3L24A

Crystal structure of the nerve agent degrading organophosphate anhydrolase/prolidase in complex with inhibitors
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
440
structure length
425
Chain Sequence
MNKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVPDEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMALRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELRLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
total genus 148
structure length 425
sequence length 440
chains with identical sequence B, C
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2009-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 3l24A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3l24A02
4U69A 2GG2A 1R5HA 1R58A 1YW8A 4U6ZA 4U71A 2GG3A 2BWWA 1CHMA 4MATA 4FLLA 2Q93A 3RVAA 4U76A 4HXXA 3RORA 1Y1NA 4KM3A 2GU7A 4FKCA 3MATA 3MX6A 4ZWUA 1YVMA 4S00A 1O0XA 4IECA 2GU6A 4RGZ1 4IDYA 4IKTA 1WBQA 2OKNA 1R5GA 5CDLA 1XGSA 5JHUA 2BWVA 5CIKA 1YW9A 4FLIA 1B6AA 5CDVA 3PKEA 3PEBA 2ZSGA 2GGBA 2B3HA 5JFRA 3FMQA 3D27A 3IG4A 2P98A 1W2MA 5CNXA 4EGEA 1PV9A 1BN5A 2Q95A 3PN9A 2OAZA 2BHDA 1M35A 4FO7A 1YW7A 4PNCA 1WL6A 5JI6A 5D6FA 2Q94A 3BITA 1XGOA 2GG0A 2IW2A 4U6EA 3IL0A 2GGCA 2ADUA 2BHCA 1JAWA 1XNZA 4FLKA 4U6WA 4FO8A 3CB6A 4B28A 4IKUA 4ZNGA 3TB5A 1C24A 1WN1A 1QXWA 2GG5A 2P99A 1W7VA 1C22A 2GG7A 2BWXA 4PV4A 2BWYA 1YJ3A 2B3LA 4Z7MA 3MR1A 2V6CA 4A6WA 2NQ6A 2P9AA 3IU8A 2V3XA 4IKSA 1MATA 1N51A 1C23A 2BHBA 4QR8A 4RZYA 2GU4A 2V3ZA 5E2CA 4OOKA 4U73A 2EVOA 1QXZA 2DFIA 3PKDA 5CE6A 4ZWPA 1BOAA 4IF7A 2BB7A 1XGNA 3L7GA 1C27A 2V3YA 1A16A 2GZ5A 4U75A 2Q8KA 1QXYA 2HOWA 3TAVA 3BIPA 2B3KA 2MATA 4U6CA 2G6PA 3I7MA 4U70A 3FMRA 3L24A 2GA2A 5D6EA 2GG8A 2BHAA 2EVCA 4IU6A 4FLJA 2GG9A 2Q92A 3OVKA 5CDEA 1KQ0A 2NQ7A 3PKAA 3OOOA 3BIQA 4JUQA 3Q6DA 1XGMA 2BWUA 2GTXA 4S01A 4U6JA 2Q96A 1KQ9A 3PKCA 2BWTA 5CLSA 2BN7A 1WY2A 1WLRA 4RZZA 3IU9A 4IKRA 5FCFA 1WL9A 2GU5A 5FCHA 1C21A 4S2RP 4R60A 3IU7A 2BH3A 3PKBA 3CTZA 4S2TP 4ZWOA 2EA2A 3FM3A 3S6BA 2BWSA 3CB5A 3QOCA 4FUKA 1QZYA 2EA4A 2EVMA 1KP0A 4A6VA 4IPAA 1WKMA 1B59A 4U1BA 3O5VA 5E5BA
chains in the Genus database with same CATH superfamily
