3KZJA

Structure of complement factor h variant r1203a
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
125
structure length
125
Chain Sequence
TGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKAGYRLSSRSHTLRTTCWDGKLEYPTCAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 26
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2009-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3kzjA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3kzjA02
3KZJA 2JGWA 1OK9A 1TPNA 3IX0A 1QUBA 4PZ5A 1GHQB 3NFPI 1TPGA 1G4FA 4WJG2 2IZ4A 1Q3XA 2KMSA 1C1ZA 1QGBA 2W81A 4AYDA 1GKGA 2RKYA 4YNXA 3ERBA 1H2QP 2XRBA 2RKZA 2RL0A 1H2PP 3MQLA 1GPZA 2EHFA 2CG6A 2EC3A 1TPMA 2JGXA 5HYPA 1G4GA 4ZH1D 2W80A 1MD7A 1U5MA 2CKUA 1OJVA 1OK1A 4C16A 3GOVA 4A5WB 3CALA 3O8EB 3IU3I 4K12A 2KRIA 2QY0A 4AYEA 3R62A 1VVDA 3ZD1A 1SS2A 3SW0X 5HZPB 2WIIC 2B5ID 3EJHA 3OXUD 1E88A 1Z92B 1UOTP 4LOSA 2YBYA 4F4OC 3RJ3D 5JPMG 2G7IA 1HCCA 1PPQA 1SRZA 1LY2A 3M7PA 2UWNA 4DJZA 2YRAA 2CG7A 4LOTA 4AYMA 4AYIA 1FBRA 1OK2A 4ONTD 2JRAA 1OJYA 2XWJI 1QO6A 2A55A 4J38B 3TVJA 2RLPA 2O39C 2XQWC 1H03P 1HFHA 1E5GA 1E8BA 4JHSA 5FO8C 2IZ3A 2V8EA 4B2SA 2XRDA 2MCYA 5I0QB 3GXEA 4CSYA 4B2RA 4FXGG 1ZJKA 3KXVA 4MUCA 3ZRZA 1H04P 3INBC 5HYUB 3OEDC 1NWVA 2RLQA 1MD8A 1ELVA 2ERJA 2MCZA 1HFIA 1OJWA 2LOJA 5HYTB 1VVCA 1O9AA 4IGDA 1CKLA 1GKNA 3T5OA 3ZD2A 3OP8A 3L89M 1OK3A 4KKDA 2BZMA 2XWBF
chains in the Genus database with same CATH superfamily
3KZJA 2JGWA 3FGTA 1OK9A 1TPNA 3IX0A 1QUBA 4PO7A 4PZ5A 1GHQB 3NFPI 2Y8SA 1TPGA 1G4FA 4WJG2 2IZ4A 1Q3XA 2KMSA 1C1ZA 1QGBA 2W81A 3ZLDA 3FGRA 4AYDA 1GKGA 2RKYA 4YNXA 4N7EA 3ERBA 1H2QP 2XRBA 1RLHA 2RKZA 2RL0A 1H2PP 3MQLA 1GPZA 2EHFA 2Y8RA 2CG6A 2EC3A 3F6KA 1TPMA 2JGXA 3VWOA 5HYPA 1G4GA 4ZH1D 2W80A 4YIZA 1MD7A 1U5MA 2CKUA 1OJVA 1OK1A 3WSYA 4C16A 3GOVA 4A5WB 3CALA 3O8EB 3IU3I 4K12A 2KRIA 2QY0A 4AYEA 3R62A 1VVDA 3CI0J 3ZD1A 1SS2A 2ZYCA 3SW0X 5HZPB 2WIIC 2B5ID 2X2ZA 3EJHA 3OXUD 1E88A 1Z92B 1UOTP 4LOSA 2YBYA 4F4OC 3RJ3D 5JPMG 2G7IA 4BWCA 3ZLEA 1HCCA 