3LEAA

Crystal structure of the catalytic domain of tace with isoindolinone-biphenyl-hydantoin inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
258
structure length
258
Chain Sequence
DPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Biaryl substituted hydantoin compounds as TACE inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Disintegrin and metalloproteinase domain-containing protein
total genus 84
structure length 258
sequence length 258
chains with identical sequence B
ec nomenclature ec 3.4.24.86: ADAM 17 endopeptidase.
pdb deposition date 2010-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13688 Reprolysin_5 Metallo-peptidase family M12
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3leaA00
2WO9A 4L19A 5H8XA 1QJIA 3N2VA 3DPFA 4GWMA 4WF6A 3F16A 1QJJA 2PJTA 3LJZA 1G4KA 4AUOA 4XM7A 1BUDA 1UEAA 4JA1A 3TSKA 1XFVA 1OS9A 3KEJA 1H71P 2EROA 1YOUA 2W12A 1JKYA 2OVXA 1C7KA 3SHIA 3HYGA 5D3CA 1IABA 2I47A 2JIHA 2OXZA 1UTTA 2V4BA 1J7NA 3F15A 4XM8A 1RMZA 3LIKA 3LQBA 3KMCA 3ZXHA 3G5CA 4PKSA 3V96B 3HY7A 1R1HA 1MMQA 3DNGA 1ND1A 1JANA 1ZXCA 1AYKA 1YP1A 3AYKA 3LK8A 4XBHA 4WKIA 2RJPA 1SMPA 1YCMA 1D8FA 4FU4A 3BA0A 1UTZA 1JH1A 2W15A 3HY9A 4H82A 3LILA 2W0DA 5BOYA 2WO8A 3F18A 1GO8P 5CXAA 1IAAA 1G05A 4JIJA 1CIZA 2DDYA 3MA2A 2JT5A 4JP4A 3EHXA 1XUDA 2OY4A 5B5OA 1JAQA 2W13A 1AF0A 830CA 3LEAA 1R54A 3LE9A 1Z3JA 4ZR5A 2D1OA 3DWBA 4XM6A 1GKDA 1R1JA 1BQQM 2USNA 4H76A 2OW2A 1QIBA 4A3WA 3P1VA 3TS4A 1HY7A 3O2XA 3Q2GA 1GE7A 4DPEA 3F17A 3EDGA 4L63A 1PWVA 1B8YA 3TT4A 1C8TA 1XFYA 2X3BA 1XFXA 4AIGA 2DW0A 3NX7A 1PWPA 3USNA 4GR3A 2OXUA 5D1TA 2JT6A 3LUNA 3KMEA 3ELMA 1KUKA 4GQLA 4R3VA 3B8ZA 3F19A 3N2UA 1EUBA 456CA 1YQYA 1KUHA 1BQOA 1WNIA 1O0TA 2OY2A 4FVLA 4WK7A 1FBLA 2OW1A 1IACA 1MMPA 2KRJA 1ZVXA 2TCLA 1FM1A 2W14A 4H1QA 1BM6A 1IAEA 4AXQA 1GXDA 4GR0A 1XURA 1ASTA 1BZSA 3DL1A 1HFSA 5I3MA 1Q3AA 1K7QA 1USNA 2XS3A 3WV3A 1A86A 1CGEA 1L6JA 1BUVM 2D1NA 2WOAA 4H84A 5D7WA 2MZIA 2E2DA 3AIGA 1XFZA 3K7NA 4ILWD 2MZHA 3LJTA 2N8RA 3LIRA 1EAKA 1CAQA 2MZEA 3F1AA 3B2ZA 2OVZA 4H3XA 3KHIA 4H49A 5D2BA 4L6TA 1PWQA 3LMCA 4PKVA 3DPEA 1KUGA 2HU6A 4HMAA 4ON1A 1PWWA 2X3AA 5B5PA 1BKCA 1B3DA 1XFUA 4Q1LA 1MMRA 3KEKA 1BKCI 1ATLA 3Q2HA 2ERPA 1R1IA 4A7BA 1CK7A 1OMJA 4FXQA 1CQRA 3ZUKA 3EDIA 2QPJA 5BPAA 4HX3A 1HV5A 1GE6A 1GE5A 5D1UA 1R55A 1O0QA 1GKCA 1UMTA 1BIWA 3EHYA 1I76A 5CUHA 1XFWA 2L0RA 4G0DA 2ERQA 1KUFA 1KAPP 1D8MA 2RJQA 1QIAA 2POJA 1KUIA 3KRYA 3WV2A 4JQGA 1RM8A 3ZVSA 3RTTA 1EB6A 1K7GA 1Y0VA 4PKWA 1OM6A 3LJGA 1JAOA 1JAPA 2CKIA 1BKCE 2SRTA 2J83A 3U1RA 2YIGA 4H2EA 3AYUA 1AKLA 1Y8JA 2J0TA 4GR8A 5L7FA 1OM7A 3EWJA 3HDBA 3LGPA 2JSDA 1CGFA 5I12A 1MMBA 1SLNA 1IAGA 5L79A 4AYKA 4PKUA 1MNCA 3UVCA 5JMYA 3P24A 5LABA 5CZMA 5D1SA 1SRPA 1SATA 1S4BP 1ROSA 3GBOA 4I03A 4IN9A 3HBUP 2FV5A 1FLSA 1ZS0A 4IUWA 