3K7WC

Protein phosphatase 2a core complex bound to dinophysistoxin-2
Total Genus 108
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
108
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structural basis for the reduced toxicity of dinophysistoxin-2.
pubmed doi rcsb
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
molecule tags Signaling protein/hydrolase
source organism Homo sapiens
total genus 108
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3k7wC00
1MF8A 3H69A 2GJUA 3K7WC 2QJCA 3QFNA 4UT2A 3TGHA 2O8GA 2DFJA 4MP0A 3K7VC 2QFPA 3KBPA 3GVEA 3HVQA 3H64A 1Z2XA 2JOGA 3EGGA 4IYPC 3E7BA 3PSNA 2O8AA 3RL5A 3FGAC 4ORAA 4XPNA 5GTUA 3EGHA 1T70A 3H62B 1FJMA 2P6BA 2QFRA 3H61A 4UT3B 2BCDA 5JJTA 1UF3A 1XZWA 2Z72A 3N5UA 2HYPA 1Z2WA 1HPUA 3THNA 1S3LA 1XM7A 3AV0A 3AUZA 4H1SA 5EQVA 4NZVA 5JPEA 3CK2A 1HP1A 4KBPA 3T1IA 3DSCA 3H67A 4G9JA 1AUIA 3LL8A 4IL1A 2Q8UA 4O4KA 5HPEA 4F0ZA 4H2GA 2CV9A 4J6OA 3ZU0A 1V73A 4H2FA 4H2IA 4LACC 1OIEA 1IT6A 1S8EA 1NNWA 1WARA 3RQZA 3THOB 3P71C 2IE4C 4FBKA 4KKZA 2BQ8X 1SU1A 2WDCA 4DHLA 1S3NA 3DW8C 3QG5C 2XMOA 4JA7A 1II7A 2AHDA 1WAO1 2NYMC 4I5NC 4B2OA 2YVTA 4UT3A 4ZX2A 3QFKA 4I5LC 3DSDA 1KBPA 5DNYA 5B8IA 1S70A 5JPFA 2R17A 3C5WC 4H2BA 4MOVA 4O24A 3IB8A 4MOYA 4OR9A 4V0XA 2WDEA 3ZTVA 2IAEC 1UTEA 5J28A 3RL3A 4H1YP 4O43A 4FBQA 1TCOA 4WWLA 3ICFA 1U32A 1S95A 3IVEA 4FCXA 4Q7FA 1HO5A 4TUIA 3PSOA 2NYLC 1QHWA 4LTYA 2BDXA 1OIDA 2ZBMA 1QFCA 4UWQA 1JK7A 3C9FA 4YKEA 2WDFA 3QFMA 3E7AA 4TUGA 1M63A 3IB7A 4JA9A 3H66A 2HYOA 3V4YA 1W24A 1G5BA 1USHA 3H68A 3H60A 2HY1A 2KKNA 5IOHA 4DT2A 2WDDA 4ORBA 2Z1AA 3IVDA 4DSYA 3JYFA 4FBWA 3H63A 2NXFA 4ORCA 4ZVZA 5F3WA 1OI8A 4O5GA 2NPPC 2USHA 4HD0A 1T71A 2A22A 5C1VA 5INBA 1S3MA 4LU9A 2IE3C 4V0WA 2Z06A 4M0VA 3RL4A 4V0VA 3QFOA
chains in the Genus database with same CATH superfamily
