3KL6B

Discovery of tetrahydropyrimidin-2(1h)-one derivative tak-442: a potent, selective and orally active factor xa inhibitor
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
50
structure length
50
Chain Sequence
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Coagulation Factor X heavy chain
total genus 12
structure length 50
sequence length 50
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2009-11-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 3kl6B00
1NQLB 3LTGD 1IQFL 4Z6AL 2P3UA 2P3FL 3N8YA 4JYUL 2H9EL 3ZYJB 2VH0B 1XFEA 4O1ZA 1NPEB 1LQDA 2I9AA 2J95B 4OTJA 1A3PA 1WHFA 3QMOA 4Y76B 2BO2A 1FSBA 1LPKA 4XL1A 4BTIA 4CUFA 4BTTA 1N1IA 1IJQA 2XC0L 3FCSB 1WHEA 1PFXL 3H5CB 3BT1A 2WFXB 4ISIL 5IKTA 2UWPB 1CCFA 3LC3B 2UWLB 2W2QE 2W2OE 2WPHE 1F7MA 2XBWL 3POYA 1U67A 2WPIE 1HX2A 5F1AA 2FZZL 1IQHL 2FD6A 1EBVA 4D0FA 2XC4L 2ADXA 1L5GB 5JBBE 1L3YA 3NTBA 2BQWA 4ZXXL 1IGZA 1IQJL 4Z0LA 5KIRA 2Y38A 5I46L 5JB8E 2I9BA 2W2ME 5JVZA 3HS6A 4ISHL 2B7DL 1IQNL 2VWOL 4Z0KB 4AQTA 1FJSL 5IKQA 5K0HB 4TGFA 1LPGA 3CFWA 3TBDA 1WU1B 1XDTR 1MQ5L 3TZIA 4CUEA 1IQIL 2OYEP 2BOXA 3SOQA 1F0SB 1YUKB 1KIGL 1QFKL 1HAEA 3LAQA 2Y5HL 1DX5I 5COXA 1LPZA 1NFWB 1YGCL 3HO3A 1CVWL 1HREA 1O5DL 4JZDL 5JBCE 2WG3C 2YGOA 1ATEA 1TPGA 2J94B 3FBYA 4LORA 1OB1C 1Z6CA 5CKMA 2WYJB 2MGPA 1HCGB 1IQML 1CX2A 1Q4GA 5JVYA 5IKVA 1FFMA 1EQHA 4RUTA 1NFUB 1APQA 1TOZA 3NTGA 3MQEA 4Y79B 3BPSE 1EPGA 2OYUP 3ASIA 4MMXB 1K37A 5CKNA 4Y71B 1JL9A 3LTFB 1CVUA 4XLWA 2VVUL 2WYGB 3ELAL 2WPJE 1URKA 3KQBL 3HPTA 1K36A 3TK5B 1IQEL 2EI7B 2P95L 1IGXA 2VJ3A 2J34B 2W3KB 1IOXA 3KK6A 3ZYIB 1EQGA 2W2PE 1FF7A 4X8TL 3LN1A 3HS5A 1P0SL 2K2SB 3NJPC 1IP0A 1IVOC 1PGEA 1M1XB 3OLTA 2KL7A 1NT0A 2M74A 2BZ6L 2Y7ZB 3GISX 3U73A 1HAFA 2RA0L 2D1JB 2EI6B 5CKQA 1EMNA 1COUA 3TGFA 5KN5C 3KCGL 4E1GA 2BOHA 3LN0A 3N8VA 3IITB 1CQEA 4ZAEB 2NPRA 3M37L 1FAXL 3TH3L 1F0RB 2J2UB 1KLJL 1ATDA 2W26B 3F1SB 2BOKL 1G1QA 2Y82B 2FLBL 1G1SA 2FLGA 4Y6DB 5L2YL 2P3TA 4BTUA 4JZEL 5IKRA 4ZXYL 2J38B 2VVCK 4BDWA 1DDXA 2WPKE 2P26A 3K9XA 1NFYB 2K2TA 2MHPA 3RR3A 2JKHL 2W86A 1CCVA 4BDXA 1NFXB 2RNLA 2VWLL 1EGFA 3GCWE 4RS0A 1EPJA 3KQEL 2BQ7A 4Y7BB 5EGMB 1PTHA 5JB9E 1G1TA 1APOA 2BMGA 1IOEL 1EAIC 3P5BL 3PGHA 4FM5A 2FLRL 4MMZB 3CS7L 4D90A 1FE2A 2W3IB 2XBVL 4D0EA 3FFGL 4JZFL 2Y7XB 2PHBB 2EI8B 3HS7A 1DQBA 3M36L 4RRWA 5JW1A 4OTYA 4X8UL 1JV2B 1Z6EL 2XBYL 1KSNB 2XBXL 5FDQA 1ATBA 3QCWA 2BQ6A 4COXA 3KL6B 1LMJA 1HRFA 1EZQB 1V3XB 3KQCL 2J4IB 1U8CB 1ADXA 5E8DA 1IQGL 2PUQL 1B9WA 2VH6B 1G1RA 1AUTL 2P3FN 2RHPA 4CUDA 1XKBA 4ZHAB 3N8XA 4PH9A 3SOVA 4NA9L 3SOBB 2YGPA 1ATAA 2PR3B 3DEMA 2CJIB 4YT6L 4A7IA 2DDUA 3Q7DA 1P9JA 1N7DA 4BXSA 3HO5A 1NZIA 4YT7L 1W8BL 2TGFA 2Q1JB 4RRZA 4X8SL 2KB9A 3KQDL 3V64C 3KRKA 1UZKA 3CA7A 2P93L 3LC5B 2KV4A 3SW2A 2WPME 2MGRA 3ZYGA 3V65B 2AYLA 1DVAL 1JBUL 2BOUA 2Y81B 1MQ6L 4MMYB 1KLIL 2Y80B 1F7EA 4M11A 1HT8A 4YZUB 5L30L 3N8YB 2XC5L 3Q3KB 5F19A 1UZQA 4O02B 3ENSA 2P16L 1HT5A 5L2ZL 1EPHA 1EPIA 