3L24A

Crystal structure of the nerve agent degrading organophosphate anhydrolase/prolidase in complex with inhibitors
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
440
structure length
425
Chain Sequence
b'MNKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVPDEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMALRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELRLR'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Xaa-Pro dipeptidase
publication title Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 148
structure length 425
sequence length 440
chains with identical sequence B, C
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2009-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 3l24A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3l24A02
4FKCA 2BB7A 2EVMA 3PKDA 4A6VA 3Q6DA 2EVOA 2GA2A 2GG7A 3FMQA 1XNZA 1YJ3A 4OOKA 5CDLA 3D27A 5CIKA 3FMRA 5E2CA 2GG9A 4S2RP 2BWVA 4U75A 2BHDA 1WL9A 3BIPA 2BHCA 3MATA 4S00A 1WKMA 2GG0A 4U73A 4QR8A 2B3KA 2BHAA 1YW9A 2EVCA 4JUQA 4ZWOA 5CDVA 2MATA 1R5HA 1YW7A 1YW8A 1M35A 2BWWA 2GGCA 2BWTA 4IF7A 4U6EA 2GU7A 1QXYA 2Q8KA 4Z7MA 3RVAA 2P98A 3PKAA 5CE6A 4EGEA 5JHUA 2B3HA 1W7VA 2B3LA 4U76A 2P9AA 4FLJA 2GU4A 1WN1A 2Q93A 3MR1A 3PKEA 2GTXA 4U6ZA 1C24A 3I7MA 1C27A 4ZNGA 3PKBA 2OAZA 3MX6A 1KQ9A 2BHBA 2GZ5A 2IW2A 3L24A 4RZZA 5D6EA 1R5GA 1XGSA 2EA4A 1A16A 4FLKA 2V6CA 3PEBA 4IPAA 4U69A 4S2TP 3S6BA 5JI6A 4RGZ1 1C22A 4MATA 1WBQA 1XGNA 3IU7A 3BITA 1B6AA 1C21A 1WLRA 4B28A 2Q94A 4FLLA 3IU8A 4FUKA 2V3YA 5CNXA 2ADUA 2NQ6A 2OKNA 1QZYA 2G6PA 2GU6A 3TAVA 2V3XA 3CB5A 2GG8A 4ZWPA 4U71A 2BWYA 5FCHA 5E5BA 1YVMA 1CHMA 1N51A 3PKCA 2NQ7A 4FO7A 3OOOA 4U6WA 4R60A 1W2MA 5D6FA 2P99A 2Q92A 1R58A 4IKUA 1Y1NA 5FCFA 1WL6A 3BIQA 1XGMA 3QOCA 4FO8A 1BOAA 1XGOA 3CB6A 3IU9A 3IG4A 4IKSA 4PNCA 4S01A 3CTZA 2BWXA 1KQ0A 1BN5A 3IL0A 2DFIA 2GG5A 4PV4A 4IDYA 1KP0A 4U1BA 1O0XA 2Q96A 3RORA 4RZYA 1JAWA 1PV9A 2HOWA 2BN7A 1C23A 2Q95A 4U6CA 3TB5A 4U70A 5JFRA 1QXWA 2ZSGA 2BWUA 4FLIA 2GG2A 4ZWUA 5CDEA 3OVKA 3PN9A 1MATA 2GU5A 3O5VA 1B59A 2GG3A 2BWSA 2BH3A 2EA2A 4HXXA 4IKTA 4A6WA 4IU6A 2V3ZA 3FM3A 4IECA 3L7GA 5CLSA 1WY2A 4IKRA 4KM3A 4U6JA 2GGBA 1QXZA
chains in the Genus database with same CATH superfamily
