3KMEA

Crystal structure of catalytic domain of tace with phenyl-pyrrolidinyl-tartrate inhibitor
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
257
structure length
253
Chain Sequence
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TNF-alpha-converting enzyme
total genus 80
structure length 253
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2009-11-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3kmeA00
1XFWA 2X3AA 1Y0VA 1D7XA 3HY9A 1I73A 1JAOA 4GF1A 3SHIA 1ZTQA 1ZP5A 2ERPA 3P24A 1C7KA 1UTTA 2CLTA 1GO7P 5CUHA 3KEKA 4H49A 3HYGA 3EDIA 4AXQA 2Z2DA 2W13A 5I4OA 1BZSA 4H76A 1GE5A 4H84A 4WZVA 2OY4A 3AIGA 2YIGA 4QKZA 2JT5A 2K9CA 5D3CA 5L7FA 2I47A 3VI1A 1XFXA 2MZIA 1Y93A 3O2XA 3EDZA 1FBLA 5D7WA 3V96B 830CA 1A85A 4XM6A 1D8MA 3EHYA 1SMPA 5LABA 1FM1A 4JIJA 4PKWA 2HU6A 3DNGA 1H71P 3HDBA 1PWUA 1BSWA 3RTTA 2WOAA 4WF6A 2N8RA 1UMSA 3U1RA 3LIRA 1PWQA 2V4BA 1BIWA 3EWJA 1GKDA 3G5CA 4ON1A 1QIBA 3F16A 3L0TA 1KUKA 1K7IA 3KMEA 2FV5A 1R55A 2J83A 3LE9A 2X7MA 3UVCA 2J0TA 2L0RA 4WKEA 3P1VA 2Y6DA 2EROA 1KUFA 1L6JA 1MMQA 2E3XA 1CGEA 3HDAP 3KHIA 2TCLA 1XURA 3F17A 1XUDA 1CQRA 4FVLA 3TVCA 3NX7A 1Z3JA 3LGPA 1BQOA 1UEAA 3LEAA 3EDHA 2E2DA 4XM8A 1CK7A 2WO9A 1OMJA 1G49A 3O64A 3I7GA 4ZR5A 4JP4A 1EAKA 2RJPA 3B8ZA 4GUYA 1MMPA 3B92A 1FLSA 1JAQA 3WV1A 2XS4A 2MZHA 1XFZA 4PKQA 1CGFA 1I76A 4H30A 4IUWA 3TT4A 1IACA 2ERQA 1YQYA 2CKIA 3HBUP 1K7GA 3KRYA 1ZXVA 1CXVA 4AIGA 1PWWA 4FU4A 2DW1A 3LMCA 3LJGA 1QUAA 4J4MA 5I43A 4FXQA 3KEJA 1I1IP 1IADA 2USNA 2DW0A 3F15A 3DWBA 4I03A 1RMZA 3WV3A 5D1TA 1HTDA 2W15A 3HY7A 4PKVA 4R3VA 2X3BA 1QJJA 1HV5A 4JA1A 1GE6A 3LUNA 3E8RA 1BKCE 3OHOA 1S4BP 2W0DA 1JANA 3USNA 3LIKA 1R1HA 1SATA 4JPAA 1G05A 1G9KA 1OM6A 2W12A 1BM6A 2JT6A 3DSLA 1ZVXA 1USNA 3ELMA 1IAAA 1B8YA 1JIZA 1KUIA 1QICA 1SU3A 1ZXCA 1EUBA 1R1IA 2A8HA 1SLNA 2Y6CA 3LJTA 5BOTA 1A86A 2OXWA 4H2EA 1HOVA 1BKCI 5D1SA 1GO8P 4PKUA 3N2VA 4GWNA 1BUDA 3ZUKA 1B3DA 5BOYA 5L79A 4PKTA 1OO9A 3K7NA 1IAGA 1AKLA 5I2ZA 1AYKA 2OW0A 2OW9A 2POJA 1RM8A 1G4KA 4ILWD 5JMYA 4IJOA 1SLMA 4XBHA 3Q2HA 3DPFA 1J7NA 1G12A 1QJIA 4EFSA 4G0DA 966CA 1QIAA 5H8XA 2MZEA 2OVXA 3EDGA 1XFYA 1PWVA 1XFUA 3F1AA 1K7QA 1JAPA 1R54A 5BPAA 4DV8A 1BKCA 1R1JA 1BUVM 1C8TA 4L19A 3GBOA 5I0LA 1MMBA 4G9LA 3I7IA 1UMTA 4PKRA 1KBCA 2SRTA 3VTGA 4WK7A 2OW1A 4H3XA 2MLRA 3BA0A 2MLSA 4PKSA 5CXAA 3LQBA 4Q1LA 3CKIA 2XS3A 1PWPA 2K2GA 1GXDA 1XFVA 1KAPP 3LK8A 4CTHA 4HMAA 3F18A 1Q3AA 1YCMA 2X3CA 2AYKA 1HFSA 1CAQA 2FV9A 4L63A 1ASTA 1AF0A 1MNCA 3LUMA 3TSKA 1CGLA 3Q2GA 3K7LA 4GR3A 1ATLA 1MMRA 3LILA 4DD8A 3MA2A 4A3WA 4FXYP 3KMCA 1GE7A 4DPEA 2D1OA 3EHXA 3KECA 1GKCA 1ZS0A 2JIHA 3ZXHA 2O3EA 2OXUA 1D5JA 2D1NA 3KWVC 4HX3A 5I3MA 4JQGA 3DL1A 4XM7A 5D2BA 2AIGP 1OS9A 3L0VA 1HY7A 1OM7A 3OHLA 2JNPA 2DW2A 2OVZA 3ZVSA 1SRPA 4IN9A 2OI0A 