4U69A 2GG2A 1R5HA 1R58A 1YW8A 4U6ZA 4U71A 2GG3A 2BWWA 1CHMA 4MATA 4FLLA 2Q93A 3RVAA 4U76A 4HXXA 3RORA 1Y1NA 4KM3A 2GU7A 4FKCA 3MATA 3MX6A 4ZWUA 1YVMA 4S00A 1O0XA 4IECA 2GU6A 4RGZ1 4IDYA 4IKTA 1WBQA 2OKNA 1R5GA 5CDLA 1XGSA 5JHUA 2BWVA 5CIKA 1YW9A 4FLIA 1B6AA 5CDVA 3PKEA 3PEBA 2ZSGA 2GGBA 2B3HA 5JFRA 3FMQA 3D27A 3IG4A 2P98A 1W2MA 5CNXA 4EGEA 1PV9A 1BN5A 2Q95A 3PN9A 2OAZA 2BHDA 1M35A 4FO7A 1YW7A 4PNCA 1WL6A 5JI6A 5D6FA 2Q94A 3BITA 1XGOA 2GG0A 2IW2A 4U6EA 3IL0A 2GGCA 2ADUA 2BHCA 1JAWA 1XNZA 4FLKA 4U6WA 4FO8A 3CB6A 4B28A 4IKUA 4ZNGA 3TB5A 1C24A 1WN1A 1QXWA 2GG5A 2P99A 1W7VA 1C22A 2GG7A 2BWXA 4PV4A 2BWYA 1YJ3A 2B3LA 4Z7MA 3MR1A 2V6CA 4A6WA 2NQ6A 2P9AA 3IU8A 2V3XA 4IKSA 1MATA 1N51A 1C23A 2BHBA 4QR8A 4RZYA 2GU4A 2V3ZA 5E2CA 4OOKA 4U73A 2EVOA 1QXZA 2DFIA 3PKDA 5CE6A 4ZWPA 1BOAA 4IF7A 2BB7A 1XGNA 3L7GA 1C27A 2V3YA 1A16A 2GZ5A 4U75A 2Q8KA 1QXYA 2HOWA 3TAVA 3BIPA 2B3KA 2MATA 4U6CA 2G6PA 3I7MA 4U70A 3FMRA 3L24A 2GA2A 5D6EA 2GG8A 2BHAA 2EVCA 4IU6A 4FLJA 2GG9A 2Q92A 3OVKA 5CDEA 1KQ0A 2NQ7A 3PKAA 3OOOA 3BIQA 4JUQA 3Q6DA 1XGMA 2BWUA 2GTXA 4S01A 4U6JA 2Q96A 1KQ9A 3PKCA 2BWTA 5CLSA 2BN7A 1WY2A 1WLRA 4RZZA 3IU9A 4IKRA 5FCFA 1WL9A 2GU5A 5FCHA 1C21A 4S2RP 4R60A 3IU7A 2BH3A 3PKBA 3CTZA 4S2TP 4ZWOA 2EA2A 3FM3A 3S6BA 2BWSA 3CB5A 3QOCA 4FUKA 1QZYA 2EA4A 2EVMA 1KP0A 4A6VA 4IPAA 1WKMA 1B59A 4U1BA 3O5VA 5E5BA
chains in the Genus database with same CATH topology
4U69A 2GG2A 1R5HA 1R58A 1YW8A 4U6ZA 4U71A 2GG3A 2BWWA 1CHMA 4MATA 4FLLA 2Q93A 3RVAA 4U76A 4HXXA 3RORA 1Y1NA 4KM3A 2GU7A 4FKCA 3MATA 3MX6A 4ZWUA 1YVMA 4S00A 1O0XA 4IECA 2GU6A 4RGZ1 4IDYA 4IKTA 1WBQA 2OKNA 1R5GA 5CDLA 1XGSA 5JHUA 2BWVA 5CIKA 1YW9A 4FLIA 1B6AA 5CDVA 3PKEA 3PEBA 2ZSGA 2GGBA 2B3HA 5JFRA 3FMQA 3D27A 3IG4A 2P98A 1W2MA 5CNXA 4EGEA 1PV9A 1BN5A 2Q95A 3PN9A 2OAZA 2BHDA 1M35A 4FO7A 1YW7A 4PNCA 1WL6A 5JI6A 5D6FA 2Q94A 3BITA 1XGOA 2GG0A 2IW2A 4U6EA 3IL0A 2GGCA 2ADUA 2BHCA 1JAWA 1XNZA 4FLKA 4U6WA 4FO8A 3CB6A 4B28A 4IKUA 4ZNGA 3TB5A 1C24A 1WN1A 1QXWA 2GG5A 2P99A 1W7VA 1C22A 2GG7A 2BWXA 4PV4A 2BWYA 1YJ3A 2B3LA 4Z7MA 3MR1A 2V6CA 4A6WA 2NQ6A 2P9AA 3IU8A 2V3XA 4IKSA 1MATA 1N51A 1C23A 2BHBA 4QR8A 4RZYA 2GU4A 2V3ZA 5E2CA 4OOKA 4U73A 2EVOA 1QXZA 2DFIA 3PKDA 5CE6A 4ZWPA 1BOAA 4IF7A 2BB7A 1XGNA 3L7GA 1C27A 2V3YA 1A16A 2GZ5A 4U75A 2Q8KA 1QXYA 2HOWA 3TAVA 3BIPA 2B3KA 2MATA 4U6CA 2G6PA 3I7MA 4U70A 3FMRA 3L24A 