1CGLA 2Z2DA 3KWVC 3VTGA 2YB9A 1G9KA 2K2GA 1GO7P 1HTDA 1OO9A 5BOTA 1XUCA 1BSWA 2OW9A 4EFSA 2Y6CA 1K7IA 1SLMA 3WV1A 1IADA 4PKRA 966CA 2A8HA 4DF9A 4PKTA 4JPAA 2MLSA 4DD8A 1Y93A 3HDAP 4WZVA 2OI0A 3G42A 5I43A 4QKZA 4XCTA 2CLTA 1G49A 2DW2A 2XS4A 1UMSA 1HOVA 1C3IA 1SU3A 3OHLA 4GF1A 1A85A 2AYKA 4J4MA 4G9LA 2FV9A 3VI1A 1DTHA 2DDFA 4GUYA 1D7XA 4PKQA 1OS2A 1JK3A 1QUAA 5I2ZA 2DW1A 2X7MA 1CXVA 1ZTQA 3L0VA 2AIGP 1D5JA 1HFCA 1JIZA 3E8RA 2X3CA 2O3EA 1I1IP 1I73A 3LUMA 3LQ0A 2Y6DA 3I7IA 3EDHA 3I7GA 3O64A 2O36A 4H30A 3HB2P 1ZXVA 1JIWP 3K7LA 2OXWA 3EDZA 2OW0A 4GWNA 4I35A 3CKIA 3KECA 3L0TA 1PWUA 3RTSA 4FXYP 4WKEA 5I0LA 2JNPA 3LKAA 1OM8A 1QICA 2E3XA 4CTHA 3OHOA 4IJOA 1KBCA 5I4OA 3HBVP 3TVCA 3B92A 3DSLA 2K9CA 1DMTA 2MLRA 4DV8A 2OZRA 1JJ9A 1G12A 1ZP5A
chains in the Genus database with same CATH superfamily
2WO9A 4L19A 5H8XA 1QJIA 3N2VA 3DPFA 4GWMA 4WF6A 3F16A 1QJJA 3DTKA 2PJTA 3LJZA 1G4KA 4AUOA 4XM7A 1BUDA 1UEAA 4JA1A 3TSKA 1XFVA 1OS9A 3KEJA 1H71P 2EROA 1YOUA 2W12A 1JKYA 2OVXA 1C7KA 3SHIA 3HYGA 5D3CA 1IABA 2I47A 2JIHA 2OXZA 1UTTA 2V4BA 1J7NA 3F15A 4XM8A 1RMZA 3LIKA 3LQBA 3KMCA 3ZXHA 3G5CA 4PKSA 3V96B 3HY7A 1R1HA 1MMQA 3DNGA 1ND1A 1JANA 1ZXCA 1AYKA 1YP1A 3AYKA 3LK8A 4XBHA 4WKIA 2RJPA 1SMPA 1YCMA 1D8FA 1XAXA 4FU4A 3BA0A 1UTZA 1JH1A 2W15A 3HY9A 4H82A 3LILA 2W0DA 5BOYA 2WO8A 3F18A 1GO8P 5CXAA 1IAAA 1G05A 4JIJA 1CIZA 2DDYA 3MA2A 2JT5A 4JP4A 3EHXA 1XUDA 2OY4A 5B5OA 1JAQA 2W13A 1AF0A 830CA 3LEAA 1R54A 3LE9A 1Z3JA 4ZR5A 2D1OA 3DWBA 4XM6A 1GKDA 1R1JA 1BQQM 2USNA 4H76A 2OW2A 1QIBA 4A3WA 3P1VA 3TS4A 1HY7A 3O2XA 3Q2GA 1GE7A 4DPEA 3F17A 3EDGA 4L63A 1PWVA 1B8YA 3TT4A 1C8TA 1XFYA 2X3BA 1XFXA 4AIGA 2DW0A 3NX7A 1PWPA 3USNA 4GR3A 2OXUA 5D1TA 2JT6A 3LUNA 3KMEA 3ELMA 1KUKA 4GQLA 4R3VA 3B8ZA 3F19A 3N2UA 1EUBA 456CA 1YQYA 1KUHA 1BQOA 1WNIA 1O0TA 2OY2A 4FVLA 4WK7A 1FBLA 2OW1A 1IACA 1MMPA 2KRJA 1ZVXA 2TCLA 1FM1A 2W14A 4H1QA 1BM6A 1IAEA 4AXQA 1GXDA 4GR0A 1XURA 1ASTA 1BZSA 3DL1A 1HFSA 5I3MA 1Q3AA 1K7QA 1USNA 2XS3A 3WV3A 1A86A 1CGEA 1L6JA 1BUVM 2D1NA 2WOAA 4H84A 5D7WA 2MZIA 2E2DA 3AIGA 1XFZA 3K7NA 1OZ9A 4ILWD 2MZHA 3LJTA 3DTEA 2N8RA 3LIRA 1EAKA 1CAQA 2MZEA 3F1AA 3B2ZA 2OVZA 4H3XA 3KHIA 4H49A 5D2BA 4L6TA 1PWQA 3LMCA 4PKVA 3DPEA 1KUGA 2HU6A 4HMAA 4ON1A 1PWWA 2X3AA 5B5PA 1BKCA 1B3DA 1XFUA 4Q1LA 1MMRA 3KEKA 1BKCI 1ATLA 3Q2HA 2ERPA 1R1IA 4A7BA 1CK7A 1OMJA 4FXQA 1CQRA 3ZUKA 3EDIA 2QPJA 5BPAA 4HX3A 1HV5A 1GE6A 1GE5A 5D1UA 1R55A 1O0QA 1GKCA 1UMTA 1BIWA 3EHYA 1I76A 5CUHA 1XFWA 2L0RA 4G0DA 2ERQA 1KUFA 1KAPP 1D8MA 2RJQA 1QIAA 2POJA 1KUIA 3KRYA 3WV2A 4JQGA 1RM8A 3ZVSA 3RTTA 1EB6A 1K7GA 1Y0VA 4PKWA 1OM6A 3LJGA 1JAOA 1JAPA 2CKIA 1BKCE 2SRTA 2J83A 3U1RA 2YIGA 4H2EA 3AYUA 1AKLA 1Y8JA 2J0TA 4L7AA 4GR8A 5L7FA 1OM7A 3EWJA 3HDBA 3LGPA 1TVIA 2JSDA 1CGFA 5I12A 1MMBA 1SLNA 1IAGA 5L79A 4AYKA 4PKUA 1MNCA 3UVCA 5JMYA 