1PPQA 1SRZA 4APLA 1LY2A 3M7PA 2UWNA 4DJZA 4MSLA 2YRAA 2Y8TA 2I2LA 2CG7A 4LOTA 5DN5A 4AYMA 4AYIA 1FBRA 1OK2A 4ONTD 2JRAA 1OJYA 2XWJI 1QO6A 2A55A 4J38B 3TVJA 2RLPA 2O39C 2XQWC 1H03P 1HFHA 1E5GA 1E8BA 4JHSA 5FO8C 2IZ3A 2V8EA 4B2SA 2XRDA 2MCYA 5I0QB 3GXEA 4CSYA 4B2RA 4FXGG 1ZJKA 3KXVA 4MUCA 3ZRZA 1H04P 3INBC 3WSXA 5HYUB 3OEDC 1NWVA 2RLQA 1MD8A 1ELVA 2ERJA 2MCZA 1HFIA 1OJWA 2LOJA 5DN4A 3NJAA 5HYTB 3K3TA 1VVCA 1O9AA 4IGDA 1CKLA 1GKNA 3T5OA 3ZD2A 3OP8A 3L89M 1OK3A 4KKDA 2BZMA 2XWBF
chains in the Genus database with same CATH topology
3KZJA 2JGWA 1OK9A 1TPNA 3IX0A 1QUBA 4PZ5A 1GHQB 3NFPI 1TPGA 1G4FA 4WJG2 2IZ4A 1Q3XA 2KMSA 1C1ZA 1QGBA 2W81A 4AYDA 1GKGA 2RKYA 4YNXA 3ERBA 1H2QP 2XRBA 2RKZA 2RL0A 1H2PP 3MQLA 1GPZA 2EHFA 2CG6A 2EC3A 1TPMA 2JGXA 5HYPA 1G4GA 4ZH1D 2W80A 1MD7A 1U5MA 2CKUA 1OJVA 1OK1A 4C16A 3GOVA 4A5WB 3CALA 3O8EB 3IU3I 4K12A 2KRIA 2QY0A 4AYEA 3R62A 1VVDA 3ZD1A 1SS2A 3SW0X 5HZPB 2WIIC 2B5ID 3EJHA 3OXUD 1E88A 1Z92B 1UOTP 4LOSA 2YBYA 4F4OC 3RJ3D 5JPMG 2G7IA 1HCCA 1PPQA 1SRZA 1LY2A 3M7PA 2UWNA 4DJZA 2YRAA 2CG7A 4LOTA 4AYMA 4AYIA 1FBRA 1OK2A 4ONTD 2JRAA 1OJYA 2XWJI 1QO6A 2A55A 4J38B 3TVJA 2RLPA 2O39C 2XQWC 1H03P 1HFHA 1E5GA 1E8BA 4JHSA 5FO8C 2IZ3A 2V8EA 4B2SA 2XRDA 2MCYA 5I0QB 3GXEA 4CSYA 4B2RA 4FXGG 1ZJKA 3KXVA 4MUCA 3ZRZA 1H04P 3INBC 5HYUB 3OEDC 1NWVA 2RLQA 1MD8A 1ELVA 2ERJA 2MCZA 1HFIA 1OJWA 2LOJA 5HYTB 1VVCA 1O9AA 4IGDA 1CKLA 1GKNA 3T5OA 3ZD2A 3OP8A 3L89M 1OK3A 4KKDA 2BZMA 2XWBF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KZJ A;  2JGW A;  1OK9 A;  1TPN A;  3IX0 A;  1QUB A;  4PZ5 A;  1GHQ B;  3NFP I;  1TPG A;  1G4F A;  4WJG 2;  2IZ4 A;  1Q3X A;  2KMS A;  1C1Z A;  1QGB A;  2W81 A;  4AYD A;  1GKG A;  2RKY A;  4YNX A;  3ERB A;  1H2Q P;  2XRB A;  2RKZ A;  2RL0 A;  1H2P P;  3MQL A;  1GPZ A;  2EHF A;  2CG6 A;  2EC3 A;  1TPM A;  2JGX A;  5HYP A;  1G4G A;  4ZH1 D;  2W80 A;  1MD7 A;  1U5M A;  2CKU A;  1OJV A;  1OK1 A;  4C16 A;  3GOV A;  4A5W B;  3CAL A;  3O8E B;  3IU3 I;  4K12 A;  2KRI A;  2QY0 A;  4AYE A;  