1JK3A 1OS2A 3N2UA 4AYKA 3DPEA 3TS4A 2OW2A 2DDFA 2OXZA 5CZMA 2RJQA 1KUHA 4GR8A 4A7BA 1OM8A 1JKYA 2DDYA 4WKIA 4GWMA 1C3IA 3F19A 4H1QA 2OZRA 5I12A 1EB6A 1WNIA 1CIZA 1XUCA 4I35A 3WV2A 1HFCA 1UTZA 4GR0A 1IABA 1ND1A 1O0QA 1JH1A 2QPJA 1JIWP 3AYUA 2JSDA 5B5OA 4L6TA 1KUGA 4DF9A 1DMTA 1IAEA 3AYKA 3HB2P 3LKAA 2W14A 2WO8A 1YOUA 2YB9A 3G42A 1YP1A 5B5PA 1D8FA 4AUOA 1Y8JA 4H82A 2O36A 1BQQM 1DTHA 5D1UA 4GQLA 3LQ0A 3HBVP 3LJZA 1ROSA 2KRJA 3B2ZA 3RTSA 2PJTA 1JJ9A 456CA 2OY2A 4XCTA 1O0TA
chains in the Genus database with same CATH superfamily
1XFWA 2X3AA 1Y0VA 1D7XA 3HY9A 1I73A 1JAOA 4GF1A 3SHIA 1ZTQA 1ZP5A 2ERPA 3P24A 1C7KA 1UTTA 2CLTA 1GO7P 5CUHA 3KEKA 4H49A 3HYGA 3EDIA 4AXQA 2Z2DA 2W13A 5I4OA 1BZSA 4H76A 1GE5A 4H84A 4WZVA 2OY4A 3AIGA 2YIGA 4QKZA 2JT5A 2K9CA 5D3CA 5L7FA 2I47A 3VI1A 1XFXA 2MZIA 1Y93A 3O2XA 3EDZA 1FBLA 5D7WA 3V96B 830CA 1A85A 4XM6A 1D8MA 3EHYA 1SMPA 5LABA 1FM1A 4JIJA 4PKWA 2HU6A 3DNGA 1H71P 3HDBA 1PWUA 1BSWA 3RTTA 2WOAA 3DTIA 4WF6A 2N8RA 1UMSA 3U1RA 3LIRA 1PWQA 2V4BA 1BIWA 3EWJA 1GKDA 3G5CA 4ON1A 1QIBA 3F16A 3L0TA 1KUKA 1K7IA 3KMEA 2FV5A 1R55A 2J83A 3LE9A 2X7MA 3UVCA 4L7AA 2J0TA 2L0RA 4WKEA 3P1VA 2Y6DA 2EROA 1KUFA 1L6JA 1MMQA 2E3XA 1CGEA 3HDAP 3KHIA 2TCLA 1XURA 3F17A 1XUDA 1CQRA 4FVLA 3TVCA 3NX7A 1Z3JA 3LGPA 1BQOA 1UEAA 3LEAA 3EDHA 2E2DA 4XM8A 1CK7A 2WO9A 1OMJA 1G49A 3O64A 3I7GA 4ZR5A 4JP4A 1EAKA 2RJPA 3B8ZA 4GUYA 1MMPA 3B92A 1FLSA 1JAQA 3WV1A 2XS4A 2MZHA 1XFZA 4PKQA 1CGFA 1I76A 4H30A 4IUWA 3TT4A 1IACA 2ERQA 1YQYA 2CKIA 3HBUP 1K7GA 3KRYA 1XAXA 1ZXVA 1CXVA 4AIGA 1PWWA 4FU4A 2DW1A 3LMCA 3LJGA 1QUAA 4J4MA 5I43A 4FXQA 3KEJA 1I1IP 1IADA 2USNA 2DW0A 3F15A 3DWBA 4I03A 1RMZA 3WV3A 5D1TA 1HTDA 2W15A 3HY7A 4PKVA 4R3VA 2X3BA 1QJJA 1HV5A 4JA1A 1GE6A 3LUNA 3E8RA 1BKCE 3OHOA 1S4BP 2W0DA 1JANA 3USNA 3LIKA 1R1HA 1SATA 4JPAA 1G05A 1XM5A 1G9KA 1OM6A 2W12A 1BM6A 2JT6A 3DSLA 1ZVXA 1USNA 3ELMA 1IAAA 1B8YA 1JIZA 1KUIA 1QICA 1SU3A 1ZXCA 1EUBA 1R1IA 2A8HA 1SLNA 2Y6CA 3LJTA 5BOTA 1A86A 2OXWA 4H2EA 1HOVA 1BKCI 5D1SA 1GO8P 4PKUA 3N2VA 4GWNA 1BUDA 3ZUKA 1B3DA 5BOYA 5L79A 4PKTA 1OO9A 3K7NA 1IAGA 1AKLA 5I2ZA 1AYKA 2OW0A 2OW9A 2POJA 1RM8A 1G4KA 4ILWD 5JMYA 4IJOA 1SLMA 4XBHA 3Q2HA 3DPFA 1J7NA 1G12A 1QJIA 4EFSA 4G0DA 966CA 1QIAA 5H8XA 2MZEA 2OVXA 3EDGA 1XFYA 1PWVA 1XFUA 3F1AA 1K7QA 1JAPA 1R54A 5BPAA 4DV8A 1BKCA 1R1JA 1BUVM 1C8TA 4L19A 3GBOA 5I0LA 1OZ9A 1MMBA 4G9LA 3I7IA 1UMTA 4PKRA 1KBCA 2SRTA 3VTGA 4WK7A 2OW1A 4H3XA 2MLRA 3BA0A 2MLSA 4PKSA 5CXAA 3LQBA 4Q1LA 3CKIA 2XS3A 1PWPA 2K2GA 1GXDA 1XFVA 1KAPP 3LK8A 4CTHA 4HMAA 3F18A 1Q3AA 1YCMA 2X3CA 2AYKA 1HFSA 1CAQA 2FV9A 4L63A 1ASTA 1AF0A 1MNCA 3LUMA 3TSKA 1CGLA 3Q2GA 3K7LA 4GR3A 1ATLA 1MMRA 3LILA 4DD8A 3MA2A 4A3WA 4FXYP 3KMCA 1GE7A 4DPEA 2D1OA 3EHXA 3DTEA 3KECA 1GKCA 1ZS0A 2JIHA 3ZXHA 2O3EA 3DTKA 