3KMEA

Crystal structure of catalytic domain of tace with phenyl-pyrrolidinyl-tartrate inhibitor
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
257
structure length
253
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords TNF-alpha-converting enzyme
publication title The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 80
structure length 253
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2009-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3kmeA00
1KUHA 4WKEA 3EDZA 1RMZA 1EAKA 4WF6A 1QIAA 1EB6A 4H76A 3LEAA 1I1IP 1OM8A 4GR8A 1CGEA 4I03A 1UMSA 1J7NA 4WK7A 1JH1A 1XFWA 1GE5A 2D1OA 1C8TA 1BKCA 2W0DA 5B5PA 3WV3A 1Y0VA 4DPEA 4WKIA 1SRPA 1FLSA 4AIGA 3F18A 1IAEA 3LUMA 3TVCA 4JP4A 1BZSA 1UEAA 1MMPA 1ZXVA 2Z2DA 2FV9A 1CGLA 1JJ9A 4AYKA 3DPEA 1QICA 1XUCA 1H71P 2W15A 5I4OA 3DPFA 1A86A 3OHOA 1R1JA 1G4KA 3OHLA 3MA2A 3VI1A 5I0LA 1PWWA 4A3WA 1HV5A 2DDYA 4ILWD 2Y6CA 1KUKA 3LE9A 3DNGA 1O0QA 1USNA 3F16A 1BIWA 2J83A 3O64A 1IACA 3F1AA 4DV8A 2JT5A 5BPAA 4JIJA 1BQOA 2MLSA 4H30A 4QKZA 2USNA 2JSDA 4DD8A 1JKYA 3N2UA 4AUOA 2MLRA 4Q1LA 2OY2A 1IABA 1PWUA 1C7KA 3HBVP 4XM8A 4CTHA 1R1IA 1HFCA 2DDFA 5L7FA 2OVXA 2W13A 1ZP5A 4XM7A 3USNA 3ZXHA 3CKIA 1R1HA 2O36A 1IAGA 2W12A 1ZXCA 3LUNA 4ZR5A 4GWNA 4PKVA 5D7WA 1KUGA 4GQLA 4A7BA 1FBLA 2QPJA 2X3AA 1JK3A 1BKCI 1GO7P 4JA1A 2DW1A 1D8FA 1B3DA 5I3MA 3VTGA 1BUVM 3LJTA 2CLTA 1HTDA 3K7NA 3V96B 4PKUA 1WNIA 2D1NA 1KAPP 3LGPA 1PWPA 4IN9A 1YOUA 1R55A 4H84A 3BA0A 5L79A 1D5JA 1G05A 1EUBA 2L0RA 2WO9A 4XBHA 5D1SA 5CUHA 1JAOA 4L63A 3HDBA 5H8XA 1MMRA 4PKRA 2OW0A 2MZIA 1YCMA 5I12A 3F15A 1JAQA 1OO9A 4DF9A 4FU4A 1HOVA 4FXYP 1XFZA 2CKIA 5JMYA 3LJZA 1XFYA 1D7XA 3AYKA 1XUDA 1KUFA 3ZUKA 4G0DA 2JNPA 3HY7A 1K7QA 4PKQA 5CZMA 1UTZA 2OZRA 1AKLA 3KEKA 2DW2A 1GKCA 2Y6DA 3TT4A 3LILA 3B2ZA 4H3XA 2ERPA 3KEJA 3DWBA 2PJTA 2K2GA 1QUAA 2OW9A 3Q2GA 1K7IA 3KWVC 1SLMA 3LQBA 2E3XA 3U1RA 3SHIA 1CGFA 2X7MA 1KBCA 4L6TA 3LQ0A 1SU3A 1IADA 3HDAP 1G9KA 5B5OA 1JAPA 5LABA 2OW2A 3E8RA 2POJA 2X3BA 3KMCA 1G49A 3EHXA 2DW0A 3ELMA 2I47A 1JANA 3RTTA 2OW1A 5D2BA 3HBUP 1XFXA 1XURA 3L0VA 1ATLA 3LK8A 4WZVA 1AYKA 3KMEA 1XFUA 2RJQA 4H2EA 3LIRA 1GKDA 4R3VA 3WV1A 1S4BP 2FV5A 3B8ZA 2E2DA 2ERQA 4PKSA 1OMJA 1C3IA 1HFSA 2K9CA 4IJOA 2HU6A 4FVLA 5D1TA 2YB9A 2OXWA 4XM6A 3Q2HA 1UMTA 1ZVXA 2MZEA 5CXAA 4GWMA 4PKTA 5D3CA 2A8HA 3L0TA 1O0TA 5BOTA 966CA 3LJGA 1RM8A 2MZHA 1YQYA 3B92A 1OS2A 2TCLA 1D8MA 4GUYA 2YIGA 1ROSA 5D1UA 1UTTA 4HX3A 3AYUA 1CK7A 4H82A 1CIZA 4GF1A 1BKCE 1SATA 1QJIA 3EWJA 2OY4A 1B8YA 2WOAA 4J4MA 2V4BA 2WO8A 4HMAA 1JIZA 2XS3A 1Y93A 3N2VA 3HY9A 2JIHA 1BQQM 1GO8P 2O3EA 2AYKA 3EHYA 1PWQA 1L6JA 2EROA 3TS4A 1KUIA 2XS4A 4EFSA 4GR3A 3GBOA 1FM1A 3LKAA 1Z3JA 1MMQA 3I7IA 1Y8JA 1PWVA 5I2ZA 1MNCA 3DSLA 4PKWA 4L19A 4GR0A 1QJJA 2OXZA 2N8RA 4JQGA 1BSWA 