3R62 A;  1VVD A;  3ZD1 A;  1SS2 A;  3SW0 X;  5HZP B;  2WII C;  2B5I D;  3EJH A;  3OXU D;  1E88 A;  1Z92 B;  1UOT P;  4LOS A;  2YBY A;  4F4O C;  3RJ3 D;  5JPM G;  2G7I A;  1HCC A;  1PPQ A;  1SRZ A;  1LY2 A;  3M7P A;  2UWN A;  4DJZ A;  2YRA A;  2CG7 A;  4LOT A;  4AYM A;  4AYI A;  1FBR A;  1OK2 A;  4ONT D;  2JRA A;  1OJY A;  2XWJ I;  1QO6 A;  2A55 A;  4J38 B;  3TVJ A;  2RLP A;  2O39 C;  2XQW C;  1H03 P;  1HFH A;  1E5G A;  1E8B A;  4JHS A;  5FO8 C;  2IZ3 A;  2V8E A;  4B2S A;  2XRD A;  2MCY A;  5I0Q B;  3GXE A;  4CSY A;  4B2R A;  4FXG G;  1ZJK A;  3KXV A;  4MUC A;  3ZRZ A;  1H04 P;  3INB C;  5HYU B;  3OED C;  1NWV A;  2RLQ A;  1MD8 A;  1ELV A;  2ERJ A;  2MCZ A;  1HFI A;  1OJW A;  2LOJ A;  5HYT B;  1VVC A;  1O9A A;  4IGD A;  1CKL A;  1GKN A;  3T5O A;  3ZD2 A;  3OP8 A;  3L89 M;  1OK3 A;  4KKD A;  2BZM A;  2XWB F; 
#chains in the Genus database with same CATH topology
 3KZJ A;  2JGW A;  3FGT A;  1OK9 A;  1TPN A;  3IX0 A;  1QUB A;  4PO7 A;  4PZ5 A;  1GHQ B;  3NFP I;  2Y8S A;  1TPG A;  1G4F A;  4WJG 2;  2IZ4 A;  1Q3X A;  2KMS A;  1C1Z A;  1QGB A;  2W81 A;  3ZLD A;  3FGR A;  4AYD A;  1GKG A;  2RKY A;  4YNX A;  4N7E A;  3ERB A;  1H2Q P;  2XRB A;  1RLH A;  2RKZ A;  2RL0 A;  1H2P P;  3MQL A;  1GPZ A;  2EHF A;  2Y8R A;  2CG6 A;  2EC3 A;  3F6K A;  1TPM A;  2JGX A;  3VWO A;  5HYP A;  1G4G A;  4ZH1 D;  2W80 A;  4YIZ A;  1MD7 A;  1U5M A;  2CKU A;  1OJV A;  1OK1 A;  3WSY A;  4C16 A;  3GOV A;  4A5W B;  3CAL A;  3O8E B;  3IU3 I;  4K12 A;  2KRI A;  2QY0 A;  4AYE A;  3R62 A;  1VVD A;  3CI0 J;  3ZD1 A;  1SS2 A;  2ZYC A;  3SW0 X;  5HZP B;  2WII C;  2B5I D;  2X2Z A;  3EJH A;  3OXU D;  1E88 A;  1Z92 B;  1UOT P;  4LOS A;  2YBY A;  4F4O C;  3RJ3 D;  5JPM G;  2G7I A;  4BWC A;  3ZLE A;  1HCC A;  1PPQ A;  1SRZ A;  4APL A;  1LY2 A;  3M7P A;  2UWN A;  4DJZ A;  4MSL A;  2YRA A;  2Y8T A;  2I2L A;  2CG7 A;  4LOT A;  5DN5 A;  4AYM A;  4AYI A;  1FBR A;  1OK2 A;  4ONT D;  2JRA A;  1OJY A;  2XWJ I;  1QO6 A;  2A55 A;  4J38 B;  3TVJ A;  2RLP A;  