3L24A

Crystal structure of the nerve agent degrading organophosphate anhydrolase/prolidase in complex with inhibitors
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
440
structure length
425
Chain Sequence
MNKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVPDEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMALRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELRLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
pubmed doi rcsb
molecule keywords Xaa-Pro dipeptidase
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 148
structure length 425
sequence length 440
chains with identical sequence B, C
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2009-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 3l24A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3l24A02
2BWYA 3BITA 5D6FA 4U6EA 1KP0A 3IL0A 1WY2A 1WL9A 1XGNA 2B3HA 3PKAA 4S01A 1C21A 1KQ9A 2Q94A 1PV9A 2BHDA 2BH3A 3L7GA 2Q93A 2Q96A 5CDVA 2NQ6A 2EVCA 4RZYA 5E5BA 1R5HA 2EA2A 2V6CA 4ZNGA 3BIPA 4OOKA 4U70A 2ADUA 4ZWOA 3CB5A 4RZZA 4HXXA 2BWUA 1JAWA 2V3ZA 3PKBA 2V3XA 3RVAA 2BWVA 1C24A 3IU8A 4S2RP 3TB5A 2GU4A 2BWWA 5CDLA 4QR8A 1XGSA 5CE6A 4FO7A 1C23A 5CNXA 5FCHA 5JFRA 4IPAA 1MATA 1QXWA 2NQ7A 3IU7A 2GG8A 3QOCA 4IKSA 4A6VA 1A16A 3FMRA 3CB6A 4ZWPA 3IG4A 5JI6A 3L24A 1YW8A 2BHAA 3PN9A 2OAZA 2BHCA 3FMQA 4U1BA 4FLLA 3CTZA 2Q92A 1CHMA 2IW2A 1O0XA 5CDEA 2BN7A 1WN1A 1YW9A 2GA2A 2Q95A 4U73A 2V3YA 3PKDA 2BB7A 4IDYA 3MX6A 2EVMA 3TAVA 3RORA 2GU7A 3D27A 5FCFA 4U75A 5CLSA 4U71A 4U76A 2GTXA 1C22A 3MATA 1BOAA 1QZYA 2EVOA 4U6ZA 4B28A 2MATA 2GG9A 4U6JA 5CIKA 4PV4A 2ZSGA 1W2MA 1WLRA 1N51A 1W7VA 4FO8A 2B3LA 2GGCA 2GU5A 4S00A 4IECA 4R60A 4IKTA 2EA4A 2BWTA 1YVMA 1WKMA 3PKEA 2GG2A 4MATA 3OVKA 2GG7A 4A6WA 4EGEA 3BIQA 3PEBA 4JUQA 2P98A 1QXYA 4FUKA 3OOOA 2GG0A 1XGOA 3MR1A 4FLKA 3S6BA 4U69A 1R5GA 3PKCA 3Q6DA 1B59A 2DFIA 1Y1NA 4FLIA 4IF7A 4S2TP 4RGZ1 1WBQA 2GG3A 1QXZA 4IU6A 2P9AA 3IU9A 5E2CA 2GU6A 2P99A 4U6WA 4Z7MA 2GG5A 1YJ3A 4PNCA 2Q8KA 3I7MA 4IKUA 2BWXA 1M35A 1XNZA 2GGBA 5JHUA 4U6CA 1BN5A 2G6PA 1XGMA 1B6AA 4FKCA 1R58A 5D6EA 3O5VA 2OKNA 2GZ5A 4FLJA 1YW7A 1WL6A 1C27A 1KQ0A 4KM3A 4ZWUA 3FM3A 2BWSA 2B3KA 4IKRA 2BHBA 2HOWA
chains in the Genus database with same CATH superfamily