1MF8A 3H69A 2GJUA 3K7WC 2QJCA 3QFNA 4UT2A 3TGHA 2O8GA 2DFJA 4MP0A 3K7VC 2QFPA 3KBPA 3GVEA 3HVQA 3H64A 1Z2XA 2JOGA 3EGGA 4IYPC 3E7BA 3PSNA 2O8AA 3RL5A 3FGAC 4ORAA 4XPNA 5GTUA 3EGHA 1T70A 3H62B 1FJMA 2P6BA 2QFRA 3H61A 4UT3B 2BCDA 5JJTA 1UF3A 1XZWA 2Z72A 3N5UA 2HYPA 1Z2WA 1HPUA 3THNA 1S3LA 1XM7A 3AV0A 3AUZA 4H1SA 5EQVA 4NZVA 5JPEA 3CK2A 1HP1A 4KBPA 3T1IA 3DSCA 3H67A 4G9JA 1AUIA 3LL8A 4IL1A 2Q8UA 4O4KA 5HPEA 4F0ZA 4H2GA 2CV9A 4J6OA 3ZU0A 1V73A 4H2FA 4H2IA 4LACC 1OIEA 1IT6A 1S8EA 1NNWA 1WARA 3RQZA 3THOB 3P71C 2IE4C 2DXLA 3D03A 3E0JA 2ZOAA 4FBKA 4KKZA 2BQ8X 1SU1A 2WDCA 4DHLA 1S3NA 3DW8C 3QG5C 2XMOA 4JA7A 1II7A 2AHDA 2ZO9B 1WAO1 2NYMC 4I5NC 4B2OA 2YVTA 4UT3A 4ZX2A 3QFKA 4I5LC 3DSDA 1KBPA 5B8IA 1S70A 5JPFA 2R17A 3C5WC 4H2BA 4MOVA 4O24A 3IB8A 4MOYA 2Z06A 4OR9A 4V0XA 2WDEA 3ZTVA 2IAEC 1UTEA 5J28A 3RL3A 4H1YP 4O43A 4FBQA 1TCOA 4WWLA 3ICFA 1U32A 1S95A 3IVEA 4FCXA 4Q7FA 1HO5A 4TUIA 3PSOA 2NYLC 1QHWA 4LTYA 2BDXA 1OIDA 2ZBMA 1QFCA 4UWQA 1JK7A 3C9FA 4YKEA 2WDFA 3QFMA 3E7AA 4TUGA 1M63A 3IB7A 4JA9A 3H66A 2HYOA 3V4YA 1W24A 1G5BA 1USHA 3H68A 3H60A 2HY1A 2KKNA 5IOHA 4DT2A 2WDDA 4ORBA 2Z1AA 3IVDA 4DSYA 3JYFA 4FBWA 2DXNA 3H63A 2YEQA 2NXFA 4ORCA 4ZVZA 5F3WA 1OI8A 4O5GA 2NPPC 2USHA 4HD0A 1T71A 3FLOA 2A22A 5C1VA 5INBA 4LU9A 4V0WA 2IE3C 3RL4A 1S3MA 4M0VA 5DNYA 4V0VA 3QFOA
chains in the Genus database with same CATH topology
1MF8A 3H69A 2GJUA 3K7WC 2QJCA 3QFNA 4UT2A 3TGHA 2O8GA 2DFJA 4MP0A 3K7VC 2QFPA 3KBPA 3GVEA 3HVQA 3H64A 1Z2XA 2JOGA 3EGGA 4IYPC 3E7BA 3PSNA 2O8AA 3RL5A 3FGAC 4ORAA 4XPNA 5GTUA 3EGHA 1T70A 3H62B 1FJMA 2P6BA 2QFRA 3H61A 4UT3B 2BCDA 5JJTA 1UF3A 1XZWA 2Z72A 3N5UA 2HYPA 1Z2WA 1HPUA 3THNA 1S3LA 1XM7A 3AV0A 3AUZA 4H1SA 5EQVA 4NZVA 5JPEA 3CK2A 1HP1A 4KBPA 3T1IA 3DSCA 3H67A 4G9JA 1AUIA 3LL8A 4IL1A 2Q8UA 4O4KA 5HPEA 4F0ZA 4H2GA 2CV9A 4J6OA 3ZU0A 1V73A 4H2FA 4H2IA 4LACC 1OIEA 1IT6A 1S8EA 1NNWA 1WARA 3RQZA 3THOB 3P71C 2IE4C 2DXLA 3D03A 3E0JA 2ZOAA 4FBKA 4KKZA 2BQ8X 1SU1A 2WDCA 4DHLA 1S3NA 3DW8C 3QG5C 2XMOA 4JA7A 1II7A 2AHDA 2ZO9B 1WAO1 2NYMC 4I5NC 4B2OA 2YVTA 4UT3A 4ZX2A 3QFKA 4I5LC 3DSDA 1KBPA 5B8IA 1S70A 5JPFA 2R17A 3C5WC 4H2BA 4MOVA 4O24A 3IB8A 4MOYA 2Z06A 4OR9A 4V0XA 2WDEA 3ZTVA 2IAEC 1UTEA 5J28A 3RL3A 4H1YP 4O43A 4FBQA 1TCOA 4WWLA 3ICFA 1U32A 1S95A 3IVEA 4FCXA 4Q7FA 1HO5A 4TUIA 3PSOA 2NYLC 1QHWA 4LTYA 2BDXA 1OIDA 2ZBMA 1QFCA 4UWQA 1JK7A 3C9FA 4YKEA 2WDFA 3QFMA 3E7AA 4TUGA 1M63A 3IB7A 4JA9A 3H66A 2HYOA 3V4YA 1W24A 