4RRYA 4M10A 1FAKL 2WPLE 1X7AL 1ZAQA 3C9AC 1DIYA 4G1MB 2WG4B 1MOXC 1KLOA 1TLEA 1BF9A 1EMOA 3TK6B 3HO4A 1SZBA 1CEJA 3NT1A 4CSYA 1PXXA 3EGFA 3BT2A 3QH0A 5CISA 2G00L 1IQLL 1IQKL 2VWMK 3IJEB 3OLUA 1YUFA 4XBMA 3LIWB 1C5MF 1UZJA 1W7XL 2Y5GL 2Y5FL 1HZ8A 3N8WB 1PRHA 3F6UL 4JYVL 3CENL 1GK5A 1J9CL 2F9BL 1YUGA 1HJ7A 2P28B 6COXA 2GD4A 1G2LB 3N8WA 1UZPA 3MDLA 2UWOB 3N8ZA 4Y7AB 1XKAL 3GCXE 1I0UA 2W2NE 3R05A 5JBAE 1RFNB 3U7UG 4LMFA 4ZH8B 4BXWA 4C16A 1YO8A 1G2MB 4X8VL 2WFTA 2P94L 4NGAL 4RRXA 4NG9L 2VWNL 2VVVL
chains in the Genus database with same CATH superfamily
1NQLB 3LTGD 1IQFL 2VRSA 4Z6AL 2P3UA 2P3FL 3N8YA 4JYUL 2H9EL 3ZYJB 2VH0B 1XFEA 4O1ZA 1NPEB 1LQDA 2I9AA 4A94C 2J95B 4OTJA 1A3PA 1WHFA 3QMOA 4Y76B 2BO2A 1FSBA 1LPKA 4XL1A 4BTIA 4CUFA 4BTTA 1N1IA 1IJQA 2XC0L 3FCSB 1WHEA 1PFXL 3H5CB 3BT1A 2WFXB 4ISIL 5IKTA 2UWPB 1CCFA 3LC3B 2UWLB 2W2QE 2W2OE 2WPHE 1F7MA 2XBWL 3POYA 1U67A 2WPIE 1HX2A 5F1AA 2FZZL 2JJLA 1IQHL 2FD6A 1EBVA 4D0FA 2XC4L 2ADXA 1L5GB 5JBBE 1L3YA 3NTBA 2BQWA 4ZXXL 1IGZA 1IQJL 4Z0LA 5KIRA 2Y38A 5I46L 5JB8E 2I9BA 2W2ME 5JVZA 3HS6A 4ISHL 2B7DL 1IQNL 2VWOL 4Z0KB 4AQTA 1FJSL 5IKQA 5K0HB 4TGFA 1LPGA 3CFWA 3TBDA 1LK9A 1WU1B 1XDTR 1MQ5L 3TZIA 4CUEA 1IQIL 2OYEP 2BOXA 3SOQA 1F0SB 1YUKB 1KIGL 1QFKL 1HAEA 3LAQA 2Y5HL 1DX5I 5COXA 1LPZA 2HORA 1NFWB 1YGCL 3HO3A 1CVWL 1HREA 1O5DL 4JZDL 5JBCE 2WG3C 2YGOA 1ATEA 1TPGA 2J94B 3FBYA 4LORA 1OB1C 1Z6CA 5CKMA 2WYJB 2MGPA 1HCGB 1IQML 1CX2A 1Q4GA 5JVYA 5IKVA 1FFMA 2WZPP 1EQHA 4RUTA 1NFUB 1APQA 1TOZA 3NTGA 3MQEA 4Y79B 4GU3A 3BPSE 1EPGA 2OYUP 3ASIA 4MMXB 1K37A 5CKNA 4Y71B 1JL9A 3LTFB 1CVUA 4XLWA 2VVUL 2WYGB 3ELAL 2WPJE 1URKA 3KQBL 3HPTA 1K36A 3TK5B 1IQEL 2EI7B 2P95L 1IGXA 2VJ3A 2J34B 2W3KB 1IOXA 3KK6A 3ZYIB 1EQGA 2W2PE 1FF7A 1KKEA 4X8TL 3LN1A 3HS5A 1P0SL 2K2SB 3NJPC 1IP0A 1IVOC 1PGEA 1M1XB 3OLTA 2KL7A 1NT0A 2M74A 2BZ6L 2Y7ZB 3GISX 3U73A 1HAFA 2RA0L 2D1JB 2EI6B 5CKQA 1EMNA 1COUA 3TGFA 5KN5C 3KCGL 4E1GA 2BOHA 3LN0A 3N8VA 3IITB 1CQEA 2BT8A 4ZAEB 2NPRA 3M37L 1FAXL 3TH3L 1F0RB 2J2UB 1KLJL 1ATDA 2W26B 3F1SB 2BOKL 1G1QA 2Y82B 2FLBL 1G1SA 2FLGA 4Y6DB 5L2YL 2P3TA 4BTUA 4JZEL 5IKRA 4ZXYL 2J38B 2VVCK 4BDWA 1DDXA 2WPKE 2P26A 3K9XA 1NFYB 2K2TA 2MHPA 3RR3A 2JKHL 2W86A 1CCVA 4BDXA 1NFXB 2RNLA 2VWLL 1EGFA 3GCWE 4RS0A 1EPJA 3KQEL 2BQ7A 4Y7BB 5EGMB 1PTHA 5JB9E 1G1TA 1APOA 2BMGA 1IOEL 1EAIC 3P5BL 3PGHA 4FM5A 2FLRL 4MMZB 3CS7L 4D90A 1FE2A 2W3IB 2XBVL 4D0EA 3FFGL 4JZFL 2Y7XB 2PHBB 2EI8B 3HS7A 1DQBA 3M36L 4RRWA 5JW1A 4OTYA 4X8UL 1JV2B 1Z6EL 2XBYL 1KSNB 2XBXL 5FDQA 1ATBA 3QCWA 2BQ6A 4COXA 3KL6B 1LMJA 1HRFA 1EZQB 1V3XB 3KQCL 2J4IB 1U8CB 1ADXA 5E8DA 1IQGL 2PUQL 1B9WA 2VH6B 2H9EC 1G1RA 1V1IA 1AUTL 2P3FN 2RHPA 4CUDA 1XKBA 4ZHAB 3N8XA 4PH9A 3SOVA 4NA9L 3SOBB 2YGPA 1ATAA 2PR3B 3DEMA 2CJIB 4YT6L 2KNIA 4A7IA 2DDUA 3Q7DA 1P9JA 1N7DA 4BXSA 3HO5A 1NZIA 4YT7L 2YGQA 1W8BL 2TGFA 2Q1JB 4RRZA 4X8SL 2KB9A 3KQDL 3V64C 3KRKA 1QIUA 1UZKA 3CA7A 2P93L 2HOXA 3LC5B 2BT7A 2KV4A 3SW2A 2WPME 