2BWYA 3BITA 5D6FA 4U6EA 1KP0A 3IL0A 1WY2A 1WL9A 1XGNA 2B3HA 3PKAA 4S01A 1C21A 1KQ9A 2Q94A 1PV9A 2BHDA 2BH3A 3L7GA 2Q93A 2Q96A 5CDVA 2NQ6A 2EVCA 4RZYA 5E5BA 1R5HA 2EA2A 2V6CA 4ZNGA 3BIPA 4OOKA 4U70A 2ADUA 4ZWOA 3CB5A 4RZZA 4HXXA 2BWUA 1JAWA 2V3ZA 3PKBA 2V3XA 3RVAA 2BWVA 1C24A 3IU8A 4S2RP 3TB5A 2GU4A 2BWWA 5CDLA 4QR8A 1XGSA 5CE6A 4FO7A 1C23A 5CNXA 5FCHA 5JFRA 4IPAA 1MATA 1QXWA 2NQ7A 3IU7A 2GG8A 3QOCA 4IKSA 4A6VA 1A16A 3FMRA 3CB6A 4ZWPA 3IG4A 5JI6A 3L24A 1YW8A 2BHAA 3PN9A 2OAZA 2BHCA 3FMQA 4U1BA 4FLLA 3CTZA 2Q92A 1CHMA 2IW2A 1O0XA 5CDEA 2BN7A 1WN1A 1YW9A 2GA2A 2Q95A 4U73A 2V3YA 3PKDA 2BB7A 4IDYA 3MX6A 2EVMA 3TAVA 3RORA 2GU7A 3D27A 5FCFA 4U75A 5CLSA 4U71A 4U76A 2GTXA 1C22A 3MATA 1BOAA 1QZYA 2EVOA 4U6ZA 4B28A 2MATA 2GG9A 4U6JA 5CIKA 4PV4A 2ZSGA 1W2MA 1WLRA 1N51A 1W7VA 4FO8A 2B3LA 2GGCA 2GU5A 4S00A 4IECA 4R60A 4IKTA 2EA4A 2BWTA 1YVMA 1WKMA 3PKEA 2GG2A 4MATA 3OVKA 2GG7A 4A6WA 4EGEA 3BIQA 3PEBA 4JUQA 2P98A 1QXYA 4FUKA 3OOOA 2GG0A 1XGOA 3MR1A 4FLKA 3S6BA 4U69A 1R5GA 3PKCA 3Q6DA 1B59A 2DFIA 1Y1NA 4FLIA 4IF7A 4S2TP 4RGZ1 1WBQA 2GG3A 1QXZA 4IU6A 2P9AA 3IU9A 5E2CA 2GU6A 2P99A 4U6WA 4Z7MA 2GG5A 1YJ3A 4PNCA 2Q8KA 3I7MA 4IKUA 2BWXA 1M35A 1XNZA 2GGBA 5JHUA 4U6CA 1BN5A 2G6PA 1XGMA 1B6AA 4FKCA 1R58A 5D6EA 3O5VA 2OKNA 2GZ5A 4FLJA 1YW7A 1WL6A 1C27A 1KQ0A 4KM3A 4ZWUA 3FM3A 2BWSA 2B3KA 4IKRA 2BHBA 2HOWA
chains in the Genus database with same CATH topology
2BWYA 3BITA 5D6FA 4U6EA 1KP0A 3IL0A 1WY2A 1WL9A 1XGNA 2B3HA 3PKAA 4S01A 1C21A 1KQ9A 2Q94A 1PV9A 2BHDA 2BH3A 3L7GA 2Q93A 2Q96A 5CDVA 2NQ6A 2EVCA 4RZYA 5E5BA 1R5HA 2EA2A 2V6CA 4ZNGA 3BIPA 4OOKA 4U70A 2ADUA 4ZWOA 3CB5A 4RZZA 4HXXA 2BWUA 1JAWA 2V3ZA 3PKBA 2V3XA 3RVAA 2BWVA 1C24A 3IU8A 4S2RP 3TB5A 2GU4A 2BWWA 5CDLA 4QR8A 1XGSA 5CE6A 4FO7A 1C23A 5CNXA 5FCHA 5JFRA 4IPAA 1MATA 1QXWA 2NQ7A 3IU7A 2GG8A 3QOCA 4IKSA 4A6VA 1A16A 3FMRA 3CB6A 4ZWPA 3IG4A 5JI6A 3L24A 1YW8A 2BHAA 3PN9A 2OAZA 2BHCA 3FMQA 4U1BA 4FLLA 3CTZA 2Q92A 1CHMA 2IW2A 1O0XA 5CDEA 2BN7A 1WN1A 1YW9A 2GA2A 2Q95A 4U73A 2V3YA 3PKDA 2BB7A 4IDYA 3MX6A 2EVMA 3TAVA 3RORA 2GU7A 3D27A 5FCFA 4U75A 5CLSA 4U71A 4U76A 2GTXA 1C22A 3MATA 1BOAA 1QZYA 2EVOA 4U6ZA 4B28A 2MATA 2GG9A 4U6JA 5CIKA 4PV4A 2ZSGA 1W2MA 1WLRA 1N51A 1W7VA 4FO8A 2B3LA 2GGCA 2GU5A 4S00A 4IECA 4R60A 4IKTA 2EA4A 2BWTA 1YVMA 1WKMA 3PKEA 2GG2A 