2OXUA 1D5JA 2D1NA 3KWVC 4HX3A 5I3MA 4JQGA 3DL1A 4XM7A 5D2BA 2YUFA 2AIGP 1OS9A 3L0VA 1HY7A 1OM7A 3OHLA 2JNPA 2DW2A 2OVZA 3ZVSA 1SRPA 4IN9A 2OI0A 1JK3A 1OS2A 3N2UA 4AYKA 3DPEA 3TS4A 2OW2A 2DDFA 2OXZA 5CZMA 2RJQA 1KUHA 4GR8A 4A7BA 1OM8A 1JKYA 2DDYA 4WKIA 4GWMA 1C3IA 3F19A 4H1QA 2OZRA 5I12A 1EB6A 1WNIA 1CIZA 1XUCA 4I35A 3WV2A 1HFCA 1UTZA 4GR0A 1IABA 1ND1A 1O0QA 1TVIA 1JH1A 2QPJA 1JIWP 3AYUA 2JSDA 5B5OA 4L6TA 1KUGA 4DF9A 1DMTA 1IAEA 3AYKA 3HB2P 3LKAA 2W14A 2WO8A 1YOUA 2YB9A 3G42A 1YP1A 5B5PA 1D8FA 4AUOA 1Y8JA 4H82A 2O36A 1BQQM 1DTHA 5D1UA 4GQLA 3LQ0A 3HBVP 1ROSA 2KRJA 3LJZA 3B2ZA 3RTSA 2PJTA 1JJ9A 456CA 2OY2A 4XCTA 1O0TA
chains in the Genus database with same CATH topology
1XFWA 2X3AA 1Y0VA 1D7XA 3HY9A 1I73A 1JAOA 4GF1A 3SHIA 1ZTQA 1ZP5A 2ERPA 3P24A 1C7KA 1UTTA 2CLTA 1GO7P 5CUHA 3KEKA 4H49A 3HYGA 3EDIA 4AXQA 2Z2DA 2W13A 5I4OA 1BZSA 4H76A 1GE5A 4H84A 4WZVA 2OY4A 3AIGA 2YIGA 4QKZA 2JT5A 2K9CA 5D3CA 5L7FA 2I47A 3VI1A 1XFXA 2MZIA 1Y93A 3O2XA 3EDZA 1FBLA 5D7WA 3V96B 830CA 1A85A 4XM6A 1D8MA 3EHYA 1SMPA 5LABA 1FM1A 4JIJA 4PKWA 2HU6A 3DNGA 1H71P 3HDBA 1PWUA 1BSWA 3RTTA 2WOAA 3DTIA 4WF6A 2N8RA 1UMSA 3U1RA 3LIRA 1PWQA 2V4BA 1BIWA 3EWJA 1GKDA 3G5CA 4ON1A 1QIBA 3F16A 3L0TA 1KUKA 1K7IA 3KMEA 2FV5A 1R55A 2J83A 3LE9A 2X7MA 3UVCA 4L7AA 2J0TA 2L0RA 4WKEA 3P1VA 2Y6DA 2EROA 1KUFA 1L6JA 1MMQA 2E3XA 1CGEA 3HDAP 3KHIA 2TCLA 1XURA 3F17A 1XUDA 1CQRA 4FVLA 3TVCA 3NX7A 1Z3JA 3LGPA 1BQOA 1UEAA 3LEAA 3EDHA 2E2DA 4XM8A 1CK7A 2WO9A 1OMJA 1G49A 3O64A 3I7GA 4ZR5A 4JP4A 1EAKA 2RJPA 3B8ZA 4GUYA 1MMPA 3B92A 1FLSA 1JAQA 3WV1A 2XS4A 2MZHA 1XFZA 4PKQA 1CGFA 1I76A 4H30A 4IUWA 3TT4A 1IACA 2ERQA 1YQYA 2CKIA 3HBUP 1K7GA 3KRYA 1ZXVA 1CXVA 4AIGA 1PWWA 4FU4A 2DW1A 3LMCA 3LJGA 1QUAA 4J4MA 5I43A 4FXQA 3KEJA 1I1IP 1IADA 2USNA 2DW0A 3F15A 3DWBA 4I03A 1RMZA 3WV3A 5D1TA 1HTDA 2W15A 3HY7A 4PKVA 4R3VA 2X3BA 1QJJA 1HV5A 4JA1A 1GE6A 3LUNA 3E8RA 1BKCE 3OHOA 1S4BP 2W0DA 1JANA 3USNA 3LIKA 1R1HA 1SATA 4JPAA 1G05A 1G9KA 1OM6A 2W12A 1BM6A 2JT6A 3DSLA 1ZVXA 1USNA 3ELMA 1IAAA 1B8YA 1JIZA 1KUIA 1QICA 1SU3A 1ZXCA 1EUBA 1R1IA 2A8HA 1SLNA 2Y6CA 3LJTA 5BOTA 1A86A 2OXWA 4H2EA 1HOVA 1BKCI 5D1SA 1GO8P 4PKUA 3N2VA 4GWNA 1BUDA 3ZUKA 1B3DA 5BOYA 5L79A 4PKTA 1OO9A 3K7NA 1IAGA 1AKLA 5I2ZA 1AYKA 2OW0A 2OW9A 2POJA 1RM8A 1G4KA 4ILWD 5JMYA 4IJOA 1SLMA 4XBHA 3Q2HA 3DPFA 1J7NA 1G12A 1QJIA 4EFSA 4G0DA 966CA 1QIAA 5H8XA 2MZEA 2OVXA 3EDGA 1XFYA 1PWVA 1XFUA 3F1AA 1K7QA 1JAPA 1R54A 5BPAA 4DV8A 1BKCA 1R1JA 1BUVM 1C8TA 4L19A 3GBOA 5I0LA 1MMBA 4G9LA 3I7IA 1UMTA 4PKRA 1KBCA 2SRTA 3VTGA 4WK7A 2OW1A 4H3XA 2MLRA 3BA0A 2MLSA 4PKSA 5CXAA 3LQBA 4Q1LA 3CKIA 2XS3A 1PWPA 2K2GA 1GXDA 1XFVA 1KAPP 3LK8A 4CTHA 4HMAA 3F18A 1Q3AA 1YCMA 2X3CA 2AYKA 1HFSA 1CAQA 2FV9A 4L63A 1ASTA 1AF0A 1MNCA 3LUMA 3TSKA 1CGLA 3Q2GA 