3L24A

Crystal structure of the nerve agent degrading organophosphate anhydrolase/prolidase in complex with inhibitors
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
440
structure length
425
Chain Sequence
MNKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVPDEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMALRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELRLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Xaa-Pro dipeptidase
publication title Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 148
structure length 425
sequence length 440
chains with identical sequence B, C
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2009-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 3l24A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3l24A02
1MATA 1C23A 1XGNA 2GG7A 2P99A 4RZZA 5CDLA 2Q93A 4IECA 5CDEA 4QR8A 2GGBA 5JFRA 5CLSA 2BHBA 2GG3A 5E2CA 4FLIA 5JI6A 3IU8A 5D6FA 2P98A 2BWSA 3QOCA 4FLJA 4U71A 1QXZA 2MATA 1YW8A 4S00A 1B6AA 1N51A 1KP0A 2GG5A 1PV9A 4MATA 1WY2A 4U73A 3L7GA 3MATA 3O5VA 3Q6DA 4FUKA 2V3YA 2BWYA 2EA4A 1W2MA 2GGCA 2GTXA 2GU5A 2Q95A 4IKSA 1BN5A 4U6JA 1BOAA 2ADUA 5E5BA 2Q94A 2P9AA 4ZNGA 1XGMA 1WBQA 2EVCA 3BITA 4U6WA 2Q96A 1R58A 5D6EA 3RORA 4EGEA 3L24A 1YW9A 4JUQA 4PNCA 4U6EA 1CHMA 3PKDA 2Q92A 3MX6A 1M35A 3TAVA 3RVAA 3S6BA 2GG8A 2BWUA 1W7VA 2GU7A 4IKUA 1B59A 4S2TP 2GG9A 2IW2A 2ZSGA 4Z7MA 3IG4A 3OVKA 2EA2A 4U75A 2BH3A 2V3ZA 3PEBA 1C21A 4IF7A 1R5HA 5CE6A 2Q8KA 1WN1A 4S01A 3PKCA 5FCHA 3PKAA 1QXYA 5CDVA 2BWWA 1WLRA 1Y1NA 1A16A 1KQ0A 4OOKA 3CTZA 2GU4A 2B3HA 4U6CA 1WKMA 3TB5A 3CB6A 2OKNA 4FO8A 2GZ5A 2G6PA 2B3KA 4ZWOA 4ZWUA 1YJ3A 4A6VA 3PKEA 1XGSA 4PV4A 1WL9A 4RZYA 2NQ6A 2BWVA 2OAZA 1XGOA 2BB7A 2BWTA 5JHUA 2DFIA 4HXXA 4U69A 4FKCA 2V6CA 3MR1A 3I7MA 2BHCA 2HOWA 3BIPA 3FMRA 1XNZA 2V3XA 4IU6A 4KM3A 5FCFA 3IU7A 3OOOA 4RGZ1 3PN9A 4U76A 1C27A 2BHDA 4IDYA 4U70A 2NQ7A 5CNXA 3FMQA 4FLKA 3CB5A 2B3LA 4FO7A 2GA2A 4IKTA 1QZYA 4B28A 4A6WA 2EVMA 1O0XA 4U6ZA 3D27A 1C22A 2EVOA 2BHAA 3IL0A 2GG0A 3IU9A 4R60A 4ZWPA 1C24A 1YW7A 3BIQA 1JAWA 1R5GA 5CIKA 4IKRA 2BN7A 1QXWA 4S2RP 2BWXA 1YVMA 4IPAA 4FLLA 2GG2A 3PKBA 2GU6A 4U1BA 3FM3A 1KQ9A 1WL6A
chains in the Genus database with same CATH superfamily