4MATA 3OVKA 2GG7A 4A6WA 4EGEA 3BIQA 3PEBA 4JUQA 2P98A 1QXYA 4FUKA 3OOOA 2GG0A 1XGOA 3MR1A 4FLKA 3S6BA 4U69A 1R5GA 3PKCA 3Q6DA 1B59A 2DFIA 1Y1NA 4FLIA 4IF7A 4S2TP 4RGZ1 1WBQA 2GG3A 1QXZA 4IU6A 2P9AA 3IU9A 5E2CA 2GU6A 2P99A 4U6WA 4Z7MA 2GG5A 1YJ3A 4PNCA 2Q8KA 3I7MA 4IKUA 2BWXA 1M35A 1XNZA 2GGBA 5JHUA 4U6CA 1BN5A 2G6PA 1XGMA 1B6AA 4FKCA 1R58A 5D6EA 3O5VA 2OKNA 2GZ5A 4FLJA 1YW7A 1WL6A 1C27A 1KQ0A 4KM3A 4ZWUA 3FM3A 2BWSA 2B3KA 4IKRA 2BHBA 2HOWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BWY A;  3BIT A;  5D6F A;  4U6E A;  1KP0 A;  3IL0 A;  1WY2 A;  1WL9 A;  1XGN A;  2B3H A;  3PKA A;  4S01 A;  1C21 A;  1KQ9 A;  2Q94 A;  1PV9 A;  2BHD A;  2BH3 A;  3L7G A;  2Q93 A;  2Q96 A;  5CDV A;  2NQ6 A;  2EVC A;  4RZY A;  5E5B A;  1R5H A;  2EA2 A;  2V6C A;  4ZNG A;  3BIP A;  4OOK A;  4U70 A;  2ADU A;  4ZWO A;  3CB5 A;  4RZZ A;  4HXX A;  2BWU A;  1JAW A;  2V3Z A;  3PKB A;  2V3X A;  3RVA A;  2BWV A;  1C24 A;  3IU8 A;  4S2R P;  3TB5 A;  2GU4 A;  2BWW A;  5CDL A;  4QR8 A;  1XGS A;  5CE6 A;  4FO7 A;  1C23 A;  5CNX A;  5FCH A;  5JFR A;  4IPA A;  1MAT A;  1QXW A;  2NQ7 A;  3IU7 A;  2GG8 A;  3QOC A;  4IKS A;  4A6V A;  1A16 A;  3FMR A;  3CB6 A;  4ZWP A;  3IG4 A;  5JI6 A;  3L24 A;  1YW8 A;  2BHA A;  3PN9 A;  2OAZ A;  2BHC A;  3FMQ A;  4U1B A;  4FLL A;  3CTZ A;  2Q92 A;  1CHM A;  2IW2 A;  1O0X A;  5CDE A;  2BN7 A;  1WN1 A;  1YW9 A;  2GA2 A;  2Q95 A;  4U73 A;  2V3Y A;  3PKD A;  2BB7 A;  4IDY A;  3MX6 A;  2EVM A;  3TAV A;  3ROR A;  2GU7 A;  3D27 A;  5FCF A;  4U75 A;  5CLS A;  4U71 A;  4U76 A;  2GTX A;  1C22 A;  3MAT A;  1BOA A;  1QZY A;  2EVO A;  4U6Z A;  4B28 A;  2MAT A;  2GG9 A;  4U6J A;  5CIK A;  4PV4 A;  2ZSG A;  1W2M A;  1WLR A;  1N51 A;  1W7V A;  4FO8 A;  2B3L A;  2GGC A;  2GU5 A;  4S00 A;  4IEC A;  4R60 A;  4IKT A;  2EA4 A;  2BWT A;  1YVM A;  1WKM A;  3PKE A;  2GG2 A;  4MAT A;  3OVK A;  2GG7 A;  4A6W A;  4EGE A;  3BIQ A;  3PEB A;  4JUQ A;  2P98 A;  1QXY A;  4FUK A;  3OOO A;  2GG0 A;  1XGO A;  3MR1 A;  4FLK A;  3S6B A;  4U69 A;  1R5G A;  3PKC A;  3Q6D A;  1B59 A;  2DFI A;  1Y1N A;  4FLI A;  4IF7 A;  4S2T P;  4RGZ 1;  1WBQ A;  2GG3 A;  1QXZ A;  4IU6 A;  2P9A A;  3IU9 A;  5E2C A;  2GU6 A;  2P99 A;  4U6W A;  4Z7M A;  2GG5 A;  1YJ3 A;  4PNC A;  2Q8K A;  3I7M A;  4IKU A;  2BWX A;  1M35 A;  1XNZ A;  2GGB A;  5JHU A;  4U6C A;  1BN5 A;  2G6P A;  1XGM A;  1B6A A;  4FKC A;  1R58 A;  5D6E A;  3O5V A;  2OKN A;  2GZ5 A;  4FLJ A;  1YW7 A;  1WL6 A;  1C27 A;  1KQ0 A;  4KM3 A;  4ZWU A;  3FM3 A;  2BWS A;  2B3K A;  4IKR A;  2BHB A;  2HOW A; 
