3L24A

Crystal structure of the nerve agent degrading organophosphate anhydrolase/prolidase in complex with inhibitors
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
440
structure length
425
Chain Sequence
MNKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVPDEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMALRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELRLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
total genus 148
structure length 425
sequence length 440
chains with identical sequence B, C
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2009-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 3l24A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3l24A02
2GG5A 1CHMA 4QR8A 3Q6DA 4Z7MA 4U76A 2BHAA 2BN7A 4IKSA 4U6CA 1XGNA 3MX6A 5CLSA 1XGMA 4JUQA 3IG4A 3IU8A 2BH3A 4PV4A 3IU7A 1C23A 1KQ0A 1N51A 2P99A 1QXYA 1B6AA 1YW9A 3S6BA 4B28A 4S2RP 3FMQA 3TAVA 5CNXA 2BHCA 3L24A 1WY2A 2Q93A 1PV9A 2NQ7A 2NQ6A 4IDYA 2BWUA 3MR1A 1WBQA 3BIQA 2GG0A 2BWWA 1MATA 1W2MA 5E2CA 3I7MA 3O5VA 1WLRA 4IKTA 4IECA 5D6FA 4IU6A 4U6ZA 2GG8A 4U73A 4RGZ1 4R60A 3RORA 4S01A 4S00A 4S2TP 1O0XA 1QXZA 2G6PA 2P9AA 2B3LA 3RVAA 4FLKA 1M35A 2Q92A 3IU9A 4MATA 2Q95A 4IKRA 4ZWPA 2EVMA 5D6EA 4U6JA 2ADUA 4IKUA 1YW8A 4U6WA 3BIPA 1R5GA 2OKNA 2EVCA 3PKAA 5JHUA 1YW7A 3BITA 2GU4A 4IF7A 4ZNGA 1WN1A 4EGEA 5E5BA 2OAZA 2EA4A 2ZSGA 3PEBA 1BN5A 4OOKA 4HXXA 3FM3A 4U69A 2BWTA 2BWSA 4ZWUA 4FUKA 1YJ3A 2GG7A 3PKEA 2GU7A 1KP0A 3IL0A 1QXWA 3CB5A 4FLJA 2IW2A 5CIKA 2B3KA 2GG9A 2GA2A 4FO8A 4A6WA 4U6EA 3L7GA 3TB5A 5FCHA 1KQ9A 4KM3A 3PKBA 4FO7A 2V3XA 2V3YA 4FLLA 2V6CA 5CE6A 1QZYA 2DFIA 2EVOA 2GU6A 1XGOA 1JAWA 3CTZA 3PKDA 2EA2A 2GZ5A 2GG3A 4FLIA 3FMRA 1YVMA 2Q96A 5CDEA 5JI6A 1BOAA 4RZZA 2Q94A 1C21A 3PKCA 3MATA 4U70A 2BHBA 1WL6A 3D27A 1XGSA 1Y1NA 2Q8KA 5CDLA 4A6VA 2BWVA 3QOCA 3CB6A 4ZWOA 1B59A 2P98A 1R58A 4RZYA 4U75A 1WL9A 3OOOA 2V3ZA 2GGBA 2BB7A 2GGCA 2BWYA 1W7VA 1C27A 2GTXA 4PNCA 4U71A 2BHDA 2B3HA 1C24A 1R5HA 2MATA 4FKCA 3OVKA 2GG2A 1WKMA 1XNZA 4U1BA 5JFRA 1A16A 5FCFA 5CDVA 1C22A 4IPAA 2BWXA 2GU5A 3PN9A 2HOWA
chains in the Genus database with same CATH superfamily
2GG5A 1CHMA 4QR8A 3Q6DA 4Z7MA 4U76A 2BHAA 2BN7A 4IKSA 4U6CA 1XGNA 3MX6A 5CLSA 1XGMA 4JUQA 3IG4A 3IU8A 2BH3A 4PV4A 3IU7A 1C23A 1KQ0A 1N51A 2P99A 1QXYA 1B6AA 1YW9A 3S6BA 4B28A 4S2RP 3FMQA 3TAVA 5CNXA 2BHCA 3L24A 1WY2A 2Q93A 1PV9A 2NQ7A 2NQ6A 4IDYA 2BWUA 3MR1A 1WBQA 3BIQA 2GG0A 2BWWA 1MATA 1W2MA 5E2CA 3I7MA 3O5VA 1WLRA 4IKTA 4IECA 5D6FA 4IU6A 4U6ZA 2GG8A 4U73A 4RGZ1 4R60A 3RORA 4S01A 4S00A 4S2TP 1O0XA 1QXZA 2G6PA 2P9AA 2B3LA 3RVAA 4FLKA 1M35A 2Q92A 3IU9A 4MATA 2Q95A 4IKRA 4ZWPA 2EVMA 5D6EA 4U6JA 2ADUA 4IKUA 1YW8A 4U6WA 3BIPA 1R5GA 2OKNA 2EVCA 3PKAA 5JHUA 1YW7A 3BITA 2GU4A 4IF7A 4ZNGA 1WN1A 4EGEA 5E5BA 2OAZA 2EA4A 2ZSGA 3PEBA 1BN5A 4OOKA 4HXXA 3FM3A 4U69A 2BWTA 2BWSA 4ZWUA 4FUKA 1YJ3A 2GG7A 3PKEA 2GU7A 1KP0A 3IL0A 1QXWA 3CB5A 4FLJA 2IW2A 5CIKA 2B3KA 2GG9A 2GA2A 4FO8A 4A6WA 4U6EA 3L7GA 3TB5A 5FCHA 1KQ9A 4KM3A 3PKBA 4FO7A 2V3XA 2V3YA 4FLLA 2V6CA 5CE6A 1QZYA 2DFIA 2EVOA 2GU6A 1XGOA 1JAWA 3CTZA 3PKDA 2EA2A 2GZ5A 2GG3A 4FLIA 3FMRA 1YVMA 2Q96A 5CDEA 5JI6A 1BOAA 4RZZA 2Q94A 1C21A 3PKCA 3MATA 4U70A 2BHBA 1WL6A 3D27A 1XGSA 1Y1NA 2Q8KA 5CDLA 4A6VA 2BWVA 3QOCA 3CB6A 4ZWOA 1B59A 2P98A 1R58A 4RZYA 4U75A 1WL9A 3OOOA 2V3ZA 2GGBA 2BB7A 2GGCA 2BWYA 1W7VA 1C27A 2GTXA 4PNCA 4U71A 2BHDA 2B3HA 1C24A 1R5HA 2MATA 4FKCA 3OVKA 2GG2A 1WKMA 1XNZA 4U1BA 5JFRA 1A16A 5FCFA 5CDVA 1C22A 4IPAA 2BWXA 2GU5A 3PN9A 2HOWA
chains in the Genus database with same CATH topology
2GG5A 1CHMA 4QR8A 3Q6DA 4Z7MA 4U76A 2BHAA 2BN7A 4IKSA 4U6CA 1XGNA 3MX6A 5CLSA 1XGMA 4JUQA 3IG4A 3IU8A 2BH3A 4PV4A 3IU7A 1C23A 1KQ0A 1N51A 2P99A 1QXYA 1B6AA 1YW9A 3S6BA 4B28A 4S2RP 3FMQA 3TAVA 5CNXA 2BHCA 3L24A 1WY2A 2Q93A 1PV9A 2NQ7A 2NQ6A 4IDYA 2BWUA 3MR1A 1WBQA 3BIQA 2GG0A 2BWWA 1MATA 1W2MA 5E2CA 3I7MA 3O5VA 1WLRA 4IKTA 4IECA 5D6FA 4IU6A 4U6ZA 2GG8A 4U73A 4RGZ1 4R60A 3RORA 4S01A 4S00A 4S2TP 1O0XA 1QXZA 2G6PA 2P9AA 2B3LA 3RVAA 4FLKA 1M35A 2Q92A 3IU9A 4MATA 2Q95A 4IKRA 4ZWPA 2EVMA 5D6EA 4U6JA 2ADUA 4IKUA 1YW8A 4U6WA 3BIPA 1R5GA 2OKNA 2EVCA 3PKAA 5JHUA 1YW7A 3BITA 2GU4A 4IF7A 4ZNGA 1WN1A 4EGEA 5E5BA 2OAZA 2EA4A 2ZSGA 3PEBA 1BN5A 4OOKA 4HXXA 3FM3A 4U69A 2BWTA 2BWSA 4ZWUA 4FUKA 1YJ3A 2GG7A 3PKEA 2GU7A 1KP0A 3IL0A 1QXWA 3CB5A 4FLJA 2IW2A 5CIKA 2B3KA 2GG9A 2GA2A 4FO8A 4A6WA 4U6EA 3L7GA 3TB5A 5FCHA 1KQ9A 4KM3A 3PKBA 4FO7A 2V3XA 2V3YA 4FLLA 2V6CA 5CE6A 1QZYA 2DFIA 2EVOA 2GU6A 1XGOA 1JAWA 3CTZA 3PKDA 2EA2A 