2MGRA 3ZYGA 3V65B 2AYLA 1DVAL 1JBUL 2BOUA 2Y81B 1LMMA 1MQ6L 4MMYB 1KLIL 2Y80B 4GU4A 4M11A 1F7EA 1HT8A 4YZUB 5L30L 3N8YB 2XC5L 3Q3KB 5F19A 1UZQA 4O02B 3ENSA 2P16L 3S6XA 1HT5A 5L2ZL 1EPHA 1EPIA 4RRYA 4M10A 1FAKL 2WPLE 1X7AL 1ZAQA 3C9AC 1DIYA 4G1MB 2WG4B 1MOXC 1KLOA 2BSFA 1TLEA 1BF9A 1EMOA 3TK6B 3HO4A 1SZBA 1CEJA 3NT1A 4CSYA 1PXXA 3EGFA 3BT2A 3QH0A 5CISA 2G00L 1IQLL 1IQKL 1V1HA 2VWMK 3IJEB 3OLUA 1YUFA 4XBMA 3LIWB 1C5MF 1UZJA 1W7XL 2Y5GL 2Y5FL 1HZ8A 3N8WB 1PRHA 3F6UL 4JYVL 3CENL 1GK5A 1J9CL 2F9BL 1YUGA 1HJ7A 2P28B 6COXA 2GD4A 1G2LB 3N8WA 1UZPA 3MDLA 2UWOB 3N8ZA 4Y7AB 1XKAL 3GCXE 1I0UA 2W2NE 3R05A 5JBAE 1RFNB 3U7UG 4LMFA 4ZH8B 4BXWA 4C16A 1YO8A 1G2MB 4X8VL 2WFTA 2P94L 4NGAL 4RRXA 4NG9L 2VWNL 2VVVL
chains in the Genus database with same CATH topology
1NQLB 3LTGD 1IQFL 4Z6AL 2P3UA 2P3FL 3N8YA 4JYUL 2H9EL 3ZYJB 2VH0B 1XFEA 4O1ZA 1NPEB 1LQDA 2I9AA 4A94C 2J95B 4OTJA 1A3PA 1WHFA 3QMOA 4Y76B 2BO2A 1FSBA 1LPKA 4XL1A 4BTIA 4CUFA 4BTTA 1N1IA 1IJQA 2XC0L 3FCSB 1WHEA 1PFXL 3H5CB 3BT1A 2WFXB 4ISIL 5IKTA 2UWPB 1CCFA 3LC3B 2UWLB 2W2QE 2W2OE 2WPHE 1F7MA 2XBWL 3POYA 1U67A 2WPIE 1HX2A 5F1AA 2FZZL 1IQHL 2FD6A 1EBVA 4D0FA 2XC4L 2ADXA 1L5GB 5JBBE 1L3YA 3NTBA 2BQWA 4ZXXL 1IGZA 1IQJL 4Z0LA 5KIRA 2Y38A 5I46L 5JB8E 2I9BA 2W2ME 5JVZA 3HS6A 4ISHL 2B7DL 1IQNL 2VWOL 4Z0KB 4AQTA 1FJSL 5IKQA 5K0HB 4TGFA 1LPGA 3CFWA 3TBDA 1WU1B 1XDTR 1MQ5L 3TZIA 4CUEA 1IQIL 2OYEP 2BOXA 3SOQA 1F0SB 1YUKB 1KIGL 1QFKL 1HAEA 3LAQA 2Y5HL 1DX5I 5COXA 1LPZA 1NFWB 1YGCL 3HO3A 1CVWL 1HREA 1O5DL 4JZDL 5JBCE 2WG3C 2YGOA 1ATEA 1TPGA 2J94B 3FBYA 4LORA 1OB1C 1Z6CA 5CKMA 2WYJB 2MGPA 1HCGB 1IQML 1CX2A 1Q4GA 5JVYA 5IKVA 1FFMA 2WZPP 1EQHA 4RUTA 1NFUB 1APQA 1TOZA 3NTGA 3MQEA 4Y79B 3BPSE 1EPGA 2OYUP 3ASIA 4MMXB 1K37A 5CKNA 4Y71B 1JL9A 3LTFB 1CVUA 4XLWA 2VVUL 2WYGB 3ELAL 2WPJE 1URKA 3KQBL 3HPTA 1K36A 3TK5B 1IQEL 2EI7B 2P95L 1IGXA 2VJ3A 2J34B 2W3KB 1IOXA 3KK6A 3ZYIB 1EQGA 2W2PE 1FF7A 4X8TL 3LN1A 3HS5A 1P0SL 2K2SB 3NJPC 1IP0A 1IVOC 1PGEA 1M1XB 3OLTA 2KL7A 1NT0A 2M74A 2BZ6L 2Y7ZB 3GISX 3U73A 1HAFA 2RA0L 2D1JB 2EI6B 5CKQA 1EMNA 1COUA 3TGFA 5KN5C 3KCGL 4E1GA 2BOHA 3LN0A 3N8VA 3IITB 1CQEA 4ZAEB 2NPRA 3M37L 1FAXL 3TH3L 1F0RB 2J2UB 1KLJL 1ATDA 2W26B 3F1SB 2BOKL 1G1QA 2Y82B 2FLBL 1G1SA 2FLGA 4Y6DB 5L2YL 2P3TA 4BTUA 4JZEL 5IKRA 4ZXYL 2J38B 2VVCK 4BDWA 1DDXA 2WPKE 2P26A 3K9XA 1NFYB 2K2TA 2MHPA 3RR3A 2JKHL 2W86A 1CCVA 4BDXA 1NFXB 2RNLA 2VWLL 1EGFA 3GCWE 4RS0A 1EPJA 3KQEL 2BQ7A 4Y7BB 5EGMB 1PTHA 5JB9E 1G1TA 1APOA 2BMGA 1IOEL 1EAIC 3P5BL 3PGHA 4FM5A 2FLRL 4MMZB 3CS7L 4D90A 1FE2A 2W3IB 2XBVL 4D0EA 3FFGL 4JZFL 2Y7XB 2PHBB 2EI8B 3HS7A 1DQBA 3M36L 4RRWA 5JW1A 4OTYA 4X8UL 1JV2B 1Z6EL 2XBYL 1KSNB 2XBXL 5FDQA 1ATBA 3QCWA 2BQ6A 4COXA 3KL6B 1LMJA 1HRFA 1EZQB 1V3XB 3KQCL 2J4IB 1U8CB 1ADXA 5E8DA 1IQGL 2PUQL 1B9WA 2VH6B 2H9EC 1G1RA 1AUTL 2P3FN 2RHPA 4CUDA 1XKBA 4ZHAB 3N8XA 4PH9A 3SOVA 4NA9L 3SOBB 2YGPA 1ATAA 2PR3B 3DEMA 2CJIB 4YT6L 2KNIA 4A7IA 2DDUA 3Q7DA 1P9JA 1N7DA 