3P24A 5LABA 5CZMA 5D1SA 1SRPA 1SATA 1S4BP 1ROSA 3GBOA 4I03A 4IN9A 3HBUP 2FV5A 1FLSA 1ZS0A 4IUWA 1CGLA 2Z2DA 3KWVC 3VTGA 2YB9A 1G9KA 2K2GA 1GO7P 1HTDA 1OO9A 5BOTA 1XUCA 1BSWA 2OW9A 4EFSA 2Y6CA 1K7IA 1SLMA 3WV1A 1IADA 4PKRA 966CA 2A8HA 4DF9A 4PKTA 4JPAA 2MLSA 4DD8A 1Y93A 3HDAP 4WZVA 2OI0A 3G42A 5I43A 4QKZA 4XCTA 2CLTA 1G49A 2DW2A 2XS4A 1UMSA 1HOVA 1C3IA 1SU3A 3OHLA 4GF1A 1A85A 2AYKA 4J4MA 4G9LA 2FV9A 3VI1A 1DTHA 2DDFA 4GUYA 1D7XA 4PKQA 1OS2A 1JK3A 1QUAA 5I2ZA 2DW1A 2X7MA 1CXVA 1ZTQA 3L0VA 2AIGP 1D5JA 1HFCA 1JIZA 3E8RA 2X3CA 2O3EA 1I1IP 1I73A 3LUMA 3LQ0A 2Y6DA 3I7IA 3EDHA 3I7GA 3O64A 2O36A 4H30A 3HB2P 1XM5A 1ZXVA 1JIWP 3K7LA 2OXWA 3EDZA 2OW0A 4GWNA 4I35A 3CKIA 3KECA 3L0TA 1PWUA 3RTSA 4FXYP 4WKEA 5I0LA 2JNPA 3DTIA 3LKAA 1OM8A 1QICA 2E3XA 4CTHA 3OHOA 4IJOA 1KBCA 5I4OA 3HBVP 2YUFA 3TVCA 3B92A 3DSLA 2K9CA 1DMTA 2MLRA 4DV8A 2OZRA 1JJ9A 1G12A 1ZP5A
chains in the Genus database with same CATH topology
2WO9A 4L19A 5H8XA 1QJIA 3N2VA 3DPFA 4GWMA 4WF6A 3F16A 1QJJA 3DTKA 2PJTA 3LJZA 1G4KA 4AUOA 4XM7A 1BUDA 1UEAA 4JA1A 3TSKA 1XFVA 1OS9A 3KEJA 1H71P 2EROA 1YOUA 2W12A 1JKYA 2OVXA 1C7KA 3SHIA 3HYGA 5D3CA 1IABA 2I47A 2JIHA 2OXZA 1UTTA 2V4BA 1J7NA 3F15A 4XM8A 1RMZA 3LIKA 3LQBA 3KMCA 3ZXHA 3G5CA 4PKSA 3V96B 3HY7A 1R1HA 1MMQA 3DNGA 1ND1A 1JANA 1ZXCA 1AYKA 1YP1A 3AYKA 3LK8A 4XBHA 4WKIA 2RJPA 1SMPA 1YCMA 1D8FA 4FU4A 3BA0A 1UTZA 1JH1A 2W15A 3HY9A 4H82A 3LILA 2W0DA 5BOYA 2WO8A 3F18A 1GO8P 5CXAA 1IAAA 1G05A 4JIJA 1CIZA 2DDYA 3MA2A 2JT5A 4JP4A 3EHXA 1XUDA 2OY4A 5B5OA 1JAQA 2W13A 1AF0A 830CA 3LEAA 1R54A 3LE9A 1Z3JA 4ZR5A 2D1OA 3DWBA 4XM6A 1GKDA 1R1JA 1BQQM 2USNA 4H76A 2OW2A 1QIBA 4A3WA 3P1VA 3TS4A 1HY7A 3O2XA 3Q2GA 1GE7A 4DPEA 3F17A 3EDGA 4L63A 1PWVA 1B8YA 3TT4A 1C8TA 1XFYA 2X3BA 1XFXA 4AIGA 2DW0A 3NX7A 1PWPA 3USNA 4GR3A 2OXUA 5D1TA 2JT6A 3LUNA 3KMEA 3ELMA 1KUKA 4GQLA 4R3VA 3B8ZA 3F19A 3N2UA 1EUBA 456CA 1YQYA 1KUHA 1BQOA 1WNIA 1O0TA 2OY2A 4FVLA 4WK7A 1FBLA 2OW1A 1IACA 1MMPA 2KRJA 1ZVXA 2TCLA 1FM1A 2W14A 4H1QA 1BM6A 1IAEA 4AXQA 1GXDA 4GR0A 1XURA 1ASTA 1BZSA 3DL1A 1HFSA 5I3MA 1Q3AA 1K7QA 1USNA 2XS3A 3WV3A 1A86A 1CGEA 1L6JA 1BUVM 2D1NA 2WOAA 4H84A 5D7WA 2MZIA 2E2DA 3AIGA 1XFZA 3K7NA 4ILWD 2MZHA 3LJTA 3DTEA 2N8RA 3LIRA 1EAKA 1CAQA 2MZEA 3F1AA 3B2ZA 2OVZA 4H3XA 3KHIA 4H49A 5D2BA 4L6TA 1PWQA 3LMCA 4PKVA 3DPEA 1KUGA 2HU6A 4HMAA 4ON1A 1PWWA 2X3AA 5B5PA 1BKCA 1B3DA 1XFUA 4Q1LA 1MMRA 3KEKA 1BKCI 1ATLA 3Q2HA 2ERPA 1R1IA 4A7BA 1CK7A 1OMJA 4FXQA 1CQRA 3ZUKA 3EDIA 2QPJA 5BPAA 4HX3A 1HV5A 1GE6A 1GE5A 5D1UA 1R55A 1O0QA 1GKCA 1UMTA 1BIWA 3EHYA 1I76A 5CUHA 1XFWA 2L0RA 4G0DA 2ERQA 1KUFA 1KAPP 1D8MA 2RJQA 1QIAA 2POJA 1KUIA 3KRYA 3WV2A 4JQGA 1RM8A 3ZVSA 3RTTA 1EB6A 1K7GA 1Y0VA 4PKWA 1OM6A 3LJGA 1JAOA 1JAPA 2CKIA 1BKCE 2SRTA 2J83A 3U1RA 2YIGA 4H2EA 3AYUA 1AKLA 1Y8JA 2J0TA 4L7AA 4GR8A 5L7FA 