4FKCA 2BB7A 2EVMA 3PKDA 4A6VA 3Q6DA 2EVOA 2GA2A 2GG7A 3FMQA 1XNZA 1YJ3A 4OOKA 5CDLA 3D27A 5CIKA 3FMRA 5E2CA 2GG9A 4S2RP 2BWVA 4U75A 2BHDA 1WL9A 3BIPA 2BHCA 3MATA 4S00A 1WKMA 2GG0A 4U73A 4QR8A 2B3KA 2BHAA 1YW9A 2EVCA 4JUQA 4ZWOA 5CDVA 2MATA 1R5HA 1YW7A 1YW8A 1M35A 2BWWA 2GGCA 2BWTA 4IF7A 4U6EA 2GU7A 1QXYA 2Q8KA 4Z7MA 3RVAA 2P98A 3PKAA 5CE6A 4EGEA 5JHUA 2B3HA 1W7VA 2B3LA 4U76A 2P9AA 4FLJA 2GU4A 1WN1A 2Q93A 3MR1A 3PKEA 2GTXA 4U6ZA 1C24A 3I7MA 1C27A 4ZNGA 3PKBA 2OAZA 3MX6A 1KQ9A 2BHBA 2GZ5A 2IW2A 3L24A 4RZZA 5D6EA 1R5GA 1XGSA 2EA4A 1A16A 4FLKA 2V6CA 3PEBA 4IPAA 4U69A 4S2TP 3S6BA 5JI6A 4RGZ1 1C22A 4MATA 1WBQA 1XGNA 3IU7A 3BITA 1B6AA 1C21A 1WLRA 4B28A 2Q94A 4FLLA 3IU8A 4FUKA 2V3YA 5CNXA 2ADUA 2NQ6A 2OKNA 1QZYA 2G6PA 2GU6A 3TAVA 2V3XA 3CB5A 2GG8A 4ZWPA 4U71A 2BWYA 5FCHA 5E5BA 1YVMA 1CHMA 1N51A 3PKCA 2NQ7A 4FO7A 3OOOA 4U6WA 4R60A 1W2MA 5D6FA 2P99A 2Q92A 1R58A 4IKUA 1Y1NA 5FCFA 1WL6A 3BIQA 1XGMA 3QOCA 4FO8A 1BOAA 1XGOA 3CB6A 3IU9A 3IG4A 4IKSA 4PNCA 4S01A 3CTZA 2BWXA 1KQ0A 1BN5A 3IL0A 2DFIA 2GG5A 4PV4A 4IDYA 1KP0A 4U1BA 1O0XA 2Q96A 3RORA 4RZYA 1JAWA 1PV9A 2HOWA 2BN7A 1C23A 2Q95A 4U6CA 3TB5A 4U70A 5JFRA 1QXWA 2ZSGA 2BWUA 4FLIA 2GG2A 4ZWUA 5CDEA 3OVKA 3PN9A 1MATA 2GU5A 3O5VA 1B59A 2GG3A 2BWSA 2BH3A 2EA2A 4HXXA 4IKTA 4A6WA 4IU6A 2V3ZA 3FM3A 4IECA 3L7GA 5CLSA 1WY2A 4IKRA 4KM3A 4U6JA 2GGBA 1QXZA
chains in the Genus database with same CATH topology
4FKCA 2BB7A 2EVMA 3PKDA 4A6VA 3Q6DA 2EVOA 2GA2A 2GG7A 3FMQA 1XNZA 1YJ3A 4OOKA 5CDLA 3D27A 5CIKA 3FMRA 5E2CA 2GG9A 4S2RP 2BWVA 4U75A 2BHDA 1WL9A 3BIPA 2BHCA 3MATA 4S00A 1WKMA 2GG0A 4U73A 4QR8A 2B3KA 2BHAA 1YW9A 2EVCA 4JUQA 4ZWOA 5CDVA 2MATA 1R5HA 1YW7A 1YW8A 1M35A 2BWWA 2GGCA 2BWTA 4IF7A 4U6EA 2GU7A 1QXYA 2Q8KA 4Z7MA 3RVAA 2P98A 3PKAA 5CE6A 4EGEA 5JHUA 2B3HA 1W7VA 2B3LA 4U76A 2P9AA 4FLJA 2GU4A 1WN1A 2Q93A 3MR1A 3PKEA 2GTXA 4U6ZA 1C24A 3I7MA 1C27A 4ZNGA 3PKBA 2OAZA 3MX6A 1KQ9A 2BHBA 2GZ5A 2IW2A 3L24A 4RZZA 5D6EA 1R5GA 1XGSA 2EA4A 1A16A 4FLKA 2V6CA 3PEBA 4IPAA 4U69A 4S2TP 3S6BA 5JI6A 4RGZ1 1C22A 4MATA 1WBQA 1XGNA 3IU7A 3BITA 1B6AA 1C21A 1WLRA 4B28A 2Q94A 4FLLA 3IU8A 4FUKA 2V3YA 5CNXA 2ADUA 2NQ6A 2OKNA 1QZYA 2G6PA 2GU6A 3TAVA 2V3XA 3CB5A 2GG8A 4ZWPA 4U71A 2BWYA 5FCHA 5E5BA 1YVMA 1CHMA 1N51A 3PKCA 2NQ7A 4FO7A 3OOOA 4U6WA 4R60A 1W2MA 5D6FA 2P99A 2Q92A 1R58A 