4BXSA 3HO5A 1NZIA 4YT7L 2YGQA 1W8BL 2TGFA 2Q1JB 4RRZA 4X8SL 2KB9A 3KQDL 3V64C 3KRKA 1UZKA 3CA7A 2P93L 3LC5B 2KV4A 3SW2A 2WPME 2MGRA 3ZYGA 3V65B 2AYLA 1DVAL 1JBUL 2BOUA 2Y81B 1LMMA 1MQ6L 4MMYB 1KLIL 2Y80B 1F7EA 4M11A 1HT8A 4YZUB 5L30L 3N8YB 2XC5L 3Q3KB 5F19A 1UZQA 4O02B 3ENSA 2P16L 3S6XA 1HT5A 5L2ZL 1EPHA 1EPIA 4RRYA 4M10A 1FAKL 2WPLE 1X7AL 1ZAQA 3C9AC 1DIYA 4G1MB 2WG4B 1MOXC 1KLOA 1TLEA 1BF9A 1EMOA 3TK6B 3HO4A 1SZBA 1CEJA 3NT1A 4CSYA 1PXXA 3EGFA 3BT2A 3QH0A 5CISA 2G00L 1IQLL 1IQKL 2VWMK 3IJEB 3OLUA 1YUFA 4XBMA 3LIWB 1C5MF 1UZJA 1W7XL 2Y5GL 2Y5FL 1HZ8A 3N8WB 1PRHA 3F6UL 4JYVL 3CENL 1GK5A 1J9CL 2F9BL 1YUGA 1HJ7A 2P28B 6COXA 2GD4A 1G2LB 3N8WA 1UZPA 3MDLA 2UWOB 3N8ZA 4Y7AB 1XKAL 3GCXE 1I0UA 2W2NE 3R05A 5JBAE 1RFNB 3U7UG 4LMFA 4ZH8B 4BXWA 4C16A 1YO8A 1G2MB 4X8VL 2WFTA 2P94L 4NGAL 4RRXA 4NG9L 2VWNL 2VVVL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NQL B;  3LTG D;  1IQF L;  4Z6A L;  2P3U A;  2P3F L;  3N8Y A;  4JYU L;  2H9E L;  3ZYJ B;  2VH0 B;  1XFE A;  4O1Z A;  1NPE B;  1LQD A;  2I9A A;  2J95 B;  4OTJ A;  1A3P A;  1WHF A;  3QMO A;  4Y76 B;  2BO2 A;  1FSB A;  1LPK A;  4XL1 A;  4BTI A;  4CUF A;  4BTT A;  1N1I A;  1IJQ A;  2XC0 L;  3FCS B;  1WHE A;  1PFX L;  3H5C B;  3BT1 A;  2WFX B;  4ISI L;  5IKT A;  2UWP B;  1CCF A;  3LC3 B;  2UWL B;  2W2Q E;  2W2O E;  2WPH E;  1F7M A;  2XBW L;  3POY A;  1U67 A;  2WPI E;  1HX2 A;  5F1A A;  2FZZ L;  1IQH L;  2FD6 A;  1EBV A;  4D0F A;  2XC4 L;  2ADX A;  1L5G B;  5JBB E;  1L3Y A;  3NTB A;  2BQW A;  4ZXX L;  1IGZ A;  1IQJ L;  4Z0L A;  5KIR A;  2Y38 A;  5I46 L;  5JB8 E;  2I9B A;  2W2M E;  5JVZ A;  3HS6 A;  4ISH L;  2B7D L;  1IQN L;  2VWO L;  4Z0K B;  4AQT A;  1FJS L;  5IKQ A;  5K0H B;  4TGF A;  1LPG A;  3CFW A;  3TBD A;  1WU1 B;  1XDT R;  1MQ5 L;  3TZI A;  4CUE A;  1IQI L;  2OYE P;  2BOX A;  3SOQ A;  1F0S B;  1YUK B;  1KIG L;  1QFK L;  1HAE A;  3LAQ A;  2Y5H L;  1DX5 I;  5COX A;  1LPZ A;  1NFW B;  1YGC L;  3HO3 A;  1CVW L;  1HRE A;  1O5D L;  4JZD L;  5JBC E;  2WG3 C;  2YGO A;  1ATE A;  1TPG A;  2J94 B;  3FBY A;  4LOR A;  1OB1 C;  1Z6C A;  5CKM A;  2WYJ B;  2MGP A;  1HCG B;  1IQM L;  1CX2 A;  1Q4G A;  5JVY A;  5IKV A;  1FFM A;  1EQH A;  4RUT A;  1NFU B;  1APQ A;  1TOZ A;  3NTG A;  3MQE A;  4Y79 B;  3BPS E;  1EPG A;  2OYU P;  3ASI A;  4MMX B;  1K37 A;  5CKN A;  4Y71 B;  1JL9 A;  3LTF B;  1CVU A;  4XLW A;  2VVU L;  2WYG B;  3ELA L;  2WPJ E;  1URK A;  3KQB L;  3HPT A;  1K36 A;  3TK5 B;  1IQE L;  2EI7 B;  2P95 L;  1IGX A;  2VJ3 A;  2J34 B;  2W3K B;  1IOX A;  3KK6 A;  3ZYI B;  1EQG A;  2W2P E;  1FF7 A;  4X8T L;  3LN1 A;  3HS5 A;  1P0S L;  2K2S B;  3NJP C;  1IP0 A;  1IVO C;  1PGE A;  1M1X B;  3OLT A;  2KL7 A;  1NT0 A;  2M74 A;  2BZ6 L;  2Y7Z B;  3GIS X;  3U73 A;  1HAF A;  2RA0 L;  2D1J B;  2EI6 B;  5CKQ A;  1EMN A;  1COU A;  3TGF A;  5KN5 C;  3KCG L;  4E1G A;  2BOH A;  3LN0 A;  3N8V A;  3IIT B;  1CQE A;  4ZAE B;  2NPR A;  3M37 L;  1FAX