3K7LA 4GR3A 1ATLA 1MMRA 3LILA 4DD8A 3MA2A 4A3WA 4FXYP 3KMCA 1GE7A 4DPEA 2D1OA 3EHXA 3DTEA 3KECA 1GKCA 1ZS0A 2JIHA 3ZXHA 2O3EA 3DTKA 2OXUA 1D5JA 2D1NA 3KWVC 4HX3A 5I3MA 4JQGA 3DL1A 4XM7A 5D2BA 2YUFA 2AIGP 1OS9A 3L0VA 1HY7A 1OM7A 3OHLA 2JNPA 2DW2A 2OVZA 3ZVSA 1SRPA 4IN9A 2OI0A 1JK3A 1OS2A 3N2UA 4AYKA 3DPEA 3TS4A 2OW2A 2DDFA 2OXZA 5CZMA 2RJQA 1KUHA 4GR8A 4A7BA 1OM8A 1JKYA 2DDYA 4WKIA 4GWMA 1C3IA 3F19A 4H1QA 2OZRA 5I12A 1EB6A 1WNIA 1CIZA 1XUCA 4I35A 3WV2A 1HFCA 1UTZA 4GR0A 1IABA 1ND1A 1O0QA 1JH1A 2QPJA 1JIWP 3AYUA 2JSDA 5B5OA 4L6TA 1KUGA 4DF9A 1DMTA 1IAEA 3AYKA 3HB2P 3LKAA 2W14A 2WO8A 1YOUA 2YB9A 3G42A 1YP1A 5B5PA 1D8FA 4AUOA 1Y8JA 4H82A 2O36A 1BQQM 1DTHA 5D1UA 4GQLA 3LQ0A 3HBVP 3LJZA 1ROSA 2KRJA 3B2ZA 3RTSA 2PJTA 1JJ9A 456CA 2OY2A 4XCTA 1O0TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XFW A;  2X3A A;  1Y0V A;  1D7X A;  3HY9 A;  1I73 A;  1JAO A;  4GF1 A;  3SHI A;  1ZTQ A;  1ZP5 A;  2ERP A;  3P24 A;  1C7K A;  1UTT A;  2CLT A;  1GO7 P;  5CUH A;  3KEK A;  4H49 A;  3HYG A;  3EDI A;  4AXQ A;  2Z2D A;  2W13 A;  5I4O A;  1BZS A;  4H76 A;  1GE5 A;  4H84 A;  4WZV A;  2OY4 A;  3AIG A;  2YIG A;  4QKZ A;  2JT5 A;  2K9C A;  5D3C A;  5L7F A;  2I47 A;  3VI1 A;  1XFX A;  2MZI A;  1Y93 A;  3O2X A;  3EDZ A;  1FBL A;  5D7W A;  3V96 B;  830C A;  1A85 A;  4XM6 A;  1D8M A;  3EHY A;  1SMP A;  5LAB A;  1FM1 A;  4JIJ A;  4PKW A;  2HU6 A;  3DNG A;  1H71 P;  3HDB A;  1PWU A;  1BSW A;  3RTT A;  2WOA A;  4WF6 A;  2N8R A;  1UMS A;  3U1R A;  3LIR A;  1PWQ A;  2V4B A;  1BIW A;  3EWJ A;  1GKD A;  3G5C A;  4ON1 A;  1QIB A;  3F16 A;  3L0T A;  1KUK A;  1K7I A;  3KME A;  2FV5 A;  1R55 A;  2J83 A;  3LE9 A;  2X7M A;  3UVC A;  2J0T A;  2L0R A;  4WKE A;  3P1V A;  2Y6D A;  2ERO A;  1KUF A;  1L6J A;  1MMQ A;  2E3X A;  1CGE A;  3HDA P;  3KHI A;  2TCL A;  1XUR A;  3F17 A;  1XUD A;  1CQR A;  4FVL A;  3TVC A;  3NX7 A;  1Z3J A;  3LGP A;  1BQO A;  1UEA A;  3LEA A;  3EDH A;  2E2D A;  4XM8 A;  1CK7 A;  2WO9 A;  1OMJ A;  1G49 A;  3O64 A;  3I7G A;  4ZR5 A;  4JP4 A;  1EAK A;  2RJP A;  3B8Z A;  4GUY A;  1MMP A;  3B92 A;  1FLS A;  1JAQ A;  3WV1 A;  2XS4 A;  2MZH A;  1XFZ A;  4PKQ A;  1CGF A;  1I76 A;  4H30 A;  4IUW A;  3TT4 A;  1IAC A;  2ERQ A;  1YQY A;  2CKI A;  3HBU P;  1K7G A;  3KRY A;  1ZXV A;  1CXV A;  4AIG A;  1PWW A;  4FU4 A;  2DW1 A;  3LMC A;  3LJG A;  1QUA A;  4J4M A;  5I43 A;  4FXQ A;  3KEJ A;  1I1I P;  1IAD A;  2USN A;  2DW0 A;  3F15 A;  3DWB A;  4I03 A;  1RMZ A;  3WV3 A;  5D1T A;  1HTD A;  2W15 A;  3HY7 A;  4PKV A;  4R3V A;  2X3B A;  1QJJ A;  1HV5 A;  4JA1 A;  1GE6 A;  3LUN A;  3E8R A;  1BKC E;  3OHO A;  1S4B P;  2W0D A;  1JAN A;  3USN A;  3LIK A;  1R1H A;  1SAT A;  4JPA A;  1G05 A;  1G9K A;  1OM6 A;  2W12 A;  1BM6 A;  2JT6 A;  3DSL A;  1ZVX A;  