1ZTQA 1OS9A 2W14A 3TSKA 1QIBA 1Q3AA 1R54A 2X3CA 1SMPA 2J0TA 3NX7A 3RTSA 3G42A 4AXQA 4JPAA 1OM7A 2OI0A 4I35A 3WV2A 1AF0A 1GXDA 1IAAA 5BOYA 3F19A 1CXVA 1MMBA 3LMCA 3F17A 4G9LA 3K7LA 3LIKA 4H1QA 1DTHA 3HYGA 1A85A 3UVCA 1DMTA 4H49A 1OM6A 3G5CA 4XCTA 1I73A 1BUDA 3EDIA 1ZS0A 830CA 1GE7A 1XFVA 1ND1A 5I43A 4FXQA 2RJPA 3P24A 3KHIA 3KECA 3ZVSA 1BM6A 1CQRA 2SRTA 4IUWA 3AIGA 3P1VA 1SLNA 1G12A 2KRJA 1CAQA 1ASTA 1JIWP 1K7GA 3O2XA 1I76A 3EDHA 3I7GA 3KRYA 4ON1A 1GE6A 3DL1A 2OVZA 2AIGP 1YP1A 3EDGA 3HB2P 456CA 1HY7A 2OXUA 2JT6A
chains in the Genus database with same CATH superfamily
1KUHA 4WKEA 3EDZA 1RMZA 1EAKA 4WF6A 1QIAA 1EB6A 4H76A 3LEAA 1I1IP 1OM8A 4GR8A 1CGEA 4I03A 1UMSA 1J7NA 4WK7A 1JH1A 1XFWA 1GE5A 2D1OA 1C8TA 1BKCA 2W0DA 5B5PA 3WV3A 1Y0VA 4DPEA 4WKIA 1SRPA 1FLSA 4AIGA 3F18A 1IAEA 3LUMA 3TVCA 4JP4A 1BZSA 1UEAA 1MMPA 1ZXVA 2Z2DA 2FV9A 1CGLA 1JJ9A 4AYKA 3DPEA 1QICA 1XUCA 1H71P 2W15A 5I4OA 3DPFA 1A86A 3OHOA 1R1JA 1G4KA 3OHLA 3MA2A 3VI1A 5I0LA 1PWWA 4A3WA 1HV5A 2DDYA 4ILWD 2Y6CA 1KUKA 3LE9A 3DNGA 1O0QA 1USNA 3F16A 1BIWA 2J83A 3O64A 1IACA 3F1AA 4DV8A 2JT5A 5BPAA 4JIJA 1BQOA 2MLSA 4H30A 4QKZA 2USNA 2JSDA 4DD8A 1JKYA 3N2UA 4AUOA 2MLRA 4Q1LA 2OY2A 1IABA 1PWUA 1C7KA 3HBVP 4XM8A 4CTHA 1R1IA 1HFCA 2DDFA 5L7FA 2OVXA 2W13A 1ZP5A 4XM7A 3USNA 3ZXHA 3CKIA 1R1HA 2O36A 1IAGA 2W12A 1ZXCA 3LUNA 4ZR5A 4GWNA 4PKVA 5D7WA 1KUGA 4GQLA 4A7BA 1FBLA 2QPJA 2X3AA 1JK3A 1BKCI 1GO7P 4JA1A 2DW1A 1D8FA 1B3DA 5I3MA 3VTGA 1BUVM 3LJTA 2CLTA 1HTDA 3K7NA 3V96B 4PKUA 1WNIA 2D1NA 1KAPP 3LGPA 1PWPA 4IN9A 1YOUA 1R55A 4H84A 3BA0A 5L79A 1D5JA 1G05A 1EUBA 2L0RA 2WO9A 4XBHA 5D1SA 5CUHA 1JAOA 4L63A 3HDBA 5H8XA 1MMRA 4PKRA 2OW0A 2MZIA 1YCMA 5I12A 3F15A 1JAQA 1OO9A 4DF9A 4FU4A 1HOVA 4FXYP 1XFZA 2CKIA 5JMYA 3LJZA 1XFYA 1D7XA 3AYKA 1XUDA 1KUFA 3ZUKA 4G0DA 2JNPA 3HY7A 1K7QA 4PKQA 5CZMA 1UTZA 2OZRA 1AKLA 3KEKA 2DW2A 1GKCA 2Y6DA 3TT4A 3LILA 3B2ZA 4H3XA 2ERPA 3KEJA 3DWBA 2PJTA 2K2GA 1QUAA 2OW9A 3Q2GA 1K7IA 3KWVC 1SLMA 3LQBA 2E3XA 3U1RA 3SHIA 1CGFA 1XM5A 2X7MA 1KBCA 4L6TA 3LQ0A 1SU3A 1IADA 3HDAP 1G9KA 5B5OA 1JAPA 1XAXA 5LABA 4L7AA 2OW2A 3E8RA 2POJA 2X3BA 3KMCA 1G49A 3EHXA 2DW0A 3ELMA 2I47A 1JANA 3RTTA 2OW1A 5D2BA 3HBUP 1XFXA 1XURA 3L0VA 1ATLA 3LK8A 4WZVA 1AYKA 3KMEA 1XFUA 2RJQA 4H2EA 3LIRA 1GKDA 4R3VA 3WV1A 1S4BP 2FV5A 3B8ZA 2E2DA 2ERQA 4PKSA 1OMJA 1C3IA 1HFSA 2K9CA 4IJOA 2HU6A 4FVLA 5D1TA 2YB9A 2OXWA 4XM6A 3Q2HA 1UMTA 1ZVXA 2MZEA 5CXAA 4GWMA 4PKTA 5D3CA 2A8HA 3L0TA 1O0TA 5BOTA 966CA 3LJGA 1RM8A 2MZHA 1YQYA 3B92A 1OS2A 2TCLA 1D8MA 4GUYA 2YIGA 1ROSA 5D1UA 1UTTA 4HX3A 3AYUA 1CK7A 4H82A 1CIZA 4GF1A 1BKCE 1SATA 1QJIA 3EWJA 2OY4A 1B8YA 2WOAA 4J4MA 2V4BA 2WO8A 4HMAA 1JIZA 2XS3A 1Y93A 3N2VA 3HY9A 2JIHA 1BQQM 1GO8P 2O3EA 2AYKA 3EHYA 1PWQA 1L6JA 2EROA 3TS4A 1KUIA 2XS4A 4EFSA 4GR3A 3GBOA 