1G5BA 1USHA 3H68A 3H60A 2HY1A 2KKNA 5IOHA 4DT2A 2WDDA 4ORBA 2Z1AA 3IVDA 4DSYA 3JYFA 4FBWA 2DXNA 3H63A 2YEQA 2NXFA 4ORCA 4ZVZA 5F3WA 1OI8A 4O5GA 2NPPC 2USHA 4HD0A 1T71A 3FLOA 2A22A 5C1VA 5INBA 4LU9A 4V0WA 2IE3C 3RL4A 1S3MA 4M0VA 5DNYA 4V0VA 3QFOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MF8 A;  3H69 A;  2GJU A;  3K7W C;  2QJC A;  3QFN A;  4UT2 A;  3TGH A;  2O8G A;  2DFJ A;  4MP0 A;  3K7V C;  2QFP A;  3KBP A;  3GVE A;  3HVQ A;  3H64 A;  1Z2X A;  2JOG A;  3EGG A;  4IYP C;  3E7B A;  3PSN A;  2O8A A;  3RL5 A;  3FGA C;  4ORA A;  4XPN A;  5GTU A;  3EGH A;  1T70 A;  3H62 B;  1FJM A;  2P6B A;  2QFR A;  3H61 A;  4UT3 B;  2BCD A;  5JJT A;  1UF3 A;  1XZW A;  2Z72 A;  3N5U A;  2HYP A;  1Z2W A;  1HPU A;  3THN A;  1S3L A;  1XM7 A;  3AV0 A;  3AUZ A;  4H1S A;  5EQV A;  4NZV A;  5JPE A;  3CK2 A;  1HP1 A;  4KBP A;  3T1I A;  3DSC A;  3H67 A;  4G9J A;  1AUI A;  3LL8 A;  4IL1 A;  2Q8U A;  4O4K A;  5HPE A;  4F0Z A;  4H2G A;  2CV9 A;  4J6O A;  3ZU0 A;  1V73 A;  4H2F A;  4H2I A;  4LAC C;  1OIE A;  1IT6 A;  1S8E A;  1NNW A;  1WAR A;  3RQZ A;  3THO B;  3P71 C;  2IE4 C;  4FBK A;  4KKZ A;  2BQ8 X;  1SU1 A;  2WDC A;  4DHL A;  1S3N A;  3DW8 C;  3QG5 C;  2XMO A;  4JA7 A;  1II7 A;  2AHD A;  1WAO 1;  2NYM C;  4I5N C;  4B2O A;  2YVT A;  4UT3 A;  4ZX2 A;  3QFK A;  4I5L C;  3DSD A;  1KBP A;  5DNY A;  5B8I A;  1S70 A;  5JPF A;  2R17 A;  3C5W C;  4H2B A;  4MOV A;  4O24 A;  3IB8 A;  4MOY A;  4OR9 A;  4V0X A;  2WDE A;  3ZTV A;  2IAE C;  1UTE A;  5J28 A;  3RL3 A;  4H1Y P;  4O43 A;  4FBQ A;  1TCO A;  4WWL A;  3ICF A;  1U32 A;  1S95 A;  3IVE A;  4FCX A;  4Q7F A;  1HO5 A;  4TUI A;  3PSO A;  2NYL C;  1QHW A;  4LTY A;  2BDX A;  1OID A;  2ZBM A;  1QFC A;  4UWQ A;  1JK7 A;  3C9F A;  4YKE A;  2WDF A;  3QFM A;  3E7A A;  4TUG A;  1M63 A;  3IB7 A;  4JA9 A;  3H66 A;  2HYO A;  3V4Y A;  1W24 A;  1G5B A;  1USH A;  3H68 A;  3H60 A;  2HY1 A;  2KKN A;  5IOH A;  4DT2 A;  2WDD A;  4ORB A;  2Z1A A;  3IVD A;  4DSY A;  3JYF A;  4FBW A;  3H63 A;  2NXF A;  4ORC A;  4ZVZ A;  5F3W A;  1OI8 A;  4O5G A;  2NPP C;  2USH A;  4HD0 A;  1T71 A;  2A22 A;  5C1V A;  5INB A;  1S3M A;  4LU9 A;  2IE3 C;  4V0W A;  2Z06 A;  4M0V A;  3RL4 A;  4V0V A;  3QFO A; 