1USN A;  3ELM A;  1IAA A;  1B8Y A;  1JIZ A;  1KUI A;  1QIC A;  1SU3 A;  1ZXC A;  1EUB A;  1R1I A;  2A8H A;  1SLN A;  2Y6C A;  3LJT A;  5BOT A;  1A86 A;  2OXW A;  4H2E A;  1HOV A;  1BKC I;  5D1S A;  1GO8 P;  4PKU A;  3N2V A;  4GWN A;  1BUD A;  3ZUK A;  1B3D A;  5BOY A;  5L79 A;  4PKT A;  1OO9 A;  3K7N A;  1IAG A;  1AKL A;  5I2Z A;  1AYK A;  2OW0 A;  2OW9 A;  2POJ A;  1RM8 A;  1G4K A;  4ILW D;  5JMY A;  4IJO A;  1SLM A;  4XBH A;  3Q2H A;  3DPF A;  1J7N A;  1G12 A;  1QJI A;  4EFS A;  4G0D A;  966C A;  1QIA A;  5H8X A;  2MZE A;  2OVX A;  3EDG A;  1XFY A;  1PWV A;  1XFU A;  3F1A A;  1K7Q A;  1JAP A;  1R54 A;  5BPA A;  4DV8 A;  1BKC A;  1R1J A;  1BUV M;  1C8T A;  4L19 A;  3GBO A;  5I0L A;  1MMB A;  4G9L A;  3I7I A;  1UMT A;  4PKR A;  1KBC A;  2SRT A;  3VTG A;  4WK7 A;  2OW1 A;  4H3X A;  2MLR A;  3BA0 A;  2MLS A;  4PKS A;  5CXA A;  3LQB A;  4Q1L A;  3CKI A;  2XS3 A;  1PWP A;  2K2G A;  1GXD A;  1XFV A;  1KAP P;  3LK8 A;  4CTH A;  4HMA A;  3F18 A;  1Q3A A;  1YCM A;  2X3C A;  2AYK A;  1HFS A;  1CAQ A;  2FV9 A;  4L63 A;  1AST A;  1AF0 A;  1MNC A;  3LUM A;  3TSK A;  1CGL A;  3Q2G A;  3K7L A;  4GR3 A;  1ATL A;  1MMR A;  3LIL A;  4DD8 A;  3MA2 A;  4A3W A;  4FXY P;  3KMC A;  1GE7 A;  4DPE A;  2D1O A;  3EHX A;  3KEC A;  1GKC A;  1ZS0 A;  2JIH A;  3ZXH A;  2O3E A;  2OXU A;  1D5J A;  2D1N A;  3KWV C;  4HX3 A;  5I3M A;  4JQG A;  3DL1 A;  4XM7 A;  5D2B A;  2AIG P;  1OS9 A;  3L0V A;  1HY7 A;  1OM7 A;  3OHL A;  2JNP A;  2DW2 A;  2OVZ A;  3ZVS A;  1SRP A;  4IN9 A;  2OI0 A;  1JK3 A;  1OS2 A;  3N2U A;  4AYK A;  3DPE A;  3TS4 A;  2OW2 A;  2DDF A;  2OXZ A;  5CZM A;  2RJQ A;  1KUH A;  4GR8 A;  4A7B A;  1OM8 A;  1JKY A;  2DDY A;  4WKI A;  4GWM A;  1C3I A;  3F19 A;  4H1Q A;  2OZR A;  5I12 A;  1EB6 A;  1WNI A;  1CIZ A;  1XUC A;  4I35 A;  3WV2 A;  1HFC A;  1UTZ A;  4GR0 A;  1IAB A;  1ND1 A;  1O0Q A;  1JH1 A;  2QPJ A;  1JIW P;  3AYU A;  2JSD A;  5B5O A;  4L6T A;  1KUG A;  4DF9 A;  1DMT A;  1IAE A;  3AYK A;  3HB2 P;  3LKA A;  2W14 A;  2WO8 A;  1YOU A;  2YB9 A;  3G42 A;  1YP1 A;  5B5P A;  1D8F A;  4AUO A;  1Y8J A;  4H82 A;  2O36 A;  1BQQ M;  1DTH A;  5D1U A;  4GQL A;  3LQ0 A;  3HBV P;  3LJZ A;  1ROS A;  2KRJ A;  3B2Z A;  3RTS A;  2PJT A;  1JJ9 A;  456C A;  2OY2 A;  4XCT A;  1O0T A; 
#chains in the Genus database with same CATH topology
 1XFW A;  2X3A A;  1Y0V A;  1D7X A;  3HY9 A;  1I73 A;  1JAO A;  4GF1 A;  3SHI A;  1ZTQ A;  1ZP5 A;  2ERP A;  3P24 A;  1C7K A;  1UTT A;  2CLT A;  1GO7 P;  5CUH A;  3KEK A;  4H49 A;  3HYG A;  3EDI A;  4AXQ A;  2Z2D A;  2W13 A;  5I4O A;  1BZS A;  4H76 A;  1GE5 A;  4H84 A;  4WZV A;  2OY4 A;  3AIG A;  2YIG A;  4QKZ A;  2JT5 A;  2K9C A;  5D3C A;  5L7F A;  2I47 A;  3VI1 A;  1XFX A;  2MZI A;  1Y93 A;  3O2X A;  3EDZ A;  1FBL A;  5D7W A;  3V96 B;  830C A;  1A85 A;  4XM6 A;  1D8M A;  3EHY A;  1SMP A;  5LAB A;  1FM1 A;  4JIJ A;  4PKW A;  2HU6 A;  3DNG A;  1H71 P;  3HDB A;  1PWU A;  1BSW A;  3RTT A;  2WOA A;  3DTI A;  4WF6 A;  2N8R A;  1UMS A;  3U1R A;  3LIR A;  1PWQ A;  2V4B A;  1BIW A;  3EWJ A;  1GKD A;  3G5C A;  4ON1 A;  1QIB A;  3F16 A;  3L0T A;  1KUK A;  1K7I A;  3KME A;  2FV5 A;  1R55 A;  2J83 A;  3LE9 A;  2X7M A;  3UVC A;  4L7A A;  2J0T A;  2L0R A;  4WKE A;  3P1V A;  2Y6D A;  2ERO A;  1KUF A;  1L6J A;  1MMQ A;  2E3X A;  1CGE A;  3HDA P;  3KHI A;  2TCL A;  1XUR A;  3F17 A;  1XUD A;  1CQR A;  4FVL A;  3TVC A;  3NX7 A;  1Z3J A;  3LGP A;  1BQO A;  1UEA A;  3LEA A;  3EDH A;  2E2D A;  4XM8 A;  1CK7 A;  2WO9 A;  1OMJ A;  1G49 A;  3O64 A;  3I7G A;  4ZR5 A;  4JP4 A;  1EAK A;  2RJP A;  3B8Z A;  4GUY A;  1MMP A;  3B92 A;  1FLS A;  1JAQ A;  3WV1 A;  2XS4 A;  2MZH A;  1XFZ A;  4PKQ A;  1CGF A;  1I76 A;  4H30 A;  4IUW A;  3TT4 A;  1IAC A;  2ERQ A;  1YQY A;  2CKI A;  3HBU P;  1K7G A;  3KRY A;  1XAX A;  1ZXV A;  1CXV A;  4AIG A;  1PWW A;  4FU4 A;  2DW1 A;  3LMC A;  3LJG A;  1QUA A;  4J4M A;  5I43 A;  4FXQ A;  3KEJ A;  1I1I P;  1IAD A;  2USN A;  2DW0 A;  3F15 A;  3DWB A;  4I03 A;  1RMZ A;  3WV3 A;  5D1T A;  1HTD A;  2W15 A;  3HY7 A;  4PKV A;  4R3V A;  2X3B A;  1QJJ A;  1HV5 A;  4JA1 A;  1GE6 A;  3LUN A;  3E8R A;  1BKC E;  3OHO A;  1S4B P;  2W0D A;  1JAN A;  3USN A;  3LIK A;  1R1H A;  1SAT A;  4JPA A;  1G05 A;  1XM5 A;  1G9K A;  1OM6 A;  2W12 A;  1BM6 A;  2JT6 A;  3DSL A;  1ZVX A;  1USN A;  3ELM A;  1IAA A;  1B8Y A;  1JIZ A;  1KUI A;  1QIC A;  1SU3 A;  1ZXC A;  1EUB A;  1R1I A;  2A8H A;  1SLN A;  2Y6C A;  3LJT A;  5BOT A;  1A86 A;  2OXW A;  4H2E A;  1HOV A;  1BKC I;  5D1S A;  1GO8 P;  4PKU A;  3N2V A;  4GWN A;  1BUD A;  3ZUK A;  1B3D A;  5BOY A;  5L79 A;  4PKT A;  1OO9 A;  3K7N A;  1IAG A;  1AKL A;  5I2Z A;  1AYK A;  2OW0 A;  2OW9 A;  2POJ A;  1RM8 A;  1G4K A;  4ILW D;  5JMY A;  4IJO A;  1SLM A;  4XBH A;  3Q2H A;  3DPF A;  1J7N A;  1G12 A;  1QJI A;  4EFS A;  4G0D A;  966C A;  1QIA A;  5H8X A;  2MZE A;  2OVX A;  3EDG A;  1XFY A;  1PWV A;  1XFU A;  3F1A A;  1K7Q A;  1JAP A;  1R54 A;  5BPA A;  4DV8 A;  1BKC A;  1R1J A;  1BUV M;  1C8T A;  4L19 A;  3GBO A;  5I0L A;  1OZ9 A;  1MMB A;  4G9L A;  3I7I A;  1UMT A;  4PKR A;  1KBC A;  2SRT A;  3VTG A;  4WK7 A;  2OW1 A;  4H3X A;  2MLR A;  3BA0 A;  2MLS A;  4PKS A;  5CXA A;  3LQB A;  4Q1L A;  3CKI A;  2XS3 A;  1PWP A;  2K2G A;  1GXD A;  1XFV A;  1KAP P;  3LK8 A;  4CTH A;  4HMA A;  3F18 A;  1Q3A A;  1YCM A;  2X3C A;  2AYK A;  1HFS A;  1CAQ A;  2FV9 A;  4L63 A;  1AST A;  1AF0 A;  1MNC A;  3LUM A;  3TSK A;  1CGL A;  3Q2G A;  3K7L A;  4GR3 A;  1ATL A;  1MMR A;  3LIL A;  4DD8 A;  3MA2 A;  4A3W A;  