1OM7A 3EWJA 3HDBA 3LGPA 2JSDA 1CGFA 5I12A 1MMBA 1SLNA 1IAGA 5L79A 4AYKA 4PKUA 1MNCA 3UVCA 5JMYA 3P24A 5LABA 5CZMA 5D1SA 1SRPA 1SATA 1S4BP 1ROSA 3GBOA 4I03A 4IN9A 3HBUP 2FV5A 1FLSA 1ZS0A 4IUWA 1CGLA 2Z2DA 3KWVC 3VTGA 2YB9A 1G9KA 2K2GA 1GO7P 1HTDA 1OO9A 5BOTA 1XUCA 1BSWA 2OW9A 4EFSA 2Y6CA 1K7IA 1SLMA 3WV1A 1IADA 4PKRA 966CA 2A8HA 4DF9A 4PKTA 4JPAA 2MLSA 4DD8A 1Y93A 3HDAP 4WZVA 2OI0A 3G42A 5I43A 4QKZA 4XCTA 2CLTA 1G49A 2DW2A 2XS4A 1UMSA 1HOVA 1C3IA 1SU3A 3OHLA 4GF1A 1A85A 2AYKA 4J4MA 4G9LA 2FV9A 3VI1A 1DTHA 2DDFA 4GUYA 1D7XA 4PKQA 1OS2A 1JK3A 1QUAA 5I2ZA 2DW1A 2X7MA 1CXVA 1ZTQA 3L0VA 2AIGP 1D5JA 1HFCA 1JIZA 3E8RA 2X3CA 2O3EA 1I1IP 1I73A 3LUMA 3LQ0A 2Y6DA 3I7IA 3EDHA 3I7GA 3O64A 2O36A 4H30A 3HB2P 1ZXVA 1JIWP 3K7LA 2OXWA 3EDZA 2OW0A 4GWNA 4I35A 3CKIA 3KECA 3L0TA 1PWUA 3RTSA 4FXYP 4WKEA 5I0LA 2JNPA 3DTIA 3LKAA 1OM8A 1QICA 2E3XA 4CTHA 3OHOA 4IJOA 1KBCA 5I4OA 3HBVP 2YUFA 3TVCA 3B92A 3DSLA 2K9CA 1DMTA 2MLRA 4DV8A 2OZRA 1JJ9A 1G12A 1ZP5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WO9 A;  4L19 A;  5H8X A;  1QJI A;  3N2V A;  3DPF A;  4GWM A;  4WF6 A;  3F16 A;  1QJJ A;  2PJT A;  3LJZ A;  1G4K A;  4AUO A;  4XM7 A;  1BUD A;  1UEA A;  4JA1 A;  3TSK A;  1XFV A;  1OS9 A;  3KEJ A;  1H71 P;  2ERO A;  1YOU A;  2W12 A;  1JKY A;  2OVX A;  1C7K A;  3SHI A;  3HYG A;  5D3C A;  1IAB A;  2I47 A;  2JIH A;  2OXZ A;  1UTT A;  2V4B A;  1J7N A;  3F15 A;  4XM8 A;  1RMZ A;  3LIK A;  3LQB A;  3KMC A;  3ZXH A;  3G5C A;  4PKS A;  3V96 B;  3HY7 A;  1R1H A;  1MMQ A;  3DNG A;  1ND1 A;  1JAN A;  1ZXC A;  1AYK A;  1YP1 A;  3AYK A;  3LK8 A;  4XBH A;  4WKI A;  2RJP A;  1SMP A;  1YCM A;  1D8F A;  4FU4 A;  3BA0 A;  1UTZ A;  1JH1 A;  2W15 A;  3HY9 A;  4H82 A;  3LIL A;  2W0D A;  5BOY A;  2WO8 A;  3F18 A;  1GO8 P;  5CXA A;  1IAA A;  1G05 A;  4JIJ A;  1CIZ A;  2DDY A;  3MA2 A;  2JT5 A;  4JP4 A;  3EHX A;  1XUD A;  2OY4 A;  5B5O A;  1JAQ A;  2W13 A;  1AF0 A;  830C A;  3LEA A;  1R54 A;  3LE9 A;  1Z3J A;  4ZR5 A;  2D1O A;  3DWB A;  4XM6 A;  1GKD A;  1R1J A;  1BQQ M;  2USN A;  4H76 A;  2OW2 A;  1QIB A;  4A3W A;  3P1V A;  3TS4 A;  1HY7 A;  3O2X A;  3Q2G A;  1GE7 A;  4DPE A;  3F17 A;  3EDG A;  4L63 A;  1PWV A;  1B8Y A;  3TT4 A;  1C8T A;  1XFY A;  2X3B A;  1XFX A;  4AIG A;  2DW0 A;  3NX7 A;  1PWP A;  3USN A;  4GR3 A;  2OXU A;  5D1T A;  2JT6 A;  3LUN A;  3KME A;  3ELM A;  1KUK A;  4GQL A;  4R3V A;  3B8Z A;  3F19 A;  3N2U A;  1EUB A;  456C A;  1YQY A;  1KUH A;  1BQO A;  1WNI A;  1O0T A;  2OY2 A;  4FVL A;  4WK7 A;  1FBL A;  2OW1 A;  1IAC A;  1MMP A;  2KRJ A;  1ZVX A;  2TCL A;  1FM1 A;  2W14 A;  4H1Q A;  1BM6 A;  1IAE A;  4AXQ A;  1GXD A;  4GR0 A;  1XUR A;  1AST A;  1BZS A;  3DL1 A;  1HFS A;  5I3M A;  1Q3A A;  1K7Q A;  1USN A;  2XS3 A;  3WV3 A;  1A86 A;  1CGE A;  1L6J A;  1BUV M;  2D1N A;  2WOA