2GZ5A 2GG3A 4FLIA 3FMRA 1YVMA 2Q96A 5CDEA 5JI6A 1BOAA 4RZZA 2Q94A 1C21A 3PKCA 3MATA 4U70A 2BHBA 1WL6A 3D27A 1XGSA 1Y1NA 2Q8KA 5CDLA 4A6VA 2BWVA 3QOCA 3CB6A 4ZWOA 1B59A 2P98A 1R58A 4RZYA 4U75A 1WL9A 3OOOA 2V3ZA 2GGBA 2BB7A 2GGCA 2BWYA 1W7VA 1C27A 2GTXA 4PNCA 4U71A 2BHDA 2B3HA 1C24A 1R5HA 2MATA 4FKCA 3OVKA 2GG2A 1WKMA 1XNZA 4U1BA 5JFRA 1A16A 5FCFA 5CDVA 1C22A 4IPAA 2BWXA 2GU5A 3PN9A 2HOWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GG5 A;  1CHM A;  4QR8 A;  3Q6D A;  4Z7M A;  4U76 A;  2BHA A;  2BN7 A;  4IKS A;  4U6C A;  1XGN A;  3MX6 A;  5CLS A;  1XGM A;  4JUQ A;  3IG4 A;  3IU8 A;  2BH3 A;  4PV4 A;  3IU7 A;  1C23 A;  1KQ0 A;  1N51 A;  2P99 A;  1QXY A;  1B6A A;  1YW9 A;  3S6B A;  4B28 A;  4S2R P;  3FMQ A;  3TAV A;  5CNX A;  2BHC A;  3L24 A;  1WY2 A;  2Q93 A;  1PV9 A;  2NQ7 A;  2NQ6 A;  4IDY A;  2BWU A;  3MR1 A;  1WBQ A;  3BIQ A;  2GG0 A;  2BWW A;  1MAT A;  1W2M A;  5E2C A;  3I7M A;  3O5V A;  1WLR A;  4IKT A;  4IEC A;  5D6F A;  4IU6 A;  4U6Z A;  2GG8 A;  4U73 A;  4RGZ 1;  4R60 A;  3ROR A;  4S01 A;  4S00 A;  4S2T P;  1O0X A;  1QXZ A;  2G6P A;  2P9A A;  2B3L A;  3RVA A;  4FLK A;  1M35 A;  2Q92 A;  3IU9 A;  4MAT A;  2Q95 A;  4IKR A;  4ZWP A;  2EVM A;  5D6E A;  4U6J A;  2ADU A;  4IKU A;  1YW8 A;  4U6W A;  3BIP A;  1R5G A;  2OKN A;  2EVC A;  3PKA A;  5JHU A;  1YW7 A;  3BIT A;  2GU4 A;  4IF7 A;  4ZNG A;  1WN1 A;  4EGE A;  5E5B A;  2OAZ A;  2EA4 A;  2ZSG A;  3PEB A;  1BN5 A;  4OOK A;  4HXX A;  3FM3 A;  4U69 A;  2BWT A;  2BWS A;  4ZWU A;  4FUK A;  1YJ3 A;  2GG7 A;  3PKE A;  2GU7 A;  1KP0 A;  3IL0 A;  1QXW A;  3CB5 A;  4FLJ A;  2IW2 A;  5CIK A;  2B3K A;  2GG9 A;  2GA2 A;  4FO8 A;  4A6W A;  4U6E A;  3L7G A;  3TB5 A;  5FCH A;  1KQ9 A;  4KM3 A;  3PKB A;  4FO7 A;  2V3X A;  2V3Y A;  4FLL A;  2V6C A;  5CE6 A;  1QZY A;  2DFI A;  2EVO A;  2GU6 A;  1XGO A;  1JAW A;  3CTZ A;  3PKD A;  2EA2 A;  2GZ5 A;  2GG3 A;  4FLI A;  3FMR A;  1YVM A;  2Q96 A;  5CDE A;  5JI6 A;  1BOA A;  4RZZ A;  2Q94 A;  1C21 A;  3PKC A;  3MAT A;  4U70 A;  2BHB A;  1WL6 A;  3D27 A;  1XGS A;  1Y1N A;  2Q8K A;  5CDL A;  4A6V A;  2BWV A;  3QOC A;  3CB6 A;  4ZWO A;  1B59 A;  2P98 A;  1R58 A;  4RZY A;  4U75 A;  1WL9 A;  3OOO A;  2V3Z A;  2GGB A;  2BB7 A;  2GGC A;  2BWY A;  1W7V A;  1C27 A;  2GTX A;  4PNC A;  4U71 A;  2BHD A;  2B3H A;  1C24 A;  1R5H A;  2MAT A;  4FKC A;  3OVK A;  2GG2 A;  1WKM A;  1XNZ A;  4U1B A;  5JFR A;  1A16 A;  5FCF A;  5CDV A;  1C22 A;  4IPA A;  2BWX A;  2GU5 A;  3PN9 A;  2HOW A; 