4FXY P;  3KMC A;  1GE7 A;  4DPE A;  2D1O A;  3EHX A;  3DTE A;  3KEC A;  1GKC A;  1ZS0 A;  2JIH A;  3ZXH A;  2O3E A;  3DTK A;  2OXU A;  1D5J A;  2D1N A;  3KWV C;  4HX3 A;  5I3M A;  4JQG A;  3DL1 A;  4XM7 A;  5D2B A;  2YUF A;  2AIG P;  1OS9 A;  3L0V A;  1HY7 A;  1OM7 A;  3OHL A;  2JNP A;  2DW2 A;  2OVZ A;  3ZVS A;  1SRP A;  4IN9 A;  2OI0 A;  1JK3 A;  1OS2 A;  3N2U A;  4AYK A;  3DPE A;  3TS4 A;  2OW2 A;  2DDF A;  2OXZ A;  5CZM A;  2RJQ A;  1KUH A;  4GR8 A;  4A7B A;  1OM8 A;  1JKY A;  2DDY A;  4WKI A;  4GWM A;  1C3I A;  3F19 A;  4H1Q A;  2OZR A;  5I12 A;  1EB6 A;  1WNI A;  1CIZ A;  1XUC A;  4I35 A;  3WV2 A;  1HFC A;  1UTZ A;  4GR0 A;  1IAB A;  1ND1 A;  1O0Q A;  1TVI A;  1JH1 A;  2QPJ A;  1JIW P;  3AYU A;  2JSD A;  5B5O A;  4L6T A;  1KUG A;  4DF9 A;  1DMT A;  1IAE A;  3AYK A;  3HB2 P;  3LKA A;  2W14 A;  2WO8 A;  1YOU A;  2YB9 A;  3G42 A;  1YP1 A;  5B5P A;  1D8F A;  4AUO A;  1Y8J A;  4H82 A;  2O36 A;  1BQQ M;  1DTH A;  5D1U A;  4GQL A;  3LQ0 A;  3HBV P;  1ROS A;  2KRJ A;  3LJZ A;  3B2Z A;  3RTS A;  2PJT A;  1JJ9 A;  456C A;  2OY2 A;  4XCT A;  1O0T A; 
#chains in the Genus database with same CATH homology
 1XFW A;  2X3A A;  1Y0V A;  1D7X A;  3HY9 A;  1I73 A;  1JAO A;  4GF1 A;  3SHI A;  1ZTQ A;  1ZP5 A;  2ERP A;  3P24 A;  1C7K A;  1UTT A;  2CLT A;  1GO7 P;  5CUH A;  3KEK A;  4H49 A;  3HYG A;  3EDI A;  4AXQ A;  2Z2D A;  2W13 A;  5I4O A;  1BZS A;  4H76 A;  1GE5 A;  4H84 A;  4WZV A;  2OY4 A;  3AIG A;  2YIG A;  4QKZ A;  2JT5 A;  2K9C A;  5D3C A;  5L7F A;  2I47 A;  3VI1 A;  1XFX A;  2MZI A;  1Y93 A;  3O2X A;  3EDZ A;  1FBL A;  5D7W A;  3V96 B;  830C A;  1A85 A;  4XM6 A;  1D8M A;  3EHY A;  1SMP A;  5LAB A;  1FM1 A;  4JIJ A;  4PKW A;  2HU6 A;  3DNG A;  1H71 P;  3HDB A;  1PWU A;  1BSW A;  3RTT A;  2WOA A;  3DTI A;  4WF6 A;  2N8R A;  1UMS A;  3U1R A;  3LIR A;  1PWQ A;  2V4B A;  1BIW A;  3EWJ A;  1GKD A;  3G5C A;  4ON1 A;  1QIB A;  3F16 A;  3L0T A;  1KUK A;  1K7I A;  3KME A;  2FV5 A;  1R55 A;  2J83 A;  3LE9 A;  2X7M A;  3UVC A;  4L7A A;  2J0T A;  2L0R A;  4WKE A;  3P1V A;  2Y6D A;  2ERO A;  1KUF A;  1L6J A;  1MMQ A;  2E3X A;  1CGE A;  3HDA P;  3KHI A;  2TCL A;  1XUR A;  3F17 A;  1XUD A;  1CQR A;  4FVL A;  3TVC A;  3NX7 A;  1Z3J A;  3LGP A;  1BQO A;  1UEA A;  3LEA A;  3EDH A;  2E2D A;  4XM8 A;  1CK7 A;  2WO9 A;  1OMJ A;  1G49 A;  3O64 A;  3I7G A;  4ZR5 A;  4JP4 A;  1EAK A;  2RJP A;  3B8Z A;  4GUY A;  1MMP A;  3B92 A;  1FLS A;  1JAQ A;  3WV1 A;  2XS4 A;  2MZH A;  1XFZ A;  4PKQ A;  1CGF A;  1I76 A;  4H30 A;  4IUW A;  3TT4 A;  1IAC A;  2ERQ A;  1YQY A;  2CKI A;  3HBU P;  1K7G A;  3KRY A;  1ZXV A;  1CXV A;  4AIG A;  1PWW A;  4FU4 A;  2DW1 A;  3LMC A;  3LJG A;  1QUA A;  4J4M A;  5I43 A;  4FXQ A;  3KEJ A;  1I1I P;  1IAD A;  2USN