1FM1A 3LKAA 1Z3JA 2YUFA 1MMQA 3I7IA 1Y8JA 1PWVA 5I2ZA 1MNCA 3DSLA 4PKWA 4L19A 4GR0A 1QJJA 2OXZA 2N8RA 4JQGA 1BSWA 3DTKA 1TVIA 1ZTQA 3DTEA 1OS9A 2W14A 3TSKA 1QIBA 1Q3AA 1R54A 2X3CA 1SMPA 2J0TA 3NX7A 3RTSA 3G42A 4AXQA 4JPAA 1OM7A 2OI0A 4I35A 3WV2A 1AF0A 1GXDA 1IAAA 5BOYA 3F19A 1CXVA 1MMBA 3LMCA 3F17A 4G9LA 3K7LA 3LIKA 4H1QA 1DTHA 3HYGA 1A85A 3UVCA 1OZ9A 1DMTA 4H49A 1OM6A 3G5CA 4XCTA 1I73A 1BUDA 3EDIA 1ZS0A 830CA 1GE7A 1XFVA 1ND1A 5I43A 4FXQA 2RJPA 3P24A 3KHIA 3KECA 3ZVSA 1BM6A 1CQRA 2SRTA 4IUWA 3AIGA 3P1VA 1SLNA 1G12A 2KRJA 1CAQA 1ASTA 1JIWP 1K7GA 3O2XA 1I76A 3EDHA 3I7GA 3KRYA 4ON1A 1GE6A 3DL1A 3DTIA 2OVZA 2AIGP 1YP1A 3EDGA 3HB2P 456CA 1HY7A 2OXUA 2JT6A
chains in the Genus database with same CATH topology
1KUHA 4WKEA 3EDZA 1RMZA 1EAKA 4WF6A 1QIAA 1EB6A 4H76A 3LEAA 1I1IP 1OM8A 4GR8A 1CGEA 4I03A 1UMSA 1J7NA 4WK7A 1JH1A 1XFWA 1GE5A 2D1OA 1C8TA 1BKCA 2W0DA 5B5PA 3WV3A 1Y0VA 4DPEA 4WKIA 1SRPA 1FLSA 4AIGA 3F18A 1IAEA 3LUMA 3TVCA 4JP4A 1BZSA 1UEAA 1MMPA 1ZXVA 2Z2DA 2FV9A 1CGLA 1JJ9A 4AYKA 3DPEA 1QICA 1XUCA 1H71P 2W15A 5I4OA 3DPFA 1A86A 3OHOA 1R1JA 1G4KA 3OHLA 3MA2A 3VI1A 5I0LA 1PWWA 4A3WA 1HV5A 2DDYA 4ILWD 2Y6CA 1KUKA 3LE9A 3DNGA 1O0QA 1USNA 3F16A 1BIWA 2J83A 3O64A 1IACA 3F1AA 4DV8A 2JT5A 5BPAA 4JIJA 1BQOA 2MLSA 4H30A 4QKZA 2USNA 2JSDA 4DD8A 1JKYA 3N2UA 4AUOA 2MLRA 4Q1LA 2OY2A 1IABA 1PWUA 1C7KA 3HBVP 4XM8A 4CTHA 1R1IA 1HFCA 2DDFA 5L7FA 2OVXA 2W13A 1ZP5A 4XM7A 3USNA 3ZXHA 3CKIA 1R1HA 2O36A 1IAGA 2W12A 1ZXCA 3LUNA 4ZR5A 4GWNA 4PKVA 5D7WA 1KUGA 4GQLA 4A7BA 1FBLA 2QPJA 2X3AA 1JK3A 1BKCI 1GO7P 4JA1A 2DW1A 1D8FA 1B3DA 5I3MA 3VTGA 1BUVM 3LJTA 2CLTA 1HTDA 3K7NA 3V96B 4PKUA 1WNIA 2D1NA 1KAPP 3LGPA 1PWPA 4IN9A 1YOUA 1R55A 4H84A 3BA0A 5L79A 1D5JA 1G05A 1EUBA 2L0RA 2WO9A 4XBHA 5D1SA 5CUHA 1JAOA 4L63A 3HDBA 5H8XA 1MMRA 4PKRA 2OW0A 2MZIA 1YCMA 5I12A 3F15A 1JAQA 1OO9A 4DF9A 4FU4A 1HOVA 4FXYP 1XFZA 2CKIA 5JMYA 3LJZA 1XFYA 1D7XA 3AYKA 1XUDA 1KUFA 3ZUKA 4G0DA 2JNPA 3HY7A 1K7QA 4PKQA 5CZMA 1UTZA 2OZRA 1AKLA 3KEKA 2DW2A 1GKCA 2Y6DA 3TT4A 3LILA 3B2ZA 4H3XA 2ERPA 3KEJA 3DWBA 2PJTA 2K2GA 1QUAA 2OW9A 3Q2GA 1K7IA 3KWVC 1SLMA 3LQBA 2E3XA 3U1RA 3SHIA 1CGFA 2X7MA 1KBCA 4L6TA 3LQ0A 1SU3A 1IADA 3HDAP 1G9KA 5B5OA 1JAPA 5LABA 4L7AA 2OW2A 3E8RA 2POJA 2X3BA 3KMCA 1G49A 3EHXA 2DW0A 3ELMA 2I47A 1JANA 3RTTA 2OW1A 5D2BA 3HBUP 1XFXA 1XURA 3L0VA 1ATLA 3LK8A 4WZVA 1AYKA 3KMEA 1XFUA 2RJQA 4H2EA 3LIRA 1GKDA 4R3VA 3WV1A 1S4BP 2FV5A 3B8ZA 2E2DA 2ERQA 4PKSA 1OMJA 1C3IA 1HFSA 2K9CA 4IJOA 2HU6A 4FVLA 5D1TA 2YB9A 2OXWA 4XM6A 3Q2HA 1UMTA 1ZVXA 2MZEA 5CXAA 4GWMA 4PKTA 5D3CA 2A8HA 3L0TA 1O0TA 5BOTA 966CA 3LJGA 1RM8A 2MZHA 1YQYA 3B92A 1OS2A 2TCLA 1D8MA 4GUYA 2YIGA 1ROSA 5D1UA 1UTTA 4HX3A 3AYUA 1CK7A 4H82A 1CIZA 4GF1A 1BKCE 1SATA 1QJIA 3EWJA 2OY4A 1B8YA 2WOAA 4J4MA 2V4BA 