#chains in the Genus database with same CATH topology
 2BWY A;  3BIT A;  5D6F A;  4U6E A;  1KP0 A;  3IL0 A;  1WY2 A;  1WL9 A;  1XGN A;  2B3H A;  3PKA A;  4S01 A;  1C21 A;  1KQ9 A;  2Q94 A;  1PV9 A;  2BHD A;  2BH3 A;  3L7G A;  2Q93 A;  2Q96 A;  5CDV A;  2NQ6 A;  2EVC A;  4RZY A;  5E5B A;  1R5H A;  2EA2 A;  2V6C A;  4ZNG A;  3BIP A;  4OOK A;  4U70 A;  2ADU A;  4ZWO A;  3CB5 A;  4RZZ A;  4HXX A;  2BWU A;  1JAW A;  2V3Z A;  3PKB A;  2V3X A;  3RVA A;  2BWV A;  1C24 A;  3IU8 A;  4S2R P;  3TB5 A;  2GU4 A;  2BWW A;  5CDL A;  4QR8 A;  1XGS A;  5CE6 A;  4FO7 A;  1C23 A;  5CNX A;  5FCH A;  5JFR A;  4IPA A;  1MAT A;  1QXW A;  2NQ7 A;  3IU7 A;  2GG8 A;  3QOC A;  4IKS A;  4A6V A;  1A16 A;  3FMR A;  3CB6 A;  4ZWP A;  3IG4 A;  5JI6 A;  3L24 A;  1YW8 A;  2BHA A;  3PN9 A;  2OAZ A;  2BHC A;  3FMQ A;  4U1B A;  4FLL A;  3CTZ A;  2Q92 A;  1CHM A;  2IW2 A;  1O0X A;  5CDE A;  2BN7 A;  1WN1 A;  1YW9 A;  2GA2 A;  2Q95 A;  4U73 A;  2V3Y A;  3PKD A;  2BB7 A;  4IDY A;  3MX6 A;  2EVM A;  3TAV A;  3ROR A;  2GU7 A;  3D27 A;  5FCF A;  4U75 A;  5CLS A;  4U71 A;  4U76 A;  2GTX A;  1C22 A;  3MAT A;  1BOA A;  1QZY A;  2EVO A;  4U6Z A;  4B28 A;  2MAT A;  2GG9 A;  4U6J A;  5CIK A;  4PV4 A;  2ZSG A;  1W2M A;  1WLR A;  1N51 A;  1W7V A;  4FO8 A;  2B3L A;  2GGC A;  2GU5 A;  4S00 A;  4IEC A;  4R60 A;  4IKT A;  2EA4 A;  2BWT A;  1YVM A;  1WKM A;  3PKE A;  2GG2 A;  4MAT A;  3OVK A;  2GG7 A;  4A6W A;  4EGE A;  3BIQ A;  3PEB A;  4JUQ A;  2P98 A;  1QXY A;  4FUK A;  3OOO A;  2GG0 A;  1XGO A;  3MR1 A;  4FLK A;  3S6B A;  4U69 A;  1R5G A;  3PKC A;  3Q6D A;  1B59 A;  2DFI A;  1Y1N A;  4FLI A;  4IF7 A;  4S2T P;  4RGZ 1;  1WBQ A;  2GG3 A;  1QXZ A;  4IU6 A;  2P9A A;  3IU9 A;  5E2C A;  2GU6 A;  2P99 A;  4U6W A;  4Z7M A;  2GG5 A;  1YJ3 A;  4PNC A;  2Q8K A;  3I7M A;  4IKU A;  2BWX A;  1M35 A;  1XNZ A;  2GGB A;  5JHU A;  4U6C A;  1BN5 A;  2G6P A;  1XGM A;  1B6A A;  4FKC A;  1R58 A;  5D6E A;  3O5V A;  2OKN A;  2GZ5 A;  4FLJ A;  1YW7 A;  1WL6 A;  1C27 A;  1KQ0 A;  4KM3 A;  4ZWU A;  3FM3 A;  2BWS A;  2B3K A;  4IKR A;  2BHB A;  2HOW A; 