1MATA 1C23A 1XGNA 2GG7A 2P99A 4RZZA 5CDLA 2Q93A 4IECA 5CDEA 4QR8A 2GGBA 5JFRA 5CLSA 2BHBA 2GG3A 5E2CA 4FLIA 5JI6A 3IU8A 5D6FA 2P98A 2BWSA 3QOCA 4FLJA 4U71A 1QXZA 2MATA 1YW8A 4S00A 1B6AA 1N51A 1KP0A 2GG5A 1PV9A 4MATA 1WY2A 4U73A 3L7GA 3MATA 3O5VA 3Q6DA 4FUKA 2V3YA 2BWYA 2EA4A 1W2MA 2GGCA 2GTXA 2GU5A 2Q95A 4IKSA 1BN5A 4U6JA 1BOAA 2ADUA 5E5BA 2Q94A 2P9AA 4ZNGA 1XGMA 1WBQA 2EVCA 3BITA 4U6WA 2Q96A 1R58A 5D6EA 3RORA 4EGEA 3L24A 1YW9A 4JUQA 4PNCA 4U6EA 1CHMA 3PKDA 2Q92A 3MX6A 1M35A 3TAVA 3RVAA 3S6BA 2GG8A 2BWUA 1W7VA 2GU7A 4IKUA 1B59A 4S2TP 2GG9A 2IW2A 2ZSGA 4Z7MA 3IG4A 3OVKA 2EA2A 4U75A 2BH3A 2V3ZA 3PEBA 1C21A 4IF7A 1R5HA 5CE6A 2Q8KA 1WN1A 4S01A 3PKCA 5FCHA 3PKAA 1QXYA 5CDVA 2BWWA 1WLRA 1Y1NA 1A16A 1KQ0A 4OOKA 3CTZA 2GU4A 2B3HA 4U6CA 1WKMA 3TB5A 3CB6A 2OKNA 4FO8A 2GZ5A 2G6PA 2B3KA 4ZWOA 4ZWUA 1YJ3A 4A6VA 3PKEA 1XGSA 4PV4A 1WL9A 4RZYA 2NQ6A 2BWVA 2OAZA 1XGOA 2BB7A 2BWTA 5JHUA 2DFIA 4HXXA 4U69A 4FKCA 2V6CA 3MR1A 3I7MA 2BHCA 2HOWA 3BIPA 3FMRA 1XNZA 2V3XA 4IU6A 4KM3A 5FCFA 3IU7A 3OOOA 4RGZ1 3PN9A 4U76A 1C27A 2BHDA 4IDYA 4U70A 2NQ7A 5CNXA 3FMQA 4FLKA 3CB5A 2B3LA 4FO7A 2GA2A 4IKTA 1QZYA 4B28A 4A6WA 2EVMA 1O0XA 4U6ZA 3D27A 1C22A 2EVOA 2BHAA 3IL0A 2GG0A 3IU9A 4R60A 4ZWPA 1C24A 1YW7A 3BIQA 1JAWA 1R5GA 5CIKA 4IKRA 2BN7A 1QXWA 4S2RP 2BWXA 1YVMA 4IPAA 4FLLA 2GG2A 3PKBA 2GU6A 4U1BA 3FM3A 1KQ9A 1WL6A
chains in the Genus database with same CATH topology
1MATA 1C23A 1XGNA 2GG7A 2P99A 4RZZA 5CDLA 2Q93A 4IECA 5CDEA 4QR8A 2GGBA 5JFRA 5CLSA 2BHBA 2GG3A 5E2CA 4FLIA 5JI6A 3IU8A 5D6FA 2P98A 2BWSA 3QOCA 4FLJA 4U71A 1QXZA 2MATA 1YW8A 4S00A 1B6AA 1N51A 1KP0A 2GG5A 1PV9A 4MATA 1WY2A 4U73A 3L7GA 3MATA 3O5VA 3Q6DA 4FUKA 2V3YA 2BWYA 2EA4A 1W2MA 2GGCA 2GTXA 2GU5A 2Q95A 4IKSA 1BN5A 4U6JA 1BOAA 2ADUA 5E5BA 2Q94A 2P9AA 4ZNGA 1XGMA 1WBQA 2EVCA 3BITA 4U6WA 2Q96A 1R58A 5D6EA 3RORA 4EGEA 3L24A 1YW9A 4JUQA 4PNCA 4U6EA 1CHMA 3PKDA 2Q92A 3MX6A 1M35A 3TAVA 3RVAA 3S6BA 2GG8A 2BWUA 1W7VA 2GU7A 4IKUA 1B59A 4S2TP 2GG9A 2IW2A 2ZSGA 4Z7MA 3IG4A 3OVKA 2EA2A 4U75A 2BH3A 2V3ZA 3PEBA 1C21A 4IF7A 1R5HA 5CE6A 2Q8KA 1WN1A 4S01A 3PKCA 5FCHA 3PKAA 1QXYA 5CDVA 2BWWA 1WLRA 1Y1NA 1A16A 1KQ0A 4OOKA 3CTZA 2GU4A 2B3HA 4U6CA 1WKMA 3TB5A 3CB6A 2OKNA 4FO8A 2GZ5A 2G6PA 2B3KA 4ZWOA 4ZWUA 1YJ3A 4A6VA 3PKEA 1XGSA 4PV4A 1WL9A 4RZYA 2NQ6A 2BWVA 2OAZA 1XGOA 