#chains in the Genus database with same CATH topology
 2GG5 A;  1CHM A;  4QR8 A;  3Q6D A;  4Z7M A;  4U76 A;  2BHA A;  2BN7 A;  4IKS A;  4U6C A;  1XGN A;  3MX6 A;  5CLS A;  1XGM A;  4JUQ A;  3IG4 A;  3IU8 A;  2BH3 A;  4PV4 A;  3IU7 A;  1C23 A;  1KQ0 A;  1N51 A;  2P99 A;  1QXY A;  1B6A A;  1YW9 A;  3S6B A;  4B28 A;  4S2R P;  3FMQ A;  3TAV A;  5CNX A;  2BHC A;  3L24 A;  1WY2 A;  2Q93 A;  1PV9 A;  2NQ7 A;  2NQ6 A;  4IDY A;  2BWU A;  3MR1 A;  1WBQ A;  3BIQ A;  2GG0 A;  2BWW A;  1MAT A;  1W2M A;  5E2C A;  3I7M A;  3O5V A;  1WLR A;  4IKT A;  4IEC A;  5D6F A;  4IU6 A;  4U6Z A;  2GG8 A;  4U73 A;  4RGZ 1;  4R60 A;  3ROR A;  4S01 A;  4S00 A;  4S2T P;  1O0X A;  1QXZ A;  2G6P A;  2P9A A;  2B3L A;  3RVA A;  4FLK A;  1M35 A;  2Q92 A;  3IU9 A;  4MAT A;  2Q95 A;  4IKR A;  4ZWP A;  2EVM A;  5D6E A;  4U6J A;  2ADU A;  4IKU A;  1YW8 A;  4U6W A;  3BIP A;  1R5G A;  2OKN A;  2EVC A;  3PKA A;  5JHU A;  1YW7 A;  3BIT A;  2GU4 A;  4IF7 A;  4ZNG A;  1WN1 A;  4EGE A;  5E5B A;  2OAZ A;  2EA4 A;  2ZSG A;  3PEB A;  1BN5 A;  4OOK A;  4HXX A;  3FM3 A;  4U69 A;  2BWT A;  2BWS A;  4ZWU A;  4FUK A;  1YJ3 A;  2GG7 A;  3PKE A;  2GU7 A;  1KP0 A;  3IL0 A;  1QXW A;  3CB5 A;  4FLJ A;  2IW2 A;  5CIK A;  2B3K A;  2GG9 A;  2GA2 A;  4FO8 A;  4A6W A;  4U6E A;  3L7G A;  3TB5 A;  5FCH A;  1KQ9 A;  4KM3 A;  3PKB A;  4FO7 A;  2V3X A;  2V3Y A;  4FLL A;  2V6C A;  5CE6 A;  1QZY A;  2DFI A;  2EVO A;  2GU6 A;  1XGO A;  1JAW A;  3CTZ A;  3PKD A;  2EA2 A;  2GZ5 A;  2GG3 A;  4FLI A;  3FMR A;  1YVM A;  2Q96 A;  5CDE A;  5JI6 A;  1BOA A;  4RZZ A;  2Q94 A;  1C21 A;  3PKC A;  3MAT A;  4U70 A;  2BHB A;  1WL6 A;  3D27 A;  1XGS A;  1Y1N A;  2Q8K A;  5CDL A;  4A6V A;  2BWV A;  3QOC A;  3CB6 A;  4ZWO A;  1B59 A;  2P98 A;  1R58 A;  4RZY A;  4U75 A;  1WL9 A;  3OOO A;  2V3Z A;  2GGB A;  2BB7 A;  2GGC A;  2BWY A;  1W7V A;  1C27 A;  2GTX A;  4PNC A;  4U71 A;  2BHD A;  2B3H A;  1C24 A;  1R5H A;  2MAT A;  4FKC A;  3OVK A;  2GG2 A;  1WKM A;  1XNZ A;  4U1B A;  5JFR A;  1A16 A;  5FCF A;  5CDV A;  1C22 A;  4IPA A;  2BWX A;  2GU5 A;  3PN9 A;  2HOW A; 