2GA2A 5D6EA 2GG8A 2BHAA 2EVCA 4IU6A 4FLJA 2GG9A 2Q92A 3OVKA 5CDEA 1KQ0A 2NQ7A 3PKAA 3OOOA 3BIQA 4JUQA 3Q6DA 1XGMA 2BWUA 2GTXA 4S01A 4U6JA 2Q96A 1KQ9A 3PKCA 2BWTA 5CLSA 2BN7A 1WY2A 1WLRA 4RZZA 3IU9A 4IKRA 5FCFA 1WL9A 2GU5A 5FCHA 1C21A 4S2RP 4R60A 3IU7A 2BH3A 3PKBA 3CTZA 4S2TP 4ZWOA 2EA2A 3FM3A 3S6BA 2BWSA 3CB5A 3QOCA 4FUKA 1QZYA 2EA4A 2EVMA 1KP0A 4A6VA 4IPAA 1WKMA 1B59A 4U1BA 3O5VA 5E5BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U69 A;  2GG2 A;  1R5H A;  1R58 A;  1YW8 A;  4U6Z A;  4U71 A;  2GG3 A;  2BWW A;  1CHM A;  4MAT A;  4FLL A;  2Q93 A;  3RVA A;  4U76 A;  4HXX A;  3ROR A;  1Y1N A;  4KM3 A;  2GU7 A;  4FKC A;  3MAT A;  3MX6 A;  4ZWU A;  1YVM A;  4S00 A;  1O0X A;  4IEC A;  2GU6 A;  4RGZ 1;  4IDY A;  4IKT A;  1WBQ A;  2OKN A;  1R5G A;  5CDL A;  1XGS A;  5JHU A;  2BWV A;  5CIK A;  1YW9 A;  4FLI A;  1B6A A;  5CDV A;  3PKE A;  3PEB A;  2ZSG A;  2GGB A;  2B3H A;  5JFR A;  3FMQ A;  3D27 A;  3IG4 A;  2P98 A;  1W2M A;  5CNX A;  4EGE A;  1PV9 A;  1BN5 A;  2Q95 A;  3PN9 A;  2OAZ A;  2BHD A;  1M35 A;  4FO7 A;  1YW7 A;  4PNC A;  1WL6 A;  5JI6 A;  5D6F A;  2Q94 A;  3BIT A;  1XGO A;  2GG0 A;  2IW2 A;  4U6E A;  3IL0 A;  2GGC A;  2ADU A;  2BHC A;  1JAW A;  1XNZ A;  4FLK A;  4U6W A;  4FO8 A;  3CB6 A;  4B28 A;  4IKU A;  4ZNG A;  3TB5 A;  1C24 A;  1WN1 A;  1QXW A;  2GG5 A;  2P99 A;  1W7V A;  1C22 A;  2GG7 A;  2BWX A;  4PV4 A;  2BWY A;  1YJ3 A;  2B3L A;  4Z7M A;  3MR1 A;  2V6C A;  4A6W A;  2NQ6 A;  2P9A A;  3IU8 A;  2V3X A;  4IKS A;  1MAT A;  1N51 A;  1C23 A;  2BHB A;  4QR8 A;  4RZY A;  2GU4 A;  2V3Z A;  5E2C A;  4OOK A;  4U73 A;  2EVO A;  1QXZ A;  2DFI A;  3PKD A;  5CE6 A;  4ZWP A;  1BOA A;  4IF7 A;  2BB7 A;  1XGN A;  3L7G A;  1C27 A;  2V3Y A;  1A16 A;  2GZ5 A;  4U75 A;  2Q8K A;  1QXY A;  2HOW A;  3TAV A;  3BIP A;  2B3K A;  2MAT A;  4U6C A;  2G6P A;  3I7M A;  4U70 A;  3FMR A;  3L24 A;  2GA2 A;  5D6E A;  2GG8 A;  2BHA A;  2EVC A;  4IU6 A;  4FLJ A;  2GG9 A;  2Q92 A;  3OVK A;  5CDE A;  1KQ0 A;  2NQ7 A;  3PKA A;  3OOO A;  3BIQ A;  4JUQ A;  3Q6D A;  1XGM A;  2BWU A;  2GTX A;  4S01 A;  4U6J A;  2Q96 A;  1KQ9 A;  3PKC A;  2BWT A;  5CLS A;  2BN7 A;  1WY2 A;  1WLR A;  4RZZ A;  3IU9 A;  4IKR A;  5FCF A;  1WL9 A;  2GU5 A;  5FCH A;  1C21 A;  4S2R P;  4R60 A;  3IU7 A;  2BH3 A;  3PKB A;  3CTZ A;  4S2T P;  4ZWO A;  2EA2 A;  3FM3 A;  3S6B A;  2BWS A;  3CB5 A;  3QOC A;  4FUK A;  1QZY A;  2EA4 A;  2EVM A;  1KP0 A;  4A6V A;  4IPA A;  1WKM A;  1B59 A;  4U1B A;  3O5V A;  5E5B A; 