4IKUA 1Y1NA 5FCFA 1WL6A 3BIQA 1XGMA 3QOCA 4FO8A 1BOAA 1XGOA 3CB6A 3IU9A 3IG4A 4IKSA 4PNCA 4S01A 3CTZA 2BWXA 1KQ0A 1BN5A 3IL0A 2DFIA 2GG5A 4PV4A 4IDYA 1KP0A 4U1BA 1O0XA 2Q96A 3RORA 4RZYA 1JAWA 1PV9A 2HOWA 2BN7A 1C23A 2Q95A 4U6CA 3TB5A 4U70A 5JFRA 1QXWA 2ZSGA 2BWUA 4FLIA 2GG2A 4ZWUA 5CDEA 3OVKA 3PN9A 1MATA 2GU5A 3O5VA 1B59A 2GG3A 2BWSA 2BH3A 2EA2A 4HXXA 4IKTA 4A6WA 4IU6A 2V3ZA 3FM3A 4IECA 3L7GA 5CLSA 1WY2A 4IKRA 4KM3A 4U6JA 2GGBA 1QXZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FKC A;  2BB7 A;  2EVM A;  3PKD A;  4A6V A;  3Q6D A;  2EVO A;  2GA2 A;  2GG7 A;  3FMQ A;  1XNZ A;  1YJ3 A;  4OOK A;  5CDL A;  3D27 A;  5CIK A;  3FMR A;  5E2C A;  2GG9 A;  4S2R P;  2BWV A;  4U75 A;  2BHD A;  1WL9 A;  3BIP A;  2BHC A;  3MAT A;  4S00 A;  1WKM A;  2GG0 A;  4U73 A;  4QR8 A;  2B3K A;  2BHA A;  1YW9 A;  2EVC A;  4JUQ A;  4ZWO A;  5CDV A;  2MAT A;  1R5H A;  1YW7 A;  1YW8 A;  1M35 A;  2BWW A;  2GGC A;  2BWT A;  4IF7 A;  4U6E A;  2GU7 A;  1QXY A;  2Q8K A;  4Z7M A;  3RVA A;  2P98 A;  3PKA A;  5CE6 A;  4EGE A;  5JHU A;  2B3H A;  1W7V A;  2B3L A;  4U76 A;  2P9A A;  4FLJ A;  2GU4 A;  1WN1 A;  2Q93 A;  3MR1 A;  3PKE A;  2GTX A;  4U6Z A;  1C24 A;  3I7M A;  1C27 A;  4ZNG A;  3PKB A;  2OAZ A;  3MX6 A;  1KQ9 A;  2BHB A;  2GZ5 A;  2IW2 A;  3L24 A;  4RZZ A;  5D6E A;  1R5G A;  1XGS A;  2EA4 A;  1A16 A;  4FLK A;  2V6C A;  3PEB A;  4IPA A;  4U69 A;  4S2T P;  3S6B A;  5JI6 A;  4RGZ 1;  1C22 A;  4MAT A;  1WBQ A;  1XGN A;  3IU7 A;  3BIT A;  1B6A A;  1C21 A;  1WLR A;  4B28 A;  2Q94 A;  4FLL A;  3IU8 A;  4FUK A;  2V3Y A;  5CNX A;  2ADU A;  2NQ6 A;  2OKN A;  1QZY A;  2G6P A;  2GU6 A;  3TAV A;  2V3X A;  3CB5 A;  2GG8 A;  4ZWP A;  4U71 A;  2BWY A;  5FCH A;  5E5B A;  1YVM A;  1CHM A;  1N51 A;  3PKC A;  2NQ7 A;  4FO7 A;  3OOO A;  4U6W A;  4R60 A;  1W2M A;  5D6F A;  2P99 A;  2Q92 A;  1R58 A;  4IKU A;  1Y1N A;  5FCF A;  1WL6 A;  3BIQ A;  1XGM A;  3QOC A;  4FO8 A;  1BOA A;  1XGO A;  3CB6 A;  3IU9 A;  3IG4 A;  4IKS A;  4PNC A;  4S01 A;  3CTZ A;  2BWX A;  1KQ0 A;  1BN5 A;  3IL0 A;  2DFI A;  2GG5 A;  4PV4 A;  4IDY A;  1KP0 A;  4U1B A;  1O0X A;  2Q96 A;  3ROR A;  4RZY A;  1JAW A;  1PV9 A;  2HOW A;  2BN7 A;  1C23 A;  2Q95 A;  4U6C A;  3TB5 A;  4U70 A;  5JFR A;  1QXW A;  2ZSG A;  2BWU A;  4FLI A;  2GG2 A;  4ZWU A;  5CDE A;  3OVK A;  3PN9 A;  1MAT A;  2GU5 A;  3O5V A;  1B59 A;  2GG3 A;  2BWS A;  2BH3 A;  2EA2 A;  4HXX A;  4IKT A;  4A6W A;  4IU6 A;  2V3Z A;  3FM3 A;  4IEC A;  3L7G A;  5CLS A;  1WY2 A;  4IKR A;  4KM3 A;  4U6J A;  2GGB A;  1QXZ A; 