2WO8A 4HMAA 1JIZA 2XS3A 1Y93A 3N2VA 3HY9A 2JIHA 1BQQM 1GO8P 2O3EA 2AYKA 3EHYA 1PWQA 1L6JA 2EROA 3TS4A 1KUIA 2XS4A 4EFSA 4GR3A 3GBOA 1FM1A 3LKAA 1Z3JA 2YUFA 1MMQA 3I7IA 1Y8JA 1PWVA 5I2ZA 1MNCA 3DSLA 4PKWA 4L19A 4GR0A 1QJJA 2OXZA 2N8RA 4JQGA 1BSWA 3DTKA 1ZTQA 3DTEA 1OS9A 2W14A 3TSKA 1QIBA 1Q3AA 1R54A 2X3CA 1SMPA 2J0TA 3NX7A 3RTSA 3G42A 4AXQA 4JPAA 1OM7A 2OI0A 4I35A 3WV2A 1AF0A 1GXDA 1IAAA 5BOYA 3F19A 1CXVA 1MMBA 3LMCA 3F17A 4G9LA 3K7LA 3LIKA 4H1QA 1DTHA 3HYGA 1A85A 3UVCA 1DMTA 4H49A 1OM6A 3G5CA 4XCTA 1I73A 1BUDA 3EDIA 1ZS0A 830CA 1GE7A 1XFVA 1ND1A 5I43A 4FXQA 2RJPA 3P24A 3KHIA 3KECA 3ZVSA 1BM6A 1CQRA 2SRTA 4IUWA 3AIGA 3P1VA 1SLNA 1G12A 2KRJA 1CAQA 1ASTA 1JIWP 1K7GA 3O2XA 1I76A 3EDHA 3I7GA 3KRYA 4ON1A 1GE6A 3DL1A 3DTIA 2OVZA 2AIGP 1YP1A 3EDGA 3HB2P 456CA 1HY7A 2OXUA 2JT6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KUH A;  4WKE A;  3EDZ A;  1RMZ A;  1EAK A;  4WF6 A;  1QIA A;  1EB6 A;  4H76 A;  3LEA A;  1I1I P;  1OM8 A;  4GR8 A;  1CGE A;  4I03 A;  1UMS A;  1J7N A;  4WK7 A;  1JH1 A;  1XFW A;  1GE5 A;  2D1O A;  1C8T A;  1BKC A;  2W0D A;  5B5P A;  3WV3 A;  1Y0V A;  4DPE A;  4WKI A;  1SRP A;  1FLS A;  4AIG A;  3F18 A;  1IAE A;  3LUM A;  3TVC A;  4JP4 A;  1BZS A;  1UEA A;  1MMP A;  1ZXV A;  2Z2D A;  2FV9 A;  1CGL A;  1JJ9 A;  4AYK A;  3DPE A;  1QIC A;  1XUC A;  1H71 P;  2W15 A;  5I4O A;  3DPF A;  1A86 A;  3OHO A;  1R1J A;  1G4K A;  3OHL A;  3MA2 A;  3VI1 A;  5I0L A;  1PWW A;  4A3W A;  1HV5 A;  2DDY A;  4ILW D;  2Y6C A;  1KUK A;  3LE9 A;  3DNG A;  1O0Q A;  1USN A;  3F16 A;  1BIW A;  2J83 A;  3O64 A;  1IAC A;  3F1A A;  4DV8 A;  2JT5 A;  5BPA A;  4JIJ A;  1BQO A;  2MLS A;  4H30 A;  4QKZ A;  2USN A;  2JSD A;  4DD8 A;  1JKY A;  3N2U A;  4AUO A;  2MLR A;  4Q1L A;  2OY2 A;  1IAB A;  1PWU A;  1C7K A;  3HBV P;  4XM8 A;  4CTH A;  1R1I A;  1HFC A;  2DDF A;  5L7F A;  2OVX A;  2W13 A;  1ZP5 A;  4XM7 A;  3USN A;  3ZXH A;  3CKI A;  1R1H A;  2O36 A;  1IAG A;  2W12 A;  1ZXC A;  3LUN A;  4ZR5 A;  4GWN A;  4PKV A;  5D7W A;  1KUG A;  4GQL A;  4A7B A;  1FBL A;  2QPJ A;  2X3A A;  1JK3 A;  1BKC I;  1GO7 P;  4JA1 A;  2DW1 A;  1D8F A;  1B3D A;  5I3M A;  3VTG A;  1BUV M;  3LJT A;  2CLT A;  1HTD A;  3K7N A;  3V96 B;  4PKU A;  1WNI A;  2D1N A;  1KAP P;  3LGP A;  1PWP A;  4IN9 A;  1YOU A;  1R55 A;  4H84 A;  3BA0 A;  5L79 A;  1D5J A;  1G05 A;  1EUB A;  2L0R A;  2WO9 A;  4XBH A;  5D1S A;  5CUH A;  1JAO A;  4L63 A;  3HDB A;  5H8X A;  1MMR A;  4PKR A;  2OW0 A;  2MZI A;  1YCM A;  5I12 A;  3F15 A;  1JAQ A;  1OO9 A;  4DF9 A;  4FU4 A;  1HOV A;  4FXY P;  1XFZ A;  2CKI A;  5JMY A;  3LJZ A;  1XFY A;  1D7X A;  3AYK A;  1XUD A;  1KUF A;  3ZUK A;  4G0D A;  2JNP A;  3HY7 A;  1K7Q A;  4PKQ A;  5CZM A;  1UTZ A;  2OZR A;  1AKL A;  3KEK A;  2DW2 A;  1GKC A;  