A;  4H84 A;  5D7W A;  2MZI A;  2E2D A;  3AIG A;  1XFZ A;  3K7N A;  4ILW D;  2MZH A;  3LJT A;  2N8R A;  3LIR A;  1EAK A;  1CAQ A;  2MZE A;  3F1A A;  3B2Z A;  2OVZ A;  4H3X A;  3KHI A;  4H49 A;  5D2B A;  4L6T A;  1PWQ A;  3LMC A;  4PKV A;  3DPE A;  1KUG A;  2HU6 A;  4HMA A;  4ON1 A;  1PWW A;  2X3A A;  5B5P A;  1BKC A;  1B3D A;  1XFU A;  4Q1L A;  1MMR A;  3KEK A;  1BKC I;  1ATL A;  3Q2H A;  2ERP A;  1R1I A;  4A7B A;  1CK7 A;  1OMJ A;  4FXQ A;  1CQR A;  3ZUK A;  3EDI A;  2QPJ A;  5BPA A;  4HX3 A;  1HV5 A;  1GE6 A;  1GE5 A;  5D1U A;  1R55 A;  1O0Q A;  1GKC A;  1UMT A;  1BIW A;  3EHY A;  1I76 A;  5CUH A;  1XFW A;  2L0R A;  4G0D A;  2ERQ A;  1KUF A;  1KAP P;  1D8M A;  2RJQ A;  1QIA A;  2POJ A;  1KUI A;  3KRY A;  3WV2 A;  4JQG A;  1RM8 A;  3ZVS A;  3RTT A;  1EB6 A;  1K7G A;  1Y0V A;  4PKW A;  1OM6 A;  3LJG A;  1JAO A;  1JAP A;  2CKI A;  1BKC E;  2SRT A;  2J83 A;  3U1R A;  2YIG A;  4H2E A;  3AYU A;  1AKL A;  1Y8J A;  2J0T A;  4GR8 A;  5L7F A;  1OM7 A;  3EWJ A;  3HDB A;  3LGP A;  2JSD A;  1CGF A;  5I12 A;  1MMB A;  1SLN A;  1IAG A;  5L79 A;  4AYK A;  4PKU A;  1MNC A;  3UVC A;  5JMY A;  3P24 A;  5LAB A;  5CZM A;  5D1S A;  1SRP A;  1SAT A;  1S4B P;  1ROS A;  3GBO A;  4I03 A;  4IN9 A;  3HBU P;  2FV5 A;  1FLS A;  1ZS0 A;  4IUW A;  1CGL A;  2Z2D A;  3KWV C;  3VTG A;  2YB9 A;  1G9K A;  2K2G A;  1GO7 P;  1HTD A;  1OO9 A;  5BOT A;  1XUC A;  1BSW A;  2OW9 A;  4EFS A;  2Y6C A;  1K7I A;  1SLM A;  3WV1 A;  1IAD A;  4PKR A;  966C A;  2A8H A;  4DF9 A;  4PKT A;  4JPA A;  2MLS A;  4DD8 A;  1Y93 A;  3HDA P;  4WZV A;  2OI0 A;  3G42 A;  5I43 A;  4QKZ A;  4XCT A;  2CLT A;  1G49 A;  2DW2 A;  2XS4 A;  1UMS A;  1HOV A;  1C3I A;  1SU3 A;  3OHL A;  4GF1 A;  1A85 A;  2AYK A;  4J4M A;  4G9L A;  2FV9 A;  3VI1 A;  1DTH A;  2DDF A;  4GUY A;  1D7X A;  4PKQ A;  1OS2 A;  1JK3 A;  1QUA A;  5I2Z A;  2DW1 A;  2X7M A;  1CXV A;  1ZTQ A;  3L0V A;  2AIG P;  1D5J A;  1HFC A;  1JIZ A;  3E8R A;  2X3C A;  2O3E A;  1I1I P;  1I73 A;  3LUM A;  3LQ0 A;  2Y6D A;  3I7I A;  3EDH A;  3I7G A;  3O64 A;  2O36 A;  4H30 A;  3HB2 P;  1ZXV A;  1JIW P;  3K7L A;  2OXW A;  3EDZ A;  2OW0 A;  4GWN A;  4I35 A;  3CKI A;  3KEC A;  3L0T A;  1PWU A;  3RTS A;  4FXY P;  4WKE A;  5I0L A;  2JNP A;  3LKA A;  1OM8 A;  1QIC A;  2E3X A;  4CTH A;  3OHO A;  4IJO A;  1KBC A;  5I4O A;  3HBV P;  3TVC A;  3B92 A;  3DSL A;  2K9C A;  1DMT A;  2MLR A;  4DV8 A;  2OZR A;  1JJ9 A;  1G12 A;  1ZP5 A; 
#chains in the Genus database with same CATH topology