#chains in the Genus database with same CATH topology
 1MF8 A;  3H69 A;  2GJU A;  3K7W C;  2QJC A;  3QFN A;  4UT2 A;  3TGH A;  2O8G A;  2DFJ A;  4MP0 A;  3K7V C;  2QFP A;  3KBP A;  3GVE A;  3HVQ A;  3H64 A;  1Z2X A;  2JOG A;  3EGG A;  4IYP C;  3E7B A;  3PSN A;  2O8A A;  3RL5 A;  3FGA C;  4ORA A;  4XPN A;  5GTU A;  3EGH A;  1T70 A;  3H62 B;  1FJM A;  2P6B A;  2QFR A;  3H61 A;  4UT3 B;  2BCD A;  5JJT A;  1UF3 A;  1XZW A;  2Z72 A;  3N5U A;  2HYP A;  1Z2W A;  1HPU A;  3THN A;  1S3L A;  1XM7 A;  3AV0 A;  3AUZ A;  4H1S A;  5EQV A;  4NZV A;  5JPE A;  3CK2 A;  1HP1 A;  4KBP A;  3T1I A;  3DSC A;  3H67 A;  4G9J A;  1AUI A;  3LL8 A;  4IL1 A;  2Q8U A;  4O4K A;  5HPE A;  4F0Z A;  4H2G A;  2CV9 A;  4J6O A;  3ZU0 A;  1V73 A;  4H2F A;  4H2I A;  4LAC C;  1OIE A;  1IT6 A;  1S8E A;  1NNW A;  1WAR A;  3RQZ A;  3THO B;  3P71 C;  2IE4 C;  2DXL A;  3D03 A;  3E0J A;  2ZOA A;  4FBK A;  4KKZ A;  2BQ8 X;  1SU1 A;  2WDC A;  4DHL A;  1S3N A;  3DW8 C;  3QG5 C;  2XMO A;  4JA7 A;  1II7 A;  2AHD A;  2ZO9 B;  1WAO 1;  2NYM C;  4I5N C;  4B2O A;  2YVT A;  4UT3 A;  4ZX2 A;  3QFK A;  4I5L C;  3DSD A;  1KBP A;  5B8I A;  1S70 A;  5JPF A;  2R17 A;  3C5W C;  4H2B A;  4MOV A;  4O24 A;  3IB8 A;  4MOY A;  2Z06 A;  4OR9 A;  4V0X A;  2WDE A;  3ZTV A;  2IAE C;  1UTE A;  5J28 A;  3RL3 A;  4H1Y P;  4O43 A;  4FBQ A;  1TCO A;  4WWL A;  3ICF A;  1U32 A;  1S95 A;  3IVE A;  4FCX A;  4Q7F A;  1HO5 A;  4TUI A;  3PSO A;  2NYL C;  1QHW A;  4LTY A;  2BDX A;  1OID A;  2ZBM A;  1QFC A;  4UWQ A;  1JK7 A;  3C9F A;  4YKE A;  2WDF A;  3QFM A;  3E7A A;  4TUG A;  1M63 A;  3IB7 A;  4JA9 A;  3H66 A;  2HYO A;  3V4Y A;  1W24 A;  1G5B A;  1USH A;  3H68 A;  3H60 A;  2HY1 A;  2KKN A;  5IOH A;  4DT2 A;  2WDD A;  4ORB A;  2Z1A A;  3IVD A;  4DSY A;  3JYF A;  4FBW A;  2DXN A;  3H63 A;  2YEQ A;  2NXF A;  4ORC A;  4ZVZ A;  5F3W A;  1OI8 A;  4O5G A;  2NPP C;  2USH A;  4HD0 A;  1T71 A;  3FLO A;  2A22 A;  5C1V A;  5INB A;  4LU9 A;  4V0W A;  2IE3 C;  3RL4 A;  1S3M A;  4M0V A;  5DNY A;  4V0V A;  3QFO A; 