#chains in the Genus database with same CATH topology
 4FKC A;  2BB7 A;  2EVM A;  3PKD A;  4A6V A;  3Q6D A;  2EVO A;  2GA2 A;  2GG7 A;  3FMQ A;  1XNZ A;  1YJ3 A;  4OOK A;  5CDL A;  3D27 A;  5CIK A;  3FMR A;  5E2C A;  2GG9 A;  4S2R P;  2BWV A;  4U75 A;  2BHD A;  1WL9 A;  3BIP A;  2BHC A;  3MAT A;  4S00 A;  1WKM A;  2GG0 A;  4U73 A;  4QR8 A;  2B3K A;  2BHA A;  1YW9 A;  2EVC A;  4JUQ A;  4ZWO A;  5CDV A;  2MAT A;  1R5H A;  1YW7 A;  1YW8 A;  1M35 A;  2BWW A;  2GGC A;  2BWT A;  4IF7 A;  4U6E A;  2GU7 A;  1QXY A;  2Q8K A;  4Z7M A;  3RVA A;  2P98 A;  3PKA A;  5CE6 A;  4EGE A;  5JHU A;  2B3H A;  1W7V A;  2B3L A;  4U76 A;  2P9A A;  4FLJ A;  2GU4 A;  1WN1 A;  2Q93 A;  3MR1 A;  3PKE A;  2GTX A;  4U6Z A;  1C24 A;  3I7M A;  1C27 A;  4ZNG A;  3PKB A;  2OAZ A;  3MX6 A;  1KQ9 A;  2BHB A;  2GZ5 A;  2IW2 A;  3L24 A;  4RZZ A;  5D6E A;  1R5G A;  1XGS A;  2EA4 A;  1A16 A;  4FLK A;  2V6C A;  3PEB A;  4IPA A;  4U69 A;  4S2T P;  3S6B A;  5JI6 A;  4RGZ 1;  1C22 A;  4MAT A;  1WBQ A;  1XGN A;  3IU7 A;  3BIT A;  1B6A A;  1C21 A;  1WLR A;  4B28 A;  2Q94 A;  4FLL A;  3IU8 A;  4FUK A;  2V3Y A;  5CNX A;  2ADU A;  2NQ6 A;  2OKN A;  1QZY A;  2G6P A;  2GU6 A;  3TAV A;  2V3X A;  3CB5 A;  2GG8 A;  4ZWP A;  4U71 A;  2BWY A;  5FCH A;  5E5B A;  1YVM A;  1CHM A;  1N51 A;  3PKC A;  2NQ7 A;  4FO7 A;  3OOO A;  4U6W A;  4R60 A;  1W2M A;  5D6F A;  2P99 A;  2Q92 A;  1R58 A;  4IKU A;  1Y1N A;  5FCF A;  1WL6 A;  3BIQ A;  1XGM A;  3QOC A;  4FO8 A;  1BOA A;  1XGO A;  3CB6 A;  3IU9 A;  3IG4 A;  4IKS A;  4PNC A;  4S01 A;  3CTZ A;  2BWX A;  1KQ0 A;  1BN5 A;  3IL0 A;  2DFI A;  2GG5 A;  4PV4 A;  4IDY A;  1KP0 A;  4U1B A;  1O0X A;  2Q96 A;  3ROR A;  4RZY A;  1JAW A;  1PV9 A;  2HOW A;  2BN7 A;  1C23 A;  2Q95 A;  4U6C A;  3TB5 A;  4U70 A;  5JFR A;  1QXW A;  2ZSG A;  2BWU A;  4FLI A;  2GG2 A;  4ZWU A;  5CDE A;  3OVK A;  3PN9 A;  1MAT A;  2GU5 A;  3O5V A;  1B59 A;  2GG3 A;  2BWS A;  2BH3 A;  2EA2 A;  4HXX A;  4IKT A;  4A6W A;  4IU6 A;  2V3Z A;  3FM3 A;  4IEC A;  3L7G A;  5CLS A;  1WY2 A;  4IKR A;  4KM3 A;  4U6J A;  2GGB A;  1QXZ A; 
