A;  3H67 A;  1Z2X A;  2NYL C;  4H1S A;  4OR9 A;  4ZX2 A;  1QFC A;  3AUZ A;  1NNW A;  2IE3 C;  2WDF A;  3KBP A;  4V0V A;  3ZTV A;  2NXF A;  3C9F A;  3FLO A;  2Z1A A;  4LAC C;  1JK7 A;  4ZVZ A;  3DSC A;  4TUG A;  3RL3 A;  1XM7 A;  3QFK A;  2NPP C;  4UWQ A;  1G5B A;  3K7W C;  4G9J A;  2BDX A;  3V4Y A;  2WDE A;  1T71 A;  3PSN A;  2O8G A;  1U32 A;  3H63 A;  3THN A;  4DSY A;  4XPN A;  3THO B;  5C1V A;  3H68 A;  3H69 A;  2HY1 A;  3CK2 A;  3RQZ A;  2ZBM A;  4MOV A;  3TGH A;  2USH A;  4B2O A;  3GVE A;  3RL5 A;  3RL4 A;  4H2B A;  4F0Z A;  4NZV A;  1UF3 A;  4WWL A;  4TUI A;  4LU9 A;  4ORB A;  4ORA A;  3ZU0 A;  3EGG A;  4O5G A;  3IB8 A;  5F3W A;  4FBW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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