 2WO9 A;  4L19 A;  5H8X A;  1QJI A;  3N2V A;  3DPF A;  4GWM A;  4WF6 A;  3F16 A;  1QJJ A;  3DTK A;  2PJT A;  3LJZ A;  1G4K A;  4AUO A;  4XM7 A;  1BUD A;  1UEA A;  4JA1 A;  3TSK A;  1XFV A;  1OS9 A;  3KEJ A;  1H71 P;  2ERO A;  1YOU A;  2W12 A;  1JKY A;  2OVX A;  1C7K A;  3SHI A;  3HYG A;  5D3C A;  1IAB A;  2I47 A;  2JIH A;  2OXZ A;  1UTT A;  2V4B A;  1J7N A;  3F15 A;  4XM8 A;  1RMZ A;  3LIK A;  3LQB A;  3KMC A;  3ZXH A;  3G5C A;  4PKS A;  3V96 B;  3HY7 A;  1R1H A;  1MMQ A;  3DNG A;  1ND1 A;  1JAN A;  1ZXC A;  1AYK A;  1YP1 A;  3AYK A;  3LK8 A;  4XBH A;  4WKI A;  2RJP A;  1SMP A;  1YCM A;  1D8F A;  1XAX A;  4FU4 A;  3BA0 A;  1UTZ A;  1JH1 A;  2W15 A;  3HY9 A;  4H82 A;  3LIL A;  2W0D A;  5BOY A;  2WO8 A;  3F18 A;  1GO8 P;  5CXA A;  1IAA A;  1G05 A;  4JIJ A;  1CIZ A;  2DDY A;  3MA2 A;  2JT5 A;  4JP4 A;  3EHX A;  1XUD A;  2OY4 A;  5B5O A;  1JAQ A;  2W13 A;  1AF0 A;  830C A;  3LEA A;  1R54 A;  3LE9 A;  1Z3J A;  4ZR5 A;  2D1O A;  3DWB A;  4XM6 A;  1GKD A;  1R1J A;  1BQQ M;  2USN A;  4H76 A;  2OW2 A;  1QIB A;  4A3W A;  3P1V A;  3TS4 A;  1HY7 A;  3O2X A;  3Q2G A;  1GE7 A;  4DPE A;  3F17 A;  3EDG A;  4L63 A;  1PWV A;  1B8Y A;  3TT4 A;  1C8T A;  1XFY A;  2X3B A;  1XFX A;  4AIG A;  2DW0 A;  3NX7 A;  1PWP A;  3USN A;  4GR3 A;  2OXU A;  5D1T A;  2JT6 A;  3LUN A;  3KME A;  3ELM A;  1KUK A;  4GQL A;  4R3V A;  3B8Z A;  3F19 A;  3N2U A;  1EUB A;  456C A;  1YQY A;  1KUH A;  1BQO A;  1WNI A;  1O0T A;  2OY2 A;  4FVL A;  4WK7 A;  1FBL A;  2OW1 A;  1IAC A;  1MMP A;  2KRJ A;  1ZVX A;  2TCL A;  1FM1 A;  2W14 A;  4H1Q A;  1BM6 A;  1IAE A;  4AXQ A;  1GXD A;  4GR0 A;  1XUR A;  1AST A;  1BZS A;  3DL1 A;  1HFS A;  5I3M A;  1Q3A A;  1K7Q A;  1USN A;  2XS3 A;  3WV3 A;  1A86 A;  1CGE A;  1L6J A;  1BUV M;  2D1N A;  2WOA A;  4H84 A;  5D7W A;  2MZI A;  2E2D A;  3AIG A;  1XFZ A;  3K7N A;  1OZ9 A;  4ILW D;  2MZH A;  3LJT A;  3DTE A;  2N8R A;  3LIR A;  1EAK A;  1CAQ A;  2MZE A;  3F1A A;  3B2Z A;  2OVZ A;  4H3X A;  3KHI A;  4H49 A;  5D2B A;  4L6T A;  1PWQ A;  3LMC A;  4PKV A;  3DPE A;  1KUG A;  2HU6 A;  4HMA A;  4ON1 A;  1PWW A;  2X3A A;  5B5P A;  1BKC A;  1B3D A;  1XFU A;  4Q1L A;  1MMR A;  3KEK A;  1BKC I;  1ATL A;  3Q2H A;  2ERP A;  1R1I A;  4A7B A;  1CK7 A;  1OMJ A;  4FXQ A;  1CQR A;  3ZUK A;  3EDI A;  2QPJ A;  5BPA A;  4HX3 A;  1HV5 A;  1GE6 A;  1GE5 A;  5D1U A;  1R55 A;  1O0Q A;  1GKC A;  1UMT A;  1BIW A;  3EHY A;  1I76 A;  5CUH A;  1XFW A;  2L0R A;  4G0D A;  2ERQ A;  1KUF A;  1KAP P;  1D8M A;  2RJQ A;  1QIA A;  2POJ A;  1KUI A;  3KRY A;  3WV2 A;  4JQG A;  1RM8 A;  3ZVS A;  3RTT A;  1EB6 A;  1K7G A;  1Y0V A;  4PKW A;  1OM6 A;  3LJG A;  1JAO A;  1JAP A;  2CKI A;  1BKC E;  2SRT A;  2J83 A;  3U1R A;  2YIG A;  4H2E A;  3AYU A;  1AKL A;  1Y8J A;  2J0T A;  4L7A A;  4GR8 A;  5L7F A;  1OM7 A;  3EWJ A;  3HDB A;  3LGP A;  1TVI A;  2JSD A;  1CGF A;  5I12 A;  1MMB A;  1SLN A;  1IAG A;  5L79 A;  4AYK A;  4PKU A;  1MNC A;  3UVC A;  5JMY A;  3P24 A;  5LAB A;  5CZM A;  5D1S A;  1SRP A;  1SAT A;  1S4B P;  1ROS A;  3GBO A;  4I03 A;  4IN9 A;  3HBU P;  2FV5 A;  1FLS A;  1ZS0 A;  4IUW