L;  3TH3 L;  1F0R B;  2J2U B;  1KLJ L;  1ATD A;  2W26 B;  3F1S B;  2BOK L;  1G1Q A;  2Y82 B;  2FLB L;  1G1S A;  2FLG A;  4Y6D B;  5L2Y L;  2P3T A;  4BTU A;  4JZE L;  5IKR A;  4ZXY L;  2J38 B;  2VVC K;  4BDW A;  1DDX A;  2WPK E;  2P26 A;  3K9X A;  1NFY B;  2K2T A;  2MHP A;  3RR3 A;  2JKH L;  2W86 A;  1CCV A;  4BDX A;  1NFX B;  2RNL A;  2VWL L;  1EGF A;  3GCW E;  4RS0 A;  1EPJ A;  3KQE L;  2BQ7 A;  4Y7B B;  5EGM B;  1PTH A;  5JB9 E;  1G1T A;  1APO A;  2BMG A;  1IOE L;  1EAI C;  3P5B L;  3PGH A;  4FM5 A;  2FLR L;  4MMZ B;  3CS7 L;  4D90 A;  1FE2 A;  2W3I B;  2XBV L;  4D0E A;  3FFG L;  4JZF L;  2Y7X B;  2PHB B;  2EI8 B;  3HS7 A;  1DQB A;  3M36 L;  4RRW A;  5JW1 A;  4OTY A;  4X8U L;  1JV2 B;  1Z6E L;  2XBY L;  1KSN B;  2XBX L;  5FDQ A;  1ATB A;  3QCW A;  2BQ6 A;  4COX A;  3KL6 B;  1LMJ A;  1HRF A;  1EZQ B;  1V3X B;  3KQC L;  2J4I B;  1U8C B;  1ADX A;  5E8D A;  1IQG L;  2PUQ L;  1B9W A;  2VH6 B;  1G1R A;  1AUT L;  2P3F N;  2RHP A;  4CUD A;  1XKB A;  4ZHA B;  3N8X A;  4PH9 A;  3SOV A;  4NA9 L;  3SOB B;  2YGP A;  1ATA A;  2PR3 B;  3DEM A;  2CJI B;  4YT6 L;  4A7I A;  2DDU A;  3Q7D A;  1P9J A;  1N7D A;  4BXS A;  3HO5 A;  1NZI A;  4YT7 L;  1W8B L;  2TGF A;  2Q1J B;  4RRZ A;  4X8S L;  2KB9 A;  3KQD L;  3V64 C;  3KRK A;  1UZK A;  3CA7 A;  2P93 L;  3LC5 B;  2KV4 A;  3SW2 A;  2WPM E;  2MGR A;  3ZYG A;  3V65 B;  2AYL A;  1DVA L;  1JBU L;  2BOU A;  2Y81 B;  1MQ6 L;  4MMY B;  1KLI L;  2Y80 B;  1F7E A;  4M11 A;  1HT8 A;  4YZU B;  5L30 L;  3N8Y B;  2XC5 L;  3Q3K B;  5F19 A;  1UZQ A;  4O02 B;  3ENS A;  2P16 L;  1HT5 A;  5L2Z L;  1EPH A;  1EPI A;  4RRY A;  4M10 A;  1FAK L;  2WPL E;  1X7A L;  1ZAQ A;  3C9A C;  1DIY A;  4G1M B;  2WG4 B;  1MOX C;  1KLO A;  1TLE A;  1BF9 A;  1EMO A;  3TK6 B;  3HO4 A;  1SZB A;  1CEJ A;  3NT1 A;  4CSY A;  1PXX A;  3EGF A;  3BT2 A;  3QH0 A;  5CIS A;  2G00 L;  1IQL L;  1IQK L;  2VWM K;  3IJE B;  3OLU A;  1YUF A;  4XBM A;  3LIW B;  1C5M F;  1UZJ A;  1W7X L;  2Y5G L;  2Y5F L;  1HZ8 A;  3N8W B;  1PRH A;  3F6U L;  4JYV L;  3CEN L;  1GK5 A;  1J9C L;  2F9B L;  1YUG A;  1HJ7 A;  2P28 B;  6COX A;  2GD4 A;  1G2L B;  3N8W A;  1UZP A;  3MDL A;  2UWO B;  3N8Z A;  4Y7A B;  1XKA L;  3GCX E;  1I0U A;  2W2N E;  3R05 A;  5JBA E;  1RFN B;  3U7U G;  4LMF A;  4ZH8 B;  4BXW A;  4C16 A;  1YO8 A;  1G2M B;  4X8V L;  2WFT A;  2P94 L;  4NGA L;  4RRX A;  4NG9 L;  2VWN L;  2VVV L; 
#chains in the Genus database with same CATH topology
 1NQL B;  3LTG D;  1IQF L;  2VRS A;  4Z6A L;  2P3U A;  2P3F L;  3N8Y A;  4JYU L;  2H9E L;  3ZYJ B;  2VH0 B;  1XFE A;  4O1Z A;  1NPE B;  1LQD A;  2I9A A;  4A94 C;  2J95 B;  4OTJ A;  1A3P A;  1WHF A;  3QMO A;  4Y76 B;  2BO2 A;  1FSB A;  1LPK A;  4XL1 A;  4BTI A;  4CUF A;  4BTT A;  1N1I A;  1IJQ A;  2XC0 L;  3FCS B;  1WHE A;  1PFX L;  3H5C B;  3BT1 A;  2WFX B;  4ISI L;  5IKT A;  2UWP B;  1CCF A;  3LC3 B;  2UWL B;  2W2Q E;  2W2O E;  2WPH E;  1F7M A;  2XBW L;  3POY