2BB7A 2BWTA 5JHUA 2DFIA 4HXXA 4U69A 4FKCA 2V6CA 3MR1A 3I7MA 2BHCA 2HOWA 3BIPA 3FMRA 1XNZA 2V3XA 4IU6A 4KM3A 5FCFA 3IU7A 3OOOA 4RGZ1 3PN9A 4U76A 1C27A 2BHDA 4IDYA 4U70A 2NQ7A 5CNXA 3FMQA 4FLKA 3CB5A 2B3LA 4FO7A 2GA2A 4IKTA 1QZYA 4B28A 4A6WA 2EVMA 1O0XA 4U6ZA 3D27A 1C22A 2EVOA 2BHAA 3IL0A 2GG0A 3IU9A 4R60A 4ZWPA 1C24A 1YW7A 3BIQA 1JAWA 1R5GA 5CIKA 4IKRA 2BN7A 1QXWA 4S2RP 2BWXA 1YVMA 4IPAA 4FLLA 2GG2A 3PKBA 2GU6A 4U1BA 3FM3A 1KQ9A 1WL6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MAT A;  1C23 A;  1XGN A;  2GG7 A;  2P99 A;  4RZZ A;  5CDL A;  2Q93 A;  4IEC A;  5CDE A;  4QR8 A;  2GGB A;  5JFR A;  5CLS A;  2BHB A;  2GG3 A;  5E2C A;  4FLI A;  5JI6 A;  3IU8 A;  5D6F A;  2P98 A;  2BWS A;  3QOC A;  4FLJ A;  4U71 A;  1QXZ A;  2MAT A;  1YW8 A;  4S00 A;  1B6A A;  1N51 A;  1KP0 A;  2GG5 A;  1PV9 A;  4MAT A;  1WY2 A;  4U73 A;  3L7G A;  3MAT A;  3O5V A;  3Q6D A;  4FUK A;  2V3Y A;  2BWY A;  2EA4 A;  1W2M A;  2GGC A;  2GTX A;  2GU5 A;  2Q95 A;  4IKS A;  1BN5 A;  4U6J A;  1BOA A;  2ADU A;  5E5B A;  2Q94 A;  2P9A A;  4ZNG A;  1XGM A;  1WBQ A;  2EVC A;  3BIT A;  4U6W A;  2Q96 A;  1R58 A;  5D6E A;  3ROR A;  4EGE A;  3L24 A;  1YW9 A;  4JUQ A;  4PNC A;  4U6E A;  1CHM A;  3PKD A;  2Q92 A;  3MX6 A;  1M35 A;  3TAV A;  3RVA A;  3S6B A;  2GG8 A;  2BWU A;  1W7V A;  2GU7 A;  4IKU A;  1B59 A;  4S2T P;  2GG9 A;  2IW2 A;  2ZSG A;  4Z7M A;  3IG4 A;  3OVK A;  2EA2 A;  4U75 A;  2BH3 A;  2V3Z A;  3PEB A;  1C21 A;  4IF7 A;  1R5H A;  5CE6 A;  2Q8K A;  1WN1 A;  4S01 A;  3PKC A;  5FCH A;  3PKA A;  1QXY A;  5CDV A;  2BWW A;  1WLR A;  1Y1N A;  1A16 A;  1KQ0 A;  4OOK A;  3CTZ A;  2GU4 A;  2B3H A;  4U6C A;  1WKM A;  3TB5 A;  3CB6 A;  2OKN A;  4FO8 A;  2GZ5 A;  2G6P A;  2B3K A;  4ZWO A;  4ZWU A;  1YJ3 A;  4A6V A;  3PKE A;  1XGS A;  4PV4 A;  1WL9 A;  4RZY A;  2NQ6 A;  2BWV A;  2OAZ A;  1XGO A;  2BB7 A;  2BWT A;  5JHU A;  2DFI A;  4HXX A;  4U69 A;  4FKC A;  2V6C A;  3MR1 A;  3I7M A;  2BHC A;  2HOW A;  3BIP A;  3FMR A;  1XNZ A;  2V3X A;  4IU6 A;  4KM3 A;  5FCF A;  3IU7 A;  3OOO A;  4RGZ 1;  3PN9 A;  4U76 A;  1C27 A;  2BHD A;  4IDY A;  4U70 A;  2NQ7 A;  5CNX A;  3FMQ A;  4FLK A;  3CB5 A;  2B3L A;  4FO7 A;  2GA2 A;  4IKT A;  1QZY A;  4B28 A;  4A6W A;  2EVM A;  1O0X A;  4U6Z A;  3D27 A;  1C22 A;  2EVO A;  2BHA A;  3IL0 A;  2GG0 A;  3IU9 A;  4R60 A;  4ZWP A;  1C24 A;  1YW7 A;  3BIQ A;  1JAW A;  1R5G A;  5CIK A;  4IKR A;  2BN7 A;  1QXW A;  4S2R P;  2BWX A;  1YVM A;  4IPA A;  4FLL A;  2GG2 A;  3PKB A;  2GU6 A;  4U1B A;  3FM3 A;  1KQ9 A;  1WL6 A; 