2Y6D A;  3TT4 A;  3LIL A;  3B2Z A;  4H3X A;  2ERP A;  3KEJ A;  3DWB A;  2PJT A;  2K2G A;  1QUA A;  2OW9 A;  3Q2G A;  1K7I A;  3KWV C;  1SLM A;  3LQB A;  2E3X A;  3U1R A;  3SHI A;  1CGF A;  2X7M A;  1KBC A;  4L6T A;  3LQ0 A;  1SU3 A;  1IAD A;  3HDA P;  1G9K A;  5B5O A;  1JAP A;  5LAB A;  2OW2 A;  3E8R A;  2POJ A;  2X3B A;  3KMC A;  1G49 A;  3EHX A;  2DW0 A;  3ELM A;  2I47 A;  1JAN A;  3RTT A;  2OW1 A;  5D2B A;  3HBU P;  1XFX A;  1XUR A;  3L0V A;  1ATL A;  3LK8 A;  4WZV A;  1AYK A;  3KME A;  1XFU A;  2RJQ A;  4H2E A;  3LIR A;  1GKD A;  4R3V A;  3WV1 A;  1S4B P;  2FV5 A;  3B8Z A;  2E2D A;  2ERQ A;  4PKS A;  1OMJ A;  1C3I A;  1HFS A;  2K9C A;  4IJO A;  2HU6 A;  4FVL A;  5D1T A;  2YB9 A;  2OXW A;  4XM6 A;  3Q2H A;  1UMT A;  1ZVX A;  2MZE A;  5CXA A;  4GWM A;  4PKT A;  5D3C A;  2A8H A;  3L0T A;  1O0T A;  5BOT A;  966C A;  3LJG A;  1RM8 A;  2MZH A;  1YQY A;  3B92 A;  1OS2 A;  2TCL A;  1D8M A;  4GUY A;  2YIG A;  1ROS A;  5D1U A;  1UTT A;  4HX3 A;  3AYU A;  1CK7 A;  4H82 A;  1CIZ A;  4GF1 A;  1BKC E;  1SAT A;  1QJI A;  3EWJ A;  2OY4 A;  1B8Y A;  2WOA A;  4J4M A;  2V4B A;  2WO8 A;  4HMA A;  1JIZ A;  2XS3 A;  1Y93 A;  3N2V A;  3HY9 A;  2JIH A;  1BQQ M;  1GO8 P;  2O3E A;  2AYK A;  3EHY A;  1PWQ A;  1L6J A;  2ERO A;  3TS4 A;  1KUI A;  2XS4 A;  4EFS A;  4GR3 A;  3GBO A;  1FM1 A;  3LKA A;  1Z3J A;  1MMQ A;  3I7I A;  1Y8J A;  1PWV A;  5I2Z A;  1MNC A;  3DSL A;  4PKW A;  4L19 A;  4GR0 A;  1QJJ A;  2OXZ A;  2N8R A;  4JQG A;  1BSW A;  1ZTQ A;  1OS9 A;  2W14 A;  3TSK A;  1QIB A;  1Q3A A;  1R54 A;  2X3C A;  1SMP A;  2J0T A;  3NX7 A;  3RTS A;  3G42 A;  4AXQ A;  4JPA A;  1OM7 A;  2OI0 A;  4I35 A;  3WV2 A;  1AF0 A;  1GXD A;  1IAA A;  5BOY A;  3F19 A;  1CXV A;  1MMB A;  3LMC A;  3F17 A;  4G9L A;  3K7L A;  3LIK A;  4H1Q A;  1DTH A;  3HYG A;  1A85 A;  3UVC A;  1DMT A;  4H49 A;  1OM6 A;  3G5C A;  4XCT A;  1I73 A;  1BUD A;  3EDI A;  1ZS0 A;  830C A;  1GE7 A;  1XFV A;  1ND1 A;  5I43 A;  4FXQ A;  2RJP A;  3P24 A;  3KHI A;  3KEC A;  3ZVS A;  1BM6 A;  1CQR A;  2SRT A;  4IUW A;  3AIG A;  3P1V A;  1SLN A;  1G12 A;  2KRJ A;  1CAQ A;  1AST A;  1JIW P;  1K7G A;  3O2X A;  1I76 A;  3EDH A;  3I7G A;  3KRY A;  4ON1 A;  1GE6 A;  3DL1 A;  2OVZ A;  2AIG P;  1YP1 A;  3EDG A;  3HB2 P;  456C A;  1HY7 A;  2OXU A;  2JT6 A; 
#chains in the Genus database with same CATH topology