#chains in the Genus database with same CATH homology
 1MF8 A;  3H69 A;  2GJU A;  3K7W C;  2QJC A;  3QFN A;  4UT2 A;  3TGH A;  2O8G A;  2DFJ A;  4MP0 A;  3K7V C;  2QFP A;  3KBP A;  3GVE A;  3HVQ A;  3H64 A;  1Z2X A;  2JOG A;  3EGG A;  4IYP C;  3E7B A;  3PSN A;  2O8A A;  3RL5 A;  3FGA C;  4ORA A;  4XPN A;  5GTU A;  3EGH A;  1T70 A;  3H62 B;  1FJM A;  2P6B A;  2QFR A;  3H61 A;  4UT3 B;  2BCD A;  5JJT A;  1UF3 A;  1XZW A;  2Z72 A;  3N5U A;  2HYP A;  1Z2W A;  1HPU A;  3THN A;  1S3L A;  1XM7 A;  3AV0 A;  3AUZ A;  4H1S A;  5EQV A;  4NZV A;  5JPE A;  3CK2 A;  1HP1 A;  4KBP A;  3T1I A;  3DSC A;  3H67 A;  4G9J A;  1AUI A;  3LL8 A;  4IL1 A;  2Q8U A;  4O4K A;  5HPE A;  4F0Z A;  4H2G A;  2CV9 A;  4J6O A;  3ZU0 A;  1V73 A;  4H2F A;  4H2I A;  4LAC C;  1OIE A;  1IT6 A;  1S8E A;  1NNW A;  1WAR A;  3RQZ A;  3THO B;  3P71 C;  2IE4 C;  2DXL A;  3D03 A;  3E0J A;  2ZOA A;  4FBK A;  4KKZ A;  2BQ8 X;  1SU1 A;  2WDC A;  4DHL A;  1S3N A;  3DW8 C;  3QG5 C;  2XMO A;  4JA7 A;  1II7 A;  2AHD A;  2ZO9 B;  1WAO 1;  2NYM C;  4I5N C;  4B2O A;  2YVT A;  4UT3 A;  4ZX2 A;  3QFK A;  4I5L C;  3DSD A;  1KBP A;  5B8I A;  1S70 A;  5JPF A;  2R17 A;  3C5W C;  4H2B A;  4MOV A;  4O24 A;  3IB8 A;  4MOY A;  2Z06 A;  4OR9 A;  4V0X A;  2WDE A;  3ZTV A;  2IAE C;  1UTE A;  5J28 A;  3RL3 A;  4H1Y P;  4O43 A;  4FBQ A;  1TCO A;  4WWL A;  3ICF A;  1U32 A;  1S95 A;  3IVE A;  4FCX A;  4Q7F A;  1HO5 A;  4TUI A;  3PSO A;  2NYL C;  1QHW A;  4LTY A;  2BDX A;  1OID A;  2ZBM A;  1QFC A;  4UWQ A;  1JK7 A;  3C9F A;  4YKE A;  2WDF A;  3QFM A;  3E7A A;  4TUG A;  1M63 A;  3IB7 A;  4JA9 A;  3H66 A;  2HYO A;  3V4Y A;  1W24 A;  1G5B A;  1USH A;  3H68 A;  3H60 A;  2HY1 A;  2KKN A;  5IOH A;  4DT2 A;  2WDD A;  4ORB A;  2Z1A A;  3IVD A;  4DSY A;  3JYF A;  4FBW A;  2DXN A;  3H63 A;  2YEQ A;  2NXF A;  4ORC A;  4ZVZ A;  5F3W A;  1OI8 A;  4O5G A;  2NPP C;  2USH A;  4HD0 A;  1T71 A;  3FLO A;  2A22 A;  5C1V A;  5INB A;  4LU9 A;  4V0W A;  2IE3 C;  3RL4 A;  1S3M A;  4M0V A;  5DNY A;  4V0V A;  3QFO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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