#chains in the Genus database with same CATH homology
 4FKC A;  2BB7 A;  2EVM A;  3PKD A;  4A6V A;  3Q6D A;  2EVO A;  2GA2 A;  2GG7 A;  3FMQ A;  1XNZ A;  1YJ3 A;  4OOK A;  5CDL A;  3D27 A;  5CIK A;  3FMR A;  5E2C A;  2GG9 A;  4S2R P;  2BWV A;  4U75 A;  2BHD A;  1WL9 A;  3BIP A;  2BHC A;  3MAT A;  4S00 A;  1WKM A;  2GG0 A;  4U73 A;  4QR8 A;  2B3K A;  2BHA A;  1YW9 A;  2EVC A;  4JUQ A;  4ZWO A;  5CDV A;  2MAT A;  1R5H A;  1YW7 A;  1YW8 A;  1M35 A;  2BWW A;  2GGC A;  2BWT A;  4IF7 A;  4U6E A;  2GU7 A;  1QXY A;  2Q8K A;  4Z7M A;  3RVA A;  2P98 A;  3PKA A;  5CE6 A;  4EGE A;  5JHU A;  2B3H A;  1W7V A;  2B3L A;  4U76 A;  2P9A A;  4FLJ A;  2GU4 A;  1WN1 A;  2Q93 A;  3MR1 A;  3PKE A;  2GTX A;  4U6Z A;  1C24 A;  3I7M A;  1C27 A;  4ZNG A;  3PKB A;  2OAZ A;  3MX6 A;  1KQ9 A;  2BHB A;  2GZ5 A;  2IW2 A;  3L24 A;  4RZZ A;  5D6E A;  1R5G A;  1XGS A;  2EA4 A;  1A16 A;  4FLK A;  2V6C A;  3PEB A;  4IPA A;  4U69 A;  4S2T P;  3S6B A;  5JI6 A;  4RGZ 1;  1C22 A;  4MAT A;  1WBQ A;  1XGN A;  3IU7 A;  3BIT A;  1B6A A;  1C21 A;  1WLR A;  4B28 A;  2Q94 A;  4FLL A;  3IU8 A;  4FUK A;  2V3Y A;  5CNX A;  2ADU A;  2NQ6 A;  2OKN A;  1QZY A;  2G6P A;  2GU6 A;  3TAV A;  2V3X A;  3CB5 A;  2GG8 A;  4ZWP A;  4U71 A;  2BWY A;  5FCH A;  5E5B A;  1YVM A;  1CHM A;  1N51 A;  3PKC A;  2NQ7 A;  4FO7 A;  3OOO A;  4U6W A;  4R60 A;  1W2M A;  5D6F A;  2P99 A;  2Q92 A;  1R58 A;  4IKU A;  1Y1N A;  5FCF A;  1WL6 A;  3BIQ A;  1XGM A;  3QOC A;  4FO8 A;  1BOA A;  1XGO A;  3CB6 A;  3IU9 A;  3IG4 A;  4IKS A;  4PNC A;  4S01 A;  3CTZ A;  2BWX A;  1KQ0 A;  1BN5 A;  3IL0 A;  2DFI A;  2GG5 A;  4PV4 A;  4IDY A;  1KP0 A;  4U1B A;  1O0X A;  2Q96 A;  3ROR A;  4RZY A;  1JAW A;  1PV9 A;  2HOW A;  2BN7 A;  1C23 A;  2Q95 A;  4U6C A;  3TB5 A;  4U70 A;  5JFR A;  1QXW A;  2ZSG A;  2BWU A;  4FLI A;  2GG2 A;  4ZWU A;  5CDE A;  3OVK A;  3PN9 A;  1MAT A;  2GU5 A;  3O5V A;  1B59 A;  2GG3 A;  2BWS A;  2BH3 A;  2EA2 A;  4HXX A;  4IKT A;  4A6W A;  4IU6 A;  2V3Z A;  3FM3 A;  4IEC A;  3L7G A;  5CLS A;  1WY2 A;  4IKR A;  4KM3 A;  4U6J A;  2GGB A;  1QXZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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