 1KUH A;  4WKE A;  3EDZ A;  1RMZ A;  1EAK A;  4WF6 A;  1QIA A;  1EB6 A;  4H76 A;  3LEA A;  1I1I P;  1OM8 A;  4GR8 A;  1CGE A;  4I03 A;  1UMS A;  1J7N A;  4WK7 A;  1JH1 A;  1XFW A;  1GE5 A;  2D1O A;  1C8T A;  1BKC A;  2W0D A;  5B5P A;  3WV3 A;  1Y0V A;  4DPE A;  4WKI A;  1SRP A;  1FLS A;  4AIG A;  3F18 A;  1IAE A;  3LUM A;  3TVC A;  4JP4 A;  1BZS A;  1UEA A;  1MMP A;  1ZXV A;  2Z2D A;  2FV9 A;  1CGL A;  1JJ9 A;  4AYK A;  3DPE A;  1QIC A;  1XUC A;  1H71 P;  2W15 A;  5I4O A;  3DPF A;  1A86 A;  3OHO A;  1R1J A;  1G4K A;  3OHL A;  3MA2 A;  3VI1 A;  5I0L A;  1PWW A;  4A3W A;  1HV5 A;  2DDY A;  4ILW D;  2Y6C A;  1KUK A;  3LE9 A;  3DNG A;  1O0Q A;  1USN A;  3F16 A;  1BIW A;  2J83 A;  3O64 A;  1IAC A;  3F1A A;  4DV8 A;  2JT5 A;  5BPA A;  4JIJ A;  1BQO A;  2MLS A;  4H30 A;  4QKZ A;  2USN A;  2JSD A;  4DD8 A;  1JKY A;  3N2U A;  4AUO A;  2MLR A;  4Q1L A;  2OY2 A;  1IAB A;  1PWU A;  1C7K A;  3HBV P;  4XM8 A;  4CTH A;  1R1I A;  1HFC A;  2DDF A;  5L7F A;  2OVX A;  2W13 A;  1ZP5 A;  4XM7 A;  3USN A;  3ZXH A;  3CKI A;  1R1H A;  2O36 A;  1IAG A;  2W12 A;  1ZXC A;  3LUN A;  4ZR5 A;  4GWN A;  4PKV A;  5D7W A;  1KUG A;  4GQL A;  4A7B A;  1FBL A;  2QPJ A;  2X3A A;  1JK3 A;  1BKC I;  1GO7 P;  4JA1 A;  2DW1 A;  1D8F A;  1B3D A;  5I3M A;  3VTG A;  1BUV M;  3LJT A;  2CLT A;  1HTD A;  3K7N A;  3V96 B;  4PKU A;  1WNI A;  2D1N A;  1KAP P;  3LGP A;  1PWP A;  4IN9 A;  1YOU A;  1R55 A;  4H84 A;  3BA0 A;  5L79 A;  1D5J A;  1G05 A;  1EUB A;  2L0R A;  2WO9 A;  4XBH A;  5D1S A;  5CUH A;  1JAO A;  4L63 A;  3HDB A;  5H8X A;  1MMR A;  4PKR A;  2OW0 A;  2MZI A;  1YCM A;  5I12 A;  3F15 A;  1JAQ A;  1OO9 A;  4DF9 A;  4FU4 A;  1HOV A;  4FXY P;  1XFZ A;  2CKI A;  5JMY A;  3LJZ A;  1XFY A;  1D7X A;  3AYK A;  1XUD A;  1KUF A;  3ZUK A;  4G0D A;  2JNP A;  3HY7 A;  1K7Q A;  4PKQ A;  5CZM A;  1UTZ A;  2OZR A;  1AKL A;  3KEK A;  2DW2 A;  1GKC A;  2Y6D A;  3TT4 A;  3LIL A;  3B2Z A;  4H3X A;  2ERP A;  3KEJ A;  3DWB A;  2PJT A;  2K2G A;  1QUA A;  2OW9 A;  3Q2G A;  1K7I A;  3KWV C;  1SLM A;  3LQB A;  2E3X A;  3U1R A;  3SHI A;  1CGF A;  1XM5 A;  2X7M A;  1KBC A;  4L6T A;  3LQ0 A;  1SU3 A;  1IAD A;  3HDA P;  1G9K A;  5B5O A;  1JAP A;  1XAX A;  5LAB A;  4L7A A;  2OW2 A;  3E8R A;  2POJ A;  2X3B A;  3KMC A;  1G49 A;  3EHX A;  2DW0 A;  3ELM A;  2I47 A;  1JAN A;  3RTT A;  2OW1 A;  5D2B A;  3HBU P;  1XFX A;  1XUR A;  3L0V A;  1ATL A;  3LK8 A;  4WZV A;  1AYK A;  3KME A;  1XFU A;  2RJQ A;  4H2E A;  3LIR A;  1GKD A;  4R3V A;  3WV1 A;  1S4B P;  2FV5 A;  3B8Z A;  2E2D A;  2ERQ A;  4PKS A;  1OMJ A;  1C3I A;  1HFS A;  2K9C A;  4IJO A;  2HU6 A;  4FVL A;  5D1T A;  2YB9 A;  2OXW A;  4XM6 A;  3Q2H A;  1UMT A;  1ZVX A;  2MZE A;  5CXA A;  4GWM A;  4PKT A;  5D3C A;  2A8H A;  3L0T A;  1O0T A;  5BOT A;  966C A;  3LJG A;  1RM8 A;  2MZH A;  1YQY A;  3B92 A;  1OS2 A;  2TCL A;  1D8M A;  4GUY A;  2YIG A;  1ROS A;  5D1U A;  1UTT A;  4HX3 A;  3AYU A;  1CK7 A;  4H82 A;  1CIZ A;  4GF1 A;  1BKC E;  1SAT A;  1QJI A;  3EWJ A;  2OY4 A;  1B8Y A;  2WOA A;  4J4M A;  2V4B A;  2WO8 A;  4HMA A;  1JIZ A;  2XS3 A;  1Y93 A;  3N2V A;  3HY9 A;  2JIH A;  1BQQ M;  1GO8 P;  2O3E A;  2AYK A;  3EHY