#chains in the Genus database with same CATH homology
 2GG5 A;  1CHM A;  4QR8 A;  3Q6D A;  4Z7M A;  4U76 A;  2BHA A;  2BN7 A;  4IKS A;  4U6C A;  1XGN A;  3MX6 A;  5CLS A;  1XGM A;  4JUQ A;  3IG4 A;  3IU8 A;  2BH3 A;  4PV4 A;  3IU7 A;  1C23 A;  1KQ0 A;  1N51 A;  2P99 A;  1QXY A;  1B6A A;  1YW9 A;  3S6B A;  4B28 A;  4S2R P;  3FMQ A;  3TAV A;  5CNX A;  2BHC A;  3L24 A;  1WY2 A;  2Q93 A;  1PV9 A;  2NQ7 A;  2NQ6 A;  4IDY A;  2BWU A;  3MR1 A;  1WBQ A;  3BIQ A;  2GG0 A;  2BWW A;  1MAT A;  1W2M A;  5E2C A;  3I7M A;  3O5V A;  1WLR A;  4IKT A;  4IEC A;  5D6F A;  4IU6 A;  4U6Z A;  2GG8 A;  4U73 A;  4RGZ 1;  4R60 A;  3ROR A;  4S01 A;  4S00 A;  4S2T P;  1O0X A;  1QXZ A;  2G6P A;  2P9A A;  2B3L A;  3RVA A;  4FLK A;  1M35 A;  2Q92 A;  3IU9 A;  4MAT A;  2Q95 A;  4IKR A;  4ZWP A;  2EVM A;  5D6E A;  4U6J A;  2ADU A;  4IKU A;  1YW8 A;  4U6W A;  3BIP A;  1R5G A;  2OKN A;  2EVC A;  3PKA A;  5JHU A;  1YW7 A;  3BIT A;  2GU4 A;  4IF7 A;  4ZNG A;  1WN1 A;  4EGE A;  5E5B A;  2OAZ A;  2EA4 A;  2ZSG A;  3PEB A;  1BN5 A;  4OOK A;  4HXX A;  3FM3 A;  4U69 A;  2BWT A;  2BWS A;  4ZWU A;  4FUK A;  1YJ3 A;  2GG7 A;  3PKE A;  2GU7 A;  1KP0 A;  3IL0 A;  1QXW A;  3CB5 A;  4FLJ A;  2IW2 A;  5CIK A;  2B3K A;  2GG9 A;  2GA2 A;  4FO8 A;  4A6W A;  4U6E A;  3L7G A;  3TB5 A;  5FCH A;  1KQ9 A;  4KM3 A;  3PKB A;  4FO7 A;  2V3X A;  2V3Y A;  4FLL A;  2V6C A;  5CE6 A;  1QZY A;  2DFI A;  2EVO A;  2GU6 A;  1XGO A;  1JAW A;  3CTZ A;  3PKD A;  2EA2 A;  2GZ5 A;  2GG3 A;  4FLI A;  3FMR A;  1YVM A;  2Q96 A;  5CDE A;  5JI6 A;  1BOA A;  4RZZ A;  2Q94 A;  1C21 A;  3PKC A;  3MAT A;  4U70 A;  2BHB A;  1WL6 A;  3D27 A;  1XGS A;  1Y1N A;  2Q8K A;  5CDL A;  4A6V A;  2BWV A;  3QOC A;  3CB6 A;  4ZWO A;  1B59 A;  2P98 A;  1R58 A;  4RZY A;  4U75 A;  1WL9 A;  3OOO A;  2V3Z A;  2GGB A;  2BB7 A;  2GGC A;  2BWY A;  1W7V A;  1C27 A;  2GTX A;  4PNC A;  4U71 A;  2BHD A;  2B3H A;  1C24 A;  1R5H A;  2MAT A;  4FKC A;  3OVK A;  2GG2 A;  1WKM A;  1XNZ A;  4U1B A;  5JFR A;  1A16 A;  5FCF A;  5CDV A;  1C22 A;  4IPA A;  2BWX A;  2GU5 A;  3PN9 A;  2HOW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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