A;  1U67 A;  2WPI E;  1HX2 A;  5F1A A;  2FZZ L;  2JJL A;  1IQH L;  2FD6 A;  1EBV A;  4D0F A;  2XC4 L;  2ADX A;  1L5G B;  5JBB E;  1L3Y A;  3NTB A;  2BQW A;  4ZXX L;  1IGZ A;  1IQJ L;  4Z0L A;  5KIR A;  2Y38 A;  5I46 L;  5JB8 E;  2I9B A;  2W2M E;  5JVZ A;  3HS6 A;  4ISH L;  2B7D L;  1IQN L;  2VWO L;  4Z0K B;  4AQT A;  1FJS L;  5IKQ A;  5K0H B;  4TGF A;  1LPG A;  3CFW A;  3TBD A;  1LK9 A;  1WU1 B;  1XDT R;  1MQ5 L;  3TZI A;  4CUE A;  1IQI L;  2OYE P;  2BOX A;  3SOQ A;  1F0S B;  1YUK B;  1KIG L;  1QFK L;  1HAE A;  3LAQ A;  2Y5H L;  1DX5 I;  5COX A;  1LPZ A;  2HOR A;  1NFW B;  1YGC L;  3HO3 A;  1CVW L;  1HRE A;  1O5D L;  4JZD L;  5JBC E;  2WG3 C;  2YGO A;  1ATE A;  1TPG A;  2J94 B;  3FBY A;  4LOR A;  1OB1 C;  1Z6C A;  5CKM A;  2WYJ B;  2MGP A;  1HCG B;  1IQM L;  1CX2 A;  1Q4G A;  5JVY A;  5IKV A;  1FFM A;  2WZP P;  1EQH A;  4RUT A;  1NFU B;  1APQ A;  1TOZ A;  3NTG A;  3MQE A;  4Y79 B;  4GU3 A;  3BPS E;  1EPG A;  2OYU P;  3ASI A;  4MMX B;  1K37 A;  5CKN A;  4Y71 B;  1JL9 A;  3LTF B;  1CVU A;  4XLW A;  2VVU L;  2WYG B;  3ELA L;  2WPJ E;  1URK A;  3KQB L;  3HPT A;  1K36 A;  3TK5 B;  1IQE L;  2EI7 B;  2P95 L;  1IGX A;  2VJ3 A;  2J34 B;  2W3K B;  1IOX A;  3KK6 A;  3ZYI B;  1EQG A;  2W2P E;  1FF7 A;  1KKE A;  4X8T L;  3LN1 A;  3HS5 A;  1P0S L;  2K2S B;  3NJP C;  1IP0 A;  1IVO C;  1PGE A;  1M1X B;  3OLT A;  2KL7 A;  1NT0 A;  2M74 A;  2BZ6 L;  2Y7Z B;  3GIS X;  3U73 A;  1HAF A;  2RA0 L;  2D1J B;  2EI6 B;  5CKQ A;  1EMN A;  1COU A;  3TGF A;  5KN5 C;  3KCG L;  4E1G A;  2BOH A;  3LN0 A;  3N8V A;  3IIT B;  1CQE A;  2BT8 A;  4ZAE B;  2NPR A;  3M37 L;  1FAX L;  3TH3 L;  1F0R B;  2J2U B;  1KLJ L;  1ATD A;  2W26 B;  3F1S B;  2BOK L;  1G1Q A;  2Y82 B;  2FLB L;  1G1S A;  2FLG A;  4Y6D B;  5L2Y L;  2P3T A;  4BTU A;  4JZE L;  5IKR A;  4ZXY L;  2J38 B;  2VVC K;  4BDW A;  1DDX A;  2WPK E;  2P26 A;  3K9X A;  1NFY B;  2K2T A;  2MHP A;  3RR3 A;  2JKH L;  2W86 A;  1CCV A;  4BDX A;  1NFX B;  2RNL A;  2VWL L;  1EGF A;  3GCW E;  4RS0 A;  1EPJ A;  3KQE L;  2BQ7 A;  4Y7B B;  5EGM B;  1PTH A;  5JB9 E;  1G1T A;  1APO A;  2BMG A;  1IOE L;  1EAI C;  3P5B L;  3PGH A;  4FM5 A;  2FLR L;  4MMZ B;  3CS7 L;  4D90 A;  1FE2 A;  2W3I B;  2XBV L;  4D0E A;  3FFG L;  4JZF L;  2Y7X B;  2PHB B;  2EI8 B;  3HS7 A;  1DQB A;  3M36 L;  4RRW A;  5JW1 A;  4OTY A;  4X8U L;  1JV2 B;  1Z6E L;  2XBY L;  1KSN B;  2XBX L;  5FDQ A;  1ATB A;  3QCW A;  2BQ6 A;  4COX A;  3KL6 B;  1LMJ A;  1HRF A;  1EZQ B;  1V3X B;  3KQC L;  2J4I B;  1U8C B;  1ADX A;  5E8D A;  1IQG L;  2PUQ L;  1B9W A;  2VH6 B;  2H9E C;  1G1R A;  1V1I A;  1AUT L;  2P3F N;  2RHP A;  4CUD A;  1XKB A;  4ZHA B;  3N8X A;  4PH9 A;  3SOV A;  4NA9 L;  3SOB B;  2YGP A;  1ATA A;  2PR3 B;  3DEM A;  2CJI B;  4YT6 L;  2KNI A;  4A7I A;  2DDU A;  3Q7D A;  1P9J A;  1N7D A;  4BXS A;  3HO5 A;  1NZI A;  4YT7 L;  2YGQ A;  1W8B L;  2TGF A;  2Q1J B;  4RRZ A;  4X8S L;  2KB9 A;  3KQD L;  