A;  1PWQ A;  1L6J A;  2ERO A;  3TS4 A;  1KUI A;  2XS4 A;  4EFS A;  4GR3 A;  3GBO A;  1FM1 A;  3LKA A;  1Z3J A;  2YUF A;  1MMQ A;  3I7I A;  1Y8J A;  1PWV A;  5I2Z A;  1MNC A;  3DSL A;  4PKW A;  4L19 A;  4GR0 A;  1QJJ A;  2OXZ A;  2N8R A;  4JQG A;  1BSW A;  3DTK A;  1TVI A;  1ZTQ A;  3DTE A;  1OS9 A;  2W14 A;  3TSK A;  1QIB A;  1Q3A A;  1R54 A;  2X3C A;  1SMP A;  2J0T A;  3NX7 A;  3RTS A;  3G42 A;  4AXQ A;  4JPA A;  1OM7 A;  2OI0 A;  4I35 A;  3WV2 A;  1AF0 A;  1GXD A;  1IAA A;  5BOY A;  3F19 A;  1CXV A;  1MMB A;  3LMC A;  3F17 A;  4G9L A;  3K7L A;  3LIK A;  4H1Q A;  1DTH A;  3HYG A;  1A85 A;  3UVC A;  1OZ9 A;  1DMT A;  4H49 A;  1OM6 A;  3G5C A;  4XCT A;  1I73 A;  1BUD A;  3EDI A;  1ZS0 A;  830C A;  1GE7 A;  1XFV A;  1ND1 A;  5I43 A;  4FXQ A;  2RJP A;  3P24 A;  3KHI A;  3KEC A;  3ZVS A;  1BM6 A;  1CQR A;  2SRT A;  4IUW A;  3AIG A;  3P1V A;  1SLN A;  1G12 A;  2KRJ A;  1CAQ A;  1AST A;  1JIW P;  1K7G A;  3O2X A;  1I76 A;  3EDH A;  3I7G A;  3KRY A;  4ON1 A;  1GE6 A;  3DL1 A;  3DTI A;  2OVZ A;  2AIG P;  1YP1 A;  3EDG A;  3HB2 P;  456C A;  1HY7 A;  2OXU A;  2JT6 A; 
#chains in the Genus database with same CATH homology
 1KUH A;  4WKE A;  3EDZ A;  1RMZ A;  1EAK A;  4WF6 A;  1QIA A;  1EB6 A;  4H76 A;  3LEA A;  1I1I P;  1OM8 A;  4GR8 A;  1CGE A;  4I03 A;  1UMS A;  1J7N A;  4WK7 A;  1JH1 A;  1XFW A;  1GE5 A;  2D1O A;  1C8T A;  1BKC A;  2W0D A;  5B5P A;  3WV3 A;  1Y0V A;  4DPE A;  4WKI A;  1SRP A;  1FLS A;  4AIG A;  3F18 A;  1IAE A;  3LUM A;  3TVC A;  4JP4 A;  1BZS A;  1UEA A;  1MMP A;  1ZXV A;  2Z2D A;  2FV9 A;  1CGL A;  1JJ9 A;  4AYK A;  3DPE A;  1QIC A;  1XUC A;  1H71 P;  2W15 A;  5I4O A;  3DPF A;  1A86 A;  3OHO A;  1R1J A;  1G4K A;  3OHL A;  3MA2 A;  3VI1 A;  5I0L A;  1PWW A;  4A3W A;  1HV5 A;  2DDY A;  4ILW D;  2Y6C A;  1KUK A;  3LE9 A;  3DNG A;  1O0Q A;  1USN A;  3F16 A;  1BIW A;  2J83 A;  3O64 A;  1IAC A;  3F1A A;  4DV8 A;  2JT5 A;  5BPA A;  4JIJ A;  1BQO A;  2MLS A;  4H30 A;  4QKZ A;  2USN A;  2JSD A;  4DD8 A;  1JKY A;  3N2U A;  4AUO A;  2MLR A;  4Q1L A;  2OY2 A;  1IAB A;  1PWU A;  1C7K A;  3HBV P;  4XM8 A;  4CTH A;  1R1I A;  1HFC A;  2DDF A;  5L7F A;  2OVX A;  2W13 A;  1ZP5 A;  4XM7 A;  3USN A;  3ZXH A;  3CKI A;  1R1H A;  2O36 A;  1IAG A;  2W12 A;  1ZXC A;  3LUN A;  4ZR5 A;  4GWN A;  4PKV A;  5D7W A;  1KUG A;  4GQL A;  4A7B A;  1FBL A;  2QPJ A;  2X3A A;  1JK3 A;  1BKC I;  1GO7 P;  4JA1 A;  2DW1 A;  1D8F A;  1B3D A;  5I3M A;  3VTG A;  1BUV M;  3LJT A;  2CLT A;  1HTD A;  3K7N A;  3V96 B;  4PKU A;  1WNI A;  2D1N A;  1KAP P;  3LGP A;  1PWP A;  4IN9 A;  1YOU A;  1R55 A;  4H84 A;  3BA0 A;  5L79 A;  1D5J A;  1G05 A;  1EUB A;  2L0R A;  2WO9 A;  4XBH A;  5D1S A;  5CUH A;  1JAO A;  4L63 A;  3HDB A;  5H8X A;  1MMR A;  4PKR A;  