#chains in the Genus database with same CATH topology
 4U69 A;  2GG2 A;  1R5H A;  1R58 A;  1YW8 A;  4U6Z A;  4U71 A;  2GG3 A;  2BWW A;  1CHM A;  4MAT A;  4FLL A;  2Q93 A;  3RVA A;  4U76 A;  4HXX A;  3ROR A;  1Y1N A;  4KM3 A;  2GU7 A;  4FKC A;  3MAT A;  3MX6 A;  4ZWU A;  1YVM A;  4S00 A;  1O0X A;  4IEC A;  2GU6 A;  4RGZ 1;  4IDY A;  4IKT A;  1WBQ A;  2OKN A;  1R5G A;  5CDL A;  1XGS A;  5JHU A;  2BWV A;  5CIK A;  1YW9 A;  4FLI A;  1B6A A;  5CDV A;  3PKE A;  3PEB A;  2ZSG A;  2GGB A;  2B3H A;  5JFR A;  3FMQ A;  3D27 A;  3IG4 A;  2P98 A;  1W2M A;  5CNX A;  4EGE A;  1PV9 A;  1BN5 A;  2Q95 A;  3PN9 A;  2OAZ A;  2BHD A;  1M35 A;  4FO7 A;  1YW7 A;  4PNC A;  1WL6 A;  5JI6 A;  5D6F A;  2Q94 A;  3BIT A;  1XGO A;  2GG0 A;  2IW2 A;  4U6E A;  3IL0 A;  2GGC A;  2ADU A;  2BHC A;  1JAW A;  1XNZ A;  4FLK A;  4U6W A;  4FO8 A;  3CB6 A;  4B28 A;  4IKU A;  4ZNG A;  3TB5 A;  1C24 A;  1WN1 A;  1QXW A;  2GG5 A;  2P99 A;  1W7V A;  1C22 A;  2GG7 A;  2BWX A;  4PV4 A;  2BWY A;  1YJ3 A;  2B3L A;  4Z7M A;  3MR1 A;  2V6C A;  4A6W A;  2NQ6 A;  2P9A A;  3IU8 A;  2V3X A;  4IKS A;  1MAT A;  1N51 A;  1C23 A;  2BHB A;  4QR8 A;  4RZY A;  2GU4 A;  2V3Z A;  5E2C A;  4OOK A;  4U73 A;  2EVO A;  1QXZ A;  2DFI A;  3PKD A;  5CE6 A;  4ZWP A;  1BOA A;  4IF7 A;  2BB7 A;  1XGN A;  3L7G A;  1C27 A;  2V3Y A;  1A16 A;  2GZ5 A;  4U75 A;  2Q8K A;  1QXY A;  2HOW A;  3TAV A;  3BIP A;  2B3K A;  2MAT A;  4U6C A;  2G6P A;  3I7M A;  4U70 A;  3FMR A;  3L24 A;  2GA2 A;  5D6E A;  2GG8 A;  2BHA A;  2EVC A;  4IU6 A;  4FLJ A;  2GG9 A;  2Q92 A;  3OVK A;  5CDE A;  1KQ0 A;  2NQ7 A;  3PKA A;  3OOO A;  3BIQ A;  4JUQ A;  3Q6D A;  1XGM A;  2BWU A;  2GTX A;  4S01 A;  4U6J A;  2Q96 A;  1KQ9 A;  3PKC A;  2BWT A;  5CLS A;  2BN7 A;  1WY2 A;  1WLR A;  4RZZ A;  3IU9 A;  4IKR A;  5FCF A;  1WL9 A;  2GU5 A;  5FCH A;  1C21 A;  4S2R P;  4R60 A;  3IU7 A;  2BH3 A;  3PKB A;  3CTZ A;  4S2T P;  4ZWO A;  2EA2 A;  3FM3 A;  3S6B A;  2BWS A;  3CB5 A;  3QOC A;  4FUK A;  1QZY A;  2EA4 A;  2EVM A;  1KP0 A;  4A6V A;  4IPA A;  1WKM A;  1B59 A;  4U1B A;  3O5V A;  5E5B A; 