3V64 C;  3KRK A;  1QIU A;  1UZK A;  3CA7 A;  2P93 L;  2HOX A;  3LC5 B;  2BT7 A;  2KV4 A;  3SW2 A;  2WPM E;  2MGR A;  3ZYG A;  3V65 B;  2AYL A;  1DVA L;  1JBU L;  2BOU A;  2Y81 B;  1LMM A;  1MQ6 L;  4MMY B;  1KLI L;  2Y80 B;  4GU4 A;  4M11 A;  1F7E A;  1HT8 A;  4YZU B;  5L30 L;  3N8Y B;  2XC5 L;  3Q3K B;  5F19 A;  1UZQ A;  4O02 B;  3ENS A;  2P16 L;  3S6X A;  1HT5 A;  5L2Z L;  1EPH A;  1EPI A;  4RRY A;  4M10 A;  1FAK L;  2WPL E;  1X7A L;  1ZAQ A;  3C9A C;  1DIY A;  4G1M B;  2WG4 B;  1MOX C;  1KLO A;  2BSF A;  1TLE A;  1BF9 A;  1EMO A;  3TK6 B;  3HO4 A;  1SZB A;  1CEJ A;  3NT1 A;  4CSY A;  1PXX A;  3EGF A;  3BT2 A;  3QH0 A;  5CIS A;  2G00 L;  1IQL L;  1IQK L;  1V1H A;  2VWM K;  3IJE B;  3OLU A;  1YUF A;  4XBM A;  3LIW B;  1C5M F;  1UZJ A;  1W7X L;  2Y5G L;  2Y5F L;  1HZ8 A;  3N8W B;  1PRH A;  3F6U L;  4JYV L;  3CEN L;  1GK5 A;  1J9C L;  2F9B L;  1YUG A;  1HJ7 A;  2P28 B;  6COX A;  2GD4 A;  1G2L B;  3N8W A;  1UZP A;  3MDL A;  2UWO B;  3N8Z A;  4Y7A B;  1XKA L;  3GCX E;  1I0U A;  2W2N E;  3R05 A;  5JBA E;  1RFN B;  3U7U G;  4LMF A;  4ZH8 B;  4BXW A;  4C16 A;  1YO8 A;  1G2M B;  4X8V L;  2WFT A;  2P94 L;  4NGA L;  4RRX A;  4NG9 L;  2VWN L;  2VVV L; 
#chains in the Genus database with same CATH homology
 1NQL B;  3LTG D;  1IQF L;  4Z6A L;  2P3U A;  2P3F L;  3N8Y A;  4JYU L;  2H9E L;  3ZYJ B;  2VH0 B;  1XFE A;  4O1Z A;  1NPE B;  1LQD A;  2I9A A;  4A94 C;  2J95 B;  4OTJ A;  1A3P A;  1WHF A;  3QMO A;  4Y76 B;  2BO2 A;  1FSB A;  1LPK A;  4XL1 A;  4BTI A;  4CUF A;  4BTT A;  1N1I A;  1IJQ A;  2XC0 L;  3FCS B;  1WHE A;  1PFX L;  3H5C B;  3BT1 A;  2WFX B;  4ISI L;  5IKT A;  2UWP B;  1CCF A;  3LC3 B;  2UWL B;  2W2Q E;  2W2O E;  2WPH E;  1F7M A;  2XBW L;  3POY A;  1U67 A;  2WPI E;  1HX2 A;  5F1A A;  2FZZ L;  1IQH L;  2FD6 A;  1EBV A;  4D0F A;  2XC4 L;  2ADX A;  1L5G B;  5JBB E;  1L3Y A;  3NTB A;  2BQW A;  4ZXX L;  1IGZ A;  1IQJ L;  4Z0L A;  5KIR A;  2Y38 A;  5I46 L;  5JB8 E;  2I9B A;  2W2M E;  5JVZ A;  3HS6 A;  4ISH L;  2B7D L;  1IQN L;  2VWO L;  4Z0K B;  4AQT A;  1FJS L;  5IKQ A;  5K0H B;  4TGF A;  1LPG A;  3CFW A;  3TBD A;  1WU1 B;  1XDT R;  1MQ5 L;  3TZI A;  4CUE A;  1IQI L;  2OYE P;  2BOX A;  3SOQ A;  1F0S B;  1YUK B;  1KIG L;  1QFK L;  1HAE A;  3LAQ A;  2Y5H L;  1DX5 I;  5COX A;  1LPZ A;  1NFW B;  1YGC L;  3HO3 A;  1CVW L;  1HRE A;  1O5D L;  4JZD L;  5JBC E;  2WG3 C;  2YGO A;  1ATE A;  1TPG A;  2J94 B;  3FBY A;  4LOR A;  1OB1 C;  1Z6C A;  5CKM A;  2WYJ B;  2MGP A;  1HCG B;  1IQM L;  1CX2 A;  1Q4G A;  5JVY A;  5IKV A;  1FFM A;  2WZP P;  1EQH A;  4RUT A;  1NFU B;  1APQ A;  1TOZ A;  3NTG A;  3MQE A;  4Y79 B;  3BPS E;  1EPG A;  2OYU P;  3ASI A;  4MMX B;  1K37 A;  5CKN A;  4Y71 B;  1JL9 A;  3LTF B;  1CVU A;  4XLW A;  2VVU L;  2WYG B;  3ELA L;  2WPJ E;  1URK A;  3KQB L;  3HPT A;  1K36 A;  3TK5 B;  1IQE L;  2EI7 B;  2P95 L;  1IGX A;  2VJ3 A;  2J34 B;  2W3K B;  1IOX A;  3KK6 A;  3ZYI