A;  1CGL A;  2Z2D A;  3KWV C;  3VTG A;  2YB9 A;  1G9K A;  2K2G A;  1GO7 P;  1HTD A;  1OO9 A;  5BOT A;  1XUC A;  1BSW A;  2OW9 A;  4EFS A;  2Y6C A;  1K7I A;  1SLM A;  3WV1 A;  1IAD A;  4PKR A;  966C A;  2A8H A;  4DF9 A;  4PKT A;  4JPA A;  2MLS A;  4DD8 A;  1Y93 A;  3HDA P;  4WZV A;  2OI0 A;  3G42 A;  5I43 A;  4QKZ A;  4XCT A;  2CLT A;  1G49 A;  2DW2 A;  2XS4 A;  1UMS A;  1HOV A;  1C3I A;  1SU3 A;  3OHL A;  4GF1 A;  1A85 A;  2AYK A;  4J4M A;  4G9L A;  2FV9 A;  3VI1 A;  1DTH A;  2DDF A;  4GUY A;  1D7X A;  4PKQ A;  1OS2 A;  1JK3 A;  1QUA A;  5I2Z A;  2DW1 A;  2X7M A;  1CXV A;  1ZTQ A;  3L0V A;  2AIG P;  1D5J A;  1HFC A;  1JIZ A;  3E8R A;  2X3C A;  2O3E A;  1I1I P;  1I73 A;  3LUM A;  3LQ0 A;  2Y6D A;  3I7I A;  3EDH A;  3I7G A;  3O64 A;  2O36 A;  4H30 A;  3HB2 P;  1XM5 A;  1ZXV A;  1JIW P;  3K7L A;  2OXW A;  3EDZ A;  2OW0 A;  4GWN A;  4I35 A;  3CKI A;  3KEC A;  3L0T A;  1PWU A;  3RTS A;  4FXY P;  4WKE A;  5I0L A;  2JNP A;  3DTI A;  3LKA A;  1OM8 A;  1QIC A;  2E3X A;  4CTH A;  3OHO A;  4IJO A;  1KBC A;  5I4O A;  3HBV P;  2YUF A;  3TVC A;  3B92 A;  3DSL A;  2K9C A;  1DMT A;  2MLR A;  4DV8 A;  2OZR A;  1JJ9 A;  1G12 A;  1ZP5 A; 
#chains in the Genus database with same CATH homology
 2WO9 A;  4L19 A;  5H8X A;  1QJI A;  3N2V A;  3DPF A;  4GWM A;  4WF6 A;  3F16 A;  1QJJ A;  3DTK A;  2PJT A;  3LJZ A;  1G4K A;  4AUO A;  4XM7 A;  1BUD A;  1UEA A;  4JA1 A;  3TSK A;  1XFV A;  1OS9 A;  3KEJ A;  1H71 P;  2ERO A;  1YOU A;  2W12 A;  1JKY A;  2OVX A;  1C7K A;  3SHI A;  3HYG A;  5D3C A;  1IAB A;  2I47 A;  2JIH A;  2OXZ A;  1UTT A;  2V4B A;  1J7N A;  3F15 A;  4XM8 A;  1RMZ A;  3LIK A;  3LQB A;  3KMC A;  3ZXH A;  3G5C A;  4PKS A;  3V96 B;  3HY7 A;  1R1H A;  1MMQ A;  3DNG A;  1ND1 A;  1JAN A;  1ZXC A;  1AYK A;  1YP1 A;  3AYK A;  3LK8 A;  4XBH A;  4WKI A;  2RJP A;  1SMP A;  1YCM A;  1D8F A;  4FU4 A;  3BA0 A;  1UTZ A;  1JH1 A;  2W15 A;  3HY9 A;  4H82 A;  3LIL A;  2W0D A;  5BOY A;  2WO8 A;  3F18 A;  1GO8 P;  5CXA A;  1IAA A;  1G05 A;  4JIJ A;  1CIZ A;  2DDY A;  3MA2 A;  2JT5 A;  4JP4 A;  3EHX A;  1XUD A;  2OY4 A;  5B5O A;  1JAQ A;  2W13 A;  1AF0 A;  830C A;  3LEA A;  1R54 A;  3LE9 A;  1Z3J A;  4ZR5 A;  2D1O A;  3DWB A;  4XM6 A;  1GKD A;  1R1J A;  1BQQ M;  2USN A;  4H76 A;  2OW2 A;  1QIB A;  4A3W A;  3P1V A;  3TS4 A;  1HY7 A;  3O2X A;  3Q2G A;  1GE7 A;  4DPE A;  3F17 A;  3EDG A;  4L63 A;  1PWV A;  1B8Y A;  3TT4 A;  1C8T A;  1XFY A;  2X3B A;  1XFX A;  4AIG A;  2DW0 A;  3NX7 A;  1PWP A;  3USN A;  4GR3 A;  2OXU A;  5D1T A;  2JT6 A;  3LUN A;  3KME A;  3ELM A;  1KUK A;  4GQL A;  4R3V A;  3B8Z A;  3F19 A;  3N2U A;  1EUB A;  456C A;  1YQY A;  1KUH A;  1BQO A;  1WNI A;  1O0T A;  2OY2 A;  4FVL A;  4WK7 A;  1FBL A;  2OW1 A;  1IAC A;  1MMP A;  2KRJ A;  1ZVX A;  2TCL A;  1FM1 A;  2W14 