#chains in the Genus database with same CATH homology
 2BWY A;  3BIT A;  5D6F A;  4U6E A;  1KP0 A;  3IL0 A;  1WY2 A;  1WL9 A;  1XGN A;  2B3H A;  3PKA A;  4S01 A;  1C21 A;  1KQ9 A;  2Q94 A;  1PV9 A;  2BHD A;  2BH3 A;  3L7G A;  2Q93 A;  2Q96 A;  5CDV A;  2NQ6 A;  2EVC A;  4RZY A;  5E5B A;  1R5H A;  2EA2 A;  2V6C A;  4ZNG A;  3BIP A;  4OOK A;  4U70 A;  2ADU A;  4ZWO A;  3CB5 A;  4RZZ A;  4HXX A;  2BWU A;  1JAW A;  2V3Z A;  3PKB A;  2V3X A;  3RVA A;  2BWV A;  1C24 A;  3IU8 A;  4S2R P;  3TB5 A;  2GU4 A;  2BWW A;  5CDL A;  4QR8 A;  1XGS A;  5CE6 A;  4FO7 A;  1C23 A;  5CNX A;  5FCH A;  5JFR A;  4IPA A;  1MAT A;  1QXW A;  2NQ7 A;  3IU7 A;  2GG8 A;  3QOC A;  4IKS A;  4A6V A;  1A16 A;  3FMR A;  3CB6 A;  4ZWP A;  3IG4 A;  5JI6 A;  3L24 A;  1YW8 A;  2BHA A;  3PN9 A;  2OAZ A;  2BHC A;  3FMQ A;  4U1B A;  4FLL A;  3CTZ A;  2Q92 A;  1CHM A;  2IW2 A;  1O0X A;  5CDE A;  2BN7 A;  1WN1 A;  1YW9 A;  2GA2 A;  2Q95 A;  4U73 A;  2V3Y A;  3PKD A;  2BB7 A;  4IDY A;  3MX6 A;  2EVM A;  3TAV A;  3ROR A;  2GU7 A;  3D27 A;  5FCF A;  4U75 A;  5CLS A;  4U71 A;  4U76 A;  2GTX A;  1C22 A;  3MAT A;  1BOA A;  1QZY A;  2EVO A;  4U6Z A;  4B28 A;  2MAT A;  2GG9 A;  4U6J A;  5CIK A;  4PV4 A;  2ZSG A;  1W2M A;  1WLR A;  1N51 A;  1W7V A;  4FO8 A;  2B3L A;  2GGC A;  2GU5 A;  4S00 A;  4IEC A;  4R60 A;  4IKT A;  2EA4 A;  2BWT A;  1YVM A;  1WKM A;  3PKE A;  2GG2 A;  4MAT A;  3OVK A;  2GG7 A;  4A6W A;  4EGE A;  3BIQ A;  3PEB A;  4JUQ A;  2P98 A;  1QXY A;  4FUK A;  3OOO A;  2GG0 A;  1XGO A;  3MR1 A;  4FLK A;  3S6B A;  4U69 A;  1R5G A;  3PKC A;  3Q6D A;  1B59 A;  2DFI A;  1Y1N A;  4FLI A;  4IF7 A;  4S2T P;  4RGZ 1;  1WBQ A;  2GG3 A;  1QXZ A;  4IU6 A;  2P9A A;  3IU9 A;  5E2C A;  2GU6 A;  2P99 A;  4U6W A;  4Z7M A;  2GG5 A;  1YJ3 A;  4PNC A;  2Q8K A;  3I7M A;  4IKU A;  2BWX A;  1M35 A;  1XNZ A;  2GGB A;  5JHU A;  4U6C A;  1BN5 A;  2G6P A;  1XGM A;  1B6A A;  4FKC A;  1R58 A;  5D6E A;  3O5V A;  2OKN A;  2GZ5 A;  4FLJ A;  1YW7 A;  1WL6 A;  1C27 A;  1KQ0 A;  4KM3 A;  4ZWU A;  3FM3 A;  2BWS A;  2B3K A;  4IKR A;  2BHB A;  2HOW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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