2OW0 A;  2MZI A;  1YCM A;  5I12 A;  3F15 A;  1JAQ A;  1OO9 A;  4DF9 A;  4FU4 A;  1HOV A;  4FXY P;  1XFZ A;  2CKI A;  5JMY A;  3LJZ A;  1XFY A;  1D7X A;  3AYK A;  1XUD A;  1KUF A;  3ZUK A;  4G0D A;  2JNP A;  3HY7 A;  1K7Q A;  4PKQ A;  5CZM A;  1UTZ A;  2OZR A;  1AKL A;  3KEK A;  2DW2 A;  1GKC A;  2Y6D A;  3TT4 A;  3LIL A;  3B2Z A;  4H3X A;  2ERP A;  3KEJ A;  3DWB A;  2PJT A;  2K2G A;  1QUA A;  2OW9 A;  3Q2G A;  1K7I A;  3KWV C;  1SLM A;  3LQB A;  2E3X A;  3U1R A;  3SHI A;  1CGF A;  2X7M A;  1KBC A;  4L6T A;  3LQ0 A;  1SU3 A;  1IAD A;  3HDA P;  1G9K A;  5B5O A;  1JAP A;  5LAB A;  4L7A A;  2OW2 A;  3E8R A;  2POJ A;  2X3B A;  3KMC A;  1G49 A;  3EHX A;  2DW0 A;  3ELM A;  2I47 A;  1JAN A;  3RTT A;  2OW1 A;  5D2B A;  3HBU P;  1XFX A;  1XUR A;  3L0V A;  1ATL A;  3LK8 A;  4WZV A;  1AYK A;  3KME A;  1XFU A;  2RJQ A;  4H2E A;  3LIR A;  1GKD A;  4R3V A;  3WV1 A;  1S4B P;  2FV5 A;  3B8Z A;  2E2D A;  2ERQ A;  4PKS A;  1OMJ A;  1C3I A;  1HFS A;  2K9C A;  4IJO A;  2HU6 A;  4FVL A;  5D1T A;  2YB9 A;  2OXW A;  4XM6 A;  3Q2H A;  1UMT A;  1ZVX A;  2MZE A;  5CXA A;  4GWM A;  4PKT A;  5D3C A;  2A8H A;  3L0T A;  1O0T A;  5BOT A;  966C A;  3LJG A;  1RM8 A;  2MZH A;  1YQY A;  3B92 A;  1OS2 A;  2TCL A;  1D8M A;  4GUY A;  2YIG A;  1ROS A;  5D1U A;  1UTT A;  4HX3 A;  3AYU A;  1CK7 A;  4H82 A;  1CIZ A;  4GF1 A;  1BKC E;  1SAT A;  1QJI A;  3EWJ A;  2OY4 A;  1B8Y A;  2WOA A;  4J4M A;  2V4B A;  2WO8 A;  4HMA A;  1JIZ A;  2XS3 A;  1Y93 A;  3N2V A;  3HY9 A;  2JIH A;  1BQQ M;  1GO8 P;  2O3E A;  2AYK A;  3EHY A;  1PWQ A;  1L6J A;  2ERO A;  3TS4 A;  1KUI A;  2XS4 A;  4EFS A;  4GR3 A;  3GBO A;  1FM1 A;  3LKA A;  1Z3J A;  2YUF A;  1MMQ A;  3I7I A;  1Y8J A;  1PWV A;  5I2Z A;  1MNC A;  3DSL A;  4PKW A;  4L19 A;  4GR0 A;  1QJJ A;  2OXZ A;  2N8R A;  4JQG A;  1BSW A;  3DTK A;  1ZTQ A;  3DTE A;  1OS9 A;  2W14 A;  3TSK A;  1QIB A;  1Q3A A;  1R54 A;  2X3C A;  1SMP A;  2J0T A;  3NX7 A;  3RTS A;  3G42 A;  4AXQ A;  4JPA A;  1OM7 A;  2OI0 A;  4I35 A;  3WV2 A;  1AF0 A;  1GXD A;  1IAA A;  5BOY A;  3F19 A;  1CXV A;  1MMB A;  3LMC A;  3F17 A;  4G9L A;  3K7L A;  3LIK A;  4H1Q A;  1DTH A;  3HYG A;  1A85 A;  3UVC A;  1DMT A;  4H49 A;  1OM6 A;  3G5C A;  4XCT A;  1I73 A;  1BUD A;  3EDI A;  1ZS0 A;  830C A;  1GE7 A;  1XFV A;  1ND1 A;  5I43 A;  4FXQ A;  2RJP A;  3P24 A;  3KHI A;  3KEC A;  3ZVS A;  1BM6 A;  1CQR A;  2SRT A;  4IUW A;  3AIG A;  3P1V A;  1SLN A;  1G12 A;  2KRJ A;  1CAQ A;  1AST A;  1JIW P;  1K7G A;  3O2X A;  1I76 A;  3EDH A;  3I7G A;  3KRY A;  4ON1 A;  1GE6 A;  3DL1 A;  3DTI A;  2OVZ A;  2AIG P;  1YP1 A;  3EDG A;  3HB2 P;  456C A;  1HY7 A;  2OXU A;  2JT6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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