A;  4H1Q A;  1BM6 A;  1IAE A;  4AXQ A;  1GXD A;  4GR0 A;  1XUR A;  1AST A;  1BZS A;  3DL1 A;  1HFS A;  5I3M A;  1Q3A A;  1K7Q A;  1USN A;  2XS3 A;  3WV3 A;  1A86 A;  1CGE A;  1L6J A;  1BUV M;  2D1N A;  2WOA A;  4H84 A;  5D7W A;  2MZI A;  2E2D A;  3AIG A;  1XFZ A;  3K7N A;  4ILW D;  2MZH A;  3LJT A;  3DTE A;  2N8R A;  3LIR A;  1EAK A;  1CAQ A;  2MZE A;  3F1A A;  3B2Z A;  2OVZ A;  4H3X A;  3KHI A;  4H49 A;  5D2B A;  4L6T A;  1PWQ A;  3LMC A;  4PKV A;  3DPE A;  1KUG A;  2HU6 A;  4HMA A;  4ON1 A;  1PWW A;  2X3A A;  5B5P A;  1BKC A;  1B3D A;  1XFU A;  4Q1L A;  1MMR A;  3KEK A;  1BKC I;  1ATL A;  3Q2H A;  2ERP A;  1R1I A;  4A7B A;  1CK7 A;  1OMJ A;  4FXQ A;  1CQR A;  3ZUK A;  3EDI A;  2QPJ A;  5BPA A;  4HX3 A;  1HV5 A;  1GE6 A;  1GE5 A;  5D1U A;  1R55 A;  1O0Q A;  1GKC A;  1UMT A;  1BIW A;  3EHY A;  1I76 A;  5CUH A;  1XFW A;  2L0R A;  4G0D A;  2ERQ A;  1KUF A;  1KAP P;  1D8M A;  2RJQ A;  1QIA A;  2POJ A;  1KUI A;  3KRY A;  3WV2 A;  4JQG A;  1RM8 A;  3ZVS A;  3RTT A;  1EB6 A;  1K7G A;  1Y0V A;  4PKW A;  1OM6 A;  3LJG A;  1JAO A;  1JAP A;  2CKI A;  1BKC E;  2SRT A;  2J83 A;  3U1R A;  2YIG A;  4H2E A;  3AYU A;  1AKL A;  1Y8J A;  2J0T A;  4L7A A;  4GR8 A;  5L7F A;  1OM7 A;  3EWJ A;  3HDB A;  3LGP A;  2JSD A;  1CGF A;  5I12 A;  1MMB A;  1SLN A;  1IAG A;  5L79 A;  4AYK A;  4PKU A;  1MNC A;  3UVC A;  5JMY A;  3P24 A;  5LAB A;  5CZM A;  5D1S A;  1SRP A;  1SAT A;  1S4B P;  1ROS A;  3GBO A;  4I03 A;  4IN9 A;  3HBU P;  2FV5 A;  1FLS A;  1ZS0 A;  4IUW A;  1CGL A;  2Z2D A;  3KWV C;  3VTG A;  2YB9 A;  1G9K A;  2K2G A;  1GO7 P;  1HTD A;  1OO9 A;  5BOT A;  1XUC A;  1BSW A;  2OW9 A;  4EFS A;  2Y6C A;  1K7I A;  1SLM A;  3WV1 A;  1IAD A;  4PKR A;  966C A;  2A8H A;  4DF9 A;  4PKT A;  4JPA A;  2MLS A;  4DD8 A;  1Y93 A;  3HDA P;  4WZV A;  2OI0 A;  3G42 A;  5I43 A;  4QKZ A;  4XCT A;  2CLT A;  1G49 A;  2DW2 A;  2XS4 A;  1UMS A;  1HOV A;  1C3I A;  1SU3 A;  3OHL A;  4GF1 A;  1A85 A;  2AYK A;  4J4M A;  4G9L A;  2FV9 A;  3VI1 A;  1DTH A;  2DDF A;  4GUY A;  1D7X A;  4PKQ A;  1OS2 A;  1JK3 A;  1QUA A;  5I2Z A;  2DW1 A;  2X7M A;  1CXV A;  1ZTQ A;  3L0V A;  2AIG P;  1D5J A;  1HFC A;  1JIZ A;  3E8R A;  2X3C A;  2O3E A;  1I1I P;  1I73 A;  3LUM A;  3LQ0 A;  2Y6D A;  3I7I A;  3EDH A;  3I7G A;  3O64 A;  2O36 A;  4H30 A;  3HB2 P;  1ZXV A;  1JIW P;  3K7L A;  2OXW A;  3EDZ A;  2OW0 A;  4GWN A;  4I35 A;  3CKI A;  3KEC A;  3L0T A;  1PWU A;  3RTS A;  4FXY P;  4WKE A;  5I0L A;  2JNP A;  3DTI A;  3LKA A;  1OM8 A;  1QIC A;  2E3X A;  4CTH A;  3OHO A;  4IJO A;  1KBC A;  5I4O A;  3HBV P;  2YUF A;  3TVC A;  3B92 A;  3DSL A;  2K9C A;  1DMT A;  2MLR A;  4DV8 A;  2OZR A;  1JJ9 A;  1G12 A;  1ZP5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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