A;  2DW0 A;  3F15 A;  3DWB A;  4I03 A;  1RMZ A;  3WV3 A;  5D1T A;  1HTD A;  2W15 A;  3HY7 A;  4PKV A;  4R3V A;  2X3B A;  1QJJ A;  1HV5 A;  4JA1 A;  1GE6 A;  3LUN A;  3E8R A;  1BKC E;  3OHO A;  1S4B P;  2W0D A;  1JAN A;  3USN A;  3LIK A;  1R1H A;  1SAT A;  4JPA A;  1G05 A;  1G9K A;  1OM6 A;  2W12 A;  1BM6 A;  2JT6 A;  3DSL A;  1ZVX A;  1USN A;  3ELM A;  1IAA A;  1B8Y A;  1JIZ A;  1KUI A;  1QIC A;  1SU3 A;  1ZXC A;  1EUB A;  1R1I A;  2A8H A;  1SLN A;  2Y6C A;  3LJT A;  5BOT A;  1A86 A;  2OXW A;  4H2E A;  1HOV A;  1BKC I;  5D1S A;  1GO8 P;  4PKU A;  3N2V A;  4GWN A;  1BUD A;  3ZUK A;  1B3D A;  5BOY A;  5L79 A;  4PKT A;  1OO9 A;  3K7N A;  1IAG A;  1AKL A;  5I2Z A;  1AYK A;  2OW0 A;  2OW9 A;  2POJ A;  1RM8 A;  1G4K A;  4ILW D;  5JMY A;  4IJO A;  1SLM A;  4XBH A;  3Q2H A;  3DPF A;  1J7N A;  1G12 A;  1QJI A;  4EFS A;  4G0D A;  966C A;  1QIA A;  5H8X A;  2MZE A;  2OVX A;  3EDG A;  1XFY A;  1PWV A;  1XFU A;  3F1A A;  1K7Q A;  1JAP A;  1R54 A;  5BPA A;  4DV8 A;  1BKC A;  1R1J A;  1BUV M;  1C8T A;  4L19 A;  3GBO A;  5I0L A;  1MMB A;  4G9L A;  3I7I A;  1UMT A;  4PKR A;  1KBC A;  2SRT A;  3VTG A;  4WK7 A;  2OW1 A;  4H3X A;  2MLR A;  3BA0 A;  2MLS A;  4PKS A;  5CXA A;  3LQB A;  4Q1L A;  3CKI A;  2XS3 A;  1PWP A;  2K2G A;  1GXD A;  1XFV A;  1KAP P;  3LK8 A;  4CTH A;  4HMA A;  3F18 A;  1Q3A A;  1YCM A;  2X3C A;  2AYK A;  1HFS A;  1CAQ A;  2FV9 A;  4L63 A;  1AST A;  1AF0 A;  1MNC A;  3LUM A;  3TSK A;  1CGL A;  3Q2G A;  3K7L A;  4GR3 A;  1ATL A;  1MMR A;  3LIL A;  4DD8 A;  3MA2 A;  4A3W A;  4FXY P;  3KMC A;  1GE7 A;  4DPE A;  2D1O A;  3EHX A;  3DTE A;  3KEC A;  1GKC A;  1ZS0 A;  2JIH A;  3ZXH A;  2O3E A;  3DTK A;  2OXU A;  1D5J A;  2D1N A;  3KWV C;  4HX3 A;  5I3M A;  4JQG A;  3DL1 A;  4XM7 A;  5D2B A;  2YUF A;  2AIG P;  1OS9 A;  3L0V A;  1HY7 A;  1OM7 A;  3OHL A;  2JNP A;  2DW2 A;  2OVZ A;  3ZVS A;  1SRP A;  4IN9 A;  2OI0 A;  1JK3 A;  1OS2 A;  3N2U A;  4AYK A;  3DPE A;  3TS4 A;  2OW2 A;  2DDF A;  2OXZ A;  5CZM A;  2RJQ A;  1KUH A;  4GR8 A;  4A7B A;  1OM8 A;  1JKY A;  2DDY A;  4WKI A;  4GWM A;  1C3I A;  3F19 A;  4H1Q A;  2OZR A;  5I12 A;  1EB6 A;  1WNI A;  1CIZ A;  1XUC A;  4I35 A;  3WV2 A;  1HFC A;  1UTZ A;  4GR0 A;  1IAB A;  1ND1 A;  1O0Q A;  1JH1 A;  2QPJ A;  1JIW P;  3AYU A;  2JSD A;  5B5O A;  4L6T A;  1KUG A;  4DF9 A;  1DMT A;  1IAE A;  3AYK A;  3HB2 P;  3LKA A;  2W14 A;  2WO8 A;  1YOU A;  2YB9 A;  3G42 A;  1YP1 A;  5B5P A;  1D8F A;  4AUO A;  1Y8J A;  4H82 A;  2O36 A;  1BQQ M;  1DTH A;  5D1U A;  4GQL A;  3LQ0 A;  3HBV P;  3LJZ A;  1ROS A;  2KRJ A;  3B2Z A;  3RTS A;  2PJT A;  1JJ9 A;  456C A;  2OY2 A;  4XCT A;  1O0T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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