B;  1EQG A;  2W2P E;  1FF7 A;  4X8T L;  3LN1 A;  3HS5 A;  1P0S L;  2K2S B;  3NJP C;  1IP0 A;  1IVO C;  1PGE A;  1M1X B;  3OLT A;  2KL7 A;  1NT0 A;  2M74 A;  2BZ6 L;  2Y7Z B;  3GIS X;  3U73 A;  1HAF A;  2RA0 L;  2D1J B;  2EI6 B;  5CKQ A;  1EMN A;  1COU A;  3TGF A;  5KN5 C;  3KCG L;  4E1G A;  2BOH A;  3LN0 A;  3N8V A;  3IIT B;  1CQE A;  4ZAE B;  2NPR A;  3M37 L;  1FAX L;  3TH3 L;  1F0R B;  2J2U B;  1KLJ L;  1ATD A;  2W26 B;  3F1S B;  2BOK L;  1G1Q A;  2Y82 B;  2FLB L;  1G1S A;  2FLG A;  4Y6D B;  5L2Y L;  2P3T A;  4BTU A;  4JZE L;  5IKR A;  4ZXY L;  2J38 B;  2VVC K;  4BDW A;  1DDX A;  2WPK E;  2P26 A;  3K9X A;  1NFY B;  2K2T A;  2MHP A;  3RR3 A;  2JKH L;  2W86 A;  1CCV A;  4BDX A;  1NFX B;  2RNL A;  2VWL L;  1EGF A;  3GCW E;  4RS0 A;  1EPJ A;  3KQE L;  2BQ7 A;  4Y7B B;  5EGM B;  1PTH A;  5JB9 E;  1G1T A;  1APO A;  2BMG A;  1IOE L;  1EAI C;  3P5B L;  3PGH A;  4FM5 A;  2FLR L;  4MMZ B;  3CS7 L;  4D90 A;  1FE2 A;  2W3I B;  2XBV L;  4D0E A;  3FFG L;  4JZF L;  2Y7X B;  2PHB B;  2EI8 B;  3HS7 A;  1DQB A;  3M36 L;  4RRW A;  5JW1 A;  4OTY A;  4X8U L;  1JV2 B;  1Z6E L;  2XBY L;  1KSN B;  2XBX L;  5FDQ A;  1ATB A;  3QCW A;  2BQ6 A;  4COX A;  3KL6 B;  1LMJ A;  1HRF A;  1EZQ B;  1V3X B;  3KQC L;  2J4I B;  1U8C B;  1ADX A;  5E8D A;  1IQG L;  2PUQ L;  1B9W A;  2VH6 B;  2H9E C;  1G1R A;  1AUT L;  2P3F N;  2RHP A;  4CUD A;  1XKB A;  4ZHA B;  3N8X A;  4PH9 A;  3SOV A;  4NA9 L;  3SOB B;  2YGP A;  1ATA A;  2PR3 B;  3DEM A;  2CJI B;  4YT6 L;  2KNI A;  4A7I A;  2DDU A;  3Q7D A;  1P9J A;  1N7D A;  4BXS A;  3HO5 A;  1NZI A;  4YT7 L;  2YGQ A;  1W8B L;  2TGF A;  2Q1J B;  4RRZ A;  4X8S L;  2KB9 A;  3KQD L;  3V64 C;  3KRK A;  1UZK A;  3CA7 A;  2P93 L;  3LC5 B;  2KV4 A;  3SW2 A;  2WPM E;  2MGR A;  3ZYG A;  3V65 B;  2AYL A;  1DVA L;  1JBU L;  2BOU A;  2Y81 B;  1LMM A;  1MQ6 L;  4MMY B;  1KLI L;  2Y80 B;  1F7E A;  4M11 A;  1HT8 A;  4YZU B;  5L30 L;  3N8Y B;  2XC5 L;  3Q3K B;  5F19 A;  1UZQ A;  4O02 B;  3ENS A;  2P16 L;  3S6X A;  1HT5 A;  5L2Z L;  1EPH A;  1EPI A;  4RRY A;  4M10 A;  1FAK L;  2WPL E;  1X7A L;  1ZAQ A;  3C9A C;  1DIY A;  4G1M B;  2WG4 B;  1MOX C;  1KLO A;  1TLE A;  1BF9 A;  1EMO A;  3TK6 B;  3HO4 A;  1SZB A;  1CEJ A;  3NT1 A;  4CSY A;  1PXX A;  3EGF A;  3BT2 A;  3QH0 A;  5CIS A;  2G00 L;  1IQL L;  1IQK L;  2VWM K;  3IJE B;  3OLU A;  1YUF A;  4XBM A;  3LIW B;  1C5M F;  1UZJ A;  1W7X L;  2Y5G L;  2Y5F L;  1HZ8 A;  3N8W B;  1PRH A;  3F6U L;  4JYV L;  3CEN L;  1GK5 A;  1J9C L;  2F9B L;  1YUG A;  1HJ7 A;  2P28 B;  6COX A;  2GD4 A;  1G2L B;  3N8W A;  1UZP A;  3MDL A;  2UWO B;  3N8Z A;  4Y7A B;  1XKA L;  3GCX E;  1I0U A;  2W2N E;  3R05 A;  5JBA E;  1RFN B;  3U7U G;  4LMF A;  4ZH8 B;  4BXW A;  4C16 A;  1YO8 A;  1G2M B;  4X8V L;  2WFT A;  2P94 L;  4NGA L;  4RRX A;  4NG9 L;  2VWN L;  2VVV L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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