#chains in the Genus database with same CATH topology
 1MAT A;  1C23 A;  1XGN A;  2GG7 A;  2P99 A;  4RZZ A;  5CDL A;  2Q93 A;  4IEC A;  5CDE A;  4QR8 A;  2GGB A;  5JFR A;  5CLS A;  2BHB A;  2GG3 A;  5E2C A;  4FLI A;  5JI6 A;  3IU8 A;  5D6F A;  2P98 A;  2BWS A;  3QOC A;  4FLJ A;  4U71 A;  1QXZ A;  2MAT A;  1YW8 A;  4S00 A;  1B6A A;  1N51 A;  1KP0 A;  2GG5 A;  1PV9 A;  4MAT A;  1WY2 A;  4U73 A;  3L7G A;  3MAT A;  3O5V A;  3Q6D A;  4FUK A;  2V3Y A;  2BWY A;  2EA4 A;  1W2M A;  2GGC A;  2GTX A;  2GU5 A;  2Q95 A;  4IKS A;  1BN5 A;  4U6J A;  1BOA A;  2ADU A;  5E5B A;  2Q94 A;  2P9A A;  4ZNG A;  1XGM A;  1WBQ A;  2EVC A;  3BIT A;  4U6W A;  2Q96 A;  1R58 A;  5D6E A;  3ROR A;  4EGE A;  3L24 A;  1YW9 A;  4JUQ A;  4PNC A;  4U6E A;  1CHM A;  3PKD A;  2Q92 A;  3MX6 A;  1M35 A;  3TAV A;  3RVA A;  3S6B A;  2GG8 A;  2BWU A;  1W7V A;  2GU7 A;  4IKU A;  1B59 A;  4S2T P;  2GG9 A;  2IW2 A;  2ZSG A;  4Z7M A;  3IG4 A;  3OVK A;  2EA2 A;  4U75 A;  2BH3 A;  2V3Z A;  3PEB A;  1C21 A;  4IF7 A;  1R5H A;  5CE6 A;  2Q8K A;  1WN1 A;  4S01 A;  3PKC A;  5FCH A;  3PKA A;  1QXY A;  5CDV A;  2BWW A;  1WLR A;  1Y1N A;  1A16 A;  1KQ0 A;  4OOK A;  3CTZ A;  2GU4 A;  2B3H A;  4U6C A;  1WKM A;  3TB5 A;  3CB6 A;  2OKN A;  4FO8 A;  2GZ5 A;  2G6P A;  2B3K A;  4ZWO A;  4ZWU A;  1YJ3 A;  4A6V A;  3PKE A;  1XGS A;  4PV4 A;  1WL9 A;  4RZY A;  2NQ6 A;  2BWV A;  2OAZ A;  1XGO A;  2BB7 A;  2BWT A;  5JHU A;  2DFI A;  4HXX A;  4U69 A;  4FKC A;  2V6C A;  3MR1 A;  3I7M A;  2BHC A;  2HOW A;  3BIP A;  3FMR A;  1XNZ A;  2V3X A;  4IU6 A;  4KM3 A;  5FCF A;  3IU7 A;  3OOO A;  4RGZ 1;  3PN9 A;  4U76 A;  1C27 A;  2BHD A;  4IDY A;  4U70 A;  2NQ7 A;  5CNX A;  3FMQ A;  4FLK A;  3CB5 A;  2B3L A;  4FO7 A;  2GA2 A;  4IKT A;  1QZY A;  4B28 A;  4A6W A;  2EVM A;  1O0X A;  4U6Z A;  3D27 A;  1C22 A;  2EVO A;  2BHA A;  3IL0 A;  2GG0 A;  3IU9 A;  4R60 A;  4ZWP A;  1C24 A;  1YW7 A;  3BIQ A;  1JAW A;  1R5G A;  5CIK A;  4IKR A;  2BN7 A;  1QXW A;  4S2R P;  2BWX A;  1YVM A;  4IPA A;  4FLL A;  2GG2 A;  3PKB A;  2GU6 A;  4U1B A;  3FM3 A;  1KQ9 A;  1WL6 A; 