2O39 C;  2XQW C;  1H03 P;  1HFH A;  1E5G A;  1E8B A;  4JHS A;  5FO8 C;  2IZ3 A;  2V8E A;  4B2S A;  2XRD A;  2MCY A;  5I0Q B;  3GXE A;  4CSY A;  4B2R A;  4FXG G;  1ZJK A;  3KXV A;  4MUC A;  3ZRZ A;  1H04 P;  3INB C;  3WSX A;  5HYU B;  3OED C;  1NWV A;  2RLQ A;  1MD8 A;  1ELV A;  2ERJ A;  2MCZ A;  1HFI A;  1OJW A;  2LOJ A;  5DN4 A;  3NJA A;  5HYT B;  3K3T A;  1VVC A;  1O9A A;  4IGD A;  1CKL A;  1GKN A;  3T5O A;  3ZD2 A;  3OP8 A;  3L89 M;  1OK3 A;  4KKD A;  2BZM A;  2XWB F; 
#chains in the Genus database with same CATH homology
 3KZJ A;  2JGW A;  1OK9 A;  1TPN A;  3IX0 A;  1QUB A;  4PZ5 A;  1GHQ B;  3NFP I;  1TPG A;  1G4F A;  4WJG 2;  2IZ4 A;  1Q3X A;  2KMS A;  1C1Z A;  1QGB A;  2W81 A;  4AYD A;  1GKG A;  2RKY A;  4YNX A;  3ERB A;  1H2Q P;  2XRB A;  2RKZ A;  2RL0 A;  1H2P P;  3MQL A;  1GPZ A;  2EHF A;  2CG6 A;  2EC3 A;  1TPM A;  2JGX A;  5HYP A;  1G4G A;  4ZH1 D;  2W80 A;  1MD7 A;  1U5M A;  2CKU A;  1OJV A;  1OK1 A;  4C16 A;  3GOV A;  4A5W B;  3CAL A;  3O8E B;  3IU3 I;  4K12 A;  2KRI A;  2QY0 A;  4AYE A;  3R62 A;  1VVD A;  3ZD1 A;  1SS2 A;  3SW0 X;  5HZP B;  2WII C;  2B5I D;  3EJH A;  3OXU D;  1E88 A;  1Z92 B;  1UOT P;  4LOS A;  2YBY A;  4F4O C;  3RJ3 D;  5JPM G;  2G7I A;  1HCC A;  1PPQ A;  1SRZ A;  1LY2 A;  3M7P A;  2UWN A;  4DJZ A;  2YRA A;  2CG7 A;  4LOT A;  4AYM A;  4AYI A;  1FBR A;  1OK2 A;  4ONT D;  2JRA A;  1OJY A;  2XWJ I;  1QO6 A;  2A55 A;  4J38 B;  3TVJ A;  2RLP A;  2O39 C;  2XQW C;  1H03 P;  1HFH A;  1E5G A;  1E8B A;  4JHS A;  5FO8 C;  2IZ3 A;  2V8E A;  4B2S A;  2XRD A;  2MCY A;  5I0Q B;  3GXE A;  4CSY A;  4B2R A;  4FXG G;  1ZJK A;  3KXV A;  4MUC A;  3ZRZ A;  1H04 P;  3INB C;  5HYU B;  3OED C;  1NWV A;  2RLQ A;  1MD8 A;  1ELV A;  2ERJ A;  2MCZ A;  1HFI A;  1OJW A;  2LOJ A;  5HYT B;  1VVC A;  1O9A A;  4IGD A;  1CKL A;  1GKN A;  3T5O A;  3ZD2 A;  3OP8 A;  3L89 M;  1OK3 A;  4KKD A;  2BZM A;  2XWB F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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