#chains in the Genus database with same CATH homology
 4U69 A;  2GG2 A;  1R5H A;  1R58 A;  1YW8 A;  4U6Z A;  4U71 A;  2GG3 A;  2BWW A;  1CHM A;  4MAT A;  4FLL A;  2Q93 A;  3RVA A;  4U76 A;  4HXX A;  3ROR A;  1Y1N A;  4KM3 A;  2GU7 A;  4FKC A;  3MAT A;  3MX6 A;  4ZWU A;  1YVM A;  4S00 A;  1O0X A;  4IEC A;  2GU6 A;  4RGZ 1;  4IDY A;  4IKT A;  1WBQ A;  2OKN A;  1R5G A;  5CDL A;  1XGS A;  5JHU A;  2BWV A;  5CIK A;  1YW9 A;  4FLI A;  1B6A A;  5CDV A;  3PKE A;  3PEB A;  2ZSG A;  2GGB A;  2B3H A;  5JFR A;  3FMQ A;  3D27 A;  3IG4 A;  2P98 A;  1W2M A;  5CNX A;  4EGE A;  1PV9 A;  1BN5 A;  2Q95 A;  3PN9 A;  2OAZ A;  2BHD A;  1M35 A;  4FO7 A;  1YW7 A;  4PNC A;  1WL6 A;  5JI6 A;  5D6F A;  2Q94 A;  3BIT A;  1XGO A;  2GG0 A;  2IW2 A;  4U6E A;  3IL0 A;  2GGC A;  2ADU A;  2BHC A;  1JAW A;  1XNZ A;  4FLK A;  4U6W A;  4FO8 A;  3CB6 A;  4B28 A;  4IKU A;  4ZNG A;  3TB5 A;  1C24 A;  1WN1 A;  1QXW A;  2GG5 A;  2P99 A;  1W7V A;  1C22 A;  2GG7 A;  2BWX A;  4PV4 A;  2BWY A;  1YJ3 A;  2B3L A;  4Z7M A;  3MR1 A;  2V6C A;  4A6W A;  2NQ6 A;  2P9A A;  3IU8 A;  2V3X A;  4IKS A;  1MAT A;  1N51 A;  1C23 A;  2BHB A;  4QR8 A;  4RZY A;  2GU4 A;  2V3Z A;  5E2C A;  4OOK A;  4U73 A;  2EVO A;  1QXZ A;  2DFI A;  3PKD A;  5CE6 A;  4ZWP A;  1BOA A;  4IF7 A;  2BB7 A;  1XGN A;  3L7G A;  1C27 A;  2V3Y A;  1A16 A;  2GZ5 A;  4U75 A;  2Q8K A;  1QXY A;  2HOW A;  3TAV A;  3BIP A;  2B3K A;  2MAT A;  4U6C A;  2G6P A;  3I7M A;  4U70 A;  3FMR A;  3L24 A;  2GA2 A;  5D6E A;  2GG8 A;  2BHA A;  2EVC A;  4IU6 A;  4FLJ A;  2GG9 A;  2Q92 A;  3OVK A;  5CDE A;  1KQ0 A;  2NQ7 A;  3PKA A;  3OOO A;  3BIQ A;  4JUQ A;  3Q6D A;  1XGM A;  2BWU A;  2GTX A;  4S01 A;  4U6J A;  2Q96 A;  1KQ9 A;  3PKC A;  2BWT A;  5CLS A;  2BN7 A;  1WY2 A;  1WLR A;  4RZZ A;  3IU9 A;  4IKR A;  5FCF A;  1WL9 A;  2GU5 A;  5FCH A;  1C21 A;  4S2R P;  4R60 A;  3IU7 A;  2BH3 A;  3PKB A;  3CTZ A;  4S2T P;  4ZWO A;  2EA2 A;  3FM3 A;  3S6B A;  2BWS A;  3CB5 A;  3QOC A;  4FUK A;  1QZY A;  2EA4 A;  2EVM A;  1KP0 A;  4A6V A;  4IPA A;  1WKM A;  1B59 A;  4U1B A;  3O5V A;  5E5B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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