#chains in the Genus database with same CATH homology
 1MAT A;  1C23 A;  1XGN A;  2GG7 A;  2P99 A;  4RZZ A;  5CDL A;  2Q93 A;  4IEC A;  5CDE A;  4QR8 A;  2GGB A;  5JFR A;  5CLS A;  2BHB A;  2GG3 A;  5E2C A;  4FLI A;  5JI6 A;  3IU8 A;  5D6F A;  2P98 A;  2BWS A;  3QOC A;  4FLJ A;  4U71 A;  1QXZ A;  2MAT A;  1YW8 A;  4S00 A;  1B6A A;  1N51 A;  1KP0 A;  2GG5 A;  1PV9 A;  4MAT A;  1WY2 A;  4U73 A;  3L7G A;  3MAT A;  3O5V A;  3Q6D A;  4FUK A;  2V3Y A;  2BWY A;  2EA4 A;  1W2M A;  2GGC A;  2GTX A;  2GU5 A;  2Q95 A;  4IKS A;  1BN5 A;  4U6J A;  1BOA A;  2ADU A;  5E5B A;  2Q94 A;  2P9A A;  4ZNG A;  1XGM A;  1WBQ A;  2EVC A;  3BIT A;  4U6W A;  2Q96 A;  1R58 A;  5D6E A;  3ROR A;  4EGE A;  3L24 A;  1YW9 A;  4JUQ A;  4PNC A;  4U6E A;  1CHM A;  3PKD A;  2Q92 A;  3MX6 A;  1M35 A;  3TAV A;  3RVA A;  3S6B A;  2GG8 A;  2BWU A;  1W7V A;  2GU7 A;  4IKU A;  1B59 A;  4S2T P;  2GG9 A;  2IW2 A;  2ZSG A;  4Z7M A;  3IG4 A;  3OVK A;  2EA2 A;  4U75 A;  2BH3 A;  2V3Z A;  3PEB A;  1C21 A;  4IF7 A;  1R5H A;  5CE6 A;  2Q8K A;  1WN1 A;  4S01 A;  3PKC A;  5FCH A;  3PKA A;  1QXY A;  5CDV A;  2BWW A;  1WLR A;  1Y1N A;  1A16 A;  1KQ0 A;  4OOK A;  3CTZ A;  2GU4 A;  2B3H A;  4U6C A;  1WKM A;  3TB5 A;  3CB6 A;  2OKN A;  4FO8 A;  2GZ5 A;  2G6P A;  2B3K A;  4ZWO A;  4ZWU A;  1YJ3 A;  4A6V A;  3PKE A;  1XGS A;  4PV4 A;  1WL9 A;  4RZY A;  2NQ6 A;  2BWV A;  2OAZ A;  1XGO A;  2BB7 A;  2BWT A;  5JHU A;  2DFI A;  4HXX A;  4U69 A;  4FKC A;  2V6C A;  3MR1 A;  3I7M A;  2BHC A;  2HOW A;  3BIP A;  3FMR A;  1XNZ A;  2V3X A;  4IU6 A;  4KM3 A;  5FCF A;  3IU7 A;  3OOO A;  4RGZ 1;  3PN9 A;  4U76 A;  1C27 A;  2BHD A;  4IDY A;  4U70 A;  2NQ7 A;  5CNX A;  3FMQ A;  4FLK A;  3CB5 A;  2B3L A;  4FO7 A;  2GA2 A;  4IKT A;  1QZY A;  4B28 A;  4A6W A;  2EVM A;  1O0X A;  4U6Z A;  3D27 A;  1C22 A;  2EVO A;  2BHA A;  3IL0 A;  2GG0 A;  3IU9 A;  4R60 A;  4ZWP A;  1C24 A;  1YW7 A;  3BIQ A;  1JAW A;  1R5G A;  5CIK A;  4IKR A;  2BN7 A;  1QXW A;  4S2R P;  2BWX A;  1YVM A;  4IPA A;  4FLL A;  2GG2 A;  3PKB A;  2GU6 A;  4U1B A;  3FM3 A;  1KQ9 A;  1WL6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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